Epigenetic Epidemiology
Lead Research Organisation:
University of Bristol
Department Name: UNLISTED
Abstract
This programme aims to gain a better understanding of the determinants and consequences of epigenetic variation through the use of epidemiological approaches. We will extend our knowledge of the relationship between common genetic variation and DNA methylation across the genome through large scale GWAS analysis. The identification of genetic variants that tag methylation variation will enhance our ability to conduct Mendelian randomization to strengthen causal inference. We will develop our use of DNA methylation as a biomarker of disease prediction and prognosis as well as an index of exposure to disease risk factors. Lastly, we will combine these elements of the programme and other methodological advances in epigenetic epidemiology to address a variety of disease specific research questions.
Technical Summary
Background: To maximally exploit the rapid pace of change, including the accrual of large-scale data, in the field of epigenetic epidemiology, we will develop innovative methods for the robust scientific interrogation of population-based epigenetic data and apply them to research questions of scientific and medical importance, structured around four domains:
Aim 1: We will explore the genetic architecture of epigenetic traits and use this information to understand the role that DNA methylation variation plays in health and disease.
Aim 2: We will develop and make readily accessible the causal analysis methods and tools and apply Mendelian randomization (MR) to epigenetic questions.
Aim 3: We will use DNA methylation as an index of past exposures to improve our prediction of disease risk and prognosis.
Aim 4: From neurodevelopment to cancer, there are a multitude of settings in which we can apply epigenetic epidemiology to understand disease mechanisms and predict disease.
Methods: We will utilize multiple data sources; from in-house studies, via collaborations and consortia, and through publicly accessible repositories. Our primary focus will be on the analysis of DNA methylation, as this continues to be the most readily available source of epigenetic data in population-based studies. However, we will integrate these data with newly generated and publicly available epigenomic and transcriptomic data, tissue-specific data and histone modification data.
A wide range of methods will be applied. These include mQTL analysis, functional annotation and machine learning approaches, such as penalized regression, support vector machines, and neural networks. We will test for mediation using MR and apply our prediction methods in disease relevant datasets.
Translation: The output arising from this programme will be used to develop biomarkers of disease risk and disease prognosis. It will also shed light on the genetic architecture of DNA methylation and the causal role this molecular phenotype plays in development and disease, which will in turn inform future interventions.
Aim 1: We will explore the genetic architecture of epigenetic traits and use this information to understand the role that DNA methylation variation plays in health and disease.
Aim 2: We will develop and make readily accessible the causal analysis methods and tools and apply Mendelian randomization (MR) to epigenetic questions.
Aim 3: We will use DNA methylation as an index of past exposures to improve our prediction of disease risk and prognosis.
Aim 4: From neurodevelopment to cancer, there are a multitude of settings in which we can apply epigenetic epidemiology to understand disease mechanisms and predict disease.
Methods: We will utilize multiple data sources; from in-house studies, via collaborations and consortia, and through publicly accessible repositories. Our primary focus will be on the analysis of DNA methylation, as this continues to be the most readily available source of epigenetic data in population-based studies. However, we will integrate these data with newly generated and publicly available epigenomic and transcriptomic data, tissue-specific data and histone modification data.
A wide range of methods will be applied. These include mQTL analysis, functional annotation and machine learning approaches, such as penalized regression, support vector machines, and neural networks. We will test for mediation using MR and apply our prediction methods in disease relevant datasets.
Translation: The output arising from this programme will be used to develop biomarkers of disease risk and disease prognosis. It will also shed light on the genetic architecture of DNA methylation and the causal role this molecular phenotype plays in development and disease, which will in turn inform future interventions.
Organisations
- University of Bristol (Lead Research Organisation)
- Copenhagen University Hospital (Collaboration)
- GenExp (Collaboration)
- University of Surrey (Collaboration)
- Technical University of Munich (Collaboration)
- Federal Ministry for the Environment, Nature Conservation and Nuclear Safety (BMU) (Collaboration)
- Norwegian University of Science and Technology (NTNU) (Collaboration)
- GECKO Drenthe Birth Cohort (Collaboration)
- Center for Environmental Research and Children's Health (Collaboration)
- Leiden University Medical Center (Collaboration)
- EMBL European Bioinformatics Institute (EMBL - EBI) (Collaboration)
- Columbia Center for Children's Environmental Health (Collaboration)
- University of Bath (Collaboration)
- Norwegian Institute of Public Health (Collaboration)
- Project Viva (Collaboration)
- Ludwig Maximilian University of Munich (LMU Munich) (Collaboration)
- Oslo University Hospital (Collaboration)
- Medical Research Council (MRC) (Collaboration)
- Finnish Birth Cohort (Collaboration)
- UNIVERSITY OF ESSEX (Collaboration)
- HARVARD UNIVERSITY (Collaboration)
- Bristol City Council (Collaboration)
- Erasmus MC (Collaboration)
- GW4 (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
- UNIVERSITY OF EXETER (Collaboration)
- UNIVERSITY OF OXFORD (Collaboration)
- Wageningen University & Research (Collaboration)
- PRISMA ONG (Collaboration)
- GLYNDWR UNIVERSITY (Collaboration)
- International Agency for Research on Cancer (IARC) (Collaboration)
- GenR (Collaboration)
- London School of Hygiene and Tropical Medicine (LSHTM) (Collaboration)
- Federal University of Pelotas (UFPel) (Collaboration)
- UNIVERSITY OF EDINBURGH (Collaboration)
- University of Toronto (Collaboration)
- National Institutes of Health (NIH) (Collaboration)
- National Institute of Environmental Health Sciences (Collaboration)
- UNIVERSITY OF BRITISH COLUMBIA (Collaboration)
- VCE Mobile & Personal Comm Ltd (Collaboration)
- KING'S COLLEGE LONDON (Collaboration)
- Government of Canada (Collaboration)
- North-West University (Collaboration)
- University College Dublin (Collaboration)
- University at Buffalo (Collaboration)
- University of Southern Denmark (Collaboration)
- Kiel University (Collaboration)
- Barcelona Institute for Global Health (Collaboration)
- Rutherford Appleton Laboratory (Collaboration)
- Cardiff University (Collaboration)
- Stellenbosch University (Collaboration)
- National Institute of Standards & Technology (NIST) (Collaboration)
- University of Bristol (Collaboration)
- University College London (Collaboration)
- University of Manchester (Collaboration)
- National Health Service (Collaboration)
- University of Western Australia (Collaboration)
- European Association for Research on Learning and Instruction (EARLI) (Collaboration)
- University of California, Los Angeles (UCLA) (Collaboration)
- Inmarsat (Collaboration)
- University of the West of England (Collaboration)
- University of Memphis (Collaboration)
- European Huntington's Disease Network (Euro-HD) (Collaboration)
- ITS (United Kingdom) (Collaboration)
- MTT Ltd Machine Tools Technologies (Collaboration)
- New Hampshire Birth Cohort Study (Collaboration)
- Progressive Energy Ltd (Collaboration)
- Rhode Island Child Health Study (Collaboration)
People |
ORCID iD |
Publications
Russell AE
(2020)
Investigating evidence for a causal association between inflammation and self-harm: A multivariable Mendelian Randomisation study.
in Brain, behavior, and immunity
Hulls Paige M.
(2020)
DNA methylation signature of passive smoke exposure is less pronounced than active smoking: The
Understanding Society study
in ENVIRONMENTAL RESEARCH
Golding J
(2020)
Grandchild's IQ is associated with grandparental environments prior to the birth of the parents.
in Wellcome open research
Richardson TG
(2020)
A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome.
in Nature communications
Cronjé HT
(2020)
Replication and expansion of epigenome-wide association literature in a black South African population.
in Clinical epigenetics
Langdon R
(2020)
Identifying epigenetic biomarkers of established prognostic factors and survival in a clinical cohort of individuals with oropharyngeal cancer.
in Clinical epigenetics
Parker K
(2020)
The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits
in Genes
Robinson T
(2020)
Mendelian randomisation analysis of circulating adipokines and C-reactive protein on breast cancer risk.
in International journal of cancer
Sharp TH
(2020)
Population neuroimaging: generation of a comprehensive data resource within the ALSPAC pregnancy and birth cohort.
in Wellcome open research
Li L
(2020)
Pubertal onset with adulthood lung function mediated by height growth in adolescence.
in ERJ open research
Golding J
(2020)
Ancestral childhood environmental exposures occurring to the grandparents and great-grandparents of the ALSPAC study children.
in Wellcome open research
Vehmeijer FOL
(2020)
DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies.
in Genome medicine
Kazmi N
(2020)
Associations between high blood pressure and DNA methylation.
in PloS one
Surendran P
(2020)
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.
in Nature genetics
Wootton RE
(2020)
Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: a Mendelian randomisation study.
in Psychological medicine
English S
(2020)
Prenatal anxiety, breastfeeding and child growth and puberty: linking evolutionary models with human cohort studies.
in Annals of human biology
Marini S
(2020)
Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children.
in Psychoneuroendocrinology
Jamieson E
(2020)
Smoking, DNA Methylation, and Lung Function: a Mendelian Randomization Analysis to Investigate Causal Pathways.
in American journal of human genetics
Russell A
(2021)
Childhood adversity, pubertal timing and self-harm: a longitudinal cohort study
in Psychological Medicine
Van Dongen J
(2021)
Identical twins carry a persistent epigenetic signature of early genome programming.
in Nature communications
Related Projects
| Project Reference | Relationship | Related To | Start | End | Award Value |
|---|---|---|---|---|---|
| MC_UU_00011/1 | 01/04/2018 | 31/03/2023 | £2,864,000 | ||
| MC_UU_00011/2 | Transfer | MC_UU_00011/1 | 01/04/2018 | 31/03/2023 | £965,000 |
| MC_UU_00011/3 | Transfer | MC_UU_00011/2 | 01/04/2018 | 31/03/2023 | £1,011,000 |
| MC_UU_00011/4 | Transfer | MC_UU_00011/3 | 01/04/2018 | 31/03/2023 | £1,329,000 |
| MC_UU_00011/5 | Transfer | MC_UU_00011/4 | 01/04/2018 | 31/03/2023 | £1,254,000 |
| MC_UU_00011/6 | Transfer | MC_UU_00011/5 | 01/04/2018 | 31/03/2023 | £1,640,000 |
| MC_UU_00011/7 | Transfer | MC_UU_00011/6 | 01/04/2018 | 31/03/2023 | £1,083,000 |
| Description | 1001 Critical Days consultation |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| URL | https://epoch.blogs.bristol.ac.uk/2020/02/04/the-1001-critical-days-movement/ |
| Description | COVID response |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | I have contributed to the Bristol City Council Health Protection Advisory Group and chair the University of Bristol COVID-19 Scientific Advisory Group. Both are concerned with synthesis of evidence to support COVID response in the University, city and region. This has included a twice monthly institutional risk assessment involving city of Bristol Public Health colleagues, UK HSA and the University management. |
| Description | Co-director of the MSc in Reproduction and Development |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Gemma Sharp is the co-director of the University of Bristol's highly successful MSc in Reproduction and Development. Students include practicing midwifes, junior doctors, researchers and embryologists. The course equips them with the necessary skills to improve their practice and critically appraise, design and conduct relevant research. |
| URL | http://www.bristol.ac.uk/medical-school/study/postgraduate/reproduction-development/ |
| Description | Genetic and Epigenetic Epidemiology (EEPE) course |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Gemma Sharp and Rebecca Richmond (along with David Evans and Gib Hemani) co-developed and delivered a one week course on genetic and epigenetic epidemiology in Florence. Participants ranged from masters to professorial level. The course was very well-received and participants reported feeling confident that they had achieved the intended learning outcomes. Several are now conducting their own genetic/epigenetic studies. |
| URL | https://eepe.org/courses/ |
| Description | Lectures at LSHTM |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Gemma Sharp was invited to give two lectures to masters students at the London School of Hygiene and Tropical Medicine: "Minimising bias and confounding in observational epidemiology" and "Mendelian Randomization". These will take place on March 17th 2020. The lectures are intended to introduce students to these important areas and methods in observational epidemiology and equip them with the skills to critically appraise, design and conduct high quality epidemiological research. |
| Description | MSc in Epidemiology - unit lead of 'Molecular Epidemiology for Noncommunicable Disease' |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Gemma Sharp co-developed from scratch and now co-delivers a unit on Molecular Epidemiology as part of the University of Bristol's MSc in Epidemiology. The unit introduces masters students to molecular (genetic and epigenetic) epidemiology and equips them with the skills to critically appraise, design and conduct high quality epidemiological research. |
| URL | https://www.bris.ac.uk/unit-programme-catalogue/UnitDetails.jsa;jsessionid=2BBAB6E8979AB5B406936FBF3... |
| Description | WRISK project expert panel - Gemma Sharp |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| URL | https://threadreaderapp.com/thread/1220645863577485312.html |
| Description | Workshop on harmonisation of data in multicohort studies |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Gemma Sharp gave a talk as part of a half-day course on data harmonization in observational studies at the DOHaD 2019 world congress in Melbourne. Participants ranged from masters to professorial level. The course was very well-received and participants reported feeling confident that they had achieved the intended learning outcomes. Several are now conducting their own multi cohort studies. |
| URL | http://www.cvent.com/events/2019-dohad-international/custom-132-828d23c3caf043c0ae6449de8d7bfbc3.asp... |
| Description | Workshop on triangulation |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Gemma Sharp co-developed and delivered a half-day course on triangulation in observational studies at the DOHaD 2019 world congress in Melbourne. Participants ranged from masters to professorial level. The course was very well-received and participants reported feeling confident that they had achieved the intended learning outcomes. Several are now conducting their own triangulation studies. |
| URL | http://www.cvent.com/events/2019-dohad-international/custom-132-828d23c3caf043c0ae6449de8d7bfbc3.asp... |
| Description | COVID-19 Mapping and Mitigation in Schools (CoMMinS) |
| Amount | £2,817,666 (GBP) |
| Funding ID | MR/V028545/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2020 |
| End | 08/2021 |
| Description | Creating a West African BioResource for Nutritional Genetics and Epigenetics (C Relton) |
| Amount | £186,171 (GBP) |
| Funding ID | MC_PC_MR/R020183/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 12/2018 |
| Description | De Pass Vice Chancellor's Fellowship - Rebecca Richmond |
| Amount | £260,000 (GBP) |
| Organisation | University of Bristol |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 10/2022 |
| Description | Does epigenetic methylation explain the gender-switch in adolescent asthma? |
| Amount | $3,137,380 (USD) |
| Organisation | National Institutes of Health Clinical Center |
| Sector | Hospitals |
| Country | United States |
| Start | 01/2016 |
| End | 01/2021 |
| Description | EPIC DIVE - Early PancreatIc Cancer Diagnosis In Vivo Evaluation |
| Amount | £228,000 (GBP) |
| Funding ID | EDDISA-Jan22\100004 |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2022 |
| End | 12/2023 |
| Description | ERA-HDHL - Early life programming of childhood health: a nutritional and epigenetic investigation of adiposity and bone, cardiometabolic, neurodevelopmental and respiratory health. |
| Amount | £124,600 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2017 |
| End | 12/2019 |
| Description | FDS RCSEng - British Association of Oral Surgeons grant |
| Amount | £10,000 (GBP) |
| Organisation | British Association of Oral and Maxillofacial Surgeons |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2021 |
| End | 06/2022 |
| Description | GW4 Generator Award |
| Amount | £14,800 (GBP) |
| Organisation | GW4 |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 06/2021 |
| End | 11/2021 |
| Description | GW4 Neurodevelopmental neurodiversity network |
| Amount | £18,200 (GBP) |
| Organisation | GW4 |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 04/2020 |
| End | 03/2024 |
| Description | HDR UK RCUK Innovation/Rutherford Fellowships - Two fellowships (C Relton) |
| Amount | £614,457 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2018 |
| End | 01/2021 |
| Description | NIH - Childhood adversity, DNA methylation and risk for depression: A longitudinal study of sensitive periods in development. |
| Amount | $1,623,764 (USD) |
| Organisation | National Institutes of Health (NIH) |
| Sector | Public |
| Country | United States |
| Start | 10/2017 |
| End | 10/2019 |
| Description | Religious belief, health, and disease: a family perspective II. The follow-up and analyses |
| Amount | £8,000,000 (GBP) |
| Funding ID | 61917 |
| Organisation | The John Templeton Foundation |
| Sector | Academic/University |
| Country | United States |
| Start | 09/2021 |
| End | 08/2026 |
| Description | Siddhartha Kar UKRI Future Leader Fellowship |
| Amount | £818,050 (GBP) |
| Funding ID | MR/T043202/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2020 |
| End | 09/2024 |
| Description | Study of emerging adulthood and cardiometabolic health in ALSPAC: the influence of growth and other exposures (SEA CHANGE) |
| Amount | £999,049 (GBP) |
| Funding ID | CS/15/6/31468 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2015 |
| End | 07/2020 |
| Description | WCRF Investigator Initiated Grant |
| Amount | £264,000 (GBP) |
| Organisation | World Cancer Research Fund |
| Sector | Charity/Non Profit |
| Country | Global |
| Start | 01/2021 |
| End | 12/2023 |
| Title | A web application for exploring tissue specific consequences of genetic variation |
| Description | This web application can be used to investigate associations between genome-wide gene expression and 395 complex traits by applying Mendelian randomization and genetic colocalization1. Analyses have been undertaken using gene expression derived from whole blood made available by the eQTLGen consortium2 (n=31,684), as well as 48 different tissue types from the GTEx project3. Findings from this web application can help uncover associations yet to be detected by genome-wide association studies and also investigate tissue-specific effects between gene expression and complex traits. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | The app has seen widespread use by the research community including non-academic partners. |
| URL | http://mrcieu.mrsoftware.org/molecular_MR_atlas |
| Title | Analysis package for identifying differentially methylation regions |
| Description | Statistical power in epigenome-wide association studies (EWAS) tends to be low due to the cost of generating genome-wide DNA methylation profiles. dmrff increases the power of EWAS by testing associations with DNA methylation measurements spread across regions rather than being limited to individual genomic loci. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | Widespread adoption as an analytical tool by the research community. |
| URL | https://github.com/perishky/dmrff |
| Title | GARFIELD - J.Min |
| Description | Josine Min has developed a novel approach that leverages genome-wide association studies' findings with regulatory or functional annotations to classify features relevant to a phenotype of interest. GARFIELD classifies disease-relevant genomic features through integration of functional annotations with association signals |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | This tool has been cited in at least 21 publications. |
| URL | https://www.ebi.ac.uk/birney-srv/GARFIELD/ |
| Title | Meffil - J.Min |
| Description | Josine Min and other researchers have developed a new tool for performing quality control and preprocessing large sets of DNA methylation profiles used in epidemiological studies. Previous tools were unable to process such large datasets without requiring high-end computational resources. Our tool may also be used to improve statistical power in meta-analyses. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | This package has been used to analyse 36 datasets from the GoDMC consortium. It has been cited by 20 publications. |
| URL | https://github.com/perishky/meffil#meffil |
| Title | EWAS Catalog |
| Description | A database of epigenome-wide association studies with seacrh tool |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | None as yet |
| URL | http://www.ewascatalog.org |
| Title | EWAS Catalog |
| Description | A database providing summary statistics from both published and unpublished epigenome-wide association studies. The database can be queried online or programmatically using an R package. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | None yet |
| URL | http://ewascatalog.org/ |
| Title | EWAS Catalog |
| Description | A database providing summary statistics from both published and unpublished epigenome-wide association studies. The database can be queried online or programmatically using an R package. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | None yet |
| URL | http://ewascatalog.org/ |
| Title | Genetics of DNA methylation Consortium (GoDMC) - Josine Min |
| Description | As part of the GoDMC (Genetics of DNA methylation Consortium) we have generated a database which contains all discovered mQTL associations. It also has a dalliance genome browser to explore regional features of the association. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | We have developed a github pipeline for the GoDMC consortium. So far, 36 different groups have processed and analysed their data and uploaded the results to our sftp server.We have since made the database publicly available following the upload of the main study manuscript to a pre-print server. The resource has seen widespread use by the research community. http://mqtldb.godmc.org.uk |
| Title | Identification of differentially methylated regions |
| Description | This software tool improves on previous work by properly controlling false positive rates, providing support for meta-analysis and increasing statistical power |
| Type Of Material | Data analysis technique |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | None as yet |
| Title | Paternal BMI meta-EWAS results |
| Description | This project explores associations between paternal body mass index around the time of conception and offspring DNA methylation in cord blood at birth and peripheral whole blood at childhood. Independent cohorts carried out epigenome-wise association studies (EWAS) according to a pre-specified analysis plan. The summary statistics from these EWAS were then meta-analysed. This dataset provides the full summary statistics for the project. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | A paper describing this study has been published and the data has been uploaded to the EWAS catalog for further use and dissemination by other groups. |
| URL | https://dataverse.harvard.edu/dataverse/pace_paternal_bmi_methylation |
| Description | 4M consortium |
| Organisation | Cardiff University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Gemma Sharp established the Menarche, Menstruation, Menopause and Mental health (4M) consortium using funding from the GW4 Alliance (generator award: £14800). The consortium brings together researchers from different disciplines and institutions, with a shared interest in the intersection of menstrual and mental health. This includes researchers interested in using molecular epidemiological approaches to conduct research in this area. |
| Collaborator Contribution | The 4M consortium includes partners from Bath, Cardiff and Exeter University, as well as external stakeholders from charities, patient groups, the NHS, government departments, and the United Nations Population Fund (UNFPA). |
| Impact | We have run several workshops, including a three day in-person grant writing retreat. We have developed and submitted four grant applications for further funding. |
| Start Year | 2021 |
| Description | 4M consortium |
| Organisation | GW4 |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Gemma Sharp established the Menarche, Menstruation, Menopause and Mental health (4M) consortium using funding from the GW4 Alliance (generator award: £14800). The consortium brings together researchers from different disciplines and institutions, with a shared interest in the intersection of menstrual and mental health. This includes researchers interested in using molecular epidemiological approaches to conduct research in this area. |
| Collaborator Contribution | The 4M consortium includes partners from Bath, Cardiff and Exeter University, as well as external stakeholders from charities, patient groups, the NHS, government departments, and the United Nations Population Fund (UNFPA). |
| Impact | We have run several workshops, including a three day in-person grant writing retreat. We have developed and submitted four grant applications for further funding. |
| Start Year | 2021 |
| Description | 4M consortium |
| Organisation | University of Bath |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Gemma Sharp established the Menarche, Menstruation, Menopause and Mental health (4M) consortium using funding from the GW4 Alliance (generator award: £14800). The consortium brings together researchers from different disciplines and institutions, with a shared interest in the intersection of menstrual and mental health. This includes researchers interested in using molecular epidemiological approaches to conduct research in this area. |
| Collaborator Contribution | The 4M consortium includes partners from Bath, Cardiff and Exeter University, as well as external stakeholders from charities, patient groups, the NHS, government departments, and the United Nations Population Fund (UNFPA). |
| Impact | We have run several workshops, including a three day in-person grant writing retreat. We have developed and submitted four grant applications for further funding. |
| Start Year | 2021 |
| Description | 4M consortium |
| Organisation | University of Exeter |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Gemma Sharp established the Menarche, Menstruation, Menopause and Mental health (4M) consortium using funding from the GW4 Alliance (generator award: £14800). The consortium brings together researchers from different disciplines and institutions, with a shared interest in the intersection of menstrual and mental health. This includes researchers interested in using molecular epidemiological approaches to conduct research in this area. |
| Collaborator Contribution | The 4M consortium includes partners from Bath, Cardiff and Exeter University, as well as external stakeholders from charities, patient groups, the NHS, government departments, and the United Nations Population Fund (UNFPA). |
| Impact | We have run several workshops, including a three day in-person grant writing retreat. We have developed and submitted four grant applications for further funding. |
| Start Year | 2021 |
| Description | ALPHABET |
| Organisation | University College Dublin |
| Department | School of Public Health, Physiotherapy and Population Science |
| Country | Ireland |
| Sector | Academic/University |
| PI Contribution | I am a co-investigator on a ERA-HDHL (BBSRC) collaborative research project on the influence of early life nutrition on offspring health led by UCD. Our contribution includes collating multi-centre epigenetic data, running epigenome-wide association studies, meta-analyses and causal analysis methods. |
| Collaborator Contribution | The partners in this collaboration contribute data from various large birth cohort studies and expertise in nutrition and other clinical disciplines |
| Impact | Aubert A, Forhan A, de Lauzon-Guillain B, Chen LW, Polanska K, Hanke W, Mensink-Bout SM, Duijts L, Suderman M, Relton CL, Crozier SR, Harvey NC, Cooper C, McAuliffe FM, Kelleher CC, Philips CM, Heude B, Bernard JY. Deriving the Dietary Approaches to stop Hypertension (DASH) score in women from seven pregnancy cohorts from the European ALPHABET consortium. Nutrients. 2019 Nov 8;11(11). pii: E2706. doi: 10.3390/nu11112706. PMID:31717283. Chen LW, Aubert AM, Shivappa N, Bernard JY, Mensink-Bout SM, Geraghty AA, Mehegan J, Suderman M, Polanska K, Hanke W, Trafalska E, Relton CL, Crozier SR, Harvey NC, Cooper C, Duijts L, Heude B, Hébert JR, McAuliffe FM, Kelleher CC, Phillips CM. Associations of maternal dietary inflammatory potential and quality with offspring birth outcomes: An individual participant data pooled analysis of 7 European cohorts in the ALPHABET consortium. PLoS Med. 2021 Jan 21;18(1):e1003491. doi: 10.1371/journal.pmed.1003491. eCollection 2021 Jan. PMID: 33476335. Chen LW, Aubert AM, Shivappa N, Bernard JY, Mensink-Bout SM, Geraghty AA, Mehegan J, Suderman M, Polanska K, Hanke W, Jankowska A, Relton CL, Crozier SR, Harvey NC, Cooper C, Hanson M, Godfrey KM, Gaillard R, Duijts L, Heude B, Hébert JR, McAuliffe FM, Kelleher CC, Phillips CM. Maternal dietary quality, inflammatory potential and childhood adiposity: an individual participant data pooled analysis of seven European cohorts in the alphabet consortium. BMC Med. 2021 Feb 22;19(1):33. doi: 10.1186/s12916-021-01908-7. PMID: 33612114. |
| Start Year | 2017 |
| Description | Alcohol Exposure |
| Organisation | University of Toronto |
| Department | Baycrest Centre for Geriatric Care |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | Joint analysis of ALSPAC (epigenetic) data and imaging phenotypes obtained by Toronto group |
| Collaborator Contribution | Imaging phenotypes obtained by Toronto group |
| Impact | PhD thesis completed on the relationship between prenatal alcohol exposure, own alcohol use and neuroimaging phenotypes. |
| Start Year | 2016 |
| Description | BIOMAP- Biomarkers in Atopic Dermatitis and Psoriasis |
| Organisation | London School of Hygiene and Tropical Medicine (LSHTM) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Josine Min is a task PI of WP3. She developed templates for data access for third party datasets and as custodian for a number of datasets has submitted data applications for the consortium. We finalised the extended collection of an eczema ALSPAC sub-study (PAXGENE tube, PBMC tube and skin biopsy). We contributed to the development of the BIOMAP glossary, contributed to the pre-processing and analysis pipeline of BIOMAP WP2 by contributing software (R packages meffil, EWAFF, DMRFF). We generated analysis plans to conduct an EWAS and a TWAS across a large number of datasets for AD and Psoriasis endotypes. |
| Collaborator Contribution | The European research project BIOMAP (Biomarkers in Atopic Dermatitis and Psoriasis) is the first large-scale multinational public-private partnership on chronic inflammatory skin diseases. This five-year project will address key unmet needs in understanding atopic dermatitis and psoriasis by analysing data from more than 50,000 patients, and have a broad impact on improving disease understanding, patient care and development of future therapies (www.biomap-imi.eu). The team comprises 26 academic and five industry partners as well as five patient organisations from 12 countries. The partner organisation make a wide range of contributions to consortium activities. |
| Impact | The team comprises 26 academic and five industry partners as well as five patient organisations from 12 countries. The team has dermatologists, bioinformaticians, epidemiologists etc. |
| Start Year | 2019 |
| Description | BIOMAP- Biomarkers in Atopic Dermatitis and Psoriasis |
| Organisation | University of Kiel |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Josine Min is a task PI of WP3. She developed templates for data access for third party datasets and as custodian for a number of datasets has submitted data applications for the consortium. We finalised the extended collection of an eczema ALSPAC sub-study (PAXGENE tube, PBMC tube and skin biopsy). We contributed to the development of the BIOMAP glossary, contributed to the pre-processing and analysis pipeline of BIOMAP WP2 by contributing software (R packages meffil, EWAFF, DMRFF). We generated analysis plans to conduct an EWAS and a TWAS across a large number of datasets for AD and Psoriasis endotypes. |
| Collaborator Contribution | The European research project BIOMAP (Biomarkers in Atopic Dermatitis and Psoriasis) is the first large-scale multinational public-private partnership on chronic inflammatory skin diseases. This five-year project will address key unmet needs in understanding atopic dermatitis and psoriasis by analysing data from more than 50,000 patients, and have a broad impact on improving disease understanding, patient care and development of future therapies (www.biomap-imi.eu). The team comprises 26 academic and five industry partners as well as five patient organisations from 12 countries. The partner organisation make a wide range of contributions to consortium activities. |
| Impact | The team comprises 26 academic and five industry partners as well as five patient organisations from 12 countries. The team has dermatologists, bioinformaticians, epidemiologists etc. |
| Start Year | 2019 |
| Description | Bristol City Council |
| Organisation | Bristol City Council |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | C Rlton: PI of the study and provides advice to BCC on COVID-related research. |
| Collaborator Contribution | Partnership in the design and delivery of a COVID-19 study of Bristol schools. |
| Impact | Newsletters, media coverage and other outputs are detailed on the study website. |
| Start Year | 2020 |
| Description | Brown & Shahab - Targeting multiple levels of the smoking cessation system using novel scientific approaches. |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Contributing towards the epigenetic assessment of novel nicotine product users. Support for the programme including time to attend strategic management meetings, advise on research questions, contribute to PhD student placements and enable pathways to impact. |
| Collaborator Contribution | CRUK Programme Grant Renewal |
| Impact | N/A |
| Start Year | 2021 |
| Description | Copenhagen University |
| Organisation | Copenhagen University Hospital |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | We bring epigenetic epidemiology expertise. This collaboration is focused around the exploration of DNA methylation as an intermediate linking cigarette smoke exposure to a wide range of health outcomes. |
| Collaborator Contribution | The collaborators bring access to and biosamples from their very large population based resources, namely the Copenhagen City Heart Study |
| Impact | Manuscripts under submission and further papers are in preparation. |
| Start Year | 2013 |
| Description | Dalgaard - Epigenetic factors in cardiometabolic disease: a study of discordant MZ twins |
| Organisation | University of Southern Denmark |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Intellectual contributions, generation of DNA methylation data |
| Collaborator Contribution | GEMINAKAR study: Intellectual contributions, sample provision, genetic data provision |
| Impact | No outputs yet |
| Start Year | 2021 |
| Description | EPIC DIVE - Early PancreatIc Cancer Diagnosis In Vivo Evaluation |
| Organisation | NHS England |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Aim is investigate methods for amplifying circulating tumour DNA in vivo that could be used for early cancer detection. |
| Collaborator Contribution | Machine learning and mathematical modelling |
| Impact | EPIC DIVE - Early Pancreatic Cancer Diagnosis In Vivo Evaluation Research Grant (as above CRUK funded £228,000) |
| Start Year | 2022 |
| Description | EPIC DIVE - Early PancreatIc Cancer Diagnosis In Vivo Evaluation |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Aim is investigate methods for amplifying circulating tumour DNA in vivo that could be used for early cancer detection. |
| Collaborator Contribution | Machine learning and mathematical modelling |
| Impact | EPIC DIVE - Early Pancreatic Cancer Diagnosis In Vivo Evaluation Research Grant (as above CRUK funded £228,000) |
| Start Year | 2022 |
| Description | EPIC DIVE - Early PancreatIc Cancer Diagnosis In Vivo Evaluation |
| Organisation | University of Surrey |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Aim is investigate methods for amplifying circulating tumour DNA in vivo that could be used for early cancer detection. |
| Collaborator Contribution | Machine learning and mathematical modelling |
| Impact | EPIC DIVE - Early Pancreatic Cancer Diagnosis In Vivo Evaluation Research Grant (as above CRUK funded £228,000) |
| Start Year | 2022 |
| Description | EPIC DIVE - Early PancreatIc Cancer Diagnosis In Vivo Evaluation |
| Organisation | University of the West of England |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Aim is investigate methods for amplifying circulating tumour DNA in vivo that could be used for early cancer detection. |
| Collaborator Contribution | Machine learning and mathematical modelling |
| Impact | EPIC DIVE - Early Pancreatic Cancer Diagnosis In Vivo Evaluation Research Grant (as above CRUK funded £228,000) |
| Start Year | 2022 |
| Description | EPSRC - Living fast and showing off? Evaluating individual and social influences on risky behaviour |
| Organisation | University of Exeter |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Project idea and design, feedback on application, supervision |
| Collaborator Contribution | Project idea and design (TF), application writing (SH), supervision (CW, CB, MK-R) |
| Impact | EPSRC PhD funding awarded to Steph Hunt Multidisciplinary: Psychology, epidemiology, biology, data science |
| Start Year | 2019 |
| Description | ESRC Biomarker Data Project Fellowship in Understanding Society - R Richmond |
| Organisation | University of Essex |
| Department | Institute for Social and Economic Research, Essex |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data analysis of Understanding Society data. |
| Collaborator Contribution | Data provision for Understanding Society and mentorship. |
| Impact | Rebecca Richmond was awarded an ESRC fellowship. |
| Start Year | 2018 |
| Description | EpiPREG |
| Organisation | Oslo University Hospital |
| Country | Norway |
| Sector | Hospitals |
| PI Contribution | Intellectual contributions, generation of DNA methylation data |
| Collaborator Contribution | Intellectual contributions, sample provision, genetic data provision |
| Impact | No outputs yet |
| Start Year | 2021 |
| Description | Epigenetic ageing and biomarkers |
| Organisation | University of California, Los Angeles (UCLA) |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Collaboration on research related to epigenetic ageing and biomarkers that provide a measure of this. We have led on Mendelian randomization analyses within this consortium. |
| Collaborator Contribution | Expertise in epigenetic age measures |
| Impact | Langdon R, Beynon RA, Ingarfield K, Marioni RE, MacCartney DM, Martin RM, Ness AR, Pawlita M, Waterboer T, Relton C, Thomas SJ, Richmond RC. Epigenetic prediction of complex traits and mortality in a cohort of individuals with oropharyngeal cancer. Clinical Epigenetics, 2020; 12: 1-14 McCartney DL*, Min JL*, Richmond RC*, Lu AT*, Sobzyk MK*, Davies G* et al. Genome-wide association studies identify 137 loci for DNA methylation biomarkers of aging. bioRxiv https://doi.org/10.1101/2020.06.29.133702 Beynon R, Ingle S, Landon R, May M, Ness A, Martin R, Suderman M, Ingarfield K, Marioni R, McCartney D, Waterboer T, Pawlita M, Relton C, Davey Smith G, Richmond RC. Epigenetic biomarkers of ageing are predictive of mortality risk in a longitudinal clinical cohort of individuals diagnosed with oropharyngeal cancer. medRxiv https://doi.org/10.1101/2020.02.04.20020198. |
| Start Year | 2019 |
| Description | Epigenetic ageing and biomarkers |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration on research related to epigenetic ageing and biomarkers that provide a measure of this. We have led on Mendelian randomization analyses within this consortium. |
| Collaborator Contribution | Expertise in epigenetic age measures |
| Impact | Langdon R, Beynon RA, Ingarfield K, Marioni RE, MacCartney DM, Martin RM, Ness AR, Pawlita M, Waterboer T, Relton C, Thomas SJ, Richmond RC. Epigenetic prediction of complex traits and mortality in a cohort of individuals with oropharyngeal cancer. Clinical Epigenetics, 2020; 12: 1-14 McCartney DL*, Min JL*, Richmond RC*, Lu AT*, Sobzyk MK*, Davies G* et al. Genome-wide association studies identify 137 loci for DNA methylation biomarkers of aging. bioRxiv https://doi.org/10.1101/2020.06.29.133702 Beynon R, Ingle S, Landon R, May M, Ness A, Martin R, Suderman M, Ingarfield K, Marioni R, McCartney D, Waterboer T, Pawlita M, Relton C, Davey Smith G, Richmond RC. Epigenetic biomarkers of ageing are predictive of mortality risk in a longitudinal clinical cohort of individuals diagnosed with oropharyngeal cancer. medRxiv https://doi.org/10.1101/2020.02.04.20020198. |
| Start Year | 2019 |
| Description | European Bioinformatics Institute |
| Organisation | EMBL European Bioinformatics Institute (EMBL - EBI) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We bring epidemiological and causal analysis expertise to this collaboration as well as generating epigenomic data for use by colleagues at EBI. |
| Collaborator Contribution | Bioinformatic expertise for the functional annotation of observed associations. |
| Impact | EBI have been involved in ARIES and have more recently been closely involved in formulating large strategic funding applications. The outputs of this work are too early to report. This is a multi-disciplinary collaboration between epidemiologists and bioinformaticians. |
| Start Year | 2013 |
| Description | GW4 |
| Organisation | Cardiff University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The GW4 strategic alliance has established the GW4 Epigenetics Consortium which I instigated and brings complementary expertise from the 4 contributing Universitites together.We hosted a 2 day symposium and workshops and have subsequently secured and undertaken research activities around the use of CRISPR/Cas9 in epigenetics studies |
| Collaborator Contribution | 2 day symposium and workshops. Epidemiology expertise. |
| Impact | 2 day symposium and workshops. Further grant application to GW4 for research activities. This is a multi-disciplinary collaboration between epidemiologists, clinicians, experimental biologists, bioinformaticians and epigeneticists |
| Start Year | 2014 |
| Description | GW4 |
| Organisation | University of Bath |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The GW4 strategic alliance has established the GW4 Epigenetics Consortium which I instigated and brings complementary expertise from the 4 contributing Universitites together.We hosted a 2 day symposium and workshops and have subsequently secured and undertaken research activities around the use of CRISPR/Cas9 in epigenetics studies |
| Collaborator Contribution | 2 day symposium and workshops. Epidemiology expertise. |
| Impact | 2 day symposium and workshops. Further grant application to GW4 for research activities. This is a multi-disciplinary collaboration between epidemiologists, clinicians, experimental biologists, bioinformaticians and epigeneticists |
| Start Year | 2014 |
| Description | GW4 |
| Organisation | University of Exeter |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The GW4 strategic alliance has established the GW4 Epigenetics Consortium which I instigated and brings complementary expertise from the 4 contributing Universitites together.We hosted a 2 day symposium and workshops and have subsequently secured and undertaken research activities around the use of CRISPR/Cas9 in epigenetics studies |
| Collaborator Contribution | 2 day symposium and workshops. Epidemiology expertise. |
| Impact | 2 day symposium and workshops. Further grant application to GW4 for research activities. This is a multi-disciplinary collaboration between epidemiologists, clinicians, experimental biologists, bioinformaticians and epigeneticists |
| Start Year | 2014 |
| Description | GW4 - Brain age as a marker of mental and physical well-being |
| Organisation | University of Exeter |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Project idea and design, feedback on application, supervision |
| Collaborator Contribution | Project idea and design, application, supervision |
| Impact | GW4-BioMed DTP PhD funding awarded to Constantinos Constantinides Multidisciplinary: Psychology, epidemiology, psychiatry |
| Start Year | 2019 |
| Description | GoDMC: Genetics of DNA Methylation Consortium |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We are currently leading the GoDMC consortium. The GoDMC consortium consists of five core groups (IEU, Kings College London, University of Exeter, Leiden University Medical Centre and Austrian Academy of Sciences) and we recruited 30+ cohorts to contribute to the GoDMC consortium. We have led the analysis effort for this consortium, led the writing of the main manuscript and are co-ordinating the ongoing consortium activities. Matt Suderman and Josine Min have developed an R package "Efficient algorithms for analyzing DNA methylation data" (meffil) (https://github.com/perishky/meffil) which is designed to conduct quality control and normalization of large-scale methylation datasets. Meffil also conducts epigenome wide association studies (EWAS) using four different methods. In addition, Josine Min and Gibran Hemani have written a pipeline on github, which automates all analyses. Participating cohorts will download the pipeline and will follow instructions to run the pipeline. |
| Collaborator Contribution | Partners have ade substantive contributions to the analysis effort, to data provision and to interpretation of data generated. |
| Impact | Software development: R package meffil and github pipeline for GoDMC analyses Disciplines: Genetic epidemiology, epigenetic epidemiology Main manuscript, published in Nature Genetics. PMID: 34493871 Summary genetic association data have been deposited and are available for open access. Follow up studies planned and underway. |
| Start Year | 2013 |
| Description | GoDMC: Genetics of DNA Methylation Consortium |
| Organisation | Leiden University Medical Center |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We are currently leading the GoDMC consortium. The GoDMC consortium consists of five core groups (IEU, Kings College London, University of Exeter, Leiden University Medical Centre and Austrian Academy of Sciences) and we recruited 30+ cohorts to contribute to the GoDMC consortium. We have led the analysis effort for this consortium, led the writing of the main manuscript and are co-ordinating the ongoing consortium activities. Matt Suderman and Josine Min have developed an R package "Efficient algorithms for analyzing DNA methylation data" (meffil) (https://github.com/perishky/meffil) which is designed to conduct quality control and normalization of large-scale methylation datasets. Meffil also conducts epigenome wide association studies (EWAS) using four different methods. In addition, Josine Min and Gibran Hemani have written a pipeline on github, which automates all analyses. Participating cohorts will download the pipeline and will follow instructions to run the pipeline. |
| Collaborator Contribution | Partners have ade substantive contributions to the analysis effort, to data provision and to interpretation of data generated. |
| Impact | Software development: R package meffil and github pipeline for GoDMC analyses Disciplines: Genetic epidemiology, epigenetic epidemiology Main manuscript, published in Nature Genetics. PMID: 34493871 Summary genetic association data have been deposited and are available for open access. Follow up studies planned and underway. |
| Start Year | 2013 |
| Description | Goulder (Oxford University) |
| Organisation | University of Oxford |
| Department | Oxford University Innovation |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Dr Matt Suderman; Partner- Clinical knowledge, expert on immune responses in children, laboratory tools and skills, South African cohort, Aim is to investigate mechanisms causing sex-discordance in immune responses in early life using samples and data collected longitudinally from birth to adulthood. |
| Collaborator Contribution | Knowledge and experience with omic data, especially DNA methylation, ALSPAC cohort data, preprint on sex differences in DNA methylation (https://doi.org/10.1101/118265) |
| Impact | Grant application to Wellcome Trust submitted Feb 16, 2021 (Suderman is co-investigator) |
| Start Year | 2020 |
| Description | Hemmings (Stellenbosch) |
| Organisation | University of Stellenbosch |
| Country | South Africa |
| Sector | Academic/University |
| PI Contribution | Dr Matt Suderman; Partner- Expert in fetal alcohol syndrome and trauma, human cohort with high alcohol exposure To identify biomarkers of high alcohol intake and fetal alcohol syndrome in peripheral tissues collected from pregnant mothers. |
| Collaborator Contribution | Knowledge and tools for analyzing DNA methylation profiles and using them to create and validate predictors. |
| Impact | Two unsuccessful grant applications (MRC and Wellcome Trust) and one publication (PMID 34799556). |
| Start Year | 2018 |
| Description | IARC |
| Organisation | International Agency for Research on Cancer (IARC) |
| Country | France |
| Sector | Academic/University |
| PI Contribution | This long-standing collaboration (consolidated by a short sabbatical in 2008) led to a large scale NIH funded biomarker study which is ongoing. More recently, a CRUK programme in integrative cancer epidemiology has been awarded on which I am Co-PI. I bring programme leadership and epigenetic epidemiology and causal analysis expertise. |
| Collaborator Contribution | Genetic epidemiology and access to large multi-national consortia. |
| Impact | P Brennan, M Johansson, CL Relton, PM Ueland, P Vineis et al. One carbon metabolism biomarkers and lung cancer risk. Sep 2011-Aug 2016 NIH/NCI R01 [$5,060,000] Co-I Martin RM (Co-PI), Relton CL (Co-PI) et al. Reducing the burden of cancer: Causal risk factors, mechanistic targets and predictive biomarkers. £4.15M. CRUK Programme. Jun 2015 - May 2020. Johansson M, Fanidi A, Muller D, Bassett J, Midttun Ø, Vollset SE, Travis R, Palli D, Mattiello A, Sieri S, Trichopoulou A, Lagiou P, Trichopoulos D, Ljungberg B, Hallmans G, Weiderpass E, Skeie G, González C, Dorronsoro M, Peeters P, Bueno-de-Mesquita HB, Ros M, Boutron-Ruault MC, Fagherazzi G, Clavel-Chapelon F, Sánchez MJ, Barricarte Gurea A, Navarro C, Quirós JR, Overvad K, Tjønneland A, Aleksandrova K, Vineis P, Gunter M, Giles G, Relton C, Riboli E, Boeing H, Ueland PM, Severi G, Brennan P. Circulating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survival. J Natl Cancer Inst 2014;106(12):pii. PMID: 25376861 Fanidi A, Relton CL, Ueland PM, Midtun Ø, Vollset SE, Travis RC, Trichopoulou A, Lagiou P, Trichopoulos D, Bueno-de-Mesquita HB, Ros M, Boeing H, Tumino R, Panico S, Palli D, Sieri S, Vineis P, Sánchez MJ, Huerta JM, Barricarte Gurrea A, Luján-Barroso L, Quirós JR, Tjønneland A, Halkjær J, Boutron-Ruault MC, Clavel-Chapelon F, Cadeau C, Weiderpass E, Johansson M, Riboli E, Brennan P, Johansson M. A prospective study of one-carbon metabolism biomarkers and cancer of the head, neck and oesophagus. Int J Cancer 2014;136(4):915-27. PMID: 24975698 Fasanelli F, Baglietto L, Ponzi E, Guida F, Campanella G, Johansson M, Grankvist K, Johansson M, Assumma MB, Naccarati A, Chadeau-Hyam M, Ala U, Faltus C, Kaaks R, Risch A, De Stavola B, Hodge A, Giles GG, Southey MC, Relton CL, Haycock PC, Lund E, Polidoro S, Sandanger TM, Severi G, Vineis P. Hypomethylation of smoking-related gene is associated with future lung cancer in four prospective cohorts. Nat Commun 2015 Dec 15;6:10192. doi: 10.1038/ncomms10192. PMID: 26667048 Multiple additional manuscripts. Renewal of CRUK-funded programme grant from 2020-2025, with a larger body of research planned. |
| Start Year | 2007 |
| Description | Jones (University of Bristol) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Dr Matt Suderman; Partner-Bat cohort data and samples, expert knowledge of bats. Aim is to better understand aging by investigating DNA methylation in bat species with extremely long lifespans. |
| Collaborator Contribution | Experience and tools for analysing genome-wide DNA methylation profiles and using to it evaluate biological aging and determinants. |
| Impact | None yet (one unsuccessful grant to BBSRC and one new submission to NERC with Suderman as co-investigator) |
| Start Year | 2020 |
| Description | Krieger - Harvard School of Public Health |
| Organisation | Harvard University |
| Department | Harvard T.H. Chan School of Public Health |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Epigenetic epidemiology expertise |
| Collaborator Contribution | Social epidemiology and social determinants of health. This collaboration, primarily with Prof Nancy Krieger, involves collaboration on biosocial epigenetics research. Prof Krieger leads a unique study on racial and economic discrimination on which we are conducting epigenetic studies. NIH R01 funded in 2020 to run for 3 years 7 months. Relton & Krieger MPIs. |
| Impact | Collaborators are involved in Relton CL (PI), Davey Smith G, Power C, Deary I, Davies N, Tilling K, Gaunt T, Munafo M, Windmeijer F, Visscher P, Marioni R, Ingram N, van den Berg G, Murtagh M. Epigenetics: Environment, Embodiment and Equality (E4). ESRC. £667,460. Krieger N (MPI), Relton CL (MPI), Waterman PD, Chen JT, Coull BA, De Vivo I, Diez-Roux A, Davey Smith G, Simpkin AJ, Tilling K, Suderman MJ, Freeman E. DNA methylation & adversity: pathways from exposures to health inequities. NIH (1R01MD014304). Sep 2019 - Aug 2023. $2,352,682/£1,742,728. |
| Start Year | 2014 |
| Description | Lightman & Upton (University of Bristol) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Aim is to investigate circadian rhythm in DNA methylation in serially collected blood samples across a circadian rhythm disruption. |
| Collaborator Contribution | Funds for sample storage and DNA methylation profiles, DNA methylation data generation, data analysis |
| Impact | No outcomes yet |
| Start Year | 2022 |
| Description | Longitudinal Epigenetics GenR - E Walton |
| Organisation | Erasmus MC |
| Country | Netherlands |
| Sector | Hospitals |
| PI Contribution | joint analysis of ALSPAC and GenR epigenetic data |
| Collaborator Contribution | joint analysis of ALSPAC and GenR epigenetic data |
| Impact | Walton E, Relton CL, Caramaschi D. Using openly accessible resources to strengthen causal inference in epigenetic epidemiology of neurodevelopment and mental health. Genes 2019 Mar 1;10(3). pii: E193. doi: 10.3390/genes10030193. PMID:308903164. Caramaschi D, Hatcher C, Mulder R, Felix JF, Cecil CAM, Relton CL, Walton E. Epigenome-wide association study of seizures in childhood and adolescence. Clin Epigen. 2020 Jan 8;12(1):8. doi: 10.1186/s13138-019-0793-z. PMID:31915053. Mulder RH, Walton E, Neumann A, Houtepen LC, Felix JF, Bakermans-Kranenburg MJ, Suderman M, Tiemeier H, van IJzendoorn MH, Relton CL, Cecil CAM. Epigenomics of being bullied: changes in DNA methylation following bullying exposure. Epigenetics. 2020 Jan 28:1-15. Doi: 10.1080/15592294.2020.1719303. PMID:31992121. Sammallahti S, Cortes Hidalgo AP, Tuominen S, Malmberg A, Mulder RH, Brunst KJ, Alemany S, McBride NS, Yousefi P, Heiss JA, McRae N, Page CM, Jin J, Pesce G, Caramaschi D, Rifas-Shiman SL, Koen N, Adams CD, Magnus MC, Baïz N, Ratanatharathorn A, Czamara D, Håberg SE, Colicino E, Baccarelli AA, Cardenas A, DeMeo DL, Lawlor DA, Relton CL, Felix JF, van IJzendoorn MH, Bakermans-Kranenburg MJ, Kajantie E, Räikkönen K, Sunyer J, Sharp GC, Houtepen LC, Nohr EA, Sørensen TIA, Téllez-Rojo MM, Wright RO, Annesi-Maesano I, Wright J, Hivert MF, Wright RJ, Zar HJ, Stein DJ, London SJ, Cecil CAM, Tiemeier H, Lahti J. Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation. Mol Psychiatry. 2021 Jan 7. doi: 10.1038/s41380-020-00976-0. Online ahead of print. PMID: 33414500. van Dongen J, Hagenbeek FA, Suderman M, Roetman PJ, Sugden K, Chiocchetti AG, Ismail K, Mulder RH, Hafferty JD, Adams MJ, Walker RM, Morris SW, Lahti J, Küpers LK, Escaramis G, Alemany S, Jan Bonder M, Meijer M, Ip HF, Jansen R, Baselmans BML, Parmar P, Lowry E, Streit F, Sirignano L, Send TS, Frank J, Jylhävä J, Wang Y, Mishra PP, Colins OF, Corcoran DL, Poulton R, Mill J, Hannon E, Arseneault L, Korhonen T, Vuoksimaa E, Felix JF, Bakermans-Kranenburg MJ, Campbell A, Czamara D, Binder E, Corpeleijn E, Gonzalez JR, Grazuleviciene R, Gutzkow KB, Evandt J, Vafeiadi M, Klein M, van der Meer D, Ligthart L; BIOS Consortium, Kluft C, Davies GE, Hakulinen C, Keltikangas-Järvinen L, Franke B, Freitag CM, Konrad K, Hervas A, Fernández-Rivas A, Vetro A, Raitakari O, Lehtimäki T, Vermeiren R, Strandberg T, Räikkönen K, Snieder H, Witt SH, Deuschle M, Pedersen NL, Hägg S, Sunyer J, Franke L, Kaprio J, Ollikainen M, Moffitt TE, Tiemeier H, van IJzendoorn MH, Relton C, Vrijheid M, Sebert S, Jarvelin MR, Caspi A, Evans KL, McIntosh AM, Bartels M, Boomsma DI. DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan. Mol Psychiatry. 2021 Jan 8. doi: 10.1038/s41380-020-00987-x. Online ahead of print. PMID: 33420481. Mulder RH, Neumann A, Cecil CAM, Walton E, Houtepen LC, Simpkin AJ, Rijlaarsdam J, Heijmans BT, Gaunt TR, Felix JF, Jaddoe VWV, Bakermans-Kranenburg MJ, Tiemeier H, Relton CL, van IJzendoorn MH, Suderman M. Epigenome-wide change and variation in DNA methylation in childhood: Trajectories from birth to adolescence. Hum Mol Genet. Jan 15:ddaa280. doi: 10.1093/hmg/ddaa280. Online ahead of print. PMID: 33450751. Mulder RH (PhD candidate), Epigenetics as a mediator between the effect of peer victimization on emotional development. 4 month visit to University of Bristol Academy van der Gaag Grant. Apr-Jul 2018 (Sponsor C Relton) PhD Viva examination by C Relton: Rosa Mulder, DNA methylation and stress in child development; a population-based approach, Erasmus Medical Center, Rotterdam (PhD), January 2021 |
| Start Year | 2016 |
| Description | MRC The Gambia |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Unit, The Gambia |
| Country | Gambia |
| Sector | Public |
| PI Contribution | Collaboration in epigenetics research. Co-investigator on recently funded award to establish a W African Bioresource in nutritional genetics and epigenetics. |
| Collaborator Contribution | Myself and members of my team have committed to helping our colleagues at the MRC Gambia Unit establish a bioresource to support molecular epidemiology research in the future. This will involve researcher exchanges,workshops and training in Bristol and the provision of ongoing support and capacity building in The Gambia. |
| Impact | Capacity building achieved through sharing of good practice. |
| Start Year | 2018 |
| Description | Norwegian Institute of Public Health |
| Organisation | Norwegian Institute of Public Health |
| Country | Norway |
| Sector | Public |
| PI Contribution | We bring epigenetic epidemiology expertise to this collaboration. |
| Collaborator Contribution | Access to a very large birth cohort as well as epidemiological and clincial expertise. |
| Impact | Inclusion in the PACE consortium. Training and exchange visits. Preparation of joint grant applications. Joint research publications e.g. "25-hydroxyvitamin D in pregnancy and genome wide cord blood DNA methylation in two pregnancy cohorts (MoBa and ALSPAC) The Journal of Steroid Biochemistry and Molecular Biology Suderman M, Stene LC, Bohlin J, Page CM, Holvik K, Parr CL, Magnus MC, Håberg Siri E, Joubert BR, Wu MC, London SJ, Relton C, Nystad W |
| Start Year | 2013 |
| Description | NutriPROGRAM consortium collaboration |
| Organisation | Barcelona Institute for Global Health |
| Country | Spain |
| Sector | Multiple |
| PI Contribution | We co-designed and lead work package 4 in the Nutriprogram consortium project. We also lead or contribute to several other activities in other work packages. |
| Collaborator Contribution | Other partners lead other work packages and contribute data and results to the work package we lead (WP4). |
| Impact | A collaboration agreement (including DTA) has been signed by all contributing members. The collaboration is multi-disciplinary, involving epidemiologists, geneticists, nutritionists, biologists and clinicians. |
| Start Year | 2019 |
| Description | NutriPROGRAM consortium collaboration |
| Organisation | Erasmus MC |
| Country | Netherlands |
| Sector | Hospitals |
| PI Contribution | We co-designed and lead work package 4 in the Nutriprogram consortium project. We also lead or contribute to several other activities in other work packages. |
| Collaborator Contribution | Other partners lead other work packages and contribute data and results to the work package we lead (WP4). |
| Impact | A collaboration agreement (including DTA) has been signed by all contributing members. The collaboration is multi-disciplinary, involving epidemiologists, geneticists, nutritionists, biologists and clinicians. |
| Start Year | 2019 |
| Description | NutriPROGRAM consortium collaboration |
| Organisation | Ludwig Maximilian University of Munich (LMU Munich) |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | We co-designed and lead work package 4 in the Nutriprogram consortium project. We also lead or contribute to several other activities in other work packages. |
| Collaborator Contribution | Other partners lead other work packages and contribute data and results to the work package we lead (WP4). |
| Impact | A collaboration agreement (including DTA) has been signed by all contributing members. The collaboration is multi-disciplinary, involving epidemiologists, geneticists, nutritionists, biologists and clinicians. |
| Start Year | 2019 |
| Description | NutriPROGRAM consortium collaboration |
| Organisation | University of British Columbia |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | We co-designed and lead work package 4 in the Nutriprogram consortium project. We also lead or contribute to several other activities in other work packages. |
| Collaborator Contribution | Other partners lead other work packages and contribute data and results to the work package we lead (WP4). |
| Impact | A collaboration agreement (including DTA) has been signed by all contributing members. The collaboration is multi-disciplinary, involving epidemiologists, geneticists, nutritionists, biologists and clinicians. |
| Start Year | 2019 |
| Description | NutriPROGRAM consortium collaboration |
| Organisation | Wageningen University & Research |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We co-designed and lead work package 4 in the Nutriprogram consortium project. We also lead or contribute to several other activities in other work packages. |
| Collaborator Contribution | Other partners lead other work packages and contribute data and results to the work package we lead (WP4). |
| Impact | A collaboration agreement (including DTA) has been signed by all contributing members. The collaboration is multi-disciplinary, involving epidemiologists, geneticists, nutritionists, biologists and clinicians. |
| Start Year | 2019 |
| Description | PURE-South Africa |
| Organisation | North-West University |
| Country | South Africa |
| Sector | Academic/University |
| PI Contribution | Dr Hannah Elliott; This collaboration is concerned with capacity building in epigenetic epidemiology in S Africa. Focused on a joint project comparing epigenetic signatures in rural and urban dwelling individuals. Dr Elliott has co-supervised a PhD student based at North-West University. My research team had contributed through the provision of advice on study design, samples processing and data generation at the University of Bristol, training in data analysis, support in drafting outputs. |
| Collaborator Contribution | Intellectual contributions, sample provision, some funding for sample analysis. |
| Impact | Cronjé, HT, Nienaber-Rousseau, C, Min, JL, Green, FR, Elliott HR & Pieters, M, 2021, "Comparison of DNA methylation clocks in Black South African men", Epigenomics. (accepted) Cronjé, HT, Elliott, HR, Nienaber-Rousseau, C, Green, F, Schutte, A & Pieters, M 2020, 'Methylation vs protein inflammatory biomarkers and their associations with cardiovascular function', Frontiers in Immunology, vol. 11, 1577. https://doi.org/10.3389/fimmu.2020.01577 PMID: 32849535 Cronjé, HT, Elliott, HR, Nienaber-Rousseau, C & Pieters, M 2020, 'Leveraging the urban-rural divide for epigenetic research', Epigenomics. https://doi.org/10.2217/epi-2020-0049 PMID: 32657149 Cronjé, HT, Elliott, HR, Nienaber-Rousseau, C & Pieters, M 2020, 'Replication and expansion of epigenome-wide association literature in a black South African population', Clinical Epigenetics, vol. 12, 6 (2020). https://doi.org/10.1186/s13148-019-0805-z PMID: 31910897 |
| Start Year | 2018 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | Center for Environmental Research and Children's Health |
| Department | The CHAMACOS Study |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | Columbia Center for Children's Environmental Health |
| Country | United States |
| Sector | Private |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | European Association for Research on Learning and Instruction (EARLI) |
| Country | Belgium |
| Sector | Public |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | European Huntington's Disease Network (Euro-HD) |
| Country | Germany |
| Sector | Charity/Non Profit |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | Federal Ministry for the Environment, Nature Conservation and Nuclear Safety (BMU) |
| Department | International Climate Initiative (ICI) |
| Country | Germany |
| Sector | Public |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | Finnish Birth Cohort |
| Country | Finland |
| Sector | Academic/University |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | GECKO Drenthe Birth Cohort |
| Country | Netherlands |
| Sector | Hospitals |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | GenExp |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | GenR |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | Glyndwr University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | Government of Canada |
| Department | Aboriginal Affairs and Northern Development |
| Country | Canada |
| Sector | Public |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | ITS United Kingdom |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | Inmarsat |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | MTT Ltd Machine Tools Technologies |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | National Institute of Environmental Health Sciences |
| Department | Norway Facial Clefts Study (NCL) |
| Country | United States |
| Sector | Public |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | National Institute of Standards & Technology (NIST) |
| Country | United States |
| Sector | Public |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | National Institutes of Health (NIH) |
| Department | National Heart, Lung, and Blood Institute (NHLBI) |
| Country | United States |
| Sector | Public |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | New Hampshire Birth Cohort Study |
| Country | United States |
| Sector | Private |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | PRISMA ONG |
| Country | Peru |
| Sector | Private |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | Progressive Energy Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | Project Viva |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | Rhode Island Child Health Study |
| Sector | Charity/Non Profit |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | Rutherford Appleton Laboratory |
| Department | Space Science and Technology Department |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | University of Bristol |
| Department | Avon Longitudinal Study of Parents and Children (ALSPAC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | University of Cambridge |
| Department | PomBase |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | University of Western Australia |
| Department | Raine Medical Research Foundation |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Pregnancy and Childhood Epigenetics (PACE) |
| Organisation | VCE Mobile & Personal Comm Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB) |
| Collaborator Contribution | Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS). |
| Impact | Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation. |
| Start Year | 2014 |
| Description | Roswell Park |
| Organisation | University at Buffalo |
| Department | Roswell Park Cancer Institute |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Dr Rebecca Richmond; We shared a protocol for obtaining saliva samples from study participants which we will use to assess DNA methylation changes. We have also provided saliva kits for the samples to be collected. |
| Collaborator Contribution | Roswell Park has been collecting saliva samples from their study assessing e-cigarette use which we will later use to investigate DNA methylation changes. |
| Impact | None yet |
| Start Year | 2019 |
| Description | SABRE |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration in epigenetics research identifying ethnic differences in DNA methylation and associations between DNA methylation and cardiovascular disease and type 2 diabetes. |
| Collaborator Contribution | Provision of DNA samples and genetic data, intellectual input |
| Impact | 10.1038/s41588-021-00923-x 10.1371/journal.pone.0227728 10.1186/1868-7083-6-4 10.1093/ije/dyv010 |
| Start Year | 2013 |
| Description | Silver - LSHTM |
| Organisation | London School of Hygiene and Tropical Medicine (LSHTM) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Sharing of epigenetic epidemiology expertise Support for causal inference analyses. Replication studies. |
| Collaborator Contribution | Sharing of epigenetic epidemiology expertise. Replication studies. |
| Impact | Combined analysis in progress |
| Start Year | 2021 |
| Description | The HUNT study (Norwegian University of Science and Technology) |
| Organisation | Norwegian University of Science and Technology (NTNU) |
| Country | Norway |
| Sector | Academic/University |
| PI Contribution | Aim is to investigate ability of DNA methylation to capture variation in serum protein abundance variation. |
| Collaborator Contribution | Knowledge and experience with omic data, lab for DNA methylation generation |
| Impact | None yet |
| Start Year | 2020 |
| Description | Thirlwell (University of Exeter) |
| Organisation | University of Exeter |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Prof C Relton & Dr Matt Suderman; Epigenetic epidemiology expertise. Clinical knowledge, multi-omic tumor profile datasets and potential for further data capture. Aim is to better understand and predict outcomes of neuroendocrine tumors using multi-omic tumor profiles. |
| Collaborator Contribution | Machine learning tools and knowledge and experience with omic data. |
| Impact | Poster presentation at the 19th Annual ENETS Conference (Mar 10-11, 2022) |
| Start Year | 2020 |
| Description | UFPel |
| Organisation | Federal University of Pelotas (UFPel) |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | Epigenetic epidemiology expertise. Training provision (hosting of visiting researchers and delivery of training in Brazil) Contribution to co-supervision of a PhD student |
| Collaborator Contribution | Access to unique Brazilian birth cohorts. Maternal and perinatal epidemiology |
| Impact | Relton CL, Hartwig FP Davey Smith G. From stem cells to the law courts: DNA methylation, the forensic epigenome and the possibility of a biosocial archive. Int J Epidemiol 2015 44 (4): 1083-1093. doi: 10.1093/ije/dyv198 Genomics, Epigenomics and Causal Inference in Population Health, Federal University of Pelotas, Brazil, March 2015 |
| Start Year | 2013 |
| Description | UK Biobank Sleep Working Group |
| Organisation | Harvard University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Dr Rebecca Richmond; Ccontributed data analysis to consortium projects, writing and critical evaluation of manuscripts |
| Collaborator Contribution | Rebecca Richmond contributed data analysis to consortium projects, writing and critical evaluation of manuscripts |
| Impact | Lane JM, Jones S, Dashti H, Wood A, Aragam K, van Hees VT, Brumpton B, Wisvold BS, Wang H, Bowden J, Song T, Patel K, Anderson SG, Beaumont R, Bechtold DA, Cade B, Kathiresan S, Little MA, Luik AI, Loudon AS, Purcell S, Richmond RC, et al. Biological and clinical insights from genetics of insomnia symptoms. Nature Genetics, 2018 https://doi.org/10.1038/s41588-019-0361-7 Wang H, Lane JM, Jones SE, Dashti H, Ollila H, Wood AR, van Hees VT, Brumpton B, Winsvold BS, Kantojarvi K, Cade BE, Sofer T, Song Y, Patel K, Anderson SG, Bechtold DA, Bowden J, Emsley R, Kyle SD, Little MA, Loudon AS, Scheer AJL, Purcell SM, Richmond RC, et al. Genome-wide association analysis of excessive daytime sleepiness identified 42 loci that suggest phenotypic subgroups. Nature Communications 2019; 10.1038/s41467-019-11456-7 Richmond RC, Anderson EL, Dashti HS et al. Investigating causal relations between sleep traits and risk of breast cancer in women: a Mendelian randomization study. British Medical Journal, 2019 Liu J*, Richmond RC*, Bowden J, Barry C, Dashti HS, Daghlas I, Lane JM, Jones SE, Wood AR, Frayling TM, Wright AK, Carr MJ, Anderson SG, Emsley R, Ray D, Weedon MN, Saxena R, Lawlor DA, Rutter MK. Assessing the causal role of sleep traits on glycated haemoglobin: a Mendelian randomization study. medRxiv https://doi.org/10.1101/2020.12.18.20224733 Daghlas I, Richmond RC, Dashti HS, Ollila H, Lane J, Schernhammer ES, Davey Smith G, Rutter MK, Saxena R, Vetter C. Mendelian randomization reveals a causal gradient of lower educational attainment and greater body mass index on selection into shift work. IJE 2021 Anderson EL, Richmond RC, Jones SE et al. Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis. IJE 2020 |
| Start Year | 2017 |
| Description | UK Biobank Sleep Working Group |
| Organisation | University of Exeter |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Dr Rebecca Richmond; Ccontributed data analysis to consortium projects, writing and critical evaluation of manuscripts |
| Collaborator Contribution | Rebecca Richmond contributed data analysis to consortium projects, writing and critical evaluation of manuscripts |
| Impact | Lane JM, Jones S, Dashti H, Wood A, Aragam K, van Hees VT, Brumpton B, Wisvold BS, Wang H, Bowden J, Song T, Patel K, Anderson SG, Beaumont R, Bechtold DA, Cade B, Kathiresan S, Little MA, Luik AI, Loudon AS, Purcell S, Richmond RC, et al. Biological and clinical insights from genetics of insomnia symptoms. Nature Genetics, 2018 https://doi.org/10.1038/s41588-019-0361-7 Wang H, Lane JM, Jones SE, Dashti H, Ollila H, Wood AR, van Hees VT, Brumpton B, Winsvold BS, Kantojarvi K, Cade BE, Sofer T, Song Y, Patel K, Anderson SG, Bechtold DA, Bowden J, Emsley R, Kyle SD, Little MA, Loudon AS, Scheer AJL, Purcell SM, Richmond RC, et al. Genome-wide association analysis of excessive daytime sleepiness identified 42 loci that suggest phenotypic subgroups. Nature Communications 2019; 10.1038/s41467-019-11456-7 Richmond RC, Anderson EL, Dashti HS et al. Investigating causal relations between sleep traits and risk of breast cancer in women: a Mendelian randomization study. British Medical Journal, 2019 Liu J*, Richmond RC*, Bowden J, Barry C, Dashti HS, Daghlas I, Lane JM, Jones SE, Wood AR, Frayling TM, Wright AK, Carr MJ, Anderson SG, Emsley R, Ray D, Weedon MN, Saxena R, Lawlor DA, Rutter MK. Assessing the causal role of sleep traits on glycated haemoglobin: a Mendelian randomization study. medRxiv https://doi.org/10.1101/2020.12.18.20224733 Daghlas I, Richmond RC, Dashti HS, Ollila H, Lane J, Schernhammer ES, Davey Smith G, Rutter MK, Saxena R, Vetter C. Mendelian randomization reveals a causal gradient of lower educational attainment and greater body mass index on selection into shift work. IJE 2021 Anderson EL, Richmond RC, Jones SE et al. Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis. IJE 2020 |
| Start Year | 2017 |
| Description | UK Biobank Sleep Working Group |
| Organisation | University of Manchester |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Dr Rebecca Richmond; Ccontributed data analysis to consortium projects, writing and critical evaluation of manuscripts |
| Collaborator Contribution | Rebecca Richmond contributed data analysis to consortium projects, writing and critical evaluation of manuscripts |
| Impact | Lane JM, Jones S, Dashti H, Wood A, Aragam K, van Hees VT, Brumpton B, Wisvold BS, Wang H, Bowden J, Song T, Patel K, Anderson SG, Beaumont R, Bechtold DA, Cade B, Kathiresan S, Little MA, Luik AI, Loudon AS, Purcell S, Richmond RC, et al. Biological and clinical insights from genetics of insomnia symptoms. Nature Genetics, 2018 https://doi.org/10.1038/s41588-019-0361-7 Wang H, Lane JM, Jones SE, Dashti H, Ollila H, Wood AR, van Hees VT, Brumpton B, Winsvold BS, Kantojarvi K, Cade BE, Sofer T, Song Y, Patel K, Anderson SG, Bechtold DA, Bowden J, Emsley R, Kyle SD, Little MA, Loudon AS, Scheer AJL, Purcell SM, Richmond RC, et al. Genome-wide association analysis of excessive daytime sleepiness identified 42 loci that suggest phenotypic subgroups. Nature Communications 2019; 10.1038/s41467-019-11456-7 Richmond RC, Anderson EL, Dashti HS et al. Investigating causal relations between sleep traits and risk of breast cancer in women: a Mendelian randomization study. British Medical Journal, 2019 Liu J*, Richmond RC*, Bowden J, Barry C, Dashti HS, Daghlas I, Lane JM, Jones SE, Wood AR, Frayling TM, Wright AK, Carr MJ, Anderson SG, Emsley R, Ray D, Weedon MN, Saxena R, Lawlor DA, Rutter MK. Assessing the causal role of sleep traits on glycated haemoglobin: a Mendelian randomization study. medRxiv https://doi.org/10.1101/2020.12.18.20224733 Daghlas I, Richmond RC, Dashti HS, Ollila H, Lane J, Schernhammer ES, Davey Smith G, Rutter MK, Saxena R, Vetter C. Mendelian randomization reveals a causal gradient of lower educational attainment and greater body mass index on selection into shift work. IJE 2021 Anderson EL, Richmond RC, Jones SE et al. Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis. IJE 2020 |
| Start Year | 2017 |
| Description | UK10K consortium |
| Organisation | EMBL European Bioinformatics Institute (EMBL - EBI) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Dr Josine Min; Contribution of data and research from the University of Bristol |
| Collaborator Contribution | Contribution of data and research from the University of Bristol |
| Impact | The Iotchkova et al and Haworth et al. manuscripts are outputs from the UK10K consortium. |
| Start Year | 2012 |
| Description | Welsh & Saleem (University of Bristol) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Aim is to investigate ability of 'omic profiles to predict response to treatment in nephrotic syndrome |
| Collaborator Contribution | Knowledge and experience with omic data, lab for DNA methylation generation |
| Impact | MRC PhD Fellowship (Samantha Hayward) |
| Start Year | 2018 |
| Description | Zeggini (Munich) |
| Organisation | Technical University of Munich |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Partner- Specialised knowledge of osteoarthritis, clinical samples, omic profiles. Aim is to unravel the genomic architecture of osteoarthritis by investigating multi-omic profiles of knee cartilage and synovium of individuals with and without osteoarthritis. |
| Collaborator Contribution | Knowledge and tools for analysing omic profiles. C Relton a member of the thesis committee of Peter Kreitmaier, a PhD student supervised by Prof Zeggini. |
| Impact | A few conference presentations and manuscripts in preparation. Annual thesis committee reports. This collaboration is multi-disciplinary involving rheumatology, human genetics, bioinformatics and population health/epidemiology |
| Start Year | 2019 |
| Description | Zhang - University of Memphis |
| Organisation | University of Memphis |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Collaborations with two groups concerned with molecular changes during puberty and their relation to asthma risk. My team has contributed to study design, data provision, data analysis and drafting of manuscripts. |
| Collaborator Contribution | Study design, data generation, writing of manuscripts, provision of funding. |
| Impact | Publications jointly co-authored by multi-disciplinary team including clinicians, statisticians and epigeneticists. Since last Researchfish submission: 34493871, 27040690, 34235211, 34995380, 33150670, 33407823, 33766110 |
| Start Year | 2015 |
| Title | Dmrff |
| Description | Identifies associations in genome-wide DNA methylation datasets with improved power while controlling error rates |
| Type Of Technology | Software |
| Year Produced | 2019 |
| Open Source License? | Yes |
| Impact | Used to analyse data in 14 published studies |
| URL | https://github.com/perishky/dmrff |
| Title | EWAS Catalog |
| Description | This webtool/application has curated all published epigenome-wide association studies (EWAS) (using the Illumina BeadChip platform) and incorporated them in to a searchable data base. This allows the user to locate any variable methylation probes they may be interested in in a similar way to the GWAS catalog for genetic variants. It provides a centralised repository and search tool for any investigator interested in EWAS. |
| Type Of Technology | Webtool/Application |
| Year Produced | 2018 |
| Open Source License? | Yes |
| Impact | The web application has just been released. It should have considerable impact across the research community as a browsing facility for all documented EWAS that appear in the published literature. |
| URL | http://www.ewascatalog.org |
| Description | APPG Medical Research |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | All Party Parliamentary Group on Medical Research |
| Year(s) Of Engagement Activity | 2022 |
| Description | Academy of Medical Sciences "Inspire" Showcase (Rebecca Richmond) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Undergraduate students |
| Results and Impact | Zoom lecture on molecular epidemiological research given to a representation of ~30 medical, dental and veterinary students in GW4 universities |
| Year(s) Of Engagement Activity | 2021 |
| Description | Bristol Covid-19 Health Protection Advisory Group |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | This multidisciplinary group of experts met monthly throughout the pandemic to assist the City Council in dispensing its public health duties. |
| Year(s) Of Engagement Activity | 2020,2021,2022 |
| Description | Building biosample based prospective cohorts in India |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | This workshop aimed to catalyse the creation and future application of a large population-based study in India. There has been continued involvement, inclusding the submission of related funding applications and the awarding of research funds to undertake an indoor air pollution study. |
| Year(s) Of Engagement Activity | 2019 |
| Description | COVID, education and schools |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Dr sarah Lewis has authored a series of blogs on issues around the impact of COVID-19 in the educational sector. These have included the perceived risk of schools opening and the risk of mortality in teachers compared to other professions. |
| Year(s) Of Engagement Activity | 2020,2021 |
| URL | https://ieureka.blogs.bristol.ac.uk/2020/12/15/covid19-should-schools-close-early-for-christmas/ |
| Description | Citizen Science Project - R.Richmond |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Rebecca Richmond has been involved in a Citizen Science project taking place as part of the SPHERE initiative which has involved engaging and working with members of the project as part of a participant-led research project around sleep. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Co-coordinator and lecturer on Swiss Epidemiology Winter School in 2019 - R.Richmond |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Rebecca Richmond presented a lecture to 20 Epidemiology students and researchers at the Swiss Epidemiology Winter School in 2019, this sparked discussions for future collaborations. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Conference presentation - ESHG Vienna 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | I gave a keynote lecture at an international conference |
| Year(s) Of Engagement Activity | 2022 |
| Description | Creative Reactions 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | I took part in Creative Reactions, an initiative that pairs scientists with artists to create artwork based on their academic research. I was paired with Olga Trevisan, an artist based in Venice, Italy. Based on some of my research around the Developmental Origins of Health and Disease, Olga created a piece called Beyond Question, which comments on the complexities of scientific data collection, bias and interpretation. Interesting conversations with people viewing the artwork revealed that some people's opinions (about the importance of the maternal contribution to offspring health, relative to paternal and wider societal influences) were challenged and changed. The artwork was displayed at two exhibitions at different sites in Bristol, with two separate launch events attended by the local media. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://epoch.blogs.bristol.ac.uk/2019/12/21/beyond-question-a-collaboration-between-epoch-and-artis... |
| Description | Curriculum enhancement materials for Key stages 3,4 and 5 |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | We developed a suite of curriculum enhancement materials (lesson plans and resources) based on COVID-19 for use by the schools involved in the CoMMinS study as well as any other school wishing to access these resources. The materials were developed through collaboration with an eductaional charity (IRIS) |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://commins.org.uk/school_staff/ |
| Description | Department for Education |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | We have established links with the Department for Education with whom we are discussing research priorities. The aim of this engagement is to ensure future research plans for CoMMInS are closely aligned with those of the DfE and therefore have potential for rapid policy translation. |
| Year(s) Of Engagement Activity | 2021 |
| Description | EMBL-EBI Human Ecosystems Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The event was aimed at developing and discussing input to the quinquennial EMBL-EBI strategic vision |
| Year(s) Of Engagement Activity | 2020 |
| Description | Education in our genes |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | This one day workshop was aimed at both social and biomedical scientists to present current developments around the application of genetic and epigenetic data in relation the educational attainment and related characteristics |
| Year(s) Of Engagement Activity | 2017 |
| Description | Epigenetic Clock Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | A one day workshop was held to present and discuss approaches to research using the epigenetic clock as a biomarker of biological age. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Epigenetic Epidemiology Bootcamp |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | I gave a keynote lecture followed by a Q&A session to an international course on epigenetic epidemiology hosted by Columbia University, USA. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Epigenomics and disease prediction |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | An invited talk at a symposium |
| Year(s) Of Engagement Activity | 2020 |
| Description | Epigenomics of Common Diseases Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker: Epigenomics of Common Disease Conference, Hinxton, Cambridge, UK. Nov 2021 |
| Year(s) Of Engagement Activity | 2021 |
| Description | Fun Palaces event planning - Rebecca Richmond |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Rebecca Richmond (ICEP Researcher) helped to organise a public engagement event relating to her e-cigarette study which was at Fun Palaces in Bristol in October 2017. Fun Palaces initiative is where community organisations lead events to connect public members with scientific research through creative interests or hobbies and expertise that may sit within those communities. The event allowed knowledge exchange between researchers and the public, informing about the demographic of e-cigarette use. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Greenman - R.Richmond |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Rebecca Richmond helped to organize and implement several public engagement activities in the "Einstein's Garden" of the Green Man Festival in 2018. More than 500 people attended. |
| Year(s) Of Engagement Activity | 2018 |
| Description | IGES conference - J.Staley |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | James Staley presented a conference poster to 250 people at the IGES Conference in San Diego, on the 18th October 2018. The poster/presentation is entitled: Longitudinal strategies for identifying genetic associations with epigenetic changes over time |
| Year(s) Of Engagement Activity | 2018 |
| Description | Inaugural Researchers' Summit for the new India-UK Cancer Research Initiative - C Relton |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof Caroline Relton (ICEP PI) was invited to attend the Inaugural Researchers' Summit for the new India-UK Cancer Research Initiative, a joint venture between Cancer Research UK and the Indian Government's Department of Biotechnology (DBT). This initiative seeks to establish new bilateral research alliances to undertake impactful research and develop innovative approaches to improving cancer outcomes. The Summit took place in New Delhi, India in November 2018 and brought together leading researchers, clinicians and technologists to identify the core research challenges under the broad theme of affordable approaches to cancer. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Inserm-EMBL |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker at Inserm-EMBL: 'Connecting molecular biology and epidemiology to study the exposome' Workshop. Paris, France Sep 2021 White paper on the role of the exposome as an environmental sensor is in preparation. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited speaker - Human Ecosystems seminar series EMBL |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | This hybrid event was aimed at a wide disciplinary audience of research and research support staff. It aimed to generate discussion and future planning on interdisciplinary research. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Meetings with MP |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | A series of meetings have been help with Thangam Debbonaire (MP, Bristol West) to discuss issues pertaining to the CoMMinS study. Advice was provided on stdy recruitment and contemprary issues around school closures and COVID-secure educational provision discussed. Information was shared with other constituency MPs in the city. |
| Year(s) Of Engagement Activity | 2020,2021 |
| Description | Molecular Epidemiology Group Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Annual scientific meeting of a multi-disciplinary academic group of international researchers |
| Year(s) Of Engagement Activity | 2019 |
| Description | New Horizons in Genomics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at a symposium. |
| Year(s) Of Engagement Activity | 2019 |
| Description | NutriPROGRAM Twitter |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | We have a NutriPROGRAM Twitter account with nearly 50 followers. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://twitter.com/nutriprogram |
| Description | Organize and lead the Science Focus Lab for Compass (University of Bristol EPSRC Centre for Doctoral Training in Computational Statistics and Data Science- M Suderman, P Yousefi, J Min |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Suderman, Yousefi and Min curated a dataset and wrote and presented a project proposal related to PhD students in the COMPASS programme. During the following two weeks, the students worked on the projects. At the end, the students presented and discussed their results with Suderman and Yousefi. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.bristol.ac.uk/cdt/compass |
| Description | Presentation at Nutrition Symposium, Erasmus - C Relton |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof Caroline Relton was invited to present at Nutrition Symposium, Erasmus Medical Center in June 2018. Prof Relton presented: Causal analysis in epigenetic epidemiology. The talk prompted the following exchange of letters: http://advances.sciencemag.org/content/4/1/eaao4364/tab-e-letters. The talk also raised the profile of Prof Relton and her research. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://advances.sciencemag.org/content/4/1/eaao4364/tab-e-letters |
| Description | Presentation at SER Annual Meeting (USA) - R Richmond |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr Rebecca Richmond was invited to give a talk at the Society for Epidemiologic Research (SER) annual meeting in Minneapolis, USA in June 2019. The presentation was entitled: Using Mendelian Randomization to understand how chronotype influences breast cancer risk. This talk raised the profile of Dr Richmond and her research. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Presentation at UCLA - R Richmond |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr Rebecca Richmond was invited to give a talk at the Department of Human Genetics Seminar Series, UCLA in Los Angeles, USA in September 2019. The presentation was entitled: Investigating the mediating role of molecular mechanisms in common complex disease using epidemiological tools. This talk raised the profile of Dr Richmond and her research. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Presentation at Ulster University - R Richmond |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr Rebecca Richmond was invited to give a talk at the Epigenetics in Health and Wellbeing Workshop at Ulster University, Northern Ireland in April 2019. The presentation was entitled: Epigenetics and Lifecourse Epidemiology. This talk raised the profile of Dr Richmond and her research. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Presentation at University of Edinburgh - R Richmond |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr Rebecca Richmond was invited to give a talk at the Division of Psychiatry Seminar Series, University of Edinburgh in August 2019. The presentation was entitled: Smoking, DNA methylation and lung function: A Mendelian randomization analysis to investigate causal relationships. This talk raised the profile of Dr Richmond and her research. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Presented 'Longitudinal DNA methylation and other omics in ALSPAC' to the virtual Illumina Users Group meeting (Mar 15, 2022) - Suderman |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Suderman presented what has been learned from omic data in ALSPAC and potential for further analyses. The presentation was followed by discussion with the audience. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Richard Doll Seminar in Public Health & Epidemiology (University of Oxford) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | A formal seminar. Additional collaborative activity arose following the visit. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Statistics in Epigenetics Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | A one day workshop was held to describe and discuss recent key statistical advances for analysing DNA methylation data funded by an MRC grant. A keynote lecture was also given on the 'Estimation of a significance threshold for epigenome-wide association studies'. Over 60 post-grad students, fellow researchers, and health professionals attended this free workshop. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.eventbrite.co.uk/e/epigenetics-statistics-workshop-tickets-49889050493 |
| Description | The Cell's Cancer Short course event, University of Bristol, March 2021 (Rebecca Richmond) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | Zoom lecture on molecular epidemiological research in cancer given to "The Cell", a representation of ~30 students studying Cellular and Molecular Medicine at the University of Bristol. |
| Year(s) Of Engagement Activity | 2021 |
| Description | UK Clock Club: Virtual Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Virtual conference attended by >100 sleep and circadian biology researchers |
| Year(s) Of Engagement Activity | 2020 |
| Description | Visit to Barshi, India - C Relton |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Professors Caroline Relton and George Davey Smith went to Barshi, India in May 2018. They visited the India Study for Health of Adults (Barshi Cohort Study) in action and the TATA Memorial Centre. Their trip included presenting to villages who were cohort participants and visiting the field site of the Barshi cohort. Future collaborations between Bristol and the TATA team were discussed. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Wellcome Training Workshop at OUCRU - C Relton |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Prof Caroline Relton (ICEP PI) visited OUCRU (Oxford University Clinical Research Unit) in Ho Chi Minh City and Hanoi, Vietnam for a week in April 2018. The workshops were set up by the Wellcome Trust, where Prof Relton delivered training in group leadership, the process of peer review, grant writing and career development to Wellcome-funded researchers of all stages based there. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Workshop on Osteoporosis Functional Genomics |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Workshop on Osteoporosis Functional Genomics, organised by the Osteoporosis and Bone research Academy of the Royal Osteoporosis Society. |
| Year(s) Of Engagement Activity | 2020 |