Neurobehavioural genetics. Isolation and characterisation of behavioural mutations in mice

Lead Research Organisation: MRC Mammalian Genetics Unit

Abstract

Twin and adoption studies have consistently implicated genetics in the aetiology of psychiatric and behavioural disorders. The identification of the genes and molecular pathways that are associated with these traits using linkage studies has been difficult because psychiatric disorders are almost always non-mendelian, heterogeneous, involve multiple genetic loci and are influenced significantly by environmental factors. Mouse models that are based on intermediate signatures of psychiatric disease and pharmacological responsiveness hold promise as a complementary approach to dissecting the molecular basis of neurobehavioural disorders. This has been made possible by the development and refinement of gene targeting technologies and the use of super-efficient chemical mutagens. ENU mutagenesis in the mouse, when coupled to a battery of sensitive behavioural screens is an effective way of creating and identifying novel mouse behavioural mutants. Screens for specific deficits in behaviours such as biological rhythms and learning/memory are being used in combination with molecular genetic techniques to identify and characterise genes with a behavioural function.||It is hoped that the study of mouse mutants that have arisen from these screens will provide new insights into the genetic basis of abnormal behaviour and that they might lead to the development of novel therapeutic compounds for human psychiatric disease.

Technical Summary

Genetic approaches provide a powerful means by which to examine the biological basis of nervous system diseases such as dementias, neurodegenerative disorders and affective disorders as well as the physiological processes that are affected by them. Almost all mental illnesses are accompanied by abnormal physiological and neurological characteristics that can be readily observed in mice. Phenotype-based approaches have been used successfully in organisms such as Drosophila melanogaster in establishing a genetic basis for many behavioural processes. Use of the chemical mutagen ENU along with hierarchical screening protocols has indicated that phenotype-based approaches in the mouse will be useful in gaining a molecular insight into complex mammalian behaviours.||One of the goals of this group is to identify and characterise ENU-induced mutations that affect specific behavioural processes. The first class of mutations being screened for are those which affect the mammalian circadian clock. The circadian system can be divided into three basic components - the input or entrainment pathway, the central pacemaker and the output pathway. Disruption of any of these components could be responsible for rhythm and sleep anomalies associated with complex psychiatric disorders. Pacemaker function is generally assessed by measuring an identifiable component of the output pathway such as locomotor (wheel-running) activity. The second class of mutations being screened for are those that affect learning and memory. Using these screens, we can identify not only molecular components specifically associated with memory formation but also components associated with neural mechanisms such as migration, plasticity and degeneration.||Paradigms such as Spontaneous Alternation, Novel Object Recognition, Holeboard exploration and Attention testing screens are being used to identify potential mutants. Positional cloning of several mutations identified in these screens is currently underway. This approach is complemented by carrying out molecular analysis of novel mutations. Primarily this involves histological analysis and in situ hybridization of brain regions suspected to be associated with particular behaviours. For example, circadian rhythms are associated with a brain region called the suprachiasmatic nucleus, located in the hypothalamus and consisting of approximately 10,000 cells. Histological analysis tells us whether there is a gross dysmorphology associated with the mutation, indicating that underlying neurodevelopmental processes might be affected.||In addition, by using specific molecular markers known to be associated with a particular behaviour, we can determine the molecular consequences of each mutation. Systematic approaches to characterising molecular pathways associated with behavioural traits are being established.

Publications

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Anand SN (2012) Generation of mouse mutants as tools in dissecting the molecular clock. in Progress in brain research

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Banks G (2016) Reciprocal interactions between circadian clocks and aging. in Mammalian genome : official journal of the International Mammalian Genome Society

 
Description Guiding Principles for Behavioural Laboratory Animal Science
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description BBSRC Project Grant
Amount £655,578 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2012 
End 04/2015
 
Description EU COllaborative Project
Amount £723,000 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 04/2009 
End 03/2012
 
Description EU FP6 Integrated Project
Amount £150,000 (GBP)
Organisation Sixth Framework Programme (FP6) 
Sector Public
Country European Union (EU)
Start 01/2006 
End 01/2011
 
Description NARSAD Young Investigator Grant
Amount $60,000 (USD)
Organisation Brain & Behaviour Research Foundation 
Sector Charity/Non Profit
Country United States
Start 01/2013 
End 01/2015
 
Title Mouse Mutant Models 
Description Generation of mouse models of human neurological and psychiatric disease 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2006 
Provided To Others? Yes  
Impact High impact publications 
 
Description Analysis of light entrainment and sleep in mice 
Organisation University of Oxford
Department Nuffield Laboratory of Ophthalmology Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution genetic and behavioural analysis of mouse mutants
Collaborator Contribution Expertise in molecular and cellular analysis of mouse mutant phenotypes
Impact High impact publications in Cell, Nature Communications, NAR, Neurobiology Aging, PLoS Biology etc
Start Year 2010
 
Description Behavioural phenotyping, motor function cognition and sleep 
Organisation Italian Institute of Technology (Istituto Italiano di Tecnologia IIT)
Department Neuroscience and Brain Technologies IIT
Country Italy 
Sector Academic/University 
PI Contribution Publications Development of new phenotyping technologies
Collaborator Contribution Equal contributions in management, design and experimental work
Impact High impact publications in Molecular Psychiatry, Cell Reports, J Clin Invest, Dis Model Mech etc.
Start Year 2006
 
Description Behavioural phenotyping, motor function cognition and sleep 
Organisation National Research Council
Department Institute of Neuroscience (CNR-IN)
Country Italy 
Sector Public 
PI Contribution Publications Development of new phenotyping technologies
Collaborator Contribution Equal contributions in management, design and experimental work
Impact High impact publications in Molecular Psychiatry, Cell Reports, J Clin Invest, Dis Model Mech etc.
Start Year 2006
 
Description Beta Catenin mutations in humans and mice 
Organisation Radboud University Nijmegen
Country Netherlands 
Sector Academic/University 
PI Contribution Behavioural, molecular and cellular characterization of a mouse line carrying a mutation in beta catenin.
Collaborator Contribution Identification and description of numerous ID patients carrying de novo mutations in beta catenin
Impact High impact publication, Journal of Clinical Investigation
Start Year 2013
 
Description Beta catenin protein structural variant 
Organisation University of Reading
Country United Kingdom 
Sector Academic/University 
PI Contribution Mouse with mis-sense mutation in beta catenin
Collaborator Contribution Experience in analysis of 3D-protein structure aided in assigning a mechanism for beta catenin dysfunction in the mouse mutant.
Impact High impact publication, Journal of Clinical Investigation
Start Year 2013
 
Description Biophysical investigation of synaptic vesicle fusion in mouse mutants 
Organisation University College London
Department Institute of Neurology
Country United Kingdom 
Sector Academic/University 
PI Contribution Mouse carrying a mutation in Vamp2
Collaborator Contribution Biophysical investigation into the effects of the Vamp2 mutation Electrophysiological investigation into the effects of the Vamp2 mutation
Impact Data for scientific publication
Start Year 2014
 
Description Biophysical investigation of synaptic vesicle fusion in mouse mutants 
Organisation Yale University
Country United States 
Sector Academic/University 
PI Contribution Mouse carrying a mutation in Vamp2
Collaborator Contribution Biophysical investigation into the effects of the Vamp2 mutation Electrophysiological investigation into the effects of the Vamp2 mutation
Impact Data for scientific publication
Start Year 2014
 
Description Cacna1c Calcium channel kinetics 
Organisation Brown University
Country United States 
Sector Academic/University 
PI Contribution We have characterised two mutant alleles of Cacna1c, both with behavioural deficits. We have provided mammalian expression vectors to study Ca channel kinetics in cells.
Collaborator Contribution Collaborators have overexpressed mutant forms of Cacna1c in cells and have investigated changes in Calcium channel kinetics. The mechanisms identified can be used to explain the behavioural phenotypes seen in the mutant mouse lines.
Impact High impact publication currently being drafted.
Start Year 2018
 
Description Ciliary dysfunction in Katnal1 mutant mice 
Organisation University of Leicester
Country United Kingdom 
Sector Academic/University 
PI Contribution Our investigations of behaviour in Katnal1 mice directed us towards investigating ciliary dysfunction in ependymal cells. We provided the tissues for this collaboration.
Collaborator Contribution Our partners analysed structure and dynamics of cilia in ependymal cells.
Impact High impact publication, Molecular Psychiatry
Start Year 2016
 
Description Cortical anomalies in Katnal1 mice 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Katnal1 mutant mouse
Collaborator Contribution Immunofluorescence analysis of cortical layers in mutant mice
Impact High impact publication, Molecular Psychiatry
Start Year 2016
 
Description Home-cage phenotyping 
Organisation Actual Analytics
Country United Kingdom 
Sector Private 
PI Contribution A new home-cage video monitoring system is being developed by Actual Analytics. Our group and others at Harwell are involved with annotating behaviours of group-house mice for the purposes of automated tracking of these behaviours
Collaborator Contribution Partners are developing the technology
Impact Prototypes of behavioural phenotyping modules for home-cage assessment of behaviour.
Start Year 2014
 
Description Identification and characterisation of human genes underlying sleep and circadian disorders 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution Exome sequencing to be analysed by our group and the Bioinformatics team at Harwell. Downstream analysis (including the development of CRISPR mouse models) to be overseen or performed by the neurobehavoural genetics team at Harwell.
Collaborator Contribution Patient diagnosis and DNA extraction to be performed by Newcastle University colleagues.
Impact Human genetics, Bioinformatics, Neuroscience. Study has just commenced, outcomes to be updated.
Start Year 2018
 
Description Identification of novel neurological mutants 
Organisation Medical Research Council (MRC)
Department MRC Functional Genomics Unit
Country United Kingdom 
Sector Public 
PI Contribution Identification of abnormal mouse phenotypes using neurological screens, inheritance testing, mapping and cloning
Collaborator Contribution Molecular and cellular analysis of mutantsMolecular and cellular analysis of mouse mutants
Impact High impact publications
 
Description Identification of novel neurological mutants 
Organisation University College London
Department Institute of Neurology
Country United Kingdom 
Sector Academic/University 
PI Contribution Identification of abnormal mouse phenotypes using neurological screens, inheritance testing, mapping and cloning
Collaborator Contribution Molecular and cellular analysis of mutantsMolecular and cellular analysis of mouse mutants
Impact High impact publications
 
Description Period2 protein structural variant 
Organisation University of California, Santa Cruz (UCSC)
Country United States 
Sector Academic/University 
PI Contribution We identified a Per2 mis-sense variant, mouse expresses a circadian phenotype
Collaborator Contribution Our partner in this study provided the protein structural data supporting our molecular findings that mutant Per2 is more susceptible to proteasomal degradation.
Impact High impact publication Proc Natl Acad Sci.
Start Year 2015
 
Description Sleep paralysis genetic associations 
Organisation Goldsmiths, University of London
Country United Kingdom 
Sector Academic/University 
PI Contribution genotyping and genetic analysis
Collaborator Contribution Human cohort study
Impact Publication J Sleep Res
Start Year 2013
 
Description Slice and cell electrophysiology studies in mutants 
Organisation University of Exeter
Country United Kingdom 
Sector Academic/University 
PI Contribution We provide mutants where particular genes or behavioural processes are affected.
Collaborator Contribution Our partners provide the expertise and infrastructure for electrophysiology studies.
Impact Ongoing work will be used in future publications.
Start Year 2018
 
Description Social jetlag and metabolic dysfunctions in a large human cohort study 
Organisation Duke University
Country United States 
Sector Academic/University 
PI Contribution Analysed cohort data
Collaborator Contribution Collected cohort data and provided additional information
Impact Publication Int J Obesity
Start Year 2013
 
Description Social jetlag and metabolic dysfunctions in a large human cohort study 
Organisation Goldsmiths, University of London
Country United Kingdom 
Sector Academic/University 
PI Contribution Analysed cohort data
Collaborator Contribution Collected cohort data and provided additional information
Impact Publication Int J Obesity
Start Year 2013
 
Description Social jetlag and metabolic dysfunctions in a large human cohort study 
Organisation University of Otago
Country New Zealand 
Sector Academic/University 
PI Contribution Analysed cohort data
Collaborator Contribution Collected cohort data and provided additional information
Impact Publication Int J Obesity
Start Year 2013
 
Description Tauopathy modifiers 
Organisation Medical Research Council (MRC)
Department MRC Laboratory of Molecular Biology (LMB)
Country United Kingdom 
Sector Public 
PI Contribution Crossing Tauopathy model to ENU injected mice. Screening for enhancer or suppressor of phenotype, inheritance testing, mapping and cloning.
Collaborator Contribution Provision of mouse tauopathy model to identify ENU modifiers. Funding for Research assistant at Harwell and shared Postdoctoral Fellow based in Cambridge.
Impact In progress, new modifiers identified.
Start Year 2007
 
Description analysis of mouse circadian behaviour 
Organisation Medical Research Council (MRC)
Department MRC Laboratory of Molecular Biology (LMB)
Country United Kingdom 
Sector Public 
PI Contribution Identification,characterization and cloning of mutants
Collaborator Contribution Cellular analysis and imaging of mouse mutants
Impact High impact publications in Science, Cell, PNAS, Molecular Psychiatry etc.
 
Description Big Data Neurophysiology 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Discussion on how neurophysiology projects might be used with mouse high-throughput phenotyping projects
Year(s) Of Engagement Activity 2017
 
Description Brain twitter conference 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Postdoc Nora Bourbia was selected to present one of our work projects at the first Brain Twitter Conference. Presentation was in the form of a series of 6 tweets. Sparked comments and interaction from numerous individuals.
Year(s) Of Engagement Activity 2017
 
Description Cherwell School 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Sixth form talk on genetics of circadian rhythms/chronobiology. resulted in several conversations with interested students.

Students enquired about careers in science.
Year(s) Of Engagement Activity 2013
 
Description Clock club organisation 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Over 150 scientists attended symposium organised by my group. Promoted networking and interaction amongst circadian scientists at a National level.

Collaborative work.
Year(s) Of Engagement Activity 2014
URL http://www.genetics.org.uk/Conferences/tabid/84/Filter/64%20GSS/ClientID/1/MeetingNo/GTS_405/view/Co...
 
Description Clock club presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact National group working in the field of biological rhythms informed about our research updates

More interest from UK research community
Year(s) Of Engagement Activity 2012,2013,2014
 
Description Didcot Girls School career fair 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact We set up a Career workshop to share our choice in science, advice on career path, a typical day at our work and answer questions.
Year(s) Of Engagement Activity 2017
 
Description European researchers Night, Oxford 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact We had an exhibition of our work at the Ashmolean Museum, Oxford, attended by general public. Our postdocs were present and engaged with the general public, discussing the impact of our work on brain, circadian rhythms and sleep.
Year(s) Of Engagement Activity 2017
 
Description Festival of Ancient and Moden Science 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact We manned a stand at this festival explaining our work on biological clocks and sleep. Many interested parties came to the stand. In one case, we set up a visit to our labs by one of the students for a week of shadowing.
Year(s) Of Engagement Activity 2017
 
Description Genetics of Psychology lectures 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact Over 80 students attended these lectures on gene x environment interactions, there were several informal discussions with students afterwards.

Interest in our group's research shown by students.
Year(s) Of Engagement Activity 2012,2013,2014
 
Description Harwell Mouse Genetics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Presentation on mouse neurogenetics and neurophenotyping
Year(s) Of Engagement Activity 2018
 
Description I'm a scientist, get me out of here! 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact This is an online event sponsored by The Wellcome Trust. The audience is encouraged to ask scientific questions. Our postdoc was present in "Sleep Zone" and engaged with school kids between grades 7 and 11. There she answered questions on our research, sleep, circadian rhythms and other neurological disorders. Also she discussed issues related to the brain and medical research in general.
This online event provides a platform for school kids to get closer to scientists. They are very interested in our work in the brain, as well as the scientists who do the research. We hope that we inspire them go enter the research field themselves. To quote responses from two of the participants, "I know more about sleep now", "I really like you, thank you for chatting with us." It was an inspiring event for both the participants and our postdoc.
Year(s) Of Engagement Activity 2018
 
Description IMI2 Workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Workshop on new developments in home cage phenotyping and automated image analysis. Several presentations covering numerous aspects of automated phenotyping. Major discussions followed on how to take these ideas forward in terms of software and hardware development.
Year(s) Of Engagement Activity 2016
 
Description Invited Talk, IIT Italy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Further collaboration

More collaborative work and publications
Year(s) Of Engagement Activity 2013
 
Description Invitee Systems Genetics, Prague 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Interest into how our Unit can interact with community in complex trait genetics

More interest in Unit activities
Year(s) Of Engagement Activity 2013
 
Description MP Unit visits 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Unit visits from particular focus groups (WI and 3rd Age retirees). Given opportunity to carry out some simple experiments followed by presentation on application to our research. Discussions afterwards.

Similar visits are being organised for the future.
Year(s) Of Engagement Activity 2010,2011
 
Description MRC Festival 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact We manned a stand explaining some of our research and explaining some of the science behind circadian rhythms and sleep. Interaction with public and had many interactive props for public engagement. Lots of interested individuals and many additional questions on the topic.
Year(s) Of Engagement Activity 2016
 
Description MRC Harwell Open Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Public given demonstration on DNA purification and information on structure. Many interested parties with questions.

heigthened awareness in public.
Year(s) Of Engagement Activity 2013
 
Description MRC Harwell festival Open Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact We manned a stand where we exhibited some of our research and talked with the public about our work in sleep and circadian rhythms. There was a lot of interest in sleep and chronotypes.
Year(s) Of Engagement Activity 2018
 
Description Measuring Behaviour presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Presentation of new home cage phenotyping apparatus to individuals in industry, academics etc. Provoked discussions in home-cage phenotyping and developed interest in apparatus being used.
Year(s) Of Engagement Activity 2016
URL http://www.measuringbehavior.org/mb2016/home
 
Description Medical Genetics Summer School 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Lectures on Microarray Analysis and Non-Coding RNAs with detailed discussions afterward

Increased interest from students
Year(s) Of Engagement Activity 2012
 
Description Mouse Genetics Course 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Lectures on ENU mutagenesis and behavioural genetics. Followed by Q&A and general discussion.

Increased knowledge of Genetics research tools brought back to many Eastern European, Asian and African countries.
Year(s) Of Engagement Activity 2010,2011
 
Description Mouse Genetics lecture (UCL) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact Presented history and background on mouse genetics to UCL undergraduates.
Year(s) Of Engagement Activity 2016,2017,2018
 
Description Mouse Genetics, Trieste 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Talks on mouse behavioural genetics and on genetic basis of circadian rhythms. Audience was a mix of students and professionals from developing countries. Level of engagement was very high with many interesting questions and debates following the talks.
Year(s) Of Engagement Activity 2017
 
Description NEW SCIENTIST LIVE 2017, London 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Stand at Science Museum, London presenting our work on sleep and circadian rhythms. Interaction and discussions with members of the general public including schoolchildren.
Year(s) Of Engagement Activity 2017
 
Description New Statesman piece 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact New Statesman interviewee asked for comments on how London Underground night tube at weekends might affect resident mouse sleep patterns. Resulting piece published in New Statesman.
Year(s) Of Engagement Activity 2016
URL http://www.newstatesman.com/culture/nature/2016/08/how-night-tube-could-give-london-s-mice-friday-fe...
 
Description Oxford MRC Harwell Postdoc Symposium 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Our postdocs initiated and organised a Postdoctoral fellow networking event. Audience was encouraged to present their work and research interests. At the end of the symposium, there was a career advice and networking section to encourage postdocs and final year postgraduate students to establish independent collaborations.
Year(s) Of Engagement Activity 2018
 
Description Oxford Neurodevelopment Group 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Presented our work on mouse mutant models of intellectual disability
Year(s) Of Engagement Activity 2017
 
Description Oxford Neuroscience course 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Lecture on Mouse Behavioural Genetics for Masters students in Neuroscience. Led to more questions and discussion.
Year(s) Of Engagement Activity 2016,2017
 
Description Oxford Pharmacology talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Presentation of work to a mix of undergraduates, graduates and staff in the Pharmacology Department in Oxford. Discussions on work and potential collaborations afterwards.
Year(s) Of Engagement Activity 2018
 
Description Oxford Science festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact We manned a stand at Oxford Science Festival, stand was in Broad Street in Oxford city centre, open to all comers. We had lots of engagement activities which explained the science behind circadian rhythms and sleep. We had many and varied interesting discussions with the public and arranged a school visit based on some of these discussions. Through interactions with local teachers we organised a trip to the Unicorn School for a school awareness presentation.
Year(s) Of Engagement Activity 2016
 
Description Presentation IAT Oxford branch 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Informal meeting of local branch of animal technologists, attended by approximately 50 people. Many questions and informal discussion afterwards.

Good feedback from Animal Facilities Management staff.
Year(s) Of Engagement Activity 2011
 
Description Presentation at LASA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Presentation on our developments in automated home-cage phenotyping. Interest in all sections of the audience, with many questions and discussion afterwards.
Year(s) Of Engagement Activity 2016
 
Description Public engagement on twitter via the twitter account @LaBioauLabo 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Discussion of neurobehavioural genetics work via twitter
Year(s) Of Engagement Activity 2017
 
Description Royal Institute Family Fun Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact As part of the Royal institute family fun day, we had an exhibition of our work at the Royal institute, London, as one of a number of UKRI representatives. It was an open day event, attended by general public. Our postdocs were present and engaged with the general public, discussing the impact of our work on metabolism, circadian rhythms, sleep and their impact on the brain.
Year(s) Of Engagement Activity 2019
 
Description Royal Society of Medicine Symposium on Genetics of Sleep 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Health professionals
Results and Impact Presentation on how genetic models can inform us on the aetiology of sleep disorders. Led to interesting discussions on the future use of mice to model sleep disorders in humans.

Promotion of the utility of animal models amongst clinicians and other healthcare professionals.
Year(s) Of Engagement Activity 2012
 
Description SGDP King's College Molecular Biology Summer School 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Presentation as part of a course in Genetics for students, with discussion afterwards

Increased interest in behavioural genetics
Year(s) Of Engagement Activity 2009,2010,2012
 
Description School presentation, Oxford 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Schools
Results and Impact 40 students attended talk after which there were questions and discussion

Students asked for more information, investigated websites related to research topic
Year(s) Of Engagement Activity 2013
 
Description Science Festival at Cheney School, Oxford 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact We demonstrated science 'experiments' for all students there. Our group showed how the light microscope is used to examine Golgi-stained neurons.
Year(s) Of Engagement Activity 2017
 
Description Sleep presentations, Japan 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Presentations on molecular genetic basis of rhythms and sleep. Led to numerous questions and discussions.
Year(s) Of Engagement Activity 2016
 
Description Sleep talk, Bologna 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Talk on genetics of circadian rhythms and sleep. Sparked questions and discussion.
Year(s) Of Engagement Activity 2016
 
Description St Annes Open Day Talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Talk was attended by a mixture of individuals associated with St Annes College in Oxford. Open discussion afterwards on the social implications of circadian rhythm disturbances..

Highlighted impact of this growing field of research to a mixed audience
Year(s) Of Engagement Activity 2012
 
Description Summer school 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Over 50 postgraduate students in sleep and circadian neuroscience from Europe attended a series of lectures, debates and social activities. Lectures on the genetics of sleep promoted discussions in this area.

Increased interest in our work on sleep and rhythms.
Year(s) Of Engagement Activity 2014
URL http://www.eye.ox.ac.uk/research/sleep-and-circadian-neuroscience-summer-schools-2014
 
Description Super Science Saturday, Oxford 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact We were one of a number of stands at the Oxford University Natural History Museum. The focus was on the brain and we discussed our work with the public and had numerous associated demonstrations/leaflets etc.
Year(s) Of Engagement Activity 2017
 
Description Techniplast visit 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Industry/Business
Results and Impact Presented our progress with mouse home-cage tracking for sleep and activity measures
Year(s) Of Engagement Activity 2017
 
Description U3A presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Third sector organisations
Results and Impact Presentation of work to a group of U3A visitors, there was a lot of interest in biological clocks and how they change with age, illness and environmental factors.
Year(s) Of Engagement Activity 2018
 
Description UCL ION talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Talk on molecular genetics of sleep in mice. Had several questions and discussions afterwards.
Year(s) Of Engagement Activity 2016
 
Description UCL Mouse Genetics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Undergraduate students
Results and Impact Talk on Mouse Genetics with specific reference to neurological and behavioural genetics.
Year(s) Of Engagement Activity 2017
 
Description Unicorn School visit 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact School presentation on the brain.
Year(s) Of Engagement Activity 2016
 
Description Visit by Chinese research group 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presented summaries of work projects ongoing in the group.
Year(s) Of Engagement Activity 2018
 
Description Worldcon75, poster and talk presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Presentation of our research at SciFi international conference. Explanation of what we do in lay terms, led to some great interactions with the public. Postdoc, Nora Bourbia, won prize for her presentation.
Year(s) Of Engagement Activity 2017
 
Description York University visit 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Undergraduate students
Results and Impact Talk at York University with students, graduates and academics attending. Discussion on behavioural genetics as outcome.
Year(s) Of Engagement Activity 2016