Epigenetic Epidemiology

Lead Research Organisation: University of Bristol

Abstract

This programme aims to gain a better understanding of the determinants and consequences of epigenetic variation through the use of epidemiological approaches. We will extend our knowledge of the relationship between common genetic variation and DNA methylation across the genome through large scale GWAS analysis. The identification of genetic variants that tag methylation variation will enhance our ability to conduct Mendelian randomization to strengthen causal inference. We will develop our use of DNA methylation as a biomarker of disease prediction and prognosis as well as an index of exposure to disease risk factors. Lastly, we will combine these elements of the programme and other methodological advances in epigenetic epidemiology to address a variety of disease specific research questions.

Technical Summary

Background: To maximally exploit the rapid pace of change, including the accrual of large-scale data, in the field of epigenetic epidemiology, we will develop innovative methods for the robust scientific interrogation of population-based epigenetic data and apply them to research questions of scientific and medical importance, structured around four domains:
Aim 1: We will explore the genetic architecture of epigenetic traits and use this information to understand the role that DNA methylation variation plays in health and disease.
Aim 2: We will develop and make readily accessible the causal analysis methods and tools and apply Mendelian randomization (MR) to epigenetic questions.
Aim 3: We will use DNA methylation as an index of past exposures to improve our prediction of disease risk and prognosis.
Aim 4: From neurodevelopment to cancer, there are a multitude of settings in which we can apply epigenetic epidemiology to understand disease mechanisms and predict disease.
Methods: We will utilize multiple data sources; from in-house studies, via collaborations and consortia, and through publicly accessible repositories. Our primary focus will be on the analysis of DNA methylation, as this continues to be the most readily available source of epigenetic data in population-based studies. However, we will integrate these data with newly generated and publicly available epigenomic and transcriptomic data, tissue-specific data and histone modification data.
A wide range of methods will be applied. These include mQTL analysis, functional annotation and machine learning approaches, such as penalized regression, support vector machines, and neural networks. We will test for mediation using MR and apply our prediction methods in disease relevant datasets.
Translation: The output arising from this programme will be used to develop biomarkers of disease risk and disease prognosis. It will also shed light on the genetic architecture of DNA methylation and the causal role this molecular phenotype plays in development and disease, which will in turn inform future interventions.

Organisations

Publications

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Langdon RJ (2019) A Phenome-Wide Mendelian Randomization Study of Pancreatic Cancer Using Summary Genetic Data. in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

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Staley JR (2021) A robust mean and variance test with application to high-dimensional phenotypes. in European journal of epidemiology

 
Description 1001 Critical Days consultation
Geographic Reach National 
Policy Influence Type Participation in a national consultation
URL https://epoch.blogs.bristol.ac.uk/2020/02/04/the-1001-critical-days-movement/
 
Description COVID response
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
Impact I have contributed to the Bristol City Council Health Protection Advisory Group and chair the University of Bristol COVID-19 Scientific Advisory Group. Both are concerned with synthesis of evidence to support COVID response in the University, city and region. This has included a twice monthly institutional risk assessment involving city of Bristol Public Health colleagues, UK HSA and the University management.
 
Description Co-director of the MSc in Reproduction and Development
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact Gemma Sharp is the co-director of the University of Bristol's highly successful MSc in Reproduction and Development. Students include practicing midwifes, junior doctors, researchers and embryologists. The course equips them with the necessary skills to improve their practice and critically appraise, design and conduct relevant research.
URL http://www.bristol.ac.uk/medical-school/study/postgraduate/reproduction-development/
 
Description DHSC consultation on women's health
Geographic Reach National 
Policy Influence Type Participation in a national consultation
URL https://www.gov.uk/government/consultations/womens-health-strategy-call-for-evidence
 
Description Genetic and Epigenetic Epidemiology (EEPE) course
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact Gemma Sharp and Rebecca Richmond (along with David Evans and Gib Hemani) co-developed and delivered a one week course on genetic and epigenetic epidemiology in Florence. Participants ranged from masters to professorial level. The course was very well-received and participants reported feeling confident that they had achieved the intended learning outcomes. Several are now conducting their own genetic/epigenetic studies.
URL https://eepe.org/courses/
 
Description Lectures at LSHTM
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact Gemma Sharp was invited to give two lectures to masters students at the London School of Hygiene and Tropical Medicine: "Minimising bias and confounding in observational epidemiology" and "Mendelian Randomization". These will take place on March 17th 2020. The lectures are intended to introduce students to these important areas and methods in observational epidemiology and equip them with the skills to critically appraise, design and conduct high quality epidemiological research.
 
Description MSc in Epidemiology - unit lead of 'Molecular Epidemiology for Noncommunicable Disease'
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact Gemma Sharp co-developed from scratch and now co-delivers a unit on Molecular Epidemiology as part of the University of Bristol's MSc in Epidemiology. The unit introduces masters students to molecular (genetic and epigenetic) epidemiology and equips them with the skills to critically appraise, design and conduct high quality epidemiological research.
URL https://www.bris.ac.uk/unit-programme-catalogue/UnitDetails.jsa;jsessionid=2BBAB6E8979AB5B406936FBF3...
 
Description WRISK project expert panel - Gemma Sharp
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
URL https://threadreaderapp.com/thread/1220645863577485312.html
 
Description Workshop on harmonisation of data in multicohort studies
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact Gemma Sharp gave a talk as part of a half-day course on data harmonization in observational studies at the DOHaD 2019 world congress in Melbourne. Participants ranged from masters to professorial level. The course was very well-received and participants reported feeling confident that they had achieved the intended learning outcomes. Several are now conducting their own multi cohort studies.
URL http://www.cvent.com/events/2019-dohad-international/custom-132-828d23c3caf043c0ae6449de8d7bfbc3.asp...
 
Description Workshop on triangulation
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact Gemma Sharp co-developed and delivered a half-day course on triangulation in observational studies at the DOHaD 2019 world congress in Melbourne. Participants ranged from masters to professorial level. The course was very well-received and participants reported feeling confident that they had achieved the intended learning outcomes. Several are now conducting their own triangulation studies.
URL http://www.cvent.com/events/2019-dohad-international/custom-132-828d23c3caf043c0ae6449de8d7bfbc3.asp...
 
Description 4-year PhD Programme in Molecular Genetic and Lifecourse Epidemiology
Amount £5,153,172 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2019 
End 08/2025
 
Description COVID-19 Mapping and Mitigation in Schools (CoMMinS)
Amount £2,817,666 (GBP)
Funding ID MR/V028545/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 08/2020 
End 08/2021
 
Description Creating a West African BioResource for Nutritional Genetics and Epigenetics (C Relton)
Amount £186,171 (GBP)
Funding ID MC_PC_MR/R020183/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2018 
End 12/2018
 
Description DNA methylation & adversity: pathways from exposures to health inequities
Amount $2,352,682 (USD)
Funding ID 1R01MD014304 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 08/2021 
End 03/2023
 
Description De Pass Vice Chancellor's Fellowship - Rebecca Richmond
Amount £260,000 (GBP)
Organisation University of Bristol 
Sector Academic/University
Country United Kingdom
Start 09/2018 
End 10/2022
 
Description Does epigenetic methylation explain the gender-switch in adolescent asthma?
Amount $3,137,380 (USD)
Organisation National Institutes of Health Clinical Center 
Sector Hospitals
Country United States
Start 01/2016 
End 01/2021
 
Description EPIC DIVE - Early PancreatIc Cancer Diagnosis In Vivo Evaluation
Amount £228,000 (GBP)
Funding ID EDDISA-Jan22\100004 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2022 
End 12/2023
 
Description ERA-HDHL - Early life programming of childhood health: a nutritional and epigenetic investigation of adiposity and bone, cardiometabolic, neurodevelopmental and respiratory health.
Amount £124,600 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 03/2017 
End 12/2019
 
Description FDS RCSEng - British Association of Oral Surgeons grant
Amount £10,000 (GBP)
Organisation British Association of Oral and Maxillofacial Surgeons 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2021 
End 06/2022
 
Description GW4 Generator Award
Amount £14,800 (GBP)
Organisation GW4 
Sector Academic/University
Country United Kingdom
Start 05/2021 
End 11/2021
 
Description GW4 Neurodevelopmental neurodiversity network
Amount £18,200 (GBP)
Organisation GW4 
Sector Academic/University
Country United Kingdom
Start 03/2020 
End 03/2024
 
Description HDR UK RCUK Innovation/Rutherford Fellowships - Two fellowships (C Relton)
Amount £614,457 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 02/2018 
End 01/2021
 
Description NIH - Childhood adversity, DNA methylation and risk for depression: A longitudinal study of sensitive periods in development.
Amount $1,623,764 (USD)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 09/2017 
End 10/2019
 
Description Religious belief, health, and disease: a family perspective II. The follow-up and analyses
Amount £8,000,000 (GBP)
Funding ID 61917 
Organisation The John Templeton Foundation 
Sector Academic/University
Country United States
Start 08/2021 
End 08/2026
 
Description Siddhartha Kar UKRI Future Leader Fellowship
Amount £818,050 (GBP)
Funding ID MR/T043202/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2020 
End 09/2024
 
Description Study of emerging adulthood and cardiometabolic health in ALSPAC: the influence of growth and other exposures (SEA CHANGE)
Amount £999,049 (GBP)
Funding ID CS/15/6/31468 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2015 
End 07/2020
 
Description WCRF Investigator Initiated Grant
Amount £264,000 (GBP)
Organisation World Cancer Research Fund 
Sector Charity/Non Profit
Country Global
Start 01/2021 
End 12/2023
 
Title A web application for exploring tissue specific consequences of genetic variation 
Description This web application can be used to investigate associations between genome-wide gene expression and 395 complex traits by applying Mendelian randomization and genetic colocalization1. Analyses have been undertaken using gene expression derived from whole blood made available by the eQTLGen consortium2 (n=31,684), as well as 48 different tissue types from the GTEx project3. Findings from this web application can help uncover associations yet to be detected by genome-wide association studies and also investigate tissue-specific effects between gene expression and complex traits. 
Type Of Material Improvements to research infrastructure 
Year Produced 2019 
Provided To Others? Yes  
Impact The app has seen widespread use by the research community including non-academic partners. 
URL http://mrcieu.mrsoftware.org/molecular_MR_atlas
 
Title Analysis package for identifying differentially methylation regions 
Description Statistical power in epigenome-wide association studies (EWAS) tends to be low due to the cost of generating genome-wide DNA methylation profiles. dmrff increases the power of EWAS by testing associations with DNA methylation measurements spread across regions rather than being limited to individual genomic loci. 
Type Of Material Improvements to research infrastructure 
Year Produced 2019 
Provided To Others? Yes  
Impact Widespread adoption as an analytical tool by the research community. 
URL https://github.com/perishky/dmrff
 
Title GARFIELD - J.Min 
Description Josine Min has developed a novel approach that leverages genome-wide association studies' findings with regulatory or functional annotations to classify features relevant to a phenotype of interest. GARFIELD classifies disease-relevant genomic features through integration of functional annotations with association signals 
Type Of Material Improvements to research infrastructure 
Year Produced 2019 
Provided To Others? Yes  
Impact This tool has been cited in at least 21 publications. 
URL https://www.ebi.ac.uk/birney-srv/GARFIELD/
 
Title Meffil - J.Min 
Description Josine Min and other researchers have developed a new tool for performing quality control and preprocessing large sets of DNA methylation profiles used in epidemiological studies. Previous tools were unable to process such large datasets without requiring high-end computational resources. Our tool may also be used to improve statistical power in meta-analyses. 
Type Of Material Improvements to research infrastructure 
Year Produced 2018 
Provided To Others? Yes  
Impact This package has been used to analyse 36 datasets from the GoDMC consortium. It has been cited by 20 publications. 
URL https://github.com/perishky/meffil#meffil
 
Title EWAS Catalog 
Description A database of epigenome-wide association studies with seacrh tool 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
Impact None as yet 
URL http://www.ewascatalog.org
 
Title EWAS Catalog 
Description A database providing summary statistics from both published and unpublished epigenome-wide association studies. The database can be queried online or programmatically using an R package. 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
Impact None yet 
URL http://ewascatalog.org/
 
Title EWAS Catalog 
Description A database providing summary statistics from both published and unpublished epigenome-wide association studies. The database can be queried online or programmatically using an R package. 
Type Of Material Database/Collection of data 
Year Produced 2022 
Provided To Others? Yes  
Impact None yet 
URL http://ewascatalog.org/
 
Title Genetics of DNA methylation Consortium (GoDMC) - Josine Min 
Description As part of the GoDMC (Genetics of DNA methylation Consortium) we have generated a database which contains all discovered mQTL associations. It also has a dalliance genome browser to explore regional features of the association. 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? No  
Impact We have developed a github pipeline for the GoDMC consortium. So far, 36 different groups have processed and analysed their data and uploaded the results to our sftp server.We have since made the database publicly available following the upload of the main study manuscript to a pre-print server. The resource has seen widespread use by the research community. http://mqtldb.godmc.org.uk 
 
Title Identification of differentially methylated regions 
Description This software tool improves on previous work by properly controlling false positive rates, providing support for meta-analysis and increasing statistical power 
Type Of Material Data analysis technique 
Year Produced 2019 
Provided To Others? Yes  
Impact None as yet 
 
Title Paternal BMI meta-EWAS results 
Description This project explores associations between paternal body mass index around the time of conception and offspring DNA methylation in cord blood at birth and peripheral whole blood at childhood. Independent cohorts carried out epigenome-wise association studies (EWAS) according to a pre-specified analysis plan. The summary statistics from these EWAS were then meta-analysed. This dataset provides the full summary statistics for the project. 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
Impact A paper describing this study has been published and the data has been uploaded to the EWAS catalog for further use and dissemination by other groups. 
URL https://dataverse.harvard.edu/dataverse/pace_paternal_bmi_methylation
 
Description 4M consortium 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Gemma Sharp established the Menarche, Menstruation, Menopause and Mental health (4M) consortium using funding from the GW4 Alliance (generator award: £14800). The consortium brings together researchers from different disciplines and institutions, with a shared interest in the intersection of menstrual and mental health. This includes researchers interested in using molecular epidemiological approaches to conduct research in this area.
Collaborator Contribution The 4M consortium includes partners from Bath, Cardiff and Exeter University, as well as external stakeholders from charities, patient groups, the NHS, government departments, and the United Nations Population Fund (UNFPA).
Impact We have run several workshops, including a three day in-person grant writing retreat. We have developed and submitted four grant applications for further funding.
Start Year 2021
 
Description 4M consortium 
Organisation GW4
Country United Kingdom 
Sector Academic/University 
PI Contribution Gemma Sharp established the Menarche, Menstruation, Menopause and Mental health (4M) consortium using funding from the GW4 Alliance (generator award: £14800). The consortium brings together researchers from different disciplines and institutions, with a shared interest in the intersection of menstrual and mental health. This includes researchers interested in using molecular epidemiological approaches to conduct research in this area.
Collaborator Contribution The 4M consortium includes partners from Bath, Cardiff and Exeter University, as well as external stakeholders from charities, patient groups, the NHS, government departments, and the United Nations Population Fund (UNFPA).
Impact We have run several workshops, including a three day in-person grant writing retreat. We have developed and submitted four grant applications for further funding.
Start Year 2021
 
Description 4M consortium 
Organisation University of Bath
Country United Kingdom 
Sector Academic/University 
PI Contribution Gemma Sharp established the Menarche, Menstruation, Menopause and Mental health (4M) consortium using funding from the GW4 Alliance (generator award: £14800). The consortium brings together researchers from different disciplines and institutions, with a shared interest in the intersection of menstrual and mental health. This includes researchers interested in using molecular epidemiological approaches to conduct research in this area.
Collaborator Contribution The 4M consortium includes partners from Bath, Cardiff and Exeter University, as well as external stakeholders from charities, patient groups, the NHS, government departments, and the United Nations Population Fund (UNFPA).
Impact We have run several workshops, including a three day in-person grant writing retreat. We have developed and submitted four grant applications for further funding.
Start Year 2021
 
Description 4M consortium 
Organisation University of Exeter
Country United Kingdom 
Sector Academic/University 
PI Contribution Gemma Sharp established the Menarche, Menstruation, Menopause and Mental health (4M) consortium using funding from the GW4 Alliance (generator award: £14800). The consortium brings together researchers from different disciplines and institutions, with a shared interest in the intersection of menstrual and mental health. This includes researchers interested in using molecular epidemiological approaches to conduct research in this area.
Collaborator Contribution The 4M consortium includes partners from Bath, Cardiff and Exeter University, as well as external stakeholders from charities, patient groups, the NHS, government departments, and the United Nations Population Fund (UNFPA).
Impact We have run several workshops, including a three day in-person grant writing retreat. We have developed and submitted four grant applications for further funding.
Start Year 2021
 
Description ALPHABET 
Organisation University College Dublin
Department School of Public Health, Physiotherapy and Population Science
Country Ireland 
Sector Academic/University 
PI Contribution I am a co-investigator on a ERA-HDHL (BBSRC) collaborative research project on the influence of early life nutrition on offspring health led by UCD. Our contribution includes collating multi-centre epigenetic data, running epigenome-wide association studies, meta-analyses and causal analysis methods.
Collaborator Contribution The partners in this collaboration contribute data from various large birth cohort studies and expertise in nutrition and other clinical disciplines
Impact Aubert A, Forhan A, de Lauzon-Guillain B, Chen LW, Polanska K, Hanke W, Mensink-Bout SM, Duijts L, Suderman M, Relton CL, Crozier SR, Harvey NC, Cooper C, McAuliffe FM, Kelleher CC, Philips CM, Heude B, Bernard JY. Deriving the Dietary Approaches to stop Hypertension (DASH) score in women from seven pregnancy cohorts from the European ALPHABET consortium. Nutrients. 2019 Nov 8;11(11). pii: E2706. doi: 10.3390/nu11112706. PMID:31717283. Chen LW, Aubert AM, Shivappa N, Bernard JY, Mensink-Bout SM, Geraghty AA, Mehegan J, Suderman M, Polanska K, Hanke W, Trafalska E, Relton CL, Crozier SR, Harvey NC, Cooper C, Duijts L, Heude B, Hébert JR, McAuliffe FM, Kelleher CC, Phillips CM. Associations of maternal dietary inflammatory potential and quality with offspring birth outcomes: An individual participant data pooled analysis of 7 European cohorts in the ALPHABET consortium. PLoS Med. 2021 Jan 21;18(1):e1003491. doi: 10.1371/journal.pmed.1003491. eCollection 2021 Jan. PMID: 33476335. Chen LW, Aubert AM, Shivappa N, Bernard JY, Mensink-Bout SM, Geraghty AA, Mehegan J, Suderman M, Polanska K, Hanke W, Jankowska A, Relton CL, Crozier SR, Harvey NC, Cooper C, Hanson M, Godfrey KM, Gaillard R, Duijts L, Heude B, Hébert JR, McAuliffe FM, Kelleher CC, Phillips CM. Maternal dietary quality, inflammatory potential and childhood adiposity: an individual participant data pooled analysis of seven European cohorts in the alphabet consortium. BMC Med. 2021 Feb 22;19(1):33. doi: 10.1186/s12916-021-01908-7. PMID: 33612114.
Start Year 2017
 
Description Alcohol Exposure 
Organisation University of Toronto
Department Baycrest Centre for Geriatric Care
Country Canada 
Sector Academic/University 
PI Contribution Joint analysis of ALSPAC (epigenetic) data and imaging phenotypes obtained by Toronto group
Collaborator Contribution Imaging phenotypes obtained by Toronto group
Impact PhD thesis completed on the relationship between prenatal alcohol exposure, own alcohol use and neuroimaging phenotypes.
Start Year 2016
 
Description BIOMAP- Biomarkers in Atopic Dermatitis and Psoriasis 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Josine Min is a task PI of WP3. She developed templates for data access for third party datasets and as custodian for a number of datasets has submitted data applications for the consortium. We finalised the extended collection of an eczema ALSPAC sub-study (PAXGENE tube, PBMC tube and skin biopsy). We contributed to the development of the BIOMAP glossary, contributed to the pre-processing and analysis pipeline of BIOMAP WP2 by contributing software (R packages meffil, EWAFF, DMRFF). We generated analysis plans to conduct an EWAS and a TWAS across a large number of datasets for AD and Psoriasis endotypes.
Collaborator Contribution The European research project BIOMAP (Biomarkers in Atopic Dermatitis and Psoriasis) is the first large-scale multinational public-private partnership on chronic inflammatory skin diseases. This five-year project will address key unmet needs in understanding atopic dermatitis and psoriasis by analysing data from more than 50,000 patients, and have a broad impact on improving disease understanding, patient care and development of future therapies (www.biomap-imi.eu). The team comprises 26 academic and five industry partners as well as five patient organisations from 12 countries. The partner organisation make a wide range of contributions to consortium activities.
Impact The team comprises 26 academic and five industry partners as well as five patient organisations from 12 countries. The team has dermatologists, bioinformaticians, epidemiologists etc.
Start Year 2019
 
Description BIOMAP- Biomarkers in Atopic Dermatitis and Psoriasis 
Organisation University of Kiel
Country Germany 
Sector Academic/University 
PI Contribution Josine Min is a task PI of WP3. She developed templates for data access for third party datasets and as custodian for a number of datasets has submitted data applications for the consortium. We finalised the extended collection of an eczema ALSPAC sub-study (PAXGENE tube, PBMC tube and skin biopsy). We contributed to the development of the BIOMAP glossary, contributed to the pre-processing and analysis pipeline of BIOMAP WP2 by contributing software (R packages meffil, EWAFF, DMRFF). We generated analysis plans to conduct an EWAS and a TWAS across a large number of datasets for AD and Psoriasis endotypes.
Collaborator Contribution The European research project BIOMAP (Biomarkers in Atopic Dermatitis and Psoriasis) is the first large-scale multinational public-private partnership on chronic inflammatory skin diseases. This five-year project will address key unmet needs in understanding atopic dermatitis and psoriasis by analysing data from more than 50,000 patients, and have a broad impact on improving disease understanding, patient care and development of future therapies (www.biomap-imi.eu). The team comprises 26 academic and five industry partners as well as five patient organisations from 12 countries. The partner organisation make a wide range of contributions to consortium activities.
Impact The team comprises 26 academic and five industry partners as well as five patient organisations from 12 countries. The team has dermatologists, bioinformaticians, epidemiologists etc.
Start Year 2019
 
Description Biogen Idec 
Organisation Biogen Idec
Department MR and Epigenetics Industry Translation
Country United Kingdom 
Sector Private 
PI Contribution We have hosted and visited Biogen Idec to pursue collaborative links around discovery science in epigenetics.
Collaborator Contribution Invitation to contribute to a Genomics Workshop at Biogen Idec and liaison regarding future collaboration
Impact A collaborative agreement is being formulated.
Start Year 2013
 
Description Bristol City Council 
Organisation Bristol City Council
Country United Kingdom 
Sector Public 
PI Contribution C Rlton: PI of the study and provides advice to BCC on COVID-related research.
Collaborator Contribution Partnership in the design and delivery of a COVID-19 study of Bristol schools.
Impact Newsletters, media coverage and other outputs are detailed on the study website.
Start Year 2020
 
Description Brown & Shahab - Targeting multiple levels of the smoking cessation system using novel scientific approaches. 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Contributing towards the epigenetic assessment of novel nicotine product users. Support for the programme including time to attend strategic management meetings, advise on research questions, contribute to PhD student placements and enable pathways to impact.
Collaborator Contribution CRUK Programme Grant Renewal
Impact N/A
Start Year 2021
 
Description Copenhagen University 
Organisation Copenhagen University Hospital
Country Denmark 
Sector Academic/University 
PI Contribution We bring epigenetic epidemiology expertise. This collaboration is focused around the exploration of DNA methylation as an intermediate linking cigarette smoke exposure to a wide range of health outcomes.
Collaborator Contribution The collaborators bring access to and biosamples from their very large population based resources, namely the Copenhagen City Heart Study
Impact Manuscripts under submission and further papers are in preparation.
Start Year 2013
 
Description Dalgaard - Epigenetic factors in cardiometabolic disease: a study of discordant MZ twins 
Organisation University of Southern Denmark
Country Denmark 
Sector Academic/University 
PI Contribution Intellectual contributions, generation of DNA methylation data
Collaborator Contribution GEMINAKAR study: Intellectual contributions, sample provision, genetic data provision
Impact No outputs yet
Start Year 2021
 
Description Dunn (Harvard/MGH) 
Organisation Massachusetts General Hospital
Department Psychiatric & Neurodevelopmental Genetics Unit
Country United States 
Sector Hospitals 
PI Contribution Prof C Relton; Co-I and collaborator or various grants with Dr. Dunn. Provide periodic advice and guidance on research strategy and methods. Support access to group's expertise and resources to explore stated hypotheses. Dr Matt Suderman; Partner- Expertise in social and psychiatric epidemiology. Aim is to better understand the relationship of gene activity via DNA methylation with timing of adverse exposures in childhood.
Collaborator Contribution Experience and tools for analysing genome-wide DNA methylation profiles, ALSPAC cohort data.
Impact Two funded grants (NIMH: R01-MH113930-01, NIMH: renewal awarded) and four publications (PMIDs 31918390, 30905381, 32863090)
Start Year 2016
 
Description EPIC DIVE - Early PancreatIc Cancer Diagnosis In Vivo Evaluation 
Organisation NHS England
Country United Kingdom 
Sector Public 
PI Contribution Aim is investigate methods for amplifying circulating tumour DNA in vivo that could be used for early cancer detection.
Collaborator Contribution Machine learning and mathematical modelling
Impact EPIC DIVE - Early Pancreatic Cancer Diagnosis In Vivo Evaluation Research Grant (as above CRUK funded £228,000)
Start Year 2022
 
Description EPIC DIVE - Early PancreatIc Cancer Diagnosis In Vivo Evaluation 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Aim is investigate methods for amplifying circulating tumour DNA in vivo that could be used for early cancer detection.
Collaborator Contribution Machine learning and mathematical modelling
Impact EPIC DIVE - Early Pancreatic Cancer Diagnosis In Vivo Evaluation Research Grant (as above CRUK funded £228,000)
Start Year 2022
 
Description EPIC DIVE - Early PancreatIc Cancer Diagnosis In Vivo Evaluation 
Organisation University of Surrey
Country United Kingdom 
Sector Academic/University 
PI Contribution Aim is investigate methods for amplifying circulating tumour DNA in vivo that could be used for early cancer detection.
Collaborator Contribution Machine learning and mathematical modelling
Impact EPIC DIVE - Early Pancreatic Cancer Diagnosis In Vivo Evaluation Research Grant (as above CRUK funded £228,000)
Start Year 2022
 
Description EPIC DIVE - Early PancreatIc Cancer Diagnosis In Vivo Evaluation 
Organisation University of the West of England
Country United Kingdom 
Sector Academic/University 
PI Contribution Aim is investigate methods for amplifying circulating tumour DNA in vivo that could be used for early cancer detection.
Collaborator Contribution Machine learning and mathematical modelling
Impact EPIC DIVE - Early Pancreatic Cancer Diagnosis In Vivo Evaluation Research Grant (as above CRUK funded £228,000)
Start Year 2022
 
Description EPSRC - Living fast and showing off? Evaluating individual and social influences on risky behaviour 
Organisation University of Exeter
Country United Kingdom 
Sector Academic/University 
PI Contribution Project idea and design, feedback on application, supervision
Collaborator Contribution Project idea and design (TF), application writing (SH), supervision (CW, CB, MK-R)
Impact EPSRC PhD funding awarded to Steph Hunt Multidisciplinary: Psychology, epidemiology, biology, data science
Start Year 2019
 
Description ESRC Biomarker Data Project Fellowship in Understanding Society - R Richmond 
Organisation University of Essex
Department Institute for Social and Economic Research, Essex
Country United Kingdom 
Sector Academic/University 
PI Contribution Data analysis of Understanding Society data.
Collaborator Contribution Data provision for Understanding Society and mentorship.
Impact Rebecca Richmond was awarded an ESRC fellowship.
Start Year 2018
 
Description EpiPREG 
Organisation Oslo University Hospital
Country Norway 
Sector Hospitals 
PI Contribution Intellectual contributions, generation of DNA methylation data
Collaborator Contribution Intellectual contributions, sample provision, genetic data provision
Impact No outputs yet
Start Year 2021
 
Description Epigenetic ageing and biomarkers 
Organisation University of California, Los Angeles (UCLA)
Country United States 
Sector Academic/University 
PI Contribution Collaboration on research related to epigenetic ageing and biomarkers that provide a measure of this. We have led on Mendelian randomization analyses within this consortium.
Collaborator Contribution Expertise in epigenetic age measures
Impact Langdon R, Beynon RA, Ingarfield K, Marioni RE, MacCartney DM, Martin RM, Ness AR, Pawlita M, Waterboer T, Relton C, Thomas SJ, Richmond RC. Epigenetic prediction of complex traits and mortality in a cohort of individuals with oropharyngeal cancer. Clinical Epigenetics, 2020; 12: 1-14 McCartney DL*, Min JL*, Richmond RC*, Lu AT*, Sobzyk MK*, Davies G* et al. Genome-wide association studies identify 137 loci for DNA methylation biomarkers of aging. bioRxiv https://doi.org/10.1101/2020.06.29.133702 Beynon R, Ingle S, Landon R, May M, Ness A, Martin R, Suderman M, Ingarfield K, Marioni R, McCartney D, Waterboer T, Pawlita M, Relton C, Davey Smith G, Richmond RC. Epigenetic biomarkers of ageing are predictive of mortality risk in a longitudinal clinical cohort of individuals diagnosed with oropharyngeal cancer. medRxiv https://doi.org/10.1101/2020.02.04.20020198.
Start Year 2019
 
Description Epigenetic ageing and biomarkers 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration on research related to epigenetic ageing and biomarkers that provide a measure of this. We have led on Mendelian randomization analyses within this consortium.
Collaborator Contribution Expertise in epigenetic age measures
Impact Langdon R, Beynon RA, Ingarfield K, Marioni RE, MacCartney DM, Martin RM, Ness AR, Pawlita M, Waterboer T, Relton C, Thomas SJ, Richmond RC. Epigenetic prediction of complex traits and mortality in a cohort of individuals with oropharyngeal cancer. Clinical Epigenetics, 2020; 12: 1-14 McCartney DL*, Min JL*, Richmond RC*, Lu AT*, Sobzyk MK*, Davies G* et al. Genome-wide association studies identify 137 loci for DNA methylation biomarkers of aging. bioRxiv https://doi.org/10.1101/2020.06.29.133702 Beynon R, Ingle S, Landon R, May M, Ness A, Martin R, Suderman M, Ingarfield K, Marioni R, McCartney D, Waterboer T, Pawlita M, Relton C, Davey Smith G, Richmond RC. Epigenetic biomarkers of ageing are predictive of mortality risk in a longitudinal clinical cohort of individuals diagnosed with oropharyngeal cancer. medRxiv https://doi.org/10.1101/2020.02.04.20020198.
Start Year 2019
 
Description European Bioinformatics Institute 
Organisation EMBL European Bioinformatics Institute (EMBL - EBI)
Country United Kingdom 
Sector Academic/University 
PI Contribution We bring epidemiological and causal analysis expertise to this collaboration as well as generating epigenomic data for use by colleagues at EBI.
Collaborator Contribution Bioinformatic expertise for the functional annotation of observed associations.
Impact EBI have been involved in ARIES and have more recently been closely involved in formulating large strategic funding applications. The outputs of this work are too early to report. This is a multi-disciplinary collaboration between epidemiologists and bioinformaticians.
Start Year 2013
 
Description GOYA Study Copenhagen 
Organisation Copenhagen University Hospital
Country Denmark 
Sector Academic/University 
PI Contribution We have generated epigenome-wide DNA methylation data on the GOYA cohort (a study of the offspring of extremely obese individuals) and have provided advice and analytical support in the use of these data.
Collaborator Contribution The provision of biological samples for epigenetic profiling as well as associated data for analysis. Our collaborators also facilitate the acquisition of ethical permission to use the data for new analyses.
Impact As a consequence of this collaboration GOYA is now part of the PACE study and features in various manuscripts that are currently in preparation led by my group.
Start Year 2013
 
Description GW4 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution The GW4 strategic alliance has established the GW4 Epigenetics Consortium which I instigated and brings complementary expertise from the 4 contributing Universitites together.We hosted a 2 day symposium and workshops and have subsequently secured and undertaken research activities around the use of CRISPR/Cas9 in epigenetics studies
Collaborator Contribution 2 day symposium and workshops. Epidemiology expertise.
Impact 2 day symposium and workshops. Further grant application to GW4 for research activities. This is a multi-disciplinary collaboration between epidemiologists, clinicians, experimental biologists, bioinformaticians and epigeneticists
Start Year 2014
 
Description GW4 
Organisation University of Bath
Country United Kingdom 
Sector Academic/University 
PI Contribution The GW4 strategic alliance has established the GW4 Epigenetics Consortium which I instigated and brings complementary expertise from the 4 contributing Universitites together.We hosted a 2 day symposium and workshops and have subsequently secured and undertaken research activities around the use of CRISPR/Cas9 in epigenetics studies
Collaborator Contribution 2 day symposium and workshops. Epidemiology expertise.
Impact 2 day symposium and workshops. Further grant application to GW4 for research activities. This is a multi-disciplinary collaboration between epidemiologists, clinicians, experimental biologists, bioinformaticians and epigeneticists
Start Year 2014
 
Description GW4 
Organisation University of Exeter
Country United Kingdom 
Sector Academic/University 
PI Contribution The GW4 strategic alliance has established the GW4 Epigenetics Consortium which I instigated and brings complementary expertise from the 4 contributing Universitites together.We hosted a 2 day symposium and workshops and have subsequently secured and undertaken research activities around the use of CRISPR/Cas9 in epigenetics studies
Collaborator Contribution 2 day symposium and workshops. Epidemiology expertise.
Impact 2 day symposium and workshops. Further grant application to GW4 for research activities. This is a multi-disciplinary collaboration between epidemiologists, clinicians, experimental biologists, bioinformaticians and epigeneticists
Start Year 2014
 
Description GW4 - Brain age as a marker of mental and physical well-being 
Organisation University of Exeter
Country United Kingdom 
Sector Academic/University 
PI Contribution Project idea and design, feedback on application, supervision
Collaborator Contribution Project idea and design, application, supervision
Impact GW4-BioMed DTP PhD funding awarded to Constantinos Constantinides Multidisciplinary: Psychology, epidemiology, psychiatry
Start Year 2019
 
Description GoDMC: Genetics of DNA Methylation Consortium 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution We are currently leading the GoDMC consortium. The GoDMC consortium consists of five core groups (IEU, Kings College London, University of Exeter, Leiden University Medical Centre and Austrian Academy of Sciences) and we recruited 30+ cohorts to contribute to the GoDMC consortium. We have led the analysis effort for this consortium, led the writing of the main manuscript and are co-ordinating the ongoing consortium activities. Matt Suderman and Josine Min have developed an R package "Efficient algorithms for analyzing DNA methylation data" (meffil) (https://github.com/perishky/meffil) which is designed to conduct quality control and normalization of large-scale methylation datasets. Meffil also conducts epigenome wide association studies (EWAS) using four different methods. In addition, Josine Min and Gibran Hemani have written a pipeline on github, which automates all analyses. Participating cohorts will download the pipeline and will follow instructions to run the pipeline.
Collaborator Contribution Partners have ade substantive contributions to the analysis effort, to data provision and to interpretation of data generated.
Impact Software development: R package meffil and github pipeline for GoDMC analyses Disciplines: Genetic epidemiology, epigenetic epidemiology Main manuscript, published in Nature Genetics. PMID: 34493871 Summary genetic association data have been deposited and are available for open access. Follow up studies planned and underway.
Start Year 2013
 
Description GoDMC: Genetics of DNA Methylation Consortium 
Organisation Leiden University Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution We are currently leading the GoDMC consortium. The GoDMC consortium consists of five core groups (IEU, Kings College London, University of Exeter, Leiden University Medical Centre and Austrian Academy of Sciences) and we recruited 30+ cohorts to contribute to the GoDMC consortium. We have led the analysis effort for this consortium, led the writing of the main manuscript and are co-ordinating the ongoing consortium activities. Matt Suderman and Josine Min have developed an R package "Efficient algorithms for analyzing DNA methylation data" (meffil) (https://github.com/perishky/meffil) which is designed to conduct quality control and normalization of large-scale methylation datasets. Meffil also conducts epigenome wide association studies (EWAS) using four different methods. In addition, Josine Min and Gibran Hemani have written a pipeline on github, which automates all analyses. Participating cohorts will download the pipeline and will follow instructions to run the pipeline.
Collaborator Contribution Partners have ade substantive contributions to the analysis effort, to data provision and to interpretation of data generated.
Impact Software development: R package meffil and github pipeline for GoDMC analyses Disciplines: Genetic epidemiology, epigenetic epidemiology Main manuscript, published in Nature Genetics. PMID: 34493871 Summary genetic association data have been deposited and are available for open access. Follow up studies planned and underway.
Start Year 2013
 
Description Goulder (Oxford University) 
Organisation University of Oxford
Department Oxford University Innovation
Country United Kingdom 
Sector Private 
PI Contribution Dr Matt Suderman; Partner- Clinical knowledge, expert on immune responses in children, laboratory tools and skills, South African cohort, Aim is to investigate mechanisms causing sex-discordance in immune responses in early life using samples and data collected longitudinally from birth to adulthood.
Collaborator Contribution Knowledge and experience with omic data, especially DNA methylation, ALSPAC cohort data, preprint on sex differences in DNA methylation (https://doi.org/10.1101/118265)
Impact Grant application to Wellcome Trust submitted Feb 16, 2021 (Suderman is co-investigator)
Start Year 2020
 
Description HUNT Study Collaboration 
Organisation Norwegian University of Science and Technology (NTNU)
Department Medical Technical Institute; Norwegian Technical University of Trondheim
Country Norway 
Sector Academic/University 
PI Contribution Expertise in epigenetic epidemiology, prediction analysis and Mendelian randomization. Studies have been completed to analyse DNA methylation profiles on biological samples from HUNT study participants. Additional new studies are underway, described in other another collaboration entry.
Collaborator Contribution Analysis of data within the HUNT study
Impact Sun YQ, Richmond RC, Suderman M, Min JL, Battram T, Flatberg A, Beisvag V, Nost TH, Guida F, Jiang L, Wahl SGF, Langhammer A, Skorpen F, Walker RM, Bretherick AD, Zeng Y, Chen Y, Johansson M, Sandanger T, Relton C, Mai XM. Assessing the role of genome-wide DNA methylation between smoking and risk of lung cancer using repeated measurements: the HUNT Study. International Journal of Epidemiology (in press) Sun YG, Richmond RC, Chen Y, Mai X. Mixed evidence for the relationship between periodontitis and Alzheimer's disease: A bidirectional Mendelian randomization study. PLOS ONE, 2020; 15(1): e0228206 Lane JM, Jones S, Dashti H, Wood A, Aragam K, van Hees VT, Brumpton B, Wisvold BS, Wang H, Bowden J, Song T, Patel K, Anderson SG, Beaumont R, Bechtold DA, Cade B, Kathiresan S, Little MA, Luik AI, Loudon AS, Purcell S, Richmond RC, et al. Biological and clinical insights from genetics of insomnia symptoms. Nature Genetics, 2019; 51(3):387
Start Year 2016
 
Description Head & Neck Cancer Research 
Organisation German Cancer Research Center
Country Germany 
Sector Academic/University 
PI Contribution Expertise on epigenetic epidemiology and Mendelian randomization
Collaborator Contribution Access to head and neck cancer studies. HeadSpace, Voyager and Head and Neck 5000 are examples of contributing studies.
Impact Gormley M, Dudding T, Sanderson E, Martin R, Thomas S, Tyrrell J, Ness A, Brennan P, Munafo M, Pring M, Boccia S, Olshan A, Diergaarde B, Hung R, Liu G, Davey Smith G, Richmond RC. Investigating smoking and alcohol consumption in oral and oropharyngeal cancer: a multivariable Mendelian randomization analysis. Nature Communications (in press) Langdon R, Richmond RC, Elliott HR, Dudding T, Kazmi N, Penfold C, Ingarfield K, Ho K, Bretherick A, Haley C, Zeng Y, Walker RM, Pawlita M, Waterboer T, Ring S, Gaunt T, Davey Smith G, Suderman M, Thomas S, Ness A, Relton C. Identifying epigenetic biomarkers of established prognostic factors and survival in a clinical cohort of individuals with oropharyngeal cancer. Clinical Epigenetics, 2020; 12(1), 1-19 Langdon R, Beynon RA, Ingarfield K, Marioni RE, MacCartney DM, Martin RM, Ness AR, Pawlita M, Waterboer T, Relton C, Thomas SJ, Richmond RC. Epigenetic prediction of complex traits and mortality in a cohort of individuals with oropharyngeal cancer. Clinical Epigenetics, 2020; 12: 1-14 Ambatipudi S, Langdon R, Richmond RC, Suderman M, Koestler DC, Kelsey KT, Kazmi N, Penfold C, Ho KM, McArdle W, Ring SW, Pring M, Waterboer T, Pawlita M, Gaunt TR, Davey Smith G, Thomas S, Ness AR, Relton CL. DNA methylation derived systemic inflammation indices are associated with head and neck cancer development and survival. Oral Oncology 2018; 85:87-94 Gormley M, Yarmolinsky J, Dudding T, Burrows K, Martin RM, Thomas S, Tyrrell J, Brennan P, Pring M, Boccia S, Olshan AF, Diergaarde B, Hung RJ, Liu G, Legge D, Tajara EH, Severino P, Lack M, Ness AR, Davey Smith G, Vincent EE, Richmond RC. Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: a Mendelian randomization study. medRxiv https://doi.org/10.1101/2020.10.05.20206268
Start Year 2016
 
Description Head & Neck Cancer Research 
Organisation International Agency for Research on Cancer (IARC)
Country France 
Sector Academic/University 
PI Contribution Expertise on epigenetic epidemiology and Mendelian randomization
Collaborator Contribution Access to head and neck cancer studies. HeadSpace, Voyager and Head and Neck 5000 are examples of contributing studies.
Impact Gormley M, Dudding T, Sanderson E, Martin R, Thomas S, Tyrrell J, Ness A, Brennan P, Munafo M, Pring M, Boccia S, Olshan A, Diergaarde B, Hung R, Liu G, Davey Smith G, Richmond RC. Investigating smoking and alcohol consumption in oral and oropharyngeal cancer: a multivariable Mendelian randomization analysis. Nature Communications (in press) Langdon R, Richmond RC, Elliott HR, Dudding T, Kazmi N, Penfold C, Ingarfield K, Ho K, Bretherick A, Haley C, Zeng Y, Walker RM, Pawlita M, Waterboer T, Ring S, Gaunt T, Davey Smith G, Suderman M, Thomas S, Ness A, Relton C. Identifying epigenetic biomarkers of established prognostic factors and survival in a clinical cohort of individuals with oropharyngeal cancer. Clinical Epigenetics, 2020; 12(1), 1-19 Langdon R, Beynon RA, Ingarfield K, Marioni RE, MacCartney DM, Martin RM, Ness AR, Pawlita M, Waterboer T, Relton C, Thomas SJ, Richmond RC. Epigenetic prediction of complex traits and mortality in a cohort of individuals with oropharyngeal cancer. Clinical Epigenetics, 2020; 12: 1-14 Ambatipudi S, Langdon R, Richmond RC, Suderman M, Koestler DC, Kelsey KT, Kazmi N, Penfold C, Ho KM, McArdle W, Ring SW, Pring M, Waterboer T, Pawlita M, Gaunt TR, Davey Smith G, Thomas S, Ness AR, Relton CL. DNA methylation derived systemic inflammation indices are associated with head and neck cancer development and survival. Oral Oncology 2018; 85:87-94 Gormley M, Yarmolinsky J, Dudding T, Burrows K, Martin RM, Thomas S, Tyrrell J, Brennan P, Pring M, Boccia S, Olshan AF, Diergaarde B, Hung RJ, Liu G, Legge D, Tajara EH, Severino P, Lack M, Ness AR, Davey Smith G, Vincent EE, Richmond RC. Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: a Mendelian randomization study. medRxiv https://doi.org/10.1101/2020.10.05.20206268
Start Year 2016
 
Description Head & Neck Cancer Research 
Organisation University of Pittsburgh Cancer Institute
Country United States 
Sector Public 
PI Contribution Expertise on epigenetic epidemiology and Mendelian randomization
Collaborator Contribution Access to head and neck cancer studies. HeadSpace, Voyager and Head and Neck 5000 are examples of contributing studies.
Impact Gormley M, Dudding T, Sanderson E, Martin R, Thomas S, Tyrrell J, Ness A, Brennan P, Munafo M, Pring M, Boccia S, Olshan A, Diergaarde B, Hung R, Liu G, Davey Smith G, Richmond RC. Investigating smoking and alcohol consumption in oral and oropharyngeal cancer: a multivariable Mendelian randomization analysis. Nature Communications (in press) Langdon R, Richmond RC, Elliott HR, Dudding T, Kazmi N, Penfold C, Ingarfield K, Ho K, Bretherick A, Haley C, Zeng Y, Walker RM, Pawlita M, Waterboer T, Ring S, Gaunt T, Davey Smith G, Suderman M, Thomas S, Ness A, Relton C. Identifying epigenetic biomarkers of established prognostic factors and survival in a clinical cohort of individuals with oropharyngeal cancer. Clinical Epigenetics, 2020; 12(1), 1-19 Langdon R, Beynon RA, Ingarfield K, Marioni RE, MacCartney DM, Martin RM, Ness AR, Pawlita M, Waterboer T, Relton C, Thomas SJ, Richmond RC. Epigenetic prediction of complex traits and mortality in a cohort of individuals with oropharyngeal cancer. Clinical Epigenetics, 2020; 12: 1-14 Ambatipudi S, Langdon R, Richmond RC, Suderman M, Koestler DC, Kelsey KT, Kazmi N, Penfold C, Ho KM, McArdle W, Ring SW, Pring M, Waterboer T, Pawlita M, Gaunt TR, Davey Smith G, Thomas S, Ness AR, Relton CL. DNA methylation derived systemic inflammation indices are associated with head and neck cancer development and survival. Oral Oncology 2018; 85:87-94 Gormley M, Yarmolinsky J, Dudding T, Burrows K, Martin RM, Thomas S, Tyrrell J, Brennan P, Pring M, Boccia S, Olshan AF, Diergaarde B, Hung RJ, Liu G, Legge D, Tajara EH, Severino P, Lack M, Ness AR, Davey Smith G, Vincent EE, Richmond RC. Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: a Mendelian randomization study. medRxiv https://doi.org/10.1101/2020.10.05.20206268
Start Year 2016
 
Description Head & Neck Cancer Research 
Organisation University of Toronto
Country Canada 
Sector Academic/University 
PI Contribution Expertise on epigenetic epidemiology and Mendelian randomization
Collaborator Contribution Access to head and neck cancer studies. HeadSpace, Voyager and Head and Neck 5000 are examples of contributing studies.
Impact Gormley M, Dudding T, Sanderson E, Martin R, Thomas S, Tyrrell J, Ness A, Brennan P, Munafo M, Pring M, Boccia S, Olshan A, Diergaarde B, Hung R, Liu G, Davey Smith G, Richmond RC. Investigating smoking and alcohol consumption in oral and oropharyngeal cancer: a multivariable Mendelian randomization analysis. Nature Communications (in press) Langdon R, Richmond RC, Elliott HR, Dudding T, Kazmi N, Penfold C, Ingarfield K, Ho K, Bretherick A, Haley C, Zeng Y, Walker RM, Pawlita M, Waterboer T, Ring S, Gaunt T, Davey Smith G, Suderman M, Thomas S, Ness A, Relton C. Identifying epigenetic biomarkers of established prognostic factors and survival in a clinical cohort of individuals with oropharyngeal cancer. Clinical Epigenetics, 2020; 12(1), 1-19 Langdon R, Beynon RA, Ingarfield K, Marioni RE, MacCartney DM, Martin RM, Ness AR, Pawlita M, Waterboer T, Relton C, Thomas SJ, Richmond RC. Epigenetic prediction of complex traits and mortality in a cohort of individuals with oropharyngeal cancer. Clinical Epigenetics, 2020; 12: 1-14 Ambatipudi S, Langdon R, Richmond RC, Suderman M, Koestler DC, Kelsey KT, Kazmi N, Penfold C, Ho KM, McArdle W, Ring SW, Pring M, Waterboer T, Pawlita M, Gaunt TR, Davey Smith G, Thomas S, Ness AR, Relton CL. DNA methylation derived systemic inflammation indices are associated with head and neck cancer development and survival. Oral Oncology 2018; 85:87-94 Gormley M, Yarmolinsky J, Dudding T, Burrows K, Martin RM, Thomas S, Tyrrell J, Brennan P, Pring M, Boccia S, Olshan AF, Diergaarde B, Hung RJ, Liu G, Legge D, Tajara EH, Severino P, Lack M, Ness AR, Davey Smith G, Vincent EE, Richmond RC. Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: a Mendelian randomization study. medRxiv https://doi.org/10.1101/2020.10.05.20206268
Start Year 2016
 
Description Hemmings (Stellenbosch) 
Organisation University of Stellenbosch
Country South Africa 
Sector Academic/University 
PI Contribution Dr Matt Suderman; Partner- Expert in fetal alcohol syndrome and trauma, human cohort with high alcohol exposure To identify biomarkers of high alcohol intake and fetal alcohol syndrome in peripheral tissues collected from pregnant mothers.
Collaborator Contribution Knowledge and tools for analyzing DNA methylation profiles and using them to create and validate predictors.
Impact Two unsuccessful grant applications (MRC and Wellcome Trust) and one publication (PMID 34799556).
Start Year 2018
 
Description IARC 
Organisation International Agency for Research on Cancer (IARC)
Country France 
Sector Academic/University 
PI Contribution This long-standing collaboration (consolidated by a short sabbatical in 2008) led to a large scale NIH funded biomarker study which is ongoing. More recently, a CRUK programme in integrative cancer epidemiology has been awarded on which I am Co-PI. I bring programme leadership and epigenetic epidemiology and causal analysis expertise.
Collaborator Contribution Genetic epidemiology and access to large multi-national consortia.
Impact P Brennan, M Johansson, CL Relton, PM Ueland, P Vineis et al. One carbon metabolism biomarkers and lung cancer risk. Sep 2011-Aug 2016 NIH/NCI R01 [$5,060,000] Co-I Martin RM (Co-PI), Relton CL (Co-PI) et al. Reducing the burden of cancer: Causal risk factors, mechanistic targets and predictive biomarkers. £4.15M. CRUK Programme. Jun 2015 - May 2020. Johansson M, Fanidi A, Muller D, Bassett J, Midttun Ø, Vollset SE, Travis R, Palli D, Mattiello A, Sieri S, Trichopoulou A, Lagiou P, Trichopoulos D, Ljungberg B, Hallmans G, Weiderpass E, Skeie G, González C, Dorronsoro M, Peeters P, Bueno-de-Mesquita HB, Ros M, Boutron-Ruault MC, Fagherazzi G, Clavel-Chapelon F, Sánchez MJ, Barricarte Gurea A, Navarro C, Quirós JR, Overvad K, Tjønneland A, Aleksandrova K, Vineis P, Gunter M, Giles G, Relton C, Riboli E, Boeing H, Ueland PM, Severi G, Brennan P. Circulating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survival. J Natl Cancer Inst 2014;106(12):pii. PMID: 25376861 Fanidi A, Relton CL, Ueland PM, Midtun Ø, Vollset SE, Travis RC, Trichopoulou A, Lagiou P, Trichopoulos D, Bueno-de-Mesquita HB, Ros M, Boeing H, Tumino R, Panico S, Palli D, Sieri S, Vineis P, Sánchez MJ, Huerta JM, Barricarte Gurrea A, Luján-Barroso L, Quirós JR, Tjønneland A, Halkjær J, Boutron-Ruault MC, Clavel-Chapelon F, Cadeau C, Weiderpass E, Johansson M, Riboli E, Brennan P, Johansson M. A prospective study of one-carbon metabolism biomarkers and cancer of the head, neck and oesophagus. Int J Cancer 2014;136(4):915-27. PMID: 24975698 Fasanelli F, Baglietto L, Ponzi E, Guida F, Campanella G, Johansson M, Grankvist K, Johansson M, Assumma MB, Naccarati A, Chadeau-Hyam M, Ala U, Faltus C, Kaaks R, Risch A, De Stavola B, Hodge A, Giles GG, Southey MC, Relton CL, Haycock PC, Lund E, Polidoro S, Sandanger TM, Severi G, Vineis P. Hypomethylation of smoking-related gene is associated with future lung cancer in four prospective cohorts. Nat Commun 2015 Dec 15;6:10192. doi: 10.1038/ncomms10192. PMID: 26667048 Multiple additional manuscripts. Renewal of CRUK-funded programme grant from 2020-2025, with a larger body of research planned.
Start Year 2007
 
Description Jean Golding- University of Bristol 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Dr Matt Suderman; Partner and Co-I - Expert on human cohorts, especially the ALSPAC cohort. To identify biological effects and consequences of ancestral exposures on DNA methylation in a transgenerational framework.
Collaborator Contribution Knowledge and tools for analyzing DNA methylation profiles
Impact Six publications (PMIDs 33043146, 31659193, 35064168, 34170302, 33842694, one in press)
Start Year 2017
 
Description Jones (University of Bristol) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Dr Matt Suderman; Partner-Bat cohort data and samples, expert knowledge of bats. Aim is to better understand aging by investigating DNA methylation in bat species with extremely long lifespans.
Collaborator Contribution Experience and tools for analysing genome-wide DNA methylation profiles and using to it evaluate biological aging and determinants.
Impact None yet (one unsuccessful grant to BBSRC and one new submission to NERC with Suderman as co-investigator)
Start Year 2020
 
Description KCL - Epigenetics 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution We bring epidemiological expertise and expertise in causal analysis methodology to a series of collaborations. We have collaborated on joint research proposals which have been successful.
Collaborator Contribution Our collaborators bring the following expertise; Dr Helen Fisher: Social Science and Psychiatry Dr Ted Barker: Conduct problems Dr Jordana Bell; Twin studies
Impact Dr Fisher was awarded a MQ Fellowship on which I act as a sponsor. We are Co-Investigators on a recently awarded ESRC grant; Howe L, Relton CL (Co-I), Davey Smith G, Gaunt T, Suderman M, Simpkin A, Davies N, Shihab H, Marioni R, Hardy R, Wong C, Fisher H, John R, Jerrim J, Deary I, Mill J. Interpreting epigenetic signatures in studies of early life adversity (InterSTELA) ESRC. £195,513. Drs Bell and Fisher is a collaborator on a further ESRC grant of which I am PI; Relton CL (PI), Davey Smith G, Power C, Deary I, Davies N, Tilling K, Gaunt T, Munafo M, Windmeijer F, Visscher P, Marioni R, Ingram N, van den Berg G, Murtagh M. Epigenetics: Environment, Embodiment and Equality (E4). ESRC. £667,460. We have collaborated with Dr Barker on a NIH-funded project; E Barker, J Mill, G Davey Smith, B Maughan, CL Relton. Epigenetic pathways to conduct problem trajectories: the role of prenatal and postnatal environmental risk exposures. Jan 2012-Dec 2016 NIH/NICHD [£1,100,000] Co-I. With the following outputs; Cecil CAM, Lysenko LJ, Jaffee SR, Pingault J-B, Smith RG, Relton CL, Woodward G, McArdle W, Mill J, Barker ED. Environmental risk, oxytocin receptor gene (OXTR) methylation and youth callous-unemotional traits: A 13-year longitudinal study. Mol Psychiatry 2014;19(10):1071-7. PMID: 25199917 Rijlaarsdam J, Pappa I, Walton E, Bakermans-Kranenburg MJ, Mileva-Seitz VR, Rippe RC, Roza SJ, Jaddoe VW, Verhulst FC, Felix JF, Cecil CA, Relton CL, Gaunt TR, McArdle W, Mill J, Barker ED, Tiemeier H, van Ijzendoom MH. An epigenome-wide association meta-analysis of prenatal maternal stress in neonates: A model approach for replication. Epigenetics 2016. In Press. Further papers are under review. Dr Bell is a co-PI of the Genetics of DNA Methylation Consortium (GoDMC).
Start Year 2013
 
Description Krieger - Harvard School of Public Health 
Organisation Harvard University
Department Harvard T.H. Chan School of Public Health
Country United States 
Sector Academic/University 
PI Contribution Epigenetic epidemiology expertise
Collaborator Contribution Social epidemiology and social determinants of health. This collaboration, primarily with Prof Nancy Krieger, involves collaboration on biosocial epigenetics research. Prof Krieger leads a unique study on racial and economic discrimination on which we are conducting epigenetic studies. NIH R01 funded in 2020 to run for 3 years 7 months. Relton & Krieger MPIs.
Impact Collaborators are involved in Relton CL (PI), Davey Smith G, Power C, Deary I, Davies N, Tilling K, Gaunt T, Munafo M, Windmeijer F, Visscher P, Marioni R, Ingram N, van den Berg G, Murtagh M. Epigenetics: Environment, Embodiment and Equality (E4). ESRC. £667,460. Krieger N (MPI), Relton CL (MPI), Waterman PD, Chen JT, Coull BA, De Vivo I, Diez-Roux A, Davey Smith G, Simpkin AJ, Tilling K, Suderman MJ, Freeman E. DNA methylation & adversity: pathways from exposures to health inequities. NIH (1R01MD014304). Sep 2019 - Aug 2023. $2,352,682/£1,742,728.
Start Year 2014
 
Description Leiden University Medical Centre 
Organisation Leiden University Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution We have collaborated on the ARIES study which included the profiling of DNA methylation in autopsy samples provided by Dr Bas Heijman's group at LUMC in our Bristol labs. We have cleaned and QC'd the data and contributed to data analysis. We also work closely with this group in leading the Genetics of DNA Methylation Consortium (GoDMC).
Collaborator Contribution Our collaborators provided autopsy biological samples and associated data. They have led the data analysis and preparation of findings for publication.
Impact A Data Resource Profile has been published; Relton CL, Gaunt T, McArdle W, Ho K, Duggirala A, Shihab H, Woodward G, Lyttleton O, Evans DM, Reik W, Paul YL, Ficz G, Ozanne SE, Wipat A, Flanagan K, Lister A, Heijmans BT, Ring SM, Davey Smith G. Data Resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES). Int J Epidemiol 2015;44(4):1181-90. PMID: 25991711 A further publication describing methylation profiles in different tissues is in preparation.
Start Year 2013
 
Description Lightman & Upton (University of Bristol) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Aim is to investigate circadian rhythm in DNA methylation in serially collected blood samples across a circadian rhythm disruption.
Collaborator Contribution Funds for sample storage and DNA methylation profiles, DNA methylation data generation, data analysis
Impact No outcomes yet
Start Year 2022
 
Description Longitudinal Epigenetics GenR - E Walton 
Organisation Erasmus MC
Country Netherlands 
Sector Hospitals 
PI Contribution joint analysis of ALSPAC and GenR epigenetic data
Collaborator Contribution joint analysis of ALSPAC and GenR epigenetic data
Impact Walton E, Relton CL, Caramaschi D. Using openly accessible resources to strengthen causal inference in epigenetic epidemiology of neurodevelopment and mental health. Genes 2019 Mar 1;10(3). pii: E193. doi: 10.3390/genes10030193. PMID:308903164. Caramaschi D, Hatcher C, Mulder R, Felix JF, Cecil CAM, Relton CL, Walton E. Epigenome-wide association study of seizures in childhood and adolescence. Clin Epigen. 2020 Jan 8;12(1):8. doi: 10.1186/s13138-019-0793-z. PMID:31915053. Mulder RH, Walton E, Neumann A, Houtepen LC, Felix JF, Bakermans-Kranenburg MJ, Suderman M, Tiemeier H, van IJzendoorn MH, Relton CL, Cecil CAM. Epigenomics of being bullied: changes in DNA methylation following bullying exposure. Epigenetics. 2020 Jan 28:1-15. Doi: 10.1080/15592294.2020.1719303. PMID:31992121. Sammallahti S, Cortes Hidalgo AP, Tuominen S, Malmberg A, Mulder RH, Brunst KJ, Alemany S, McBride NS, Yousefi P, Heiss JA, McRae N, Page CM, Jin J, Pesce G, Caramaschi D, Rifas-Shiman SL, Koen N, Adams CD, Magnus MC, Baïz N, Ratanatharathorn A, Czamara D, Håberg SE, Colicino E, Baccarelli AA, Cardenas A, DeMeo DL, Lawlor DA, Relton CL, Felix JF, van IJzendoorn MH, Bakermans-Kranenburg MJ, Kajantie E, Räikkönen K, Sunyer J, Sharp GC, Houtepen LC, Nohr EA, Sørensen TIA, Téllez-Rojo MM, Wright RO, Annesi-Maesano I, Wright J, Hivert MF, Wright RJ, Zar HJ, Stein DJ, London SJ, Cecil CAM, Tiemeier H, Lahti J. Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation. Mol Psychiatry. 2021 Jan 7. doi: 10.1038/s41380-020-00976-0. Online ahead of print. PMID: 33414500. van Dongen J, Hagenbeek FA, Suderman M, Roetman PJ, Sugden K, Chiocchetti AG, Ismail K, Mulder RH, Hafferty JD, Adams MJ, Walker RM, Morris SW, Lahti J, Küpers LK, Escaramis G, Alemany S, Jan Bonder M, Meijer M, Ip HF, Jansen R, Baselmans BML, Parmar P, Lowry E, Streit F, Sirignano L, Send TS, Frank J, Jylhävä J, Wang Y, Mishra PP, Colins OF, Corcoran DL, Poulton R, Mill J, Hannon E, Arseneault L, Korhonen T, Vuoksimaa E, Felix JF, Bakermans-Kranenburg MJ, Campbell A, Czamara D, Binder E, Corpeleijn E, Gonzalez JR, Grazuleviciene R, Gutzkow KB, Evandt J, Vafeiadi M, Klein M, van der Meer D, Ligthart L; BIOS Consortium, Kluft C, Davies GE, Hakulinen C, Keltikangas-Järvinen L, Franke B, Freitag CM, Konrad K, Hervas A, Fernández-Rivas A, Vetro A, Raitakari O, Lehtimäki T, Vermeiren R, Strandberg T, Räikkönen K, Snieder H, Witt SH, Deuschle M, Pedersen NL, Hägg S, Sunyer J, Franke L, Kaprio J, Ollikainen M, Moffitt TE, Tiemeier H, van IJzendoorn MH, Relton C, Vrijheid M, Sebert S, Jarvelin MR, Caspi A, Evans KL, McIntosh AM, Bartels M, Boomsma DI. DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan. Mol Psychiatry. 2021 Jan 8. doi: 10.1038/s41380-020-00987-x. Online ahead of print. PMID: 33420481. Mulder RH, Neumann A, Cecil CAM, Walton E, Houtepen LC, Simpkin AJ, Rijlaarsdam J, Heijmans BT, Gaunt TR, Felix JF, Jaddoe VWV, Bakermans-Kranenburg MJ, Tiemeier H, Relton CL, van IJzendoorn MH, Suderman M. Epigenome-wide change and variation in DNA methylation in childhood: Trajectories from birth to adolescence. Hum Mol Genet. Jan 15:ddaa280. doi: 10.1093/hmg/ddaa280. Online ahead of print. PMID: 33450751. Mulder RH (PhD candidate), Epigenetics as a mediator between the effect of peer victimization on emotional development. 4 month visit to University of Bristol Academy van der Gaag Grant. Apr-Jul 2018 (Sponsor C Relton) PhD Viva examination by C Relton: Rosa Mulder, DNA methylation and stress in child development; a population-based approach, Erasmus Medical Center, Rotterdam (PhD), January 2021
Start Year 2016
 
Description MRC Lifecourse Epidemiology Unit - Southampton 
Organisation University of Southampton
Department MRC Lifecourse Epidemiology Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution I chaired the Steering Group of a MRC-Newton Fund UK-India & Africa Project; Epigenetic mechanisms linking maternal pre-conceptional micronutrient supplementation with offspring health in India and The Gambia (2016-2018). I also continue to collaborate with epigenetics researchers at the University of Southampton, mainly in the context of meta-analytical studie4s or replication of discovery findings.
Collaborator Contribution Opportunity to contribute to a multi-national epigenetics project and share our knowledge and expertise in epigenetic epidemiology and causal analysis methods
Impact First Steering Group meeting, held in Hyderabad Feb 2016. 2nd Steering Group, held in The Gambia 2017. Various co-authored publications (middle author).
Start Year 2013
 
Description MRC The Gambia 
Organisation Medical Research Council (MRC)
Department MRC Unit, The Gambia
Country Gambia 
Sector Public 
PI Contribution Collaboration in epigenetics research. Co-investigator on recently funded award to establish a W African Bioresource in nutritional genetics and epigenetics.
Collaborator Contribution Myself and members of my team have committed to helping our colleagues at the MRC Gambia Unit establish a bioresource to support molecular epidemiology research in the future. This will involve researcher exchanges,workshops and training in Bristol and the provision of ongoing support and capacity building in The Gambia.
Impact Capacity building achieved through sharing of good practice.
Start Year 2018
 
Description MRC Unit for LIfelong Health and Ageing 
Organisation University College London
Department MRC Unit for Lifelong Health and Ageing
Country United Kingdom 
Sector Academic/University 
PI Contribution We bring epigenetics expertise to this collaboration. The NSHD (MRC 1946 Study) complements the Bristol-based ALSPAC study. I am a member of the NSHD Biosample Access Committee
Collaborator Contribution We collaborate on a variety of studies including epigenetics of the menopausal transition and the role of biosocial factors in epigenetic variation. The NSHD is a collaborating cohort on a recently awarded ESRC project grant.
Impact Relton CL (PI), Davey Smith G, Power C, Deary I, Davies N, Tilling K, Gaunt T, Munafo M, Windmeijer F, Visscher P, Marioni R, Ingram N, van den Berg G, Murtagh M. Epigenetics: Environment, Embodiment and Equality (E4). ESRC. £667,460. Howe L, Relton CL (Co-I), Davey Smith G, Gaunt T, Suderman M, Simpkin A, Davies N, Shihab H, Marioni R, Hardy R, Wong C, Fisher H, John R, Jerrim J, Deary I, Mill J. Interpreting epigenetic signatures in studies of early life adversity (InterSTELA) ESRC. £195,513.
Start Year 2013
 
Description Nagy (McGill University, Canada) 
Organisation McGill University
Country Canada 
Sector Academic/University 
PI Contribution Dr Matt Suderman; Partner- Brain bank and sequenced datasets. Aim is to better understand the aetiology of major depressive disorder in the human prefrontal cortex by analysing single-cell RNA-seq and ATAC-seq profiles. As these types of data are quite novel, secondary aims are to build and validate analysis pipelines and to discover and validate new cortex cell types.
Collaborator Contribution Knowledge and experience in handling omic datasets.
Impact Two publications (PMID 32341540, 33972803)
Start Year 2017
 
Description Norwegian Institute of Public Health 
Organisation Norwegian Institute of Public Health
Country Norway 
Sector Public 
PI Contribution We bring epigenetic epidemiology expertise to this collaboration.
Collaborator Contribution Access to a very large birth cohort as well as epidemiological and clincial expertise.
Impact Inclusion in the PACE consortium. Training and exchange visits. Preparation of joint grant applications. Joint research publications e.g. "25-hydroxyvitamin D in pregnancy and genome wide cord blood DNA methylation in two pregnancy cohorts (MoBa and ALSPAC) The Journal of Steroid Biochemistry and Molecular Biology Suderman M, Stene LC, Bohlin J, Page CM, Holvik K, Parr CL, Magnus MC, Håberg Siri E, Joubert BR, Wu MC, London SJ, Relton C, Nystad W
Start Year 2013
 
Description NutriPROGRAM consortium collaboration 
Organisation Barcelona Institute for Global Health
Country Spain 
Sector Multiple 
PI Contribution We co-designed and lead work package 4 in the Nutriprogram consortium project. We also lead or contribute to several other activities in other work packages.
Collaborator Contribution Other partners lead other work packages and contribute data and results to the work package we lead (WP4).
Impact A collaboration agreement (including DTA) has been signed by all contributing members. The collaboration is multi-disciplinary, involving epidemiologists, geneticists, nutritionists, biologists and clinicians.
Start Year 2019
 
Description NutriPROGRAM consortium collaboration 
Organisation Erasmus MC
Country Netherlands 
Sector Hospitals 
PI Contribution We co-designed and lead work package 4 in the Nutriprogram consortium project. We also lead or contribute to several other activities in other work packages.
Collaborator Contribution Other partners lead other work packages and contribute data and results to the work package we lead (WP4).
Impact A collaboration agreement (including DTA) has been signed by all contributing members. The collaboration is multi-disciplinary, involving epidemiologists, geneticists, nutritionists, biologists and clinicians.
Start Year 2019
 
Description NutriPROGRAM consortium collaboration 
Organisation Ludwig Maximilian University of Munich (LMU Munich)
Country Germany 
Sector Academic/University 
PI Contribution We co-designed and lead work package 4 in the Nutriprogram consortium project. We also lead or contribute to several other activities in other work packages.
Collaborator Contribution Other partners lead other work packages and contribute data and results to the work package we lead (WP4).
Impact A collaboration agreement (including DTA) has been signed by all contributing members. The collaboration is multi-disciplinary, involving epidemiologists, geneticists, nutritionists, biologists and clinicians.
Start Year 2019
 
Description NutriPROGRAM consortium collaboration 
Organisation University of British Columbia
Country Canada 
Sector Academic/University 
PI Contribution We co-designed and lead work package 4 in the Nutriprogram consortium project. We also lead or contribute to several other activities in other work packages.
Collaborator Contribution Other partners lead other work packages and contribute data and results to the work package we lead (WP4).
Impact A collaboration agreement (including DTA) has been signed by all contributing members. The collaboration is multi-disciplinary, involving epidemiologists, geneticists, nutritionists, biologists and clinicians.
Start Year 2019
 
Description NutriPROGRAM consortium collaboration 
Organisation Wageningen University & Research
Country Netherlands 
Sector Academic/University 
PI Contribution We co-designed and lead work package 4 in the Nutriprogram consortium project. We also lead or contribute to several other activities in other work packages.
Collaborator Contribution Other partners lead other work packages and contribute data and results to the work package we lead (WP4).
Impact A collaboration agreement (including DTA) has been signed by all contributing members. The collaboration is multi-disciplinary, involving epidemiologists, geneticists, nutritionists, biologists and clinicians.
Start Year 2019
 
Description PURE-South Africa 
Organisation North-West University
Country South Africa 
Sector Academic/University 
PI Contribution Dr Hannah Elliott; This collaboration is concerned with capacity building in epigenetic epidemiology in S Africa. Focused on a joint project comparing epigenetic signatures in rural and urban dwelling individuals. Dr Elliott has co-supervised a PhD student based at North-West University. My research team had contributed through the provision of advice on study design, samples processing and data generation at the University of Bristol, training in data analysis, support in drafting outputs.
Collaborator Contribution Intellectual contributions, sample provision, some funding for sample analysis.
Impact Cronjé, HT, Nienaber-Rousseau, C, Min, JL, Green, FR, Elliott HR & Pieters, M, 2021, "Comparison of DNA methylation clocks in Black South African men", Epigenomics. (accepted) Cronjé, HT, Elliott, HR, Nienaber-Rousseau, C, Green, F, Schutte, A & Pieters, M 2020, 'Methylation vs protein inflammatory biomarkers and their associations with cardiovascular function', Frontiers in Immunology, vol. 11, 1577. https://doi.org/10.3389/fimmu.2020.01577 PMID: 32849535 Cronjé, HT, Elliott, HR, Nienaber-Rousseau, C & Pieters, M 2020, 'Leveraging the urban-rural divide for epigenetic research', Epigenomics. https://doi.org/10.2217/epi-2020-0049 PMID: 32657149 Cronjé, HT, Elliott, HR, Nienaber-Rousseau, C & Pieters, M 2020, 'Replication and expansion of epigenome-wide association literature in a black South African population', Clinical Epigenetics, vol. 12, 6 (2020). https://doi.org/10.1186/s13148-019-0805-z PMID: 31910897
Start Year 2018
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Center for Environmental Research and Children's Health
Department The CHAMACOS Study
Country United States 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Columbia Center for Children's Environmental Health
Country United States 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation European Association for Research on Learning and Instruction (EARLI)
Country Belgium 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation European Huntington's Disease Network (Euro-HD)
Country Germany 
Sector Charity/Non Profit 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Federal Ministry for the Environment, Nature Conservation and Nuclear Safety (BMU)
Department International Climate Initiative (ICI)
Country Germany 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Finnish Birth Cohort
Country Finland 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation GECKO Drenthe Birth Cohort
Country Netherlands 
Sector Hospitals 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation GenExp
Country United Kingdom 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation GenR
Country United States 
Sector Charity/Non Profit 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Glyndwr University
Country United Kingdom 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Government of Canada
Department Aboriginal Affairs and Northern Development
Country Canada 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation ITS United Kingdom
Country United Kingdom 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Inmarsat
Country United Kingdom 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation MTT Ltd Machine Tools Technologies
Country United Kingdom 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation National Institute of Environmental Health Sciences
Department Norway Facial Clefts Study (NCL)
Country United States 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation National Institute of Standards & Technology (NIST)
Country United States 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation National Institutes of Health (NIH)
Department National Heart, Lung, and Blood Institute (NHLBI)
Country United States 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation New Hampshire Birth Cohort Study
Country United States 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation PRISMA ONG
Country Peru 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Progressive Energy Ltd
Country United Kingdom 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Project Viva
Country United States 
Sector Charity/Non Profit 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Rhode Island Child Health Study
Sector Charity/Non Profit 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Rutherford Appleton Laboratory
Department Space Science and Technology Department
Country United Kingdom 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation University of Bristol
Department Avon Longitudinal Study of Parents and Children (ALSPAC)
Country United Kingdom 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation University of Cambridge
Department PomBase
Country United Kingdom 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation University of Western Australia
Department Raine Medical Research Foundation
Country Australia 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation VCE Mobile & Personal Comm Ltd
Country United Kingdom 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Public Health Foundation India 
Organisation Public Health Foundation of India
Country India 
Sector Public 
PI Contribution I supervise a PHFI Postdoctoral Fellow, Dr Gagandeep Kaur Walia. I regularly host this fellow in my research group and provide ad hoc research support and advice to her.
Collaborator Contribution Cultural diversity and the opportunity to collaborate with Indian cohort studies.
Impact Kaur Walia G. Public Health Foundation of India-UK Joint Fellowship. Jul 2015-Jun2017. Supervisor. Gupta V, Saxena R, Walia GK, Aggarawal T, Dunn WB, Relton CL, Sovio U, Papegeorghiou A, Davey Smith G, Khadgawal R, Sachdeva MP. Gestational route to healthy birth (GaRBH): protocol for an Indian prospective cohort study. BMJ Open. 2019 May 1;9(4):e025395. doi: 10.1136/bmjopen-2018-025395. PMID:31048433. Agarwal T, Lyngdoh T, Dudbridge F, Chandak GR, Sinra S, Prabhakaran D, Reddy KS, Relton CL, Davey Smith G, Ebrahim S, Gupta V, Walia GK. Causal relationships between lipid and glycaemic traits in an Indian population: A bidirectional Mendelian randomization approach. PLoS One. 2020 Jan 29;15(1):e0228269. Doi: 10.1371/journal.pone.0228269. eCollection 2020. PMID:31995593.
Start Year 2013
 
Description Roswell Park 
Organisation University at Buffalo
Department Roswell Park Cancer Institute
Country United States 
Sector Academic/University 
PI Contribution Dr Rebecca Richmond; We shared a protocol for obtaining saliva samples from study participants which we will use to assess DNA methylation changes. We have also provided saliva kits for the samples to be collected.
Collaborator Contribution Roswell Park has been collecting saliva samples from their study assessing e-cigarette use which we will later use to investigate DNA methylation changes.
Impact None yet
Start Year 2019
 
Description SABRE 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration in epigenetics research identifying ethnic differences in DNA methylation and associations between DNA methylation and cardiovascular disease and type 2 diabetes.
Collaborator Contribution Provision of DNA samples and genetic data, intellectual input
Impact 10.1038/s41588-021-00923-x 10.1371/journal.pone.0227728 10.1186/1868-7083-6-4 10.1093/ije/dyv010
Start Year 2013
 
Description Silver - LSHTM 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Sharing of epigenetic epidemiology expertise Support for causal inference analyses. Replication studies.
Collaborator Contribution Sharing of epigenetic epidemiology expertise. Replication studies.
Impact Combined analysis in progress
Start Year 2021
 
Description The HUNT study (Norwegian University of Science and Technology) 
Organisation Norwegian University of Science and Technology (NTNU)
Country Norway 
Sector Academic/University 
PI Contribution Aim is to investigate ability of DNA methylation to capture variation in serum protein abundance variation.
Collaborator Contribution Knowledge and experience with omic data, lab for DNA methylation generation
Impact None yet
Start Year 2020
 
Description Thirlwell (University of Exeter) 
Organisation University of Exeter
Country United Kingdom 
Sector Academic/University 
PI Contribution Prof C Relton & Dr Matt Suderman; Epigenetic epidemiology expertise. Clinical knowledge, multi-omic tumor profile datasets and potential for further data capture. Aim is to better understand and predict outcomes of neuroendocrine tumors using multi-omic tumor profiles.
Collaborator Contribution Machine learning tools and knowledge and experience with omic data.
Impact Poster presentation at the 19th Annual ENETS Conference (Mar 10-11, 2022)
Start Year 2020
 
Description UFPel 
Organisation Federal University of Pelotas (UFPel)
Country Brazil 
Sector Academic/University 
PI Contribution Epigenetic epidemiology expertise. Training provision (hosting of visiting researchers and delivery of training in Brazil) Contribution to co-supervision of a PhD student
Collaborator Contribution Access to unique Brazilian birth cohorts. Maternal and perinatal epidemiology
Impact Relton CL, Hartwig FP Davey Smith G. From stem cells to the law courts: DNA methylation, the forensic epigenome and the possibility of a biosocial archive. Int J Epidemiol 2015 44 (4): 1083-1093. doi: 10.1093/ije/dyv198 Genomics, Epigenomics and Causal Inference in Population Health, Federal University of Pelotas, Brazil, March 2015
Start Year 2013
 
Description UK Biobank Sleep Working Group 
Organisation Harvard University
Country United States 
Sector Academic/University 
PI Contribution Dr Rebecca Richmond; Ccontributed data analysis to consortium projects, writing and critical evaluation of manuscripts
Collaborator Contribution Rebecca Richmond contributed data analysis to consortium projects, writing and critical evaluation of manuscripts
Impact Lane JM, Jones S, Dashti H, Wood A, Aragam K, van Hees VT, Brumpton B, Wisvold BS, Wang H, Bowden J, Song T, Patel K, Anderson SG, Beaumont R, Bechtold DA, Cade B, Kathiresan S, Little MA, Luik AI, Loudon AS, Purcell S, Richmond RC, et al. Biological and clinical insights from genetics of insomnia symptoms. Nature Genetics, 2018 https://doi.org/10.1038/s41588-019-0361-7 Wang H, Lane JM, Jones SE, Dashti H, Ollila H, Wood AR, van Hees VT, Brumpton B, Winsvold BS, Kantojarvi K, Cade BE, Sofer T, Song Y, Patel K, Anderson SG, Bechtold DA, Bowden J, Emsley R, Kyle SD, Little MA, Loudon AS, Scheer AJL, Purcell SM, Richmond RC, et al. Genome-wide association analysis of excessive daytime sleepiness identified 42 loci that suggest phenotypic subgroups. Nature Communications 2019; 10.1038/s41467-019-11456-7 Richmond RC, Anderson EL, Dashti HS et al. Investigating causal relations between sleep traits and risk of breast cancer in women: a Mendelian randomization study. British Medical Journal, 2019 Liu J*, Richmond RC*, Bowden J, Barry C, Dashti HS, Daghlas I, Lane JM, Jones SE, Wood AR, Frayling TM, Wright AK, Carr MJ, Anderson SG, Emsley R, Ray D, Weedon MN, Saxena R, Lawlor DA, Rutter MK. Assessing the causal role of sleep traits on glycated haemoglobin: a Mendelian randomization study. medRxiv https://doi.org/10.1101/2020.12.18.20224733 Daghlas I, Richmond RC, Dashti HS, Ollila H, Lane J, Schernhammer ES, Davey Smith G, Rutter MK, Saxena R, Vetter C. Mendelian randomization reveals a causal gradient of lower educational attainment and greater body mass index on selection into shift work. IJE 2021 Anderson EL, Richmond RC, Jones SE et al. Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis. IJE 2020
Start Year 2017
 
Description UK Biobank Sleep Working Group 
Organisation University of Exeter
Country United Kingdom 
Sector Academic/University 
PI Contribution Dr Rebecca Richmond; Ccontributed data analysis to consortium projects, writing and critical evaluation of manuscripts
Collaborator Contribution Rebecca Richmond contributed data analysis to consortium projects, writing and critical evaluation of manuscripts
Impact Lane JM, Jones S, Dashti H, Wood A, Aragam K, van Hees VT, Brumpton B, Wisvold BS, Wang H, Bowden J, Song T, Patel K, Anderson SG, Beaumont R, Bechtold DA, Cade B, Kathiresan S, Little MA, Luik AI, Loudon AS, Purcell S, Richmond RC, et al. Biological and clinical insights from genetics of insomnia symptoms. Nature Genetics, 2018 https://doi.org/10.1038/s41588-019-0361-7 Wang H, Lane JM, Jones SE, Dashti H, Ollila H, Wood AR, van Hees VT, Brumpton B, Winsvold BS, Kantojarvi K, Cade BE, Sofer T, Song Y, Patel K, Anderson SG, Bechtold DA, Bowden J, Emsley R, Kyle SD, Little MA, Loudon AS, Scheer AJL, Purcell SM, Richmond RC, et al. Genome-wide association analysis of excessive daytime sleepiness identified 42 loci that suggest phenotypic subgroups. Nature Communications 2019; 10.1038/s41467-019-11456-7 Richmond RC, Anderson EL, Dashti HS et al. Investigating causal relations between sleep traits and risk of breast cancer in women: a Mendelian randomization study. British Medical Journal, 2019 Liu J*, Richmond RC*, Bowden J, Barry C, Dashti HS, Daghlas I, Lane JM, Jones SE, Wood AR, Frayling TM, Wright AK, Carr MJ, Anderson SG, Emsley R, Ray D, Weedon MN, Saxena R, Lawlor DA, Rutter MK. Assessing the causal role of sleep traits on glycated haemoglobin: a Mendelian randomization study. medRxiv https://doi.org/10.1101/2020.12.18.20224733 Daghlas I, Richmond RC, Dashti HS, Ollila H, Lane J, Schernhammer ES, Davey Smith G, Rutter MK, Saxena R, Vetter C. Mendelian randomization reveals a causal gradient of lower educational attainment and greater body mass index on selection into shift work. IJE 2021 Anderson EL, Richmond RC, Jones SE et al. Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis. IJE 2020
Start Year 2017
 
Description UK Biobank Sleep Working Group 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution Dr Rebecca Richmond; Ccontributed data analysis to consortium projects, writing and critical evaluation of manuscripts
Collaborator Contribution Rebecca Richmond contributed data analysis to consortium projects, writing and critical evaluation of manuscripts
Impact Lane JM, Jones S, Dashti H, Wood A, Aragam K, van Hees VT, Brumpton B, Wisvold BS, Wang H, Bowden J, Song T, Patel K, Anderson SG, Beaumont R, Bechtold DA, Cade B, Kathiresan S, Little MA, Luik AI, Loudon AS, Purcell S, Richmond RC, et al. Biological and clinical insights from genetics of insomnia symptoms. Nature Genetics, 2018 https://doi.org/10.1038/s41588-019-0361-7 Wang H, Lane JM, Jones SE, Dashti H, Ollila H, Wood AR, van Hees VT, Brumpton B, Winsvold BS, Kantojarvi K, Cade BE, Sofer T, Song Y, Patel K, Anderson SG, Bechtold DA, Bowden J, Emsley R, Kyle SD, Little MA, Loudon AS, Scheer AJL, Purcell SM, Richmond RC, et al. Genome-wide association analysis of excessive daytime sleepiness identified 42 loci that suggest phenotypic subgroups. Nature Communications 2019; 10.1038/s41467-019-11456-7 Richmond RC, Anderson EL, Dashti HS et al. Investigating causal relations between sleep traits and risk of breast cancer in women: a Mendelian randomization study. British Medical Journal, 2019 Liu J*, Richmond RC*, Bowden J, Barry C, Dashti HS, Daghlas I, Lane JM, Jones SE, Wood AR, Frayling TM, Wright AK, Carr MJ, Anderson SG, Emsley R, Ray D, Weedon MN, Saxena R, Lawlor DA, Rutter MK. Assessing the causal role of sleep traits on glycated haemoglobin: a Mendelian randomization study. medRxiv https://doi.org/10.1101/2020.12.18.20224733 Daghlas I, Richmond RC, Dashti HS, Ollila H, Lane J, Schernhammer ES, Davey Smith G, Rutter MK, Saxena R, Vetter C. Mendelian randomization reveals a causal gradient of lower educational attainment and greater body mass index on selection into shift work. IJE 2021 Anderson EL, Richmond RC, Jones SE et al. Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis. IJE 2020
Start Year 2017
 
Description UK10K consortium 
Organisation EMBL European Bioinformatics Institute (EMBL - EBI)
Country United Kingdom 
Sector Academic/University 
PI Contribution Dr Josine Min; Contribution of data and research from the University of Bristol
Collaborator Contribution Contribution of data and research from the University of Bristol
Impact The Iotchkova et al and Haworth et al. manuscripts are outputs from the UK10K consortium.
Start Year 2012
 
Description University of Exeter Medical School 
Organisation University of Exeter
Department Medical School
Country United Kingdom 
Sector Academic/University 
PI Contribution My team collaborates with genetic epidemiologists and epigeneticists at this institution. I am a collaborator on the Wellcome Trust Sir Henry Dale Felowship of Dr Rachel Freathy. I also bring epidemiological expertise to our collaboration with Prof Jonathan Mill, with whom we have obtained joint funding.
Collaborator Contribution Dr Freathy undertakes large scale genetic epidemiology and utilises samples from our studies. Prof Mill brings epigenetic expertise as well as tissue specific epigenetic studies. We collaborate with Prof Mills in the leadership of the genetics of DNA methylation Consortium (GoDMC).
Impact GW4 Initiator grant to establish a GW Epigenetics Consortium GW4 Accelerator grant (CRISPR/Cas) to pilot gene editing on epigenetic loci. Prof Mill is a co-PI on the Genetics of DNA Methylation Consortium
Start Year 2013
 
Description Welsh & Saleem (University of Bristol) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Aim is to investigate ability of 'omic profiles to predict response to treatment in nephrotic syndrome
Collaborator Contribution Knowledge and experience with omic data, lab for DNA methylation generation
Impact MRC PhD Fellowship (Samantha Hayward)
Start Year 2018
 
Description Zeggini (Munich) 
Organisation Technical University of Munich
Country Germany 
Sector Academic/University 
PI Contribution Partner- Specialised knowledge of osteoarthritis, clinical samples, omic profiles. Aim is to unravel the genomic architecture of osteoarthritis by investigating multi-omic profiles of knee cartilage and synovium of individuals with and without osteoarthritis.
Collaborator Contribution Knowledge and tools for analysing omic profiles. C Relton a member of the thesis committee of Peter Kreitmaier, a PhD student supervised by Prof Zeggini.
Impact A few conference presentations and manuscripts in preparation. Annual thesis committee reports. This collaboration is multi-disciplinary involving rheumatology, human genetics, bioinformatics and population health/epidemiology
Start Year 2019
 
Title Dmrff 
Description Identifies associations in genome-wide DNA methylation datasets with improved power while controlling error rates 
Type Of Technology Software 
Year Produced 2019 
Open Source License? Yes  
Impact Used to analyse data in 14 published studies 
URL https://github.com/perishky/dmrff
 
Title EWAS Catalog 
Description This webtool/application has curated all published epigenome-wide association studies (EWAS) (using the Illumina BeadChip platform) and incorporated them in to a searchable data base. This allows the user to locate any variable methylation probes they may be interested in in a similar way to the GWAS catalog for genetic variants. It provides a centralised repository and search tool for any investigator interested in EWAS. 
Type Of Technology Webtool/Application 
Year Produced 2018 
Open Source License? Yes  
Impact The web application has just been released. It should have considerable impact across the research community as a browsing facility for all documented EWAS that appear in the published literature. 
URL http://www.ewascatalog.org
 
Description Co-coordinator and lecturer on Swiss Epidemiology Winter School in 2019 - R.Richmond 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Rebecca Richmond presented a lecture to 20 Epidemiology students and researchers at the Swiss Epidemiology Winter School in 2019, this sparked discussions for future collaborations.
Year(s) Of Engagement Activity 2019
 
Description APPG Medical Research 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact All Party Parliamentary Group on Medical Research
Year(s) Of Engagement Activity 2022
 
Description Academy of Medical Sciences "Inspire" Showcase (Rebecca Richmond) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Undergraduate students
Results and Impact Zoom lecture on molecular epidemiological research given to a representation of ~30 medical, dental and veterinary students in GW4 universities
Year(s) Of Engagement Activity 2021
 
Description Bristol Covid-19 Health Protection Advisory Group 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact This multidisciplinary group of experts met monthly throughout the pandemic to assist the City Council in dispensing its public health duties.
Year(s) Of Engagement Activity 2020,2021,2022
 
Description Building biosample based prospective cohorts in India 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This workshop aimed to catalyse the creation and future application of a large population-based study in India. There has been continued involvement, inclusding the submission of related funding applications and the awarding of research funds to undertake an indoor air pollution study.
Year(s) Of Engagement Activity 2019
 
Description COVID, education and schools 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Dr sarah Lewis has authored a series of blogs on issues around the impact of COVID-19 in the educational sector. These have included the perceived risk of schools opening and the risk of mortality in teachers compared to other professions.
Year(s) Of Engagement Activity 2020,2021
URL https://ieureka.blogs.bristol.ac.uk/2020/12/15/covid19-should-schools-close-early-for-christmas/
 
Description Citizen Science Project - R.Richmond 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Rebecca Richmond has been involved in a Citizen Science project taking place as part of the SPHERE initiative which has involved engaging and working with members of the project as part of a participant-led research project around sleep.
Year(s) Of Engagement Activity 2018
 
Description Creative Reactions 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact I took part in Creative Reactions, an initiative that pairs scientists with artists to create artwork based on their academic research. I was paired with Olga Trevisan, an artist based in Venice, Italy. Based on some of my research around the Developmental Origins of Health and Disease, Olga created a piece called Beyond Question, which comments on the complexities of scientific data collection, bias and interpretation. Interesting conversations with people viewing the artwork revealed that some people's opinions (about the importance of the maternal contribution to offspring health, relative to paternal and wider societal influences) were challenged and changed. The artwork was displayed at two exhibitions at different sites in Bristol, with two separate launch events attended by the local media.
Year(s) Of Engagement Activity 2019
URL https://epoch.blogs.bristol.ac.uk/2019/12/21/beyond-question-a-collaboration-between-epoch-and-artis...
 
Description Curriculum enhancement materials for Key stages 3,4 and 5 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact We developed a suite of curriculum enhancement materials (lesson plans and resources) based on COVID-19 for use by the schools involved in the CoMMinS study as well as any other school wishing to access these resources. The materials were developed through collaboration with an eductaional charity (IRIS)
Year(s) Of Engagement Activity 2021
URL https://commins.org.uk/school_staff/
 
Description Department for Education 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact We have established links with the Department for Education with whom we are discussing research priorities. The aim of this engagement is to ensure future research plans for CoMMInS are closely aligned with those of the DfE and therefore have potential for rapid policy translation.
Year(s) Of Engagement Activity 2021
 
Description EMBL-EBI Human Ecosystems Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The event was aimed at developing and discussing input to the quinquennial EMBL-EBI strategic vision
Year(s) Of Engagement Activity 2020
 
Description Education in our genes 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This one day workshop was aimed at both social and biomedical scientists to present current developments around the application of genetic and epigenetic data in relation the educational attainment and related characteristics
Year(s) Of Engagement Activity 2017
 
Description Embracing epigenetics in epidemiological studies 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact A webinar covering various approaches to study design and data analysis in epigenetic epidemiology. The webinar sought to communicate areas of expertise and consolidate future collaborative activity with the Million Veterans Programme (Boston, USA).
Year(s) Of Engagement Activity 2019
 
Description Epigenetic Clock Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A one day workshop was held to present and discuss approaches to research using the epigenetic clock as a biomarker of biological age.
Year(s) Of Engagement Activity 2017
 
Description Epigenetics in Neuroscience and Psychiatry 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact An invited talk at a one day workshop
Year(s) Of Engagement Activity 2019
 
Description Epigenomics and disease prediction 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact An invited talk at a symposium
Year(s) Of Engagement Activity 2020
 
Description Epigenomics of Common Diseases Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited speaker: Epigenomics of Common Disease Conference, Hinxton, Cambridge, UK. Nov 2021
Year(s) Of Engagement Activity 2021
 
Description Fun Palaces event planning - Rebecca Richmond 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Rebecca Richmond (ICEP Researcher) helped to organise a public engagement event relating to her e-cigarette study which was at Fun Palaces in Bristol in October 2017. Fun Palaces initiative is where community organisations lead events to connect public members with scientific research through creative interests or hobbies and expertise that may sit within those communities. The event allowed knowledge exchange between researchers and the public, informing about the demographic of e-cigarette use.
Year(s) Of Engagement Activity 2017
 
Description Greenman - R.Richmond 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Rebecca Richmond helped to organize and implement several public engagement activities in the "Einstein's Garden" of the Green Man Festival in 2018. More than 500 people attended.
Year(s) Of Engagement Activity 2018
 
Description IGES conference - J.Staley 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact James Staley presented a conference poster to 250 people at the IGES Conference in San Diego, on the 18th October 2018. The poster/presentation is entitled: Longitudinal strategies for identifying genetic associations with epigenetic changes over time
Year(s) Of Engagement Activity 2018
 
Description Inaugural Researchers' Summit for the new India-UK Cancer Research Initiative - C Relton 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Caroline Relton (ICEP PI) was invited to attend the Inaugural Researchers' Summit for the new India-UK Cancer Research Initiative, a joint venture between Cancer Research UK and the Indian Government's Department of Biotechnology (DBT). This initiative seeks to establish new bilateral research alliances to undertake impactful research and develop innovative approaches to improving cancer outcomes. The Summit took place in New Delhi, India in November 2018 and brought together leading researchers, clinicians and technologists to identify the core research challenges under the broad theme of affordable approaches to cancer.
Year(s) Of Engagement Activity 2018
 
Description Inserm-EMBL 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited speaker at Inserm-EMBL: 'Connecting molecular biology and epidemiology to study the exposome' Workshop. Paris, France Sep 2021
White paper on the role of the exposome as an environmental sensor is in preparation.
Year(s) Of Engagement Activity 2021
 
Description Meetings with MP 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A series of meetings have been help with Thangam Debbonaire (MP, Bristol West) to discuss issues pertaining to the CoMMinS study. Advice was provided on stdy recruitment and contemprary issues around school closures and COVID-secure educational provision discussed. Information was shared with other constituency MPs in the city.
Year(s) Of Engagement Activity 2020,2021
 
Description Molecular Epidemiology Group Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Annual scientific meeting of a multi-disciplinary academic group of international researchers
Year(s) Of Engagement Activity 2019
 
Description New Horizons in Genomics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited talk at a symposium.
Year(s) Of Engagement Activity 2019
 
Description NutriPROGRAM Twitter 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact We have a NutriPROGRAM Twitter account with nearly 50 followers.
Year(s) Of Engagement Activity 2019
URL https://twitter.com/nutriprogram
 
Description Organize and lead the Science Focus Lab for Compass (University of Bristol EPSRC Centre for Doctoral Training in Computational Statistics and Data Science- M Suderman, P Yousefi, J Min 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Suderman, Yousefi and Min curated a dataset and wrote and presented a project proposal related to PhD students in the COMPASS programme. During the following two weeks, the students worked on the projects. At the end, the students presented and discussed their results with Suderman and Yousefi.
Year(s) Of Engagement Activity 2021
URL https://www.bristol.ac.uk/cdt/compass
 
Description Presentation at Nutrition Symposium, Erasmus - C Relton 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Caroline Relton was invited to present at Nutrition Symposium, Erasmus Medical Center in June 2018. Prof Relton presented: Causal analysis in epigenetic epidemiology. The talk prompted the following exchange of letters: http://advances.sciencemag.org/content/4/1/eaao4364/tab-e-letters. The talk also raised the profile of Prof Relton and her research.
Year(s) Of Engagement Activity 2018
URL http://advances.sciencemag.org/content/4/1/eaao4364/tab-e-letters
 
Description Presentation at SER Annual Meeting (USA) - R Richmond 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Dr Rebecca Richmond was invited to give a talk at the Society for Epidemiologic Research (SER) annual meeting in Minneapolis, USA in June 2019. The presentation was entitled: Using Mendelian Randomization to understand how chronotype influences breast cancer risk. This talk raised the profile of Dr Richmond and her research.
Year(s) Of Engagement Activity 2019
 
Description Presentation at UCLA - R Richmond 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Dr Rebecca Richmond was invited to give a talk at the Department of Human Genetics Seminar Series, UCLA in Los Angeles, USA in September 2019. The presentation was entitled: Investigating the mediating role of molecular mechanisms in common complex disease using epidemiological tools. This talk raised the profile of Dr Richmond and her research.
Year(s) Of Engagement Activity 2019
 
Description Presentation at Ulster University - R Richmond 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Dr Rebecca Richmond was invited to give a talk at the Epigenetics in Health and Wellbeing Workshop at Ulster University, Northern Ireland in April 2019. The presentation was entitled: Epigenetics and Lifecourse Epidemiology. This talk raised the profile of Dr Richmond and her research.
Year(s) Of Engagement Activity 2019
 
Description Presentation at University of Edinburgh - R Richmond 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Dr Rebecca Richmond was invited to give a talk at the Division of Psychiatry Seminar Series, University of Edinburgh in August 2019. The presentation was entitled: Smoking, DNA methylation and lung function: A Mendelian randomization analysis to investigate causal relationships. This talk raised the profile of Dr Richmond and her research.
Year(s) Of Engagement Activity 2019
 
Description Presented 'Longitudinal DNA methylation and other omics in ALSPAC' to the virtual Illumina Users Group meeting (Mar 15, 2022) - Suderman 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Suderman presented what has been learned from omic data in ALSPAC and potential for further analyses. The presentation was followed by discussion with the audience.
Year(s) Of Engagement Activity 2022
 
Description Richard Doll Seminar in Public Health & Epidemiology (University of Oxford) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact A formal seminar. Additional collaborative activity arose following the visit.
Year(s) Of Engagement Activity 2019
 
Description Statistics in Epigenetics Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A one day workshop was held to describe and discuss recent key statistical advances for analysing DNA methylation data funded by an MRC grant. A keynote lecture was also given on the 'Estimation of a significance threshold for epigenome-wide association studies'. Over 60 post-grad students, fellow researchers, and health professionals attended this free workshop.
Year(s) Of Engagement Activity 2018
URL https://www.eventbrite.co.uk/e/epigenetics-statistics-workshop-tickets-49889050493
 
Description The Cell's Cancer Short course event, University of Bristol, March 2021 (Rebecca Richmond) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Zoom lecture on molecular epidemiological research in cancer given to "The Cell", a representation of ~30 students studying Cellular and Molecular Medicine at the University of Bristol.
Year(s) Of Engagement Activity 2021
 
Description UK Clock Club: Virtual Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Virtual conference attended by >100 sleep and circadian biology researchers
Year(s) Of Engagement Activity 2020
 
Description Using omics in causal inference - Gilead, Verge Genomics, 23 & Me, Calico Labs 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact The aim of this series of seminars and visits to various pharma and biotech companies was to promote our research activities and pursue collaborative opportunities.
Year(s) Of Engagement Activity 2019
 
Description Visit to Barshi, India - C Relton 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Professors Caroline Relton and George Davey Smith went to Barshi, India in May 2018. They visited the India Study for Health of Adults (Barshi Cohort Study) in action and the TATA Memorial Centre. Their trip included presenting to villages who were cohort participants and visiting the field site of the Barshi cohort. Future collaborations between Bristol and the TATA team were discussed.
Year(s) Of Engagement Activity 2018
 
Description Wellcome Training Workshop at OUCRU - C Relton 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Prof Caroline Relton (ICEP PI) visited OUCRU (Oxford University Clinical Research Unit) in Ho Chi Minh City and Hanoi, Vietnam for a week in April 2018. The workshops were set up by the Wellcome Trust, where Prof Relton delivered training in group leadership, the process of peer review, grant writing and career development to Wellcome-funded researchers of all stages based there.
Year(s) Of Engagement Activity 2018
 
Description Workshop on Osteoporosis Functional Genomics 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Workshop on Osteoporosis Functional Genomics, organised by the Osteoporosis and Bone research Academy of the Royal Osteoporosis Society.
Year(s) Of Engagement Activity 2020