Mendelian randomization to hypothesis-free causal inference
Lead Research Organisation:
University of Bristol
Department Name: UNLISTED
Abstract
Obtaining reliable evidence on causes of disease and influences on disease progression is problematic, since many other factors than the ones under study may influence the outcomes. Using genetic variants that mimic potentially modifiable factors that may cause disease or influence its course has become a widely-used approach to improving such understanding. Known as “Mendelian randomization” the methodology is still under development. This programme of work will contribute to strengthening the reliability of the approach, and, in particular, investigate the application to identifying treatments for existing disease.
Technical Summary
Background: The MRC Integrative Epidemiology Unit (MRC-IEU) has pioneered the Mendelian randomization (MR) approach, which is now showing exponential growth in terms of breadth of application and number of publications. This has been fuelled by the coalescence of four trends (1) the rapid increase in the number of identified genetic variants related to exposures of interest to clinical investigators; (2) the maturation of UK Biobank and other large-scale population studies with accessible data, including from genome wide association study (GWAS) analysis; (3) the expansion in available data from GWAS consortia; and (4) the popularization of 2-sample MR analyses (2SMR), which allow causal estimates to be made from summary level data. We have developed a range of new methods that allow stronger inference to be drawn from MR studies and released a platform (MR-Base) for high-throughput 2SMR analysis. Both have been rapidly taken up by the scientific community. Our aims will considerably expand the range of questions that MR can address, include:
Aim 1: To increase the clinical utility of MR by conducting studies of disease progression, which will provide MR evidence that speaks directly to disease treatment
Aim 2: To develop approaches that subject the MR assumptions to further scrutiny through negative controls and the assessment of pleiotropy, together with developing structural equation modelling as a flexible strategy for analysis of MR studies
Aim 3: To conduct MR studies in family based data, which provides additional robustness checks, and allows estimation of maternal and paternal influences on offspring outcomes
Methods: The three aims will be advanced in parallel, within a programme that will utilise simulation, substantive analysis, replication and triangulation of evidence.
Translation will be facilitated by the new NIHR Bristol Biomedical Research Centre (Davey Smith Scientific Director) and through expanding our collaborations with industry.
Aim 1: To increase the clinical utility of MR by conducting studies of disease progression, which will provide MR evidence that speaks directly to disease treatment
Aim 2: To develop approaches that subject the MR assumptions to further scrutiny through negative controls and the assessment of pleiotropy, together with developing structural equation modelling as a flexible strategy for analysis of MR studies
Aim 3: To conduct MR studies in family based data, which provides additional robustness checks, and allows estimation of maternal and paternal influences on offspring outcomes
Methods: The three aims will be advanced in parallel, within a programme that will utilise simulation, substantive analysis, replication and triangulation of evidence.
Translation will be facilitated by the new NIHR Bristol Biomedical Research Centre (Davey Smith Scientific Director) and through expanding our collaborations with industry.
People |
ORCID iD |
Publications
Wade KH
(2022)
Applying Mendelian randomization to appraise causality in relationships between nutrition and cancer.
in Cancer causes & control : CCC
Battram T
(2019)
Appraising the causal relevance of DNA methylation for risk of lung cancer
in International Journal of Epidemiology
Yarmolinsky J
(2019)
Appraising the role of previously reported risk factors in epithelial ovarian cancer risk: A Mendelian randomization analysis.
in PLoS medicine
Liu CY
(2021)
Are there causal relationships between attention-deficit/hyperactivity disorder and body mass index? Evidence from multiple genetically informed designs.
in International journal of epidemiology
Morales Berstein F
(2022)
Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study.
in eLife
Liu J
(2022)
Assessing the Causal Role of Sleep Traits on Glycated Hemoglobin: A Mendelian Randomization Study.
in Diabetes care
Ambatipudi S
(2018)
Assessing the Role of DNA Methylation-Derived Neutrophil-to-Lymphocyte Ratio in Rheumatoid Arthritis.
in Journal of immunology research
Budu-Aggrey A
(2021)
Assessment of a causal relationship between body mass index and atopic dermatitis
in Journal of Allergy and Clinical Immunology
Riglin L
(2021)
Assessment of age-at-onset criterion for adult attention-deficit hyperactivity disorder.
in The British journal of psychiatry : the journal of mental science
Related Projects
| Project Reference | Relationship | Related To | Start | End | Award Value |
|---|---|---|---|---|---|
| MC_UU_00011/1 | 01/04/2018 | 31/03/2023 | £2,864,000 | ||
| MC_UU_00011/2 | Transfer | MC_UU_00011/1 | 01/04/2018 | 31/03/2023 | £965,000 |
| MC_UU_00011/3 | Transfer | MC_UU_00011/2 | 01/04/2018 | 31/03/2023 | £1,011,000 |
| MC_UU_00011/4 | Transfer | MC_UU_00011/3 | 01/04/2018 | 31/03/2023 | £1,329,000 |
| MC_UU_00011/5 | Transfer | MC_UU_00011/4 | 01/04/2018 | 31/03/2023 | £1,254,000 |
| MC_UU_00011/6 | Transfer | MC_UU_00011/5 | 01/04/2018 | 31/03/2023 | £1,640,000 |
| MC_UU_00011/7 | Transfer | MC_UU_00011/6 | 01/04/2018 | 31/03/2023 | £1,083,000 |
| Description | Response to consultation on 'Adding Folic Acid to Flour' by UK Government |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| Description | (BIOMAP) - Biomarkers in Atopic Dermatitis and Psoriasis |
| Amount | € 20,884,846 (EUR) |
| Funding ID | 821511 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 04/2019 |
| End | 03/2024 |
| Description | Assessing the INSIDE assumption in Mendelian randomization. Bristol 'Next Generation' Visiting Researcher Programme. |
| Amount | £24,370 (GBP) |
| Organisation | University of Bristol |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2020 |
| End | 09/2022 |
| Description | BHF 4-year PhD programme in Integrated Cardiovascular Science |
| Amount | £1,439,856 (GBP) |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2021 |
| End | 09/2028 |
| Description | CHARGE consortium: omics discovery for CVD and aging phenotypes. |
| Amount | $204,358,300 (USD) |
| Funding ID | R01 HL105756-11 |
| Organisation | National Institutes of Health (NIH) |
| Sector | Public |
| Country | United States |
| Start | 08/2022 |
| End | 06/2025 |
| Description | CRUK Integrative Cancer Epidemiology Programme |
| Amount | £7,715,113 (GBP) |
| Funding ID | C18281/A29019 |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2020 |
| End | 09/2025 |
| Description | Characterising the relationship between NAFLD and T2D using genetic insights. |
| Amount | 4,000,000 kr. (DKK) |
| Funding ID | NNF180C0031650 |
| Organisation | Novo Nordisk |
| Sector | Private |
| Country | Denmark |
| Start | 06/2018 |
| End | 05/2022 |
| Description | Confidence in Global Mental Health |
| Amount | £173,000 (GBP) |
| Funding ID | MR/R019622/1 |
| Organisation | University of Bristol |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 04/2019 |
| Description | Developing cross-population Mendelian randomization for generalizing evidence on drug targets: the MRC Cross-Population Mendelian Randomization Network. |
| Amount | £118,937 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2022 |
| End | 12/2023 |
| Description | From clustered behaviours to molecular mechanisms in cancer epidemiology |
| Amount | £260,000 (GBP) |
| Organisation | University of Bristol |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 09/2022 |
| Description | Identifying maternal and fetal genetic determinants of infant birthweight and their relationship to offspring cardiometabolic risk |
| Amount | $3,679,200 (USD) |
| Funding ID | APP1157714 |
| Organisation | National Health and Medical Research Council |
| Sector | Public |
| Country | Australia |
| Start | 01/2019 |
| End | 12/2021 |
| Description | Investigating the differential geographical, sociodemographic and genetic predictors of mental illness and wellbeing using longitudinal survey data |
| Amount | £99,888 (GBP) |
| Funding ID | ES/T009101/1 |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2020 |
| End | 12/2020 |
| Description | Is there a causal link between primary open angle glaucoma and dementia? |
| Amount | £14,852 (GBP) |
| Funding ID | SGA18_011 |
| Organisation | Fight for Sight |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2019 |
| End | 01/2020 |
| Description | MICA: NURTuRE - changing the landscape of renal medicine to foster a unified approach to stratified medicine |
| Amount | £2,561,603 (GBP) |
| Funding ID | MR/R013942/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2018 |
| End | 07/2022 |
| Description | Metabolomically healthy obesity" in the age of high-throughput metabolomics: Studying personalized medicine in 30,000 individuals. |
| Amount | 2,026,128 kr (SEK) |
| Organisation | Danish Council for Independent Research |
| Sector | Public |
| Country | Denmark |
| Start | 08/2019 |
| End | 07/2022 |
| Description | NIHR Bristol Biomedical Research Centre |
| Amount | £11,694,330 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2022 |
| End | 11/2027 |
| Description | The causal map of the human phenome. |
| Amount | £809,240 (GBP) |
| Funding ID | 208806 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 03/2023 |
| Description | The role of bone and joint size and shape in explaining common musculoskeletal diseases. |
| Amount | £1,565,599 (GBP) |
| Funding ID | 209233 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 08/2023 |
| Description | Use of Mendelian randomisation to examine the role of abnormal hip shape in the development of hip osteoarthritis |
| Amount | £243,926 (GBP) |
| Funding ID | MR/S021280/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 08/2022 |
| Title | Genetic instruments for Mendelian Randomization analyses of childhood and adult BMI |
| Description | This file lists variants used as instrumental variables for the manuscript "Separating the effects of childhood and adult body size on inflammatory arthritis: a Mendelian randomisation study". We selected independent (linkage disequilibrium threshold of r2<0.001 using PLINK and a reference panel of 10,000 randomly selected Europeans from UK Biobank) genome-wide significant (p<5x10-8) SNPs, resulting in 313 childhood and 580 adult body size instruments. For multivariable MR, we repeated LD clumping for the combined set of SNPs from both exposures. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Data set to accompany paper published. |
| URL | https://figshare.manchester.ac.uk/articles/dataset/Genetic_instruments_for_Mendelian_Randomization_a... |
| Description | BIOMAP Biomarkers in Atopic Dermatitis and Psoriasis |
| Organisation | University of Kiel |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Provision of several key datasets, Lead on two key tasks (covering GWAS, EWAS and TWAS of subtypes of eczema and psoriasis - including disease progression) |
| Collaborator Contribution | Provision of some datasets, profiling of samples, and conducting other aspects of the analysis |
| Impact | No outputs yet. Multidisciplinary: Clinical, Epidemiology, Molecular Biology, Mathematical modelling, Ethics, Industrial collaborators |
| Start Year | 2019 |
| Description | Pfizer - causal influences on smoking cessation |
| Organisation | Pfizer Inc |
| Country | United States |
| Sector | Private |
| PI Contribution | Advice on MR methodologies and causal analysis methods |
| Collaborator Contribution | Advice on accessing clinical trial data from Pharmaceutical companies. Provision of data set. |
| Impact | Dataset shared. No published outputs to date |
| Start Year | 2019 |
| Description | Takeda Causal Risk Factors for Cognitive Decline |
| Organisation | Takeda Pharmaceutical Company |
| Country | Japan |
| Sector | Private |
| PI Contribution | Advice on MR methodology and analysis approaches. |
| Collaborator Contribution | Discussion and advice on accessing clinical trial data from Pharmaceutical companies for disease progression studies. Provision of datasets. |
| Impact | The collaboration resulted in Takeda funding a 24 month research project. |
| Start Year | 2019 |
| Description | UPenn |
| Organisation | University of Pennsylvania |
| Department | Perelman School of Medicine |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Analyst and specialist knowledge of MR |
| Collaborator Contribution | Data provision (Penn Medicine Biobank [PMBB] and Million Veteran Program [MVP]) and specialist knowledge of cardiovascular phenotypes, particularly peripheral artery disease (PAD) |
| Impact | Manuscript drafted for analysis titled 'Separating the effects of cardiometabolic traits from type 2 diabetes on coronary and peripheral artery disease'. Analyses ongoing to explore how to best capture blood pressure over time as a phenotype using PMBB data. Analyses ongoing to explore risk factors for type 2 diabetes complications (including PAD) using MVP data. |
| Start Year | 2019 |
| Title | Software for adjusting outliers for horizontal pleiotropy ('Treasure your exceptions') |
| Description | This software uses the OpenGWAS database to estimate the relationships between an outlying variant in an MR analysis with a large range of other possible traits. It then constructs an estimate of the effect of the other associating traits on the outcome trait, to adjust the outlying effect for known pleiotropic pathways |
| Type Of Technology | Software |
| Year Produced | 2020 |
| Open Source License? | Yes |
| Impact | This software has been published in Nature Communications and is being used by external researchers in the field |
| URL | https://explodecomputer.github.io/tryx/ |
| Title | Software generating 'index of suspicion' in MR |
| Description | This software uses the OpenGWAS database to construct a pleiotropy score for a set of variables that are being used in a Mendelian randomisation analysis. This score, known as the index of suspicion, is then used to weight the contribution of the instruments to the overall estimate in the causal inference analysis. |
| Type Of Technology | Software |
| Year Produced | 2020 |
| Open Source License? | Yes |
| Impact | This software has been published in Nature Communications and is being used by external researchers in the field |
| URL | https://github.com/universe77/mr.ios |
| Description | A Multitude of Mendels |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | . Mendel @ 200. University of Bristol. Clifton Pavillion, Bristol Zoo, UK. 20th-21st July 2022. |
| Year(s) Of Engagement Activity | 2023 |
| Description | A press release 'New research finds GCSE results linked to child's enjoyment of school aged six'. |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | A child's enjoyment of school at six years old is linked to their GCSE results aged 16, according to new research from the University of Bristol, published in the journal Science of Learning. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.bristol.ac.uk/news/2021/june/childs-school-enjoyment.html |
| Description | A video on YouTube - 'I'm and epidemiologist' video with Institute for Research in Schools as a piece to include in IRIS teaching materials |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | 'I'm and epidemiologist' video with Institute for Research in Schools as a piece to include in IRIS teaching materials |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.youtube.com/watch?v=u0Bf3LwFyzQ |
| Description | Alcohol and Cardiovascular Disease. Aspirin Man: Celebrating the career of Professor Peter Elwood. University of Oxford, Oxford. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Lecture: Alcohol and Cardiovascular Disease. Aspirin Man: Celebrating the career of Professor Peter Elwood. University of Oxford, Oxford. Joint organization with John Gallacher (Oxford). |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.youtube.com/watch?v=mOdRbyA7NYk |
| Description | Alcohol and pregnancy |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | A quarter of adopted UK children affected by drinking during pregnancy. Survey by Adoption UK finds 17% of adopted children are suspected of having foetal alcohol spectrum disorder. Press release was distributed to 300 online outlets, including Radio 4 Today Programme, local BBC radio and TV news. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.theguardian.com/society/2020/sep/29/a-quarter-of-adopted-uk-children-affected-by-drinkin... |
| Description | Analogies between Mendelian randomization and natural selection. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Analogies between Mendelian randomization and natural selection. Seminar series: Institute of Evolutionary Medicine, Antwort, Zurich. 7th April 2021 |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.youtube.com/watch?v=LXnxpdfpNiM |
| Description | Being overweight throughout life increases risk of heart disease and diabetes |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Being overweight throughout life increases risk of heart disease and diabetes press release was covered in Press Association, Daily Express, Scotsman, Yahoo News, Yahoo News USA, TalkTalk, FarmWeek, Irish News, MedIndia, West Midlands Express, other regional media. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.irishnews.com/magazine/science/2020/05/06/news/being-overweight-throughout-life-increase... |
| Description | Black death genetics and COVID-19 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Publication of a paper in The American Journal of Human Genetics that showed that genes associated with surviving the Black Death continue to influence our mortality today and confer protection against respiratory diseases including COVID-19. Following the University of Bristol press release, the story was picked up by international media, including The Times, Medical Xpress, U.S. News and Mirage News. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.bristol.ac.uk/integrative-epidemiology/news/2023/genetic-variation-that-protected-agains... |
| Description | Blog - Does Schizophrenia Influence Cannabis Use? How to report the influence of disease liability on outcomes in Mendelian Randomization studies. - G Davey Smith |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Does Schizophrenia Influence Cannabis Use? How to report the influence of disease liability on outcomes in Mendelian Randomization studies. January 2019. https://targ.blogs.bristol.ac.uk/2019/01/07/does-schizophrenia-influence-cannabis-use-how-to-report-the-influence-of-disease-liability-on-outcomes-in-mendelian-randomization-studies/ |
| Year(s) Of Engagement Activity | 2018 |
| Description | Bristol Festival of Economics: Genoeconomics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | We hosted a panel discussion on genoeconomics as part of the Bristol Festival of Ideas. This even was well attended by a range of participants and had Neil Davies, George Davey Smith and Fleur Meddens on the panel. We discussed the implications of recent discoveries in genetic epidemiology for economics and social science more generally. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.ideasfestival.co.uk/events/genoeconomics/ |
| Description | COVID 19: Known unknowns webinar series |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 16 webinars took place online from November 2020 - November 2021 1. COVID 19: Known Unknowns: (Facing up to scientific uncertainty during a pandemic). University of Bristol/BMJ Webinar. 20th November 2020. Davey Smith G (main organiser), Godlee F (BMJ editor) https://www.youtube.com/watch?v=XtykvXKX1eM 2. COVID 19: Known Unknowns: Modelling. University of Bristol/BMJ Webinar. 30th November 2020. Davey Smith G (main organiser), Godlee F (BMJ editor), Pollock A (organiser) https://www.youtube.com/watch?v=qH7W6lWBIbo 3. COVID 19: Known Unknowns: Communicating uncertainty. University of Bristol/BMJ Webinar. Davey Smith G (main organiser), Godlee F (BMJ editor), Pollock A (organiser). 15th December 2020. https://www.youtube.com/watch?v=GQ5rOdUjCCo 4. COVID 19: Known Unknowns: Covid-19 and Schools. University of Bristol/BMJ Webinar. 28th January 2021. Davey Smith G (main organiser), Godlee F (BMJ editor) , Pollock A (organiser) https://www.youtube.com/watch?v=OOpH9mbiGnQ 5. COVID 19: Known Unknowns: Testing asymptomatic individuals for SARS-CoV-2-known unknowns. University of Bristol/BMJ Webinar. 11th February 2021. Davey Smith G (main organiser), Godlee F (BMJ editor), Pollock A (organiser) https://www.youtube.com/watch?v=L9Bq4sOnfQE 6. COVID 19: Known Unknowns: Vaccines. University of Bristol/BMJ Webinar. 25th February 2021. Davey Smith G, Godlee F, Cevik M (Organisers) https://www.youtube.com/watch?v=irSU3a_pVsA 7. COVID 19: Known Unknowns: Zero Covid. University of Bristol/BMJ Webinar. 11th March 2021. Davey Smith G, Pollock A, Doglee F, Cevik M (organisers) https://www.youtube.com/watch?v=HBd5Q8NpvoI (1.42.28) 8. COVID 19: Known Unknowns: New variants. University of Bristol/BMJ Webinar. 25th March 2021. Davey Smith G, Pollock A, Godlee F, Cevik M (organisers) https://www.youtube.com/watch?v=vsbOfWLWlU0 9. COVID 19: Known Unknowns: Long Covid. University of Bristol/BMJ Webinar. 15th April 2021 Davey Smith G, Pollock A, Godlee F (organisers) https://www.youtube.com/watch?v=2BeC_fVhAXs 10. COVID 19: Known Unknowns: Covid and Mental Health. University of Bristol/BMJ Webinar. 13th May 2021. Davey Smith G, Godlee F, Pollock A, Muanfo M (organisers) https://www.youtube.com/watch?v=Z8Taj1Bvnm8 11. COVID 19: Known Unknowns: Covid Passports and credentials. University of Bristol/BMJ Webinar. 10th June 2021. Davey Smith G, Godlee F, Pollock A (organisers) https://www.youtube.com/watch?v=BG3QG7Yza00 12. COVID 19: Known Unknowns: ageing and death in the time of covid. University of Bristol/BMJ Webinar. 9th July 2021. Davey Smith G, Smith R, Godlee F, Pollock A, (organisers) https://www.youtube.com/watch?v=JaCSZjuP5Uc 13. COVID 19: Known Unknowns: Vaccination in Children. University of Bristol/BMJ Webinar. 9th September 2021. Davey Smith G, Pollock A, Godlee F (organisers) https://www.youtube.com/watch?v=y6l9w3TIpyM 14. COVID 19: Known Unknowns: Origins of Covid. University of Bristol/BMJ Webinar. 7th October 2021. Davey Smith G, Pollock A, Godlee F (organisers) https://www.youtube.com/watch?v=eLSv4Iwk_jM 15. COVID 19: Known Unknowns: Population or Herd Immunity. University of Bristol/BMJ Webinar. 11th November 2021. Davey Smith G, Pollock A, Godlee F (organisers) https://www.youtube.com/watch?v=MOojHUFmB9Y 16. COVID 19: Known Unknowns: Zero COVID. University of Bristol/BMJ Webinar. 11th November 2021. Davey Smith G, Godlee F, Pollock A (organisers) https://www.youtube.com/watch?v=HBd5Q8NpvoI |
| Year(s) Of Engagement Activity | 2020,2021 |
| URL | https://www.bristol.ac.uk/integrative-epidemiology/outputs/known-unknowns/ |
| Description | Chance as the fundamental element in epidemiological thinking. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Chance as the fundamental element in epidemiological thinking. Randomness in Medicine. KNAW Webinar, Netherlands. 26th October 2021. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.youtube.com/watch?v=SQRhZOWYGQY |
| Description | Children of the 90s. 30 years of Bristol's world-leading birth cohort study |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Children of the 90s. 30 years of Bristol's world-leading birth cohort study. University of Bristol. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.youtube.com/watch?v=gCef9uMjt14 |
| Description | Comment on covid death statistics |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Comment on covid death statistics press release covered in Press Association, Daily Express, Scotsman, Yahoo News, Yahoo News USA, TalkTalk, FarmWeek, Irish News, MedIndia, West Midlands Express, other regional media. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.sciencemediacentre.org/expert-reaction-to-latest-ons-stats-on-deaths-in-england-and-wale... |
| Description | Epidemiology and covid-19 for year 6 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Online public engagement event on epidemiology and covid-19 for 20 year 6 pupils at Horfield School and three sessions at Nova Primary School. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Even low alcohol consumption is bad news for strokes |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | News artical in the following publications Guardian, CNN, BBC, Medical News Today, USA Today, Daily Mail, Telegraph, Scotsman, Sun, Star, Web MD, Daily Sabah, Irish Independent, USA Today etc |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.theguardian.com/society/2019/apr/04/even-low-booze-consumption-is-bad-news-for-strokes-s... |
| Description | FUTURES |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | FUTURES 'meet the researcher' event organised by University of Bristol central public engagement team |
| Year(s) Of Engagement Activity | 2020 |
| URL | http://www.bristol.ac.uk/public-engagement/engagement-opportunities/futures/ |
| Description | FUTURES event with stands from UoB STEM researchers, including IEU toolkits (Question generator, Sample sizer, Wheel of Fortune, Chromosome) and ALSPAC activities. Part of European Researchers' Night organised by central PE team. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | FUTURES event with stands from UoB STEM researchers, including IEU toolkits (Question generator, Sample sizer, Wheel of Fortune, Chromosome) and ALSPAC activities. Part of European Researchers' Night organised by central PE team. |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.bristol.ac.uk/integrative-epidemiology/news/2019/futures-2019.html |
| Description | Fundamental principles of Mendelian randomization. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Fundamental principles of Mendelian randomization. Benevolent Fund Seminar in Oxford on 29th October 2021 |
| Year(s) Of Engagement Activity | 2021 |
| Description | G=E: how Mendelian?randomization can help identify?modifiable causes of disease. UK Eye Genetics. The Watershed, Bristol, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Lecture - G=E: how Mendelian randomization can help identify modifiable causes of disease. UK Eye Genetics. The Watershed, Bristol, UK. 17th June 2022. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Height, leg and trunk length and health outcomes: some work in progress. NTNU, Trondheim. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Lecture: Height, leg and trunk length and health outcomes: some work in progress. NTNU, Trondheim. 17th February 2023 |
| Year(s) Of Engagement Activity | 2023 |
| Description | How Do We Know if Alcohol Is Bad for Us?. Freakonomics MD. |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | How Do We Know if Alcohol Is Bad for Us?. Freakonomics MD. 24th May 2022 |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://freakonomics.com/podcast/how-do-we-know-if-alcohol-is-bad-for-us/ |
| Description | Human genetics and genetic?epidemiology in drug development. Mendelian randomization:?Past, present and future. Mendelian randomization in Drug Development Seminar. Oxford, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Lecture: Human genetics and genetic epidemiology in drug development. Mendelian randomization: Past, present and future. Mendelian randomization in Drug Development Seminar. Oxford, UK. 8th June 2022. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Human genetics and phenotypic causality: A Historical Introduction. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Human genetics and phenotypic causality: A Historical Introduction. Lorentz Center, Leiden, The Netherlands. 13th December 2021. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Human genetics and phenotypic causality: An historical introduction. University College London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited lecture: "Natural selection is through phenotype, thus the issue of phenotypic causality has been central to evolutionary and genetic thought in their modern (i.e. post-1850s) formulations. The rediscovery of Mendel's work at the turn of the 20th Century provided a potential mechanism integrating the two, as reflected in the work of George Udny Yule, John Brownlee, Edward East and others. This culminated in RA Fisher's (not generously referenced/ footnoted) 1918 paper. Sewall Wright introduced an analogous framework simultaneously with Fisher, together with the entirely original formulation of path analyses as a causal analytical strategy when reliable causal anchors were available. Wright also contributed to his father's introduction of the instrumental variable framework in 1928, though did not link this to his work on genetics and phenotypic causality. In the mid-20th Century Fisher related thinking about randomization in agricultural studies to the factorial randomization of Mendelian genes. Occasional informal uses of genetics to strengthen inference on phenotypic causation in humans was seen from the 1960s onwards. The term Mendelian randomization was introduced by Richard Gray and Keith Wheatley in 1991 when proposing a method using family relatedness to provide evidence of effectiveness of bone marrow transplant in hematopoietic malignancies. The term was used for studies of the kind today recognized as MR from the early 2000s on. Echoing the development of Wright's work, neither the term, nor the concept, was influenced in any way by instrumental variable analysis. For making inferences on phenotypic causality - both in evolutionary and epidemiological settings - the key assumption is of gene-environmental equivalence, which should be the starting point for any serious consideration of the approach. George Davey-Smith delivered this seminar at at University College, London on 16 March 2022. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.youtube.com/watch?v=C922iH_y3lM&t=4s |
| Description | I am a genetic scientist - Year 6 engagement |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Four researchers visited a primary school in a low socio-economic status area of Bristol and engaged 180 pupils from years 2 to 6 in a range of hands-on and interactive sessions. Researchers reported they found it stimulating to thing about key messages that would be relevant to younger children. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Identifying risk factors using Mendelian randomization. Evidence Based Management of Cancers in India |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Identifying risk factors using Mendelian randomization. Evidence Based Management of Cancers in India, TATA Memorial Centre XXI Annual Conference. 24th February 2023. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Introductory Mendelian Randomization Workshop. Public Health Grand Rounds. UCLA Fielding School of Public Health, Los Angeles. 31st May 2019. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Mendelian randomization (MR) utilizes the particular properties of germline genetic variation to strengthen causal inference with respect to modifiable influences on health, disease and social outcomes. This session will present the assumptions required for MR and the ever-expanding range of sensitivity analyses and falsification strategies that are available. Hypothesis-free causal search strategies based on MR will be briefly touched upon, as will the application of MR to molecular and tissue-specific phenotypes. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://ph.ucla.edu/events/dept-epidemiology-introductory-mendelian-randomization-workshop |
| Description | Launch of new blog on causality in population health |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | IEUREKA! is for blog posts on causality in population health from the MRC Integrative Epidemiology Unit. It provides IEU researchers with a platform to synthesis research findings into short articles and discussion pieces and to express their views on current public interest topics. We aim to reach the wider public. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://ieureka.blogs.bristol.ac.uk/ |
| Description | MR and the BMI / bone mineral density / osteoporosis / fracture Nexus. Relation RX, 30th May 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited lecture: MR and the BMI / bone mineral density / osteoporosis / fracture Nexus. Relation RX, 30th May 2022. |
| Year(s) Of Engagement Activity | 2022 |
| Description | MR: where did it come from? GENMED Workshop, Pasteur Institute, Paris |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | MR: where did it come from? GENMED Workshop, Pasteur Institute, Paris. 20th September 2022 |
| Year(s) Of Engagement Activity | 2022 |
| Description | Mendelian Randomization Workshop. University Medical Centre, Groningen. 14th October 2019. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | This workshop will cover issues relevant to applied causal inference in epidemiology, building on practical examples across diverse fields. The value of formal approaches to quantitative causal inference will be explored in the context of such practical examples. The use of falsification methods (including negative control exposures & outcomes and cross-context comparisons) and the harnessing of external perturbations (including formal instrumental variables analyses) will be discussed. A triangulation approach based on a pre-specified set of methods - each which may be biased, but with biases anticipated to be near-orthogonal - will be advanced. The notion that causal inference will always be a joint qualitative and quantitative activity, and that quantification of causal estimates should go as far as is useful, but no further, will be defended. The focus will be mainly on non-genetic approaches to causal inference, as a second workshop will cover Mendelian randomization in detail. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.rug.nl/aletta/calendar/workshop-george-davey-smith---triangulation-of-evidence-and-causa... |
| Description | Mendelian randomization across life and between tissues: Some speculative new approaches. CHARGE Consortium. University of Pennsylvania, USA. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Lecture: Mendelian randomization across life and between tissues: Some speculative new approaches. CHARGE Consortium. University of Pennsylvania, USA. 29th April 2022. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Mendelian randomization and pharmacotherapeutics. 23andMe |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited lecture: Mendelian randomization and pharmacotherapeutics. 23andMe. 1st June 2022 |
| Year(s) Of Engagement Activity | 2022 |
| Description | Mendelian randomization for African scientists |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Six researchers from the MRC IEU organised a five-day course on Mendelian randomization to African researchers in Kilifi. The aim was to teach participants how to implement Mendelian randomization (MR) and how to use the IEU-developed and open-source MR-Base software platform. The UK researchers and the African scientists also spent time talking about their own research interests, stimulating potential future collaborations. Participant feedback was extremely positive with participants leaving with the skills and knowledge to apply MR in their own research. Some individuals are now planning research visits to the UK, with one having since secured a visiting fellowship and another has made a funding application. Most significant impact: change in views, behaviours, opinions |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://ieureka.blogs.bristol.ac.uk/2023/01/27/genetic-epidemiology-african-scientists/ |
| Description | Mendelian randomization in hypertension research: what can it add? |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Mendelian randomization in hypertension research: what can it add? European Society of Hypertension (ESH) and International Society of Hypertension (ISH). 14th April 2021. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Mendelian randomization. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Mendelian randomization. Takeda Pharmaceuticals, Cambridge USA. 2nd December 2021 |
| Year(s) Of Engagement Activity | 2021 |
| Description | Mendelian randomization: strengthening causal inference in observational data by using genetic anchors. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Nuffield Department of Population Health MSc in Global Health Science Masterclass. Mendelian randomization: strengthening causal inference in observational data by using genetic anchors. Nuffield Department of Population Health, Oxford. 18th May 2022. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Mendelian randomization: what (if anything) can it add to covid-19 research? |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Mendelian randomization: what (if anything) can it add to covid-19 research? Harvard TH Chan School of Public Health 2021 PQG Conference, USA. 28th October 2021 |
| Year(s) Of Engagement Activity | 2021 |
| Description | Methods for strengthening causal interference in examining mediation between socioeconomic position and health outcomes. Do we need a better data base for research on social inequality in health, education, welfare and democratic participation? |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor George Davey Smith attending this presentation in Norway on 'Methods for strengthening causal interference in examining mediation between socioeconomic position and health outcomes. Do we need a better data base for research on social inequality in health, education, welfare and democratic participation? This raised the profile of his research at University of Bristol. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://videoportal.rcn.no/#/videos/b65c1186-c423-40ec-9c93-f2d5e5f6f473 |
| Description | Modern or Modish Epidemiology? What is Lost When Fashions Change. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Modern or Modish Epidemiology? What is Lost When Fashions Change. Department of Epidemiology at the Johns Hopkins Bloomberg School of Public Health. 17th May 2021. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.youtube.com/watch?v=igjBBhyhPvM |
| Description | News articles about research: Higher education reduces the risk of heart attack |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | News coverage in the following newspaper; Daily Mail (UK), Daily Telegraph, Classic 105, Siasat Daily, Asian News International, Devdiscourse, New Kerala, Web India 123, Ani News, Business Standard India, New Delhi News, World News Update, Pulse Today, MSN Philippines |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.dailymail.co.uk/health/article-7058455/The-longer-spend-education-likely-overweight-unhe... |
| Description | Our genetic inheritance - engagement with Year 6 pupils |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Four researchers attended a primary school in a low socio-economic area of Bristol to engage with 50 pupils on the subject of 'our genetic inheritance'. The pupils and teachers reported that the event consolidated pupil's learning, discussions were challenging, and it engaged all the pupils. Researchers reported they valued the experience to connect with children and pass on some fun and interesting learning. The school have requested further visits. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Part of MRC Festival of Medical Research - talks from researchers about their work, followed by conversations |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Talks from researchers about their work, followed by conversations at the Friendly Club, Westbury on Trym |
| Year(s) Of Engagement Activity | 2019 |
| Description | Part of MRC Festival of Medical Research - very short talks from researchers about their work, followed by carousel of 4 toolkit activities |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Very short talks from researchers about their work, followed by carousel of 4 toolkit activities at St Pius RC Primary School, Withywood |
| Year(s) Of Engagement Activity | 2019 |
| Description | Part of MRC Festival of Medical Research - very short talks from researchers about their work, followed by carousel of 4 toolkit activities |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Very short talks from researchers about their work, followed by carousel of 4 toolkit activities at the Nova Primary School, Avonmouth |
| Year(s) Of Engagement Activity | 2019 |
| Description | Paul Garner Valdictorian. Truth not Triumph: backstage at Cochrane Infectious Diseases. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Paul Garner Valedictory. Truth not Triumph: backstage at Cochrane Infectious Diseases. LSHTM, Liverpool. 8th September 2022 |
| Year(s) Of Engagement Activity | 2023 |
| Description | Pint of Science in Bristol |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Industry/Business |
| Results and Impact | Talk in local pub in Bristol on Nature versus Nutrition |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://pintofscience.co.uk/city/bristol |
| Description | Pre-registered triangulation of evidence. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Pre-registered triangulation of evidence. CAUSALab Seminar Series. Harvard School of Public Health, Boston, USA. 23rd November 2021 |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.youtube.com/watch?v=-0XxYEjhHZ4 |
| Description | Pre-registered triangulation of evidence. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Pre-registered triangulation of evidence. Broad Institute, Boston USA. 2nd December 2021. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Pre-registered triangulation of evidence: The role of birth cohorts. 1st Open MoBa Research Forum |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Lecture: Pre-registered triangulation of evidence: The role of birth cohorts. 1st Open MoBa Research Forum. Norway, Oslo. 29th September 2022. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Predictive, personalised, preventive and participatory medicine: what is possible. Quantitative Health Sciences Grand Rounds. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Predictive, personalised, preventive and participatory medicine: what is possible. Quantitative Health Sciences Grand Rounds. Mayo Clinic. 12th July 2021. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Predictive, personalised, preventive?and participatory medicine: what is?possible?. Quantitative Health Sciences Grand Rounds, Mayo Clinic, USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited Lecture: Predictive, personalised, preventive and participatory medicine: what is possible?. Quantitative Health Sciences Grand Rounds, Mayo Clinic, USA. 13th June 2022. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation at Academy of Medical Sciences Mentoring Scheme - G Davey Smith |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Professor George Davey Smith gave a presentation at Early Career Team Scientist. Succeeding in Team Science: Collaboration, recognition and leadership in London in May 2018. This talk raised the profile of Professor Davey Smith and his research. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation at American Society of Human Genetics - G Davey Smith |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor George Davey Smith was invited to present at the American Society of Human Genetics. San Diego, California. Talk entitled "Mendelian randomization and disease progression: Challenges and opportunities". October 2018. This talk raised the profile of Professor Davey Smith and his research. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation at Montreal Neurological Institute and Hospital - G Davey Smith |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor George Davey Smith was invited to present at the Montreal Neurological Institute and Hospital, McGill University. The Genome Centre. Montreal on "Mendelian Randomization: some unresolved issues". 7th September 2018. This talk raised the profile of Professor Davey Smith and his research. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation at Norwegian Epidemiology Association's conference - G Davey Smith |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor George Davey Smith was invited to present at the Norwegian Epidemiology Association's conference. Trondheim. 15th November 2018. Title "Mendelian Randomization and the potential of genetics to inform causality" This talk raised the profile of Professor Davey Smith and his research. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation at Open Targets Integration Meeting - G Davey Smith |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor George Davey Smith was invited to be present at the Open Targets Integration Meeting. Hinxton on "Mendelian randomization: an update". June 2018. This talk raised the profile of Professor Davey Smith and his research. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation at Opening Symposium Centre for Fertility and Health - G Davey Smith |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor George Davey Smith was invited to give a talk on "Can genetics contribute to the study of fertility and health? Opening Symposium Centre for Fertility and Health. Oslo. May 2018. This talk raised the profile of Professor Davey Smith and his research. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation at Statens Institute for Folkesundhed. Copenhagen - G Davey Smith |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor George Davey Smith was invited to give a presentation on "Triangulation of evidence: strengthening causal inference in observational epidemiology" at the Statens Institute for Folkesundhed. April 2018 This talk raised the profile of Professor Davey Smith and his research. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation at University of California - G Davey Smith |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor George Davey Smith was invited to present at the University of California, USA. Title of talk "Using genetics to understand modifiable behavioural, social and physiological causes of disease". October 2018. This talk raised the profile of Professor Davey Smith and his research. This talk raised the profile of Professor Davey Smith and his research. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation at the Bristol Poverty Institute. Fifth Peter Townsend Memorial Conference - G Davey Smith |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor George Davey Smith was invited to present at the Bristol Poverty Institute, Fifth Peter Townsend Memorial Conference. University of Bristol. November 2018. Title "Causal Analysis of Social Inequalities in Health". This talk raised the profile of Professor Davey Smith and his research. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation at the Common Disease Meeting - G Davey Smith |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor George Davey Smith was invited to give a presentation at the Common Disease Meeting. Oxford, UK. Title "G=E, GrE and GxE: opportunities for epidemiology". This talk raised the profile of Professor Davey Smith and his research. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation at the Norwegian Institute of Public Health - G Davey Smith |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor George Davey Smith was invited to give a presentation titled "What Epidemiologists and Demographers can learn from each other: An Epidemiologist's Perspective" at The Norwegian Institute of Public Health. Oslo. May 2018. This talk raised the profile of Professor Davey Smith and his research. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation at the University of Bristol - G Davey Smith |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor George Davey Smith was invited to present at the SRSM2018 Pre-conference workshop: Causal Inference for Research Synthesis. University of Bristol, Bristol. July 2018. This talk raised the profile of Professor Davey Smith and his research. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presented Precision Medicine Webinar - G Davey Smith |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Asked to present "What is Mendelian Randomization and How Can it be Used as a Tool for Medicine and Public Health? Opportunities and Challenges". For the Precision Medicine Webinar. 27th November 2018. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.youtube.com/watch?v=pc3uQz06gO8&feature=youtu.be&app=desktop |
| Description | Radio 4 Analysis with Michael Blastland?: Finding things out |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Radio 4 Analysis with Michael Blastland : Finding things out. 15th November 2021 https://www.bbc.co.uk/sounds/play/m0011l1g (7.45) |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.bbc.co.uk/sounds/play/m0011l1g |
| Description | Radio 4 Analysis: Finding things out. |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Radio 4 Analysis: Finding things out. 15th November 2021 |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.bbc.co.uk/sounds/play/m0011l1g |
| Description | Some constraints on the scope and potential of personalized medicine |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Some constraints on the scope and potential of personalized medicine. NTNU Trondheim. 29th October 2021. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://ntnu.cloud.panopto.eu/Panopto/Pages/Viewer.aspx?id=44cf4607-91fe-4012-9af0-add000ee148c |
| Description | Stand in Einstein's Garden including 15 giant stuffed chromosomes to decorate and IEU toolkits (Question generator, Sample sizer, Wheel of Fortune, Mystery Box, Confounders) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Stand in Einstein's Garden including 15 giant stuffed chromosomes to decorate and IEU toolkits (Question generator, Sample sizer, Wheel of Fortune, Mystery Box, Confounders) |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.bristol.ac.uk/integrative-epidemiology/news/2019/green-man-2019.html |
| Description | The 6th Cutter Symposium: Epidemiology and Causes. "Ubiquitous Causes: Can They Be Identified?" Harvard T.H. Chan, School of Public Health, USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Lecture: The 6th Cutter Symposium: Epidemiology and Causes. "Ubiquitous Causes: Can They Be Identified?" Harvard T.H. Chan, School of Public Health, USA. 6th May 2022 |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.youtube.com/watch?v=l3qG9BV-GAo |
| Description | Triangulation and Mendelian randomization |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Triangulation and Mendelian randomization. Standing Committee on Evidence Synthesis, and Communications in Diet and Chronic Disease Relationships" National Academy of Sciences, Engineering and Medicine. 24th March 2021 |
| Year(s) Of Engagement Activity | 2021 |
| Description | Triangulation of evidence and causal inference in epidemiology workshop. University Medical Centre, Groningen. 16th October 2019. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Triangulation of evidence and causal inference in epidemiology workshop. University Medical Centre, Groningen. 16th October 2019. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Triangulation of evidence and causal inference. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Triangulation of evidence and causal inference. Joint Biosecurity Centre. Department of Health and Social Care in London on 4th August 2021 |
| Year(s) Of Engagement Activity | 2021 |
| Description | Triangulation of evidence in aetiological epidemiology: principles, prospects, limitations. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Triangulation of evidence in aetiological epidemiology: principles, prospects, limitations. Richard Doll Seminar, University of Oxford, UK. 21st February 2023 |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://tv.ndph.ox.ac.uk/events/ |
| Description | Using Mendelian randomization for drug target validation. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Lecture: Using Mendelian randomization for drug target validation. Insitro, USA 13th February 2023. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Using Mendelian randomization for drug target validation. Insitro, USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Lecture: Using Mendelian randomization for drug target validation. Insitro, USA. 13th February 2023. |
| Year(s) Of Engagement Activity | 2023 |
| Description | What if the exposures are ubiquito |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Environment and Health: What if the exposures are ubiquitous? Bristol Inspired Event. 24th February 2023. |
| Year(s) Of Engagement Activity | 2023 |