Physiological resilience: mechanisms and consequences
Lead Research Organisation:
University College London
Department Name: UNLISTED
Abstract
Resilience, the ability to ‘bounce back’ from a challenge, gets worse with age. For example, older people are less likely to make a full recovery to their pre-illness state from a fall, infection or surgery. This is also true for the response to daily life challenges; for example, older people lose the ability to prevent the fall in blood pressure on standing, and their blood pressure subsequently takes longer to return to normal, than younger people. Similarly, levels of circulating glucose (a simple sugar) in response to a meal takes longer to return to normal in older than younger people. We suggest that loss of resilience is an early marker of poor outcomes, specifically progressive loss of function, increased risk of disease, frailty and death.
We will measure responses to controlled stressors in the clinic (e.g. standing up, physical activity, thinking). This will allow us to determine if a person shows early signs that they will be at more risk of disease and disability in the future. Potentially, we could use measures of resilience to identify people at high risk and may find new ways to intervene to improve their resilience which would lead to better outcomes.
We will measure responses to controlled stressors in the clinic (e.g. standing up, physical activity, thinking). This will allow us to determine if a person shows early signs that they will be at more risk of disease and disability in the future. Potentially, we could use measures of resilience to identify people at high risk and may find new ways to intervene to improve their resilience which would lead to better outcomes.
Technical Summary
Aim
We will use dynamic phenotyping to investigate mechanisms underlying impaired physiological resilience with ageing, and quantify its association with functional change and clinical events.
Importance of research
Resilience – the ability to resist or recover from stressors – declines with age, and determines functional status, loss of independence and mortality. While resilience is multifaceted, underlying pathways of impaired resilience are likely to be common across systems, but are poorly understood.
Objectives
Quantify the impact of controlled dynamic stressors on resilience, and determine the extent to which responses to individual stressors are correlated.
Understand the life course environmental exposures, and midlife molecular and physiological determinants of resilience in NSHD.
Explore the consequences of the spectrum of resilience in terms of hospital admission and events
Methodology
Physiological responses to everyday dynamic stressors delivered in an experimental clinic setting, such as mobility, cognitive tasks, orthostatic challenge and food ingestion, will be used to quantify resilience across multiple systems (cardiovascular, metabolic, skeletal muscle, neurological). Participants from NSHD (with rich data on determinants of resilience) will be studied.
Potential translational impact
Identification of predictive resilience measures and underlying pathways would highlight novel biomarkers to categorise older people at high risk of adverse outcomes, and novel targets for intervention.
We will use dynamic phenotyping to investigate mechanisms underlying impaired physiological resilience with ageing, and quantify its association with functional change and clinical events.
Importance of research
Resilience – the ability to resist or recover from stressors – declines with age, and determines functional status, loss of independence and mortality. While resilience is multifaceted, underlying pathways of impaired resilience are likely to be common across systems, but are poorly understood.
Objectives
Quantify the impact of controlled dynamic stressors on resilience, and determine the extent to which responses to individual stressors are correlated.
Understand the life course environmental exposures, and midlife molecular and physiological determinants of resilience in NSHD.
Explore the consequences of the spectrum of resilience in terms of hospital admission and events
Methodology
Physiological responses to everyday dynamic stressors delivered in an experimental clinic setting, such as mobility, cognitive tasks, orthostatic challenge and food ingestion, will be used to quantify resilience across multiple systems (cardiovascular, metabolic, skeletal muscle, neurological). Participants from NSHD (with rich data on determinants of resilience) will be studied.
Potential translational impact
Identification of predictive resilience measures and underlying pathways would highlight novel biomarkers to categorise older people at high risk of adverse outcomes, and novel targets for intervention.
People |
ORCID iD |
Publications
Young HML
(2022)
Living with frailty and haemodialysis: a qualitative study.
in BMC nephrology
Ye Y
(2023)
Cardiovascular imaging in conduction system pacing: What does the clinician need?
in Pacing and clinical electrophysiology : PACE
Wood N
(2021)
Childhood correlates of adult positive mental well-being in three British longitudinal studies.
in Journal of epidemiology and community health
Williams DM
(2020)
On the use of Mendelian randomization to assess the consequences of metformin exposure.
in International journal of epidemiology
Williams D
(2020)
Evaluating Lipid-Lowering Drug Targets for Parkinson's Disease Prevention with Mendelian Randomization
in Annals of Neurology
Watling CZ
(2023)
Associations between food group intakes and circulating insulin-like growth factor-I in the UK Biobank: a cross-sectional analysis.
in European journal of nutrition
Ward J
(2023)
Testing for association between exonic glucagon-like peptide 1 receptor mutation with physical and brain health traits in UK Biobank.
in Diabetes, obesity & metabolism
Wagen AZ
(2022)
Life course, genetic, and neuropathological associations with brain age in the 1946 British Birth Cohort: a population-based study.
in The lancet. Healthy longevity
Vyas MV
(2021)
Cardiovascular disease recurrence and long-term mortality in a tri-ethnic British cohort.
in Heart (British Cardiac Society)
Tsui Alex
(2023)
Extremes of baseline cognitive function determine the severity of delirium: a population study
in BRAIN
Related Projects
| Project Reference | Relationship | Related To | Start | End | Award Value |
|---|---|---|---|---|---|
| MC_UU_00019/1 | 01/04/2019 | 31/03/2024 | £4,569,000 | ||
| MC_UU_00019/2 | Transfer | MC_UU_00019/1 | 01/04/2019 | 31/03/2024 | £1,784,000 |
| MC_UU_00019/3 | Transfer | MC_UU_00019/2 | 01/04/2019 | 31/03/2024 | £1,468,000 |
| MC_UU_00019/4 | Transfer | MC_UU_00019/3 | 01/04/2019 | 31/03/2024 | £843,000 |
| Title | Board to explain Vascular Ageing to the General Public |
| Description | This comic board was designed by Chloe Park and the VascAgeNet Public Engagement Team to explain the concepts of vascular ageing to the general public. |
| Type Of Art | Artwork |
| Year Produced | 2022 |
| Impact | This board is being used to educate the public on Vascular Ageing |
| URL | https://vascagenet.eu/public-engagement |
| Title | Vascular Ageing Illustration |
| Description | An illustration of Vascular Ageing, created by Chloe Park and the VascAgeNet Public Engagement Team |
| Type Of Art | Artwork |
| Year Produced | 2021 |
| Impact | This illustration explains the concepts of vascular ageing to the general public. |
| URL | https://vascagenet.eu/public-engagement |
| Description | Citations in Lancet Commission on Dementia |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Citation in other policy documents |
| Impact | The updated Commission report had a new section titled: "Physical illness, delirium, and dementia". My work contributed to the range of citations supporting that section. |
| URL | https://www.thelancet.com/article/S0140-6736(20)30367-6/fulltext |
| Description | First place in the Crick Innovation Challenge: Data-driven health |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Contribution to new or Improved professional practice |
| Impact | The tool could improve treatment outcoems in multimorbidity and save GP's time. |
| Description | Membership of NICE Delirium Guidelines update committee |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Currently open for consultation, but the committee have proposed a change to the methods by which delirium is assessed in all hospital and community settings. Delirium is prevalent in 1:4 older patients, so this will have a substantial impact on clinical practice. |
| URL | https://www.nice.org.uk/guidance/cg103/chapter/Update-information |
| Description | Membership of WHO's Clinical Consortium for Healthy Ageing |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | The Decade of Healthy Ageing 2020-30 is a wide programme of work consolidating work around (for example): - Integrated care for older people (ICOPE) - Integrated Continuum of Long-term Care - Universal Health Coverage and ageing - Research, evidence and data |
| URL | https://www.who.int/groups/clinical-consortium-on-healthy-ageing |
| Description | ARE THE IMPAIRMENTS OF ARGININE METABOLISM AS FOUND IN ALZHEIMER'S DISEASE ALSO PRESENT IN PATIENTS DEVELOPING POST-OPERATIVE DELIRIUM AND COGNITIVE DECLINE? |
| Amount | $329,769 (USD) |
| Funding ID | R21AG067083 |
| Organisation | National Institutes of Health (NIH) |
| Department | National Institute on Aging |
| Sector | Public |
| Country | United States |
| Start | 05/2020 |
| End | 04/2022 |
| Description | Biomedical follow-up of 1958 Birth Cohort Study members at age 60 |
| Amount | £1,544,004 (GBP) |
| Funding ID | MR/P023444/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2017 |
| End | 03/2022 |
| Description | Cohort and Longitudinal Studies Enhancement Resources (CLOSER) |
| Amount | £9,395,000 (GBP) |
| Funding ID | ES/K000357/1 |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2012 |
| End | 03/2022 |
| Description | Perioperative Investigation of Markers for Elevated Delirium (PRIMED) Risk |
| Amount | £173,905 (GBP) |
| Funding ID | RPGF1810/91 |
| Organisation | The Dunhill Medical Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2019 |
| End | 05/2021 |
| Description | Social Health And Reserve in the Dementia patient journey (SHARED) |
| Amount | £291,000 (GBP) |
| Funding ID | HESOCARE-329-109 |
| Organisation | Alzheimer's Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2019 |
| End | 12/2022 |
| Title | Covid 19 questionnaire |
| Description | A covid questionnaire was developed and sent to all NSHD study members. This was an online questionnaire about what the study members' lives have been like during the pandemic. The questionnaire covered the impact of the pandemic on work, health, family and social life. Three waves have been sent out. |
| Type Of Material | Biological samples |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Too early to say |
| Title | 1970 British Cohort Study Response Dataset, 1970-2016 |
| Description | The 1970 British Cohort Study (BCS70) began in 1970 when data were collected about the births and families of babies born in the United Kingdom in one particular week in 1970. Since then, there have been nine further full data collection exercises in order to monitor the cohort members' health, education, social and economic circumstances. These took place when respondents were aged 5 in 1975, aged 10 in 1980, aged 16 in 1986, aged 26 in 1996, aged 30 in 1999-2000 (SN 5558), aged 34 in 2004-2005, aged 42 in 2012 and aged 46 in 2016-18. A range of sub-sample and supplementary surveys have also been conducted, and a separate dataset covering response to BCS70 over all waves is available under SN 5641, 1970 British Cohort Study Response Dataset, 1970-2012. Further information about the BCS70 and may be found on the Centre for Longitudinal Studies website. As well as BCS70, the CLS now also conducts the NCDS series. How to access genetic and/or bio-medical sample data from a range of longitudinal surveys: A useful overview of the governance routes for applying for genetic and bio-medical sample data, which are not available through the UK Data Service, can be found at Governance of data and sample access on the METADAC (Managing Ethico-social, Technical and Administrative issues in Data Access) website. The BCS70 Response Dataset contains response outcomes for all main sweeps of BCS70 (1970-2016). The fourth edition (March 2021) includes Sweep 10 outcomes and has been streamlined by removing cases which have never participated in any main sweep survey and are no longer being issued. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | https://cls.ucl.ac.uk/cls-studies/1970-british-cohort-study/ |
| URL | https://beta.ukdataservice.ac.uk/datacatalogue/doi/?id=5641#2 |
| Title | Avon Longitudinal Study of Parents and Children |
| Description | ALSPAC is a longitudinal birth cohort study which enrolled pregnant women who were resident in one of three Bristol-based health districts in the former County of Avon with an expected delivery date between 1st April 1991 and 31st December 1992. Around 14,000 pregnant women were initially recruited. Detailed information has been collected on these women, their partners and subsequent children using self-completion questionnaires, data extraction from medical notes, linkage to routine information systems and from hands-on research clinics. Additional cohorts of participants have since been enrolled in their own right including fathers, siblings, children of the children and grandparents of the children. Ethical approval for the study was obtained from the ALSPAC Ethics and Law Committee (IRB00003312) and Local Research Ethics. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2014 |
| Provided To Others? | Yes |
| Impact | http://www.bristol.ac.uk/alspac/ |
| URL | http://service.re3data.org/repository/r3d100011256 |
| Title | Born in Bradford |
| Description | Born in Bradford is one of the biggest and most important medical research studies undertaken in the UK. The project started in 2007 and is looking to answer questions about our health by tracking the lives of 13,500 babies and their families and will provide information for studies across the UK and around the world. The aim of Born in Bradford is to find out more about the causes of childhood illness by studying children from all cultures and backgrounds as their lives unfold. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | https://borninbradford.nhs.uk/ |
| URL | http://service.re3data.org/repository/r3d100011818 |
| Title | Covid 19 questionnaire dataset |
| Description | NSHD study members were sent upto three online/postal questionnaires on COVID. In the first questionnaire, a variety of questions were asked to capture a physical and mental health and wellbeing, family and relationships, education, work, and finances during the first national lockdown. In the second questionnaire, we repeated many of the topic areas as in Wave 1, but included questions on health care, financial transfer and life events. For the third questionnaire, we additionally asked about the vaccination programme and long COVID. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Too early to say - numerous publications and impacts will be produced using these data in the future |
| URL | https://beta.ukdataservice.ac.uk/datacatalogue/studies/study?id=8732 |
| Title | English Longitudinal Study of Ageing: Waves 0-9, 1998-2019 |
| Description | The English Longitudinal Study of Ageing (ELSA) is a longitudinal survey of ageing and quality of life among older people that explores the dynamic relationships between health and functioning, social networks and participation, and economic position as people plan for, move into and progress beyond retirement. The main objectives of ELSA are to: construct waves of accessible and well-documented panel data; provide these data in a convenient and timely fashion to the scientific and policy research community; describe health trajectories, disability and healthy life expectancy in a representative sample of the English population aged 50 and over; examine the relationship between economic position and health; investigate the determinants of economic position in older age; describe the timing of retirement and post-retirement labour market activity; and understand the relationships between social support, household structure and the transfer of assets. Further information may be found on the ELSA project website, the Institute for Fiscal Studies: ELSA and Natcen Social Research: ELSA web pages. Health conditions research with ELSA - June 2021 The ELSA Data team have found some issues with historical data measuring health conditions. If you are intending to do any analysis looking at the following health conditions, then please contact elsadata@natcen.ac.uk for advice on how you should approach your analysis. The affected conditions are: eye conditions (glaucoma; diabetic eye disease; macular degeneration; cataract), CVD conditions (high blood pressure; angina; heart attack; Congestive Heart Failure; heart murmur; abnormal heart rhythm; diabetes; stroke; high cholesterol; other heart trouble) and chronic health conditions (chronic lung disease; asthma; arthritis; osteoporosis; cancer; Parkinson's Disease; emotional, nervous or psychiatric problems; Alzheimer's Disease; dementia; malignant blood disorder; multiple sclerosis or motor neurone disease). How to access genetic and/or bio-medical sample data from a range of longitudinal surveys: A useful overview of the governance routes for applying for genetic and bio-medical sample data, which are not available through the UK Data Service, can be found at Governance of data and sample access on the METADAC (Managing Ethico-social, Technical and Administrative issues in Data Access) web site. Harmonised dataset: The Harmonised dataset is originally compiled in Stata, and contains extra alphabetic missing value codes. An SPSS version is also deposited, but as SPSS does not accommodate alphabetic missing value codes in numeric variables, the codes have transferred as long numeric codes. While the missing values are fully labelled, users should be aware that only the Stata alphabetic codes are described in the documentation. Users who prefer to use the Stata version will need access to Stata SE/MP software, as the file contains over 2,047 variables (the limit for the standard Stata 'Intercooled' version). ELSA COVID-19 study: A separate ad-hoc study conducted with ELSA respondents, measuring the socio-economic effects/psychological impact of the lockdown on the aged 50+ population of England, is also available under SN 8688, English Longitudinal Study of Ageing COVID-19 Study. Wave 1 was first released on 30 September 2020. Latest edition of ELSA: For the 35th edition (July 2021), mortality variables Mortstat, Yrdeath, agedead2 and maincod have been removed from the index file at the depositor's request, due to finalised agreement with NHS Digital. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | https://www.ucl.ac.uk/epidemiology-health-care/research/behavioural-science-and-health/research/psychobiology/english-longitudinal-study-ageing-0 |
| URL | https://beta.ukdataservice.ac.uk/datacatalogue/doi/?id=5050#21 |
| Title | Geography and Longitudinal Data: Understanding Society The UK Household Longitudinal Study |
| Description | Understanding Society is the largest longitudinal study of its kind and provides crucial information for researchers and policymakers on the changes and stability of people's lives in the UK. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | https://www.understandingsociety.ac.uk/research/impact |
| URL | http://rgdoi.net/10.13140/RG.2.2.15806.54089 |
| Title | Github repository |
| Description | I have uploaded my scripts for my last papers, so that people can replicate the results of my stidies |
| Type Of Material | Computer model/algorithm |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | I have been contacted by many researchers over the last years asking for further clarifications as well as suggestions for their analysis |
| URL | https://github.com/mkatsoulis82 |
| Title | MRC NSHD 2013-2018 Data |
| Description | The MRC National Survey of Health and Development (NSHD) has informed UK health care, education and social policy for more than 50 years and is the oldest and longest running of the British birth cohort studies. Today, with study members in their seventies, the NSHD offers a unique opportunity to explore the long-term biological and social processes of ageing and how ageing is affected by factors acting across the whole of life. From an initial maternity survey of 5362 births recorded in England, Scotland and Wales during one week of March 1946, a socially stratified sample of singleton babies born to married parents was selected for follow-up. These participants have been studied over twenty times throughout their life. During their childhood, the main aim of the NSHD was to investigate how the environment at home and at school affected physical and mental development and educational attainment. During adulthood, the main aim was to investigate how childhood health and development and lifetime social circumstances affected their adult health and function and their change with age. Now, as participants have reached retirement, the research team is developing the NSHD into a life course study of ageing. Study members were asked to attend a clinic at age 60-64 for a range of assessments (or alternatively have a home visit). They were invited for a home visit at 69 years, updating information on health, lifestyle and life circumstances as well as obtaining repeat physical and cognitive measurements. Postal questionnaires were completed before the clinic and home visits. A subset of 500 study members are also being invited to participate in a Neuroscience sub-study. This publication covers data from the NSHD for the years 2013 to 2018. The cohort study is ongoing and further data collections are being added, while component data sets are separately referable. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | Data provided for linkage within UK LLC |
| URL | http://www.nshd.mrc.ac.uk/data/nshd-digital-object-identifiers/mrc-nshd-2013-2018-data/ |
| Title | Millennium Cohort Study |
| Description | Socio-emotional behaviours in early childhood, including self-regulation, emotional problems, and peer problems, have been shown to individually influence academic achievement in primary and secondary school. Environmental and demographic factors have also been shown to influence a child's academic development. The current study extends previous work to consider - concurrently, using structural equation modelling - a broader array of antecedents and measures of social-emotional development to understand their relative effects on academic outcomes. Parent-report data on a nationally representative sample of children (n = 17,035) at ages 3 and 5 years, and academic assessment at age 7, were drawn from the Millennium Cohort Study for longitudinal modelling. Results indicate the individual and collective contribution of socio-emotional, environmental, and demographic antecedents, expanding the current literature on predictors of child academic achievement in primary school. The results suggest that malleable factors in early childhood are important predictors of later academic success, and thus may be viable targets for intervention. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | https://cls.ucl.ac.uk/cls-studies/millennium-cohort-study/ |
| URL | http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/36952/version/1 |
| Title | National Child Development Study: Activity Histories, 1974-2013 |
| Description | The National Child Development Study (NCDS) originated in the Perinatal Mortality Survey (see SN 5565), which examined social and obstetric factors associated with still birth and infant mortality among over 17,000 babies born in Britain in one week in March 1958. Surviving members of this birth cohort have been surveyed on eight further occasions in order to monitor their changing health, education, social and economic circumstances - in 1965 at age 7, 1969 at age 11, 1974 at age 16 (the first three sweeps are also held under SN 5565), 1981 (age 23 - SN 5566), 1991 (age 33 - SN 5567), 1999/2000 (age 41/2 - SN 5578), 2004-2005 (age 46/47 - SN 5579), 2008-2009 (age 50 - SN 6137) and 2013 (age 55 - SN 7669). There have also been surveys of sub-samples of the cohort, the most recent occurring in 1995 (age 37), when a 10% representative sub-sample was assessed for difficulties with basic skills (SN 4992). Finally, during 2002-2004, 9,340 NCDS cohort members participated in a bio-medical survey, carried out by qualified nurses (SN 5594, available under more restrictive Special Licence access conditions; see catalogue record for details). The bio-medical survey did not cover any of the topics included in the 2004/2005 survey. Further NCDS data separate to the main surveys include a response and deaths dataset, parent migration studies, employment, activity and partnership histories, behavioural studies and essays - see the NCDS series page for details. Further information about the NCDS can be found on the Centre for Longitudinal Studies website. How to access genetic and/or bio-medical sample data from a range of longitudinal surveys: A useful overview of the governance routes for applying for genetic and bio-medical sample data, which are not available through the UK Data Service, can be found at Governance of data and sample access on the METADAC (Managing Ethico-social, Technical and Administrative issues in Data Access) website. The purpose of the National Child Development Study: Activity Histories, 1974-2013 was to merge all data on work and non-work activities in successive sweeps into one longitudinal dataset. Data on work and non-work activities lasting one month or more have been collected in all NCDS sweeps from sweep 4 (age 23) onwards. The focus of the questions asked at each sweep vary from: work activities engaged in since leaving school (sweep 4 aged 23); work and non-work activities engaged in since leaving school (sweep 5, aged 33); work and non-work activities engaged in since the last sweep (sweep 6, aged 42); work and non-work activities engaged in since the last sweep or aged 16 (sweep 7, aged 46) work and non-work activities engaged in since 2000, or 2004 if included in sweep 7 (sweep 8, aged 50), work and non-work activities engaged in since 2004, or 2008 if included in sweep 8 (sweep 9, aged 55). Therefore the activity histories will start from the time that the cohort member left school and continue until the interview date of the latest data sweep that each cohort member participated in. The lengths of the activity histories vary depending on the latest sweep that a cohort member was present at. The minimum activity history length recorded is 1 month and the maximum is 480 months (40 years). Gaps in the activity histories occur where a cohort member has not been present at all sweeps and/or where full activity data were not reported. An employment histories dataset was previously created (Ward, 2007). This work was undertaken as part of the Gender Network Project. The current work on NCDS activity histories builds on this previous activity history and incorporates various cleaning of the data. This previous employment history included data up to sweep 7 (2004) only, did not deal with any non-work activities and did not identify duplicate activities (i.e. where an activity was reported again in a later sweep). Latest Edition Information For the second edition (June 2016) the data and documentation were updated to include the latest NCDS wave, extending coverage to 2013. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | https://cls.ucl.ac.uk/cls-studies/1958-national-child-development-study/ |
| URL | https://beta.ukdataservice.ac.uk/datacatalogue/doi/?id=6942#3 |
| Title | SABRE |
| Description | a UK population-based comparison of cardiovascular disease and diabetes in people of European, South Asian and African Caribbean heritage |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | Currently, and in the past, supported many research studies aiding hundreds of publications around the world. |
| URL | https://portal.dementiasplatform.uk/CohortDirectory/Item?fingerPrintID=SABRE |
| Title | TwinsUK |
| Description | The TwinsUK resource is the biggest UK adult twin registry of 12.000 twins used to study the genetic and environmental aetiology of age related complex traits and diseases. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | https://twinsuk.ac.uk/media-and-engagement/overview/ |
| URL | http://service.re3data.org/repository/r3d100011851 |
| Description | CLOSER |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | N/A yet |
| Collaborator Contribution | N/A yet |
| Impact | N/A yet |
| Start Year | 2022 |
| Description | Network of Applied Statisticians in Health |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I started collaborating with other statisticians at UCL, with whom we share common interests in the statistical analysis of different types of health databases. I mainly help people who want to analyse Electronic Health Records. In 2022, I organised a short course on "Target Trial Emulation", that had more than 200 participants From March 2023, I have been one of the network leads the NASH network, see https://www.ucl.ac.uk/population-health-sciences/research/network-applied-statisticians-health |
| Collaborator Contribution | Their contribution was the useful feedback and comments that I had on my projects. |
| Impact | I am writing one paper, in which I received useful comments from 2 members of this team (Bianca de Stavola and Manuel Gomes), who will be included as co-authors. |
| Start Year | 2018 |
| Description | 75th birthday celebratory talk series |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | A series of five talks were orgnaised for the birthday week in March to celbrate 75 years of the NSHD. The topics covered were recent finding, future plans, covid research and cross cohort work, the history of the NSHD and archive and how the childhood questionnaires are being used in current research. The talks were live streamed from youtube and we had on average 100 peopl ewatching and lots of questions were asked throughout each session. |
| Year(s) Of Engagement Activity | 2021 |
| Description | British Science Week Social Media Campaign |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | This year the Unit ran a social media campaign during British Science Week to showcase the many 'connections' that the unit has. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Childhood adiposity and the heart |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation about the use of Mendelian randomization to understand the impact of childhood adiposity on heart structure and function in later life. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Ham and High article re Linkage Camden COVID substudy |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Ham and High article re Linkage Camden COVID substudy. Increased awareness of the new DELPHIC covid substudy. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Invited Talk: BIHS 2021 Resilience in Research |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Chloe Park gave an Invited Talk at the Young Investigators session of the BIHS meeting, Brighton, Sep 2021, on Resilience in Research |
| Year(s) Of Engagement Activity | 2021 |
| Description | Its all academic 2019 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | LHA took part in the UCL Its all academic festival. LHA had their Game of Life activity which was an interactive game where participants learnt about our longitudinal research into healthy ageing. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Keir Starmer MP Research visit |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Local MP, Sir Keir Starmer was invited to the MRC Festival of Medical Research but he was unable to attend. However, he offered to visit the units, who were taking part in the Festival. We and the MRC LMBC took up the opportunity to meet Keir. He met with staff, who explained about the cohort studies we have at the Unit - MRC NSHD, SABRE, LINKAGE and Insight 46 (a substudy of the MRC NSHD). |
| Year(s) Of Engagement Activity | 2019 |
| Description | LH&W and Convalescence Study conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | The first face-to-face LH&W and Convalescence Study conference took place on November 17th/18th at The Danubius Hotel Regents Park. ~90 researchers from 15 institutions attended and made the event a great success. LHA researchers featured throughout the conference, including presentations from Professor Nish Chaturvedi, Dr Kishan Patel, Dr Khaled Rjoob and Dr Wels Jacques. Thank you to Dr Alisia Carnemolla , Dr Dylan Williams and Dr Chloe Park for organising the event. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Local newspaper article on UCLH Covid work in older people |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with Ham and High, North London newspaper, covering findings in recent European Geriatric Medicine publication. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.hamhigh.co.uk/news/health/21348110.camden-coronavirus-study-yields-surprising-results/ |
| Description | MRC Festival June 2019 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | LHA hosted a Science Fair at UCL with the MRC Laboratory for Medical Cell Biology and the MRC Prion. This was a free family fun day for all ages and included hands-on activities, interactive demonstrations, games and exhibitions. LHA had their Game of Life activity which was an interactive game where participants learnt about our longitudinal research into healthy ageing. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Media interest in Respiratory paper |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | This paper was picked up by a number of media outlets - Early childhood lower respiratory tract infection and premature adult death from respiratory disease in Great Britain: a national birth cohort study |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.ucl.ac.uk/news/headlines/2023/mar/respiratory-disease-childhood-linked-premature-death-a... |
| Description | Member of the International Society for Clinical Biostatistics (Education committee) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | I have been a member of the ISCB committee for 2 years. Our goal is to support and organise educational activities, such as short-courses, webinars and seminars on contemporary methods in clinical biostatistics |
| Year(s) Of Engagement Activity | 2021,2022,2023 |
| URL | https://iscb.info/education/ |
| Description | NSHD 76th Birthday Pack |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Study participants or study members |
| Results and Impact | We sent a birthday card and newsletter to the NSHD study members |
| Year(s) Of Engagement Activity | 2022 |
| Description | NSHD Advisory Panel |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | We have 2 NSHD Advisory Panels. A discussion group with 12 study members and a email/postal group with 24 study members. We aim to hold 2 meetings of the discussion group per year. We send out information to the email/postal group as and when we have questions we would like to ask the study members. |
| Year(s) Of Engagement Activity | 2022,2023 |
| Description | NSHD Study Members Birthday Pack |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Study participants or study members |
| Results and Impact | Every year for the study member's birthday we send them out a birthday card and newsletter |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://nshd.mrc.ac.uk/newsletter-2023/ |
| Description | Non communicable diseaes in South Asia Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | NCD in South Asia Workshop 23rd to 24th Jan 2020. Led by Academy of Medical Sciences. Steering committee member, chair and facilitator. Bringing regional experts in NCDs together to discuss research state, gaps, and initiatives. Following the workshop, a written report is being produced and will be disseminated to stakeholders within the region and the UK highlighting the identified next steps to help tackle NCDs South Asia. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Podcast about Delirium |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Podcast using content funded by the British Podcast Awards and the Wellcome Trust. Dr Daniel Davis speaks about the work he is doing looking at how delirium and dementia impact society and health at a population level. Raised awareness of Delirium and the DELPHIC research study. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Press Release - role of cognitive reserve markers from NSHD |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Paper picked up for a press release programme |
| Year(s) Of Engagement Activity | 2022 |
| Description | Research featured in Growing Older, Better Physiology's role in meeting the UK Government's healthy ageing mission by The Physiological Society |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Dan Davis research was featured in this report to highlight the need for close and constant collaboration between the research and clinical communities to provide a feedback loop to ensure the latest research is always informing clinical actions related to healthy ageing and lifelong health. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://static.physoc.org/app/uploads/2019/10/11135853/Growing-old-better-Full-report-and-summary-do... |
| Description | Science Museum Lates 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | LHA took their Life Course Golf Course activity to the Science Museum Lates. Participants were taken round the miniature golf course by our researchers (the caddy) and learnt about our longitudinal research into healthy ageing |
| Year(s) Of Engagement Activity | 2019 |
| Description | Student attends 146th Executive Board Meeting of the World Health Organization |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Student attended 146th Executive Board Meeting of the World Health Organization in Geneva from Feb. 3rd-8th as a delegate of the International Federation of Medical Students' Associations (IFMSA). As part of the Non-Communicable Diseases Advocacy Working Group, presented written and oral statements on several topics, including Maternal, Infant and Young Child Nutrition; the 3rd UN HLM on NCDs; and the proposal for the Decade of Health Ageing. |
| Year(s) Of Engagement Activity | 2020 |