Bone and Joint: Musculoskeletal disease (osteoporosis, sarcopenia and osteoarthritis)

Lead Research Organisation: MRC Lifecourse Epidemiology Unit

Abstract

We have demonstrated that the risk of osteoporotic fracture might be altered by environmental influences acting during critical periods of intrauterine life, e.g. maternal nutrition, smoking and exercise. Our future research programme builds on these observations and attempts to delineate the underlying mechanism for these associations, as well as potential interventions in young women aiming to optimize skeletal health in their offspring.

Technical Summary

Epidemiological evidence has accumulated that the risk of osteoporotic fracture might be modified by environmental influences acting during critical periods of intrauterine or early postnatal life. Thus, we have established that birthweight and weight at one year are determinants of adult bone mass and osteoporotic fracture, independently of other adult risk factors such as cigarette smoking, alcohol consumption, exercise and calcium nutrition. Preliminary data suggest important interactions between birthweight and certain genes which predict adult bone mass (such as those for growth hormone and vitamin D receptor). Our mother-offspring studies have confirmed that maternal smoking, low maternal fat stores and high maternal physical activity in late gestation, are independently associated with reduced neonatal bone mineral in the offspring. In addition, sub-optimal maternal vitamin D status (prevalence 25%) is associated with impaired placental calcium transport and significantly reduced whole body bone mineral content in the offspring at birth and 9 years. We have started to elucidate the molecular mechanisms underlying these observations. Thus epigenetic changes allow environmental factors to influence gene expression and provide a mechanism linking early life factors to later health and disease. Our future research programme builds on these observations. Having established that the environment during early life influences the later risk of osteoporotic fracture, we need to: (a) gain a greater understanding of interactions between genetic markers of osteoporosis, the intrauterine/early postnatal environment, and adult lifestyle, as determinants of bone strength, propensity to skeletal trauma and fracture risk; (b) characterise the endocrine and metabolic perturbations in humans which mediate the effect of the early environment; (c) identify the precise, modifiable, environmental characteristics responsible for poor skeletal and muscle development (for example, maternal vitamin D status or physical activity); (d) understand the mechanisms through which these characteristics alter long-term growth and body composition, at both system and molecular level (for example, epigenetic changes influencing placental calcium transport); and (e) construct a platform for intervention studies in young women aiming to optimize skeletal health in the offspring: Thus, using a randomised controlled trial, we are exploring the role of vitamin D supplementation of pregnant women to optimize bone strength in the offspring; a further intervention study is examining the impact on infant health of a complex intervention aimed at improving mothers lifestyle and diet before and during pregnancy. In linkage with NIHR Biomedical Research Unit, University of Oxford, we shall study the lifecourse epidemiology of osteoarthritis and arthroplasty. Our research into sarcopenia now forms a new programme which addresses the mechanisms underlying the developmental origins of sarcopenia, and aims to identify inter-relationships between sarcopenia and frailty, and determine the effect of these on receipt of hospital care in older people.

Organisations

Publications

10 25 50
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Abrahamsen B (2015) Life Expectancy in Patients Treated for Osteoporosis: Observational Cohort Study Using National Danish Prescription Data. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

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Akesson K (2013) Capture the Fracture: a Best Practice Framework and global campaign to break the fragility fracture cycle. in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

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Armbrecht G (2015) Vertebral Scheuermann's disease in Europe: prevalence, geographic variation and radiological correlates in men and women aged 50 and over. in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

 
Title ASBMR slide kit and videos 
Description ASBMR slide kit and videos 
Type Of Art Film/Video/Animation 
Year Produced 2016 
Impact ASBMR slide kit and videos 
 
Title ASBMR slide kit and videos 2017 
Description ASBMR slide kit and videos 2017 
Type Of Art Film/Video/Animation 
Year Produced 2017 
Impact ASBMR slide kit and videos 
 
Title ASBMR webinar (NCH) 
Description Webinar on abstract writing 
Type Of Art Film/Video/Animation 
Year Produced 2018 
Impact Improved abstract writing 
 
Title DXA video UK Biobank 
Description DXA video UK Biobank 
Type Of Art Film/Video/Animation 
Year Produced 2014 
Impact DXA video UK Biobank 
 
Title IOF webinars NHC, CC 
Description Webinar on osteoporosis prevention 
Type Of Art Film/Video/Animation 
Year Produced 2018 
Impact Improved care 
 
Title International Osteoporosis Foundation Slide kit/ videos: WCO 
Description Slide kit and video interviews based on science presented at 2015 World Congress in Osteoporosis 
Type Of Art Film/Video/Animation 
Year Produced 2015 
Impact Widely viewed 
 
Title International Osteoporosis Foundation Video 
Description International Osteoporosis Foundation Video 
Type Of Art Film/Video/Animation 
Year Produced 2014 
Impact International Osteoporosis Foundation Video 
 
Title International Osteoporosis Foundation:Slide kit and videos: ASBMR 
Description Production of slide kit and video interviews based on science presented at the 2015 ASBMR scientific meeting. 
Type Of Art Film/Video/Animation 
Year Produced 2015 
Impact Widely viewed. 
 
Title LifeLab 
Description Picture 
Type Of Art Image 
Year Produced 2014 
Impact LifeLab 
 
Title National Osteoporosis Society Video 
Description National Osteoporosis Society Video 
Type Of Art Film/Video/Animation 
Year Produced 2014 
Impact National Osteoporosis Society Video 
 
Title Osteoarthritis webinar 
Description Osteoarthritis webinar 
Type Of Art Film/Video/Animation 
Year Produced 2014 
Impact Osteoarthritis webinar 
 
Title WCO slide kit and videos 2016 
Description WCO slide kit and videos 2016 
Type Of Art Film/Video/Animation 
Year Produced 2016 
Impact WCO slide kit and videos 2016 
 
Title WCO slide kit and videos 2017 
Description WCO slide kit and videos 2017 
Type Of Art Film/Video/Animation 
Year Produced 2017 
Impact WCO slide kit and videos 2017 
 
Description ASBMR Professional Practice Committee
Geographic Reach North America 
Policy Influence Type Membership of a guideline committee
Impact Provision of bone densitometry with ISCD and IOF.
 
Description Arthritis Research UK (Fellowships Committee)
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact As a member of the ARUK Clinical Studies Group in Metabolic Bone Disease, I reviewed several large, randomised controlled trials and fellowship applications answering important questions within musculoskeletal medicine.
 
Description Can we identify patients with high risk of osteoporosis progression who will respond to treatment?
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact Improved management of osteoarthritis
 
Description Chair, International Osteoporosis Foundation (Scientific Committee) [Prof C Cooper]
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guidance committee
Impact Multiple reports and guidelines on: 1) fracture incidence worldwide; 2) trends in hip fracture worldwide over time; 3) variation in vitamin D status worldwide; 4) hazards of long-term anti-osteoporosis therapy; 5) definition of inadequate clinical response; 6) guidelines for management of glucocorticoid-induced osteoporosis. All published as peer reviewed guidance and position papers (Osteoporosis International, 2011/12).
 
Description Chair, MRC Population Health Science Research Network (Prof C Cooper)
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
Impact National advice to UK Department of Health on behaviour change; population science; national public health strategy.
 
Description Commented on NICE Bisphosphonate MTA
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
 
Description Contribution of MAVIDOS findings to SACN consultation/ PHE guidance
Geographic Reach National 
Policy Influence Type Citation in other policy documents
Impact Improved understanding of the need for vitamin D supplementation at the population level, particularly in winter months.
 
Description Contribution to SACN vitamin D guidance
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description Contribution to many government advisory panels, eg SACN, DoH, NICE
Geographic Reach National 
Policy Influence Type Participation in advisory committee
Impact Osteoporosis international and national guidelines.
 
Description European Working Group: Osteoarthritis
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guidance committee
Impact European guidelines for the management of osteoarthritis.
 
Description European regulatory guidelines for osteoarthritis
Geographic Reach Europe 
Policy Influence Type Citation in other policy documents
Impact Improved management of osteoarthritis
 
Description FRAX-based intervention thresholds
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
Impact Improved management of osteoporosis
 
Description Global Alliance for Musculoskeletal Disease
Geographic Reach Multiple continents/international 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
Impact Global Alliance for Musculoskeletal Disease
 
Description Guidelines for osteonecrosis of the jaw
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact Improved management of osteoporosis
 
Description IOF Guideline Working Group: Biochemical Markers
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guidance committee
Impact International guidelines on use of biochemical bone turnover markers.
 
Description IOF Guideline Working Group: Epidemiology
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guidance committee
Impact Characterisation of global burden of osteoporosis and development of European and international guidelines for osteoporosis care.
 
Description IOF Guideline Working Group: Secondary Fracture Prevention
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guidance committee
Impact International guideline for establishment of secondary fracture prevention services (Capture the Fracture).
 
Guideline Title IOF guidelines for the management of ONJ
Description IOF guidance on ONJ
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in clinical guidelines
Impact IOF guidelines on ONJ
 
Guideline Title Use of FRAX Risk Assessment System in management of osteoporosis
Description IOF/WHO/ISCD Osteoporosis Guidelines
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in clinical guidelines
Impact Widespread utilisation of FRAX algorithm in North America, Europe, Latin America, Asia, Middle-East and Africa.
 
Description Influence on national vitamin D policy, DH, NICE, SACN
Geographic Reach National 
Policy Influence Type Participation in a national consultation
Impact Recommendation of vitamin D supplementation in pregnancy, reduced risk of early adverse events related to vitamin D insufficiency.
 
Description Lifecourse nutrition for musculoskeletal ageing
Geographic Reach Europe 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
Impact Improved management of osteoporosis
 
Description MRC Cohort Strategy
Geographic Reach National 
Policy Influence Type Citation in other policy documents
Impact National overview of MRC cohorts.
 
Description MRC Guidance on Process Evaluation
Geographic Reach Asia 
Policy Influence Type Membership of a guidance committee
Impact MRC guidance for process evaluatoin
 
Description Management of glucocorticoid osteoporosis
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact Improved management of osteoporosis
 
Description Map of Medicine OP and Vitamin D
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
Impact Improved and more efficient treatment of osteoporosis and vitamin D deficiency
 
Description NICE
Geographic Reach National 
Policy Influence Type Membership of a guidance committee
Impact Co-authorship and citation in NICE Technology Appraisal on primary and secondary fracture prevention as well as NICE Clinical Guideline on fracture risk assessment. Publication of editorial (BMJ; 2012)
 
Description NICE Guideline Development Group: Osteoporosis
Geographic Reach National 
Policy Influence Type Membership of a guidance committee
Impact Published guideline for treatment of postmenopausal osteoporosis.
 
Description NICE OP
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description NOGG revised guidance
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
Impact Guidance on assessment and treatment of osteoporosis
 
Guideline Title National Osteoporosis Guideline Group
Description NOGG; revised thresholds
Geographic Reach National 
Policy Influence Type Citation in clinical guidelines
Impact Optimized fracture risk assessment
 
Description National Osteoporosis Guideline Group
Geographic Reach National 
Policy Influence Type Membership of a guidance committee
Impact National guideline on use of clinical risk factors and DXA assessment of bone density to target treatment for osteoporosis. Guideline published.
 
Description National Osteoporosis Guideline Group 2017 (NCH)
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description National Osteoporosis Society
Geographic Reach National 
Policy Influence Type Participation in a national consultation
Impact As Chairman of the Board of Trustees of this national charity, I gave evidence to the House of Lords Select Committee on Ageing, as well as contributing written responses on water fluoridation and musculoskeletal research over the period 2007-2009.
 
Guideline Title National Osteoporosis Society Vitamin D Guidelines 2013
Description National Osteoporosis Society Vitamin D Guidelines 2013
Geographic Reach National 
Policy Influence Type Citation in clinical guidelines
Impact Extensive feedback
 
Description Participation on NIHR Report "Better Beginnnings"
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description RCOG guidance on Vitamin D in pregnancy
Geographic Reach National 
Policy Influence Type Citation in clinical reviews
 
Description Risk detection for osteoporosis progression
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact Improved management of osteoporosis
 
Description SACN guidance 2016
Geographic Reach National 
Policy Influence Type Citation in other policy documents
Impact Improved vitamin D guidance
 
Description Scientific Advisory Committee on Diet and Nutrition- Public Health England Vitamin D Guidance (NCH)
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description Secondary fracture prevention
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact Improved management of osteoporosis
 
Description The position of strontium in today's management of osteoporosis
Geographic Reach Europe 
Policy Influence Type Citation in other policy documents
Impact Improved management of osteoporosis
 
Description Use of symptomatic slow-acting drugs in knee osteoarthritis
Geographic Reach Europe 
Policy Influence Type Citation in other policy documents
Impact Improved management of osteoarthritis
 
Description WHO European Ministerial Conference 2016
Geographic Reach Multiple continents/international 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
Impact Report on lifecourse and health
 
Guideline Title Risk assessment and treatment of osteoporosis
Description WHO Risk Assessment Methodology in UK.
Geographic Reach Asia 
Policy Influence Type Citation in clinical guidelines
Impact Widespread utilisation of FRAX algorithm within UK and companion publication (Osteoporosis International; 2011)
 
Description . European Research on Developmental, Birth and Genetic Determinants of Ageing (collaborative project).
Amount £329,977 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 04/2012 
End 03/2015
 
Description A pragmatic randomised controlled trial of the effectiveness and cost-effectiveness of screening for osteoporosis in older women for the prevention of fractures (SCOOP)
Amount £3,424,229 (GBP)
Funding ID G0601019 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2007 
End 03/2014
 
Description A randomised, double-blind, placebo controlled trial of vitamin D supplements for pregnant women with low levels of vitamin D in early pregnancy (MAVIDOS)
Amount £652,127 (GBP)
Organisation Versus Arthritis 
Start 03/2008 
End 12/2013
 
Description ARUK CRF Dr Mark Edwards
Amount £230,000 (GBP)
Organisation Versus Arthritis 
Start 10/2011 
End 09/2014
 
Description ARUK Clinical PhD Studentship: Dr Mark Edwards. Understanding the early life and environmental determinants of bone strength and structure using participants from the Hertfordshire Cohort Study.
Amount £240,424 (GBP)
Organisation Versus Arthritis 
Start 09/2011 
End 08/2014
 
Description Academic Clinical Fellowship Starter Grant
Amount £10,000 (GBP)
Organisation University of Southampton 
Sector Academic/University
Country United Kingdom
Start 05/2015 
End 12/2016
 
Description Arthritis Research UK Centre of Excellence for Sport and Exercise Injuries
Amount £76,000 (GBP)
Organisation Versus Arthritis 
Department Arthritis Research UK Centre for Sport, Exercise and Osteoarthritis
Sector Charity/Non Profit
Country United Kingdom
Start 10/2013 
End 09/2018
 
Description Arthritis Research UK Centre of Excellence for Sport and Exercise Injuries
Amount £2,500,000 (GBP)
Organisation Versus Arthritis 
Start 04/2013 
End 03/2018
 
Description Arthritis Research UK Centre of Excellence in Epidemiology
Amount £2,402,000 (GBP)
Organisation Versus Arthritis 
Start 01/2013 
End 12/2018
 
Description Arthritis Research UK Centre of Excellence in Epidemiology
Amount £120,410 (GBP)
Organisation Versus Arthritis 
Start 10/2013 
End 09/2018
 
Description Arthritis Research UK Clinical Studies Grant
Amount £362,894 (GBP)
Funding ID 21231 
Organisation Versus Arthritis 
Start 09/2016 
End 09/2021
 
Description BHF Research Training Fellowship
Amount £231,716 (GBP)
Funding ID FS/17/81/33318 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2018 
End 10/2021
 
Description BLF Project Grant
Amount £119,533 (GBP)
Organisation British Lung Foundation (BLF) 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2006 
End 12/2010
 
Description BUPA project grant MAVIDOS
Amount £142,686 (GBP)
Organisation BUPA 
Department BUPA Foundation
Sector Private
Country United Kingdom
Start 10/2009 
End 09/2012
 
Description Biomedical Research Centre Nutrition - Respiratory Research with Prof R Read et al
Amount £15,000,000 (GBP)
Organisation National Institute for Health Research 
Department NIHR Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start  
 
Description CRUK Project Grant
Amount £46,130 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2006 
End 12/2006
 
Description Clinical Research Fellowship
Amount £164,135 (GBP)
Organisation Versus Arthritis 
Start 04/2006 
End 03/2009
 
Description Clinical Research Training Fellowship
Amount £252,397 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2016 
End 08/2019
 
Description Clinical Research Training Fellowship
Amount £252,397 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2016 
End 08/2019
 
Description Cohort Resources Facility
Amount £1,000,000 (GBP)
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 05/2012 
End 04/2017
 
Description Collaborative Project Grant: National Clinical Audit of Rheumatoid & Early Inflammatory Arthritis. Collaborative project with BSR and Northgate.
Amount £172,500 (GBP)
Organisation The Health Quality Improvement Partnership (HQIP) 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2013 
End 01/2016
 
Description Data Management Planning for Secure Services (DMP-SS)
Amount £99,904 (GBP)
Organisation Jisc 
Sector Public
Country United Kingdom
Start 01/2011 
End 12/2012
 
Description Describing habitual levels of physical activity (PA) in older people in terms of impact loads and how this relates to bone and other symptoms (VIBE)
Amount £184,576 (GBP)
Funding ID MR/K024973/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 12/2013 
End 11/2016
 
Description EPOSA
Amount £225,057 (GBP)
Organisation Porticus 
Sector Charity/Non Profit
Country Global
Start 12/2013 
End 11/2016
 
Description EPOSA/Porticus foundation
Amount £450,000 (GBP)
Organisation Porticus 
Sector Charity/Non Profit
Country Global
Start 01/2009 
End 12/2012
 
Description EPSRC Project Grant: Handheld microindentation - a direct assessment of bone fracture risk?
Amount £475,000 (GBP)
Funding ID EP/J008192/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 05/2012 
End 04/2015
 
Description ERA HDHL
Amount £1,200,000 (GBP)
Funding ID BB/P028179/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 04/2017 
End 02/2020
 
Description EU Collaborative Project: Food based solutions for Optimal vitamin D Nutrition and health through the life cycle (ODIN)
Amount € 5,980,000 (EUR)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 11/2013 
End 10/2017
 
Description Epigenetic biomarkers and determinants of cardiovascular risk in children (With Prof M Hanson et al)
Amount £1,400,000 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2016 
End 03/2020
 
Description Epigenetic mechanisms linking maternal pre-conceptional micronutrient supplementation with offspring health in India and The Gambia
Amount £486,087 (GBP)
Funding ID MR/N006208/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2015 
End 04/2018
 
Description Epigenetic modification of glucocorticoid receptors by early life events
Amount £103,532 (GBP)
Organisation Chief Scientist Office 
Sector Public
Country United Kingdom
Start 01/2007 
End 12/2008
 
Description Equipment grant
Amount £145,282 (GBP)
Organisation Versus Arthritis 
Start 01/2009 
End 12/2009
 
Description FSA contract
Amount £338,993 (GBP)
Organisation Food Standards Agency (FSA) 
Sector Public
Country United Kingdom
Start 01/2006 
End 12/2007
 
Description FSA contract
Amount £434,454 (GBP)
Organisation Food Standards Agency (FSA) 
Sector Public
Country United Kingdom
Start 03/2007 
End 02/2010
 
Description Fellowship/IOF
Amount £20,000 (GBP)
Organisation International Osteoporosis Foundation 
Sector Charity/Non Profit
Country Switzerland
Start 01/2006 
End 12/2006
 
Description HTA Project Grant: Risks and benefits of bisphosphonate use in patients with chronic kidney disease
Amount £340,485 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 06/2015 
End 05/2017
 
Description Health risks and benefits of extended working life (the HEAF study)
Amount £841,392 (GBP)
Organisation University of Southampton 
Department ESRC National Centre for Research Methods
Sector Charity/Non Profit
Country United Kingdom
Start 03/2013 
End 02/2018
 
Description IOF-Servier Young Investigator Research Grant
Amount € 40,000 (EUR)
Organisation Servier Laboratories 
Sector Private
Country France
Start 01/2012 
End 12/2013
 
Description Improving pregnancy outcome in obese women
Amount £1,999,770 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2008 
End 03/2013
 
Description Joint IALSA/HALCyon Program Project: Integrative analysis of longitudinal studies of aging
Amount $7,700,000 (USD)
Organisation National Institute on Aging 
Sector Public
Country United States
Start 03/2013 
End 02/2018
 
Description MRC Capital Award
Amount £134,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 03/2018 
End 03/2019
 
Description MRC Capital Funding
Amount £310,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2017 
End 03/2018
 
Description MRC Capital Funding
Amount £288,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2015 
 
Description MRC Capital Prioritisation Award
Amount £134,000 (GBP)
Organisation University of Southampton 
Department MRC Lifecourse Epidemiology Unit
Sector Public
Country United Kingdom
Start 03/2019 
End 03/2022
 
Description MRC Capital/infrastructure (including equipment
Amount £60,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2013 
End 12/2014
 
Description MRC Centenary Award
Amount £45,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2012 
End 12/2013
 
Description MRC Lifecourse Epidemiology Unit (and linked programme grants)
Amount £14,400,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2015 
End 03/2020
 
Description MRC UUP Capital Award
Amount £288,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 03/2015 
End 03/2015
 
Description Manualising Individual Placements Support for people with unemployment due to chronic pain and testing the feasibility of a randomised controlled trial.
Amount £317,300 (GBP)
Funding ID 15/108 
Organisation National Institute for Health Research 
Department NIHR Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 01/2017 
End 03/2019
 
Description Maths, Engineering & Life Sciences: making connections for precision medicine (with Prof Deborah Mackay et al)
Amount £500,000 (GBP)
Funding ID MC_PC_15078 
Organisation Medical Research Council (MRC) 
Department MRC Human Nutrition Research Unit
Sector Public
Country United Kingdom
Start 03/2016 
End 02/2018
 
Description Maths, Engineering and Life Sciences: making connections for precision medicine
Amount £500,000 (GBP)
Funding ID MC_PC_15078 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 03/2016 
End 02/2018
 
Description Mid-Career Equipment Grant: Dr Kumaran Kalyanaraman
Amount £60,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2013 
End 12/2014
 
Description NIHR
Amount £43,129 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 01/2010 
End 07/2012
 
Description NIHR BRU: Nutrition, Diet and Lifestyle
Amount £4,000,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2008 
End 03/2012
 
Description NIHR Biomedical Research Centre in Nutrition
Amount £9,600,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2012 
End 03/2017
 
Description NIHR Biomedical Research Unit
Amount £315,517 (GBP)
Organisation National Institute for Health Research 
Department NIHR Southampton Respiratory Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 04/2008 
End 03/2012
 
Description NIHR Biomedical Research Unit: Musculoskeletal Disease
Amount £6,000,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 03/2012 
End 02/2019
 
Description NIHR HTA
Amount £317,327 (GBP)
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 10/2017 
End 09/2020
 
Description NIHR HTA Grant
Amount £340,485 (GBP)
Organisation National Institute for Health Research 
Department NIHR Clinical Research Network (CRN)
Sector Public
Country United Kingdom
Start 06/2015 
End 05/2017
 
Description NIHR PGfAR
Amount £2,166,779 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 10/2017 
End 09/2022
 
Description NIHR SBRC Nutrition
Amount £9,000,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2012 
End 03/2019
 
Description NIHR Senior Investigator Award
Amount £75,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 10/2014 
End 09/2017
 
Description NOS Project Grant CPRD
Amount £79,905 (GBP)
Organisation National Osteoporosis Society 
Sector Learned Society
Country United Kingdom
Start 01/2014 
End 12/2016
 
Description PhD fellowship
Amount £33,000 (GBP)
Organisation The Gerald Kerkut Charitable Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2010 
End 02/2013
 
Description Programme grant: A life course approach to healthy ageing: capitalizing on the value of UK life course cohorts
Amount £1,800,000 (GBP)
Funding ID MC_U120063239 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 03/2008 
End 02/2012
 
Description Programme grant: Maternal and epigenetic determinants of cardiovascular structure and function
Amount £822,366 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2007 
End 12/2012
 
Description Programme grant: Maternal and epigenetic determinants of cardiovascular structure and function
Amount £822,366 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2007 
End 12/2012
 
Description Project Grant
Amount £3,424,230 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2007 
End 12/2014
 
Description Project Grant
Amount £129,905 (GBP)
Organisation Versus Arthritis 
Start 01/2006 
End 12/2008
 
Description Project Grant
Amount £145,382 (GBP)
Organisation Versus Arthritis 
Start 01/2009 
End 12/2009
 
Description Project Grant
Amount £44,465 (GBP)
Organisation Versus Arthritis 
Start 01/2006 
End 12/2007
 
Description Project Grant
Amount £94,000 (GBP)
Organisation UK Biobank 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2006 
End 12/2008
 
Description Project Grant
Amount £650,732 (GBP)
Organisation Versus Arthritis 
Start 01/2008 
End 12/2011
 
Description Project Grant
Amount £102,500 (GBP)
Organisation The Royal Society 
Sector Academic/University
Country United Kingdom
Start 01/2007 
End 12/2008
 
Description Project Grant
Amount £338,000 (GBP)
Organisation Food Standards Agency (FSA) 
Sector Public
Country United Kingdom
Start 01/2006 
End 12/2009
 
Description Project Grant - The Role of hospital organisation, surgical factors, and the enhanced recovery pathway, on patient outcomes and NHS costs following primary hip and knee replacement surgery: spacial and longitudinal analysis of routine data
Amount £510,503 (GBP)
Funding ID 14/46/02 
Organisation National Institute for Health Research 
Department NIHR Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 04/2016 
End 03/2018
 
Description Project Grant/The Colt Foundation
Amount £135,167 (GBP)
Organisation The Colt Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2006 
End 12/2007
 
Description Project Grant: Dr Christopher Holroyd. How do pre- and post-natal environmental factors and parental bone mass influence offspring bone size and density
Amount £85,000 (GBP)
Organisation Southampton Rheumatology Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2011 
End 09/2013
 
Description Project Grant: Musculoskeletal health and extended working life
Amount £180,014 (GBP)
Organisation Versus Arthritis 
Start 10/2012 
End 09/2014
 
Description Project grant
Amount £134,496 (GBP)
Organisation Versus Arthritis 
Start 02/2006 
End 01/2008
 
Description Project grant
Amount £418,192 (GBP)
Organisation Food Standards Agency (FSA) 
Sector Public
Country United Kingdom
Start 04/2006 
End 03/2010
 
Description Project grant
Amount £328,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 11/2017 
End 09/2020
 
Description Project grant
Amount £384,000 (GBP)
Organisation Age UK 
Department Research into Ageing Fund (RiAF)
Sector Charity/Non Profit
Country United Kingdom
Start 09/2006 
End 08/2010
 
Description Project grant: Epigenetic biomarkers and determinants of cardiovascular risk in children
Amount £1,400,000 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2016 
End 03/2020
 
Description RS Project grant
Amount £102,500 (GBP)
Organisation The Royal Society 
Sector Academic/University
Country United Kingdom
Start 01/2006 
End 12/2006
 
Description Research Project Grant: Describing habitual levels of physcial activity (PA) in older people in terms of impact loads and how this relates to bone and other symptoms.
Amount £184,576 (GBP)
Funding ID MR/K024973/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2013 
End 12/2016
 
Description Senior Lecturership
Amount £365,767 (GBP)
Organisation Versus Arthritis 
Start 01/2007 
End 12/2012
 
Description Travelling Fellowship
Amount £44,465 (GBP)
Organisation Versus Arthritis 
Start 04/2006 
End 03/2007
 
Description UK Biobank Imaging
Amount £9,600,000 (GBP)
Funding ID MC_PC_12027 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2014 
End 12/2015
 
Description UK Biobank Imaging Full Funding
Amount £32,000,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 03/2016 
End 04/2022
 
Description UK Centre of Excellence for Musculoskeletal Health and Work
Amount £1,400,000 (GBP)
Organisation Versus Arthritis 
Start 12/2014 
End 11/2019
 
Description University Unit Capital Equipment Award
Amount £118,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2013 
End 12/2014
 
Description University Unit Partnership Grants: Epigenetic processes and the developmental origins of health and disease
Amount £841,392 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 09/2013 
End 08/2018
 
Description Wellcome Trust Collaborative Award
Amount £1,600,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2018 
End 09/2023
 
Description Wellcome Trust People Award
Amount £29,699 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2008 
End 03/2009
 
Title Batman 
Description Bayesian analysis of epigenome-wide methylation 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2014 
Provided To Others? Yes  
Impact Bayesian analysis of epigenome-wide methylation 
 
Title Epidemiology of Sporting Injuries 
Description Sporting injury database for elite championship professional soccer club. 
Type Of Material Biological samples 
Provided To Others? No  
Impact Decline in serious injury incidence; promotion to premiership expected. 
 
Title Health Conversation Skills 
Description Peer-led behaviour change intervention package 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2017 
Provided To Others? Yes  
Impact New Zealand, South Africa, India, Australia Modification of dietary pattern and reduction of adiposity 
 
Title Healthy conversation skills 
Description Peer-led behavioural package to enhance optimal nutritional choices among young women of childbearing age. 
Type Of Material Improvements to research infrastructure 
Year Produced 2011 
Provided To Others? Yes  
Impact Worldwide utilisation of behaviour change package. 
 
Title Hertfordshire Cohort Study 
Description Cohort Study 
Type Of Material Biological samples 
Year Produced 2006 
Provided To Others? Yes  
Impact Papers 
 
Title Hertfordshire Cohort Study 
Description Range of phenotypic data, DNA and posterity blood samples. 
Type Of Material Biological samples 
Year Produced 2006 
Provided To Others? Yes  
Impact Numerous publications (see list for details). 
 
Title High resolution peripheral quantitative computed tomography 
Description Obtains virtual bone biopsy 
Type Of Material Improvements to research infrastructure 
Year Produced 2014 
Provided To Others? Yes  
Impact Obtains virtual bone biopsy 
 
Title Hipmorph 
Description Automated assessment of hip OA 
Type Of Material Improvements to research infrastructure 
Year Produced 2014 
Provided To Others? Yes  
Impact Automated assessment of hip OA 
 
Title Kneemorph 
Description Automated system for evaluation of radiographic knee OA. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact Reproducible severity grading of osteoarthritis. 
 
Title Novel seasonal adjustment for vitamin D concentrations 
Description Novel method for adjusting the vitamin D concentrations for season, independent of assays used. 
Type Of Material Model of mechanisms or symptoms - human 
Provided To Others? No  
Impact Tracking of 25-hydroxyvitamin D status during pregnancy: the importance of vitamin D supplementation. Moon RJ, Crozier SR, Dennison EM, Davies JH, Robinson SM, Inskip HM, Godfrey KM, Cooper C, Harvey NC. Am J Clin Nutr. 2015 Nov;102(5):1081-7. doi: 10.3945/ajcn.115.115295. 
 
Title SWS Data and samples 
Description Large collection of data and samples from women and children in the Southampton Women's Survey 
Type Of Material Biological samples 
Year Produced 2006 
Provided To Others? Yes  
Impact All the SWS publications. Further grant funding for research within the SWS and for interventions arising out of it. 
 
Title Complex multi source datasets 
Description Complex multi source datasets 
Type Of Material Data analysis technique 
Provided To Others? No  
Impact Complex multi source datasets 
 
Title Epigenetic microarray data distribution 
Description Epigenetic microarray data distribution 
Type Of Material Data analysis technique 
Provided To Others? No  
Impact Epigenetic microarray data distribution 
 
Title EuroHealth Ageing 
Description EuroHealth Ageing 
Type Of Material Database/Collection of data 
Year Produced 2014 
Provided To Others? Yes  
Impact Mechanisms of ageing 
 
Title Fourier adjusted calcidiol 
Description Novel approach to adjustment of 25(OH)D for season, allowing combination of differing assays 
Type Of Material Data analysis technique 
Provided To Others? No  
Impact Published manuscript 
 
Title Growth modelling 
Description Growth modelling 
Type Of Material Data analysis technique 
Provided To Others? No  
Impact Growth modelling 
 
Title Hierarchical Data Modelling 
Description Hierarchical Data Modelling 
Type Of Material Data analysis technique 
Provided To Others? No  
Impact Hierarchical Data Modelling 
 
Title NIH VDSOP 
Description Participation, through ODIN, in NIH vitamin D standardisation procedures. 
Type Of Material Data handling & control 
Provided To Others? No  
Impact Ongoing 
 
Description ALPHABET 
Organisation Erasmus University Rotterdam
Country Netherlands 
Sector Academic/University 
PI Contribution Epigenetic determinants of bone development
Collaborator Contribution Epigenetic determinants of body composition and cognition
Impact N/A
Start Year 2016
 
Description ALPHABET 
Organisation National Institute of Health and Medical Research (INSERM)
Department Center for Epidemiological and Bio Statistics Research at Sorbonne
Country France 
Sector Public 
PI Contribution Epigenetic determinants of bone development
Collaborator Contribution Epigenetic determinants of body composition and cognition
Impact N/A
Start Year 2016
 
Description ALPHABET 
Organisation University College Dublin
Department School of Physics
Country Ireland 
Sector Academic/University 
PI Contribution Epigenetic determinants of bone development
Collaborator Contribution Epigenetic determinants of body composition and cognition
Impact N/A
Start Year 2016
 
Description ALPHABET 
Organisation University College Dublin
Country Ireland 
Sector Academic/University 
PI Contribution WP5, bone outcomes
Collaborator Contribution Consortium
Impact Ongoing
Start Year 2017
 
Description ALPHABET 
Organisation University of Bristol
Department Biomedical Research Unit in Nutrition, Diet and Lifestyle
Country United Kingdom 
Sector Hospitals 
PI Contribution Epigenetic determinants of bone development
Collaborator Contribution Epigenetic determinants of body composition and cognition
Impact N/A
Start Year 2016
 
Description ALPHABET 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution WP5, bone outcomes
Collaborator Contribution Consortium
Impact Ongoing
Start Year 2017
 
Description ALPHABET 
Organisation University of South Carolina
Department Arnold School of Public Health
Country United States 
Sector Academic/University 
PI Contribution Epigenetic determinants of bone development
Collaborator Contribution Epigenetic determinants of body composition and cognition
Impact N/A
Start Year 2016
 
Description ALSPAC placenta 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Placental determinants of bone mass
Collaborator Contribution Placental determinants of bone mass
Impact Ongoing
Start Year 2013
 
Description ARUK MAVIDOS collaboration 
Organisation University College Cork
Country Ireland 
Sector Academic/University 
PI Contribution Scientific collaboration
Collaborator Contribution Scientific collaboration
Impact 3 papers
Start Year 2013
 
Description ARUK MAVIDOS collaboration 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution DXA Lead
Collaborator Contribution Other imaging
Impact 1 paper
Start Year 2014
 
Description ARUK/MRC Centre of Excellence in Work and Musculoskeletal Disorders 
Organisation University of Liverpool
Department School of Medicine Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution Research collaboration
Collaborator Contribution Research collaboration
Impact PhD students
Start Year 2015
 
Description ARUK/MRC Centre of Excellence in Work and Musculoskeletal Health 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution Research collaboration
Collaborator Contribution Research collaboration
Impact PhD students
Start Year 2015
 
Description ARUK/MRC Centre of Excellence in Work and Musculoskeletal Health 
Organisation University of Oxford
Department School of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Research collaboration
Collaborator Contribution Research collaboration
Impact PhD students
Start Year 2015
 
Description AUGMENT UK Biobank collaboration 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution AUGMENT UK Biobank collaboration
Collaborator Contribution AUGMENT UK Biobank collaboration
Impact AUGMENT UK Biobank collaboration
Start Year 2017
 
Description AUGMENT UK Biobank collaboration 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution AUGMENT UK Biobank collaboration
Collaborator Contribution AUGMENT UK Biobank collaboration
Impact AUGMENT UK Biobank collaboration
Start Year 2017
 
Description CPRD 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution UK Osteoporosis Epidemiology
Collaborator Contribution UK Osteoporosis Epidemiology
Impact UK Osteoporosis Epidemiology
Start Year 2014
 
Description Danish Population Registry 
Organisation University of Southern Denmark
Country Denmark 
Sector Academic/University 
PI Contribution Scientific collaboration
Collaborator Contribution Scientific collaboration
Impact 2 papers
Start Year 2013
 
Description Danish Population Registry 
Organisation University of Southern Denmark
Country Denmark 
Sector Academic/University 
PI Contribution Scientific collaboration
Collaborator Contribution Scientific collaboration
Impact 2 papers
Start Year 2013
 
Description Department of Public Health, Cambridge 
Organisation University of Cambridge
Department Department of Public Health and Primary Care
Country United Kingdom 
Sector Academic/University 
PI Contribution Research Colaboration
Collaborator Contribution Research Collaboration
Impact Clinical Impact
Start Year 2008
 
Description Dr Alireza Moayyeri 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Research Collaboration
Collaborator Contribution Research Collaboration
Impact Clinical Impact
Start Year 2009
 
Description Dr Ann Prentice 
Organisation Medical Research Council (MRC)
Department MRC Human Nutrition Research Unit
Country United Kingdom 
Sector Public 
PI Contribution Research Collaboration
Collaborator Contribution Research Collaboration
Impact Clinical Impact
Start Year 2009
 
Description Dr Barbara Boucher 
Organisation Queen Mary University of London
Department Barts and The London School of Medicine and Dentistry
Country United Kingdom 
Sector Academic/University 
PI Contribution Research Collaboration
Collaborator Contribution Research Collaboration
Impact Clinical Impact
Start Year 2008
 
Description Dr Brent Richards 
Organisation McGill University
Country Canada 
Sector Academic/University 
PI Contribution Research Collaboration
Collaborator Contribution Research Collaboration
Impact Clinical Impact
Start Year 2008
 
Description Dr Francis Finucane 
Organisation University of Cambridge
Department MRC Epidemiology Unit
Country United Kingdom 
Sector Multiple 
PI Contribution Research collaboration
Collaborator Contribution Research collaboration
Impact Clinical impact
Start Year 2009
 
Description Dr Geeta Mishra 
Organisation University College London
Department MRC Unit for Lifelong Health and Ageing
Country United Kingdom 
Sector Public 
PI Contribution Research Collaboration
Collaborator Contribution Research Collaboration
Impact Clinical Impact
Start Year 2007
 
Description Dr Jonathan Reeve 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Research Collaboration
Collaborator Contribution Research Collaboration
Impact Clinical Impact
Start Year 2006
 
Description Dr Ken Ong 
Organisation University of Cambridge
Department MRC Epidemiology Unit
Country United Kingdom 
Sector Multiple 
PI Contribution Research Collaboration
Collaborator Contribution Research Collaboration
Impact Clinical impact
Start Year 2008
 
Description Dr Natascha van Schoor 
Organisation University of Amsterdam
Country Netherlands 
Sector Academic/University 
PI Contribution Research Collaboration
Collaborator Contribution Research Collaboration
Impact Clinical Impact
Start Year 2008
 
Description Dr Rebecca Hardy 
Organisation University College London
Department MRC Unit for Lifelong Health and Ageing
Country United Kingdom 
Sector Public 
PI Contribution Research Collaboration
Collaborator Contribution Research Collaboration
Impact Clinical Impact
Start Year 2006
 
Description Dr Ruth Loos 
Organisation University of Cambridge
Department MRC Epidemiology Unit
Country United Kingdom 
Sector Multiple 
PI Contribution Research collaboration
Collaborator Contribution Research collaboration
Impact Clinical impact
Start Year 2007
 
Description EPOSA 
Organisation Free University of Amsterdam
Country Netherlands 
Sector Academic/University 
PI Contribution Collaborative science.
Collaborator Contribution Collaborative science.
Impact 5 papers
Start Year 2013
 
Description EU EarlyNutrition 
Organisation Ludwig Maximilian University of Munich (LMU Munich)
Department University Clinic of Munich
Country Germany 
Sector Academic/University 
PI Contribution Work package leadership
Collaborator Contribution Overall collaboration management
Impact 1: Moon RJ, Crozier SR, Dennison EM, Davies JH, Robinson SM, Inskip HM, Godfrey KM, Cooper C, Harvey NC. Tracking of 25-hydroxyvitamin D status during pregnancy: the importance of vitamin D supplementation. Am J Clin Nutr. 2015 Nov;102(5):1081-7. doi: 10.3945/ajcn.115.115295. Epub 2015 Sep 23. PubMed PMID: 26399867; PubMed Central PMCID: PMC4634223. 2: Vogel C, Parsons C, Godfrey K, Robinson S, Harvey NC, Inskip H, Cooper C, Baird J. Greater access to fast-food outlets is associated with poorer bone health in young children. Osteoporos Int. 2015 Oct 12. [Epub ahead of print] PubMed PMID: 26458387. 3: Moon RJ, Harvey NC, Cooper C. ENDOCRINOLOGY IN PREGNANCY: Influence of maternal vitamin D status on obstetric outcomes and the fetal skeleton. Eur J Endocrinol. 2015 Aug;173(2):R69-83. doi: 10.1530/EJE-14-0826. Epub 2015 Apr 10. Review. PubMed PMID: 25862787. 4: Cleal JK, Day PE, Simner CL, Barton SJ, Mahon PA, Inskip HM, Godfrey KM, Hanson MA, Cooper C, Lewis RM, Harvey NC; SWS Study Group. Placental amino acid transport may be regulated by maternal vitamin D and vitamin D-binding protein: results from the Southampton Women's Survey. Br J Nutr. 2015 Jun 28;113(12):1903-10. doi: 10.1017/S0007114515001178. Epub 2015 May 5. PubMed PMID: 25940599; PubMed Central PMCID: PMC4498463. 5: Moon RJ, Cole ZA, Crozier SR, Curtis EM, Davies JH, Gregson CL, Robinson SM, Dennison EM, Godfrey KM, Inskip HM, Cooper C, Harvey NC; Southampton Women's Survey Study Group. Longitudinal changes in lean mass predict pQCT measures of tibial geometry and mineralisation at 6-7 years. Bone. 2015 Jun;75:105-10. doi: 10.1016/j.bone.2015.02.015. Epub 2015 Feb 20. PubMed PMID: 25703480; PubMed Central PMCID: PMC4556067. 6: Moon RJ, Harvey NC, Davies JH, Cooper C. Vitamin D and bone development. Osteoporos Int. 2015 Apr;26(4):1449-51. doi: 10.1007/s00198-014-2976-y. Epub 2014 Dec 2. PubMed PMID: 25448839. 7: Robinson SM, Crozier SR, Harvey NC, Barton BD, Law CM, Godfrey KM, Cooper C, Inskip HM. Modifiable early-life risk factors for childhood adiposity and overweight: an analysis of their combined impact and potential for prevention. Am J Clin Nutr. 2015 Feb;101(2):368-75. doi: 10.3945/ajcn.114.094268. Epub 2014 Dec 3. PubMed PMID: 25646335; PubMed Central PMCID: PMC4307207. 8: Moon RJ, Harvey NC, Davies JH, Cooper C. Vitamin D and skeletal health in infancy and childhood. Osteoporos Int. 2014 Dec;25(12):2673-84. doi: 10.1007/s00198-014-2783-5. Epub 2014 Aug 20. PubMed PMID: 25138259; PubMed Central PMCID: PMC4224585. 9: Harvey N, Dennison E, Cooper C. Osteoporosis: a lifecourse approach. J Bone Miner Res. 2014 Sep;29(9):1917-25. doi: 10.1002/jbmr.2286. Review. PubMed PMID: 24861883. 10: Harvey NC, Holroyd C, Ntani G, Javaid K, Cooper P, Moon R, Cole Z, Tinati T, Godfrey K, Dennison E, Bishop NJ, Baird J, Cooper C. Vitamin D supplementation in pregnancy: a systematic review. Health Technol Assess. 2014 Jul;18(45):1-190. doi: 10.3310/hta18450. Review. PubMed PMID: 25025896; PubMed Central PMCID: PMC4124722. 11: Curtis EM, Moon RJ, Dennison EM, Harvey NC. Prenatal calcium and vitamin D intake, and bone mass in later life. Curr Osteoporos Rep. 2014 Jun;12(2):194-204. doi: 10.1007/s11914-014-0210-7. Review. PubMed PMID: 24740166. 12: de Jongh RT, Crozier SR, D'Angelo S, Pike KC, Roberts G, Lucas JS, Inskip H, Godfrey KM, Cooper C, Harvey NC; Southampton Women's Survey Study Group. Maternal 25-hydroxyvitamin D levels in relation to offspring respiratory symptoms and infections. Eur Respir J. 2014 Apr;43(4):1181-3. doi: 10.1183/09031936.00116913. Epub 2013 Dec 12. PubMed PMID: 24337044; PubMed Central PMCID: PMC3973533. 13: Harvey NC, Cooper C. Vitamin D status and ill health. Lancet Diabetes Endocrinol. 2014 Apr;2(4):e9. doi: 10.1016/S2213-8587(14)70045-2. PubMed PMID: 24703059.
Start Year 2012
 
Description EULAR Centre of Excellence in Rheumatology 
Organisation University Hospital Southampton NHS Foundation Trust
Country United Kingdom 
Sector Hospitals 
PI Contribution Enhanced collaboration
Collaborator Contribution Enhanced collaboration
Impact Various publications.
Start Year 2010
 
Description Epidemiology Maastricht 
Organisation Maastricht University (UM)
Country Netherlands 
Sector Academic/University 
PI Contribution Epidemiology of fractures in UK
Collaborator Contribution Epidemiology of fractures in UK
Impact Ongoing
Start Year 2014
 
Description Epidemiology Utrecht 
Organisation Utrecht University
Country Netherlands 
Sector Academic/University 
PI Contribution Epidemiology of fractures in UK
Collaborator Contribution Epidemiology, medication use, mortality
Impact Ongoing
Start Year 2014
 
Description Epigenetic Studies 
Organisation University of Southampton
Country United Kingdom 
Sector Academic/University 
PI Contribution Research
Impact Research
 
Description Fracture Risk Assessment 
Organisation University of Sheffield
Country United Kingdom 
Sector Academic/University 
PI Contribution Fracture Risk Assessment
Collaborator Contribution Fracture Risk Assessment
Impact Fracture Risk Assessment
Start Year 2014
 
Description GEFOS 
Organisation Genetic Factors for Osteoporosis Consortium (GEFOS)
Country Netherlands 
Sector Charity/Non Profit 
PI Contribution Samples
Collaborator Contribution Genetic analysis
Impact ongoing
Start Year 2010
 
Description GIANT and MAGIC Consortia 
Organisation University of Cambridge
Department MRC Epidemiology Unit
Country United Kingdom 
Sector Multiple 
PI Contribution Research
Impact Research
 
Description GPRD Studies 
Organisation Utrecht University
Country Netherlands 
Sector Academic/University 
PI Contribution Research
Impact Research
 
Description Genetic Epidemiology of type 2 diabetes mellitus 
Organisation University of Cambridge
Department Department of Clinical Biochemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution Contribution of anonymised phenotypic data; statistical expertise
Impact Publication. PubMed ID: 17019603
Start Year 2006
 
Description HALCYON 
Organisation University College London
Department MRC Unit for Lifelong Health and Ageing
Country United Kingdom 
Sector Public 
PI Contribution Provision of data from Hertfordshire Cohort Study
Collaborator Contribution Multiple publications on sarcopenia and physical frailty.
Impact 3 publications
Start Year 2010
 
Description HR pQCT 
Organisation University of Southampton
Country United Kingdom 
Sector Academic/University 
PI Contribution Inflammatory disease, bone erosion
Collaborator Contribution Inflammatory disease, bone erosion
Impact Inflammatory disease, bone erosion
Start Year 2014
 
Description Helsinki Cohort Study 
Organisation University of Helsinki
Country Finland 
Sector Academic/University 
PI Contribution Research
Impact Research
 
Description Hertfordshire Cohort Study 
Organisation Johns Hopkins University
Country United States 
Sector Academic/University 
PI Contribution Research
Collaborator Contribution ResearchResearchResearchResearchResearchResearchResearchResearch
Impact Research
 
Description Hertfordshire Cohort Study 
Organisation University College London
Department MRC Unit for Lifelong Health and Ageing
Country United Kingdom 
Sector Public 
PI Contribution Research
Collaborator Contribution ResearchResearchResearchResearchResearchResearchResearchResearch
Impact Research
 
Description Hertfordshire Cohort Study 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Research
Collaborator Contribution ResearchResearchResearchResearchResearchResearchResearchResearch
Impact Research
 
Description Hertfordshire Cohort Study 
Organisation University of Amsterdam
Country Netherlands 
Sector Academic/University 
PI Contribution Research
Collaborator Contribution ResearchResearchResearchResearchResearchResearchResearchResearch
Impact Research
 
Description Hertfordshire Cohort Study 
Organisation University of Birmingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Research
Collaborator Contribution ResearchResearchResearchResearchResearchResearchResearchResearch
Impact Research
 
Description Hertfordshire Cohort Study 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Research
Collaborator Contribution ResearchResearchResearchResearchResearchResearchResearchResearch
Impact Research
 
Description Hertfordshire Cohort Study 
Organisation University of Cambridge
Department MRC Epidemiology Unit
Country United Kingdom 
Sector Multiple 
PI Contribution Research
Collaborator Contribution ResearchResearchResearchResearchResearchResearchResearchResearch
Impact Research
 
Description Hertfordshire Cohort Study 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Research
Collaborator Contribution ResearchResearchResearchResearchResearchResearchResearchResearch
Impact Research
 
Description Hertfordshire Physical Activity Intervention Trial (HPAT) 
Organisation University of Cambridge
Department MRC Epidemiology Unit
Country United Kingdom 
Sector Multiple 
PI Contribution Contribution of anonymised phenotypic data
Impact Publications. Pubmed ID: 19545359
Start Year 2006
 
Description IOF Barcelona 
Organisation Autonomous University of Barcelona (UAB)
Country Spain 
Sector Academic/University 
PI Contribution Scientific collaboration
Collaborator Contribution Scientific collaboration
Impact 3 papers
Start Year 2014
 
Description IOF vitamin D 
Organisation University of Florence
Department Department of Internal Medicine
Country Italy 
Sector Academic/University 
PI Contribution Epidemiological data
Collaborator Contribution Epidemiological data
Impact Rizzoli R et al. CMRO 2013;29:1-9.
Start Year 2011
 
Description IOF vitamin D 
Organisation University of Leuven
Department Centre for Metabolic Bone Diseases
Country Belgium 
Sector Academic/University 
PI Contribution Epidemiological data
Collaborator Contribution Epidemiological data
Impact Rizzoli R et al. CMRO 2013;29:1-9.
Start Year 2011
 
Description Improving pregnancy outcome in obese women 
Organisation Guy's and St Thomas' NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Intellectual input in design of study and development of protocol. On-going involvement in monitoring the study progress
Collaborator Contribution Collaboration with a well-respected group
Impact NIHR grant funding
Start Year 2008
 
Description LPIN1 genotype and diet 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Contribution of anonymised phenotypic data
Impact Publications. Pubmed ID: 18591397
Start Year 2007
 
Description LPIN1 genotype and diet 
Organisation University of Cambridge
Department MRC Epidemiology Unit
Country United Kingdom 
Sector Multiple 
PI Contribution Contribution of anonymised phenotypic data
Impact Publications. Pubmed ID: 18591397
Start Year 2007
 
Description LifeLab Southampton 
Organisation University of Southampton
Department School of Medicine Southampton
Country United Kingdom 
Sector Academic/University 
PI Contribution Our research findings have shown the importance of diet and lifestyle before children are even conceived, so we need to engage with children at schools to enable them to understand the importance of their behaviours now on their long-term health and that of their children
Collaborator Contribution Enabled us to contribute more effectively to public engagement in science by getting our research findings communicated to teenagers in and around Southampton
Impact Many public engagement activities with teenagers, with anecdotal marked improvement in the behaviour of some. Paper in preparation showing shifts in knowledge from before to after participating in the LifeLab activities.
Start Year 2007
 
Description Lifecourse influences on women's smoking patterns 
Organisation Lancaster University
Department Institute for Health Research
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision, coding and cleaning, grant and paper writing
Collaborator Contribution Data analysis, paper writing, grant writing
Impact 17708005, 16962221, 16476753
 
Description Lung function in 6 year old children 
Organisation University of Southampton
Department School of Medicine Southampton
Country United Kingdom 
Sector Academic/University 
PI Contribution Data collection, grant and paper writing
Collaborator Contribution Grant and paper writing. Data collection, analysis of samples
Impact Papers now submitted
Start Year 2007
 
Description MAVIDOS 
Organisation Medical Research Council (MRC)
Department MRC Human Nutrition Research Unit
Country United Kingdom 
Sector Public 
PI Contribution Research
Impact Research
Start Year 2006
 
Description MAVIDOS 
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Scientific collaboration
Collaborator Contribution Scientific collaboration
Impact 2 abstracts
Start Year 2013
 
Description MAVIDOS 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Research
Impact Research
Start Year 2006
 
Description MAVIDOS 
Organisation University of Sheffield
Country United Kingdom 
Sector Academic/University 
PI Contribution Research
Impact Research
Start Year 2006
 
Description MAVIDOS Childhood Follow up 
Organisation University of Sheffield
Country United Kingdom 
Sector Academic/University 
PI Contribution Recruitment to MAVIDOS 6 year follow-up in Sheffield
Collaborator Contribution Recruitment to MAVIDOS six-year follow-up in Sheffield
Impact N/A
Start Year 2016
 
Description MAVIDOS Childhood Follow-up Oxford 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Recruitment of children to MAVIDOS six-year follow-up in Oxford
Collaborator Contribution Recruitment of children to MAVIDOS six-year follow-up in Oxford
Impact N/A
Start Year 2016
 
Description MAVIDOS Oxford CVD 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Vitamin D in pregnancy and offspring cardiac structure and function
Collaborator Contribution Vitamin D in pregnancy and offspring cardiac structure and function
Impact Ongoing
Start Year 2015
 
Description MRC Epidemiology Unit (EU), University of Cambridge 
Organisation University of Cambridge
Department MRC Epidemiology Unit
Country United Kingdom 
Sector Multiple 
PI Contribution Research Collaboration
Collaborator Contribution Research Collaboration
Impact Clinical Impact
Start Year 2006
 
Description MRC LLHA University College London 
Organisation University College London
Department MRC Unit for Lifelong Health and Ageing
Country United Kingdom 
Sector Public 
PI Contribution Research Collaboration
Collaborator Contribution Research Collaboration
Impact Clinical Impact
Start Year 2009
 
Description MRC SCOOP Trial 
Organisation University of Birmingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Research
Impact Research
Start Year 2006
 
Description MRC SCOOP Trial 
Organisation University of East Anglia
Country United Kingdom 
Sector Academic/University 
PI Contribution Research
Impact Research
Start Year 2006
 
Description MRC SCOOP Trial 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution Research
Impact Research
Start Year 2006
 
Description MRC SCOOP Trial 
Organisation University of Sheffield
Country United Kingdom 
Sector Academic/University 
PI Contribution Research
Impact Research
Start Year 2006
 
Description MRC SCOOP Trial 
Organisation University of York
Country United Kingdom 
Sector Academic/University 
PI Contribution Research
Impact Research
Start Year 2006
 
Description Metabolic syndrome in HCS 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution Contribution of anonymised phenotypic data; statistical expertise
Impact Multiple abstracts in this field
 
Description Nigel Loveridge 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Research Collaboration
Collaborator Contribution Research Collaboration
Impact Clinical Impact
Start Year 2006
 
Description Nutrition BRU 
Organisation University of Southampton
Department Faculty of Health Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Preparation of application, administration and conduct of some of the core projects
Collaborator Contribution Allowed us to conduct complementary studies arising out of the Southampton Women's Survey
Impact Grant funding
Start Year 2008
 
Description ODIN 
Organisation University College Cork
Country Ireland 
Sector Academic/University 
PI Contribution Scientific collaboration
Collaborator Contribution Scientific collaboration
Impact 3 papers
Start Year 2013
 
Description Osteoarthritis Programme 
Organisation Imperial College London
Department Department of Epidemiology and Biostatistics
Country United Kingdom 
Sector Academic/University 
PI Contribution Research
Collaborator Contribution Novel technique for grading osteoarthritis using digitised radiographs.
Impact Research
Start Year 2006
 
Description Osteoarthritis Programme 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Research
Collaborator Contribution Novel technique for grading osteoarthritis using digitised radiographs.
Impact Research
Start Year 2006
 
Description Osteoarthritis: Health Economics 
Organisation Cedars-Sinai Medical Center
Country United States 
Sector Hospitals 
PI Contribution Epidemiological data
Collaborator Contribution Epidemiological data
Impact Hiligsmann M et al. Seminars in Arthritis and Rheumatism 2013; in press.
Start Year 2011
 
Description Osteoarthritis: Health Economics 
Organisation Diakonhjemmet Hospital
Department Department of Rheumatology
Country Norway 
Sector Hospitals 
PI Contribution Epidemiological data
Collaborator Contribution Epidemiological data
Impact Hiligsmann M et al. Seminars in Arthritis and Rheumatism 2013; in press.
Start Year 2011
 
Description Osteoarthritis: Health Economics 
Organisation Northwestern University
Department Feinberg School of Medicine
Country United States 
Sector Academic/University 
PI Contribution Epidemiological data
Collaborator Contribution Epidemiological data
Impact Hiligsmann M et al. Seminars in Arthritis and Rheumatism 2013; in press.
Start Year 2011
 
Description Osteoarthritis: Health Economics 
Organisation Royal North Shore Hospital and Kolling Institute
Country Australia 
Sector Hospitals 
PI Contribution Epidemiological data
Collaborator Contribution Epidemiological data
Impact Hiligsmann M et al. Seminars in Arthritis and Rheumatism 2013; in press.
Start Year 2011
 
Description Osteoarthritis: Health Economics 
Organisation University of Lorraine
Country France 
Sector Academic/University 
PI Contribution Epidemiological data
Collaborator Contribution Epidemiological data
Impact Hiligsmann M et al. Seminars in Arthritis and Rheumatism 2013; in press.
Start Year 2011
 
Description Osteoarthritis: Health Economics 
Organisation University of Maryland
Department Division of Rheumatology & Clinical Immunology
Country United States 
Sector Academic/University 
PI Contribution Epidemiological data
Collaborator Contribution Epidemiological data
Impact Hiligsmann M et al. Seminars in Arthritis and Rheumatism 2013; in press.
Start Year 2011
 
Description Osteoarthritis: Health Economics 
Organisation University of Ottawa
Department Faculty of Medicine
Country Canada 
Sector Academic/University 
PI Contribution Epidemiological data
Collaborator Contribution Epidemiological data
Impact Hiligsmann M et al. Seminars in Arthritis and Rheumatism 2013; in press.
Start Year 2011
 
Description Osteoarthritis: Health Economics 
Organisation VU University Medical Center
Department Department of Epidemiology and Biostatistics
Country Netherlands 
Sector Academic/University 
PI Contribution Epidemiological data
Collaborator Contribution Epidemiological data
Impact Hiligsmann M et al. Seminars in Arthritis and Rheumatism 2013; in press.
Start Year 2011
 
Description Philipp Thurner 
Organisation University of Southampton
Department Faculty of Engineering and the Environment
Country United Kingdom 
Sector Academic/University 
PI Contribution Research collaboration, bioengineering
Collaborator Contribution Biomechanical expertise
Impact Ongoing
Start Year 2011
 
Description Physical activity 
Organisation University of Cambridge
Department MRC Epidemiology Unit
Country United Kingdom 
Sector Multiple 
PI Contribution Epidemiological data
Collaborator Contribution Epidemiological data
Impact Collings PJ et al. Am J Clin Nutr 2013;97: 1020-8. Harvey NC et al. Osteoporos Int 2012;23:121-30. Hesketh KR et al. BMC Public Health 2013;13:924. McMinn AM et al. Int J Behav Nutr Phys Act 2009;6:81.
Start Year 2011
 
Description Prof Diana Kuh 
Organisation University College London
Department MRC Unit for Lifelong Health and Ageing
Country United Kingdom 
Sector Public 
PI Contribution Research Collaboration
Collaborator Contribution Research Collaboration
Impact Clinical Impact
Start Year 2009
 
Description Prof Kay-Tee Khaw 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Research Collaboration
Collaborator Contribution Research Collaboration
Impact Clinical Impact
Start Year 2008
 
Description Prof N Wareham 
Organisation University of Cambridge
Department MRC Epidemiology Unit
Country United Kingdom 
Sector Multiple 
PI Contribution Research collaboration
Collaborator Contribution Research collaboration
Impact Clinical impact
Start Year 2006
 
Description Prof Paul Lips 
Organisation University of Amsterdam
Country Netherlands 
Sector Academic/University 
PI Contribution Research Collaboration
Collaborator Contribution Research Collaboration
Impact Clinical Impact
Start Year 2007
 
Description Professor Bo Abrahamsen 
Organisation University of Southern Denmark
Department Molecular Endocrinology Laboratory (KMEB)
Country Denmark 
Sector Academic/University 
PI Contribution Population database research
Collaborator Contribution Research
Impact Ongoing
Start Year 2012
 
Description Professor Ulf Ekelund 
Organisation University of Cambridge
Department MRC Epidemiology Unit
Country United Kingdom 
Sector Multiple 
PI Contribution Research collaboration, physical activity monitoring
Collaborator Contribution Research
Impact Original papers
Start Year 2006
 
Description Relationship of aldosterone with cortisol and blood pressure 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Contribution of anonymised phenotypic data
Impact Publications. Pubmed ID: 19380612
Start Year 2006
 
Description Shape Modelling 
Organisation University of Aberdeen
Country United Kingdom 
Sector Academic/University 
PI Contribution Hip and knee shape modelling for osteoarthritis
Collaborator Contribution Hip and knee shape modelling for osteoarthritis
Impact Hip and knee shape modelling for osteoarthritis
Start Year 2014
 
Description Southampton Women's Survey 
Organisation Lancaster University
Country United Kingdom 
Sector Academic/University 
PI Contribution Research
Impact Research
 
Description Southampton Women's Survey 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Research
Impact Research
 
Description Southampton Women's Survey 
Organisation University of Bergen
Country Norway 
Sector Academic/University 
PI Contribution Research
Impact Research
 
Description Southampton Women's Survey 
Organisation University of Cambridge
Department MRC Epidemiology Unit
Country United Kingdom 
Sector Multiple 
PI Contribution Research
Impact Research
 
Description Southampton Women's Survey 
Organisation University of Oslo
Country Norway 
Sector Academic/University 
PI Contribution Research
Impact Research
 
Description Southampton Women's Survey 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Research
Impact Research
 
Description Southampton Women's Survey 
Organisation University of Southampton
Country United Kingdom 
Sector Academic/University 
PI Contribution Research
Impact Research
 
Description UK Biobank 
Organisation University of Oxford
Department School of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Research collaboration
Collaborator Contribution Research collaboration
Impact Emergent analysis of body composition and cardiovascular function in UK Biobank
Start Year 2015
 
Description UK Biobank 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution DXA Lead
Collaborator Contribution Other imaging
Impact 1 paper
Start Year 2014
 
Description UK Biobank Aberdeen 
Organisation University of Aberdeen
Country United Kingdom 
Sector Academic/University 
PI Contribution Active shape modelling of joints- epidemiology
Collaborator Contribution Active shape modelling of joints- modelling
Impact Ongoing
Start Year 2015
 
Description UK Biobank Bristol 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Determinants of bone mass and fracture risk
Collaborator Contribution Determinants of bone mass and fracture risk
Impact Ongoing
Start Year 2016
 
Description UK Biobank Sheffield 
Organisation University of Sheffield
Country United Kingdom 
Sector Academic/University 
PI Contribution DXA pixel mapping- epidemiology and UKB
Collaborator Contribution DXA pixel mapping- technical expertise
Impact Ongoing
Start Year 2015
 
Description UKB CVD OP 
Organisation Queen Mary University of London
Country United Kingdom 
Sector Academic/University 
PI Contribution UK Biobank: Associations between BMD, fracture and cardiovascular disease
Collaborator Contribution UK Biobank: Associations between BMD, fracture and cardiovascular disease
Impact UK Biobank: Associations between BMD, fracture and cardiovascular disease
Start Year 2014
 
Description University of Helsinki 
Organisation University of Helsinki
Country Finland 
Sector Academic/University 
PI Contribution Research collaboration
Collaborator Contribution Clinical Impact
Impact Clinical impact
Start Year 2006
 
Description University of Oxford 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Research Collaboration
Collaborator Contribution Research Collaboration
Impact Clinical Impact
Start Year 2007
 
Description University of Southampton 
Organisation University of Southampton
Country United Kingdom 
Sector Academic/University 
PI Contribution Research Collaboration
Collaborator Contribution Research Collaboration
Impact Clinical Impact
Start Year 2006
 
Description VIBE 
Organisation University of Bristol
Department MRC Integrative Epidemiology Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution Scientific collaboration
Collaborator Contribution Scientific collaboration
Impact 2 abstracts
Start Year 2013
 
Description WHO Clinical Consortium on Health Ageing 
Organisation World Health Organization (WHO)
Country Global 
Sector Public 
PI Contribution Contribution to World Report on Ageing and Health, and project to operationalise concept of intrinsic capacity
Collaborator Contribution Organisation of WHO workshop on intrinsic capacity
Impact WHO Global Report on Ageing and Health
Start Year 2016
 
Title DNA methylation and chronic disease 
Description Epigenetics 
IP Reference WO2010086663 
Protection Patent application published
Year Protection Granted 2010
Licensed No
Impact Papers
 
Title DNA methylation and later disease. 
Description DNA methylation at selected loci in the human genome correlated with childhood obesity, and reduced bone mass. 
IP Reference US2012040344 
Protection Patent application published
Year Protection Granted 2012
Licensed Commercial In Confidence
Impact Research contracts with Danone, Abbott and Nestle.
 
Title Epigenetic markers of body composition 
Description Phenotype prediction and predictive use of CpG methylation 
IP Reference WO2010086663 
Protection Patent granted
Year Protection Granted 2010
Licensed Commercial In Confidence
Impact Not known
 
Title Healthy conversation skills worker resource pack. 
Description Package of behavioural skills to enhance peer-led initiatives to optimise nutritional behaviour of young women. 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted 2012
Licensed Yes
Impact Multiple collaborations: Australia, USA and Canada.
 
Title Identification of perinatal epigenetic marks associated with later neuropsychological function 
Description Identification of perinatal epigenetic marks associated with later neuropsychological function. 
IP Reference WO2010086663 
Protection Patent application published
Year Protection Granted 2013
Licensed No
Impact Two abstracts and paper in preparation.
 
Title Method of predicting one or more neurodevelopmental phenotypes of a subject. 
Description Method of predicting one or more neurodevelopmental phenotypes. 
IP Reference WO2007129113 
Protection Patent application published
Year Protection Granted 2013
Licensed No
Impact Six abstracts and paper in press.
 
Title Phenotype Prediction 
Description Amended claims: total body lean mass and/or percentage lean mass or a disease condition associated therewith including sarcopenia; and impaired skeletal development associated with reduced bone mineral content or a disease condition associated with low bone mineral content such as osteoporosis. RXRA, CDKN2A 
IP Reference EU: 10150772.1 
Protection Patent application published
Year Protection Granted
Licensed No
Impact EpiGen Consortium
 
Title Phenotype Prediction: Developmental Origins of Adult Disease 
Description Phenotype Prediction. 
IP Reference EP2194143 
Protection Patent granted
Year Protection Granted 2010
Licensed Yes
Impact Epigen Consortium
 
Title Phenotype Prediction: Developmental Origins of Adult Disease 
Description Phenotype prediction. 
IP Reference EP2194143 
Protection Patent granted
Year Protection Granted 2010
Licensed Yes
Impact Epigen Consortium
 
Title Phenotype prediction by determining the methylation status of genes 
Description Methylation as prediction of phenotype 
IP Reference WO2015/067952 A1 
Protection Patent application published
Year Protection Granted
Licensed No
Impact EpiGen Consortium
 
Title Predictive use of CpG methylation 
Description RXRA for obesity or adiposity, body mass index and limb fat as an indicator of body fat distribution 
IP Reference EU: 10702168.5 
Protection Patent application published
Year Protection Granted
Licensed No
Impact EpiGen Consortium
 
Title Healthy Conversation Intervention 
Description Healthy Conversation Intervention 
Type Preventative Intervention - Behavioural risk modification
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2014
Development Status Under active development/distribution
Impact Health and Wealth impacts 
 
Title Maternal vitamin D supplementation in pregnancy 
Description MAVIDOS Trial published confirming beneficial effects of 1000 IU cholecalciferol compared with placebo on neonatal bone mass for winter births. 
Type Preventative Intervention - Nutrition and Chemoprevention
Current Stage Of Development Late clinical evaluation
Year Development Stage Completed 2017
Development Status Under active development/distribution
Clinical Trial? Yes
UKCRN/ISCTN Identifier 82927713
Impact Modification of national and international nutritional guidelines. 
 
Title Odanacatib 
Description Data Monitoring Committee for major phase III trial of Odanacatib in prevention of osteoporotic fracture. 
Type Therapeutic Intervention - Drug
Current Stage Of Development Refinement. Clinical
Year Development Stage Completed 2013
Development Status Under active development/distribution
Clinical Trial? Yes
Impact Large international phase III trial. 
URL http://clinicaltrials.gov/show/NCT00529373
 
Title Strontium ranelate and knee osteoarthritis 
Description First discovered disease-modifying agent for knee osteoarthritis 
Type Therapeutic Intervention - Drug
Current Stage Of Development Late clinical evaluation
Year Development Stage Completed 2012
Development Status Under active development/distribution
Clinical Trial? Yes
UKCRN/ISCTN Identifier European Trial (EMA registered)
Impact Attenuation of cartilage loss in OA. 
 
Title Healthy Conversation Skill Behavioural Package 
Description Peer led intervention package for young women aiming to optimize nutrition and physical activity 
Type Of Technology Webtool/Application 
Year Produced 2017 
Open Source License? Yes  
Impact Multiple use in South Africa, New Zealand, Malaysia, Singapore 
 
Description "Meet the Expert Workshop" 2-4 December 2018, Kate Ward 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Kate Ward led a "Meet the Expert Workshop" at the 2018 National Osteoporosis Society Annual Conference which took place in Birmingham from 2nd to 4th December 2018
Year(s) Of Engagement Activity 2018
 
Description 14th EUGMS Conference, Berlin, 10-11th October 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Attendance and lecture at the 14th EUGMS held on the 10-11th October in Berlin
Year(s) Of Engagement Activity 2018
 
Description 2017 World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases, Florence 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Scientific Committee Chairperson for this event in Florence, Italy on 15th June 2017. The event was captured online, twitter, facebook and email
Year(s) Of Engagement Activity 2017
 
Description 2018 National Osteoporosis Society Annual Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A number of MRC LEU investigators attended the 2018 National Osteoporosis Society Annual Conference. Young Investigator Awards were received by Beth Curtis, Millie Parsons, Michael Clynes and Nick Fuggle. Kate Ward led a Meet the Expert Workshop and Professors Cyrus Cooper and Nick Harvey also gave major invited plenary presentations. Nick and Kate are also members of the Conference Organising Committee. There was a lot of social media activity surrounding this event.
Year(s) Of Engagement Activity 2018
 
Description 28th Seah Cheng Memorial Lecture, Singapore, 15-18th September 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Cyrus was invited to give the keynote address at the Academy of Medicine, Singapore on 'Osteoarthritis - from paediatric days to geriatric times'.
Year(s) Of Engagement Activity 2018
 
Description 45th European Calcified Tissue Society Conference in Valencia from 28-29th May 2018 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Provided lecture and attendance at the 45th European Calcified Tissue Society Conference
Year(s) Of Engagement Activity 2018
 
Description 500th baby born in MAVIDOS study 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Articles announcing 500th baby born in MAVIDOS study:
Meridian TV; Southern Daily Echo; University of Southampton website.

Increased recognition of LEU science
Year(s) Of Engagement Activity 2012
 
Description 9th International Conference on Osteoporosis and Bone Disease, China 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Gave 2 lectures at the 9th International Conference on Osteoporosis and Bone Disease, chaired 2 events
Year(s) Of Engagement Activity 2018
 
Description A blog welcoming Professor Cyrus Cooper to their new trustee 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact The Medical Research Foundation added to their blog to welcome Cyrus Cooper as their new trustee. Cyrus was nominated by the MRC and his term will be until 2020
Year(s) Of Engagement Activity 2017
 
Description A press release issued for a paper which was published in the University of Southampton News and Medicalxpress 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Press release on 'Relationships between markers of inflammation and muscle mass, strength and function: Findings from the Hertfordshire Cohort Study.
Year(s) Of Engagement Activity 2017
 
Description ASBMR Annual Conference, Atlanta, USA - Plenary Lectures 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact ASBMR Annual Conference, Atlanta, USA - Plenary Lectures
Year(s) Of Engagement Activity 2016
 
Description ASBMR debate, Montreal 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Major international debate
Year(s) Of Engagement Activity 2015
 
Description ASBMR nutrition WG 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact ASBMR nutrition WG, invited presentation of MAVIDOS study
Year(s) Of Engagement Activity 2015
 
Description American Society for Bone and Mineral Research in Montreal from 28th September to 1st October 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact International Meeting in Montreal for the American Society for Bone and Mineral Research, presented a lecture and full attendance
Year(s) Of Engagement Activity 2018
 
Description Appointment to non-executive director of hospital trust 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact The University of Southampton Medicine News Page reported that Professor Cyrus Cooper has been appointed as non-executive director of hospital trust.
Year(s) Of Engagement Activity 2018
 
Description Arthritis Research Sub-Committee in Chesterfield on 23rd May 2018 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Arthritis research sub-committee meeting in Chesterfield on 23rd May 2018
Year(s) Of Engagement Activity 2018
 
Description Arthritis Research UK Pain Workshop, Wellcome Trust, London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Arthritis Research UK Pain Workshop, Wellcome Trust, London
Year(s) Of Engagement Activity 2016
 
Description Article appeared in Healio with quotes by Nick Harvey regarding findings in his paper which was published in July 2018 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact An article appeared in healio with quotes by Nick Harvey regarding the findings in his paper which was published in July 2018
Year(s) Of Engagement Activity 2018
 
Description Article attracted great deal of media attention 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Hill WD, Marioni RE, Maghzian O, Ritchie SJ, Hagenaars SP, McIntosh AM, Gale CR, Davies GA combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence. Molecular psychiatry 2018/01/11 doi 10.1038/s41380-017-0001-5.
This article attracted a great deal of media attention - as well as appearing in a number of newspapers it was tweeted by 467 people, was on 7 facebook pages, mentioned in 3 Google+ posts, picked up by 14 news outlets, 4 Reddit and 2 videos, plus 54 readers on Mendeley.
Year(s) Of Engagement Activity 2018
 
Description Article entitled "higher inflammation in older age is linked to lower bone density" appeared in the University of Southampton medicine news and in the medicalexpress website 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Article entitled "higher inflammation in older age is linked to lower bone density" appeared in the University of Southampton medicine news and in the medicalexpress website
Year(s) Of Engagement Activity 2018
 
Description Article for NRAS on Osteoporosis and Rheumatoid Arthritis (ED) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact Review article designed to promote awareness of coexistence of comorbidity in RA, leading to enquiries from interested patients via the website
Year(s) Of Engagement Activity 2010,2015
 
Description Article in National newspaper 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The Guardian newspaper published an article entitled 'Murder Mystery to DNAL researchers bring science to life in schools.' The article covered the benefits of introducing school pupils to science in a laboratory environment.
Year(s) Of Engagement Activity 2017
 
Description Article published on two websites 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This article attracted some media attention and appeared on two websites and the University of Southampton enews. The articles were entitled 'Poorer health influences muscle strength in later life'.
Year(s) Of Engagement Activity 2017
 
Description Article submitted for the 8th December edition of the Friday blog 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Karen Walker-Bone and Cyrus Cooper submitted an article entitled 'Good work is good for us'.
Year(s) Of Engagement Activity 2017
 
Description Articles on MAVIDOS findings appeared on website articles and facebook 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Articles on MAVIDOS findings appeared on the University of Southampton website, World News website; Publicnow.com. It was also mentioned on a number of Facebook pages including, University of Southampton; International Osteoporosis Foundation and Resilient Bones.
Year(s) Of Engagement Activity 2017
 
Description BBC Interview in Singapore for International News 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Cyrus Cooper gave an interview on BBC World News addressing recent advances in the risk assessment and treatment of osteoporosis.
Year(s) Of Engagement Activity 2018
 
Description BBC News: Vitamin D boosts child muscles 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Extensive feedback
Year(s) Of Engagement Activity 2014
 
Description BMFMS, Amsterdam 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact BMFMS, Amsterdam
Year(s) Of Engagement Activity 2016
 
Description Blog for the University of Southampton 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Regular broadcast while giving a talk in Geneva. It was one week after the general election. It made Cyrus more aware of the impact the election and Brexit would have on the work we do
Year(s) Of Engagement Activity 2017
 
Description Blog on global outreach of the research of the MRC LEU 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Stimulating increased interest in research globally in the research of the MRC.
Year(s) Of Engagement Activity 2017
 
Description Blog written by Cyrus Cooper and Nick Harvey which appeared in the Medically Spekaing section of the Unviersity of Southampton website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact Cyrus Cooper and Nick Harvey wrote a blog which appeared in the "Medically Speaking" section of the University of Southampton website. Their blog was about the National Osteoporosis Society Annual Osteoporosis Conference, at which four members of the MRC LEU, Beth Curtis, Millie Parsons, Nick Fuggle and Michael Clynes all received young investigator awards.
Year(s) Of Engagement Activity 2018
 
Description Bone Research Society Event Speaker and Organising Committee 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Part of the organising committee for the Bone Research Society Conference in Winchester from 27th - 30th June 2018.
Year(s) Of Engagement Activity 2018
 
Description Bone Research Society Training Course, Oxford 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Attended and ran a session at the Bone Research Society Training Course at Oxford in March 2018
Year(s) Of Engagement Activity 2018
 
Description Bone Research Society, Edinburgh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Major invited lecture
Year(s) Of Engagement Activity 2015
 
Description British Orthopedic Research Society Keynote lecture (EMD) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact British Orthopedic Research Society Keynote lecture
Year(s) Of Engagement Activity 2017
 
Description British Society for Rheumatology, Birmingham 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Major invited lecture
Year(s) Of Engagement Activity 2015
 
Description British Society of Rheumatology Annual Meeting Manchester (ED) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Chair of debate to discuss musculoskeletal aging, leading to greater awareness among colleagues and other interested parties
Year(s) Of Engagement Activity 2015
 
Description CCA Meeting, Geneva - invited lecture 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact CCA Meeting, Geneva - invited lecture
Year(s) Of Engagement Activity 2016
 
Description CTI manuscript press release (ME) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Calcified Tissue International manuscript on sarcopenia and dysmobility.
Year(s) Of Engagement Activity 2015
 
Description Calcium and Vitamin D supplementation are not associated with risk of incident ischemic cardiac events or death: findings from the UK Biobank Cohort - press release 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Press release created a lot of media interest for this paper.
Year(s) Of Engagement Activity 2018
 
Description Cheltenham Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact MRC stand at Cheltenham Science festival. LEU staff contributed/ LEU work covered

Interaction with national public audience
Year(s) Of Engagement Activity 2008,2009,2010,2011,2012
 
Description Conference IOF Florence March 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The members of the Committee of Scientific Advisors of the International Osteoporosis Foundation (IOF) and the Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) are developing a very exciting Congress' scientific programme that will bring together the world's best in the field of musculoskeletal health and disease.

We really hope to welcome you in Krakow, Poland and that this Congress will move the field one step forward on all fronts; from new understanding of bone metabolism and pathology, to new strategies and options in prevention, diagnosis and treatment.
Year(s) Of Engagement Activity 2017
 
Description Conferences 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Many talks and posters presented at a wide range of conferences

Increased communication with the scientific community and the general public about our work
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010
 
Description Cyrus Cooper and Keith Godfrey - Clarivate Highly Cited Researchers 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Both Cyrus Cooper and Keith Godfrey received congratulations for being among 2018s highly cited researchers. They were included in the Clarivate Analytics listings and also mentioned on the University of Southampton website.
Year(s) Of Engagement Activity 2018
 
Description Cyrus Cooper was interviewed for an article that was published in the Telegraph as a result of the paper that was published in the BMJ on Vitamin D. 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Cyrus Cooper was interviewed for an article that was published in the Telegraph as a result of the paper that was published in the BMJ on Vitamin D. His comments included: Cyrus Cooper, Professor of Rheumatology at the University of Southampton and President of the International Osteoporosis Foundation who contributed to the study said that bone density was probably some two to three times better at predicting someone's risk of getting osteoporosis than their level of Vitamin D level. "I don't think this paper debunks the idea that Vitamin D is useful", he said. "It's just that it is a small determinant. You'd do some good if you make sure that your Vitamin D levels are okay." Commenting on the current UK advice for management and prevention of osteoporosis he said: "The current guidelines are appropriate however a bone density evaluation needs to be done as part of fracture risk screening".
Year(s) Of Engagement Activity 2018
 
Description DOHaD World Congress, Cape Town 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lecture
Year(s) Of Engagement Activity 2015
 
Description Daily Echo MAVIDOS 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Coverage of MAVIDOS 500th baby in daily paper (Daily Echo)

Regional coverage via paper and website
Year(s) Of Engagement Activity 2012
 
Description Daily Mail vitamin D article 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview on vitamin D to inform Daily Mail research
Year(s) Of Engagement Activity 2017
 
Description Donald Acheson's Festschrift 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact 300 attendees with widespread media coverage.

Local newspaper and TV accolades.
Year(s) Of Engagement Activity 2011
 
Description Donation from Wessex Heartbeat of £200,000 in the LifeLab programme to help region's chldren lead a healthier life 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Undergraduate students
Results and Impact News of the donation was on the University of Southampton website under medicine and lifelab news, daily echo website and newspaper, and deepsouth media.
Year(s) Of Engagement Activity 2017
 
Description ECTS Conference, Rome. Keynote Lecture 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact ECTS Conference, Rome. Keynote Lecture
Year(s) Of Engagement Activity 2016
 
Description ECTS, Salzburg 13-16 May 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact ECTS, Salzburg 13-16 May
Year(s) Of Engagement Activity 2017
 
Description ESCEO Working Group, 20th March 2018 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Attendance and presented at ESCEO International Working Group on 20th March 2018
Year(s) Of Engagement Activity 2018
 
Description ESCEO Working Groups, Geneva - Invited Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Vitamin D Meeting, London - Invited Lecture
Year(s) Of Engagement Activity 2016
 
Description ESICON Congress, New Delhi. Plenary Lecture 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact ESICON Congress, New Delhi. Plenary Lecture
Year(s) Of Engagement Activity 2016
 
Description EWGSOP2/EUGMS in Amsterdam on 4th June 2018 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Supporters
Results and Impact Attendance and spoke at the EWGSOP2/EUGMS in Amsterdam on 4th June 2018
Year(s) Of Engagement Activity 2018
 
Description Edinburgh Science Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Lecture

Feedback excellent; media attention; future research informed
Year(s) Of Engagement Activity 2007,2010
 
Description Enews email University of Southampton, Faculty of Medicine and Daily Echo, Deccan Chronical and Medical Xpress 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Sarah El Heis and Cyrus Cooper submitted paper entitled 'Maternal Stress and psychological distress preconception: association with offspring atopic eczema at age 12 months' to University of Southampton Faculty of Medicine and local newspapers. This paper received media attention from the University and the Daily Echo.
Year(s) Of Engagement Activity 2017
 
Description Enews, University of Southampton: QQR renewal; and David Barker Research Prize (CC) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other audiences
Results and Impact Enews, University of Southampton: QQR renewal; and David Barker Research Prize awarded to CC.
Year(s) Of Engagement Activity 2015
 
Description Expert Opinion 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Nick Harvey answered questions from the Daily Mail regarding Vitamin D formulations
Year(s) Of Engagement Activity 2017
 
Description Expert Panel Sarcopenia, 12-14th November 2018, Boston 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Attended Expert Panel Meeting on Sarcopenia in Boston from 12-14th November 2018
Year(s) Of Engagement Activity 2018
 
Description Faculty of Medicine eNews Blog: CC 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other audiences
Results and Impact Faculty of Medicine eNews blog: CC
Year(s) Of Engagement Activity 2016
 
Description Fake Food Event Feedback 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Sian Robinson was one of the six panellists at the Fake Food event which took place at Lecture Theatre 1, SAB, Southampton General Hospital. The panel were asked questions by groups of local sixth formers who had been invited to the event.
Year(s) Of Engagement Activity 2018
 
Description Findings from the paper 'Calcium and Vitamin D supplementation are not associated with risk of incident ischemic cardiac events or death' appeared in the Hippocratic Post and other media 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Findings from the paper 'Calcium and Vitamin D supplementation are not associated with risk of incident ischemic cardiac events or death: Findings from the UK biobank cohort. J Bone Miner Res. 2018 May;33(5):803-811. doi: 10.1002/jbmr.3375, epub 2018 Feb 8'. appeared in the Hippocratic Post, on other websites, on 3 facebook pages, 34 tweets, and 1 blog.
Year(s) Of Engagement Activity 2018
 
Description General media activity 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Many interviews with journalists. Filming by various TV companies. Radio interviews and contributions to documentaries

Increased understanding of our work by the public
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010
 
Description Gestational vitamin D supplementation leads to reduced perinatal RXRA DNA methylation: results from the MAVIDOS trial - press release 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact https://www.southampton.ac.uk/medicine/news/2018/11/vitamin-d-baby-genes.page; https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbmr.3603
Gestational vitamin D supplementation leads to reduced perinatal RXRA DNA methylation: results from the MAVIDOS trial. Journal of Bone and Mineral Research. 2018 doi.10.1002/jbmr.3603
Curtis EM, Krstic N, Cook E, D'Angelo S, Crozier SR, Moon RJ, Murray R, Garratt Em, Costello P, Cleal J et al (inc Godfrey K, Cooper C and Harvey N).
Year(s) Of Engagement Activity 2018
 
Description Herfordshire Open Day in Harpenden on 23rd June 2018 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact Attendance at the Herfordshire Open Day on 23rd June in Harpenden
Year(s) Of Engagement Activity 2018
 
Description Hertfordshire Public Meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Study participants or study members
Results and Impact Approximately 300 HLS participants and their families attended an open day, which led to discussion, questions and interest in future research studies.
Year(s) Of Engagement Activity 2018
 
Description High Commissioner, Singapore 17-18th September 2018 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact During the visit he was invited to a discussion on UK-Singapore research collaborations at Eden Hall, the residence of His Excellency Mr Scott Wightman, UK High Commissioner to Singapore.
Year(s) Of Engagement Activity 2018
 
Description Horizon BBC TV 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Wide dissemination of MRC funded research.

A second BBC Horizon TV programme commissioned.
Year(s) Of Engagement Activity 2011
 
Description ICCBH presentation (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lecture on children's bone health
Year(s) Of Engagement Activity 2017
 
Description ICFSR Annual Congress, Philadelphia, Keynote Lecture 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact ICFSR Annual Congress, Philadelphia, Keynote Lecture
Year(s) Of Engagement Activity 2016
 
Description ICFSR, Barcelona 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact ICFSR, Barcelona
Year(s) Of Engagement Activity 2017
 
Description IOF CTF Webinar (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact IOF CTF Webinar
Year(s) Of Engagement Activity 2018
 
Description IOF ESCEO WCO, Florence 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact IOF ESCEO WCO, Florence
Year(s) Of Engagement Activity 2016
 
Description IOF ESCEO meeting, Geneva 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact IOF ESCEO meeting, Geneva
Year(s) Of Engagement Activity 2017
 
Description IOF Medal of Achievement Award: Prof Cyrus Cooper 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Articles announcing the award of the IOF Medal of Achievement to Prof Cyrus Cooper appeared on various websites including St Peter's College, Oxford University; University of Southampton, and www.news-medical.net/news/20120326.

Increased recognition of LEU science
Year(s) Of Engagement Activity 2012
 
Description IOF Meeting, Geneva - Invited Lecture 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact IOF Meeting, Geneva - Invited Lecture
Year(s) Of Engagement Activity 2016
 
Description IOF Regionals, Singapore, Plenary lectures and chairing commitments 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact IOF Regionals, Singapore, Plenary lectures and chairing commitments
Year(s) Of Engagement Activity 2016
 
Description IOF WCO Florence ESCEO Symposium (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lecture on imminent fracture risk in scientific symposium
Year(s) Of Engagement Activity 2017
 
Description IOF/ ESCEO working group OA (EMD) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact IOF/ ESCEO working group OA (EMD)
Year(s) Of Engagement Activity 2017
 
Description ISCD Conference, Galway, Ireland, Plenary lectures and chairing 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact ECTS Conference, Rome. Keynote Lecture
Year(s) Of Engagement Activity 2016
 
Description ITV News article (interview with CC) re "New hope for people with osteoporosis" 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact News article for published paper in Osteoporosis International 2015; 26: 1893-1901.
Year(s) Of Engagement Activity 2015
 
Description International Award for Publishing Excellence 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The authors received this international award for a paper that they published.
Year(s) Of Engagement Activity 2016
 
Description International Conference on Frailty and Sarcopenia Research, Miami, 1st - 3rd March 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Attended and presented at the International Conference on Frailty and Sarcopenia Research from 1st - 3rd March 2018
Year(s) Of Engagement Activity 2018
 
Description International Osteoporosis Foundation Congress on Osteoporosis (ED) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Workshop to disseminate information regarding current European collaboration into osteoarthritis, sparking questions and discussion
Year(s) Of Engagement Activity 2015
 
Description International publicity around vitamin D supplement study (NCH, RJM), including live BBC Scotland interview (NCH) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact International publicity around vitamin D supplement study (NCH, RJM), including live BBC Scotland interview (NCH)
Year(s) Of Engagement Activity 2019
 
Description Invited ASBMR Webinar (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited ASBMR Webinar (NCH)
Year(s) Of Engagement Activity 2018
 
Description Invited Presentation on vitamin D in pregnancy (NCH); 6th International Maternal Fetal Health congress Turkey 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on vitamin D in pregnancy (NCH); 6th International Maternal Fetal Health congress Turkey
Year(s) Of Engagement Activity 2018
 
Description Invited lecture (CC): 24th Annual Gregory Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Invited presentation on vitamin D in pregnancy, including MAVIDOS
Year(s) Of Engagement Activity 2016
 
Description Invited lecture (CC): British Rheumatology Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited presentation on vitamin D, including MAVIDOS.
Year(s) Of Engagement Activity 2016
 
Description Invited lecture (CC): ECTS, Rome 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited lecture on vitamin D in pregnancy, including MAVIDOS
Year(s) Of Engagement Activity 2016
 
Description Invited lecture (CC): ISCD, Galway, Ireland 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited lecture on vitamin D in pregnancy, including MAVIDOS
Year(s) Of Engagement Activity 2016
 
Description Invited lecture (CC): Vitamin D meeting, London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited presentation on vitamin D in pregnancy, including MAVIDOS
Year(s) Of Engagement Activity 2016
 
Description Invited lecture (NCH), European Endocrinology Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited presentation on vitamin D in pregnancy, inc MAVIDOS

Increased understanding
Year(s) Of Engagement Activity 2015
 
Description Invited lecture (NCH): European Calcified Tissue Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited presentation on vitamin D in pregnancy, inc MAVIDOS

Increased understanding
Year(s) Of Engagement Activity 2015
 
Description Invited lecture (NCH): Happy Pregnancy Conference, Tartu 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited presentation on vitamin D in pregnancy, inc MAVIDOS

Increased understanding
Year(s) Of Engagement Activity 2015
 
Description Invited lecture (NCH): ODIN, Helsinki 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited presentation on vitamin D in pregnancy, inc MAVIDOS

Increased understanding
Year(s) Of Engagement Activity 2015
 
Description Invited lectures (CC): IOF-ESCEO World Congress on Osteoporosis, Malaga 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited lectures on vitamin D in pregnancy, including MAVIDOS
Year(s) Of Engagement Activity 2016
 
Description Invited plenary presentation, Mellanby Bone Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited plenary presentation, Mellanby Bone Conference
Year(s) Of Engagement Activity 2017
 
Description Invited plenary presentation, UK Biobank Annual Conference (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited plenary presentation, UK Biobank Annual Conference (NCH)
Year(s) Of Engagement Activity 2017
 
Description Invited presentation (NCH): Stockholm Endcrine Disease in Pregnancy Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited presentation on vitamin D in pregnancy, inc MAVIDOS

Increased understanding of vitamin D in pregnancy
Year(s) Of Engagement Activity 2015
 
Description Invited presentation on vitamin D in pregnancy and lifecourse epidemiology of bone development (NCH, Bone Research Society Annual Meeting) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited presentation on vitamin D in pregnancy and lifecourse epidemiology of bone development (NCH, Bone Research Society Annual Meeting)
Year(s) Of Engagement Activity 2018
 
Description Invited speaker (NCH): Society for Endocrinology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited presentation on vitamin D in pregnancy, including MAVIDOS

Increased understanding of vitamin D in pregnancy
Year(s) Of Engagement Activity 2015
 
Description Invited talks 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Participants in your research and patient groups
Results and Impact Multiple major national and international meetings

Press conferences, scientific collaborations, grant funding and publications
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010
 
Description Invited talks at national/international conferences 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact Many talks given by various members of the team

Press releases with reports in the media
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010
 
Description LifeLab Meet the Scientist Training Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Both Becca Moon and Janis Baird attended the all day training session on LifeLab Meet the Scientist
Year(s) Of Engagement Activity 2017
 
Description LifeLab Presentation 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Dr Rebecca Moon gave a LifeLab Meet the Scientist presentation to 23 year 9 students from Petersfield School.
Year(s) Of Engagement Activity 2017
 
Description LifeLab taster events 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Visit from 8 students and three science teachers from three secondary schools in Southampton to test out a series of events that we plan to incorporate in a teaching programme for schools to improve health and diet of teenagers. In 2009 two entire classess visited and then conducted a public debate based on information they had learned

Feedback from teachers and students has helped develop the programme and contributed to our applications for funding. Local publicity and education for local school children
Year(s) Of Engagement Activity 2008,2009
 
Description Lifelab public engagement event for school children- bone health and vitamin D; Bone Research Society meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Lifelab public engagement event for school children- bone health and vitamin D; Bone Research Society meeting
Year(s) Of Engagement Activity 2018
 
Description Lister Research Prize 2017 in London on 22nd May 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation of the Lister Research Prize 2017
Year(s) Of Engagement Activity 2018
 
Description Live television interview on "That Solent" (NCH) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Live television interview covering MAVIDOS study and involvement in UK Biobank.
Year(s) Of Engagement Activity 2016
 
Description MRC Epidemiology Strategy Ref Group, Cambridge from 8th - 9th October 2018 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Attendance and participation at the MRC Epidemiology Strategy Ref Group in Cambridge from 8th - 9th October 2018
Year(s) Of Engagement Activity 2018
 
Description MRC Festival of Medical Research 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact On 23rd June 2018 a number of MRC LEU staff (Prof Cyrus Cooper, Prof Hazel Inskip, Prof Elaine Dennison, Prof Sian Robinson, Gregorio Bevilcqua, Leo Westbury, Barbara Fariborz, Martin Stevens, Tina Horsfall, Holly Syddall, Kate Ward, Shirley Simmonds, Millie Parsons, Michael Clines, Vanessa Cox, Clare Harris, Harnish Patel and Ilsa Bloom) travelled to Hertfordshire for the MRC Festival of Medical Research where they held the Hertfordshire Cohort Study Open Day at Harpenden Public Halls. There were two sessions, one in the morning and the other in the afternoon. Many of the participants of the Hertfordshire study, their children and grandchildren attended the event which included a talk by Cyrus Cooper and hands on activities - refreshments were provided. An article appeared in MRC Life and another article about the open day was sent to Charlotte Campbell at UCL to be included in the CLOSER newsletter.
Year(s) Of Engagement Activity 2018
 
Description MRC Festival of Medical Research, Southampton 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact MRC Festival of Science, Southampton
Year(s) Of Engagement Activity 2016
 
Description MRC Grant for £134K 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper and Nick Harvey were successful in securing an MRC Grant to the value of £134k which will fund a new dual energy x-ray absorptiometry (DXA) instrument and Mechanograph technology.
Year(s) Of Engagement Activity 2018
 
Description MRC LEU Centenary Event 2013 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact MRC Centenary Event open to the public, including presentations on work of the MRC over the last one hundred years, ending with a Q&A session. Led by Prof C Cooper and involving Unit staff.

Extensive feedback
Year(s) Of Engagement Activity 2013
 
Description MRC LEU Science Week 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact MRC LEU Workshop for Science Week, 14 March 2015
Year(s) Of Engagement Activity 2015
 
Description Media Interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Interview with House Beautiful magazine regarding the importance of vitamin D to health.

Increased awareness of LEU science
Year(s) Of Engagement Activity 2012
 
Description Media Interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Interview with Sainsbury's magazine regarding the importance of vitamin D to health.

Increased recognition of LEU science
Year(s) Of Engagement Activity 2012
 
Description Media Interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Interview with At Home magazine regarding the importance of vitamin D to health.

Increased recognition of LEU science
Year(s) Of Engagement Activity 2012
 
Description Media attention from release of paper 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact 'The impact of menopausal hormone therapy (MHT) on cardiac structure and function: insights from the UK biobank imaging enhancement study'. PLoS One 2018, March 8th.
Within a few days of being published this paper was within the top 5% of articles for this phenomenal almetrics score. The attention score showed 75 news outlets, 1 blog, 15 tweeters from around the world. Many newspapers picked up the story, including the Sun, The Daily Mirror, The Daily Mail, The Daily Star. It also appeared on a number of websites: Science Daily; Mayo Clinic, Queen Mary University of London, The Citizen and Deccan Chronicle, as well as those of the newspapers.
Year(s) Of Engagement Activity 2018
 
Description Media interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Interview with Daily Mail regarding importance of vitamin D for health.

Increased recognition of LEU science
Year(s) Of Engagement Activity 2012
 
Description Media press releases 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact An article entitled 'Osteoporosis genetic link found' appeared online on MSN News, Sky News, The Press Association, BBC Radio Solent, and quoted Cyrus Cooper who contributed to the study.

Increased recognition of LEU science
Year(s) Of Engagement Activity 2012
 
Description Media queries for GBD 2013 risk factor paper (CC) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Media enquiries from reporter regarding 'Global, regional and national comparative risk assessment of 79 behavioural, environmental and occupational and metabolic risks or clusters of risks in 188 countries 1990-2013; a systematic analysis for the GBD 2013'.
Year(s) Of Engagement Activity 2015
 
Description Medical Research Council News Publication 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Health professionals
Results and Impact MRC Magazine article: Osteoporosis medal for LEU director. Professor Cooper was awarded the prestigious IOF Medal of Achievement in Bordeaux, March 2012.

Increased recognition of LEU science
Year(s) Of Engagement Activity 2012
 
Description Medicine News Roundup (CC) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Media: New research led by C Cooper, University of Southampton, reveals that older people with age-related loss of muscle mass and strength may be at greater risk of falling and bone fractures.
Year(s) Of Engagement Activity 2015
 
Description Meeting for local Council and PCT members 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Policymakers/politicians
Results and Impact Presentations and discussions with members of the local council and Primary Care Trust and local influencial figures to explain the findings from the SWS and to develop collaborations for conducting research in Southampton for improving the diets and health of young women and children

Good collaboration developed and research planning commenced
Year(s) Of Engagement Activity 2008
 
Description Meeting hosted at the Unit for members of the Obesity Taskforce 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Visit from Foresight Obesity Taskforce

Contribution to the government's obesity strategy
Year(s) Of Engagement Activity 2006
 
Description Meeting of the MRC LEU Research Review Panel, 5th July 2017 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Meeting of the MRC LEU Research Review Panel. This meeting took place at the MRC LEU and was chaired by Councillor Ivan White and presentations were given by Councillor Sarah Bogle, about her visit to LifeLab, Mary Barker on EACh-B and Elaine Dennison on The Hertfordshire Integration Study.
Year(s) Of Engagement Activity 2017
 
Description Meeting with NOS President and Chief Executive of Canada 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Meeting with the NOS President and Chief Executive of Canada at Dukes Hotel, London on 23rd March 2018
Year(s) Of Engagement Activity 2018
 
Description Menopause Conference, Prague - Plenary Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Menopause Conference, Prague - Plenary Lecture
Year(s) Of Engagement Activity 2016
 
Description Multiple press releases and media coverage on MAVIDOS vitamin D paper published in the Lancet Diabetes & Endocrinology, 1 March 2016 [CC, NCH et al] 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Large media coverage on paper published in the Lancet Diabetes and Endocrinology. Cooper C, Harvey N et al. Maternal gestational vitamin D supplementation and offspring bone health (MAVIDOS): a multicentre, double-blind, randomised placebo-controlled trial.
Year(s) Of Engagement Activity 2016
 
Description NEWS: Dr Christopher Bell led the largest sequencing based analysis to date of genetically driven epigenetic variation in the human genome. 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact NEWS: Dr Christopher Bell (MRC-LEU & IDS), in collaboration with King's College London and BGI Shenzhen, has led the largest sequencing-based analysis to date of genetically driven epigenetic variation in the human genome. This work, published in Nature Communications, has implications for the functional dissection of common disease associated regions, as well as the interpretation of DNA methylation population studies.
Year(s) Of Engagement Activity 2018
 
Description NHS 70 Years 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact NHS 70 years in London on 9th April
Year(s) Of Engagement Activity 2018
 
Description NOS Public Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Lecture
Year(s) Of Engagement Activity 2015
 
Description New Forest Rotary Club Donation 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact New Forest Rotary Club enabled all Hounsdown School's Year 9 pupils to take part in the Lifelab programme thanks to a grant of £1,300 which funded the transport from school to the University of Southampton's LifeLab at the Biomedical Research Centre. The children thoroughly enjoyed the experience.
Year(s) Of Engagement Activity 2017
 
Description New Twitter Account 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Elizabeth Curtis sent an email to MRC LEU staff letting them know that the MRC LEU now has its own twitter account
Year(s) Of Engagement Activity 2017
 
Description News Article (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation of MAVIDOS at ASBMR. Picked up scientific press in US.

Increased awareness of vitamin D in early life
Year(s) Of Engagement Activity 2015
 
Description News articles (CC): Chubby babies face a lifetime of medical problems including obesity 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact News articles (CC): Chubby babies face a lifetime of medical problems including obesity. Press articles appeared in Mail Online, Daily Mail.
Year(s) Of Engagement Activity 2015
 
Description News item on Meridian Tonight: Children have strong muscles if mothers have vitamin D 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Extensive feedback
Year(s) Of Engagement Activity 2014
 
Description Newsletter Hertfordshire 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Developed a newsletter for participants in the Hertfordshire Cohort Study

Enables participants to be updated on findings from the latest research as well as informed on forthcoming studies
Year(s) Of Engagement Activity 2008
 
Description Newspaper article 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Published article in The Daily Mail. 'Can you get osteoporosis from being too thin?'

Increased recognition of LEU science
Year(s) Of Engagement Activity 2012
 
Description Newspaper article: Higher vitamin D may results in stronger kids 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Extensive feedback
Year(s) Of Engagement Activity 2014
 
Description Newspaper interview (Daily Mail): Microindentation 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Interview covered a new microindentation technique currently being tested at the University of Southampton and MRC LEU.

Extensive feedback
Year(s) Of Engagement Activity 2013
 
Description Newspaper interview (Daily Mail, NCH) Vitamin D 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Increased understanding of vitamin D
Year(s) Of Engagement Activity 2014
 
Description Novel technique helps identify diabetic patients at risk of bone fracture (ME) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Various media coverage on the legions and virtual bone biopsy stories.
Year(s) Of Engagement Activity 2016
 
Description Osteoporosis Dorset (EMD) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Osteoporosis Dorset
Year(s) Of Engagement Activity 2017
 
Description Osteoporosis Review Editorial 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Entry for PURE: Editorial work: Elaine wrote an editorial for Osteoporosis Review. The Journal of the National Osteoporosis Society.
Year(s) Of Engagement Activity 2018
 
Description Osteoporosis Summit Meeting, Armenia, Keynote Lectures and Government Advisory Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Osteoporosis Summit Meeting, Armenia, Keynote Lectures and Government Advisory Meeting
Year(s) Of Engagement Activity 2016
 
Description Osteoporosis Update Meeting, Bournemouth. Invited Lecture 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Osteoporosis Update Meeting, Bournemouth. Invited Lecture
Year(s) Of Engagement Activity 2016
 
Description Osteoporosis article (Holland & Barrett Healthy Magazine 2013) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact This article, led by Dr Harvey, gives an overview of the important of osteoporosis and how it may be affected by diet.

Extensive feedback
Year(s) Of Engagement Activity 2013
 
Description Paget's Information Event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Third sector organisations
Results and Impact Approximately 50 patients attended for an information afternoon, with Professor Elaine Dennison, which sparked questions and discussion with patients reporting better knowledge of their condition.
Year(s) Of Engagement Activity 2018
 
Description Paper appeared online in December 2017 after its press release, further media attention on 1.2.18 in MIMS 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This paper first appeared online in December 2017 after its press release. However, in 2018 it received further media attention on 1.2.18 in MIMS with an article entitled GP-led screening reduces hip fracture risk in older women and on 2.3.18 in Medical Health News net an article entitled FRAX: a nuanced tool for predicting fracture risk. There were also 149 tweets and 28 retweets.
Year(s) Of Engagement Activity 2018
 
Description Paper published on various websites, facebook and twitter 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Paper entitled 'Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis, submitted for publication in Nature Genetics by N Harvey and C Cooper. This paper received a great deal of attention from around the world on various websites, facebook and twitter.
Year(s) Of Engagement Activity 2017
 
Description Paper received a great deal of media interest, appearing on a number of websites 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact McLachlan JJ, Gale CR.
The effects of psychological distress and its interaction with socioeconomic position on risk of developing four chronic diseases. Journal of Psychosomatic Research. 2018; 109: 79-85.
This paper received a great deal of media interest, appearing on a number of websites, including: University of Southampton, the Daily Mail, University Hospitals Southampton, the Sun, ITV News, Medical News Today, reachmd.com, managed health care executive.com, anxious minds, the star and archyworldys. An article also appeared in the Daily Echo.
Year(s) Of Engagement Activity 2018
 
Description Paper receiving much media atttention on various websites, facebook and twitter 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis, printed in Nature Genetics and receiving international attention
Year(s) Of Engagement Activity 2017
 
Description Plenary invited presentation Managing Osteoporosis Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Plenary invited presentation Managing Osteoporosis Conference
Year(s) Of Engagement Activity 2017
 
Description Plenary invited presentation at DOHAD World Congress (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Plenary invited presentation at DOHAD World Congress
Year(s) Of Engagement Activity 2017
 
Description Plenary presentation, International Conference on Children's Bone Health, Wurzburg (NCH)