Haemopoietic stem cell ontogeny

Lead Research Organisation: University of Oxford

Abstract

Stem cells hold out the prospect of tissue repair strategies throughout the human body. The archetypal adult stem cell is the blood, or haemopoietic, stem cell (HSC), which resides in the bone marrow and furnishes the body with all its blood cell types throughout adult life. We already know more about this stem cell than any other and it will continue to drive our understanding of stem cell biology. In addition, a better knowledge of the molecular programming of the HSC will aid our understanding of blood diseases, including leukaemias, and their therapies.||Cells are programmed during embryonic development by signals received from surrounding cells. These signals determine the profile of gene expression characteristic of that cell. We have therefore chosen to focus our study of HSC molecular programming on the embryonic signals and the proteins in the nucleus that respond to these signals and control gene expression, the so-called transcription factors (TFs). In order to determine the signalling regime, one needs to know where the cells originate in the embryo and where they move to during embryogenesis. These issues are very difficult to study in mammalian embryos which develop in the womb. We are therefore using amphibian and fish embryos which develop externally and in large numbers. By stimulation or inhibition of individual signals or TFs, we can gradually build up the genetic programme that controls the formation and subsequent behaviour of HSCs. Many studies indicate that the pathways we identify in this way will be conserved in mammals including humans. In these ways we will be able to better understand what has gone wrong in blood diseases and the consequences of drug therapies. We expect that our studies will influence attempts to make HSCs for study and therapy in the laboratory from human embryonic stem cells.||Blood develops in close association with blood vessels. Recently, we have begun to uncover an evolutionary link with the heart, whereby a population of blood and endothelial precursors in the zebrafish appear to have been recruited into the mammalian heart, explaining the evolution of the four-chambered from the two-chambered heart. Our studies of the developmental programmes of these different tissue types have allowed us to identify candidate genetic switches for this recruitment. Importantly, the more recently recruited cells may retain an evolutionary memory of the endothelial cell programme, making them attractive candidates for multi-potential stem cells in the adult, with obvious significance for the repair of the adult heart.

Technical Summary

Stem cells hold out the prospect of tissue repair strategies throughout the human body. The archetypal adult stem cell is the haemopoietic stem cell (HSC), which resides in the bone marrow and furnishes the body with all its blood cell types throughout adult life. We already know more about this stem cell than any other and it will continue to drive our understanding of stem cell biology. In addition, a better knowledge of the molecular programming of the HSC will aid our understanding of blood diseases, including leukaemias, and their therapies. Cells are programmed during embryonic development by signals received from surrounding cells. These signals determine the combination of transcription factors (TFs) active in the nucleus and thereby the profile of gene expression characteristic of that cell. We have therefore chosen to focus our study of HSC molecular programming on the embryonic signals and nuclear TFs. In order to determine the signalling regime, one needs to know where the cells originate in the embryo and where they move to during embryogenesis. These issues are very difficult to study in mammalian embryos which develop in the womb. We are therefore using amphibian and fish embryos which develop externally and in large numbers. It is also now straight forward to determine gene function by engineering their gain or their loss in developing embryos. High throughput methods for determining gene expression enable the molecular consequences of gain and loss of function to be elucidated in great detail. Many studies indicate that the pathways identified here are conserved in mammals including humans. Using combinations of genetic mutations in, and small molecule inhibitors of, embryonic signalling pathways, we are building a picture of the cascade of signals required to programme an HSC. We are recapitulating the conditions in vitro with a view to making HSCs in the lab. These studies will influence the programming of HSCs from human embryonic stem cells (hESCs), an achievement that could enable the tolerising of patients to transplantation of other tissues derived from the same hESC line. We are also working out which TFs are activated by which signal, and how each activation affects the expression of other TFs important in the programming of HSCs. The genetic regulatory networks we are building will help us to understand the consequences of perturbations to specific TFs in blood diseases and how they react to drug therapies. Blood develops in close association with blood vessels. Recently, we have begun to uncover an evolutionary link with the heart, whereby a population of blood and endothelial precursors in the zebrafish appear to have been recruited into the mammalian heart, explaining the evolution of the four-chambered from the two-chambered heart. Our studies of the developmental programmes of these different tissue types have allowed us to identify candidate genetic switches for this recruitment. Importantly, the more recently recruited cells may retain an evolutionary memory of the endothelial cell programme, making them attractive candidates for multi-potential stem cells in the adult, with obvious significance for the repair of the adult heart.

Publications

10 25 50
 
Description BHF Project grant
Amount £176,000 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2006 
End 03/2009
 
Description CardioCell
Amount £250,000 (GBP)
Funding ID 223372 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 04/2010 
End 10/2012
 
Description DTI Collaborative
Amount £85,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 03/2007 
End 06/2008
 
Description EuTRACC
Amount £200,000 (GBP)
Funding ID 37445 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 04/2007 
End 03/2011
 
Description EuroCSCs
Amount £140,000 (GBP)
Funding ID 37632 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2007 
End 03/2010
 
Description Eurythron
Amount £200,000 (GBP)
Funding ID 5499 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 08/2004 
End 10/2008
 
Description Leukaemia Research Fund Programme Grant
Amount £320,000 (GBP)
Organisation Leukaemia and Lymphoma Research 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2006 
End 03/2010
 
Description Wellcome Trust DPhil Programme
Amount £140,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2010 
End 09/2013
 
Description BMP/GATA/Sox 
Organisation University of Nottingham
Department School of Biology Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Advice, criticism and paper writing
Collaborator Contribution Experiments
Impact 17183467 and 18572157
 
Description CardioCell 
Organisation European Molecular Biology Laboratory
Country Germany 
Sector Public 
PI Contribution Intellectual and experimental
Collaborator Contribution Intellectual and experimental
Impact 21750034, 21212394. Multi-disciplinary with cardiology, pharmacology, developmental biology, stem cell biology and mouse genetics.
Start Year 2009
 
Description CardioCell 
Organisation Imperial College London
Department National Heart & Lung Institute (NHLI)
Country United Kingdom 
Sector Academic/University 
PI Contribution Intellectual and experimental
Collaborator Contribution Intellectual and experimental
Impact 21750034, 21212394. Multi-disciplinary with cardiology, pharmacology, developmental biology, stem cell biology and mouse genetics.
Start Year 2009
 
Description CardioCell 
Organisation Lund University
Department Lund Stem Cell Centre
Country Sweden 
Sector Academic/University 
PI Contribution Intellectual and experimental
Collaborator Contribution Intellectual and experimental
Impact 21750034, 21212394. Multi-disciplinary with cardiology, pharmacology, developmental biology, stem cell biology and mouse genetics.
Start Year 2009
 
Description CardioCell 
Organisation Pasteur Institute, Paris
Department Department of Developmental Genetics
Country France 
Sector Private 
PI Contribution Intellectual and experimental
Collaborator Contribution Intellectual and experimental
Impact 21750034, 21212394. Multi-disciplinary with cardiology, pharmacology, developmental biology, stem cell biology and mouse genetics.
Start Year 2009
 
Description CardioCell 
Organisation University of Cologne
Country Germany 
Sector Academic/University 
PI Contribution Intellectual and experimental
Collaborator Contribution Intellectual and experimental
Impact 21750034, 21212394. Multi-disciplinary with cardiology, pharmacology, developmental biology, stem cell biology and mouse genetics.
Start Year 2009
 
Description CardioCell 
Organisation University of Oxford
Department Weatherall Institute of Molecular Medicine (WIMM)
Country United Kingdom 
Sector Public 
PI Contribution Intellectual and experimental
Collaborator Contribution Intellectual and experimental
Impact 21750034, 21212394. Multi-disciplinary with cardiology, pharmacology, developmental biology, stem cell biology and mouse genetics.
Start Year 2009
 
Description Eto2 
Organisation University of Oxford
Department Weatherall Institute of Molecular Medicine (WIMM)
Country United Kingdom 
Sector Public 
PI Contribution Intellectual and practical
Collaborator Contribution Intellectual and practical
Impact Paper accepted.
Start Year 2009
 
Description EuTRACC 
Organisation Advanced Biotechnology Centre
Country United Arab Emirates 
Sector Private 
PI Contribution Experimental and intellectual.
Collaborator Contribution Intellectual and experimental
Impact 17108004, 22801375. Multi-disciplinary covering cell and molecular biology, mouse genetics, stem cell biology, developmental biology, haematopoiesis, neurogenesis, proteomics and bioinformatics
Start Year 2007
 
Description EuTRACC 
Organisation Babraham Institute
Department Stem Cell Sciences UK Ltd
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Experimental and intellectual.
Collaborator Contribution Intellectual and experimental
Impact 17108004, 22801375. Multi-disciplinary covering cell and molecular biology, mouse genetics, stem cell biology, developmental biology, haematopoiesis, neurogenesis, proteomics and bioinformatics
Start Year 2007
 
Description EuTRACC 
Organisation Biology and Molecular Genetics
Country Italy 
Sector Academic/University 
PI Contribution Experimental and intellectual.
Collaborator Contribution Intellectual and experimental
Impact 17108004, 22801375. Multi-disciplinary covering cell and molecular biology, mouse genetics, stem cell biology, developmental biology, haematopoiesis, neurogenesis, proteomics and bioinformatics
Start Year 2007
 
Description EuTRACC 
Organisation Erasmus University Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution Experimental and intellectual.
Collaborator Contribution Intellectual and experimental
Impact 17108004, 22801375. Multi-disciplinary covering cell and molecular biology, mouse genetics, stem cell biology, developmental biology, haematopoiesis, neurogenesis, proteomics and bioinformatics
Start Year 2007
 
Description EuTRACC 
Organisation Helmholtz Association of German Research Centres
Department Helmholtz Zentrum Munchen
Country Germany 
Sector Public 
PI Contribution Experimental and intellectual.
Collaborator Contribution Intellectual and experimental
Impact 17108004, 22801375. Multi-disciplinary covering cell and molecular biology, mouse genetics, stem cell biology, developmental biology, haematopoiesis, neurogenesis, proteomics and bioinformatics
Start Year 2007
 
Description EuTRACC 
Organisation Karlsruhe Institute of Technology
Country Germany 
Sector Academic/University 
PI Contribution Experimental and intellectual.
Collaborator Contribution Intellectual and experimental
Impact 17108004, 22801375. Multi-disciplinary covering cell and molecular biology, mouse genetics, stem cell biology, developmental biology, haematopoiesis, neurogenesis, proteomics and bioinformatics
Start Year 2007
 
Description EuTRACC 
Organisation Max Planck Society
Department Max Planck Institute for Molecular Cell Biology and Genetics
Country Germany 
Sector Public 
PI Contribution Experimental and intellectual.
Collaborator Contribution Intellectual and experimental
Impact 17108004, 22801375. Multi-disciplinary covering cell and molecular biology, mouse genetics, stem cell biology, developmental biology, haematopoiesis, neurogenesis, proteomics and bioinformatics
Start Year 2007
 
Description EuTRACC 
Organisation Ottawa Hospital Research Institute
Department International Regulome Consortium (IRC)
Country Canada 
Sector Academic/University 
PI Contribution Experimental and intellectual.
Collaborator Contribution Intellectual and experimental
Impact 17108004, 22801375. Multi-disciplinary covering cell and molecular biology, mouse genetics, stem cell biology, developmental biology, haematopoiesis, neurogenesis, proteomics and bioinformatics
Start Year 2007
 
Description EuTRACC 
Organisation Research Institute of Molecular Pathology (IMP)
Country Austria 
Sector Academic/University 
PI Contribution Experimental and intellectual.
Collaborator Contribution Intellectual and experimental
Impact 17108004, 22801375. Multi-disciplinary covering cell and molecular biology, mouse genetics, stem cell biology, developmental biology, haematopoiesis, neurogenesis, proteomics and bioinformatics
Start Year 2007
 
Description EuTRACC 
Organisation Technical University of Dresden
Country Germany 
Sector Academic/University 
PI Contribution Experimental and intellectual.
Collaborator Contribution Intellectual and experimental
Impact 17108004, 22801375. Multi-disciplinary covering cell and molecular biology, mouse genetics, stem cell biology, developmental biology, haematopoiesis, neurogenesis, proteomics and bioinformatics
Start Year 2007
 
Description EuTRACC 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Experimental and intellectual.
Collaborator Contribution Intellectual and experimental
Impact 17108004, 22801375. Multi-disciplinary covering cell and molecular biology, mouse genetics, stem cell biology, developmental biology, haematopoiesis, neurogenesis, proteomics and bioinformatics
Start Year 2007
 
Description EuTRACC 
Organisation University Medical Center Utrecht (UMC)
Country Netherlands 
Sector Academic/University 
PI Contribution Experimental and intellectual.
Collaborator Contribution Intellectual and experimental
Impact 17108004, 22801375. Multi-disciplinary covering cell and molecular biology, mouse genetics, stem cell biology, developmental biology, haematopoiesis, neurogenesis, proteomics and bioinformatics
Start Year 2007
 
Description EuTRACC 
Organisation University of Basel
Country Switzerland 
Sector Academic/University 
PI Contribution Experimental and intellectual.
Collaborator Contribution Intellectual and experimental
Impact 17108004, 22801375. Multi-disciplinary covering cell and molecular biology, mouse genetics, stem cell biology, developmental biology, haematopoiesis, neurogenesis, proteomics and bioinformatics
Start Year 2007
 
Description EuTRACC 
Organisation University of Bergen
Country Norway 
Sector Academic/University 
PI Contribution Experimental and intellectual.
Collaborator Contribution Intellectual and experimental
Impact 17108004, 22801375. Multi-disciplinary covering cell and molecular biology, mouse genetics, stem cell biology, developmental biology, haematopoiesis, neurogenesis, proteomics and bioinformatics
Start Year 2007
 
Description EuTRACC 
Organisation University of Cambridge
Department Gurdon Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Experimental and intellectual.
Collaborator Contribution Intellectual and experimental
Impact 17108004, 22801375. Multi-disciplinary covering cell and molecular biology, mouse genetics, stem cell biology, developmental biology, haematopoiesis, neurogenesis, proteomics and bioinformatics
Start Year 2007
 
Description EuTRACC 
Organisation University of Leeds
Department Leeds Institute of Molecular Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Experimental and intellectual.
Collaborator Contribution Intellectual and experimental
Impact 17108004, 22801375. Multi-disciplinary covering cell and molecular biology, mouse genetics, stem cell biology, developmental biology, haematopoiesis, neurogenesis, proteomics and bioinformatics
Start Year 2007
 
Description EuroCSCs 
Organisation Cancer Research UK
Department Cancer Research UK London Research Institute (LRI)
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Intellectual and experimental
Collaborator Contribution Intellectual and experimental
Impact 20412772. Multi-disciplinary including cell and molecular biology, stem cell biology, developmental biology, mouse genetics, haematopoiesis and leukaemogenesis
Start Year 2006
 
Description EuroCSCs 
Organisation European Molecular Biology Laboratory
Country Germany 
Sector Public 
PI Contribution Intellectual and experimental
Collaborator Contribution Intellectual and experimental
Impact 20412772. Multi-disciplinary including cell and molecular biology, stem cell biology, developmental biology, mouse genetics, haematopoiesis and leukaemogenesis
Start Year 2006
 
Description EuroCSCs 
Organisation Lund University
Department Lund Stem Cell Centre
Country Sweden 
Sector Academic/University 
PI Contribution Intellectual and experimental
Collaborator Contribution Intellectual and experimental
Impact 20412772. Multi-disciplinary including cell and molecular biology, stem cell biology, developmental biology, mouse genetics, haematopoiesis and leukaemogenesis
Start Year 2006
 
Description EuroCSCs 
Organisation University of Copenhagen
Country Denmark 
Sector Academic/University 
PI Contribution Intellectual and experimental
Collaborator Contribution Intellectual and experimental
Impact 20412772. Multi-disciplinary including cell and molecular biology, stem cell biology, developmental biology, mouse genetics, haematopoiesis and leukaemogenesis
Start Year 2006
 
Description GATA/Wnt 
Organisation University of Aberdeen
Department Institute of Medical Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Intellectual and experimental
Collaborator Contribution Intellectually and experimentally
Impact 18715946
 
Description HSCs from ESCs 
Organisation University of Oxford
Department Weatherall Institute of Molecular Medicine (WIMM)
Country United Kingdom 
Sector Public 
PI Contribution Intellectual and experimental.
Collaborator Contribution Intellectual and experimental.
Impact None yet.
Start Year 2014
 
Description Sensory neurons 
Organisation University of Oxford
Department Department of Physiology, Anatomy and Genetics
Country United Kingdom 
Sector Academic/University 
PI Contribution Experimental and intellectual
Collaborator Contribution Intellectual
Impact 21061240
Start Year 2008
 
Description Small molecules 
Organisation University of Oxford
Department Department of Chemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution Intellectual and experimental
Collaborator Contribution Intellectual and experimental
Impact 19531361
Start Year 2007
 
Description Structure 
Organisation University of Oxford
Department Wellcome Trust Centre for Human Genetics
Country United Kingdom 
Sector Academic/University 
PI Contribution Intellectual and experimental
Collaborator Contribution Intellectual and experimental
Impact 21076045 Structure function analysis
Start Year 2010
 
Description Tel-Aml leukaemia 
Organisation Medical Research Council (MRC)
Department MRC Molecular Haematology Unit
Country United Kingdom 
Sector Public 
PI Contribution Intellectual and experimental
Collaborator Contribution Intellectually and experimentally
Impact 17442775 and 20412772
 
Description Tel-TRKC leukaemia 
Organisation University College London
Department UCL Cancer Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Experimental and intellectual
Collaborator Contribution Intellectual and experimental
Impact None so far
Start Year 2010
 
Description VEGF signalling from the somites. 
Organisation University of Oxford
Department Weatherall Institute of Molecular Medicine (WIMM)
Country United Kingdom 
Sector Public 
PI Contribution Intellectual and experimental.
Collaborator Contribution Intellectual and experimental.
Impact None yet.
Start Year 2014
 
Description FameLab UK regional final 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact To create awareness. Rapping (Singing) about the process of haematopoiesis for the FameLab science communication competition, rewarded with the second prize.
Year(s) Of Engagement Activity 2017
 
Description 3 minute thesis competition 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Participate in the Unieristy of Oxford Three minute Thesis Competition which is part of a worldwide initiative which encourages Ph.D studewnts to present a topic/their research in three minutes. Received an award and certificate and receivedcontradionts via email and social networks.
Year(s) Of Engagement Activity 2016
 
Description Biomedical Services visit, Oxford 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Presentation of the importance and wider context of research about understanding the molecular regulators of blood stem cells for therapeutic use and discussions on topics related to stem cell based anti cancer therapies. Audience engaged in the presentation as proven by following discussions and positive feedback. Presentation also started an initiative in the building to encourage people to register as bone marrow donors.
Year(s) Of Engagement Activity 2016
 
Description Cheltenham Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Stimulated interest

This was considered successful and the WIMM will repeat this events.
Year(s) Of Engagement Activity 2013
 
Description Dutch students 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact 50 students visited and asked questions

High interest
Year(s) Of Engagement Activity 2011
 
Description Hands-on activities, including virtual reality tour of DNA - Royal Society Summer Science Exhibition, Royal Society, London 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Huge amount of positive feedback at the time from visitors, engagement with social media posts, collaborative working across department and WIMM
Year(s) Of Engagement Activity 2017
 
Description Hands-on activities, including virtual reality tour of DNA - Royal Society Summer Science Exhibition, Royal Society, London 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Huge amount of positive feedback at the time from visitors, engagement with social media posts, collaborative working across department and WIMM
Year(s) Of Engagement Activity 2017
 
Description MRC Festival for Medical Research Oxford (Science in the Slupermarket Roadshow) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Describing to the general public how the immune system flights cancer using three activities representing research currently ongoing. General awareness to the general public.
Year(s) Of Engagement Activity 2016
 
Description MRC Public Engagement 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Engaging the public in the science that is carried out in the Institute and stimulating interest in a scientific career.

This was very successful and will be repeated next year.
Year(s) Of Engagement Activity 2013
 
Description Oxford Hands-On-Science 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Help with main events of the year, the Science Roadshow, visiting schools to do a series of demonstrations covering a wide spectrum of sciences to encourage pupils to participate in the activities and ask questions and discuss the related topics.
Year(s) Of Engagement Activity 2016
 
Description Oxford Parkways Year 10 Taster Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Media (as a channel to the public)
Results and Impact Oxford Parkways Year 10 Taster Day. Delivering a presentation and interactive workshop on Mendelian genetics and extensive discussion on topics related to stem cells, molecular genetics and the future of regenerative medicine. Students understood the concepts very well which was reflected by their participation in the discussions and were very keen to ask stimulating questions relating to this area of research.
Year(s) Of Engagement Activity 2016
 
Description Poetry of Science (part of Oxfordshire Science Festival) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Undergraduate students
Results and Impact Helping with the organisation of a Science Poetry competition for the pupils of local schools, judging the winning pieces and presenting my science raps during the final event
Year(s) Of Engagement Activity 2017
 
Description PubHD event, which is part of the UK- and Europe-wide initiative 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact The audience was very engaged in my topic, as evidenced by the questions that I received. The organisers thanked me for my participation via Twitter and Facebook. I have heard from other PhD students that this event inspired them to give it a try themselves.
Year(s) Of Engagement Activity 2017
URL https://pubhd.wordpress.com/
 
Description Science Festival, Oxford 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Part of Worldwide Pint of Science Festival to organise speakers to come and give talks to the general public in Oxford where people enjoyed this type of science outreach
Year(s) Of Engagement Activity 2016
 
Description Stanton St John WI 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact 25 WI members attended the talk and asked a lot of questions.

A lot of very positive feedback
Year(s) Of Engagement Activity 2011
 
Description Super Science Event at the Natural History Museum 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Wrote a blog post for the WIMM blog about participation in a Super Science Saturday event at the Natural History Museum
Year(s) Of Engagement Activity 2017
 
Description Super Science Saturdays, The Museum of Natural History, Oxford 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Research created activites to describe to families and school-age children about scientific concepts and principles that they are working on, which received lots of enthusiasm.
Year(s) Of Engagement Activity 2016
 
Description Talk about the work of a researcher/scientist to preschool children. Talk about the blood using aqua crystals and cuddly toys 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact To start an understanding
Year(s) Of Engagement Activity 2017
 
Description Youth Centre (Latvia) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited to give two presentations in Chemistry and Biology, involving basic experiments. The activity was a chance for the group to experience something they do not learn hands-on- at schools and also practise their English skills. Received official thank you from the Youth Centre. Approached by people from the group with questions regarding studying in the UK and learning English.
Year(s) Of Engagement Activity 2016