Epigenetic Epidemiology
Lead Research Organisation:
University of Bristol
Abstract
This programme aims to gain a better understanding of the determinants and consequences of epigenetic variation through the use of epidemiological approaches. We will extend our knowledge of the relationship between common genetic variation and DNA methylation across the genome through large scale GWAS analysis. The identification of genetic variants that tag methylation variation will enhance our ability to conduct Mendelian randomization to strengthen causal inference. We will develop our use of DNA methylation as a biomarker of disease prediction and prognosis as well as an index of exposure to disease risk factors. Lastly, we will combine these elements of the programme and other methodological advances in epigenetic epidemiology to address a variety of disease specific research questions.
Technical Summary
Background: To maximally exploit the rapid pace of change, including the accrual of large-scale data, in the field of epigenetic epidemiology, we will develop innovative methods for the robust scientific interrogation of population-based epigenetic data and apply them to research questions of scientific and medical importance, structured around four domains:
Aim 1: We will explore the genetic architecture of epigenetic traits and use this information to understand the role that DNA methylation variation plays in health and disease.
Aim 2: We will develop and make readily accessible the causal analysis methods and tools and apply Mendelian randomization (MR) to epigenetic questions.
Aim 3: We will use DNA methylation as an index of past exposures to improve our prediction of disease risk and prognosis.
Aim 4: From neurodevelopment to cancer, there are a multitude of settings in which we can apply epigenetic epidemiology to understand disease mechanisms and predict disease.
Methods: We will utilize multiple data sources; from in-house studies, via collaborations and consortia, and through publicly accessible repositories. Our primary focus will be on the analysis of DNA methylation, as this continues to be the most readily available source of epigenetic data in population-based studies. However, we will integrate these data with newly generated and publicly available epigenomic and transcriptomic data, tissue-specific data and histone modification data.
A wide range of methods will be applied. These include mQTL analysis, functional annotation and machine learning approaches, such as penalized regression, support vector machines, and neural networks. We will test for mediation using MR and apply our prediction methods in disease relevant datasets.
Translation: The output arising from this programme will be used to develop biomarkers of disease risk and disease prognosis. It will also shed light on the genetic architecture of DNA methylation and the causal role this molecular phenotype plays in development and disease, which will in turn inform future interventions.
Aim 1: We will explore the genetic architecture of epigenetic traits and use this information to understand the role that DNA methylation variation plays in health and disease.
Aim 2: We will develop and make readily accessible the causal analysis methods and tools and apply Mendelian randomization (MR) to epigenetic questions.
Aim 3: We will use DNA methylation as an index of past exposures to improve our prediction of disease risk and prognosis.
Aim 4: From neurodevelopment to cancer, there are a multitude of settings in which we can apply epigenetic epidemiology to understand disease mechanisms and predict disease.
Methods: We will utilize multiple data sources; from in-house studies, via collaborations and consortia, and through publicly accessible repositories. Our primary focus will be on the analysis of DNA methylation, as this continues to be the most readily available source of epigenetic data in population-based studies. However, we will integrate these data with newly generated and publicly available epigenomic and transcriptomic data, tissue-specific data and histone modification data.
A wide range of methods will be applied. These include mQTL analysis, functional annotation and machine learning approaches, such as penalized regression, support vector machines, and neural networks. We will test for mediation using MR and apply our prediction methods in disease relevant datasets.
Translation: The output arising from this programme will be used to develop biomarkers of disease risk and disease prognosis. It will also shed light on the genetic architecture of DNA methylation and the causal role this molecular phenotype plays in development and disease, which will in turn inform future interventions.
Organisations
- University of Bristol, United Kingdom (Collaboration, Lead Research Organisation)
- Barcelona Institute for Global Health (Collaboration)
- Columbia University, United States (Collaboration)
- University College Dublin, Ireland (Collaboration)
- Biogen Idec (Collaboration)
- Harvard University (Collaboration)
- Federal University of Pelotas (Collaboration)
- University of Toronto (Collaboration)
- University of Cambridge (Collaboration)
- European Huntington's Disease Network (Euro-HD) (Collaboration)
- Rhode Island Child Health Study (Collaboration)
- Austrian Academy of Sciences (Collaboration)
- Glyndwr University, United Kingdom (Collaboration)
- University of British Columbia, Canada (Collaboration)
- Norwegian Institute of Public Health (Collaboration)
- Leiden University Medical Center (Collaboration)
- Federal Ministry for the Environment, Nature Conservation and Nuclear Safety (BMU) (Collaboration)
- MTT Ltd Machine Tools Technologies (Collaboration)
- Ludwig Maximilians University Munich (Collaboration)
- University of Exeter, United Kingdom (Collaboration)
- VCE Mobile & Personal Comm Ltd, United Kingdom (Collaboration)
- Aircraft Research Association Limited, BEDS (Collaboration)
- International Agency for Research on Cancer (IARC) (Collaboration)
- Erasmus MC (Collaboration)
- GECKO Drenthe Birth Cohort (Collaboration)
- King's College London, United Kingdom (Collaboration)
- University of Western Australia, Australia (Collaboration)
- EMBL - European Bioinformatics Institute, United Kingdom (Collaboration)
- University of Southampton, United Kingdom (Collaboration)
- University College London, United Kingdom (Collaboration)
- European Association for Research on Learning and Instruction (EARLI) (Collaboration)
- North West University, South Africa (Collaboration)
- GenR (Collaboration)
- University of Bath, Bath (Collaboration)
- Public Health Foundation of India (Collaboration)
- Wageningen University & Research (Collaboration)
- Cardiff University, United Kingdom (Collaboration)
- Rutherford Appleton Laboratory, Oxford (Collaboration)
- Center for Environmental Research and Children's Health (Collaboration)
- National Institute of Standards & Technology (NIST) (Collaboration)
- National Heart, Lung, and Blood Institute (NHLBI) (Collaboration)
- University of Queensland, Australia (Collaboration)
- Finnish Birth Cohort (Collaboration)
- Sanofi (Collaboration)
- Government of Canada (Collaboration)
- Columbia Center for Children's Environmental Health (Collaboration)
- Progressive Energy Ltd (Collaboration)
- PRISMA ONG (Collaboration)
- Medical Research Council (Collaboration)
- Memphis University (Collaboration)
- Copenhagen University Hospital (Collaboration)
- National Institute of Environmental Health Sciences (Collaboration)
- Project Viva (Collaboration)
- GenExp (Collaboration)
- ITS United Kingdom (Collaboration)
- New Hampshire Birth Cohort Study (Collaboration)
- Inmarsat (Collaboration)
People |
ORCID iD |
| Caroline Laura Relton (Principal Investigator) |
Publications
Bright HD
(2019)
Epigenetic gestational age and trajectories of weight and height during childhood: a prospective cohort study.
in Clinical epigenetics
Den Dekker HT
(2019)
Newborn DNA-methylation, childhood lung function, and the risks of asthma and COPD across the life course.
in The European respiratory journal
Reese SE
(2019)
Epigenome-wide meta-analysis of DNA methylation and childhood asthma.
in The Journal of allergy and clinical immunology
Taylor AE
(2019)
The effect of body mass index on smoking behaviour and nicotine metabolism: a Mendelian randomization study.
in Human molecular genetics
Huang J
(2019)
Circulating markers of cellular immune activation in prediagnostic blood sample and lung cancer risk in the Lung Cancer Cohort Consortium (LC3)
in International Journal of Cancer
Alfano R
(2019)
Socioeconomic position during pregnancy and DNA methylation signatures at three stages across early life: epigenome-wide association studies in the ALSPAC birth cohort
in International Journal of Epidemiology
Iotchkova V
(2019)
GARFIELD classifies disease-relevant genomic features through integration of functional annotations with association signals.
in Nature genetics
Perrier F
(2019)
Association of leukocyte DNA methylation changes with dietary folate and alcohol intake in the EPIC study.
in Clinical epigenetics
Wiklund P
(2019)
DNA methylation links prenatal smoking exposure to later life health outcomes in offspring.
in Clinical epigenetics
Sikdar S
(2019)
Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking.
in Epigenomics
Roberts S
(2019)
Longitudinal investigation of DNA methylation changes preceding adolescent psychotic experiences
in Translational Psychiatry
Shah UJ
(2019)
Differential methylation of the type 2 diabetes susceptibility locus KCNQ1 is associated with insulin sensitivity and is predicted by CpG site specific genetic variation.
in Diabetes research and clinical practice
Everson TM
(2019)
Epigenome-wide association study of asthma and wheeze characterizes loci within .
in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
Sharp GC
(2019)
Paternal impact on the life course development of obesity and type 2 diabetes in the offspring.
in Diabetologia
Phillips CM
(2019)
Dietary Inflammatory Index and Non-Communicable Disease Risk: A Narrative Review.
in Nutrients
Julvez J
(2019)
A Birth Cohort Study on the Genetic Modification of the Association of Prenatal Methylmercury With Child Cognitive Development.
in American journal of epidemiology
Zuo H
(2019)
Vitamin B6 catabolism and lung cancer risk: results from the Lung Cancer Cohort Consortium (LC3)
in Annals of Oncology
Wootton R
(2019)
Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: a Mendelian randomisation study
in Psychological Medicine
Odintsova VV
(2019)
DNA Methylation Signatures of Breastfeeding in Buccal Cells Collected in Mid-Childhood.
in Nutrients
Williams C
(2019)
Grandmothers' smoking in pregnancy is associated with a reduced prevalence of early-onset myopia.
in Scientific reports
Han L
(2019)
Changes in DNA methylation from pre- to post-adolescence are associated with pubertal exposures.
in Clinical epigenetics
Yousefi PD
(2019)
Validation and characterisation of a DNA methylation alcohol biomarker across the life course.
in Clinical epigenetics
Russell AE
(2019)
Pathways between early-life adversity and adolescent self-harm: the mediating role of inflammation in the Avon Longitudinal Study of Parents and Children.
in Journal of child psychology and psychiatry, and allied disciplines
Walton E
(2019)
Exploration of Shared Genetic Architecture Between Subcortical Brain Volumes and Anorexia Nervosa.
in Molecular neurobiology
| Description | 1001 Critical Days consultation |
| Geographic Reach | National |
| Policy Influence Type | Participation in a national consultation |
| URL | https://epoch.blogs.bristol.ac.uk/2020/02/04/the-1001-critical-days-movement/ |
| Description | Co-director of the MSc in Reproduction and Development |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Gemma Sharp is the co-director of the University of Bristol's highly successful MSc in Reproduction and Development. Students include practicing midwifes, junior doctors, researchers and embryologists. The course equips them with the necessary skills to improve their practice and critically appraise, design and conduct relevant research. |
| URL | http://www.bristol.ac.uk/medical-school/study/postgraduate/reproduction-development/ |
| Description | Genetic and Epigenetic Epidemiology (EEPE) course |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Gemma Sharp and Rebecca Richmond (along with David Evans and Gib Hemani) co-developed and delivered a one week course on genetic and epigenetic epidemiology in Florence. Participants ranged from masters to professorial level. The course was very well-received and participants reported feeling confident that they had achieved the intended learning outcomes. Several are now conducting their own genetic/epigenetic studies. |
| URL | https://eepe.org/courses/ |
| Description | Lectures at LSHTM |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Gemma Sharp was invited to give two lectures to masters students at the London School of Hygiene and Tropical Medicine: "Minimising bias and confounding in observational epidemiology" and "Mendelian Randomization". These will take place on March 17th 2020. The lectures are intended to introduce students to these important areas and methods in observational epidemiology and equip them with the skills to critically appraise, design and conduct high quality epidemiological research. |
| Description | MSc in Epidemiology - unit lead of 'Molecular Epidemiology for Noncommunicable Disease' |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Gemma Sharp co-developed from scratch and now co-delivers a unit on Molecular Epidemiology as part of the University of Bristol's MSc in Epidemiology. The unit introduces masters students to molecular (genetic and epigenetic) epidemiology and equips them with the skills to critically appraise, design and conduct high quality epidemiological research. |
| URL | https://www.bris.ac.uk/unit-programme-catalogue/UnitDetails.jsa;jsessionid=2BBAB6E8979AB5B406936FBF3... |
| Description | WRISK project expert panel - Gemma Sharp |
| Geographic Reach | National |
| Policy Influence Type | Participation in a advisory committee |
| URL | https://threadreaderapp.com/thread/1220645863577485312.html |
| Description | Workshop on harmonisation of data in multicohort studies |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Gemma Sharp gave a talk as part of a half-day course on data harmonization in observational studies at the DOHaD 2019 world congress in Melbourne. Participants ranged from masters to professorial level. The course was very well-received and participants reported feeling confident that they had achieved the intended learning outcomes. Several are now conducting their own multi cohort studies. |
| URL | http://www.cvent.com/events/2019-dohad-international/custom-132-828d23c3caf043c0ae6449de8d7bfbc3.asp... |
| Description | Workshop on triangulation |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Gemma Sharp co-developed and delivered a half-day course on triangulation in observational studies at the DOHaD 2019 world congress in Melbourne. Participants ranged from masters to professorial level. The course was very well-received and participants reported feeling confident that they had achieved the intended learning outcomes. Several are now conducting their own triangulation studies. |
| URL | http://www.cvent.com/events/2019-dohad-international/custom-132-828d23c3caf043c0ae6449de8d7bfbc3.asp... |
| Description | Creating a West African BioResource for Nutritional Genetics and Epigenetics (C Relton) |
| Amount | £186,171 (GBP) |
| Funding ID | MC_PC_MR/R020183/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 12/2018 |
| Description | De Pass Vice Chancellor's Fellowship - Rebecca Richmond |
| Amount | £260,000 (GBP) |
| Organisation | University of Bristol |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 10/2022 |
| Description | HDR UK RCUK Innovation/Rutherford Fellowships - Two fellowships (C Relton) |
| Amount | £614,457 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2018 |
| End | 01/2021 |
| Title | A web application for exploring tissue specific consequences of genetic variation |
| Description | This web application can be used to investigate associations between genome-wide gene expression and 395 complex traits by applying Mendelian randomization and genetic colocalization1. Analyses have been undertaken using gene expression derived from whole blood made available by the eQTLGen consortium2 (n=31,684), as well as 48 different tissue types from the GTEx project3. Findings from this web application can help uncover associations yet to be detected by genome-wide association studies and also investigate tissue-specific effects between gene expression and complex traits. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | The app has seen widespread use by the research community including non-academic partners. |
| URL | http://mrcieu.mrsoftware.org/molecular_MR_atlas |
| Title | Analysis package for identifying differentially methylation regions |
| Description | Statistical power in epigenome-wide association studies (EWAS) tends to be low due to the cost of generating genome-wide DNA methylation profiles. dmrff increases the power of EWAS by testing associations with DNA methylation measurements spread across regions rather than being limited to individual genomic loci. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | Widespread adoption as an analytical tool by the research community. |
| URL | https://github.com/perishky/dmrff |
| Title | GARFIELD - J.Min |
| Description | Josine Min has developed a novel approach that leverages genome-wide association studies' findings with regulatory or functional annotations to classify features relevant to a phenotype of interest. GARFIELD classifies disease-relevant genomic features through integration of functional annotations with association signals |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | This tool has been cited in at least 21 publications. |
| URL | https://www.ebi.ac.uk/birney-srv/GARFIELD/ |
| Title | Meffil - J.Min |
| Description | Josine Min and other researchers have developed a new tool for performing quality control and preprocessing large sets of DNA methylation profiles used in epidemiological studies. Previous tools were unable to process such large datasets without requiring high-end computational resources. Our tool may also be used to improve statistical power in meta-analyses. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | This package has been used to analyse 36 datasets from the GoDMC consortium. It has been cited by 20 publications. |
| URL | https://github.com/perishky/meffil#meffil |
| Title | EWAS Catalog |
| Description | A database of epigenome-wide association studies with seacrh tool |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | None as yet |
| URL | http://www.ewascatalog.org |
| Title | Genetics of DNA methylation Consortium (GoDMC) - Josine Min |
| Description | As part of the GoDMC (Genetics of DNA methylation Consortium) we have generated a database which contains all discovered mQTL associations. It also has a dalliance genome browser to explore regional features of the association. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | We have developed a github pipeline for the GoDMC consortium. So far, 36 different groups have processed and analysed their data and uploaded the results to our sftp server. |
| Title | Identification of differentially methylated regions |
| Description | This software tool improves on previous work by properly controlling false positive rates, providing support for meta-analysis and increasing statistical power |
| Type Of Material | Data analysis technique |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | None as yet |
| Description | ALPHABET |
| Organisation | University College Dublin |
| Department | School of Public Health, Physiotherapy and Population Science |
| Country | Ireland |
| Sector | Academic/University |
| PI Contribution | I am a co-investigator on a ERA-HDHL (BBSRC) collaborative research project on the influence of early life nutrition on offspring health led by UCD. Our contribution includes collating multi-centre epigenetic data, running epigenome-wide association studies, meta-analyses and causal analysis methods. |
| Collaborator Contribution | The partners in this collaboration contribute data from various large birth cohort studies and expertise in nutrition and other clinical disciplines |
| Impact | Aubert A, Forhan A, de Lauzon-Guillain B, Chen LW, Polanska K, Hanke W, Mensink-Bout SM, Duijts L, Suderman M, Relton CL, Crozier SR, Harvey NC, Cooper C, McAuliffe FM, Kelleher CC, Philips CM, Heude B, Bernard JY. Deriving the Dietary Approaches to stop Hypertension (DASH) score in women from seven pregnancy cohorts from the European ALPHABET consortium. Nutrients. 2019 Nov 8;11(11). pii: E2706. doi: 10.3390/nu11112706. PMID:31717283. |
| Start Year | 2017 |
| Description | Alcohol Exposure |
| Organisation | University of Toronto |
| Department | Baycrest Centre for Geriatric Care |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | Joint analysis of ALSPAC (epigenetic) data and imaging phenotypes obtained by Toronto group |
| Collaborator Contribution | Imaging phenotypes obtained by Toronto group |
| Impact | PhD thesis completed on the relationship between prenatal alcohol exposure, own alcohol use and neuroimaging phenotypes. |
| Start Year | 2016 |
| Description | Biogen Idec |
| Organisation | Biogen Idec |
| Department | MR and Epigenetics Industry Translation |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We have hosted and visited Biogen Idec to pursue collaborative links around discovery science in epigenetics. |
| Collaborator Contribution | Invitation to contribute to a Genomics Workshop at Biogen Idec and liaison regarding future collaboration |
| Impact | A collaborative agreement is being formulated. |
| Start Year | 2013 |
| Description | Columbia University, NY |
| Organisation | Columbia University |
| Department | Mental Health, Causal Epidemiology |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | My research team interact with Prof Ezra Susser at Columbia University on various aspects of epigenetics research. This involves face-to-face meetings, teleconferences and email correspondence. |
| Collaborator Contribution | Prof Susser brings expertise in epidemiology and psychiatry. |
| Impact | No specific outputs to record in this reporting period. Grant applications have been submitted but have not been successful. |
| Start Year | 2013 |
| Description | Copenhagen University |
| Organisation | Copenhagen University Hospital |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | We bring epigenetic epidemiology expertise. This collaboration is focused around the exploration of DNA methylation as an intermediate linking cigarette smoke exposure to a wide range of health outcomes. |
| Collaborator Contribution | The collaborators bring access to and biosamples from their very large population based resources, namely the Copenhagen City Heart Study |
| Impact | Manuscripts under submission and further papers are in preparation. |
| Start Year | 2013 |
| Description | ESRC Biomarker Data Project Fellowship in Understanding Society - R Richmond |
| Organisation | University of Essex |
| Department | Institute for Social and Economic Research, Essex |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data analysis of Understanding Society data. |
| Collaborator Contribution | Data provision for Understanding Society and mentorship. |
| Impact | Rebecca Richmond was awarded an ESRC fellowship. |
| Start Year | 2018 |
| Description | European Bioinformatics Institute |
| Organisation | EMBL European Bioinformatics Institute (EMBL - EBI) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We bring epidemiological and causal analysis expertise to this collaboration as well as generating epigenomic data for use by colleagues at EBI. |
| Collaborator Contribution | Bioinformatic expertise for the functional annotation of observed associations. |
| Impact | EBI have been involved in ARIES and have more recently been closely involved in formulating large strategic funding applications. The outputs of this work are too early to report. This is a multi-disciplinary collaboration between epidemiologists and bioinformaticians. |
| Start Year | 2013 |
| Description | GOYA Study Copenhagen |
| Organisation | Copenhagen University Hospital |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | We have generated epigenome-wide DNA methylation data on the GOYA cohort (a study of the offspring of extremely obese individuals) and have provided advice and analytical support in the use of these data. |
| Collaborator Contribution | The provision of biological samples for epigenetic profiling as well as associated data for analysis. Our collaborators also facilitate the acquisition of ethical permission to use the data for new analyses. |
| Impact | As a consequence of this collaboration GOYA is now part of the PACE study and features in various manuscripts that are currently in preparation led by my group. |
| Start Year | 2013 |
| Description | GW4 |
| Organisation | Cardiff University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The GW4 strategic alliance has established the GW4 Epigenetics Consortium which I instigated and brings complementary expertise from the 4 contributing Universitites together.We hosted a 2 day symposium and workshops and have subsequently secured and undertaken research activities around the use of CRISPR/Cas9 in epigenetics studies |
| Collaborator Contribution | 2 day symposium and workshops. Epidemiology expertise. |
| Impact | 2 day symposium and workshops. Further grant application to GW4 for research activities. This is a multi-disciplinary collaboration between epidemiologists, clinicians, experimental biologists, bioinformaticians and epigeneticists |
| Start Year | 2014 |
| Description | GW4 |
| Organisation | University of Bath |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The GW4 strategic alliance has established the GW4 Epigenetics Consortium which I instigated and brings complementary expertise from the 4 contributing Universitites together.We hosted a 2 day symposium and workshops and have subsequently secured and undertaken research activities around the use of CRISPR/Cas9 in epigenetics studies |
| Collaborator Contribution | 2 day symposium and workshops. Epidemiology expertise. |
| Impact | 2 day symposium and workshops. Further grant application to GW4 for research activities. This is a multi-disciplinary collaboration between epidemiologists, clinicians, experimental biologists, bioinformaticians and epigeneticists |
| Start Year | 2014 |
| Description | GW4 |
| Organisation | University of Exeter |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The GW4 strategic alliance has established the GW4 Epigenetics Consortium which I instigated and brings complementary expertise from the 4 contributing Universitites together.We hosted a 2 day symposium and workshops and have subsequently secured and undertaken research activities around the use of CRISPR/Cas9 in epigenetics studies |
| Collaborator Contribution | 2 day symposium and workshops. Epidemiology expertise. |
| Impact | 2 day symposium and workshops. Further grant application to GW4 for research activities. This is a multi-disciplinary collaboration between epidemiologists, clinicians, experimental biologists, bioinformaticians and epigeneticists |
| Start Year | 2014 |
| Description | GenR-ADHD |
| Organisation | Erasmus MC |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Joint analysis of ALSPAC and GenR epigenetic data |
| Collaborator Contribution | Joint analysis of ALSPAC and GenR epigenetic data |
| Impact | Association between DNA methylation and ADHD symptoms from birth to school age: A prospective meta-analysis Alexander Neumann, Esther Walton, Silvia Alemany, Charlotte Cecil, Juan Ramon González, Dereje Demissie Jima, Jari Lahti, Samuli T. Tuominen, Edward D. Barker, Elisabeth Binder, Doretta Caramaschi, Ángel Carracedo, Darina Czamara, Jorunn Evandt, Janine F. Felix, Bernard F. Fuemmeler, Kristine B. Gutzkow, Cathrine Hoyo, Jordi Julvez, Eero Kajantie, Hannele Laivuori, Rachel Maguire, Léa Maitre, Susan K. Murphy, Mario Murcia, Pia M. Villa, Gemma Sharp, Jordi Sunyer, Katri Raikkönen, Marian Bakermans-Kranenburg, Marinus van IJzendoorn, Mònica Guxens, Caroline L Relton, Henning Tiemeier doi: https://doi.org/10.1101/806844 Under review at Molecular Psychiatry |
| Start Year | 2016 |
| Description | GoDMC: Genetics of DNA Methylation Consortium |
| Organisation | Austrian Academy of Sciences |
| Department | Research Centre for Molecular Medicine |
| Country | Austria |
| Sector | Academic/University |
| PI Contribution | We are currently leading the GoDMC consortium. The GoDMC consortium consists of five core groups (IEU, Kings College London, University of Exeter, Leiden University Medical Centre and Austrian Academy of Sciences) and we recruited 30+ cohorts to contribute to the GoDMC consortium. Matt Suderman and Josine Min have developed an R package "Efficient algorithms for analyzing DNA methylation data" (meffil) (https://github.com/perishky/meffil) which is designed to conduct quality control and normalization of large-scale methylation datasets. Meffil also conducts epigenome wide association studies (EWAS) using four different methods. In addition, Josine Min and Gibran Hemani have written a pipeline on github, which automates all analyses. Participating cohorts will download the pipeline and will follow instructions to run the pipeline. |
| Collaborator Contribution | We have monthly calls with the core team to discuss analyses and there are weekly calls between analysts for technical issues. The core analysts are testing the pipeline on their cohorts externally. |
| Impact | Software development: R package meffil and github pipeline for GoDMC analyses Disciplines: Genetic epidemiology, epigenetic epidemiology |
| Start Year | 2013 |
| Description | GoDMC: Genetics of DNA Methylation Consortium |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We are currently leading the GoDMC consortium. The GoDMC consortium consists of five core groups (IEU, Kings College London, University of Exeter, Leiden University Medical Centre and Austrian Academy of Sciences) and we recruited 30+ cohorts to contribute to the GoDMC consortium. Matt Suderman and Josine Min have developed an R package "Efficient algorithms for analyzing DNA methylation data" (meffil) (https://github.com/perishky/meffil) which is designed to conduct quality control and normalization of large-scale methylation datasets. Meffil also conducts epigenome wide association studies (EWAS) using four different methods. In addition, Josine Min and Gibran Hemani have written a pipeline on github, which automates all analyses. Participating cohorts will download the pipeline and will follow instructions to run the pipeline. |
| Collaborator Contribution | We have monthly calls with the core team to discuss analyses and there are weekly calls between analysts for technical issues. The core analysts are testing the pipeline on their cohorts externally. |
| Impact | Software development: R package meffil and github pipeline for GoDMC analyses Disciplines: Genetic epidemiology, epigenetic epidemiology |
| Start Year | 2013 |
| Description | GoDMC: Genetics of DNA Methylation Consortium |
| Organisation | Leiden University Medical Center |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We are currently leading the GoDMC consortium. The GoDMC consortium consists of five core groups (IEU, Kings College London, University of Exeter, Leiden University Medical Centre and Austrian Academy of Sciences) and we recruited 30+ cohorts to contribute to the GoDMC consortium. Matt Suderman and Josine Min have developed an R package "Efficient algorithms for analyzing DNA methylation data" (meffil) (https://github.com/perishky/meffil) which is designed to conduct quality control and normalization of large-scale methylation datasets. Meffil also conducts epigenome wide association studies (EWAS) using four different methods. In addition, Josine Min and Gibran Hemani have written a pipeline on github, which automates all analyses. Participating cohorts will download the pipeline and will follow instructions to run the pipeline. |
| Collaborator Contribution | We have monthly calls with the core team to discuss analyses and there are weekly calls between analysts for technical issues. The core analysts are testing the pipeline on their cohorts externally. |
| Impact | Software development: R package meffil and github pipeline for GoDMC analyses Disciplines: Genetic epidemiology, epigenetic epidemiology |
| Start Year | 2013 |
| Description | GoDMC: Genetics of DNA Methylation Consortium |
| Organisation | University of Exeter |
| Department | Medical School |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We are currently leading the GoDMC consortium. The GoDMC consortium consists of five core groups (IEU, Kings College London, University of Exeter, Leiden University Medical Centre and Austrian Academy of Sciences) and we recruited 30+ cohorts to contribute to the GoDMC consortium. Matt Suderman and Josine Min have developed an R package "Efficient algorithms for analyzing DNA methylation data" (meffil) (https://github.com/perishky/meffil) which is designed to conduct quality control and normalization of large-scale methylation datasets. Meffil also conducts epigenome wide association studies (EWAS) using four different methods. In addition, Josine Min and Gibran Hemani have written a pipeline on github, which automates all analyses. Participating cohorts will download the pipeline and will follow instructions to run the pipeline. |
| Collaborator Contribution | We have monthly calls with the core team to discuss analyses and there are weekly calls between analysts for technical issues. The core analysts are testing the pipeline on their cohorts externally. |
| Impact | Software development: R package meffil and github pipeline for GoDMC analyses Disciplines: Genetic epidemiology, epigenetic epidemiology |
| Start Year | 2013 |
| Description | Harvard School of Public Health |
| Organisation | Harvard University |
| Department | Harvard T.H. Chan School of Public Health |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Epigenetic epidemiology expertise |
| Collaborator Contribution | Social epidemiology and social determinants of health. This collaboration, primarily with Prof Nancy Krieger, involves collaboration on biosocial epigenetics research. Prof Krieger leads a unique study on racial and economic discrimination on which we are planning epigenetic studies. NIH R01 funded in 2020 to run for 3 years 7 months. Relton & Krieger MPIs. |
| Impact | Collaborators are involved in Relton CL (PI), Davey Smith G, Power C, Deary I, Davies N, Tilling K, Gaunt T, Munafo M, Windmeijer F, Visscher P, Marioni R, Ingram N, van den Berg G, Murtagh M. Epigenetics: Environment, Embodiment and Equality (E4). ESRC. £667,460. Preparations are in progress for an NIH grant submission. |
| Start Year | 2014 |
| Description | IARC |
| Organisation | International Agency for Research on Cancer (IARC) |
| Country | France |
| Sector | Academic/University |
| PI Contribution | This long-standing collaboration (consolidated by a short sabbatical in 2008) led to a large scale NIH funded biomarker study which is ongoing. More recently, a CRUK programme in integrative cancer epidemiology has been awarded on which I am Co-PI. I bring programme leadership and epigenetic epidemiology and causal analysis expertise. |
| Collaborator Contribution | Genetic epidemiology and access to large multi-national consortia. |
| Impact | P Brennan, M Johansson, CL Relton, PM Ueland, P Vineis et al. One carbon metabolism biomarkers and lung cancer risk. Sep 2011-Aug 2016 NIH/NCI R01 [$5,060,000] Co-I Martin RM (Co-PI), Relton CL (Co-PI) et al. Reducing the burden of cancer: Causal risk factors, mechanistic targets and predictive biomarkers. £4.15M. CRUK Programme. Jun 2015 - May 2020. Johansson M, Fanidi A, Muller D, Bassett J, Midttun Ø, Vollset SE, Travis R, Palli D, Mattiello A, Sieri S, Trichopoulou A, Lagiou P, Trichopoulos D, Ljungberg B, Hallmans G, Weiderpass E, Skeie G, González C, Dorronsoro M, Peeters P, Bueno-de-Mesquita HB, Ros M, Boutron-Ruault MC, Fagherazzi G, Clavel-Chapelon F, Sánchez MJ, Barricarte Gurea A, Navarro C, Quirós JR, Overvad K, Tjønneland A, Aleksandrova K, Vineis P, Gunter M, Giles G, Relton C, Riboli E, Boeing H, Ueland PM, Severi G, Brennan P. Circulating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survival. J Natl Cancer Inst 2014;106(12):pii. PMID: 25376861 Fanidi A, Relton CL, Ueland PM, Midtun Ø, Vollset SE, Travis RC, Trichopoulou A, Lagiou P, Trichopoulos D, Bueno-de-Mesquita HB, Ros M, Boeing H, Tumino R, Panico S, Palli D, Sieri S, Vineis P, Sánchez MJ, Huerta JM, Barricarte Gurrea A, Luján-Barroso L, Quirós JR, Tjønneland A, Halkjær J, Boutron-Ruault MC, Clavel-Chapelon F, Cadeau C, Weiderpass E, Johansson M, Riboli E, Brennan P, Johansson M. A prospective study of one-carbon metabolism biomarkers and cancer of the head, neck and oesophagus. Int J Cancer 2014;136(4):915-27. PMID: 24975698 Fasanelli F, Baglietto L, Ponzi E, Guida F, Campanella G, Johansson M, Grankvist K, Johansson M, Assumma MB, Naccarati A, Chadeau-Hyam M, Ala U, Faltus C, Kaaks R, Risch A, De Stavola B, Hodge A, Giles GG, Southey MC, Relton CL, Haycock PC, Lund E, Polidoro S, Sandanger TM, Severi G, Vineis P. Hypomethylation of smoking-related gene is associated with future lung cancer in four prospective cohorts. Nat Commun 2015 Dec 15;6:10192. doi: 10.1038/ncomms10192. PMID: 26667048 Multiple additional manuscripts. Renewal of CRUK-funded programme grant from 2020-2025, with a larger body of research planned. |
| Start Year | 2007 |
| Description | KCL - Epigenetics |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We bring epidemiological expertise and expertise in causal analysis methodology to a series of collaborations. We have collaborated on joint research proposals which have been successful. |
| Collaborator Contribution | Our collaborators bring the following expertise; Dr Helen Fisher: Social Science and Psychiatry Dr Ted Barker: Conduct problems Dr Jordana Bell; Twin studies |
| Impact | Dr Fisher was awarded a MQ Fellowship on which I act as a sponsor. We are Co-Investigators on a recently awarded ESRC grant; Howe L, Relton CL (Co-I), Davey Smith G, Gaunt T, Suderman M, Simpkin A, Davies N, Shihab H, Marioni R, Hardy R, Wong C, Fisher H, John R, Jerrim J, Deary I, Mill J. Interpreting epigenetic signatures in studies of early life adversity (InterSTELA) ESRC. £195,513. Drs Bell and Fisher is a collaborator on a further ESRC grant of which I am PI; Relton CL (PI), Davey Smith G, Power C, Deary I, Davies N, Tilling K, Gaunt T, Munafo M, Windmeijer F, Visscher P, Marioni R, Ingram N, van den Berg G, Murtagh M. Epigenetics: Environment, Embodiment and Equality (E4). ESRC. £667,460. We have collaborated with Dr Barker on a NIH-funded project; E Barker, J Mill, G Davey Smith, B Maughan, CL Relton. Epigenetic pathways to conduct problem trajectories: the role of prenatal and postnatal environmental risk exposures. Jan 2012-Dec 2016 NIH/NICHD [£1,100,000] Co-I. With the following outputs; Cecil CAM, Lysenko LJ, Jaffee SR, Pingault J-B, Smith RG, Relton CL, Woodward G, McArdle W, Mill J, Barker ED. Environmental risk, oxytocin receptor gene (OXTR) methylation and youth callous-unemotional traits: A 13-year longitudinal study. Mol Psychiatry 2014;19(10):1071-7. PMID: 25199917 Rijlaarsdam J, Pappa I, Walton E, Bakermans-Kranenburg MJ, Mileva-Seitz VR, Rippe RC, Roza SJ, Jaddoe VW, Verhulst FC, Felix JF, Cecil CA, Relton CL, Gaunt TR, McArdle W, Mill J, Barker ED, Tiemeier H, van Ijzendoom MH. An epigenome-wide association meta-analysis of prenatal maternal stress in neonates: A model approach for replication. Epigenetics 2016. In Press. Further papers are under review. Dr Bell is a co-PI of the Genetics of DNA Methylation Consortium (GoDMC). |
| Start Year | 2013 |
| Description | Leiden University Medical Centre |
| Organisation | Leiden University Medical Center |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We have collaborated on the ARIES study which included the profiling of DNA methylation in autopsy samples provided by Dr Bas Heijman's group at LUMC in our Bristol labs. We have cleaned and QC'd the data and contributed to data analysis. We also work closely with this group in leading the Genetics of DNA Methylation Consortium (GoDMC). |
| Collaborator Contribution | Our collaborators provided autopsy biological samples and associated data. They have led the data analysis and preparation of findings for publication. |
| Impact | A Data Resource Profile has been published; Relton CL, Gaunt T, McArdle W, Ho K, Duggirala A, Shihab H, Woodward G, Lyttleton O, Evans DM, Reik W, Paul YL, Ficz G, Ozanne SE, Wipat A, Flanagan K, Lister A, Heijmans BT, Ring SM, Davey Smith G. Data Resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES). Int J Epidemiol 2015;44(4):1181-90. PMID: 25991711 A further publication describing methylation profiles in different tissues is in preparation. |
| Start Year | 2013 |
| Description | Longitudinal_epi_GenR - E Walton |
| Organisation | Erasmus MC |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | joint analysis of ALSPAC and GenR epigenetic data |
| Collaborator Contribution | joint analysis of ALSPAC and GenR epigenetic data |
| Impact | 188. Walton E, Relton CL, Caramaschi D. Using openly accessible resources to strengthen causal inference in epigenetic epidemiology of neurodevelopment and mental health. Genes 2019 Mar 1;10(3). pii: E193. doi: 10.3390/genes10030193. PMID:308903164. Additional publications in preparation |
| Start Year | 2016 |
| Description | MRC Lifecourse Epidemiology Unit - Southampton |
| Organisation | University of Southampton |
| Department | MRC Lifecourse Epidemiology Unit |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I chaired the Steering Group of a MRC-Newton Fund UK-India & Africa Project; Epigenetic mechanisms linking maternal pre-conceptional micronutrient supplementation with offspring health in India and The Gambia (2016-2018). I also continue to collaborate with epigenetics researchers at the University of Southampton, mainly in the context of meta-analytical studie4s or replication of discovery findings. |
| Collaborator Contribution | Opportunity to contribute to a multi-national epigenetics project and share our knowledge and expertise in epigenetic epidemiology and causal analysis methods |
| Impact | First Steering Group meeting, held in Hyderabad Feb 2016. 2nd Steering Group, held in The Gambia 2017. Various co-authored publications (middle author). |
| Start Year | 2013 |
| Description | MRC The Gambia |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Unit, The Gambia |
| Country | Gambia |
| Sector | Public |
| PI Contribution | Collaboration in epigenetics research. Co-investigator on recently funded award to establish a W African Bioresource in nutritional genetics and epigenetics. |
| Collaborator Contribution | Myself and members of my team have committed to helping our colleagues at the MRC Gambia Unit establish a bioresource to support molecular epidemiology research in the future. This will involve researcher exchanges,workshops and training in Bristol and the provision of ongoing support and capacity building in The Gambia. |
| Impact | Capacity building achieved through sharing of good practice. |
| Start Year | 2018 |
| Description | MRC Unit for LIfelong Health and Ageing |
| Organisation | University College London |
| Department | MRC Unit for Lifelong Health and Ageing |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We bring epigenetics expertise to this collaboration. The NSHD (MRC 1946 Study) complements the Bristol-based ALSPAC study. I am a member of the NSHD Biosample Access Committee |
| Collaborator Contribution | We collaborate on a variety of studies including epigenetics of the menopausal transition and the role of biosocial factors in epigenetic variation. The NSHD is a collaborating cohort on a recently awarded ESRC project grant. |
| Impact | Relton CL (PI), Davey Smith G, Power C, Deary I, Davies N, Tilling K, Gaunt T, Munafo M, Windmeijer F, Visscher P, Marioni R, Ingram N, van den Berg G, Murtagh M. Epigenetics: Environment, Embodiment and Equality (E4). ESRC. £667,460. Howe L, Relton CL (Co-I), Davey Smith G, Gaunt T, Suderman M, Simpkin A, Davies N, Shihab H, Marioni R, Hardy R, Wong C, Fisher H, John R, Jerrim J, Deary I, Mill J. Interpreting epigenetic signatures in studies of early life adversity (InterSTELA) ESRC. £195,513. |
| Start Year | 2013 |
| Description | Norwegian Institute of Public Health |
| Organisation | Norwegian Institute of Public Health |
| Country | Norway |
| Sector | Public |
| PI Contribution | We bring epigenetic epidemiology expertise to this collaboration. |
| Collaborator Contribution | Access to a very large birth cohort as well as epidemiological and clincial expertise. |
| Impact | Inclusion in the PACE consortium. Training and exchange visits. Preparation of joint grant applications. Joint research publications e.g. "25-hydroxyvitamin D in pregnancy and genome wide cord blood DNA methylation in two pregnancy cohorts (MoBa and ALSPAC) The Journal of Steroid Biochemistry and Molecular Biology Suderman M, Stene LC, Bohlin J, Page CM, Holvik K, Parr CL, Magnus MC, Håberg Siri E, Joubert BR, Wu MC, London SJ, Relton C, Nystad W |
| Start Year | 2013 |
| Description | NutriPROGRAM consortium collaboration |
| Organisation | Barcelona Institute for Global Health |
| Country | Spain |
| Sector | Multiple |
| PI Contribution | We co-designed and lead work package 4 in the Nutriprogram consortium project. We also lead or contribute to several other activities in other work packages. |
| Collaborator Contribution | Other partners lead other work packages and contribute data and results to the work package we lead (WP4). |
| Impact | A collaboration agreement (including DTA) has been signed by all contributing members. The collaboration is multi-disciplinary, involving epidemiologists, geneticists, nutritionists, biologists and clinicians. |
| Start Year | 2019 |
| Description | NutriPROGRAM consortium collaboration |
| Organisation | Erasmus MC |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We co-designed and lead work package 4 in the Nutriprogram consortium project. We also lead or contribute to several other activities in other work packages. |
| Collaborator Contribution | Other partners lead other work packages and contribute data and results to the work package we lead (WP4). |
| Impact | A collaboration agreement (including DTA) has been signed by all contributing members. The collaboration is multi-disciplinary, involving epidemiologists, geneticists, nutritionists, biologists and clinicians. |
| Start Year | 2019 |
| Description | NutriPROGRAM consortium collaboration |
| Organisation | Ludwig Maximilian University of Munich (LMU Munich) |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | We co-designed and lead work package 4 in the Nutriprogram consortium project. We also lead or contribute to several other activities in other work packages. |
| Collaborator Contribution | Other partners lead other work packages and contribute data and results to the work package we lead (WP4). |
| Impact | A collaboration agreement (including DTA) has been signed by all contributing members. The collaboration is multi-disciplinary, involving epidemiologists, geneticists, nutritionists, biologists and clinicians. |
| Start Year | 2019 |
| Description | NutriPROGRAM consortium collaboration |
| Organisation | University of British Columbia |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | We co-designed and lead work package 4 in the Nutriprogram consortium project. We also lead or contribute to several other activities in other work packages. |
| Collaborator Contribution | Other partners lead other work packages and contribute data and results to the work package we lead (WP4). |
| Impact | A collaboration agreement (including DTA) has been signed by all contributing members. The collaboration is multi-disciplinary, involving epidemiologists, geneticists, nutritionists, biologists and clinicians. |
| Start Year | 2019 |
| Description | NutriPROGRAM consortium collaboration |
| Organisation | Wageningen University & Research |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We co-designed and lead work package 4 in the Nutriprogram consortium project. We also lead or contribute to several other activities in other work packages. |
| Collaborator Contribution | Other partners lead other work packages and contribute data and results to the work package we lead (WP4). |
| Impact | A collaboration agreement (including DTA) has been signed by all contributing members. The collaboration is multi-disciplinary, involving epidemiologists, geneticists, nutritionists, biologists and clinicians. |
| Start Year | 2019 |
| Description | PURE-South Africa - H Elliott |
| Organisation | North-West University |
| Country | South Africa |
| Sector | Academic/University |
| PI Contribution | This collaboration is concerned with capacity building in epigenetic epidemiology in S Africa. Focused on a joint project comparing epigenetic signatures in rural and urban dwelling individuals. My research team had contributed through the provision of advice on study design, samples processing and data generation at the University of Bristol, training in data analysis, support in drafting outputs. |
| Collaborator Contribution | Intellectual contributions, sample provision, some funding for sample analysis. |
| Impact | None yet |
| Start Year | 2018 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | Center for Environmental Research and Children's Health |
| Department | The CHAMACOS Study |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | Columbia Center for Children's Environmental Health |
| Country | United States |
| Sector | Private |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | European Association for Research on Learning and Instruction (EARLI) |
| Country | Belgium |
| Sector | Public |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | European Huntington's Disease Network (Euro-HD) |
| Country | Germany |
| Sector | Charity/Non Profit |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | Federal Ministry for the Environment, Nature Conservation and Nuclear Safety (BMU) |
| Department | International Climate Initiative (ICI) |
| Country | Germany |
| Sector | Public |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | Finnish Birth Cohort |
| Country | Finland |
| Sector | Academic/University |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | GECKO Drenthe Birth Cohort |
| Country | Netherlands |
| Sector | Hospitals |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | GenExp |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | GenR |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | Glyndwr University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | Government of Canada |
| Department | Aboriginal Affairs and Northern Development |
| Country | Canada |
| Sector | Public |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | ITS United Kingdom |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | Inmarsat |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | MTT Ltd Machine Tools Technologies |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | National Heart, Lung, and Blood Institute (NHLBI) |
| Country | United States |
| Sector | Public |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | National Institute of Environmental Health Sciences |
| Department | Norway Facial Clefts Study (NCL) |
| Country | United States |
| Sector | Public |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | National Institute of Standards & Technology (NIST) |
| Country | United States |
| Sector | Public |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | New Hampshire Birth Cohort Study |
| Country | United States |
| Sector | Private |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | PRISMA ONG |
| Country | Peru |
| Sector | Private |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | Progressive Energy Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | Project Viva |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | Rhode Island Child Health Study |
| Sector | Charity/Non Profit |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | Rutherford Appleton Laboratory |
| Department | Space Science and Technology Department |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | University of Bristol |
| Department | Avon Longitudinal Study of Parents and Children (ALSPAC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | University of Cambridge |
| Department | PomBase |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | University of Western Australia |
| Department | Raine Medical Research Foundation |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | VCE Mobile & Personal Comm Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Public Health Foundation India |
| Organisation | Public Health Foundation of India |
| Country | India |
| Sector | Public |
| PI Contribution | I supervise a PHFI Postdoctoral Fellow, Dr Gagandeep Kaur Walia. I regularly host this fellow in my research group and provide ad hoc research support and advice to her. |
| Collaborator Contribution | Cultural diversity and the opportunity to collaborate with Indian cohort studies. |
| Impact | Kaur Walia G. Public Health Foundation of India-UK Joint Fellowship. Jul 2015-Jun2017. Supervisor. Gupta V, Saxena R, Walia GK, Aggarawal T, Dunn WB, Relton CL, Sovio U, Papegeorghiou A, Davey Smith G, Khadgawal R, Sachdeva MP. Gestational route to healthy birth (GaRBH): protocol for an Indian prospective cohort study. BMJ Open. 2019 May 1;9(4):e025395. doi: 10.1136/bmjopen-2018-025395. PMID:31048433. Agarwal T, Lyngdoh T, Dudbridge F, Chandak GR, Sinra S, Prabhakaran D, Reddy KS, Relton CL, Davey Smith G, Ebrahim S, Gupta V, Walia GK. Causal relationships between lipid and glycaemic traits in an Indian population: A bidirectional Mendelian randomization approach. PLoS One. 2020 Jan 29;15(1):e0228269. Doi: 10.1371/journal.pone.0228269. eCollection 2020. PMID:31995593. |
| Start Year | 2013 |
| Description | Sanofi Aventis |
| Organisation | Sanofi |
| Department | Aventis |
| Country | France |
| Sector | Private |
| PI Contribution | Epigenetics expertise and functional annotation of target loci identified by the collaborators |
| Collaborator Contribution | Direction in terms of target prioritization as well as financial support for a postdoctoral assistant. |
| Impact | An Annotation pipeline has been developed to provide information on potential targets. Richardson TG, Haycock PC, Zheng J, Timpson NJ, Gaunt TR, Davey Smith G, Relton CL, Hemani G. Systematic Mendelian randomization framework elucidates hundreds of CpG sites which may mediate the influence of genetic variants on disease. Hum Mol Genet. 2018 Sep 15;27(18):3293-3304. doi: 10.1093/hmg/ddy210. PMID:29893838. |
| Start Year | 2015 |
| Description | UFPel |
| Organisation | Federal University of Pelotas (UFPel) |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | Epigenetic epidemiology expertise. Training provision (hosting of visiting researchers and delivery of training in Brazil) Contribution to co-supervision of a PhD student |
| Collaborator Contribution | Access to unique Brazilian birth cohorts. Maternal and perinatal epidemiology |
| Impact | Relton CL, Hartwig FP Davey Smith G. From stem cells to the law courts: DNA methylation, the forensic epigenome and the possibility of a biosocial archive. Int J Epidemiol 2015 44 (4): 1083-1093. doi: 10.1093/ije/dyv198 Genomics, Epigenomics and Causal Inference in Population Health, Federal University of Pelotas, Brazil, March 2015 |
| Start Year | 2013 |
| Description | University of Exeter Medical School |
| Organisation | University of Exeter |
| Department | Medical School |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | My team collaborates with genetic epidemiologists and epigeneticists at this institution. I am a collaborator on the Wellcome Trust Sir Henry Dale Felowship of Dr Rachel Freathy. I also bring epidemiological expertise to our collaboration with Prof Jonathan Mill, with whom we have obtained joint funding. |
| Collaborator Contribution | Dr Freathy undertakes large scale genetic epidemiology and utilises samples from our studies. Prof Mill brings epigenetic expertise as well as tissue specific epigenetic studies. We collaborate with Prof Mills in the leadership of the genetics of DNA methylation Consortium (GoDMC). |
| Impact | GW4 Initiator grant to establish a GW Epigenetics Consortium GW4 Accelerator grant (CRISPR/Cas) to pilot gene editing on epigenetic loci. Prof Mill is a co-PI on the Genetics of DNA Methylation Consortium |
| Start Year | 2013 |
| Description | University of Memphis |
| Organisation | University of Memphis |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Collaborations with two groups concerned with molecular changes during puberty and their relation to asthma risk. My team has contributed to study design, data provision, data analysis and drafting of manuscripts. |
| Collaborator Contribution | Study design, data generation, writing of manuscripts, provision of funding. |
| Impact | Publications jointly co-authored by multi-disciplinary team including clinicians, statisticians and epigeneticists. |
| Start Year | 2015 |
| Description | University of Queensland |
| Organisation | University of Queensland |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Epigenetic epidemiology and causal analysis expertise |
| Collaborator Contribution | Quantitative genetics expertise |
| Impact | Evans D (PI), Relton C, Davey Smith G Powell J. Novel ways of utilizing genome-wide DNA methylation data from peripheral blood samples in genetic epidemiology. ~£400k. NHMRC. Jan 2015 - Dec 2017. Involvement in recently awarded project: Relton CL (PI), Davey Smith G, Power C, Deary I, Davies N, Tilling K, Gaunt T, Munafo M, Windmeijer F, Visscher P, Marioni R, Ingram N, van den Berg G, Murtagh M. Epigenetics: Environment, Embodiment and Equality (E4). ESRC. £667,460. |
| Start Year | 2013 |
| Title | EWAS Catalog |
| Description | This webtool/application has curated all published epigenome-wide association studies (EWAS) (using the Illumina BeadChip platform) and incorporated them in to a searchable data base. This allows the user to locate any variable methylation probes they may be interested in in a similar way to the GWAS catalog for genetic variants. It provides a centralised repository and search tool for any investigator interested in EWAS. |
| Type Of Technology | Webtool/Application |
| Year Produced | 2018 |
| Open Source License? | Yes |
| Impact | The web application has just been released. It should have considerable impact across the research community as a browsing facility for all documented EWAS that appear in the published literature. |
| URL | http://www.ewascatalog.org |
| Description | Co-coordinator and lecturer on Swiss Epidemiology Winter School in 2019 - R.Richmond |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Rebecca Richmond presented a lecture to 20 Epidemiology students and researchers at the Swiss Epidemiology Winter School in 2019, this sparked discussions for future collaborations. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Citizen Science Project - R.Richmond |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Rebecca Richmond has been involved in a Citizen Science project taking place as part of the SPHERE initiative which has involved engaging and working with members of the project as part of a participant-led research project around sleep. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Creative Reactions 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | I took part in Creative Reactions, an initiative that pairs scientists with artists to create artwork based on their academic research. I was paired with Olga Trevisan, an artist based in Venice, Italy. Based on some of my research around the Developmental Origins of Health and Disease, Olga created a piece called Beyond Question, which comments on the complexities of scientific data collection, bias and interpretation. Interesting conversations with people viewing the artwork revealed that some people's opinions (about the importance of the maternal contribution to offspring health, relative to paternal and wider societal influences) were challenged and changed. The artwork was displayed at two exhibitions at different sites in Bristol, with two separate launch events attended by the local media. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://epoch.blogs.bristol.ac.uk/2019/12/21/beyond-question-a-collaboration-between-epoch-and-artis... |
| Description | Education in our genes |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | This one day workshop was aimed at both social and biomedical scientists to present current developments around the application of genetic and epigenetic data in relation the educational attainment and related characteristics |
| Year(s) Of Engagement Activity | 2017 |
| Description | Epigenetic Clock Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | A one day workshop was held to present and discuss approaches to research using the epigenetic clock as a biomarker of biological age. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Fun Palaces event planning - Rebecca Richmond |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Rebecca Richmond (ICEP Researcher) helped to organise a public engagement event relating to her e-cigarette study which was at Fun Palaces in Bristol in October 2017. Fun Palaces initiative is where community organisations lead events to connect public members with scientific research through creative interests or hobbies and expertise that may sit within those communities. The event allowed knowledge exchange between researchers and the public, informing about the demographic of e-cigarette use. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Greenman - R.Richmond |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Rebecca Richmond helped to organize and implement several public engagement activities in the "Einstein's Garden" of the Green Man Festival in 2018. More than 500 people attended. |
| Year(s) Of Engagement Activity | 2018 |
| Description | IGES conference - J.Staley |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | James Staley presented a conference poster to 250 people at the IGES Conference in San Diego, on the 18th October 2018. The poster/presentation is entitled: Longitudinal strategies for identifying genetic associations with epigenetic changes over time |
| Year(s) Of Engagement Activity | 2018 |
| Description | Inaugural Researchers' Summit for the new India-UK Cancer Research Initiative - C Relton |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof Caroline Relton (ICEP PI) was invited to attend the Inaugural Researchers' Summit for the new India-UK Cancer Research Initiative, a joint venture between Cancer Research UK and the Indian Government's Department of Biotechnology (DBT). This initiative seeks to establish new bilateral research alliances to undertake impactful research and develop innovative approaches to improving cancer outcomes. The Summit took place in New Delhi, India in November 2018 and brought together leading researchers, clinicians and technologists to identify the core research challenges under the broad theme of affordable approaches to cancer. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Molecular Epidemiology Group Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Annual scientific meeting of a multi-disciplinary academic group of international researchers |
| Year(s) Of Engagement Activity | 2019 |
| Description | NutriPROGRAM Twitter |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | We have a NutriPROGRAM Twitter account with nearly 50 followers. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://twitter.com/nutriprogram |
| Description | Presentation at Nutrition Symposium, Erasmus - C Relton |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof Caroline Relton was invited to present at Nutrition Symposium, Erasmus Medical Center in June 2018. Prof Relton presented: Causal analysis in epigenetic epidemiology. The talk prompted the following exchange of letters: http://advances.sciencemag.org/content/4/1/eaao4364/tab-e-letters. The talk also raised the profile of Prof Relton and her research. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://advances.sciencemag.org/content/4/1/eaao4364/tab-e-letters |
| Description | Statistics in Epigenetics Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | A one day workshop was held to describe and discuss recent key statistical advances for analysing DNA methylation data funded by an MRC grant. A keynote lecture was also given on the 'Estimation of a significance threshold for epigenome-wide association studies'. Over 60 post-grad students, fellow researchers, and health professionals attended this free workshop. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.eventbrite.co.uk/e/epigenetics-statistics-workshop-tickets-49889050493 |
| Description | Visit to Barshi, India - C Relton |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Professors Caroline Relton and George Davey Smith went to Barshi, India in May 2018. They visited the India Study for Health of Adults (Barshi Cohort Study) in action and the TATA Memorial Centre. Their trip included presenting to villages who were cohort participants and visiting the field site of the Barshi cohort. Future collaborations between Bristol and the TATA team were discussed. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Wellcome Training Workshop at OUCRU - C Relton |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Prof Caroline Relton (ICEP PI) visited OUCRU (Oxford University Clinical Research Unit) in Ho Chi Minh City and Hanoi, Vietnam for a week in April 2018. The workshops were set up by the Wellcome Trust, where Prof Relton delivered training in group leadership, the process of peer review, grant writing and career development to Wellcome-funded researchers of all stages based there. |
| Year(s) Of Engagement Activity | 2018 |