Cohorts and data collection
Lead Research Organisation:
University College London
Department Name: UNLISTED
Abstract
Our work requires substantial data collection from our population cohorts, and putting structures in place to check, take care of and share data in a secure way with other scientific researchers. Our core cohort is the MRC National Survey of Health and Development, (1946 UK birth cohort), but we also manage other cohorts such as DELPHIC (Camden based population cohort of older people), and SABRE (a tri-ethnic London based population cohort). Our research uses these and other cohorts to answer specific scientific questions.
Technical Summary
Aim
This theme serves the underpinning cohort platforms, providing essential data for all programmes.
Research Objectives
We plan core data collection on key health and sociodemographic variables as identified in individual programmes. We build on the strengths of the well-established core funded MRC National Survey of Health and Development (NSHD) and will capitalise on linkages with the WT funded Delirium and Population Health Informatics Cohort (DELPHIC) cohort. Investigators within the Unit also lead the Southall and Brent REvisited (SABRE) tri-ethnic older age cohort which has complementary data of relevance to some programmes.
Methods
The Cohorts and Data Collection theme has two sub-themes; the first is Data Collection, concerned with de novo clinical, home visit and questionnaire data capture for the current QQ, and the second is Cohort Maintenance, which is concerned with data and sample curation, linkages, and overall Unit management.
Translational aspects, and public health exploitation are detailed in individual programmes.
This theme serves the underpinning cohort platforms, providing essential data for all programmes.
Research Objectives
We plan core data collection on key health and sociodemographic variables as identified in individual programmes. We build on the strengths of the well-established core funded MRC National Survey of Health and Development (NSHD) and will capitalise on linkages with the WT funded Delirium and Population Health Informatics Cohort (DELPHIC) cohort. Investigators within the Unit also lead the Southall and Brent REvisited (SABRE) tri-ethnic older age cohort which has complementary data of relevance to some programmes.
Methods
The Cohorts and Data Collection theme has two sub-themes; the first is Data Collection, concerned with de novo clinical, home visit and questionnaire data capture for the current QQ, and the second is Cohort Maintenance, which is concerned with data and sample curation, linkages, and overall Unit management.
Translational aspects, and public health exploitation are detailed in individual programmes.
Organisations
- University College London (Lead Research Organisation)
- University College London (Collaboration)
- UNIVERSITY OF LEICESTER (Collaboration)
- IMPERIAL COLLEGE LONDON (Collaboration)
- BRADFORD TEACHING HOSPITALS NHS FOUNDATION TRUST (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
- National Institute for Health and Care Excellence (NICE) (Collaboration)
- UNIVERSITY OF OXFORD (Collaboration)
- University of the West of England (Collaboration)
- UNIVERSITY OF GLASGOW (Collaboration)
- London School of Hygiene and Tropical Medicine (LSHTM) (Collaboration)
- UNIVERSITY OF EDINBURGH (Collaboration)
- UNIVERSITY OF YORK (Collaboration)
- SWANSEA UNIVERSITY (Collaboration)
- UNIVERSITY OF LIVERPOOL (Collaboration)
- University of Bristol (Collaboration)
- UNIVERSITY OF SOUTHAMPTON (Collaboration)
- KING'S COLLEGE LONDON (Collaboration)
People |
ORCID iD |
Publications
Al Saikhan L
(2021)
Corrigendum: Imaging Protocol, Feasibility, and Reproducibility of Cardiovascular Phenotyping in a Large Tri-Ethnic Population-Based Study of Older People: The Southall and Brent Revisited (SABRE) Study.
in Frontiers in cardiovascular medicine
Al Saikhan L
(2022)
Relationship Between Image Quality and Bias in 3D Echocardiographic Measures: Data From the SABRE (Southall and Brent Revisited) Study.
in Journal of the American Heart Association
Al Saikhan L
(2020)
Imaging Protocol, Feasibility, and Reproducibility of Cardiovascular Phenotyping in a Large Tri-Ethnic Population-Based Study of Older People: The Southall and Brent Revisited (SABRE) Study.
in Frontiers in cardiovascular medicine
Almeida-Meza P
(2022)
Moderating Role of Cognitive Reserve Markers Between Childhood Cognition and Cognitive Aging: Evidence From the 1946 British Birth Cohort.
in Neurology
Bann D
(2021)
Changes in the behavioural determinants of health during the COVID-19 pandemic: gender, socioeconomic and ethnic inequalities in five British cohort studies.
in Journal of epidemiology and community health
Bann D
(2022)
Polygenic and socioeconomic risk for high body mass index: 69 years of follow-up across life.
in PLoS genetics
Bauermeister S
(2020)
The Dementias Platform UK (DPUK) Data Portal.
in European journal of epidemiology
Bell G
(2022)
Positive psychological constructs and cognitive function: A systematic review and meta-analysis
in Ageing Research Reviews
Blodgett J
(2023)
Prognostic accuracy of the one-legged balance test in predicting falls: 15-years of midlife follow-up in a British birth cohort study
in Frontiers in Sports and Active Living
Blodgett JM
(2021)
Bidirectional associations between word memory and one-legged balance performance in mid and later life.
in Experimental gerontology
Blodgett JM
(2022)
Associations of Word Memory, Verbal Fluency, Processing Speed, and Crystallized Cognitive Ability With One-Legged Balance Performance in Mid- and Later Life.
in The journals of gerontology. Series A, Biological sciences and medical sciences
Blodgett JM
(2022)
One-Legged Balance Performance and Fall Risk in Mid and Later Life: Longitudinal Evidence From a British Birth Cohort.
in American journal of preventive medicine
Blodgett JM
(2020)
Associations Between Factors Across Life and One-Legged Balance Performance in Mid and Later Life: Evidence From a British Birth Cohort Study.
in Frontiers in sports and active living
Blodgett JM
(2022)
A systematic review of one-legged balance performance and falls risk in community-dwelling adults.
in Ageing research reviews
Bridger Staatz C
(2019)
Number of children and body composition in later life among men and women: Results from a British birth cohort study.
in PloS one
Captur G
(2022)
Plasma proteomic signature predicts who will get persistent symptoms following SARS-CoV-2 infection.
in EBioMedicine
Chandrasekar R
(2023)
Adverse childhood experiences and the development of multimorbidity across adulthood-a national 70-year cohort study
in Age and Ageing
Chitalu P
(2022)
Life-space, frailty, and health-related quality of life.
in BMC geriatrics
Christiansen C
(2021)
Novel DNA methylation signatures of tobacco smoking with trans-ethnic effects.
in Clinical epigenetics
Dale C
(2023)
The impact of the COVID-19 pandemic on cardiovascular disease prevention and management
in Nature Medicine
Eastwood SV
(2021)
Ethnic differences in guideline-indicated statin initiation for people with type 2 diabetes in UK primary care, 2006-2019: A cohort study.
in PLoS medicine
El Baou C
(2023)
Psychological therapies for depression and cardiovascular risk: evidence from national healthcare records in England
in European Heart Journal
Fatih N
(2022)
Sex-related differences in whole brain volumes at age 70 in association with hyperglycemia during adult life.
in Neurobiology of aging
George A
(2021)
Life course socioeconomic position and DNA methylation age acceleration in mid-life.
in Journal of epidemiology and community health
Ghezzi ES
(2022)
How do predisposing factors differ between delirium motor subtypes? A systematic review and meta-analysis.
in Age and ageing
Gondek D
(2022)
Psychological distress from early adulthood to early old age: evidence from the 1946, 1958 and 1970 British birth cohorts.
in Psychological medicine
González-Viveros N
(2022)
Quantification of glycated hemoglobin and glucose in vivo using Raman spectroscopy and artificial neural networks.
in Lasers in medical science
Green R
(2022)
Metabolic correlates of late midlife cognitive outcomes: findings from the 1946 British Birth Cohort.
in Brain communications
Green RE
(2023)
Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer's disease.
in Alzheimer's research & therapy
Hao M
(2023)
Using Physiological System Networks to Elaborate Resilience Across Frailty States
in The Journals of Gerontology: Series A
Hostettler I
(2019)
C9orf72 and intracerebral hemorrhage
in Neurobiology of Aging
Jacques Wels
(2022)
Mental and social wellbeing and the UK coronavirus job retention scheme: Evidence from nine longitudinal studies.
in Social science & medicine (1982)
James S
(2023)
Adulthood cognitive trajectories over 26 years and brain health at 70 years of age: findings from the 1946 British Birth Cohort
in Neurobiology of Aging
James SN
(2023)
Timing of physical activity across adulthood on later-life cognition: 30 years follow-up in the 1946 British birth cohort.
in Journal of neurology, neurosurgery, and psychiatry
John A
(2022)
Salivary cortisol in longitudinal associations between affective symptoms and midlife cognitive function: A British birth cohort study.
in Journal of psychiatric research
Jones S
(2020)
Cohort Profile Update: Southall and Brent Revisited (SABRE) study: a UK population-based comparison of cardiovascular disease and diabetes in people of European, South Asian and African Caribbean heritage.
in International journal of epidemiology
Jones S
(2022)
Antihypertensive treatment effect on exercise blood pressure and exercise capacity in older adults.
in Journal of hypertension
Kanoni S
(2022)
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
in Genome biology
Keshavan A
(2021)
Population-based blood screening for preclinical Alzheimer's disease in a British birth cohort at age 70.
in Brain : a journal of neurology
Khanolkar AR
(2023)
Ethnic and Sexual Identity-Related Inequalities in Adolescent Health and Well-Being in a National Population-Based Study.
in LGBT health
Related Projects
| Project Reference | Relationship | Related To | Start | End | Award Value |
|---|---|---|---|---|---|
| MC_UU_00019/1 | 01/04/2019 | 31/03/2024 | £4,569,000 | ||
| MC_UU_00019/2 | Transfer | MC_UU_00019/1 | 01/04/2019 | 31/03/2024 | £1,784,000 |
| MC_UU_00019/3 | Transfer | MC_UU_00019/2 | 01/04/2019 | 31/03/2024 | £1,468,000 |
| MC_UU_00019/4 | Transfer | MC_UU_00019/3 | 01/04/2019 | 31/03/2024 | £843,000 |
| Description | British Heart Foundation's 60th Birthday Parliamentary Reception |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| URL | https://www.bhf.org.uk/what-we-do/policy-and-public-affairs/we-work-with-government |
| Description | Evidence to Science and Technology Select Committee: Ageing: Science, Technology and Healthy Living - AH |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| URL | https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&ved=2ahUKEwjN4_-R6aDvAhVvShUIHf1OBbsQ... |
| Description | Biomedical follow-up of 1958 Birth Cohort Study members at age 60 |
| Amount | £1,544,004 (GBP) |
| Funding ID | MR/P023444/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2017 |
| End | 03/2022 |
| Description | COVID-19 Longitudinal Health and Wellbeing - National Core Study (LWH-NCS) |
| Amount | £5,203,856 (GBP) |
| Funding ID | MC_PC_20030 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2020 |
| End | 03/2021 |
| Description | Characterisation, Determinants, Mechanisms And Consequences Of The Long-term Effects Of COVID-19: Providing The Evidence Base For Health Care Services |
| Amount | £9,539,110 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2021 |
| End | 02/2024 |
| Description | Cohort and Longitudinal Studies Enhancement Resources (CLOSER) |
| Amount | £9,395,000 (GBP) |
| Funding ID | ES/K000357/1 |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2012 |
| End | 03/2022 |
| Title | CLOSER online guide on dietary mesures |
| Description | New online guide on dietary measures and estimated nutrient intake within and across eight CLOSER partner studies. |
| Type Of Material | Biological samples |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | Increased awareness of these dietary measures for future use in research projects |
| URL | https://www.closer.ac.uk/cross-study-data-guides/dietary-data-guide/ |
| Title | Covid 19 questionnaire |
| Description | A covid questionnaire was developed and sent to all NSHD study members. This was an online questionnaire about what the study members' lives have been like during the pandemic. The questionnaire covered the impact of the pandemic on work, health, family and social life. Three waves have been sent out. |
| Type Of Material | Biological samples |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Too early to say |
| Title | Online COVID questionnaire |
| Description | NSHD study members were sent upto three online/postal questionnaires on COVID. In the first questionnaire, a variety of questions were asked to capture a physical and mental health and wellbeing, family and relationships, education, work, and finances during the first national lockdown. In the second questionnaire, we repeated many of the topic areas as in Wave 1, but included questions on health care, financial transfer and life events. For the third questionnaire, we additionally asked about the vaccination programme and long COVID. |
| Type Of Material | Biological samples |
| Year Produced | 2020 |
| Provided To Others? | No |
| Impact | data is currently being analysed |
| Title | 1970 British Cohort Study Response Dataset, 1970-2016 |
| Description | The 1970 British Cohort Study (BCS70) began in 1970 when data were collected about the births and families of babies born in the United Kingdom in one particular week in 1970. Since then, there have been nine further full data collection exercises in order to monitor the cohort members' health, education, social and economic circumstances. These took place when respondents were aged 5 in 1975, aged 10 in 1980, aged 16 in 1986, aged 26 in 1996, aged 30 in 1999-2000 (SN 5558), aged 34 in 2004-2005, aged 42 in 2012 and aged 46 in 2016-18. A range of sub-sample and supplementary surveys have also been conducted, and a separate dataset covering response to BCS70 over all waves is available under SN 5641, 1970 British Cohort Study Response Dataset, 1970-2012. Further information about the BCS70 and may be found on the Centre for Longitudinal Studies website. As well as BCS70, the CLS now also conducts the NCDS series. How to access genetic and/or bio-medical sample data from a range of longitudinal surveys: A useful overview of the governance routes for applying for genetic and bio-medical sample data, which are not available through the UK Data Service, can be found at Governance of data and sample access on the METADAC (Managing Ethico-social, Technical and Administrative issues in Data Access) website. The BCS70 Response Dataset contains response outcomes for all main sweeps of BCS70 (1970-2016). The fourth edition (March 2021) includes Sweep 10 outcomes and has been streamlined by removing cases which have never participated in any main sweep survey and are no longer being issued. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | https://cls.ucl.ac.uk/cls-studies/1970-british-cohort-study/ |
| URL | https://beta.ukdataservice.ac.uk/datacatalogue/doi/?id=5641#2 |
| Title | Avon Longitudinal Study of Parents and Children |
| Description | ALSPAC is a longitudinal birth cohort study which enrolled pregnant women who were resident in one of three Bristol-based health districts in the former County of Avon with an expected delivery date between 1st April 1991 and 31st December 1992. Around 14,000 pregnant women were initially recruited. Detailed information has been collected on these women, their partners and subsequent children using self-completion questionnaires, data extraction from medical notes, linkage to routine information systems and from hands-on research clinics. Additional cohorts of participants have since been enrolled in their own right including fathers, siblings, children of the children and grandparents of the children. Ethical approval for the study was obtained from the ALSPAC Ethics and Law Committee (IRB00003312) and Local Research Ethics. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2014 |
| Provided To Others? | Yes |
| Impact | http://www.bristol.ac.uk/alspac/ |
| URL | http://service.re3data.org/repository/r3d100011256 |
| Title | Born in Bradford |
| Description | Born in Bradford is one of the biggest and most important medical research studies undertaken in the UK. The project started in 2007 and is looking to answer questions about our health by tracking the lives of 13,500 babies and their families and will provide information for studies across the UK and around the world. The aim of Born in Bradford is to find out more about the causes of childhood illness by studying children from all cultures and backgrounds as their lives unfold. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | https://borninbradford.nhs.uk/ |
| URL | http://service.re3data.org/repository/r3d100011818 |
| Title | Covid 19 questionnaire dataset |
| Description | NSHD study members were sent upto three online/postal questionnaires on COVID. In the first questionnaire, a variety of questions were asked to capture a physical and mental health and wellbeing, family and relationships, education, work, and finances during the first national lockdown. In the second questionnaire, we repeated many of the topic areas as in Wave 1, but included questions on health care, financial transfer and life events. For the third questionnaire, we additionally asked about the vaccination programme and long COVID. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Too early to say - numerous publications and impacts will be produced using these data in the future |
| URL | https://beta.ukdataservice.ac.uk/datacatalogue/studies/study?id=8732 |
| Title | English Longitudinal Study of Ageing: Waves 0-9, 1998-2019 |
| Description | The English Longitudinal Study of Ageing (ELSA) is a longitudinal survey of ageing and quality of life among older people that explores the dynamic relationships between health and functioning, social networks and participation, and economic position as people plan for, move into and progress beyond retirement. The main objectives of ELSA are to: construct waves of accessible and well-documented panel data; provide these data in a convenient and timely fashion to the scientific and policy research community; describe health trajectories, disability and healthy life expectancy in a representative sample of the English population aged 50 and over; examine the relationship between economic position and health; investigate the determinants of economic position in older age; describe the timing of retirement and post-retirement labour market activity; and understand the relationships between social support, household structure and the transfer of assets. Further information may be found on the ELSA project website, the Institute for Fiscal Studies: ELSA and Natcen Social Research: ELSA web pages. Health conditions research with ELSA - June 2021 The ELSA Data team have found some issues with historical data measuring health conditions. If you are intending to do any analysis looking at the following health conditions, then please contact elsadata@natcen.ac.uk for advice on how you should approach your analysis. The affected conditions are: eye conditions (glaucoma; diabetic eye disease; macular degeneration; cataract), CVD conditions (high blood pressure; angina; heart attack; Congestive Heart Failure; heart murmur; abnormal heart rhythm; diabetes; stroke; high cholesterol; other heart trouble) and chronic health conditions (chronic lung disease; asthma; arthritis; osteoporosis; cancer; Parkinson's Disease; emotional, nervous or psychiatric problems; Alzheimer's Disease; dementia; malignant blood disorder; multiple sclerosis or motor neurone disease). How to access genetic and/or bio-medical sample data from a range of longitudinal surveys: A useful overview of the governance routes for applying for genetic and bio-medical sample data, which are not available through the UK Data Service, can be found at Governance of data and sample access on the METADAC (Managing Ethico-social, Technical and Administrative issues in Data Access) web site. Harmonised dataset: The Harmonised dataset is originally compiled in Stata, and contains extra alphabetic missing value codes. An SPSS version is also deposited, but as SPSS does not accommodate alphabetic missing value codes in numeric variables, the codes have transferred as long numeric codes. While the missing values are fully labelled, users should be aware that only the Stata alphabetic codes are described in the documentation. Users who prefer to use the Stata version will need access to Stata SE/MP software, as the file contains over 2,047 variables (the limit for the standard Stata 'Intercooled' version). ELSA COVID-19 study: A separate ad-hoc study conducted with ELSA respondents, measuring the socio-economic effects/psychological impact of the lockdown on the aged 50+ population of England, is also available under SN 8688, English Longitudinal Study of Ageing COVID-19 Study. Wave 1 was first released on 30 September 2020. Latest edition of ELSA: For the 35th edition (July 2021), mortality variables Mortstat, Yrdeath, agedead2 and maincod have been removed from the index file at the depositor's request, due to finalised agreement with NHS Digital. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | https://www.ucl.ac.uk/epidemiology-health-care/research/behavioural-science-and-health/research/psychobiology/english-longitudinal-study-ageing-0 |
| URL | https://beta.ukdataservice.ac.uk/datacatalogue/doi/?id=5050#21 |
| Title | Geography and Longitudinal Data: Understanding Society The UK Household Longitudinal Study |
| Description | Understanding Society is the largest longitudinal study of its kind and provides crucial information for researchers and policymakers on the changes and stability of people's lives in the UK. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | https://www.understandingsociety.ac.uk/research/impact |
| URL | http://rgdoi.net/10.13140/RG.2.2.15806.54089 |
| Title | Github repository |
| Description | I have uploaded my scripts for my last papers, so that people can replicate the results of my stidies |
| Type Of Material | Computer model/algorithm |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | I have been contacted by many researchers over the last years asking for further clarifications as well as suggestions for their analysis |
| URL | https://github.com/mkatsoulis82 |
| Title | MRC NSHD 2013-2018 Data |
| Description | The MRC National Survey of Health and Development (NSHD) has informed UK health care, education and social policy for more than 50 years and is the oldest and longest running of the British birth cohort studies. Today, with study members in their seventies, the NSHD offers a unique opportunity to explore the long-term biological and social processes of ageing and how ageing is affected by factors acting across the whole of life. From an initial maternity survey of 5362 births recorded in England, Scotland and Wales during one week of March 1946, a socially stratified sample of singleton babies born to married parents was selected for follow-up. These participants have been studied over twenty times throughout their life. During their childhood, the main aim of the NSHD was to investigate how the environment at home and at school affected physical and mental development and educational attainment. During adulthood, the main aim was to investigate how childhood health and development and lifetime social circumstances affected their adult health and function and their change with age. Now, as participants have reached retirement, the research team is developing the NSHD into a life course study of ageing. Study members were asked to attend a clinic at age 60-64 for a range of assessments (or alternatively have a home visit). They were invited for a home visit at 69 years, updating information on health, lifestyle and life circumstances as well as obtaining repeat physical and cognitive measurements. Postal questionnaires were completed before the clinic and home visits. A subset of 500 study members are also being invited to participate in a Neuroscience sub-study. This publication covers data from the NSHD for the years 2013 to 2018. The cohort study is ongoing and further data collections are being added, while component data sets are separately referable. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | Data provided for linkage within UK LLC |
| URL | http://www.nshd.mrc.ac.uk/data/nshd-digital-object-identifiers/mrc-nshd-2013-2018-data/ |
| Title | Millennium Cohort Study |
| Description | Socio-emotional behaviours in early childhood, including self-regulation, emotional problems, and peer problems, have been shown to individually influence academic achievement in primary and secondary school. Environmental and demographic factors have also been shown to influence a child's academic development. The current study extends previous work to consider - concurrently, using structural equation modelling - a broader array of antecedents and measures of social-emotional development to understand their relative effects on academic outcomes. Parent-report data on a nationally representative sample of children (n = 17,035) at ages 3 and 5 years, and academic assessment at age 7, were drawn from the Millennium Cohort Study for longitudinal modelling. Results indicate the individual and collective contribution of socio-emotional, environmental, and demographic antecedents, expanding the current literature on predictors of child academic achievement in primary school. The results suggest that malleable factors in early childhood are important predictors of later academic success, and thus may be viable targets for intervention. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | https://cls.ucl.ac.uk/cls-studies/millennium-cohort-study/ |
| URL | http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/36952/version/1 |
| Title | National Child Development Study: Activity Histories, 1974-2013 |
| Description | The National Child Development Study (NCDS) originated in the Perinatal Mortality Survey (see SN 5565), which examined social and obstetric factors associated with still birth and infant mortality among over 17,000 babies born in Britain in one week in March 1958. Surviving members of this birth cohort have been surveyed on eight further occasions in order to monitor their changing health, education, social and economic circumstances - in 1965 at age 7, 1969 at age 11, 1974 at age 16 (the first three sweeps are also held under SN 5565), 1981 (age 23 - SN 5566), 1991 (age 33 - SN 5567), 1999/2000 (age 41/2 - SN 5578), 2004-2005 (age 46/47 - SN 5579), 2008-2009 (age 50 - SN 6137) and 2013 (age 55 - SN 7669). There have also been surveys of sub-samples of the cohort, the most recent occurring in 1995 (age 37), when a 10% representative sub-sample was assessed for difficulties with basic skills (SN 4992). Finally, during 2002-2004, 9,340 NCDS cohort members participated in a bio-medical survey, carried out by qualified nurses (SN 5594, available under more restrictive Special Licence access conditions; see catalogue record for details). The bio-medical survey did not cover any of the topics included in the 2004/2005 survey. Further NCDS data separate to the main surveys include a response and deaths dataset, parent migration studies, employment, activity and partnership histories, behavioural studies and essays - see the NCDS series page for details. Further information about the NCDS can be found on the Centre for Longitudinal Studies website. How to access genetic and/or bio-medical sample data from a range of longitudinal surveys: A useful overview of the governance routes for applying for genetic and bio-medical sample data, which are not available through the UK Data Service, can be found at Governance of data and sample access on the METADAC (Managing Ethico-social, Technical and Administrative issues in Data Access) website. The purpose of the National Child Development Study: Activity Histories, 1974-2013 was to merge all data on work and non-work activities in successive sweeps into one longitudinal dataset. Data on work and non-work activities lasting one month or more have been collected in all NCDS sweeps from sweep 4 (age 23) onwards. The focus of the questions asked at each sweep vary from: work activities engaged in since leaving school (sweep 4 aged 23); work and non-work activities engaged in since leaving school (sweep 5, aged 33); work and non-work activities engaged in since the last sweep (sweep 6, aged 42); work and non-work activities engaged in since the last sweep or aged 16 (sweep 7, aged 46) work and non-work activities engaged in since 2000, or 2004 if included in sweep 7 (sweep 8, aged 50), work and non-work activities engaged in since 2004, or 2008 if included in sweep 8 (sweep 9, aged 55). Therefore the activity histories will start from the time that the cohort member left school and continue until the interview date of the latest data sweep that each cohort member participated in. The lengths of the activity histories vary depending on the latest sweep that a cohort member was present at. The minimum activity history length recorded is 1 month and the maximum is 480 months (40 years). Gaps in the activity histories occur where a cohort member has not been present at all sweeps and/or where full activity data were not reported. An employment histories dataset was previously created (Ward, 2007). This work was undertaken as part of the Gender Network Project. The current work on NCDS activity histories builds on this previous activity history and incorporates various cleaning of the data. This previous employment history included data up to sweep 7 (2004) only, did not deal with any non-work activities and did not identify duplicate activities (i.e. where an activity was reported again in a later sweep). Latest Edition Information For the second edition (June 2016) the data and documentation were updated to include the latest NCDS wave, extending coverage to 2013. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | https://cls.ucl.ac.uk/cls-studies/1958-national-child-development-study/ |
| URL | https://beta.ukdataservice.ac.uk/datacatalogue/doi/?id=6942#3 |
| Title | SABRE |
| Description | a UK population-based comparison of cardiovascular disease and diabetes in people of European, South Asian and African Caribbean heritage |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | Currently, and in the past, supported many research studies aiding hundreds of publications around the world. |
| URL | https://portal.dementiasplatform.uk/CohortDirectory/Item?fingerPrintID=SABRE |
| Title | TwinsUK |
| Description | The TwinsUK resource is the biggest UK adult twin registry of 12.000 twins used to study the genetic and environmental aetiology of age related complex traits and diseases. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | https://twinsuk.ac.uk/media-and-engagement/overview/ |
| URL | http://service.re3data.org/repository/r3d100011851 |
| Description | BRADFORD TEACHING HOSPITALS NHS FOUNDATION TRUST |
| Organisation | Bradford Teaching Hospitals NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | As described under other output headings |
| Collaborator Contribution | As described under other output headings |
| Impact | As described under other output headings |
| Start Year | 2020 |
| Description | Bristol University-NCS LH&W |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing co-leadership of the project. Providing study data. Contributing to data analysis, results dissemination, study design and conduct, oversight and strategic input. |
| Collaborator Contribution | Professor Jonathan Sterne, is co-Director of the LH&W NCS and PI of the vaccination theme related to this award. Providing co-leadership of the project. Providing study data. Contributing to data analysis, results dissemination, study design and conduct, oversight and strategic input. |
| Impact | doi: https://doi.org/10.1101/2021.11.22.21266512 |
| Start Year | 2020 |
| Description | CLOSER |
| Organisation | University College London |
| Department | Institute of Education (IOE) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Leading on work packages and the teaching aspect of CLOSER. This includes data analysis, preparing and commenting on manuscripts, organising workshops, seminars and conferences. Members of the executive group and CLOSER communications network. |
| Collaborator Contribution | CLOSER (Cohort & Longitudinal Studies Enhancement Resources) aims to maximise their use, value and impact both at home and abroad. Bringing together eight leading studies, the British Library and the UK Data Service, CLOSER works to stimulate interdisciplinary research, develop shared resources, provide training, and share expertise. In this way CLOSER is helping to build the body of knowledge on how life in the UK is changing - both across generations and in comparison to the rest of the world. |
| Impact | Johnson 2017 PMID:28072856 Bann 2017 PMID: 28072856 2 successful bids to the innovation fund 2 successful bids to the innovation fund Bann, D, Johnson, W, Li, L, Kuh, D, Hardy, R. Socioeconomic inequalities in body mass index, weight, and height in childhood and adolescence: coordinated analyses of individual participant data from four British birth cohort studies initiated in 1946, 1958, 1970, and 2000/1. Lancet Public Health 2018 Apr;3(4):e194-e203. doi: 10.1016/S2468-2667(18)30045-8. Epub 2018 Mar 21. |
| Start Year | 2012 |
| Description | CLOSER |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | N/A yet |
| Collaborator Contribution | N/A yet |
| Impact | N/A yet |
| Start Year | 2022 |
| Description | Calibration Study |
| Organisation | University of Southampton |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provide equipment to be used in calibration study. Expertise with analysis and manuscript preparation |
| Collaborator Contribution | PhD student to carry out the analysis of the results of the calibration study and write manuscripts |
| Impact | Numerous poster/abstract presentations at conferences paper in preparation |
| Start Year | 2015 |
| Description | KCL |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | As described under other output headings |
| Collaborator Contribution | As described under other output headings |
| Impact | As described under other output headings |
| Start Year | 2020 |
| Description | Laura Howe Bristol Adversity |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Contribution of NSHD data, data analysis expertise, manuscript preparation, epidemiology expertise |
| Collaborator Contribution | Contribution of data analysis expertise, manuscript preparation, epidemiology expertise |
| Impact | Sucessful grant applications PMID: 32098806 PMID: 30510187 PMID: 30468142 PMID: 29365106 PMID: 29092899 PMID: 28882142 PMID: 28553793 PMID: 27681097 PMID: 27466311 |
| Start Year | 2014 |
| Description | NCD Risk Factor Collaboration |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provide NSHD data and advice on manuscript preparation and analysis |
| Collaborator Contribution | Analysis of data and creation of manuscripts |
| Impact | PMID 27061677 Trends in diabetes PMID 27458798 Adult human height PMID 27115820 Trends in adult BMI PMID 27863813 Trends in blood pressure NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in body mass index, underweight, overweight and obesity from 1975 to 2016: a pooled analysis of 2,416 population-based measurement studies with 128.9 million children, adolescents and adults.PMID: 29029897 2017 Dec 16;390(10113):2627-2642. doi: 10.1016/S0140-6736(17)32129-3. NCD Risk Factor Collaboration 'Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants' International Journal of Epidemiology. . 2018 Mar 19. doi: 10.1093/ije/dyy016. [Epub ahead of print] Most recent wave of data added in |
| Start Year | 2016 |
| Description | NIHR Long Covid |
| Organisation | Bradford Teaching Hospitals NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Long-term health consequences of C-19 (long-COVID) occur frequently. Most infections are not hospitalised; population studies are the place to understand individual and societal challenges of long-COVID. We have an established consortium of experts and platforms uniting linked national primary care registries and population cohorts. The national coverage of primary care registries captures all individuals presenting to their GP, with linked prescribing, consulting, referral and outcome data. Many with long-COVID do not seek care. Population cohorts, with repeat C-19 related questionnaires, overcome this limitation. Further, the standardised pre-pandemic health data enables dissection of the effects of infection versus progression of co-morbidity. Parallel analysis of cohorts and registries will address each question. With NICE, we will quantify adherence to diagnostic and management guidelines in GP records, and pilot a pop-up intervention to enhance adherence. Our findings will enhance diagnostic criteria, identify pathways for bespoke sub-phenotype intervention, and inform plans for health service delivery. |
| Collaborator Contribution | Long-term health consequences of C-19 (long-COVID) occur frequently. Most infections are not hospitalised; population studies are the place to understand individual and societal challenges of long-COVID. We have an established consortium of experts and platforms uniting linked national primary care registries and population cohorts. The national coverage of primary care registries captures all individuals presenting to their GP, with linked prescribing, consulting, referral and outcome data. Many with long-COVID do not seek care. Population cohorts, with repeat C-19 related questionnaires, overcome this limitation. Further, the standardised pre-pandemic health data enables dissection of the effects of infection versus progression of co-morbidity. Parallel analysis of cohorts and registries will address each question. With NICE, we will quantify adherence to diagnostic and management guidelines in GP records, and pilot a pop-up intervention to enhance adherence. Our findings will enhance diagnostic criteria, identify pathways for bespoke sub-phenotype intervention, and inform plans for health service delivery. |
| Impact | Successful grant application to NIHR |
| Start Year | 2020 |
| Description | NIHR Long Covid |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Long-term health consequences of C-19 (long-COVID) occur frequently. Most infections are not hospitalised; population studies are the place to understand individual and societal challenges of long-COVID. We have an established consortium of experts and platforms uniting linked national primary care registries and population cohorts. The national coverage of primary care registries captures all individuals presenting to their GP, with linked prescribing, consulting, referral and outcome data. Many with long-COVID do not seek care. Population cohorts, with repeat C-19 related questionnaires, overcome this limitation. Further, the standardised pre-pandemic health data enables dissection of the effects of infection versus progression of co-morbidity. Parallel analysis of cohorts and registries will address each question. With NICE, we will quantify adherence to diagnostic and management guidelines in GP records, and pilot a pop-up intervention to enhance adherence. Our findings will enhance diagnostic criteria, identify pathways for bespoke sub-phenotype intervention, and inform plans for health service delivery. |
| Collaborator Contribution | Long-term health consequences of C-19 (long-COVID) occur frequently. Most infections are not hospitalised; population studies are the place to understand individual and societal challenges of long-COVID. We have an established consortium of experts and platforms uniting linked national primary care registries and population cohorts. The national coverage of primary care registries captures all individuals presenting to their GP, with linked prescribing, consulting, referral and outcome data. Many with long-COVID do not seek care. Population cohorts, with repeat C-19 related questionnaires, overcome this limitation. Further, the standardised pre-pandemic health data enables dissection of the effects of infection versus progression of co-morbidity. Parallel analysis of cohorts and registries will address each question. With NICE, we will quantify adherence to diagnostic and management guidelines in GP records, and pilot a pop-up intervention to enhance adherence. Our findings will enhance diagnostic criteria, identify pathways for bespoke sub-phenotype intervention, and inform plans for health service delivery. |
| Impact | Successful grant application to NIHR |
| Start Year | 2020 |
| Description | NIHR Long Covid |
| Organisation | London School of Hygiene and Tropical Medicine (LSHTM) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Long-term health consequences of C-19 (long-COVID) occur frequently. Most infections are not hospitalised; population studies are the place to understand individual and societal challenges of long-COVID. We have an established consortium of experts and platforms uniting linked national primary care registries and population cohorts. The national coverage of primary care registries captures all individuals presenting to their GP, with linked prescribing, consulting, referral and outcome data. Many with long-COVID do not seek care. Population cohorts, with repeat C-19 related questionnaires, overcome this limitation. Further, the standardised pre-pandemic health data enables dissection of the effects of infection versus progression of co-morbidity. Parallel analysis of cohorts and registries will address each question. With NICE, we will quantify adherence to diagnostic and management guidelines in GP records, and pilot a pop-up intervention to enhance adherence. Our findings will enhance diagnostic criteria, identify pathways for bespoke sub-phenotype intervention, and inform plans for health service delivery. |
| Collaborator Contribution | Long-term health consequences of C-19 (long-COVID) occur frequently. Most infections are not hospitalised; population studies are the place to understand individual and societal challenges of long-COVID. We have an established consortium of experts and platforms uniting linked national primary care registries and population cohorts. The national coverage of primary care registries captures all individuals presenting to their GP, with linked prescribing, consulting, referral and outcome data. Many with long-COVID do not seek care. Population cohorts, with repeat C-19 related questionnaires, overcome this limitation. Further, the standardised pre-pandemic health data enables dissection of the effects of infection versus progression of co-morbidity. Parallel analysis of cohorts and registries will address each question. With NICE, we will quantify adherence to diagnostic and management guidelines in GP records, and pilot a pop-up intervention to enhance adherence. Our findings will enhance diagnostic criteria, identify pathways for bespoke sub-phenotype intervention, and inform plans for health service delivery. |
| Impact | Successful grant application to NIHR |
| Start Year | 2020 |
| Description | NIHR Long Covid |
| Organisation | National Institute for Health and Care Excellence (NICE) |
| Department | NICE International |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Long-term health consequences of C-19 (long-COVID) occur frequently. Most infections are not hospitalised; population studies are the place to understand individual and societal challenges of long-COVID. We have an established consortium of experts and platforms uniting linked national primary care registries and population cohorts. The national coverage of primary care registries captures all individuals presenting to their GP, with linked prescribing, consulting, referral and outcome data. Many with long-COVID do not seek care. Population cohorts, with repeat C-19 related questionnaires, overcome this limitation. Further, the standardised pre-pandemic health data enables dissection of the effects of infection versus progression of co-morbidity. Parallel analysis of cohorts and registries will address each question. With NICE, we will quantify adherence to diagnostic and management guidelines in GP records, and pilot a pop-up intervention to enhance adherence. Our findings will enhance diagnostic criteria, identify pathways for bespoke sub-phenotype intervention, and inform plans for health service delivery. |
| Collaborator Contribution | Long-term health consequences of C-19 (long-COVID) occur frequently. Most infections are not hospitalised; population studies are the place to understand individual and societal challenges of long-COVID. We have an established consortium of experts and platforms uniting linked national primary care registries and population cohorts. The national coverage of primary care registries captures all individuals presenting to their GP, with linked prescribing, consulting, referral and outcome data. Many with long-COVID do not seek care. Population cohorts, with repeat C-19 related questionnaires, overcome this limitation. Further, the standardised pre-pandemic health data enables dissection of the effects of infection versus progression of co-morbidity. Parallel analysis of cohorts and registries will address each question. With NICE, we will quantify adherence to diagnostic and management guidelines in GP records, and pilot a pop-up intervention to enhance adherence. Our findings will enhance diagnostic criteria, identify pathways for bespoke sub-phenotype intervention, and inform plans for health service delivery. |
| Impact | Successful grant application to NIHR |
| Start Year | 2020 |
| Description | NIHR Long Covid |
| Organisation | Swansea University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Long-term health consequences of C-19 (long-COVID) occur frequently. Most infections are not hospitalised; population studies are the place to understand individual and societal challenges of long-COVID. We have an established consortium of experts and platforms uniting linked national primary care registries and population cohorts. The national coverage of primary care registries captures all individuals presenting to their GP, with linked prescribing, consulting, referral and outcome data. Many with long-COVID do not seek care. Population cohorts, with repeat C-19 related questionnaires, overcome this limitation. Further, the standardised pre-pandemic health data enables dissection of the effects of infection versus progression of co-morbidity. Parallel analysis of cohorts and registries will address each question. With NICE, we will quantify adherence to diagnostic and management guidelines in GP records, and pilot a pop-up intervention to enhance adherence. Our findings will enhance diagnostic criteria, identify pathways for bespoke sub-phenotype intervention, and inform plans for health service delivery. |
| Collaborator Contribution | Long-term health consequences of C-19 (long-COVID) occur frequently. Most infections are not hospitalised; population studies are the place to understand individual and societal challenges of long-COVID. We have an established consortium of experts and platforms uniting linked national primary care registries and population cohorts. The national coverage of primary care registries captures all individuals presenting to their GP, with linked prescribing, consulting, referral and outcome data. Many with long-COVID do not seek care. Population cohorts, with repeat C-19 related questionnaires, overcome this limitation. Further, the standardised pre-pandemic health data enables dissection of the effects of infection versus progression of co-morbidity. Parallel analysis of cohorts and registries will address each question. With NICE, we will quantify adherence to diagnostic and management guidelines in GP records, and pilot a pop-up intervention to enhance adherence. Our findings will enhance diagnostic criteria, identify pathways for bespoke sub-phenotype intervention, and inform plans for health service delivery. |
| Impact | Successful grant application to NIHR |
| Start Year | 2020 |
| Description | NIHR Long Covid |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Long-term health consequences of C-19 (long-COVID) occur frequently. Most infections are not hospitalised; population studies are the place to understand individual and societal challenges of long-COVID. We have an established consortium of experts and platforms uniting linked national primary care registries and population cohorts. The national coverage of primary care registries captures all individuals presenting to their GP, with linked prescribing, consulting, referral and outcome data. Many with long-COVID do not seek care. Population cohorts, with repeat C-19 related questionnaires, overcome this limitation. Further, the standardised pre-pandemic health data enables dissection of the effects of infection versus progression of co-morbidity. Parallel analysis of cohorts and registries will address each question. With NICE, we will quantify adherence to diagnostic and management guidelines in GP records, and pilot a pop-up intervention to enhance adherence. Our findings will enhance diagnostic criteria, identify pathways for bespoke sub-phenotype intervention, and inform plans for health service delivery. |
| Collaborator Contribution | Long-term health consequences of C-19 (long-COVID) occur frequently. Most infections are not hospitalised; population studies are the place to understand individual and societal challenges of long-COVID. We have an established consortium of experts and platforms uniting linked national primary care registries and population cohorts. The national coverage of primary care registries captures all individuals presenting to their GP, with linked prescribing, consulting, referral and outcome data. Many with long-COVID do not seek care. Population cohorts, with repeat C-19 related questionnaires, overcome this limitation. Further, the standardised pre-pandemic health data enables dissection of the effects of infection versus progression of co-morbidity. Parallel analysis of cohorts and registries will address each question. With NICE, we will quantify adherence to diagnostic and management guidelines in GP records, and pilot a pop-up intervention to enhance adherence. Our findings will enhance diagnostic criteria, identify pathways for bespoke sub-phenotype intervention, and inform plans for health service delivery. |
| Impact | Successful grant application to NIHR |
| Start Year | 2020 |
| Description | NIHR Long Covid |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Long-term health consequences of C-19 (long-COVID) occur frequently. Most infections are not hospitalised; population studies are the place to understand individual and societal challenges of long-COVID. We have an established consortium of experts and platforms uniting linked national primary care registries and population cohorts. The national coverage of primary care registries captures all individuals presenting to their GP, with linked prescribing, consulting, referral and outcome data. Many with long-COVID do not seek care. Population cohorts, with repeat C-19 related questionnaires, overcome this limitation. Further, the standardised pre-pandemic health data enables dissection of the effects of infection versus progression of co-morbidity. Parallel analysis of cohorts and registries will address each question. With NICE, we will quantify adherence to diagnostic and management guidelines in GP records, and pilot a pop-up intervention to enhance adherence. Our findings will enhance diagnostic criteria, identify pathways for bespoke sub-phenotype intervention, and inform plans for health service delivery. |
| Collaborator Contribution | Long-term health consequences of C-19 (long-COVID) occur frequently. Most infections are not hospitalised; population studies are the place to understand individual and societal challenges of long-COVID. We have an established consortium of experts and platforms uniting linked national primary care registries and population cohorts. The national coverage of primary care registries captures all individuals presenting to their GP, with linked prescribing, consulting, referral and outcome data. Many with long-COVID do not seek care. Population cohorts, with repeat C-19 related questionnaires, overcome this limitation. Further, the standardised pre-pandemic health data enables dissection of the effects of infection versus progression of co-morbidity. Parallel analysis of cohorts and registries will address each question. With NICE, we will quantify adherence to diagnostic and management guidelines in GP records, and pilot a pop-up intervention to enhance adherence. Our findings will enhance diagnostic criteria, identify pathways for bespoke sub-phenotype intervention, and inform plans for health service delivery. |
| Impact | Successful grant application to NIHR |
| Start Year | 2020 |
| Description | NIHR Long Covid |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Long-term health consequences of C-19 (long-COVID) occur frequently. Most infections are not hospitalised; population studies are the place to understand individual and societal challenges of long-COVID. We have an established consortium of experts and platforms uniting linked national primary care registries and population cohorts. The national coverage of primary care registries captures all individuals presenting to their GP, with linked prescribing, consulting, referral and outcome data. Many with long-COVID do not seek care. Population cohorts, with repeat C-19 related questionnaires, overcome this limitation. Further, the standardised pre-pandemic health data enables dissection of the effects of infection versus progression of co-morbidity. Parallel analysis of cohorts and registries will address each question. With NICE, we will quantify adherence to diagnostic and management guidelines in GP records, and pilot a pop-up intervention to enhance adherence. Our findings will enhance diagnostic criteria, identify pathways for bespoke sub-phenotype intervention, and inform plans for health service delivery. |
| Collaborator Contribution | Long-term health consequences of C-19 (long-COVID) occur frequently. Most infections are not hospitalised; population studies are the place to understand individual and societal challenges of long-COVID. We have an established consortium of experts and platforms uniting linked national primary care registries and population cohorts. The national coverage of primary care registries captures all individuals presenting to their GP, with linked prescribing, consulting, referral and outcome data. Many with long-COVID do not seek care. Population cohorts, with repeat C-19 related questionnaires, overcome this limitation. Further, the standardised pre-pandemic health data enables dissection of the effects of infection versus progression of co-morbidity. Parallel analysis of cohorts and registries will address each question. With NICE, we will quantify adherence to diagnostic and management guidelines in GP records, and pilot a pop-up intervention to enhance adherence. Our findings will enhance diagnostic criteria, identify pathways for bespoke sub-phenotype intervention, and inform plans for health service delivery. |
| Impact | Successful grant application to NIHR |
| Start Year | 2020 |
| Description | NIHR Long Covid |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Long-term health consequences of C-19 (long-COVID) occur frequently. Most infections are not hospitalised; population studies are the place to understand individual and societal challenges of long-COVID. We have an established consortium of experts and platforms uniting linked national primary care registries and population cohorts. The national coverage of primary care registries captures all individuals presenting to their GP, with linked prescribing, consulting, referral and outcome data. Many with long-COVID do not seek care. Population cohorts, with repeat C-19 related questionnaires, overcome this limitation. Further, the standardised pre-pandemic health data enables dissection of the effects of infection versus progression of co-morbidity. Parallel analysis of cohorts and registries will address each question. With NICE, we will quantify adherence to diagnostic and management guidelines in GP records, and pilot a pop-up intervention to enhance adherence. Our findings will enhance diagnostic criteria, identify pathways for bespoke sub-phenotype intervention, and inform plans for health service delivery. |
| Collaborator Contribution | Long-term health consequences of C-19 (long-COVID) occur frequently. Most infections are not hospitalised; population studies are the place to understand individual and societal challenges of long-COVID. We have an established consortium of experts and platforms uniting linked national primary care registries and population cohorts. The national coverage of primary care registries captures all individuals presenting to their GP, with linked prescribing, consulting, referral and outcome data. Many with long-COVID do not seek care. Population cohorts, with repeat C-19 related questionnaires, overcome this limitation. Further, the standardised pre-pandemic health data enables dissection of the effects of infection versus progression of co-morbidity. Parallel analysis of cohorts and registries will address each question. With NICE, we will quantify adherence to diagnostic and management guidelines in GP records, and pilot a pop-up intervention to enhance adherence. Our findings will enhance diagnostic criteria, identify pathways for bespoke sub-phenotype intervention, and inform plans for health service delivery. |
| Impact | Successful grant application to NIHR |
| Start Year | 2020 |
| Description | NIHR Long Covid |
| Organisation | University of York |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Long-term health consequences of C-19 (long-COVID) occur frequently. Most infections are not hospitalised; population studies are the place to understand individual and societal challenges of long-COVID. We have an established consortium of experts and platforms uniting linked national primary care registries and population cohorts. The national coverage of primary care registries captures all individuals presenting to their GP, with linked prescribing, consulting, referral and outcome data. Many with long-COVID do not seek care. Population cohorts, with repeat C-19 related questionnaires, overcome this limitation. Further, the standardised pre-pandemic health data enables dissection of the effects of infection versus progression of co-morbidity. Parallel analysis of cohorts and registries will address each question. With NICE, we will quantify adherence to diagnostic and management guidelines in GP records, and pilot a pop-up intervention to enhance adherence. Our findings will enhance diagnostic criteria, identify pathways for bespoke sub-phenotype intervention, and inform plans for health service delivery. |
| Collaborator Contribution | Long-term health consequences of C-19 (long-COVID) occur frequently. Most infections are not hospitalised; population studies are the place to understand individual and societal challenges of long-COVID. We have an established consortium of experts and platforms uniting linked national primary care registries and population cohorts. The national coverage of primary care registries captures all individuals presenting to their GP, with linked prescribing, consulting, referral and outcome data. Many with long-COVID do not seek care. Population cohorts, with repeat C-19 related questionnaires, overcome this limitation. Further, the standardised pre-pandemic health data enables dissection of the effects of infection versus progression of co-morbidity. Parallel analysis of cohorts and registries will address each question. With NICE, we will quantify adherence to diagnostic and management guidelines in GP records, and pilot a pop-up intervention to enhance adherence. Our findings will enhance diagnostic criteria, identify pathways for bespoke sub-phenotype intervention, and inform plans for health service delivery. |
| Impact | Successful grant application to NIHR |
| Start Year | 2020 |
| Description | NIHR Long Covid |
| Organisation | University of the West of England |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Long-term health consequences of C-19 (long-COVID) occur frequently. Most infections are not hospitalised; population studies are the place to understand individual and societal challenges of long-COVID. We have an established consortium of experts and platforms uniting linked national primary care registries and population cohorts. The national coverage of primary care registries captures all individuals presenting to their GP, with linked prescribing, consulting, referral and outcome data. Many with long-COVID do not seek care. Population cohorts, with repeat C-19 related questionnaires, overcome this limitation. Further, the standardised pre-pandemic health data enables dissection of the effects of infection versus progression of co-morbidity. Parallel analysis of cohorts and registries will address each question. With NICE, we will quantify adherence to diagnostic and management guidelines in GP records, and pilot a pop-up intervention to enhance adherence. Our findings will enhance diagnostic criteria, identify pathways for bespoke sub-phenotype intervention, and inform plans for health service delivery. |
| Collaborator Contribution | Long-term health consequences of C-19 (long-COVID) occur frequently. Most infections are not hospitalised; population studies are the place to understand individual and societal challenges of long-COVID. We have an established consortium of experts and platforms uniting linked national primary care registries and population cohorts. The national coverage of primary care registries captures all individuals presenting to their GP, with linked prescribing, consulting, referral and outcome data. Many with long-COVID do not seek care. Population cohorts, with repeat C-19 related questionnaires, overcome this limitation. Further, the standardised pre-pandemic health data enables dissection of the effects of infection versus progression of co-morbidity. Parallel analysis of cohorts and registries will address each question. With NICE, we will quantify adherence to diagnostic and management guidelines in GP records, and pilot a pop-up intervention to enhance adherence. Our findings will enhance diagnostic criteria, identify pathways for bespoke sub-phenotype intervention, and inform plans for health service delivery. |
| Impact | Successful grant application to NIHR |
| Start Year | 2020 |
| Description | National Core Study LLHW |
| Organisation | Bradford Teaching Hospitals NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Project using data from longitudinal studies to address the impact of COVID-19 and of associated viral suppression measures on health and wealth to inform mitigating strategies. LHA is the lead for this project and is contributing data from its cohorts as well as personnel. We propose uniting distinct but complementary longitudinal studies already engaged in COVID-19 research, enriched with health and administrative data linkage, and enhanced by new, urgent data collection. This collective resource will be mined by a cadre of experienced analysts to provide rapid answers to existing and emerging priority research questions. |
| Collaborator Contribution | Project using data from longitudinal studies to address the impact of COVID-19 and of associated viral suppression measures on health and wealth to inform mitigating strategies. Partners are contriubuting longitudinal studies, data personnel and expertise. |
| Impact | Too early to report |
| Start Year | 2020 |
| Description | National Core Study LLHW |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Project using data from longitudinal studies to address the impact of COVID-19 and of associated viral suppression measures on health and wealth to inform mitigating strategies. LHA is the lead for this project and is contributing data from its cohorts as well as personnel. We propose uniting distinct but complementary longitudinal studies already engaged in COVID-19 research, enriched with health and administrative data linkage, and enhanced by new, urgent data collection. This collective resource will be mined by a cadre of experienced analysts to provide rapid answers to existing and emerging priority research questions. |
| Collaborator Contribution | Project using data from longitudinal studies to address the impact of COVID-19 and of associated viral suppression measures on health and wealth to inform mitigating strategies. Partners are contriubuting longitudinal studies, data personnel and expertise. |
| Impact | Too early to report |
| Start Year | 2020 |
| Description | National Core Study LLHW |
| Organisation | London School of Hygiene and Tropical Medicine (LSHTM) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Project using data from longitudinal studies to address the impact of COVID-19 and of associated viral suppression measures on health and wealth to inform mitigating strategies. LHA is the lead for this project and is contributing data from its cohorts as well as personnel. We propose uniting distinct but complementary longitudinal studies already engaged in COVID-19 research, enriched with health and administrative data linkage, and enhanced by new, urgent data collection. This collective resource will be mined by a cadre of experienced analysts to provide rapid answers to existing and emerging priority research questions. |
| Collaborator Contribution | Project using data from longitudinal studies to address the impact of COVID-19 and of associated viral suppression measures on health and wealth to inform mitigating strategies. Partners are contriubuting longitudinal studies, data personnel and expertise. |
| Impact | Too early to report |
| Start Year | 2020 |
| Description | National Core Study LLHW |
| Organisation | Swansea University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Project using data from longitudinal studies to address the impact of COVID-19 and of associated viral suppression measures on health and wealth to inform mitigating strategies. LHA is the lead for this project and is contributing data from its cohorts as well as personnel. We propose uniting distinct but complementary longitudinal studies already engaged in COVID-19 research, enriched with health and administrative data linkage, and enhanced by new, urgent data collection. This collective resource will be mined by a cadre of experienced analysts to provide rapid answers to existing and emerging priority research questions. |
| Collaborator Contribution | Project using data from longitudinal studies to address the impact of COVID-19 and of associated viral suppression measures on health and wealth to inform mitigating strategies. Partners are contriubuting longitudinal studies, data personnel and expertise. |
| Impact | Too early to report |
| Start Year | 2020 |
| Description | National Core Study LLHW |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Project using data from longitudinal studies to address the impact of COVID-19 and of associated viral suppression measures on health and wealth to inform mitigating strategies. LHA is the lead for this project and is contributing data from its cohorts as well as personnel. We propose uniting distinct but complementary longitudinal studies already engaged in COVID-19 research, enriched with health and administrative data linkage, and enhanced by new, urgent data collection. This collective resource will be mined by a cadre of experienced analysts to provide rapid answers to existing and emerging priority research questions. |
| Collaborator Contribution | Project using data from longitudinal studies to address the impact of COVID-19 and of associated viral suppression measures on health and wealth to inform mitigating strategies. Partners are contriubuting longitudinal studies, data personnel and expertise. |
| Impact | Too early to report |
| Start Year | 2020 |
| Description | National Core Study LLHW |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Project using data from longitudinal studies to address the impact of COVID-19 and of associated viral suppression measures on health and wealth to inform mitigating strategies. LHA is the lead for this project and is contributing data from its cohorts as well as personnel. We propose uniting distinct but complementary longitudinal studies already engaged in COVID-19 research, enriched with health and administrative data linkage, and enhanced by new, urgent data collection. This collective resource will be mined by a cadre of experienced analysts to provide rapid answers to existing and emerging priority research questions. |
| Collaborator Contribution | Project using data from longitudinal studies to address the impact of COVID-19 and of associated viral suppression measures on health and wealth to inform mitigating strategies. Partners are contriubuting longitudinal studies, data personnel and expertise. |
| Impact | Too early to report |
| Start Year | 2020 |
| Description | National Core Study LLHW |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Project using data from longitudinal studies to address the impact of COVID-19 and of associated viral suppression measures on health and wealth to inform mitigating strategies. LHA is the lead for this project and is contributing data from its cohorts as well as personnel. We propose uniting distinct but complementary longitudinal studies already engaged in COVID-19 research, enriched with health and administrative data linkage, and enhanced by new, urgent data collection. This collective resource will be mined by a cadre of experienced analysts to provide rapid answers to existing and emerging priority research questions. |
| Collaborator Contribution | Project using data from longitudinal studies to address the impact of COVID-19 and of associated viral suppression measures on health and wealth to inform mitigating strategies. Partners are contriubuting longitudinal studies, data personnel and expertise. |
| Impact | Too early to report |
| Start Year | 2020 |
| Description | National Core Study LLHW |
| Organisation | University of Glasgow |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Project using data from longitudinal studies to address the impact of COVID-19 and of associated viral suppression measures on health and wealth to inform mitigating strategies. LHA is the lead for this project and is contributing data from its cohorts as well as personnel. We propose uniting distinct but complementary longitudinal studies already engaged in COVID-19 research, enriched with health and administrative data linkage, and enhanced by new, urgent data collection. This collective resource will be mined by a cadre of experienced analysts to provide rapid answers to existing and emerging priority research questions. |
| Collaborator Contribution | Project using data from longitudinal studies to address the impact of COVID-19 and of associated viral suppression measures on health and wealth to inform mitigating strategies. Partners are contriubuting longitudinal studies, data personnel and expertise. |
| Impact | Too early to report |
| Start Year | 2020 |
| Description | National Core Study LLHW |
| Organisation | University of Leicester |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Project using data from longitudinal studies to address the impact of COVID-19 and of associated viral suppression measures on health and wealth to inform mitigating strategies. LHA is the lead for this project and is contributing data from its cohorts as well as personnel. We propose uniting distinct but complementary longitudinal studies already engaged in COVID-19 research, enriched with health and administrative data linkage, and enhanced by new, urgent data collection. This collective resource will be mined by a cadre of experienced analysts to provide rapid answers to existing and emerging priority research questions. |
| Collaborator Contribution | Project using data from longitudinal studies to address the impact of COVID-19 and of associated viral suppression measures on health and wealth to inform mitigating strategies. Partners are contriubuting longitudinal studies, data personnel and expertise. |
| Impact | Too early to report |
| Start Year | 2020 |
| Description | National Core Study LLHW |
| Organisation | University of Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Project using data from longitudinal studies to address the impact of COVID-19 and of associated viral suppression measures on health and wealth to inform mitigating strategies. LHA is the lead for this project and is contributing data from its cohorts as well as personnel. We propose uniting distinct but complementary longitudinal studies already engaged in COVID-19 research, enriched with health and administrative data linkage, and enhanced by new, urgent data collection. This collective resource will be mined by a cadre of experienced analysts to provide rapid answers to existing and emerging priority research questions. |
| Collaborator Contribution | Project using data from longitudinal studies to address the impact of COVID-19 and of associated viral suppression measures on health and wealth to inform mitigating strategies. Partners are contriubuting longitudinal studies, data personnel and expertise. |
| Impact | Too early to report |
| Start Year | 2020 |
| Description | National Core Study LLHW |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Project using data from longitudinal studies to address the impact of COVID-19 and of associated viral suppression measures on health and wealth to inform mitigating strategies. LHA is the lead for this project and is contributing data from its cohorts as well as personnel. We propose uniting distinct but complementary longitudinal studies already engaged in COVID-19 research, enriched with health and administrative data linkage, and enhanced by new, urgent data collection. This collective resource will be mined by a cadre of experienced analysts to provide rapid answers to existing and emerging priority research questions. |
| Collaborator Contribution | Project using data from longitudinal studies to address the impact of COVID-19 and of associated viral suppression measures on health and wealth to inform mitigating strategies. Partners are contriubuting longitudinal studies, data personnel and expertise. |
| Impact | Too early to report |
| Start Year | 2020 |
| Description | Network of Applied Statisticians in Health |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I started collaborating with other statisticians at UCL, with whom we share common interests in the statistical analysis of different types of health databases. I mainly help people who want to analyse Electronic Health Records. In 2022, I organised a short course on "Target Trial Emulation", that had more than 200 participants From March 2023, I have been one of the network leads the NASH network, see https://www.ucl.ac.uk/population-health-sciences/research/network-applied-statisticians-health |
| Collaborator Contribution | Their contribution was the useful feedback and comments that I had on my projects. |
| Impact | I am writing one paper, in which I received useful comments from 2 members of this team (Bianca de Stavola and Manuel Gomes), who will be included as co-authors. |
| Start Year | 2018 |
| Description | UCLEB |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | NSHD data sharing and epideomiological experitise |
| Collaborator Contribution | Maximising research potential of NSHD Prof Aroon Hinorani brings in CVD and genetic skills and manages the collaboration with several CVD cohort studies at UCL and Edinburgh, including NSHD. Data sharing |
| Impact | UCL Biomedical Research Centre High Impact Grant awarded BHF programme grant under review 23977022 White 26781229 Neusch 25979724 Talmund 25475436 White 26781229 Beaney 27549350 Morris 27365493 Prins 27327646 Beaney KE. Functional analysis of the coronary heart disease risk locus on chromosome 21q22. PMID:28458444 PMC5387827 Dale C. Causal Associations of Adiposity and Body Fat Distribution with Coronary Heart Disease, Stroke Subtypes and Type 2 Diabetes: A Mendelian Randomization Analysis. PMID: 28500271 PMC5515354 Fairoozy R. Identifying Low Density Lipoprotein Cholesterol Associated Variants in the Annexin A2 (ANXA2) Gene. PMID:28456096 PMC5446264 Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, Kavousi M, Dale C, Smith AV, Hofer E, van Leeuwen EM, Nolte IM, Lu L, Scholz M, Sargurupremraj M, Pitkänen N, Franzén O, Joshi PK, Noordam R, Marioni RE, Hwang SJ, Musani SK, Schminke U, Palmas W, Isaacs A, Correa A, Zonderman AB, Hofman A, Teumer A, Cox AJ, Uitterlinden AG, Wong A, Smit AJ, Newman AB, Britton A, Ruusalepp A, Sennblad B, Hedblad B, Pasaniuc B, Penninx BW, Langefeld CD, Wassel CL, Tzourio C, Fava C, Baldassarre D, O'Leary DH, Teupser D, Kuh D, Tremoli E, Mannarino E, Grossi E, Boerwinkle E, Schadt EE, Ingelsson E, Veglia F, Rivadeneira F, Beutner F, Chauhan G, Heiss G, Snieder H, Campbell H, Völzke H, Markus HS, Deary IJ, Jukema JW, de Graaf J, Price J, Pott J, Hopewell JC, Liang J, Thiery J, Engmann J, Gertow K, Rice K, Taylor KD, Dhana K, Kiemeney LALM, Lind L, Raffield LM, Launer LJ, Holdt LM, Dörr M, Dichgans M, Traylor M, Sitzer M, Kumari M, Kivimaki M, Nalls MA, Melander O, Raitakari O, Franco OH, Rueda-Ochoa OL, Roussos P, Whincup PH, Amouyel P, Giral P, Anugu P, Wong Q, Malik R, Rauramaa R, Burkhardt R, Hardy R, Schmidt R, de Mutsert R, Morris RW, Strawbridge RJ, Wannamethee SG, Hägg S, Shah S, McLachlan S, Trompet S, Seshadri S, Kurl S, Heckbert SR, Ring S, Harris TB, Lehtimäki T, Galesloot TE, Shah T, de Faire U, Plagnol V, Rosamond WD, Post W, Zhu X, Zhang X, Guo X, Saba Y; MEGASTROKE Consortium, Dehghan A, Seldenrijk A, Morrison AC, Hamsten A, Psaty BM, van Duijn CM, Lawlor DA, Mook-Kanamori DO, Bowden DW, Schmidt H, Wilson JF, Wilson JG, Rotter JI, Wardlaw JM, Deanfield J, Halcox J, Lyytikäinen LP, Loeffler M, Evans MK, Debette S, Humphries SE, Völker U, Gudnason V, Hingorani AD, Björkegren JLM, Casas JP, O'Donnell CJ. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nat Commun. 2018 Dec 3;9(1):5141. doi: 10.1038/s41467-018-07340-5. PMID: 30510157 PMID: 32114887 PMID: 31088856 |
| Start Year | 2008 |
| Description | UCLEB |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | NSHD data sharing and epideomiological experitise |
| Collaborator Contribution | Maximising research potential of NSHD Prof Aroon Hinorani brings in CVD and genetic skills and manages the collaboration with several CVD cohort studies at UCL and Edinburgh, including NSHD. Data sharing |
| Impact | UCL Biomedical Research Centre High Impact Grant awarded BHF programme grant under review 23977022 White 26781229 Neusch 25979724 Talmund 25475436 White 26781229 Beaney 27549350 Morris 27365493 Prins 27327646 Beaney KE. Functional analysis of the coronary heart disease risk locus on chromosome 21q22. PMID:28458444 PMC5387827 Dale C. Causal Associations of Adiposity and Body Fat Distribution with Coronary Heart Disease, Stroke Subtypes and Type 2 Diabetes: A Mendelian Randomization Analysis. PMID: 28500271 PMC5515354 Fairoozy R. Identifying Low Density Lipoprotein Cholesterol Associated Variants in the Annexin A2 (ANXA2) Gene. PMID:28456096 PMC5446264 Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, Kavousi M, Dale C, Smith AV, Hofer E, van Leeuwen EM, Nolte IM, Lu L, Scholz M, Sargurupremraj M, Pitkänen N, Franzén O, Joshi PK, Noordam R, Marioni RE, Hwang SJ, Musani SK, Schminke U, Palmas W, Isaacs A, Correa A, Zonderman AB, Hofman A, Teumer A, Cox AJ, Uitterlinden AG, Wong A, Smit AJ, Newman AB, Britton A, Ruusalepp A, Sennblad B, Hedblad B, Pasaniuc B, Penninx BW, Langefeld CD, Wassel CL, Tzourio C, Fava C, Baldassarre D, O'Leary DH, Teupser D, Kuh D, Tremoli E, Mannarino E, Grossi E, Boerwinkle E, Schadt EE, Ingelsson E, Veglia F, Rivadeneira F, Beutner F, Chauhan G, Heiss G, Snieder H, Campbell H, Völzke H, Markus HS, Deary IJ, Jukema JW, de Graaf J, Price J, Pott J, Hopewell JC, Liang J, Thiery J, Engmann J, Gertow K, Rice K, Taylor KD, Dhana K, Kiemeney LALM, Lind L, Raffield LM, Launer LJ, Holdt LM, Dörr M, Dichgans M, Traylor M, Sitzer M, Kumari M, Kivimaki M, Nalls MA, Melander O, Raitakari O, Franco OH, Rueda-Ochoa OL, Roussos P, Whincup PH, Amouyel P, Giral P, Anugu P, Wong Q, Malik R, Rauramaa R, Burkhardt R, Hardy R, Schmidt R, de Mutsert R, Morris RW, Strawbridge RJ, Wannamethee SG, Hägg S, Shah S, McLachlan S, Trompet S, Seshadri S, Kurl S, Heckbert SR, Ring S, Harris TB, Lehtimäki T, Galesloot TE, Shah T, de Faire U, Plagnol V, Rosamond WD, Post W, Zhu X, Zhang X, Guo X, Saba Y; MEGASTROKE Consortium, Dehghan A, Seldenrijk A, Morrison AC, Hamsten A, Psaty BM, van Duijn CM, Lawlor DA, Mook-Kanamori DO, Bowden DW, Schmidt H, Wilson JF, Wilson JG, Rotter JI, Wardlaw JM, Deanfield J, Halcox J, Lyytikäinen LP, Loeffler M, Evans MK, Debette S, Humphries SE, Völker U, Gudnason V, Hingorani AD, Björkegren JLM, Casas JP, O'Donnell CJ. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nat Commun. 2018 Dec 3;9(1):5141. doi: 10.1038/s41467-018-07340-5. PMID: 30510157 PMID: 32114887 PMID: 31088856 |
| Start Year | 2008 |
| Description | UCLEB |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | NSHD data sharing and epideomiological experitise |
| Collaborator Contribution | Maximising research potential of NSHD Prof Aroon Hinorani brings in CVD and genetic skills and manages the collaboration with several CVD cohort studies at UCL and Edinburgh, including NSHD. Data sharing |
| Impact | UCL Biomedical Research Centre High Impact Grant awarded BHF programme grant under review 23977022 White 26781229 Neusch 25979724 Talmund 25475436 White 26781229 Beaney 27549350 Morris 27365493 Prins 27327646 Beaney KE. Functional analysis of the coronary heart disease risk locus on chromosome 21q22. PMID:28458444 PMC5387827 Dale C. Causal Associations of Adiposity and Body Fat Distribution with Coronary Heart Disease, Stroke Subtypes and Type 2 Diabetes: A Mendelian Randomization Analysis. PMID: 28500271 PMC5515354 Fairoozy R. Identifying Low Density Lipoprotein Cholesterol Associated Variants in the Annexin A2 (ANXA2) Gene. PMID:28456096 PMC5446264 Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, Kavousi M, Dale C, Smith AV, Hofer E, van Leeuwen EM, Nolte IM, Lu L, Scholz M, Sargurupremraj M, Pitkänen N, Franzén O, Joshi PK, Noordam R, Marioni RE, Hwang SJ, Musani SK, Schminke U, Palmas W, Isaacs A, Correa A, Zonderman AB, Hofman A, Teumer A, Cox AJ, Uitterlinden AG, Wong A, Smit AJ, Newman AB, Britton A, Ruusalepp A, Sennblad B, Hedblad B, Pasaniuc B, Penninx BW, Langefeld CD, Wassel CL, Tzourio C, Fava C, Baldassarre D, O'Leary DH, Teupser D, Kuh D, Tremoli E, Mannarino E, Grossi E, Boerwinkle E, Schadt EE, Ingelsson E, Veglia F, Rivadeneira F, Beutner F, Chauhan G, Heiss G, Snieder H, Campbell H, Völzke H, Markus HS, Deary IJ, Jukema JW, de Graaf J, Price J, Pott J, Hopewell JC, Liang J, Thiery J, Engmann J, Gertow K, Rice K, Taylor KD, Dhana K, Kiemeney LALM, Lind L, Raffield LM, Launer LJ, Holdt LM, Dörr M, Dichgans M, Traylor M, Sitzer M, Kumari M, Kivimaki M, Nalls MA, Melander O, Raitakari O, Franco OH, Rueda-Ochoa OL, Roussos P, Whincup PH, Amouyel P, Giral P, Anugu P, Wong Q, Malik R, Rauramaa R, Burkhardt R, Hardy R, Schmidt R, de Mutsert R, Morris RW, Strawbridge RJ, Wannamethee SG, Hägg S, Shah S, McLachlan S, Trompet S, Seshadri S, Kurl S, Heckbert SR, Ring S, Harris TB, Lehtimäki T, Galesloot TE, Shah T, de Faire U, Plagnol V, Rosamond WD, Post W, Zhu X, Zhang X, Guo X, Saba Y; MEGASTROKE Consortium, Dehghan A, Seldenrijk A, Morrison AC, Hamsten A, Psaty BM, van Duijn CM, Lawlor DA, Mook-Kanamori DO, Bowden DW, Schmidt H, Wilson JF, Wilson JG, Rotter JI, Wardlaw JM, Deanfield J, Halcox J, Lyytikäinen LP, Loeffler M, Evans MK, Debette S, Humphries SE, Völker U, Gudnason V, Hingorani AD, Björkegren JLM, Casas JP, O'Donnell CJ. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nat Commun. 2018 Dec 3;9(1):5141. doi: 10.1038/s41467-018-07340-5. PMID: 30510157 PMID: 32114887 PMID: 31088856 |
| Start Year | 2008 |
| Title | An AI system to fully automate and improve accuracy and precision of cardiac MRI measurements. |
| Description | The AI system ingests the images from a cardiac MRI study, and automatically analyses the images that contain information about heart structure and function. The measurements are fully automated and, more importantly, objective. The precision of the analysis beats that of an expert clinician, which has the potential of translating to improved clinical outcomes and more statistical power in clinical trials. |
| Type Of Technology | New/Improved Technique/Technology |
| Year Produced | 2022 |
| Impact | Clinical application to ~8000 cardiac patients. Used as the core analysis in 3 (and growing) clinical trials. Formed the core IP of a UCL spin-out (Mycardium AI) |
| Title | New data sharing platform - Skylark |
| Description | Skylark is our new data sharing platform. Skylark is aimed at providing researchers with all the information they need to apply for survey data from the NSHD. Skylark is composed of two companion systems: A wiki (https://skylark.ucl.ac.uk) provides users with a detailed description of the study including all data collections across its 70+ years. The wiki includes: 1. background information about the NSHD; 2. all annotated questionnaires and other paper instruments; 3. a description of the major topics, including information on repeated measures and standard variables; 4. information about the variable search facility and guides on how to locate variables; 5. NSHD information governance; 6. a complete description of the NSHD data sharing process, including all the forms necessary to set up a data sharing agreement and submit a data access request. A variable search facility (https://skylark/ucl.ac.uk/Skylark) provides a platform to locate metadata covering more than 25,000 NSHD variables. Users will need to register, before they can log in to search for variables of interest, which can then be added to personal shopping baskets and saved. Following a successful data sharing application and satisfactory information security assessment, these baskets will then be processed by NSHD staff and the data sent out. This is different from our current data sharing platform, SWIFT, is that it is more secure, transparent and the process of data sharing will be more automated. Data applications are now all completed on line improvements are continuously being made to this platform |
| Type Of Technology | New/Improved Technique/Technology |
| Year Produced | 2018 |
| Impact | We are in the testing phase, with a full launch scheduled for end of September / beginning of October. |
| URL | https://skylark.ucl.ac.uk |
| Description | 75th birthday celebratory talk series |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | A series of five talks were orgnaised for the birthday week in March to celbrate 75 years of the NSHD. The topics covered were recent finding, future plans, covid research and cross cohort work, the history of the NSHD and archive and how the childhood questionnaires are being used in current research. The talks were live streamed from youtube and we had on average 100 peopl ewatching and lots of questions were asked throughout each session. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Blog post about diet and new dietary measures guides (CLOSER) |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Scientist worked with CLOSER to produce a new online guide on dietary measures and estimated nutrient intake within and across eight CLOSER partner studies and wrote a blog post talkingall about diet - what it is, how it's measured and why it matters. |
| Year(s) Of Engagement Activity | 2020 |
| URL | http://www.closer.ac.uk/news-opinion/blog/diet-what-is-it-and-how-do-we/?utm_medium=referral&utm_sou... |
| Description | British Heart Foundation's 60th Birthday Parliamentary Reception |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Policymakers/politicians |
| Results and Impact | We presented an update of our research and data science methods to MPs at the British Heart Foundation's 60th Birthday Parliamentary Reception. This was held at the House of Commons and hosted by Elliot Colburn MP on March 2nd 2022. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.bhf.org.uk/what-we-do/birthday |
| Description | British Science Week Social Media Campaign |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | This year the Unit ran a social media campaign during British Science Week to showcase the many 'connections' that the unit has. |
| Year(s) Of Engagement Activity | 2023 |
| Description | CLOSER - Preparing for the future III |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Longitudinal population studies (LPS) currently face a range of challenges. With the world still dealing with COVID-19 and its far-reaching impacts, the value of longitudinal studies, with the wealth of data already collected in the years before the pandemic, and their ability to track individuals during and after the pandemic, has never been greater. But what will these studies look like in a post-COVID world? How will the experiences during the pandemic influence approaches to policy engagement and impact, the adoption of novel approaches to data collection and emerging technologies, and to participant and public engagement? How are studies harnessing the opportunities that have arisen during the pandemic and what learning has been gained? Following the success of CLOSER's 2018 and 2020 Preparing for the future conferences, in January 2022 we brought the LPS community together again to identify ways to tackle shared challenges. This online conference, delivered over three days, was a collaborative, interactive event with a strong focus on sharing best practice and problem solving. The programme was shaped by consultation with UK and international longitudinal studies. Each session involved short presentations of exemplar work in a given area, followed by facilitated group discussions and the chance for delegates to share their own experiences. The conference addressed the following topics: The impact of COVID-19 on longitudinal population studies Influencing policy Data linkage New forms of data collection Participant and public engagement Influencing policy Partnerships facilitate policy translation - a case study from Growing Up in New Zealand -Susan Morton, Growing Up in New Zealand Watch the talk | Download the slides [PDF] | View the illustrated summary [JPG] Generating policy impact: insights from Understanding Society Policy and Partnerships Unit - Raj Patel, Understanding Society Watch the talk | Download the slides [PDF] | View the illustrated summary [JPG] |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.closer.ac.uk/event/2022-conference/ |
| Description | Human Rights Lawyers Association Systemic Racism Event 29 July: Panellist Group |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Took part in a podcast organised by the Human Rights Lawyers Association to highlight issues related to covid and race. Well atended session with lots of questions during the event |
| Year(s) Of Engagement Activity | 2020 |
| Description | In2Science |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | In2scienceUK empowers young people from disadvantaged backgrounds to achieve their potential through life changing opportunities that give them insights into STEM careers and research and boosts their skills and confidence. Two students joined the Unit for a week and were shown various aspects of the research and the clinic activities. One of the students went on to apply for University course. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Interview for national news - BAME and covid |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Nish Chaturvedi was interviewed for numerous articles commenting on why coronavirus hit people from BAME communities so hard https://www.wired.co.uk/article/bame-communities-coronavirus-uk; https://www.theguardian.com/world/2020/aug/08/the-virus-piggybacked-on-racism-why-did-covid-19-hit-bame-families-so-hard; https://www.theguardian.com/world/2020/jun/12/poorest-areas-of-england-and-wales-hit-hardest-by-covid-19-ons; https://www.theguardian.com/world/2020/apr/22/why-are-people-from-bame-groups-dying-disproportionately-of-covid-19. Numerous comments and debates were had as a result of this and lead to Nish speaking at a Human Rights Lawyers Association Systemic Racism Event |
| Year(s) Of Engagement Activity | 2020 |
| Description | Invited Talk: BIHS 2021 Resilience in Research |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Chloe Park gave an Invited Talk at the Young Investigators session of the BIHS meeting, Brighton, Sep 2021, on Resilience in Research |
| Year(s) Of Engagement Activity | 2021 |
| Description | Its all academic 2019 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | LHA took part in the UCL Its all academic festival. LHA had their Game of Life activity which was an interactive game where participants learnt about our longitudinal research into healthy ageing. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Keir Starmer MP Research visit |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Local MP, Sir Keir Starmer was invited to the MRC Festival of Medical Research but he was unable to attend. However, he offered to visit the units, who were taking part in the Festival. We and the MRC LMBC took up the opportunity to meet Keir. He met with staff, who explained about the cohort studies we have at the Unit - MRC NSHD, SABRE, LINKAGE and Insight 46 (a substudy of the MRC NSHD). |
| Year(s) Of Engagement Activity | 2019 |
| Description | LH&W and Convalescence Study conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | The first face-to-face LH&W and Convalescence Study conference took place on November 17th/18th at The Danubius Hotel Regents Park. ~90 researchers from 15 institutions attended and made the event a great success. LHA researchers featured throughout the conference, including presentations from Professor Nish Chaturvedi, Dr Kishan Patel, Dr Khaled Rjoob and Dr Wels Jacques. Thank you to Dr Alisia Carnemolla , Dr Dylan Williams and Dr Chloe Park for organising the event. |
| Year(s) Of Engagement Activity | 2022 |
| Description | MRC Festival June 2019 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | LHA hosted a Science Fair at UCL with the MRC Laboratory for Medical Cell Biology and the MRC Prion. This was a free family fun day for all ages and included hands-on activities, interactive demonstrations, games and exhibitions. LHA had their Game of Life activity which was an interactive game where participants learnt about our longitudinal research into healthy ageing. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Media interest in Respiratory paper |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | This paper was picked up by a number of media outlets - Early childhood lower respiratory tract infection and premature adult death from respiratory disease in Great Britain: a national birth cohort study |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.ucl.ac.uk/news/headlines/2023/mar/respiratory-disease-childhood-linked-premature-death-a... |
| Description | Media interest in excerise and brain function paper |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Media interest on a paper around Exercising at least once a month linked to better brain function in later life Read: Guardian, More: Mail Online, CNN, Times (£), Irish Times, Mirror (2), Med Page Today, Independent, Evening Standard, Express, Telegraph (£), i News, U.S. News,Yahoo! News, CBS News, UCL News |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.ucl.ac.uk/news/headlines/2023/feb/exercising-least-once-month-linked-better-brain-functi... |
| Description | Member of the International Society for Clinical Biostatistics (Education committee) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | I have been a member of the ISCB committee for 2 years. Our goal is to support and organise educational activities, such as short-courses, webinars and seminars on contemporary methods in clinical biostatistics |
| Year(s) Of Engagement Activity | 2021,2022,2023 |
| URL | https://iscb.info/education/ |
| Description | NSHD 76th Birthday Pack |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Study participants or study members |
| Results and Impact | We sent a birthday card and newsletter to the NSHD study members |
| Year(s) Of Engagement Activity | 2022 |
| Description | NSHD Advisory Panel |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | We have 2 NSHD Advisory Panels. A discussion group with 12 study members and a email/postal group with 24 study members. We aim to hold 2 meetings of the discussion group per year. We send out information to the email/postal group as and when we have questions we would like to ask the study members. |
| Year(s) Of Engagement Activity | 2022,2023 |
| Description | NSHD Study Members Birthday Pack |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Study participants or study members |
| Results and Impact | Every year for the study member's birthday we send them out a birthday card and newsletter |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://nshd.mrc.ac.uk/newsletter-2023/ |
| Description | NSHD featured in science programme QUARKS in Germany |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | NSHD featured in science programme QUARKS in German 1st television. Increased reputation and awareness of NSHD. |
| Year(s) Of Engagement Activity | 2020 |
| URL | http://www.planet-schule.de/sf/php/sendungen.php?sendung=10879 |
| Description | Non communicable diseaes in South Asia Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | NCD in South Asia Workshop 23rd to 24th Jan 2020. Led by Academy of Medical Sciences. Steering committee member, chair and facilitator. Bringing regional experts in NCDs together to discuss research state, gaps, and initiatives. Following the workshop, a written report is being produced and will be disseminated to stakeholders within the region and the UK highlighting the identified next steps to help tackle NCDs South Asia. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Press Release - role of cognitive reserve markers from NSHD |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Paper picked up for a press release programme |
| Year(s) Of Engagement Activity | 2022 |
| Description | School talk for British Science Week |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | For British Science Week 2023, Dr Chloe Park visited Kings Court First School in Old Windsor to talk to 5-9 year old about being a scientist. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Science Museum Lates 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | LHA took their Life Course Golf Course activity to the Science Museum Lates. Participants were taken round the miniature golf course by our researchers (the caddy) and learnt about our longitudinal research into healthy ageing |
| Year(s) Of Engagement Activity | 2019 |
| Description | Vent project podcast |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Nish took part in a podcast as part of the VENT Project. Part of our new Covid-19 Fact Checkers mini-series which aims to answer your questions and anxieties around Covid-19. This episode, Amelia is joined by co-host Suprina Thapa, Science Journalist, Layal Liverpool and Epidemiologist Prof. Nishi Chaturvedi. VICE UK have teamed up with Brent, the London Borough of Culture 2020, to launch this year-long project: VENT.VENT is an experiment in podcasting, handing the megaphone of VICE UK's huge platform to the young people of a single London borough, amplifying their passions and their fears to a truly international audience. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.brent2020.co.uk/brent-stories/vent-covid-19-fact-checkers-episode-2/ |