Enabling technologies
Lead Research Organisation:
University of Cambridge
Department Name: UNLISTED
Abstract
The Enabling Technologies programme consists of a number of core facilities that provide critical technologies and equipment to scientists in the MDU and it is crucial its success. Because metabolic disease affects the entire body, it is vital to study these diseases whole animals. Our model of choice is the mouse. The Disease Model Core provides facilities for the measurement of the amount of fat and muscle in an animal’s body, how much and what type of food is eaten, and how much energy is burnt, through either metabolism, heat production, or exercise. It also provides facilities for examining isolated cells, tissues and organs. At the other end of the size spectrum, the Genomics/Transcriptomics Core enables scientists to study the sub-microscopic world of genes and how they function and are turned into proteins and the Core Biochemistry Assay Lab measures hormones and other molecules in blood.
Technical Summary
This programme provides the core facilities and technologies that act as vital supporting infrastructure, not only for MDU Programmes 1-4 but also for the other investigators across the MRL. At the heart of this programme are the Disease Model Core (DMC), the Genomics and Transcriptomics Core (GTC) and the Biochemistry Assay Lab (CBAL).
The DMC integrates two major platforms, physiology and histology, and provides a full range of support services to maximise scientific output from in vivo model systems. These include Home Office licensing support, cutting-edge in vivo phenotyping techniques, ex vivo tissue analysis, statistical analysis and data interpretation. The GTC provides access to high-throughput sequencing technologies, RNA quantification and ‘Sanger’ DNA sequencing as well as bioinformatics support. CBAL runs alongside the Clinical Biochemistry Lab of the Cambridge NIHR Cambridge Biomedical Research Centre and offers biochemical and immunoassay analyses (mainly rodent plasma and serum) to members of the MDU and IMS-MRL.
While the DMC and GTC are the primary facilities within Programme 5, a number of other key technologies, which receive the majority of their funding from other sources (Wellcome Trust and NIHR BRC), also provide critical support to MDU scientists. These are Microscopy and Imaging, Metabolomics/Lipidomics, Proteomics and the Genome Engineering Core. We seek to build on the success of these cores facilities and strengthen key areas where there is pressing, multi-user need.
The DMC integrates two major platforms, physiology and histology, and provides a full range of support services to maximise scientific output from in vivo model systems. These include Home Office licensing support, cutting-edge in vivo phenotyping techniques, ex vivo tissue analysis, statistical analysis and data interpretation. The GTC provides access to high-throughput sequencing technologies, RNA quantification and ‘Sanger’ DNA sequencing as well as bioinformatics support. CBAL runs alongside the Clinical Biochemistry Lab of the Cambridge NIHR Cambridge Biomedical Research Centre and offers biochemical and immunoassay analyses (mainly rodent plasma and serum) to members of the MDU and IMS-MRL.
While the DMC and GTC are the primary facilities within Programme 5, a number of other key technologies, which receive the majority of their funding from other sources (Wellcome Trust and NIHR BRC), also provide critical support to MDU scientists. These are Microscopy and Imaging, Metabolomics/Lipidomics, Proteomics and the Genome Engineering Core. We seek to build on the success of these cores facilities and strengthen key areas where there is pressing, multi-user need.
Organisations
- University of Cambridge (Lead Research Organisation)
- Royal Netherlands Academy of Arts and Sciences (Collaboration)
- University of Copenhagen (Collaboration)
- California Institute of Technology (Collaboration)
- Nanjing University (NJU) (Collaboration)
- Microsoft Research (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
- French National Institute of Agricultural Research (Collaboration)
- AstraZeneca (United Kingdom) (Collaboration)
- University of Ulster (Collaboration)
- University of Montreal (Collaboration)
- LGC Ltd (Collaboration)
- Addenbrooke's Hospital (Collaboration)
- University of Toronto (Collaboration)
- VTT Technical Research Centre of Finland Ltd (Collaboration)
- Model Animal Research Center (MARC) Nanjing (Collaboration)
People |
ORCID iD |
Publications
Vidal-Puig A
(2018)
"Obesity-associated metabolic complications, the second wave of the tsunami" 14th Key Symposium.
in Journal of internal medicine
Carobbio S
(2018)
'Basic and Applied Thermogenesis Research' Bridging the Gap.
in Trends in endocrinology and metabolism: TEM
Grandoch M
(2019)
4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue.
in Nature metabolism
Lotta LA
(2021)
A cross-platform approach identifies genetic regulators of human metabolism and health.
in Nature genetics
Nasrallah R
(2020)
A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by Treg cells.
in Nature
Furse S
(2020)
A high-throughput platform for detailed lipidomic analysis of a range of mouse and human tissues.
in Analytical and bioanalytical chemistry
Related Projects
| Project Reference | Relationship | Related To | Start | End | Award Value |
|---|---|---|---|---|---|
| MC_UU_00014/1 | 01/04/2018 | 31/03/2024 | £2,995,583 | ||
| MC_UU_00014/2 | Transfer | MC_UU_00014/1 | 01/04/2018 | 31/03/2024 | £2,871,979 |
| MC_UU_00014/3 | Transfer | MC_UU_00014/2 | 01/04/2018 | 31/03/2024 | £1,667,444 |
| MC_UU_00014/4 | Transfer | MC_UU_00014/3 | 01/04/2018 | 31/03/2024 | £1,743,788 |
| MC_UU_00014/5 | Transfer | MC_UU_00014/4 | 01/04/2018 | 31/03/2024 | £3,355,490 |
| MC_UU_00014/6 | Transfer | MC_UU_00014/5 | 01/04/2018 | 31/03/2024 | £1,325,715 |
| Description | ADHERENCE THROUGH CLOUD-BASED PERSONALISED TREATMENT FOR TYPE 2 DIABETES - ADAPTT2D (TRY 3) |
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| Organisation | Innovation Fund Denmark |
| Sector | Public |
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| Start | 08/2019 |
| End | 08/2024 |
| Description | AK, HUMAN DRIED BLOOD SPOTS, HUMAN PLASMA, MOUSE TISSUES (NAFLD) |
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| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2020 |
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| Description | Academy of Medical Sciences Clinical Lecturer Starter Grant (30,000) |
| Amount | £30,000 (GBP) |
| Organisation | Academy of Medical Sciences (AMS) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 12/2019 |
| Description | CM, ASSOCIATION OF PHYSICIANS OF GB & IRELAND |
| Amount | £19,996 (GBP) |
| Organisation | Association of Physicians of Great Britain and Ireland |
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| End | 03/2022 |
| Description | Cellular mechanisms of metabolic sensing by human hypothalamic neurons |
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| Country | United Kingdom |
| Start | 04/2018 |
| End | 03/2019 |
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| Amount | £1,601,656 (GBP) |
| Funding ID | 210775/z/18/z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2018 |
| End | 07/2023 |
| Description | ER, BRITISH SOCIETY FOR NEUROENDOCRINOLOGY |
| Amount | £2,120 (GBP) |
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| Sector | Charity/Non Profit |
| Country | United Kingdom |
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| End | 08/2019 |
| Description | Exploring sex specific programming ... |
| Amount | £43,656 (GBP) |
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| Department | European Foundation for the Study of Diabetes (EFSD) |
| Sector | Academic/University |
| Country | Germany |
| Start | 09/2018 |
| End | 04/2019 |
| Description | Exposure to maternal obesity ... |
| Amount | £27,839 (GBP) |
| Organisation | University of Cambridge |
| Department | Isaac Newton Trust |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 08/2018 |
| Description | FM, SILICON VALLEY COMMUNITY FOUNDATION |
| Amount | £1,937,983 (GBP) |
| Organisation | Silicon Valley Community Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 12/2018 |
| End | 11/2023 |
| Description | FR, Medimmune |
| Amount | £60,000 (GBP) |
| Organisation | AstraZeneca |
| Department | MedImmune |
| Sector | Private |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 09/2022 |
| Description | HYPOTHALAMIC MIR-505-5P AND MATERNAL OBESITY |
| Amount | £7,000 (GBP) |
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| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2020 |
| End | 08/2021 |
| Description | INVESTIGATION OF A NOVEL THERAPEUTIC TARGET IN XERODERMA PIGMENTOSUM |
| Amount | £16,000 (GBP) |
| Organisation | Addenbrooke's Charitable Trust (ACT) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 12/2019 |
| End | 06/2021 |
| Description | Insights into metabolic health and disease from human genetic variants with major functional impact |
| Amount | £1,894,039 (GBP) |
| Funding ID | 214274/Z/18/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2019 |
| End | 02/2024 |
| Description | Jo Lewis, BSN symposium support for Physiology 2019, Aberdeen, UK |
| Amount | £2,000 (GBP) |
| Organisation | British Society for Neuroendocrinology |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2019 |
| End | 01/2019 |
| Description | Jo Lewis, BSN symposium support for the ECR day at the BSN's annual conference, Glasgow, UK |
| Amount | £5,000 (GBP) |
| Organisation | British Society for Neuroendocrinology |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2019 |
| End | 01/2019 |
| Description | Jo Lewis, The Physiological Society satellite support for Physiology 2019, Aberdeen, UK |
| Amount | £20,000 (GBP) |
| Organisation | Physiological Society |
| Sector | Charity/Non Profit |
| Country | Global |
| Start | 08/2019 |
| End | 08/2019 |
| Description | Jo Lewis, The Physiological Society symposium support for Experimental Biology, Orlando, |
| Amount | £2,000 (GBP) |
| Organisation | Physiological Society |
| Sector | Charity/Non Profit |
| Country | Global |
| Start | 06/2019 |
| End | 06/2019 |
| Description | Litmus IMI |
| Amount | € 16,000,000 (EUR) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 01/2018 |
| End | 12/2022 |
| Description | MECHANISMS OF ENDOMETRIAL DYSFUNCTION AND CANCER IN OBESITY |
| Amount | £10,000 (GBP) |
| Organisation | Addenbrooke's Charitable Trust (ACT) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2020 |
| End | 06/2021 |
| Description | MODELLING OBESITY-ASSOCIATED LIVER DISEASE USING STEM CELL DERIVED HEPATIC ORGANOIDS |
| Amount | £20,000 (GBP) |
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| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2020 |
| End | 08/2022 |
| Description | MRC rapid response award (MC_PC_20047) |
| Amount | £95,000 (GBP) |
| Funding ID | MC_PC_20047 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2021 |
| End | 04/2021 |
| Description | Mapping the hypothalamic architecture underlying appetite control in the Prader Willi brain |
| Amount | $162,000 (USD) |
| Organisation | Foundation for Prader-Willi Research (FPWR) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2023 |
| End | 11/2024 |
| Description | Mason Medical Research Grant (15,000) |
| Amount | £15,000 (GBP) |
| Organisation | Mason Medical Research Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 12/2018 |
| Description | Molecular characterization in human neurons of genes associated with severe obesity identified from consanguineous pedigrees. |
| Amount | £1,014,003 (GBP) |
| Funding ID | MR/S026193/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 09/2022 |
| Description | Molecular mechanisms of impaired glucose transport in insulin resistance |
| Amount | £1,252,723 (GBP) |
| Funding ID | MR/S007091/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2019 |
| End | 05/2024 |
| Description | NOVO NORDISK UK RESEARCH FOUNDATION |
| Amount | £12,000 (GBP) |
| Organisation | Novo Nordisk Foundation |
| Sector | Charity/Non Profit |
| Country | Denmark |
| Start | 08/2018 |
| End | 01/2020 |
| Description | NS, wellcome senior fellowship |
| Amount | £1,758,388 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2020 |
| End | 03/2025 |
| Description | Programme Leader Track position at the MRC Metabolic Disease Unit |
| Amount | £16,560,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 04/2023 |
| Description | Programme grant |
| Amount | £1,245,413 (GBP) |
| Funding ID | RG/18/7/33636 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2018 |
| End | 05/2023 |
| Description | RH, UNIVERSITY OF EAST ANGLIA (FB NIHR) |
| Amount | £53,253 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 12/2021 |
| Description | Role of monocyte metabolism and signaling in NASH |
| Amount | £30,000 (GBP) |
| Funding ID | SGL018\1039 |
| Organisation | Academy of Medical Sciences (AMS) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2018 |
| End | 02/2020 |
| Description | SF, Evelyn trust |
| Amount | £10,000 (GBP) |
| Organisation | The Evelyn Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2019 |
| End | 07/2021 |
| Description | Targeting macrophage lipid metabolism to dissociate obesity from cardiovascular risk (renewal) |
| Amount | £1,245,413 (GBP) |
| Funding ID | RG/18/7/33636 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2018 |
| End | 05/2023 |
| Description | The Genetic Basis of Congenital Hypothyroidism |
| Amount | £214,297 (GBP) |
| Funding ID | 100585/Z/12/A |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2018 |
| End | 10/2019 |
| Description | Understanding and disrupting the link between obesity and metabolic disease |
| Amount | £1,944,579 (GBP) |
| Funding ID | 219417/Z/19/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2020 |
| End | 09/2025 |
| Description | WHAT MECHANISMS LINK ANTHROPOMETRIC STATUS WITH RISK OF DEATH IN HOSPITAL AND AFTER DISCHARGE - THE CHAIN STUDY |
| Amount | £76,125 (GBP) |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 01/2020 |
| End | 12/2020 |
| Description | Wellcome Trust Major Award |
| Amount | £5,044,481 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 03/2023 |
| Description | closed loop insulin delivery in adults with type 2 diabetes |
| Amount | £11,976 (GBP) |
| Organisation | Novo Nordisk |
| Sector | Private |
| Country | Denmark |
| Start | 08/2018 |
| End | 01/2020 |
| Description | cm, BMA FOUNDATION FOR MEDICAL RESEARCH |
| Amount | £28,000 (GBP) |
| Organisation | British Medical Association (BMA) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 08/2022 |
| Description | cm, NOVO NORDISK FONDEN |
| Amount | £573,325 (GBP) |
| Organisation | Novo Nordisk Foundation |
| Sector | Charity/Non Profit |
| Country | Denmark |
| Start | 11/2019 |
| End | 10/2024 |
| Description | fm, NEW YORK STEM CELL FOUNDATION |
| Amount | £1,229,507 (GBP) |
| Organisation | New York Stem Cell Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 01/2020 |
| End | 12/2024 |
| Description | fm, SILICON VALLEY COMMUNITY FOUNDATION 1 |
| Amount | £3,968 (GBP) |
| Organisation | Silicon Valley Community Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 11/2019 |
| End | 10/2020 |
| Description | gy, NOVO NORDISK A/S |
| Amount | £56,700 (GBP) |
| Organisation | Novo Nordisk |
| Sector | Private |
| Country | Denmark |
| Start | 10/2019 |
| End | 09/2023 |
| Description | human cellular models of hypothalamic metabolic sensing... |
| Amount | £1,212,840 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 08/2023 |
| Description | hypoglycaemia: redefining solutions |
| Amount | £565,666 (GBP) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 05/2018 |
| End | 04/2022 |
| Description | imterventions during obese pregnancy |
| Amount | £200,000 (GBP) |
| Organisation | Nutricia BV |
| Sector | Private |
| Country | Netherlands |
| Start | 05/2018 |
| End | 05/2019 |
| Description | me, NOVO NORDISK A/S |
| Amount | £133,762 (GBP) |
| Organisation | Novo Holdings A/S |
| Sector | Private |
| Country | Denmark |
| Start | 10/2019 |
| End | 09/2022 |
| Description | ns, BRITISH THYROID FOUNDATION |
| Amount | £20,000 (GBP) |
| Organisation | British Thyroid Foundation (BTF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2019 |
| End | 06/2020 |
| Description | resloving uncertainties in diagnosis and management of thyroid hormone... |
| Amount | £10,000 (GBP) |
| Organisation | Society for Endocrinology |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2018 |
| End | 01/2019 |
| Description | rh, MANCHESTER UNIVERSITY NHS FOUNDATION TRUST (FB NOVO NORDISK LTD) |
| Amount | £20,190 (GBP) |
| Organisation | Novo Nordisk |
| Sector | Private |
| Country | Denmark |
| Start | 06/2019 |
| End | 05/2022 |
| Description | targetting macrophage lipid metabolism |
| Amount | £1,255,413 (GBP) |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2018 |
| End | 05/2023 |
| Description | tvp, az |
| Amount | £86,956 (GBP) |
| Organisation | AstraZeneca |
| Sector | Private |
| Country | United Kingdom |
| Start | 06/2019 |
| End | 10/2022 |
| Title | High-throughput single cell unbiased lipidomics assay in human iPSC-derived dopamine neurons (AK) |
| Description | The development of single cell lipidomics approaches to study the lipid metabolism of dopaminergic neurons in relation to parkinson's disease. Changes in lipid metabolism have been strongly associated with Parkinson's disease (PD). Lipids have the potential to be important biomarkers for PD, but the lack of appropriate tools to measure total lipids (lipidome) in human dopamine neurons has limited advances in this field. we have developed a novel unbiased and high-throughput single cell assay to determine total lipids. This will allow us to identify and validate lipid metabolites in dopamine neurons, which may serve as biomarkers for PD. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2020 |
| Provided To Others? | No |
| Impact | project is ongoing |
| URL | https://www.michaeljfox.org/grant/measuring-lipids-ipsc-derived-dopamine-neurons-identify-parkinsons... |
| Title | bioinformatic pipeline for analysis of sequencing data from gene-edited cell lines (FM) |
| Description | CRISPR is a powerful way to edit stem cell clones, but identifying cell clones carrying desired edits remains challenging. To address this issue we developed GenEditID, a flexible, open-access platform for sample tracking, analysis and integration of multiplexed deep sequencing and proteomic data, and intuitive plate-based data visualisation to facilitate gene edited clone identification. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | The impact of this work is not immediately clear, but our hope is that it will facilitate other groups and facilities to establish their own high-throughput gene editing workflows. |
| URL | https://www.biorxiv.org/content/10.1101/657650v1 |
| Description | Brubaker lab |
| Organisation | University of Toronto |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | Mouse models and discussion |
| Collaborator Contribution | Experimentation and project design |
| Impact | Publication |
| Start Year | 2015 |
| Description | G/R Bertie Goettgens, Single Cell RNAseq |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Experiments |
| Collaborator Contribution | Experiments |
| Impact | none yet |
| Start Year | 2015 |
| Description | GIP receptor localisation and function |
| Organisation | University of Toronto |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | We generated a gipr knockin mouse, which has been shipped to Toronto |
| Collaborator Contribution | Analysis of the genetically modified mouse in Toronto |
| Impact | None to date |
| Start Year | 2016 |
| Description | Gastrectomy clinicians |
| Organisation | Addenbrooke's Hospital |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Physiological studies on humans after gastrectomy plus in vitro analysis of tissue samples |
| Collaborator Contribution | Identification of suitable patients |
| Impact | Publications |
| Start Year | 2015 |
| Description | Generation of organoids from transgenic models |
| Organisation | Royal Netherlands Academy of Arts and Sciences |
| Department | Hubrecht Institute |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We provided tissue from transgenic mouse models |
| Collaborator Contribution | Collaborators will generate organoids for use in their research programme |
| Impact | None to date |
| Start Year | 2016 |
| Description | Holst perfused pancreas |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Ideas for experiments |
| Collaborator Contribution | Perfused pancreas to test ideas developed in Cambridge |
| Impact | Publication |
| Start Year | 2015 |
| Description | Joint Unit CIPF-CAMBRIDGE Obesity and Metabolic Regulation |
| Organisation | Microsoft Research |
| Department | Microsoft Research Cambridge |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Genetic engineering of human pluripotent stem cells |
| Collaborator Contribution | Validation of Phenotyping of cells (CIPF). KAUST (AI Application to identify reposition of compounds) Microsoft Cambridge (Bioinformatic Analysis) Cite s |
| Impact | Generation of gene-corrected human induced pluripotent stem cell lines derived from retinitis pigmentosa patient with Ser331Cysfs*5 mutation in MERTK. Artero Castro A, Long K, Bassett A, Machuca C, León M, Ávila-Fernandez A, Cortón M, Vidal-Puig T, Ayuso C, Lukovic D, Erceg S. Stem Cell Res. 2019 Jan;34:101341. doi: 10.1016/j.scr.2018.11.003. Epub 2018 Nov 16. PMID: 30612079 Free Article Artero Castro A, Long K, Bassett A, Machuca C, León M, Ávila-Fernandez A, Cortón M, Vidal-Puig T, Ayuso C, Lukovic D, Erceg S.Generation of gene-corrected human induced pluripotent stem cell lines derived from retinitis pigmentosa patient with Ser331Cysfs*5 mutation in MERTK Stem Cell Res. 2019 Jan;34:101341. doi: 10.1016/j.scr.2018.11.003. Epub 2018 Nov 16. PMID: 30612079 Free article. 2 Carobbio S, Guenantin AC, Bahri M, Rodriguez-Fdez S, Honig F, Kamzolas I, Samuelson I, Long K, Awad S, Lukovic D, Erceg S, Bassett A, Mendjan S, Vallier L, Rosen BS, Chiarugi D, Vidal-Puig A.Unraveling the developmental roadmap toward human brown adipose tissue. Stem Cell Reports. 2021 Feb 6:S2213-6711(21)00043-6. doi: 10.1016/j.stemcr.2021.01.013. Online ahead of print. PMID: 33606988 Free article.enetic engineering of Cell |
| Start Year | 2017 |
| Description | LGC peptidomics |
| Organisation | LGC Ltd |
| Country | Global |
| Sector | Private |
| PI Contribution | Supporting a BBSRC iCASE studentship |
| Collaborator Contribution | Analysis and training |
| Impact | One publication to date |
| Start Year | 2017 |
| Description | Larraufie Paris lab |
| Organisation | French National Institute of Agricultural Research |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Experimentation |
| Collaborator Contribution | Experimentation and project planning |
| Impact | Publications |
| Start Year | 2016 |
| Description | Lipidomic analysis in the context of lipotoxicity |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have provided biological samples for lipidomic analysis and the intellectual background to justify this programme of research. |
| Collaborator Contribution | The lab of Prof Matej Oresic has performed lipidomic analysis in murine tissues from our genetically modified models. Our models have provided biological material for analytical platform development. Funding forthis experiments has been provided through collaborative FP6 Hepadip and FP7 Etherpath grants. Continued collaboration with Horizon 2020 Epoos and IMI Litmus |
| Impact | Govaere O, Cockell S, Tiniakos D, Queen R, Younes R, Vacca M, Alexander L, Ravaioli F, Palmer J, Petta S, Boursier J, Rosso C, Johnson K, Wonders K, Day CP, Ekstedt M, Orešic M, Darlay R, Cordell HJ, Marra F, Vidal-Puig A, Bedossa P, Schattenberg JM, Clément K, Allison M, Bugianesi E, Ratziu V, Daly AK, Anstee QMTranscriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis.Sci Transl Med. 2020 Dec 2;12(572):eaba4448. doi: 10.1126/scitranslmed.aba4448. PMID: 33268509 Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity. Petkevicius K, Virtue S, Bidault G, Jenkins B, Çubuk C, Morgantini C, Aouadi M, Dopazo J, Serlie MJ, Koulman A, Vidal-Puig A. Elife. 2019 Aug 16;8:e47990. doi: 10.7554/eLife.47990. PMID: 31418690 Free PMC article. 2 Cite Share Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL. Hepatology. 2017 Apr;65(4):1165-1180. doi: 10.1002/hep.28953. Epub 2017 Feb 6. PMID: 27863448 Free PMC article. 3 Cite Share Peroxisome Proliferator-Activated Receptor ?2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility. Virtue S, Petkevicius K, Moreno-Navarrete JM, Jenkins B, Hart D, Dale M, Koulman A, Fernández-Real JM, Vidal-Puig A. Cell Rep. 2018 Aug 21;24(8):2005-2012.e7. doi: 10.1016/j.celrep.2018.07.063. PMID: 30134163 Free PMC article. 4 Cite Share Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption. Sanders FWB, Acharjee A, Walker C, Marney L, Roberts LD, Imamura F, Jenkins B, Case J, Ray S, Virtue S, Vidal-Puig A, Kuh D, Hardy R, Allison M, Forouhi N, Murray AJ, Wareham N, Vacca M, Koulman A, Griffin JL. Genome Biol. 2018 Jun 20;19(1):79. doi: 10.1186/s13059-018-1439-8. PMID: 29925420 Free PMC article. 5 Cite Share Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation. Petkevicius K, Bidault G, Virtue S, Jenkins B, van Dierendonck XAMH, Dugourd A, Saez-Rodriguez J, Stienstra R, Koulman A, Vidal-Puig A. FASEB J. 2021 Feb;35(2):e21266. doi: 10.1096/fj.202001101R. PMID: 3348419 Barbarroja N, Rodriguez-Cuenca S, Nygren H, Camargo A, Pirraco A, Relat J, Cuadrado I, Pellegrinelli V, Medina-Gomez G, Lopez-Pedrera C, Tinahones FJ, Symons JD, Summers SA, Oresic M, Vidal-Puig A.Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function.Diabetes. 2015 Apr;64(4):1180-92. doi: 10.2337/db14-0359. Epub 2014 Oct 28. PMID: 25352638 Free Article << First< PrevPage of 2Next >Last >> Select item 28683288 1.Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešic M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M. Cell Metab. 2017 Jul 5;26(1):212-229.e12. doi: 10.1016/j.cmet.2017.06.014. PMID: 28683288 Free PMC Article Similar articles Select item 28104532 2.Sphingolipids and glycerophospholipids - The "ying and yang" of lipotoxicity in metabolic diseases. Rodriguez-Cuenca S, Pellegrinelli V, Campbell M, Oresic M, Vidal-Puig A. Prog Lipid Res. 2017 Apr;66:14-29. doi: 10.1016/j.plipres.2017.01.002. Epub 2017 Jan 16. Review. PMID: 28104532 Similar articles Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity. Carobbio S, Hagen RM, Lelliott CJ, Slawik M, Medina-Gomez G, Tan CY, Sicard A, Atherton HJ, Barbarroja N, Bjursell M, Bohlooly-Y M, Virtue S, Tuthill A, Lefai E, Laville M, Wu T, Considine RV, Vidal H, Langin D, Oresic M, Tinahones FJ, Fernandez-Real JM, Griffin JL, Sethi JK, López M, Vidal-Puig A.Diabetes. 2013 Nov;62(11):3697-708. doi: 10.2337/db12-1748. Epub 2013 Aug 6. PMID: 23919961 Free PMC Article Virtue S, Masoodi M, Velagapudi V, Tan CY, Dale M, Suorti T, Slawik M, Blount M, Burling K, Campbell M, Eguchi N, Medina-Gomez G, Sethi JK, Orešic M, Urade Y, Griffin JL, Vidal-PuigLipocalin prostaglandin D synthase and PPAR?2 coordinate to regulate carbohydrate and lipid metabolism in vivo.A.PLoS One. 2012;7(7):e39512. doi: 10.1371/journal.pone.0039512. Epub 2012 Jul 5. PMID: 22792179 Free PMC Article1. Prieur X, Mok CY, Velagapudi VR, Núñez V, Fuentes L, Montaner D, Ishikawa K, Camacho A, Barbarroja N, O'Rahilly S, Sethi J, Dopazo J, Oresic M, Ricote M, Vidal-Puig A. Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1 Polarization in Obese Mice. Diabetes Jan 24, 2011. Pietiläinen KH, Róg T, Seppänen-Laakso T, Virtue S, Gopalacharyulu P, Tang J, Rodriguez-Cuenca S, Maciejewski A, Naukkarinen J, Ruskeepää AL, Niemelä PS, Yetukuri L, Tan CY, Velagapudi V, Castillo S, Nygren H, Hyötyläinen T, Rissanen A, Kaprio J, Yki-Järvinen H, Vattulainen I, Vidal-Puig A, Orešic M. Association of lipidome remodelling in the adipocyte membrane with acquired obesity in humans. PLoS Biol June 7, 2011. 1.Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. 3. López M, Varela L, Vázquez MJ, Rodríguez-Cuenca S, González CR, Velagapudi VR, Morgan DA, Schoenmakers E, Agassandian K, Lage R, Martínez de Morentin PB, Tovar S, Nogueiras R, Carling D, Lelliott C, Gallego R, Oresic M, Chatterjee K, Saha AK, Rahmouni K, Diéguez C, Vidal-Puig A.Nat Med. 2010 Sep;16(9):1001-8. Epub 2010 Aug 29. PMID: 20802499 [PubMed - indexed for MEDLINE]Related citations Lagathu C, Christodoulides C, Tan CY, Virtue S, Laudes M, Campbell M, Ishikawa K, Ortega F, Tinahones FJ, Fernández-Real JM, Orešic M, Sethi JK, Vidal-Puig A.4.Secreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity. Int J Obes (Lond). 2010 Jun 1. PMID: 20514047 [PubMed - as supplied by publisher] 5.Medina-Gomez G, Yetukuri L, Velagapudi V, Campbell M, Blount M, Jimenez-Linan M, Ros M, Oresic M, Vidal-Puig A. Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome. Dis Model Mech. 2009 Nov-Dec;2(11-12):582-92. Epub 2009 Oct 19. PMID: 19841237 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text Tang J, Tan CY, Oresic M, Vidal-Puig .Integrating post-genomic approaches as a strategy to advance our understanding of health and disease. Genome Med. 2009 Mar 30;1(3):35.PMID: 19341506 [PubMed - in process]Free PMC ArticleFree text Tang J, Tan CY, Oresic M, Vidal-Puig A.Lipidomics: a new window to biomedical frontiers. Trends Biotechnol. 2008 Dec;26(12):647-52. Epub 2008 Oct 23. PMID: 18951641 [PubMed - indexed for MEDLINE] . Yetukuri L, Ekroos K, Vidal-Puig A, Oresic M.8.Informatics and computational strategies for the study of lipids Mol Biosyst. 2008 Feb;4(2):121-7. Epub 2007 Dec 18. Review. PMID: 18213405 [PubMed - indexed for MEDLINE] Related citations 9.PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GS, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M, Vidal-Puig A. PLoS Genet. 2007 Apr 27;3(4):e64. PMID: 17465682 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text Related citations 10.Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis. Yetukuri L, Katajamaa M, Medina-Gomez G, Seppänen-Laakso T, Vidal-Puig A, Oresic M. BMC Syst Biol. 2007 Feb 15;1:12. PMID: 17408502 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text Related citations 11.Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A. PLoS Biol. 2006 Nov;4(11):e369. PMID: 17090215 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text Related citations 12.Metabolomic approaches to phenotype characterization and applications to complex diseases. Oresic M, Vidal-Puig A, Hänninen V. Expert Rev Mol Diagn. 2006 Jul;6(4):575-85. Review. PMID: 16824031 [PubMed - indexed for MEDLINE] Related citations 13.Pathways to the analysis of microarray data. Curtis RK, Oresic M, Vidal-Puig A. Trends Biotechnol. 2005 Aug;23(8):429-35. Review. PMID: 15950303 [PubMed - indexed for MEDLINE] Related citations 14.The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform. 15.Medina-Gomez G, Virtue S, Lelliott C, Boiani R, Campbell M, Christodoulides C, Perrin C, Jimenez-Linan M, Blount M, Dixon J, Zahn D, Thresher RR, Aparicio S, Carlton M, Colledge WH, Kettunen MI, Seppänen-Laakso T, Sethi JK, O'Rahilly S, Brindle K, Cinti S, Oresic M, Burcelin R, Vidal-Puig A. Diabetes. 2005 Jun;54(6):1706-16. PMID: 15919792 [PubMed - indexed for MEDLINE]Free Article Related citations |
| Description | Lipidomic analysis in the context of lipotoxicity |
| Organisation | VTT Technical Research Centre of Finland Ltd |
| Department | QBIX Group |
| Country | Finland |
| Sector | Private |
| PI Contribution | We have provided biological samples for lipidomic analysis and the intellectual background to justify this programme of research. |
| Collaborator Contribution | The lab of Prof Matej Oresic has performed lipidomic analysis in murine tissues from our genetically modified models. Our models have provided biological material for analytical platform development. Funding forthis experiments has been provided through collaborative FP6 Hepadip and FP7 Etherpath grants. Continued collaboration with Horizon 2020 Epoos and IMI Litmus |
| Impact | Govaere O, Cockell S, Tiniakos D, Queen R, Younes R, Vacca M, Alexander L, Ravaioli F, Palmer J, Petta S, Boursier J, Rosso C, Johnson K, Wonders K, Day CP, Ekstedt M, Orešic M, Darlay R, Cordell HJ, Marra F, Vidal-Puig A, Bedossa P, Schattenberg JM, Clément K, Allison M, Bugianesi E, Ratziu V, Daly AK, Anstee QMTranscriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis.Sci Transl Med. 2020 Dec 2;12(572):eaba4448. doi: 10.1126/scitranslmed.aba4448. PMID: 33268509 Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity. Petkevicius K, Virtue S, Bidault G, Jenkins B, Çubuk C, Morgantini C, Aouadi M, Dopazo J, Serlie MJ, Koulman A, Vidal-Puig A. Elife. 2019 Aug 16;8:e47990. doi: 10.7554/eLife.47990. PMID: 31418690 Free PMC article. 2 Cite Share Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL. Hepatology. 2017 Apr;65(4):1165-1180. doi: 10.1002/hep.28953. Epub 2017 Feb 6. PMID: 27863448 Free PMC article. 3 Cite Share Peroxisome Proliferator-Activated Receptor ?2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility. Virtue S, Petkevicius K, Moreno-Navarrete JM, Jenkins B, Hart D, Dale M, Koulman A, Fernández-Real JM, Vidal-Puig A. Cell Rep. 2018 Aug 21;24(8):2005-2012.e7. doi: 10.1016/j.celrep.2018.07.063. PMID: 30134163 Free PMC article. 4 Cite Share Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption. Sanders FWB, Acharjee A, Walker C, Marney L, Roberts LD, Imamura F, Jenkins B, Case J, Ray S, Virtue S, Vidal-Puig A, Kuh D, Hardy R, Allison M, Forouhi N, Murray AJ, Wareham N, Vacca M, Koulman A, Griffin JL. Genome Biol. 2018 Jun 20;19(1):79. doi: 10.1186/s13059-018-1439-8. PMID: 29925420 Free PMC article. 5 Cite Share Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation. Petkevicius K, Bidault G, Virtue S, Jenkins B, van Dierendonck XAMH, Dugourd A, Saez-Rodriguez J, Stienstra R, Koulman A, Vidal-Puig A. FASEB J. 2021 Feb;35(2):e21266. doi: 10.1096/fj.202001101R. PMID: 3348419 Barbarroja N, Rodriguez-Cuenca S, Nygren H, Camargo A, Pirraco A, Relat J, Cuadrado I, Pellegrinelli V, Medina-Gomez G, Lopez-Pedrera C, Tinahones FJ, Symons JD, Summers SA, Oresic M, Vidal-Puig A.Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function.Diabetes. 2015 Apr;64(4):1180-92. doi: 10.2337/db14-0359. Epub 2014 Oct 28. PMID: 25352638 Free Article << First< PrevPage of 2Next >Last >> Select item 28683288 1.Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešic M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M. Cell Metab. 2017 Jul 5;26(1):212-229.e12. doi: 10.1016/j.cmet.2017.06.014. PMID: 28683288 Free PMC Article Similar articles Select item 28104532 2.Sphingolipids and glycerophospholipids - The "ying and yang" of lipotoxicity in metabolic diseases. Rodriguez-Cuenca S, Pellegrinelli V, Campbell M, Oresic M, Vidal-Puig A. Prog Lipid Res. 2017 Apr;66:14-29. doi: 10.1016/j.plipres.2017.01.002. Epub 2017 Jan 16. Review. PMID: 28104532 Similar articles Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity. Carobbio S, Hagen RM, Lelliott CJ, Slawik M, Medina-Gomez G, Tan CY, Sicard A, Atherton HJ, Barbarroja N, Bjursell M, Bohlooly-Y M, Virtue S, Tuthill A, Lefai E, Laville M, Wu T, Considine RV, Vidal H, Langin D, Oresic M, Tinahones FJ, Fernandez-Real JM, Griffin JL, Sethi JK, López M, Vidal-Puig A.Diabetes. 2013 Nov;62(11):3697-708. doi: 10.2337/db12-1748. Epub 2013 Aug 6. PMID: 23919961 Free PMC Article Virtue S, Masoodi M, Velagapudi V, Tan CY, Dale M, Suorti T, Slawik M, Blount M, Burling K, Campbell M, Eguchi N, Medina-Gomez G, Sethi JK, Orešic M, Urade Y, Griffin JL, Vidal-PuigLipocalin prostaglandin D synthase and PPAR?2 coordinate to regulate carbohydrate and lipid metabolism in vivo.A.PLoS One. 2012;7(7):e39512. doi: 10.1371/journal.pone.0039512. Epub 2012 Jul 5. PMID: 22792179 Free PMC Article1. Prieur X, Mok CY, Velagapudi VR, Núñez V, Fuentes L, Montaner D, Ishikawa K, Camacho A, Barbarroja N, O'Rahilly S, Sethi J, Dopazo J, Oresic M, Ricote M, Vidal-Puig A. Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1 Polarization in Obese Mice. Diabetes Jan 24, 2011. Pietiläinen KH, Róg T, Seppänen-Laakso T, Virtue S, Gopalacharyulu P, Tang J, Rodriguez-Cuenca S, Maciejewski A, Naukkarinen J, Ruskeepää AL, Niemelä PS, Yetukuri L, Tan CY, Velagapudi V, Castillo S, Nygren H, Hyötyläinen T, Rissanen A, Kaprio J, Yki-Järvinen H, Vattulainen I, Vidal-Puig A, Orešic M. Association of lipidome remodelling in the adipocyte membrane with acquired obesity in humans. PLoS Biol June 7, 2011. 1.Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. 3. López M, Varela L, Vázquez MJ, Rodríguez-Cuenca S, González CR, Velagapudi VR, Morgan DA, Schoenmakers E, Agassandian K, Lage R, Martínez de Morentin PB, Tovar S, Nogueiras R, Carling D, Lelliott C, Gallego R, Oresic M, Chatterjee K, Saha AK, Rahmouni K, Diéguez C, Vidal-Puig A.Nat Med. 2010 Sep;16(9):1001-8. Epub 2010 Aug 29. PMID: 20802499 [PubMed - indexed for MEDLINE]Related citations Lagathu C, Christodoulides C, Tan CY, Virtue S, Laudes M, Campbell M, Ishikawa K, Ortega F, Tinahones FJ, Fernández-Real JM, Orešic M, Sethi JK, Vidal-Puig A.4.Secreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity. Int J Obes (Lond). 2010 Jun 1. PMID: 20514047 [PubMed - as supplied by publisher] 5.Medina-Gomez G, Yetukuri L, Velagapudi V, Campbell M, Blount M, Jimenez-Linan M, Ros M, Oresic M, Vidal-Puig A. Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome. Dis Model Mech. 2009 Nov-Dec;2(11-12):582-92. Epub 2009 Oct 19. PMID: 19841237 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text Tang J, Tan CY, Oresic M, Vidal-Puig .Integrating post-genomic approaches as a strategy to advance our understanding of health and disease. Genome Med. 2009 Mar 30;1(3):35.PMID: 19341506 [PubMed - in process]Free PMC ArticleFree text Tang J, Tan CY, Oresic M, Vidal-Puig A.Lipidomics: a new window to biomedical frontiers. Trends Biotechnol. 2008 Dec;26(12):647-52. Epub 2008 Oct 23. PMID: 18951641 [PubMed - indexed for MEDLINE] . Yetukuri L, Ekroos K, Vidal-Puig A, Oresic M.8.Informatics and computational strategies for the study of lipids Mol Biosyst. 2008 Feb;4(2):121-7. Epub 2007 Dec 18. Review. PMID: 18213405 [PubMed - indexed for MEDLINE] Related citations 9.PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GS, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M, Vidal-Puig A. PLoS Genet. 2007 Apr 27;3(4):e64. PMID: 17465682 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text Related citations 10.Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis. Yetukuri L, Katajamaa M, Medina-Gomez G, Seppänen-Laakso T, Vidal-Puig A, Oresic M. BMC Syst Biol. 2007 Feb 15;1:12. PMID: 17408502 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text Related citations 11.Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A. PLoS Biol. 2006 Nov;4(11):e369. PMID: 17090215 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text Related citations 12.Metabolomic approaches to phenotype characterization and applications to complex diseases. Oresic M, Vidal-Puig A, Hänninen V. Expert Rev Mol Diagn. 2006 Jul;6(4):575-85. Review. PMID: 16824031 [PubMed - indexed for MEDLINE] Related citations 13.Pathways to the analysis of microarray data. Curtis RK, Oresic M, Vidal-Puig A. Trends Biotechnol. 2005 Aug;23(8):429-35. Review. PMID: 15950303 [PubMed - indexed for MEDLINE] Related citations 14.The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform. 15.Medina-Gomez G, Virtue S, Lelliott C, Boiani R, Campbell M, Christodoulides C, Perrin C, Jimenez-Linan M, Blount M, Dixon J, Zahn D, Thresher RR, Aparicio S, Carlton M, Colledge WH, Kettunen MI, Seppänen-Laakso T, Sethi JK, O'Rahilly S, Brindle K, Cinti S, Oresic M, Burcelin R, Vidal-Puig A. Diabetes. 2005 Jun;54(6):1706-16. PMID: 15919792 [PubMed - indexed for MEDLINE]Free Article Related citations |
| Description | Medimmune BBSRC iCASE (Galvin) |
| Organisation | AstraZeneca |
| Department | MedImmune |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Supervision of PhD student |
| Collaborator Contribution | Joint supervision of student, training, peptide synthesis |
| Impact | None yet |
| Start Year | 2016 |
| Description | NANJING/SUZHOU |
| Organisation | Model Animal Research Center (MARC) Nanjing |
| Country | China |
| Sector | Academic/University |
| PI Contribution | Provide expertise in murine metabolic phenotyping |
| Collaborator Contribution | Phenotyping of mice and PhD studentship |
| Impact | N/A • Prof. Antonio Vidal-Puig is a concurrent professor at Nanjing University appointed in September of 2017. • A joint lab focusing on non-alcoholic fatty liver disease has been established at MARC in 2017, co-headed by Profs. Antonio Vidal-Puig and Shuai Chen. • Strong collaborative links with professor Chen Yu Zhang at the Institute of Life Sciences of the University of Nanjing to identify mechanism of disease in metabolic disorders. CYZ is one of the leaders in the development of Biology AI 3.0 in Nanjing • Prof. Antonio Vidal-Puig visits Nanjing University at least twice a year and gives lectures. • A joint workshop on metabolic diseases is to be held in May of 2019 in Nanjing. Six scientists including Prof. Antonio Vidal-Puig from Cambridge and 15 scientists from Nanjing University will attend this workshop.Nanjing, China. 19th-25th May 2019. The Sino-UK Cardiovascular disease symposium. Cambridge, United Kingdom. 5th July 2019 Joint work shop by Cambridge University Nanjing Centre of Technology and Innovation, Institute Metabolic Science, University of Cambridge, Model Animals Research Centre (MARC), University of Nanjing. Huang-Doran I, Zhang CY, Vidal-Puig A. Extracellular Vesicles: Novel Mediators of Cell Communication In Metabolic Disease. Trends Endocrinol Metab. 2017 Jan;28(1):3-18. doi: 10.1016/j.tem.2016.10.003. Epub 2016 Oct 31. PMID: 27810172 Review. 2 Cite Share Li J, Zhang Y, Ye Y, Li D, Liu Y, Lee E, Zhang M, Dai X, Zhang X, Wang S, Zhang J, Jia W, Zen K, Vidal-Puig A, Jiang X, Zhang CY. Pancreatic ß cells control glucose homeostasis via the secretion of exosomal miR-29 family.J Extracell Vesicles. 2021 Jan;10(3):e12055. doi: 10.1002/jev2.12055. Epub 2021 Jan 21. PMID: 33520119 Free PMC article. |
| Start Year | 2018 |
| Description | NANJING/SUZHOU |
| Organisation | Nanjing University (NJU) |
| Country | China |
| Sector | Academic/University |
| PI Contribution | Provide expertise in murine metabolic phenotyping |
| Collaborator Contribution | Phenotyping of mice and PhD studentship |
| Impact | N/A • Prof. Antonio Vidal-Puig is a concurrent professor at Nanjing University appointed in September of 2017. • A joint lab focusing on non-alcoholic fatty liver disease has been established at MARC in 2017, co-headed by Profs. Antonio Vidal-Puig and Shuai Chen. • Strong collaborative links with professor Chen Yu Zhang at the Institute of Life Sciences of the University of Nanjing to identify mechanism of disease in metabolic disorders. CYZ is one of the leaders in the development of Biology AI 3.0 in Nanjing • Prof. Antonio Vidal-Puig visits Nanjing University at least twice a year and gives lectures. • A joint workshop on metabolic diseases is to be held in May of 2019 in Nanjing. Six scientists including Prof. Antonio Vidal-Puig from Cambridge and 15 scientists from Nanjing University will attend this workshop.Nanjing, China. 19th-25th May 2019. The Sino-UK Cardiovascular disease symposium. Cambridge, United Kingdom. 5th July 2019 Joint work shop by Cambridge University Nanjing Centre of Technology and Innovation, Institute Metabolic Science, University of Cambridge, Model Animals Research Centre (MARC), University of Nanjing. Huang-Doran I, Zhang CY, Vidal-Puig A. Extracellular Vesicles: Novel Mediators of Cell Communication In Metabolic Disease. Trends Endocrinol Metab. 2017 Jan;28(1):3-18. doi: 10.1016/j.tem.2016.10.003. Epub 2016 Oct 31. PMID: 27810172 Review. 2 Cite Share Li J, Zhang Y, Ye Y, Li D, Liu Y, Lee E, Zhang M, Dai X, Zhang X, Wang S, Zhang J, Jia W, Zen K, Vidal-Puig A, Jiang X, Zhang CY. Pancreatic ß cells control glucose homeostasis via the secretion of exosomal miR-29 family.J Extracell Vesicles. 2021 Jan;10(3):e12055. doi: 10.1002/jev2.12055. Epub 2021 Jan 21. PMID: 33520119 Free PMC article. |
| Start Year | 2018 |
| Description | New Tissue Culture system |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Establishment of a physiological culture system to improve translation in metabolic research |
| Collaborator Contribution | Daniel Fazakerley: Expertise in signalling Sam virtue: Expertise in Tissue culture Christian Frezza: Expertise in Metabolomics Research Interests |
| Impact | This is a multi collaborative collaboration to improve tissue culture and contributes to 3R |
| Start Year | 2021 |
| Description | SF, GPCR biology |
| Organisation | University of Montreal |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | identifying human variants in MC4R associated with obesity and creating constructs to characterise the effects of human mutations in trafficking |
| Collaborator Contribution | characterise the effects of human mutations in trafficking |
| Impact | manuscript being prepared for submission |
| Start Year | 2018 |
| Description | Ulster, transgenic mice |
| Organisation | Ulster University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration involving transgenic mouse models generated in Cambridge, and shipped to Ulster |
| Collaborator Contribution | Collaborators will work with the transgenic model |
| Impact | None to date |
| Start Year | 2016 |
| Description | Yuki Oka |
| Organisation | California Institute of Technology |
| Department | Division of Biology and Biological Engineering (BBE) |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Provision of mouse models |
| Collaborator Contribution | Research contribution |
| Impact | Nature publication |
| Start Year | 2017 |
| Description | 3x work experience students |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | 3 year 9 students from local schools each spent 1 week at the institute, shadowing scientists and other staff to gain understanding of lab work and the scientific process and various career options related to scientific research. |
| Year(s) Of Engagement Activity | 2019 |
| Description | 4. Bradford, UK. 1st December 2018. SRUK Seminar (Society of Spanish Researchers in the UK). |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | 4. Bradford, UK. 1st December 2018. SRUK Seminar (Society of Spanish Researchers in the UK). |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.eventbrite.co.uk/e/v-christmas-seminar-science-of-healthy-diet-sports-wellbeing-tickets-... |
| Description | 5. London, UK. 30th October 2018. California Walnut Commission Scientific & Health Research Meeting. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 5. London, UK. 30th October 2018. California Walnut Commission Scientific & Health Research Meeting. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.bighospitality.co.uk/News/Promotional-Features/California-Walnut-Culinary-Institute-of-A... |
| Description | 6. Sheffield, UK. 10th-11th September 2018. The British Society for Cardiovascular Research Autumn Meeting 'Inflammation and repair'. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | 6. Sheffield, UK. 10th-11th September 2018. The British Society for Cardiovascular Research Autumn Meeting 'Inflammation and repair'. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://bscr.org/event/bscr-autumn-meeting-2018-inflammation-and-repair/ |
| Description | Are your genes to blame when your jeans don't fit? For Cam Alumni Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Giles Yeo gave this talk to around 250 university alumni and members of the public |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://sms.cam.ac.uk/collection/2851871 |
| Description | BAT in Granada |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Interested in Brown Adipose Tissue? Can't miss this Symposium! https://finut-en.congressus.es/symposiumbat/index @ibsGRANADA @CIBER_OBN @TVPLab @FIBAO @CanalUGR @finutibero |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://twitter.com/ruizruizjonatan/status/1024216467729010688?s=12 |
| Description | Basel, Switzerland. 11th-14th September 2018. EMBO at Basel Life. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 2. Basel, Switzerland. 11th-14th September 2018. EMBO at Basel Life. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.basellife.org/basel-life-2018.html |
| Description | Bilbao, Spain. 8th June 2018. Seminar at Biogune. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 7. Bilbao, Spain. 8th June 2018. Seminar at Biogune. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://twitter.com/CICbioGUNE |
| Description | Boston, USA. 11th May 2018. "Adventures in Metabolism" Symposium at Harvard Medical School. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Boston, USA. 11th May 2018. "Adventures in Metabolism" Symposium at Harvard Medical School. Lecture related to the role of Brown fat in metabolism. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.evensi.us/adventures-metabolism-symposium-celebrate-jeffrey-flier-70th-birthday/25406324... |
| Description | CAA Incretin 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Oral presentation. Networking |
| Year(s) Of Engagement Activity | 2022 |
| Description | CM, Association of Clinical Biochemistry NICE guideline advisory group |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | aimed to increase awareness of the need for appropriate biochemistry input into clinical care guidelines |
| Year(s) Of Engagement Activity | 2018 |
| Description | CM, Association of Clinical Pathologists Vice chair biochemistry panel |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Encouraged increased biochemistry input into curricula |
| Year(s) Of Engagement Activity | 2018 |
| Description | CM, Experiences of a chief investigator in CRN Eastern |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | presentation +Q&A session at regional meeting |
| Year(s) Of Engagement Activity | 2018 |
| Description | CM, Gestational diabetes - update at CRN Eastern Reproductive Health symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Increase awareness of clinical studies in reproductive health and metabolism |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cambridge Big Biology Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | participated in the 2019 Cambridge Big Biology Day at hills Rd 6th Form College. Ran hands on events based on unit research areas. Also advised student on career choices related to life science |
| Year(s) Of Engagement Activity | 2019 |
| Description | Cambridge University in Nanjing. Cambridge UNiversity Anjing Centre for innovation and technology |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Cambridge University in Nanjing. At the entrance of the Cambridge University Nanjing Centre of Technology and Innovation, with my colleague from Cambridge Prof Daping Chu, the Director of the Centre |
| Year(s) Of Engagement Activity | 2018 |
| Description | Careers Fair |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Deborah Goldspink attended the North Norfolk School Federation Careers Fair to talk to year 6 pupils about careers in science |
| Year(s) Of Engagement Activity | 2019 |
| Description | Contribution to 100 Kilo Kids, Channel 4 |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Prof Sadaf Farooqi was filmed talking to a mother and daughter in the Institute's Translational Research Facility for this Channel 4 documentary |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.youtube.com/watch?v=N-ciIB9-4KM&t=2s |
| Description | Contribution to Genomics England video |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Prof Krishna Chatterjee contributed to a film, partly made int he Institute, by Genomics England as part of a series on the 100K Genomes Project. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.youtube.com/watch?v=OONvM0CX03I |
| Description | Contribution to Operation Ouch, Food, poo and you |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | IMS-MRL PhD student Jennie Leggat was filmed speaking to presenter Chris Van Tulleken in the Institute for this CBBC programme. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.bbc.co.uk/iplayer/episode/m000cgln/operation-ouch-series-8-15-food-poo-and-you |
| Description | DS, Helmholtz Diabetes meeting, invited speaker |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | invited speaker at prestigious international conference |
| Year(s) Of Engagement Activity | 2019 |
| Description | DS, Keystone presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | invited speaker at influential scientific meeting |
| Year(s) Of Engagement Activity | 2019 |
| Description | DS, NHS England review of Severe Insulin Resistance Service |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | VISIT BY POLYCYMAKERS TO secure ongoing support for specialist clinic |
| Year(s) Of Engagement Activity | 2019 |
| Description | Davidson Nichol film for black History Month |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | IMS-MRL PhD student Tendai Chisowa made this film as part of the Cambridge University Black History Month activities |
| Year(s) Of Engagement Activity | 2018 |
| Description | Doha, Qatar. 4th-6th December 2019 Anti-Doping Laboratory Qatar for the 7th Junior Symposium |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | This activity was related to a PhD annual conference ree=lated to the course for women in Qatar as part of the programme coordinated by Univeristy College of London, Bristol and Groningen. |
| Year(s) Of Engagement Activity | 2019 |
| Description | EPOS2019 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Wehosted the 2020 Horizon EPoS project Steering commitee meeting at St Catherine College in Cambridge to discuss the latest results on the pathogenesis, diagnostic and treatment of fatty liver and NASH. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.linkedin.com/in/toni-vidal-puig-md-phd-frcp-fmedsci-emba-43804113/detail/recent-activity... |
| Description | ER appeared on Countryfile Diaries |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | In May 2019, Eleanor Raffan spoke to Countryfile Diaries reporters about her obesity research with labrador dogs. |
| Year(s) Of Engagement Activity | 2019 |
| Description | ER, BBC Futures article |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A widely read 'long read' article on BBC Futures which sparked interest in how our and other work studying pets and production animals can inform the science of the human obesity epidemic. |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.bbc.com/future/story/20190109-what-we-can-learn-from-overweight-pets-about-human-obesity |
| Description | ER, Engagement with GOdogs study participants |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | 800 dog owning members of the public have signed up to participate in our study and receive quarterly electronic newsletters detailing our findings and updates on new canine science. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.GOdogs.org.uk |
| Description | ER, Talk on obesity genetics to Kennel Club breeders' forum |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presenting our work on the genetics of obesity in dogs to Breed Health Coordinators at a Kennel Club Forum; attendees were particularly interested in how studying dogs can inform human focussed research. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.thekennelclub.org.uk/events/ |
| Description | EU Science event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | took part in an EU H2020-funded event at Ely Cathedral. Ran several activities based on unit research. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Eclip Lipodystrophy Annual Meeting (DS) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Host annual European Consortium for Lipodystrophy (Eclip) meeting in Cambridge |
| Year(s) Of Engagement Activity | 2021 |
| URL | http://www.aelip.co.uk/european-consortium-of-lipodystrophies-eclip.asp#:~:text=European%20Consortiu... |
| Description | FM, Primary school outreach activity |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Visit to a local elementary school to discuss the neuroscience of hunger |
| Year(s) Of Engagement Activity | 2019 |
| Description | FM, hosted student in the laboratory |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | the individual who visited the laboratory gained appreciation of a career in biology |
| Year(s) Of Engagement Activity | 2019 |
| Description | Farooqi group Cell paper press activity |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Press activity around the Cell paper Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity (Sadaf Farooqi corresponding author) received substantial coverage in National press (6 UK papers, at least 4 International) plus 11 pieces in popular science/health press |
| Year(s) Of Engagement Activity | 2019 |
| Description | GPR. Cambridge UGI cancer symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | "The post-gastrectomy patient, metabolic considerations" |
| Year(s) Of Engagement Activity | 2018 |
| Description | Girlguiding Norfolk STEM event |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other audiences |
| Results and Impact | PhD student Rachel Foreman gave a talk about her research and career in science to Girl Guides as part of a bigger county-wide event in Norwich |
| Year(s) Of Engagement Activity | 2019 |
| Description | Gothenburg, Sweden. 5th October 2018. Wallenberg Lab 30th Anniversary Symposium. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Gothenburg, Sweden. 5th October 2018. Wallenberg Lab 30th Anniversary Symposium. |
| Year(s) Of Engagement Activity | 2018 |
| Description | ITV short film on genetics of thinness |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Sadaf Farooqi took part in a short film, made partly at the Institute, for ITV News. The topic was based around her recent paper Genetic architecture of human thinness compared to severe obesity (PLOS Genetics, Jan 2019) |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.itv.com/news/2019-01-24/thin-people-its-down-to-your-genes-not-because-youre-morally-sup... |
| Description | Inspirational Scientists |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Post doc Sam Virtue made 2 films with Cambridge University Press in their Inspirational Scientists YouTube series. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.youtube.com/playlist?list=PL2HgNIO5uPKBNLLCY9lhV8HwUY3OOMeq2 |
| Description | Interview on BBC Radio 4's Life Scientific |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interviewed by Jim Al-Khalili about the powerful influence our genes have on how we put on weight, and why many of us struggle to lose it. This sparked a big response, including being contacted by Cambridge MP and shadow food minister Daniel Zeichner. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.bbc.co.uk/programmes/m000rmp5 |
| Description | Invited Symposium Speaker, British Endocrine Society Annual Meeting, Edinburgh, Scotland November 8, 2021. Title 'Single-cell analysis and heterogeneity of hypothalamic neurons' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Symposium Speaker, British Endocrine Society Annual Meeting, Edinburgh, Scotland November 8, 2021. Title 'Single-cell analysis and heterogeneity of hypothalamic neurons' |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited Symposium Speaker, German Diabetes Association Annual Meeting May 14, 2021. Title 'Heterogeneity of hypothalamic POMC neurons' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Symposium Speaker, German Diabetes Association Annual Meeting May 14, 2021. Title 'Heterogeneity of hypothalamic POMC neurons' |
| Year(s) Of Engagement Activity | 2021 |
| Description | Is obesity a choice talk at Cam Big Biology Day 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Giles Yeo gave this talk at the Cambridge Hills Road Sixth Form College as part of the annual Big Biology Day event in Cambridge - mostly aimed at older children and teens thinking about a future career |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.hillsroad.ac.uk/about-us/news-and-events/2019/09/27/big-biology-day#:~:text=Saturday%205... |
| Description | London International Youth Science Forum visit |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | 8 six formers came to the IMS-MRL for a lab tour and careers Q+A. Hosted by 6 staff/graduate students |
| Year(s) Of Engagement Activity | 2019 |
| Description | ME radio interview |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | In October 2020, Mark Evans spoke on the Phil Williams show on Times Radio about glucose sensors and diabetes. |
| Year(s) Of Engagement Activity | 2020 |
| Description | MIddle EaSt obesity |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Professors Toni Vidal-Puig MD PhD FRCP FMedSci EMBA and Meis Moukayed have honoured us by writing the fascinating article, People with obesity: Their heroic battle to defeat their genes in a hostile hypercaloric sedentary environment. The professors explain why more than 50 human genes, the environment and lifestyle culture all contribute to why it is not so easy as the doctor telling the patient to lose weight. In addition to looking at the 'why' of obesity, |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.middleeastmedicalportal.com/product/november-december-2018/ |
| Description | MRC Festival Science Bus |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | IMS staff and students worked with a local secondary school teacher and a communications trainer to develop 1 existing and 2 new activities for use with Year 9 pupils. We ran a whole day of activities on a bus with each of 2 schools considered to have 'under-served' intake - North Cambridge Academy and Ely College - meeting the complete Year groups in each case. We reached over 300 teenagers with the activities. Feedback from our researcher volunteers: - [Teachers] were also very complimentary and engaged with our activity as it touched on their lessons or personal lives - I was surprised at just how smoothly it went, and by how engaged the pupils were Several teachers commented that they really liked the fact that we had three different activities that looked at different areas of research, but also themselves appealed to different personalities - I was surprised how children very suddenly came up with very interesting and smart questionsit definitely makes you think about the scientific content in a different way! - I learnt that secondary school children are being taught more complex science than I expected Post-event responses from 62 year 9 pupils at North Cambridge Academy showed that - 87% learned something new - 79% did not have any relative or friend who worked in science or for a university - just 11% (7 students) remembered ever going to the Cambridge Science Festival. - 25% said that after the session they were more likely to consider a career in science. Feedback on leaving the Institute from a staff member involved in development and delivery of this activity: - Taking part in PE helped me to decide about the job change. I got the new job partly because of the skills and experience from being involved |
| Year(s) Of Engagement Activity | 2019 |
| Description | Madrid, Spain. 22nd November 2018. CIBEROBN Annual Symposium. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Madrid, Spain. 22nd November 2018. CIBEROBN Annual Symposium. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.ciberobn.es/en |
| Description | Meet the Scientist |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Five members of IMS-MRL staff held short 1:1 or small group meetings with members of the public over 2 days as part of the Cambridge Science Festival |
| Year(s) Of Engagement Activity | 2018 |
| Description | Meet the Scientists 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Two members of IMS-MRL staff met members of the public attending Cambridge Science Festival events for short 1:1 or small group conversations |
| Year(s) Of Engagement Activity | 2019 |
| Description | Mexico Instituto Zubiran de Nutricion |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Supporters |
| Results and Impact | Seminar evaluation PhD students projects |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.linkedin.com/in/toni-vidal-puig-md-phd-frcp-fmedsci-emba-43804113/detail/recent-activity... |
| Description | NCA work experience interviews |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | In January 2020 3 year 10 pupils from North Cambridge Academy visited the IMS-MRL to see the labs and to be interviewed for summer work experience placements. Unfortunately these were unable to progress due to the COVID pandemic |
| Year(s) Of Engagement Activity | 2020 |
| Description | NCA work experience students |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Two Year 10 work experience students spent a week at the IMS-MRL. The students were from North Cambridge Academy, the 'under-served intake' school we started workign with this year. Ten of our staff and students were involved in hosting them. |
| Year(s) Of Engagement Activity | 2019 |
| Description | NS, British Endocrine Society invited lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | A clinical presentation on central hypothyroidism attended by clinical thyroidologists |
| Year(s) Of Engagement Activity | 2018 |
| Description | NS, British thyroid association research presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | 75 thyroidologists attended a research presentation which sparked discussion and further collaborations |
| Year(s) Of Engagement Activity | 2018 |
| Description | NS, European thyroid association research presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Thyroidologists attended a late breaking research presentation which sparked discussion and further collaborations |
| Year(s) Of Engagement Activity | 2018 |
| Description | NS, European thyroid association research presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Thyroidologists attended a research presentation which sparked discussion |
| Year(s) Of Engagement Activity | 2018 |
| Description | NS. European thyroid association invited lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | thyroidologists attended an invited lecture on whole exome sequencing which sparked discussion about uses and interpretation of this technology |
| Year(s) Of Engagement Activity | 2018 |
| Description | Naples, Italy. 28th May 2018. Seminar at The Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" of the National Research Council (CNR). |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Naples, Italy. 28th May 2018. Seminar at The Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" of the National Research Council (CNR). Lecture on the Adipose tissue expandability, lipotoxicity and metabolic syndrome. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Neuronal Control of Metabolism symposium, 12th February 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | outline of role of GDF15 in control of food intake and how this knowledge may affect drug design in the future |
| Year(s) Of Engagement Activity | 2020 |
| Description | Paris, France. 11th-15th April 2018. EASL International Liver Congress. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at the Paris, France. 11th-15th April 2018. EASL International Liver Congress focused on the pathogenesis of fatty liver and the effect of Lipotoxicty |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://easl.eu/discover/events/detail/2018/the-international-liver-congress-2018 |
| Description | Pint of Science: how to communicate science |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk given by Giles Yeo |
| Year(s) Of Engagement Activity | 2018 |
| Description | Public stand at LifeLab |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | 4 IMS staff/ graduate students ran a stand at Ely Cathedral as part of the Cambridge LifeLab events for European Researchers' Night. We ran our Labrador Laboratory activity. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.camlifelab.co.uk/ely |
| Description | Public web section |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | We launched a new public-facing section to our website in summer 2020. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.mrl.ims.cam.ac.uk/find-out-more-2/ |
| Description | RAREfest 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Giles Yeo gave a talk and Claire Adams gave a poster at this event run by Cambridge Rare Disease Network that had national reach and over 900 participants. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.camraredisease.org/rarefest-review/ |
| Description | RAREfest stand |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | In December 2020 we contributed a virtual stand to RAREfest 2020, a biennial event for a broad audience. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.camraredisease.org/rarefest20/ |
| Description | RSPCA AWERB Lay Members' Forum |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | In December 2019 Tiny Coll gave a talk to the RSPCA AWERB Lay Members' Forum on the ethics of animal research |
| Year(s) Of Engagement Activity | 2019 |
| Description | SF, genetics of thinness |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A press release related to a research publication concerning the genetics of thinness resulted in numerous TV, radio and newspaper articles at national and international level. press conference or response to a media enquiry/interview. Media coverage was used as a platform to start a widespread discussion around the genetic basis of thinness and, through this, a discussion into the genetic contribution to obesity |
| Year(s) Of Engagement Activity | 2018 |
| Description | Science News Study inMice suggests drug to turn fat brown could help fight obesity |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | https://www.sciencedaily.com/releases/2018/11/181126123416.htm Study in mice suggests drug to turn fat 'brown' could help fight obesity Date:November 26, 2018 Source:University of Cambridge Summary:Our bodies contain two types of fat: white fat and brown fat. While white fat stores calories, brown fat burns energy and could help us lose weight. Now, scientists have found a way of making the white fat 'browner' and increasing the efficiency of brown fat. While their study was carried out in mice, they hope that this finding will translate into humans and provide a potential new drug to help fight obesity. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.sciencedaily.com/releases/2018/11/181126123416.htm |
| Description | Singapore2019 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | University of Cambridge meets with our colleagues from the National University of Singapore to strenght our collaborative cardiovascular research network. |
| Year(s) Of Engagement Activity | 2019 |
| Description | TEDx Cambridge YouTube - Starch, milk and alcohol |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Uploaded to ted.com as well as YouTube |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.youtube.com/watch?v=RgClxvQeXc0 |
| Description | TEDx talk -Starch, milk and alcohol |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Giles Yeo gave this talk as part of the Cambridge TEDx series to an audience of about 100. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Taking part in the artificial pancreas study |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | Janet Allen and Gianluca Musolino took part in this video about a child study participant as part for the NIHR Innovative technology series |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.youtube.com/watch?v=d2CHRlBcFAo |
| Description | The artificial pancreas |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Roman Hovorka made this video with NIHR to explain the artificial pancreas and how it was developed |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.youtube.com/watch?v=CsUmyA0z6vA |
| Description | The truth about diets for Cam Sci Fest 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Public talk given by Giles Yeo as part of the Cambridge Science Festival |
| Year(s) Of Engagement Activity | 2019 |
| Description | Tye 2 Diabetes; Atherapeutic avenue is emerging |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Date:December 5, 2018 Source:INSERM (Institut national de la santé et de la recherche médicale) Summary:Restoring the action of insulin is one of the keys to fighting type 2 diabetes. Researchers are developing a therapeutic strategy that uses the properties of an enzyme (hormone-sensitive lipase) which, when stimulating fatty-acid synthesis in the fat cells, has a beneficial effect on insulin action. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.sciencedaily.com/releases/2018/12/181205134014.htm |
| Description | University of Toronto, City-wide Grand Rounds April 23, 2021. Title 'The brain control of food intake: Can an old dog teach us new tricks?' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | University of Toronto, City-wide Grand Rounds April 23, 2021. Title 'The brain control of food intake: Can an old dog teach us new tricks?' |
| Year(s) Of Engagement Activity | 2021 |
| Description | What does it matter? |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | In August 2019, Sue Ozanne was one of 4 experts on a panel discussion on food and health organised by BBSRC DTP PhD students. The discussion was preceded by a public film screening. |
| Year(s) Of Engagement Activity | 2019 |
| Description | World Forum on Scientific & Technological Innovation in London. Looking for solutions to the emerging epidemic of ageing related health problems in China |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Highlights from the World Forum on Scientific & Technological Innovation in London. Looking for solutions to the emerging epidemic of ageing related health problems in China |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.linkedin.com/in/toni-vidal-puig-md-phd-frcp-fmedsci-emba-43804113/detail/recent-activity... |
| Description | brownies, 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | took activities based on unit research to a local brownie group. activities demonstrated by postdocs and PhD students |
| Year(s) Of Engagement Activity | 2019 |
| Description | bury st edmunds sci fest |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | ran activities and events based on unit research at the Bury St Edmunds Science Festival |
| Year(s) Of Engagement Activity | 2020 |
| Description | cambridge science festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | participation in Cambridge science festival family weekend events in central Cambridge and on the Addenbrookes campus (3 days in total). events aimed at 8-15 year olds. |
| Year(s) Of Engagement Activity | 2019 |
| Description | fm, Participant in Neurodegeneration Challenge Network |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | As a award recipient, I interacted with about 150 students, postdocs, clinicians, funders, and patients interested in new paradigms in neurodegenerative disease research and open science. |
| Year(s) Of Engagement Activity | 2019 |
| Description | fm, Participant in New York Stem Cell Investigator Programme |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | As a award recipient, I interacted with about 150 students, postdocs, clinicians, funders, and patients interested in new paradigms in neurodegenerative disease research and open science. |
| Year(s) Of Engagement Activity | 2019 |
| Description | https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283 |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283 November 27, 2018 Could this be a solution for the obesity crisis? Samuel Virtue, University of Cambridge; Antonio Vidal-Puig, University of Cambridge, and Vanessa Pellegrinelli, University of Cambridge Scientists manage to boost brown fat in mice with a molecule called BMP8b. Could this be the future for treating obesity? |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283 |
| Description | ims schools visit |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | two full day visits to a local school with activities based on unit research designed for year 9 pupils. Students and postdocs volunteered to lead the activities. |
| Year(s) Of Engagement Activity | 2019 |
| Description | innvited talk to Diabetes UK annual professional conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | able to share our data with colleagues and clinicians from across the UK |
| Year(s) Of Engagement Activity | 2019 |
| Description | presentation to a primary school (FM) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | FM gave a talk about the brain and the neuroscience of appetite regulation at a local primary school to all grade levels (approximately 210 students). This sparked over 1 hour of questions and the school reported increased interest in the brain and many questions in class in this area. |
| Year(s) Of Engagement Activity | 2019 |
| Description | seminar to Institute of Metabolic Science in Aberdeen |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | engaged with scientists in another centre of metabolic excellence to share ideas around common research interests |
| Year(s) Of Engagement Activity | 2018 |
| Description | two iBiology talks filmed |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Prof Stephen O'Rahilly filmed 2 talks on obesity (causes and consequences) for the iBiology series (116K subscribers) |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.ibiology.org/human-disease/obesity/ |
| Description | visit from Jersey school students |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | hosted a 1-day visit from students and teachers from a school in Jersey. students and teachers attended lectures and spent time with our PhD students to learn about life as a PhD student in Cambridge |
| Year(s) Of Engagement Activity | 2020 |
| Description | Örebro/Sweden. 26th-28th August 2018. Nordic Metabolomics Conference. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Örebro/Sweden. 26th-28th August 2018. Nordic Metabolomics Conference. Role of lipidomics in metabolic research Opening keynote lecture Antonio Vidal-Puig (University of Cambridge, UK) "Adipose tissue expandability, lipotoxicity and the metabolic syndrome" |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.oru.se/english/about-us/conferences/nordic-metabolomics-conference/program/ |