Epigenetic Epidemiology

Lead Research Organisation: University of Bristol

Abstract

This programme aims to gain a better understanding of the determinants and consequences of epigenetic variation through the use of epidemiological approaches. We will extend our knowledge of the relationship between common genetic variation and DNA methylation across the genome through large scale GWAS analysis. The identification of genetic variants that tag methylation variation will enhance our ability to conduct Mendelian randomization to strengthen causal inference. We will develop our use of DNA methylation as a biomarker of disease prediction and prognosis as well as an index of exposure to disease risk factors. Lastly, we will combine these elements of the programme and other methodological advances in epigenetic epidemiology to address a variety of disease specific research questions.

Technical Summary

Background: To maximally exploit the rapid pace of change, including the accrual of large-scale data, in the field of epigenetic epidemiology, we will develop innovative methods for the robust scientific interrogation of population-based epigenetic data and apply them to research questions of scientific and medical importance, structured around four domains:
Aim 1: We will explore the genetic architecture of epigenetic traits and use this information to understand the role that DNA methylation variation plays in health and disease.
Aim 2: We will develop and make readily accessible the causal analysis methods and tools and apply Mendelian randomization (MR) to epigenetic questions.
Aim 3: We will use DNA methylation as an index of past exposures to improve our prediction of disease risk and prognosis.
Aim 4: From neurodevelopment to cancer, there are a multitude of settings in which we can apply epigenetic epidemiology to understand disease mechanisms and predict disease.
Methods: We will utilize multiple data sources; from in-house studies, via collaborations and consortia, and through publicly accessible repositories. Our primary focus will be on the analysis of DNA methylation, as this continues to be the most readily available source of epigenetic data in population-based studies. However, we will integrate these data with newly generated and publicly available epigenomic and transcriptomic data, tissue-specific data and histone modification data.
A wide range of methods will be applied. These include mQTL analysis, functional annotation and machine learning approaches, such as penalized regression, support vector machines, and neural networks. We will test for mediation using MR and apply our prediction methods in disease relevant datasets.
Translation: The output arising from this programme will be used to develop biomarkers of disease risk and disease prognosis. It will also shed light on the genetic architecture of DNA methylation and the causal role this molecular phenotype plays in development and disease, which will in turn inform future interventions.

Organisations

Publications

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Cecil CAM (2018) DRD4 methylation as a potential biomarker for physical aggression: An epigenome-wide, cross-tissue investigation. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

 
Description Creating a West African BioResource for Nutritional Genetics and Epigenetics (C Relton)
Amount £186,171 (GBP)
Funding ID MC_PC_MR/R020183/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2018 
End 12/2018
 
Description De Pass Vice Chancellor's Fellowship - Rebecca Richmond
Amount £260,000 (GBP)
Organisation University of Bristol 
Sector Academic/University
Country United Kingdom
Start 10/2018 
End 10/2022
 
Description HDR UK RCUK Innovation/Rutherford Fellowships - Two fellowships (C Relton)
Amount £614,457 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 02/2018 
End 01/2021
 
Title GARFIELD - J.Min 
Description Josine Min has developed a novel approach that leverages genome-wide association studies' findings with regulatory or functional annotations to classify features relevant to a phenotype of interest. GARFIELD classifies disease-relevant genomic features through integration of functional annotations with association signals 
Type Of Material Improvements to research infrastructure 
Year Produced 2019 
Provided To Others? Yes  
Impact This tool has been cited in at least 21 publications. 
URL https://www.ebi.ac.uk/birney-srv/GARFIELD/
 
Title Meffil - J.Min 
Description Josine Min and other researchers have developed a new tool for performing quality control and preprocessing large sets of DNA methylation profiles used in epidemiological studies. Previous tools were unable to process such large datasets without requiring high-end computational resources. Our tool may also be used to improve statistical power in meta-analyses. 
Type Of Material Improvements to research infrastructure 
Year Produced 2018 
Provided To Others? Yes  
Impact This package has been used to analyse 36 datasets from the GoDMC consortium. It has been cited by 7 publications. 
URL https://github.com/perishky/meffil#meffil
 
Title EWAS Catalog 
Description A database of epigenome-wide association studies with seacrh tool 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
Impact None as yet 
URL http://www.ewascatalog.org
 
Title Genetics of DNA methylation Consortium (GoDMC) - Josine Min 
Description As part of the GoDMC (Genetics of DNA methylation Consortium) we have generated a database which contains all discovered mQTL associations. It also has a dalliance genome browser to explore regional features of the association. 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? No  
Impact We have developed a github pipeline for the GoDMC consortium. So far, 36 different groups have processed and analysed their data and uploaded the results to our sftp server. 
 
Title Identification of differentially methylated regions 
Description This software tool improves on previous work by properly controlling false positive rates, providing support for meta-analysis and increasing statistical power 
Type Of Material Data analysis technique 
Year Produced 2019 
Provided To Others? Yes  
Impact None as yet 
 
Description ALPHABET 
Organisation University College Dublin
Department School of Public Health, Physiotherapy and Population Science
Country Ireland 
Sector Academic/University 
PI Contribution I am a co-investigator on a ERA-HDHL (BBSRC) collaborative research project on the influence of early life nutrition on offspring health led by UCD. Our contribution includes collating multi-centre epigenetic data, running epigenome-wide association studies, meta-analyses and causal analysis methods.
Collaborator Contribution The partners in this collaboration contribute data from various large birth cohort studies and expertise in nutrition and other clinical disciplines
Impact No outputs to report
Start Year 2017
 
Description Alcohol_exposure 
Organisation University of Toronto
Department Baycrest Centre for Geriatric Care
Country Canada 
Sector Hospitals 
PI Contribution joint analysis of ALSPAC (epigenetic) data and imaging phenotypes obtained by Toronto group
Collaborator Contribution imaging phenotypes obtained by Toronto group
Impact No output yet, but expected in 2017
Start Year 2016
 
Description Biogen Idec 
Organisation Biogen Idec
Department MR and Epigenetics Industry Translation
Country United Kingdom 
Sector Private 
PI Contribution We have hosted and visited Biogen Idec to pursue collaborative links around discovery science in epigenetics.
Collaborator Contribution Invitation to contribute to a Genomics Workshop at Biogen Idec and liaison regarding future collaboration
Impact A collaborative agreement is being formulated.
Start Year 2013
 
Description Columbia University, NY 
Organisation Columbia University
Department Mental Health, Causal Epidemiology
Country United States 
Sector Academic/University 
PI Contribution My research team interact with Prof Ezra Susser at Columbia University on various aspects of epigenetics research. This involves face-to-face meetings, teleconferences and email correspondence.
Collaborator Contribution Prof Susser brings expertise in epidemiology and psychiatry.
Impact No specific outputs to record in this reporting period. Grant applications have been submitted but have not been successful.
Start Year 2013
 
Description Copenhagen University 
Organisation Copenhagen University Hospital
Country Denmark 
Sector Hospitals 
PI Contribution We bring epigenetic epidemiology expertise. This collaboration is focused around the exploration of DNA methylation as an intermediate linking cigarette smoke exposure to a wide range of health outcomes.
Collaborator Contribution The collaborators bring access to and biosamples from their very large population based resources, namely the Copenhagen City Heart Study
Impact Manuscripts under submission and further papers are in preparation.
Start Year 2013
 
Description ESRC Biomarker Data Project Fellowship in Understanding Society - R Richmond 
Organisation University of Essex
Department Institute for Social and Economic Research, Essex
Country United Kingdom 
Sector Academic/University 
PI Contribution Data analysis of Understanding Society data.
Collaborator Contribution Data provision for Understanding Society and mentorship.
Impact Rebecca Richmond was awarded an ESRC fellowship.
Start Year 2018
 
Description European Bioinformatics Institute 
Organisation EMBL European Bioinformatics Institute (EMBL - EBI)
Country United Kingdom 
Sector Academic/University 
PI Contribution We bring epidemiological and causal analysis expertise to this collaboration as well as generating epigenomic data for use by colleagues at EBI.
Collaborator Contribution Bioinformatic expertise for the functional annotation of observed associations.
Impact EBI have been involved in ARIES and have more recently been closely involved in formulating large strategic funding applications. The outputs of this work are too early to report. This is a multi-disciplinary collaboration between epidemiologists and bioinformaticians.
Start Year 2013
 
Description GOYA Study Copenhagen 
Organisation Copenhagen University Hospital
Country Denmark 
Sector Hospitals 
PI Contribution We have generated epigenome-wide DNA methylation data on the GOYA cohort (a study of the offspring of extremely obese individuals) and have provided advice and analytical support in the use of these data.
Collaborator Contribution The provision of biological samples for epigenetic profiling as well as associated data for analysis. Our collaborators also facilitate the acquisition of ethical permission to use the data for new analyses.
Impact As a consequence of this collaboration GOYA is now part of the PACE study and features in various manuscripts that are currently in preparation led by my group.
Start Year 2013
 
Description GW4 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution The GW4 strategic alliance has established the GW4 Epigenetics Consortium which I instigated and brings complementary expertise from the 4 contributing Universitites together.We hosted a 2 day symposium and workshops and have subsequently secured and undertaken research activities around the use of CRISPR/Cas9 in epigenetics studies
Collaborator Contribution 2 day symposium and workshops. Epidemiology expertise.
Impact 2 day symposium and workshops. Further grant application to GW4 for research activities. This is a multi-disciplinary collaboration between epidemiologists, clinicians, experimental biologists, bioinformaticians and epigeneticists
Start Year 2014
 
Description GW4 
Organisation University of Bath
Country United Kingdom 
Sector Academic/University 
PI Contribution The GW4 strategic alliance has established the GW4 Epigenetics Consortium which I instigated and brings complementary expertise from the 4 contributing Universitites together.We hosted a 2 day symposium and workshops and have subsequently secured and undertaken research activities around the use of CRISPR/Cas9 in epigenetics studies
Collaborator Contribution 2 day symposium and workshops. Epidemiology expertise.
Impact 2 day symposium and workshops. Further grant application to GW4 for research activities. This is a multi-disciplinary collaboration between epidemiologists, clinicians, experimental biologists, bioinformaticians and epigeneticists
Start Year 2014
 
Description GW4 
Organisation University of Exeter
Country United Kingdom 
Sector Academic/University 
PI Contribution The GW4 strategic alliance has established the GW4 Epigenetics Consortium which I instigated and brings complementary expertise from the 4 contributing Universitites together.We hosted a 2 day symposium and workshops and have subsequently secured and undertaken research activities around the use of CRISPR/Cas9 in epigenetics studies
Collaborator Contribution 2 day symposium and workshops. Epidemiology expertise.
Impact 2 day symposium and workshops. Further grant application to GW4 for research activities. This is a multi-disciplinary collaboration between epidemiologists, clinicians, experimental biologists, bioinformaticians and epigeneticists
Start Year 2014
 
Description GenR-ADHD 
Organisation Erasmus University Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution joint analysis of ALSPAC and GenR epigenetic data
Collaborator Contribution joint analysis of ALSPAC and GenR epigenetic data
Impact No output yet, but expected in 2017
Start Year 2016
 
Description GoDMC: Genetics of DNA Methylation Consortium 
Organisation Austrian Academy of Sciences
Department Research Centre for Molecular Medicine
Country Austria 
Sector Academic/University 
PI Contribution We are currently leading the GoDMC consortium. The GoDMC consortium consists of five core groups (IEU, Kings College London, University of Exeter, Leiden University Medical Centre and Austrian Academy of Sciences) and we recruited 30+ cohorts to contribute to the GoDMC consortium. Matt Suderman and Josine Min have developed an R package "Efficient algorithms for analyzing DNA methylation data" (meffil) (https://github.com/perishky/meffil) which is designed to conduct quality control and normalization of large-scale methylation datasets. Meffil also conducts epigenome wide association studies (EWAS) using four different methods. In addition, Josine Min and Gibran Hemani have written a pipeline on github, which automates all analyses. Participating cohorts will download the pipeline and will follow instructions to run the pipeline.
Collaborator Contribution We have monthly calls with the core team to discuss analyses and there are weekly calls between analysts for technical issues. The core analysts are testing the pipeline on their cohorts externally.
Impact Software development: R package meffil and github pipeline for GoDMC analyses Disciplines: Genetic epidemiology, epigenetic epidemiology
Start Year 2013
 
Description GoDMC: Genetics of DNA Methylation Consortium 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution We are currently leading the GoDMC consortium. The GoDMC consortium consists of five core groups (IEU, Kings College London, University of Exeter, Leiden University Medical Centre and Austrian Academy of Sciences) and we recruited 30+ cohorts to contribute to the GoDMC consortium. Matt Suderman and Josine Min have developed an R package "Efficient algorithms for analyzing DNA methylation data" (meffil) (https://github.com/perishky/meffil) which is designed to conduct quality control and normalization of large-scale methylation datasets. Meffil also conducts epigenome wide association studies (EWAS) using four different methods. In addition, Josine Min and Gibran Hemani have written a pipeline on github, which automates all analyses. Participating cohorts will download the pipeline and will follow instructions to run the pipeline.
Collaborator Contribution We have monthly calls with the core team to discuss analyses and there are weekly calls between analysts for technical issues. The core analysts are testing the pipeline on their cohorts externally.
Impact Software development: R package meffil and github pipeline for GoDMC analyses Disciplines: Genetic epidemiology, epigenetic epidemiology
Start Year 2013
 
Description GoDMC: Genetics of DNA Methylation Consortium 
Organisation Leiden University Medical Center
Country Netherlands 
Sector Multiple 
PI Contribution We are currently leading the GoDMC consortium. The GoDMC consortium consists of five core groups (IEU, Kings College London, University of Exeter, Leiden University Medical Centre and Austrian Academy of Sciences) and we recruited 30+ cohorts to contribute to the GoDMC consortium. Matt Suderman and Josine Min have developed an R package "Efficient algorithms for analyzing DNA methylation data" (meffil) (https://github.com/perishky/meffil) which is designed to conduct quality control and normalization of large-scale methylation datasets. Meffil also conducts epigenome wide association studies (EWAS) using four different methods. In addition, Josine Min and Gibran Hemani have written a pipeline on github, which automates all analyses. Participating cohorts will download the pipeline and will follow instructions to run the pipeline.
Collaborator Contribution We have monthly calls with the core team to discuss analyses and there are weekly calls between analysts for technical issues. The core analysts are testing the pipeline on their cohorts externally.
Impact Software development: R package meffil and github pipeline for GoDMC analyses Disciplines: Genetic epidemiology, epigenetic epidemiology
Start Year 2013
 
Description GoDMC: Genetics of DNA Methylation Consortium 
Organisation University of Exeter
Department Medical School
Country United Kingdom 
Sector Academic/University 
PI Contribution We are currently leading the GoDMC consortium. The GoDMC consortium consists of five core groups (IEU, Kings College London, University of Exeter, Leiden University Medical Centre and Austrian Academy of Sciences) and we recruited 30+ cohorts to contribute to the GoDMC consortium. Matt Suderman and Josine Min have developed an R package "Efficient algorithms for analyzing DNA methylation data" (meffil) (https://github.com/perishky/meffil) which is designed to conduct quality control and normalization of large-scale methylation datasets. Meffil also conducts epigenome wide association studies (EWAS) using four different methods. In addition, Josine Min and Gibran Hemani have written a pipeline on github, which automates all analyses. Participating cohorts will download the pipeline and will follow instructions to run the pipeline.
Collaborator Contribution We have monthly calls with the core team to discuss analyses and there are weekly calls between analysts for technical issues. The core analysts are testing the pipeline on their cohorts externally.
Impact Software development: R package meffil and github pipeline for GoDMC analyses Disciplines: Genetic epidemiology, epigenetic epidemiology
Start Year 2013
 
Description Harvard School of Public Health 
Organisation Harvard University
Department Harvard T.H. Chan School of Public Health
Country United States 
Sector Academic/University 
PI Contribution Epigenetic epidemiology expertise
Collaborator Contribution Social epidemiology and social determinants of health. This collaboration, primarily with Prof Nancy Krieger, involves collaboration on biosocial epigenetics research. Prof Krieger leads a unique study on racial and economic discrimination on which we are planning epigenetic studies.
Impact Collaborators are involved in Relton CL (PI), Davey Smith G, Power C, Deary I, Davies N, Tilling K, Gaunt T, Munafo M, Windmeijer F, Visscher P, Marioni R, Ingram N, van den Berg G, Murtagh M. Epigenetics: Environment, Embodiment and Equality (E4). ESRC. £667,460. Preparations are in progress for an NIH grant submission.
Start Year 2014
 
Description IARC 
Organisation International Agency for Research on Cancer (IARC)
Country France 
Sector Public 
PI Contribution This long-standing collaboration (consolidated by a short sabbatical in 2008) led to a large scale NIH funded biomarker study which is ongoing. More recently, a CRUK programme in integrative cancer epidemiology has been awarded on which I am Co-PI. I bring programme leadership and epigenetic epidemiology and causal analysis expertise.
Collaborator Contribution Genetic epidemiology and access to large multi-national consortia.
Impact P Brennan, M Johansson, CL Relton, PM Ueland, P Vineis et al. One carbon metabolism biomarkers and lung cancer risk. Sep 2011-Aug 2016 NIH/NCI R01 [$5,060,000] Co-I Martin RM (Co-PI), Relton CL (Co-PI) et al. Reducing the burden of cancer: Causal risk factors, mechanistic targets and predictive biomarkers. £4.15M. CRUK Programme. Jun 2015 - May 2020. Johansson M, Fanidi A, Muller D, Bassett J, Midttun Ø, Vollset SE, Travis R, Palli D, Mattiello A, Sieri S, Trichopoulou A, Lagiou P, Trichopoulos D, Ljungberg B, Hallmans G, Weiderpass E, Skeie G, González C, Dorronsoro M, Peeters P, Bueno-de-Mesquita HB, Ros M, Boutron-Ruault MC, Fagherazzi G, Clavel-Chapelon F, Sánchez MJ, Barricarte Gurea A, Navarro C, Quirós JR, Overvad K, Tjønneland A, Aleksandrova K, Vineis P, Gunter M, Giles G, Relton C, Riboli E, Boeing H, Ueland PM, Severi G, Brennan P. Circulating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survival. J Natl Cancer Inst 2014;106(12):pii. PMID: 25376861 Fanidi A, Relton CL, Ueland PM, Midtun Ø, Vollset SE, Travis RC, Trichopoulou A, Lagiou P, Trichopoulos D, Bueno-de-Mesquita HB, Ros M, Boeing H, Tumino R, Panico S, Palli D, Sieri S, Vineis P, Sánchez MJ, Huerta JM, Barricarte Gurrea A, Luján-Barroso L, Quirós JR, Tjønneland A, Halkjær J, Boutron-Ruault MC, Clavel-Chapelon F, Cadeau C, Weiderpass E, Johansson M, Riboli E, Brennan P, Johansson M. A prospective study of one-carbon metabolism biomarkers and cancer of the head, neck and oesophagus. Int J Cancer 2014;136(4):915-27. PMID: 24975698 Fasanelli F, Baglietto L, Ponzi E, Guida F, Campanella G, Johansson M, Grankvist K, Johansson M, Assumma MB, Naccarati A, Chadeau-Hyam M, Ala U, Faltus C, Kaaks R, Risch A, De Stavola B, Hodge A, Giles GG, Southey MC, Relton CL, Haycock PC, Lund E, Polidoro S, Sandanger TM, Severi G, Vineis P. Hypomethylation of smoking-related gene is associated with future lung cancer in four prospective cohorts. Nat Commun 2015 Dec 15;6:10192. doi: 10.1038/ncomms10192. PMID: 26667048 Further manuscripts are under review.
Start Year 2007
 
Description KCL - Epigenetics 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution We bring epidemiological expertise and expertise in causal analysis methodology to a series of collaborations. We have collaborated on joint research proposals which have been successful.
Collaborator Contribution Our collaborators bring the following expertise; Dr Helen Fisher: Social Science and Psychiatry Dr Ted Barker: Conduct problems Dr Jordana Bell; Twin studies
Impact Dr Fisher was awarded a MQ Fellowship on which I act as a sponsor. We are Co-Investigators on a recently awarded ESRC grant; Howe L, Relton CL (Co-I), Davey Smith G, Gaunt T, Suderman M, Simpkin A, Davies N, Shihab H, Marioni R, Hardy R, Wong C, Fisher H, John R, Jerrim J, Deary I, Mill J. Interpreting epigenetic signatures in studies of early life adversity (InterSTELA) ESRC. £195,513. Drs Bell and Fisher is a collaborator on a further ESRC grant of which I am PI; Relton CL (PI), Davey Smith G, Power C, Deary I, Davies N, Tilling K, Gaunt T, Munafo M, Windmeijer F, Visscher P, Marioni R, Ingram N, van den Berg G, Murtagh M. Epigenetics: Environment, Embodiment and Equality (E4). ESRC. £667,460. We have collaborated with Dr Barker on a NIH-funded project; E Barker, J Mill, G Davey Smith, B Maughan, CL Relton. Epigenetic pathways to conduct problem trajectories: the role of prenatal and postnatal environmental risk exposures. Jan 2012-Dec 2016 NIH/NICHD [£1,100,000] Co-I. With the following outputs; Cecil CAM, Lysenko LJ, Jaffee SR, Pingault J-B, Smith RG, Relton CL, Woodward G, McArdle W, Mill J, Barker ED. Environmental risk, oxytocin receptor gene (OXTR) methylation and youth callous-unemotional traits: A 13-year longitudinal study. Mol Psychiatry 2014;19(10):1071-7. PMID: 25199917 Rijlaarsdam J, Pappa I, Walton E, Bakermans-Kranenburg MJ, Mileva-Seitz VR, Rippe RC, Roza SJ, Jaddoe VW, Verhulst FC, Felix JF, Cecil CA, Relton CL, Gaunt TR, McArdle W, Mill J, Barker ED, Tiemeier H, van Ijzendoom MH. An epigenome-wide association meta-analysis of prenatal maternal stress in neonates: A model approach for replication. Epigenetics 2016. In Press. Further papers are under review. Dr Bell is a co-PI of the Genetics of DNA Methylation Consortium (GoDMC).
Start Year 2013
 
Description Leiden University Medical Centre 
Organisation Leiden University Medical Center
Country Netherlands 
Sector Multiple 
PI Contribution We have collaborated on the ARIES study which included the profiling of DNA methylation in autopsy samples provided by Dr Bas Heijman's group at LUMC in our Bristol labs. We have cleaned and QC'd the data and contributed to data analysis. We also work closely with this group in leading the Genetics of DNA Methylation Consortium (GoDMC).
Collaborator Contribution Our collaborators provided autopsy biological samples and associated data. They have led the data analysis and preparation of findings for publication.
Impact A Data Resource Profile has been published; Relton CL, Gaunt T, McArdle W, Ho K, Duggirala A, Shihab H, Woodward G, Lyttleton O, Evans DM, Reik W, Paul YL, Ficz G, Ozanne SE, Wipat A, Flanagan K, Lister A, Heijmans BT, Ring SM, Davey Smith G. Data Resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES). Int J Epidemiol 2015;44(4):1181-90. PMID: 25991711 A further publication describing methylation profiles in different tissues is in preparation.
Start Year 2013
 
Description Longitudinal_epi_GenR 
Organisation Erasmus University Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution joint analysis of ALSPAC and GenR epigenetic data
Collaborator Contribution joint analysis of ALSPAC and GenR epigenetic data
Impact No output yet, but expected in 2017
Start Year 2016
 
Description MRC Lifecourse Epidemiology Unit - Southampton 
Organisation University of Southampton
Department MRC Lifecourse Epidemiology Unit
Country United Kingdom 
Sector Public 
PI Contribution I chair the Steering Group of a MRC-Newton Fund UK-India & Africa Project; Epigenetic mechanisms linking maternal pre-conceptional micronutrient supplementation with offspring health in India and The Gambia
Collaborator Contribution Opportunity to contribute to a multi-national epigenetics project and share our knowledge and expertise in epigenetic epidemiology and causal analysis methods
Impact First Steering Group meeting, held in Hyderabad Feb 2016.
Start Year 2013
 
Description MRC The Gambia 
Organisation Medical Research Council (MRC)
Department MRC Unit, The Gambia
Country Gambia 
Sector Public 
PI Contribution Collaboration in epigenetics research. Co-investigator on recently funded award to establish a W African Bioresource in nutritional genetics and epigenetics.
Collaborator Contribution Myself and members of my team have committed to helping our colleagues at the MRC Gambia Unit establish a bioresource to support molecular epidemiology research in the future. This will involve researcher exchanges,workshops and training in Bristol and the provision of ongoing support and capacity building in The Gambia.
Impact No outputs to report as yet
Start Year 2018
 
Description MRC Unit for LIfelong Health and Ageing 
Organisation University College London
Department MRC Unit for Lifelong Health and Ageing
Country United Kingdom 
Sector Public 
PI Contribution We bring epigenetics expertise to this collaboration. The NSHD (MRC 1946 Study) complements the Bristol-based ALSPAC study. I am a member of the NSHD Biosample Access Committee
Collaborator Contribution We collaborate on a variety of studies including epigenetics of the menopausal transition and the role of biosocial factors in epigenetic variation. The NSHD is a collaborating cohort on a recently awarded ESRC project grant.
Impact Relton CL (PI), Davey Smith G, Power C, Deary I, Davies N, Tilling K, Gaunt T, Munafo M, Windmeijer F, Visscher P, Marioni R, Ingram N, van den Berg G, Murtagh M. Epigenetics: Environment, Embodiment and Equality (E4). ESRC. £667,460. Howe L, Relton CL (Co-I), Davey Smith G, Gaunt T, Suderman M, Simpkin A, Davies N, Shihab H, Marioni R, Hardy R, Wong C, Fisher H, John R, Jerrim J, Deary I, Mill J. Interpreting epigenetic signatures in studies of early life adversity (InterSTELA) ESRC. £195,513.
Start Year 2013
 
Description Norwegian Institute of Public Health 
Organisation Norwegian Institute of Public Health
Country Norway 
Sector Academic/University 
PI Contribution We bring epigenetic epidemiology expertise to this collaboration.
Collaborator Contribution Access to a very large birth cohort as well as epidemiological and clincial expertise.
Impact Inclusion in the PACE consortium. Training and exchange visits. Preparation of joint grant applications. Joint research publications e.g. "25-hydroxyvitamin D in pregnancy and genome wide cord blood DNA methylation in two pregnancy cohorts (MoBa and ALSPAC) The Journal of Steroid Biochemistry and Molecular Biology Suderman M, Stene LC, Bohlin J, Page CM, Holvik K, Parr CL, Magnus MC, Håberg Siri E, Joubert BR, Wu MC, London SJ, Relton C, Nystad W
Start Year 2013
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Center for Environmental Research and Children's Health
Department The CHAMACOS Study
Country United States 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Columbia Center for Children's Environmental Health
Country United States 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation European Association for Research on Learning and Instruction (EARLI)
Country Belgium 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation European Huntington's Disease Network (Euro-HD)
Country Germany 
Sector Charity/Non Profit 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Federal Ministry for the Environment, Nature Conservation and Nuclear Safety (BMU)
Department International Climate Initiative (ICI)
Country Germany 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Finnish Birth Cohort
Country Finland 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation GECKO Drenthe Birth Cohort
Country Netherlands 
Sector Hospitals 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation GenExp
Country United Kingdom 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation GenR
Country United States 
Sector Charity/Non Profit 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Glyndwr University
Country United Kingdom 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Government of Canada
Department Aboriginal Affairs and Northern Development
Country Canada 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation ITS United Kingdom
Country United Kingdom 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Inmarsat
Country United Kingdom 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation MTT Ltd Machine Tools Technologies
Country United Kingdom 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation National Heart, Lung, and Blood Institute (NHLBI)
Country United States 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation National Institute of Environmental Health Sciences
Department Norway Facial Clefts Study (NCL)
Country United States 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation National Institute of Standards & Technology (NIST)
Country United States 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation New Hampshire Birth Cohort Study
Country United States 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation PRISMA ONG
Country Peru 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Progressive Energy Ltd
Country United Kingdom 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Project Viva
Country United States 
Sector Charity/Non Profit 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Rutherford Appleton Laboratory
Department Space Science and Technology Department
Country United Kingdom 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation University of Bristol
Department Avon Longitudinal Study of Parents and Children (ALSPAC)
Country United Kingdom 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation University of Cambridge
Department PomBase
Country United Kingdom 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation University of Western Australia
Department Raine Medical Research Foundation
Country Australia 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation VCE Mobile & Personal Comm Ltd
Country United Kingdom 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Public Health Foundation India 
Organisation Public Health Foundation of India
Country India 
Sector Public 
PI Contribution I supervise a PHFI Postdoctoral Fellow, Dr Gagandeep Kaur Walia. I regularly host this fellow in my research group and provide ad hoc research support and advice to her.
Collaborator Contribution Cultural diversity and the opportunity to collaborate with Indian cohort studies.
Impact Kaur Walia G. Public Health Foundation of India-UK Joint Fellowship. Jul 2015-Jun2017. Supervisor.
Start Year 2013
 
Description Sanofi Aventis 
Organisation Sanofi
Department Aventis
Country France 
Sector Private 
PI Contribution Epigenetics expertise and functional annotation of target loci identified by the collaborators
Collaborator Contribution Direction in terms of target prioritization as well as financial support for a postdoctoral assistant.
Impact An Annotation pipeline has been developed to provide information on potential targets.
Start Year 2015
 
Description UFPel 
Organisation Federal University of Pelotas (UFPel)
Country Brazil 
Sector Academic/University 
PI Contribution Epigenetic epidemiology expertise. Training provision (hosting of visiting researchers and delivery of training in Brazil) Contribution to co-supervision of a PhD student
Collaborator Contribution Access to unique Brazilian birth cohorts. Maternal and perinatal epidemiology
Impact Relton CL, Hartwig FP Davey Smith G. From stem cells to the law courts: DNA methylation, the forensic epigenome and the possibility of a biosocial archive. Int J Epidemiol 2015 44 (4): 1083-1093. doi: 10.1093/ije/dyv198 Genomics, Epigenomics and Causal Inference in Population Health, Federal University of Pelotas, Brazil, March 2015
Start Year 2013
 
Description University of Exeter Medical School 
Organisation University of Exeter
Department Medical School
Country United Kingdom 
Sector Academic/University 
PI Contribution My team collaborates with genetic epidemiologists and epigeneticists at this institution. I am a collaborator on the Wellcome Trust Sir Henry Dale Felowship of Dr Rachel Freathy. I also bring epidemiological expertise to our collaboration with Prof Jonathan Mill, with whom we have obtained joint funding.
Collaborator Contribution Dr Freathy undertakes large scale genetic epidemiology and utilises samples from our studies. Prof Mill brings epigenetic expertise as well as tissue specific epigenetic studies. We collaborate with Prof Mills in the leadership of the genetics of DNA methylation Consortium (GoDMC).
Impact GW4 Initiator grant to establish a GW Epigenetics Consortium GW4 Accelerator grant (CRISPR/Cas) to pilot gene editing on epigenetic loci. Prof Mill is a co-PI on the Genetics of DNA Methylation Consortium
Start Year 2013
 
Description University of Queensland 
Organisation University of Queensland
Country Australia 
Sector Academic/University 
PI Contribution Epigenetic epidemiology and causal analysis expertise
Collaborator Contribution Quantitative genetics expertise
Impact Evans D (PI), Relton C, Davey Smith G Powell J. Novel ways of utilizing genome-wide DNA methylation data from peripheral blood samples in genetic epidemiology. ~£400k. NHMRC. Jan 2015 - Dec 2017. Involvement in recently awarded project: Relton CL (PI), Davey Smith G, Power C, Deary I, Davies N, Tilling K, Gaunt T, Munafo M, Windmeijer F, Visscher P, Marioni R, Ingram N, van den Berg G, Murtagh M. Epigenetics: Environment, Embodiment and Equality (E4). ESRC. £667,460.
Start Year 2013
 
Title EWAS Catalog 
Description This webtool/application has curated all published epigenome-wide association studies (EWAS) (using the Illumina BeadChip platform) and incorporated them in to a searchable data base. This allows the user to locate any variable methylation probes they may be interested in in a similar way to the GWAS catalog for genetic variants. It provides a centralised repository and search tool for any investigator interested in EWAS. 
Type Of Technology Webtool/Application 
Year Produced 2018 
Open Source License? Yes  
Impact The web application has just been released. It should have considerable impact across the research community as a browsing facility for all documented EWAS that appear in the published literature. 
URL http://www.ewascatalog.org
 
Description Co-coordinator and lecturer on Swiss Epidemiology Winter School in 2019 - R.Richmond 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Rebecca Richmond presented a lecture to 20 Epidemiology students and researchers at the Swiss Epidemiology Winter School in 2019, this sparked discussions for future collaborations.
Year(s) Of Engagement Activity 2019
 
Description Citizen Science Project - R.Richmond 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Rebecca Richmond has been involved in a Citizen Science project taking place as part of the SPHERE initiative which has involved engaging and working with members of the project as part of a participant-led research project around sleep.
Year(s) Of Engagement Activity 2018
 
Description Education in our genes 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This one day workshop was aimed at both social and biomedical scientists to present current developments around the application of genetic and epigenetic data in relation the educational attainment and related characteristics
Year(s) Of Engagement Activity 2017
 
Description Epigenetic Clock Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A one day workshop was held to present and discuss approaches to research using the epigenetic clock as a biomarker of biological age.
Year(s) Of Engagement Activity 2017
 
Description Fun Palaces event planning - Rebecca Richmond 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Rebecca Richmond (ICEP Researcher) helped to organise a public engagement event relating to her e-cigarette study which was at Fun Palaces in Bristol in October 2017. Fun Palaces initiative is where community organisations lead events to connect public members with scientific research through creative interests or hobbies and expertise that may sit within those communities. The event allowed knowledge exchange between researchers and the public, informing about the demographic of e-cigarette use.
Year(s) Of Engagement Activity 2017
 
Description Greenman - R.Richmond 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Rebecca Richmond helped to organize and implement several public engagement activities in the "Einstein's Garden" of the Green Man Festival in 2018. More than 500 people attended.
Year(s) Of Engagement Activity 2018
 
Description IGES conference - J.Staley 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact James Staley presented a conference poster to 250 people at the IGES Conference in San Diego, on the 18th October 2018. The poster/presentation is entitled: Longitudinal strategies for identifying genetic associations with epigenetic changes over time
Year(s) Of Engagement Activity 2018
 
Description Inaugural Researchers' Summit for the new India-UK Cancer Research Initiative - C Relton 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Caroline Relton (ICEP PI) was invited to attend the Inaugural Researchers' Summit for the new India-UK Cancer Research Initiative, a joint venture between Cancer Research UK and the Indian Government's Department of Biotechnology (DBT). This initiative seeks to establish new bilateral research alliances to undertake impactful research and develop innovative approaches to improving cancer outcomes. The Summit took place in New Delhi, India in November 2018 and brought together leading researchers, clinicians and technologists to identify the core research challenges under the broad theme of affordable approaches to cancer.
Year(s) Of Engagement Activity 2018
 
Description Molecular Epidemiology Group Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Annual scientific meeting of a multi-disciplinary academic group of international researchers
Year(s) Of Engagement Activity 2019
 
Description Presentation at Nutrition Symposium, Erasmus - C Relton 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Caroline Relton was invited to present at Nutrition Symposium, Erasmus Medical Center in June 2018. Prof Relton presented: Causal analysis in epigenetic epidemiology. The talk prompted the following exchange of letters: http://advances.sciencemag.org/content/4/1/eaao4364/tab-e-letters. The talk also raised the profile of Prof Relton and her research.
Year(s) Of Engagement Activity 2018
URL http://advances.sciencemag.org/content/4/1/eaao4364/tab-e-letters
 
Description Statistics in Epigenetics Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A one day workshop was held to describe and discuss recent key statistical advances for analysing DNA methylation data funded by an MRC grant. A keynote lecture was also given on the 'Estimation of a significance threshold for epigenome-wide association studies'. Over 60 post-grad students, fellow researchers, and health professionals attended this free workshop.
Year(s) Of Engagement Activity 2018
URL https://www.eventbrite.co.uk/e/epigenetics-statistics-workshop-tickets-49889050493
 
Description Visit to Barshi, India - C Relton 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Professors Caroline Relton and George Davey Smith went to Barshi, India in May 2018. They visited the India Study for Health of Adults (Barshi Cohort Study) in action and the TATA Memorial Centre. Their trip included presenting to villages who were cohort participants and visiting the field site of the Barshi cohort. Future collaborations between Bristol and the TATA team were discussed.
Year(s) Of Engagement Activity 2018
 
Description Wellcome Training Workshop at OUCRU - C Relton 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Prof Caroline Relton (ICEP PI) visited OUCRU (Oxford University Clinical Research Unit) in Ho Chi Minh City and Hanoi, Vietnam for a week in April 2018. The workshops were set up by the Wellcome Trust, where Prof Relton delivered training in group leadership, the process of peer review, grant writing and career development to Wellcome-funded researchers of all stages based there.
Year(s) Of Engagement Activity 2018