Mechanisms in Disorders of Energy Balance

Lead Research Organisation: University of Cambridge

Abstract

We aim to understand the biological processes controlling what we eat and how we store and use energy. These pathways are disturbed in obesity and related metabolic conditions such as Type 2 diabetes, and this knowledge will, ultimately, lead to development of new treatments for these disorders.

We know that an individual’s genetic make up plays a significant role in determining their susceptibility to developing obesity and its deleterious consequences. Recent scientific and technological advances have made it substantially easier to analyse human genetic code. We aim to exploit data from human genetic studies to gain fundamental insights into what causes human obesity, and propose to combine these genetic studies with laboratory studies based around cell lines and whole animal models to better understand the pathways involved.

This programme builds upon our previous work centred around a large group of patients from around the world who developed severe obesity as children and who have formed the basis for subsequent detailed studies on food intake and energy use. While humans will always be our experimental subject of choice, there are important questions regarding mechanism which require alternative approaches. In particular, we plan to use rodent models to explore aspects of disease processes that cannot be readily addressed in humans. Further, rodents have the advantage of being readily susceptible to genetic manipulation allowing precise alteration of specific genes and, importantly, the creation of animal models of relevant, specific, human diseases.

Technical Summary

Obesity and its metabolic consequences are major threats to public health with an unmet need for improved therapy and prevention. Understanding the mechanisms involved in the control of human energy balance is essential to develop new treatments.
By focusing upon a cohort of patients with severe early onset obesity, we have uncovered novel, highly penetrant alleles causing childhood obesity and gone on to establish the mechanisms of molecular dysfunction in many of these conditions. More recently, new and important insights into the genetic basis of common obesity are beginning to emerge from hypothesis-free genome-wide approaches. There is, at present, an important gap between the identification of an allele as being unequivocally associated with an adiposity phenotype and understanding how that allele actually influences energy balance. Building upon our established expertise, we aim to use a range of research methodologies to close that gap and turn statistical association into a deeper understanding of biology. This includes, when necessary and appropriate, the use of model organisms. While humans will always be our experimental subject of choice, and while advances in technology increasingly allow us to undertake more sophisticated non-invasive studies in humans, there are important questions regarding physiology and pathophysiology that require the use of animal studies. For example, as the hypothalamus is a key centre for energy and metabolic regulation, animal studies provide the only way in which direct and meaningful manipulation of hypothalamic function can be undertaken.
This programme will include the in vitro study of the biochemical properties of variant molecules as well as studies in heterologously expressing mutant genes to determine the biological consequences of genetic variants at a cellular level. This work will both inform and be influenced by on–going in vivo studies utilising mouse models of novel human genetic diseases. The phenotypic evaluation of such mice will be comprehensive, not only including studies of body composition, energy balance and intermediary metabolism but also involving increasingly sophisticated behavioural analysis. We will feed back the information from these studios into relevant clinical programmes, particularly those of Farooqi and Wareham (MRC Epidemiology Unit) where findings in the miceshould inform further targeted evaluation of human phenotypes.

Organisations

Publications

10 25 50

publication icon
Carr SK (2014) Maternal diet amplifies the hepatic aging trajectory of Cidea in male mice and leads to the development of fatty liver. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology

publication icon
Challis BG (2015) Heterogeneity of glucagonomas due to differential processing of proglucagon-derived peptides. in Endocrinology, diabetes & metabolism case reports

publication icon
Cheung MK (2013) FTO expression is regulated by availability of essential amino acids. in International journal of obesity (2005)

publication icon
Cimino I (2017) GDF15 and energy balance: homing in on a mechanism. in Nature medicine

publication icon
Coll AP (2013) "Are melanocortin receptors constitutively active in vivo?". in European journal of pharmacology

 
Description MRC Workshop on Neuroscience of Obesity: Gut-brain communication
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description SOR Parliamentary report on sugar (acted as expert health professional in telephone interview)
Geographic Reach Australia 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
 
Description A glucose-responsive network
Amount £609,000 (GBP)
Funding ID MR/R002991/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2017 
End 09/2020
 
Description Consequences of targeted SNORD116 deletion in human and mouse neurons
Amount $64,799 (USD)
Organisation Foundation for Prader-Willi Research (FPWR) 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2018 
End 03/2019
 
Description Recapitulating obesity and hyperphagia in novel adult-onset mouse models of Snord116 deletion
Amount $87,600 (USD)
Organisation Foundation for Prader-Willi Research (FPWR) 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2016 
End 09/2017
 
Description EurOCHIP 
Organisation Cochin Institute
Department INSERM U1016
Country France 
Sector Academic/University 
PI Contribution Coordinator
Collaborator Contribution European Obesity Consortium studying the Hypothalamus and its Interaction with the Periphery
Impact European Obesity Consortium studying the Hypothalamus and its Interaction with the Periphery
Start Year 2009
 
Description EurOCHIP 
Organisation Helmholtz Zentrum München
Department Institute for Diabetes and Obesity
Country Germany 
Sector Public 
PI Contribution Coordinator
Collaborator Contribution European Obesity Consortium studying the Hypothalamus and its Interaction with the Periphery
Impact European Obesity Consortium studying the Hypothalamus and its Interaction with the Periphery
Start Year 2009
 
Description EurOCHIP 
Organisation Imperial College London
Department Division of Diabetes, Endocrinology & Metabolism
Country United Kingdom 
Sector Academic/University 
PI Contribution Coordinator
Collaborator Contribution European Obesity Consortium studying the Hypothalamus and its Interaction with the Periphery
Impact European Obesity Consortium studying the Hypothalamus and its Interaction with the Periphery
Start Year 2009
 
Description EurOCHIP 
Organisation Max Planck Society
Department Max Planck Institute for Neurological Research
Country Germany 
Sector Public 
PI Contribution Coordinator
Collaborator Contribution European Obesity Consortium studying the Hypothalamus and its Interaction with the Periphery
Impact European Obesity Consortium studying the Hypothalamus and its Interaction with the Periphery
Start Year 2009
 
Description EurOCHIP 
Organisation Pasteur Institute, Lille
Country France 
Sector Charity/Non Profit 
PI Contribution Coordinator
Collaborator Contribution European Obesity Consortium studying the Hypothalamus and its Interaction with the Periphery
Impact European Obesity Consortium studying the Hypothalamus and its Interaction with the Periphery
Start Year 2009
 
Description EurOCHIP 
Organisation University of Gothenburg
Department Sahlgrenska Academy
Country Sweden 
Sector Academic/University 
PI Contribution Coordinator
Collaborator Contribution European Obesity Consortium studying the Hypothalamus and its Interaction with the Periphery
Impact European Obesity Consortium studying the Hypothalamus and its Interaction with the Periphery
Start Year 2009
 
Description Full4health 
Organisation Harokopio University
Country Greece 
Sector Academic/University 
PI Contribution Partner
Collaborator Contribution Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health
Impact Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health
Start Year 2011
 
Description Full4health 
Organisation Maastricht University (UM)
Department School for Nutrition, Toxicology and Metabolism (NUTRIM)
Country Netherlands 
Sector Academic/University 
PI Contribution Partner
Collaborator Contribution Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health
Impact Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health
Start Year 2011
 
Description Full4health 
Organisation Max Planck Society
Department Max Planck Institute for Neurological Research
Country Germany 
Sector Public 
PI Contribution Partner
Collaborator Contribution Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health
Impact Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health
Start Year 2011
 
Description Full4health 
Organisation National Institute of Health and Medical Research (INSERM)
Department Inserm U837 UMR-S 1172 Jean Pierre Aubert Research Centre
Country France 
Sector Public 
PI Contribution Partner
Collaborator Contribution Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health
Impact Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health
Start Year 2011
 
Description Full4health 
Organisation Norwegian University of Science and Technology (NTNU)
Country Norway 
Sector Academic/University 
PI Contribution Partner
Collaborator Contribution Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health
Impact Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health
Start Year 2011
 
Description Full4health 
Organisation University of Aberdeen
Department Rowett Institute of Nutrition and Health Aberdeen
Country United Kingdom 
Sector Academic/University 
PI Contribution Partner
Collaborator Contribution Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health
Impact Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health
Start Year 2011
 
Description Full4health 
Organisation University of Copenhagen
Country Denmark 
Sector Academic/University 
PI Contribution Partner
Collaborator Contribution Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health
Impact Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health
Start Year 2011
 
Description Full4health 
Organisation University of Edinburgh
Department Centre for Integrative Physiology
Country United Kingdom 
Sector Academic/University 
PI Contribution Partner
Collaborator Contribution Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health
Impact Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health
Start Year 2011
 
Description Full4health 
Organisation University of Gothenburg
Department Sahlgrenska Academy
Country Sweden 
Sector Academic/University 
PI Contribution Partner
Collaborator Contribution Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health
Impact Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health
Start Year 2011
 
Description Full4health 
Organisation University of Leeds
Country United Kingdom 
Sector Academic/University 
PI Contribution Partner
Collaborator Contribution Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health
Impact Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health
Start Year 2011
 
Description Full4health 
Organisation University of Wageningen
Department Division of Human Nutrition
Country Netherlands 
Sector Academic/University 
PI Contribution Partner
Collaborator Contribution Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health
Impact Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health
Start Year 2011
 
Description Full4health 
Organisation Utrecht University
Department Rudolf Magnus Institute
Country Netherlands 
Sector Academic/University 
PI Contribution Partner
Collaborator Contribution Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health
Impact Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health
Start Year 2011
 
Description ICEMED 
Organisation Charité - University of Medicine Berlin
Department Paediatric and Adolescent Medicine
Country Germany 
Sector Hospitals 
PI Contribution Partner
Collaborator Contribution Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Impact Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Start Year 2012
 
Description ICEMED 
Organisation German Cancer Research Center
Country Germany 
Sector Public 
PI Contribution Partner
Collaborator Contribution Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Impact Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Start Year 2012
 
Description ICEMED 
Organisation Heinrich Heine University Düsseldorf
Country Germany 
Sector Academic/University 
PI Contribution Partner
Collaborator Contribution Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Impact Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Start Year 2012
 
Description ICEMED 
Organisation Helmholtz Association of German Research Centres
Department The Max Delbrück Center for Molecular Medicine (MDC)
Country Germany 
Sector Academic/University 
PI Contribution Partner
Collaborator Contribution Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Impact Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Start Year 2012
 
Description ICEMED 
Organisation Helmholtz Zentrum München
Department Institute of Stem Cell Research
Country Germany 
Sector Charity/Non Profit 
PI Contribution Partner
Collaborator Contribution Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Impact Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Start Year 2012
 
Description ICEMED 
Organisation Julich Research Centre
Country Germany 
Sector Public 
PI Contribution Partner
Collaborator Contribution Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Impact Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Start Year 2012
 
Description ICEMED 
Organisation Max Planck Society
Department Max Planck Institute for Neurological Research
Country Germany 
Sector Public 
PI Contribution Partner
Collaborator Contribution Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Impact Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Start Year 2012
 
Description ICEMED 
Organisation RWTH Aachen University
Country Germany 
Sector Academic/University 
PI Contribution Partner
Collaborator Contribution Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Impact Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Start Year 2012
 
Description ICEMED 
Organisation University Clinic Dresden
Country Germany 
Sector Hospitals 
PI Contribution Partner
Collaborator Contribution Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Impact Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Start Year 2012
 
Description ICEMED 
Organisation University Clinic Lubeck
Country Germany 
Sector Hospitals 
PI Contribution Partner
Collaborator Contribution Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Impact Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Start Year 2012
 
Description ICEMED 
Organisation University Duisburg-Essen
Department Faculty of Medicine
Country Germany 
Sector Academic/University 
PI Contribution Partner
Collaborator Contribution Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Impact Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Start Year 2012
 
Description ICEMED 
Organisation University Hospital Tuebingen
Country Germany 
Sector Hospitals 
PI Contribution Partner
Collaborator Contribution Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Impact Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Start Year 2012
 
Description ICEMED 
Organisation University Medical Center Freiburg
Department Department of Radiology
Country Germany 
Sector Hospitals 
PI Contribution Partner
Collaborator Contribution Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Impact Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Start Year 2012
 
Description ICEMED 
Organisation University of Leipzig
Country Germany 
Sector Academic/University 
PI Contribution Partner
Collaborator Contribution Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Impact Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Start Year 2012
 
Description ICEMED 
Organisation Yale University
Department School of Medicine
Country United States 
Sector Academic/University 
PI Contribution Partner
Collaborator Contribution Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Impact Imaging and Curing Environmental Metabolic Diseases' Consortium award amount
Start Year 2012
 
Description Macrophages and lipotoxicity. 
Organisation Spanish Ministry of Health and Consumer Affairs
Department National Center for Cardiovascular Research (CNIC)
Country Spain 
Sector Public 
PI Contribution ongoing intellectual and experimental collaboration
Collaborator Contribution access to facilities and expertise not otherwise available
Impact publication in preparation
Start Year 2007
 
Description characterisation of a novel model of obesity involving a paternally expressed gene 
Organisation Max Planck Society
Department Max Planck Institute of Immunobiology and Epigenetics
Country Germany 
Sector Public 
PI Contribution collaboration on a novel model of obesity involving imprinted paternally expressed genes detailed phenotyping of mouse model
Collaborator Contribution intellectual guidance, mouse resources
Impact publication currently being written
Start Year 2013
 
Description collaboration to study a novel model of obesity and developmental delay 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution just beginning this collaboration after frutiful discussion around imprinted genes and obesity
Collaborator Contribution generation and phenotyping of this mouse model
Impact no output yet
Start Year 2016
 
Description description of novel role for gut peptide Insl5 
Organisation Takeda Cambridge Ltd
Country United Kingdom 
Sector Private 
PI Contribution undertook in vivo studies of action of peptide on food intake
Collaborator Contribution generation of murine models and parallel physiological studies of role of peptide
Impact publication in PNAS- ( Grosse et al, 2014, PMID: 25028498)
Start Year 2007
 
Description development of a model of metabolic consequences of glucocorticoid therapy 
Organisation University of Manchester
Department Division of Cell Matrix Biology and Regenerative Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution intellectual input, murine reagents, technical expertise
Collaborator Contribution murine models, manpower, technical expertise, intellectual input
Impact Manuscript published in Endocrinology , Nov 2016 (Harno et al, PMID: 27649090)
Start Year 2014
 
Description generation and characterisation of novel mouse model of MRAP2 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution undertook detailed phenotyping of energy expenditure of mouse model
Collaborator Contribution mouse developed using technology available at Sanger
Impact generation of a mouse model,
Start Year 2012
 
Description 'ARE YOUR GENES TO BLAME WHEN YOUR JEANS DON'T FIT?' Talk at the Hay Festival 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact ARE YOUR GENES TO BLAME WHEN YOUR JEANS DON'T FIT?, talk at the Hay Festival 2016 as part of the Cambridge series.
Year(s) Of Engagement Activity 2016
URL https://www.hayfestival.com/p-11106-giles-yeo.aspx
 
Description 'If your jeans don't fit, maybe your genes don't fit?' - Authored piece for the Sunday Times, Jan 12th 2015 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact This authored piece in the 'Review' section of the Sunday Times was written in support of the BBC2 release of 'What's the right diet for you?', in which I was one of the scientific experts.
Year(s) Of Engagement Activity 2015
URL http://www.thesundaytimes.co.uk/sto/newsreview/features/article1505198.ece
 
Description 'Role of FTO as a brain nutrient sensor' - Invited symposium speaker at the American Diabetes Association annual meeting in New Orleans, 10/6/16 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 'Role of FTO as a brain nutrient sensor' - Invited symposium speaker at the American Diabetes Association annual meeting in New Orleans, 10/6/16
Year(s) Of Engagement Activity 2016
 
Description 2015 Keynote Speaker Foundation of European Nurses in Diabetes Annual Meeting, Stockholm, Sweden, September 12th 2015. Title 'Genomics in Obesity Management' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 200 diabetic nurses attended, which is not normally who I speak to. This sparked interesting discussions
Year(s) Of Engagement Activity 2015
 
Description Abcam meeting, Fitzwilliam ,Cambridge 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact "Melanocortins and beyond
- the hypothalamic control of energy balance" AP Coll

Programming Obesity:
Central and Peripheral Contributors

April 14-16, 2013
Fitzwilliam College, University of Cambridge


useful post presentation discussion with peers on how to take evolving data forward
Year(s) Of Engagement Activity 2013
 
Description Appearance on Radio 4's 'Start the week' with Andrew Marr on 6/6/16 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Appeared on R4's 'Start the week' with Andrew Marr, discussing Genes and Inheritance.
Year(s) Of Engagement Activity 2016
URL http://www.bbc.co.uk/programmes/b07dkk09
 
Description Authored piece in the DailyMail on the utility of commercial genetic tests in predicting disease 'Should you take a gene test to tell if you will put on weight? Don't waste your cash' 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact This authored piece in the DailyMail (which I only agreed to because it was authored) generated quite a bit of public interest on twitter
Year(s) Of Engagement Activity 2015
URL http://www.dailymail.co.uk/health/article-2987372/Should-gene-test-tell-weight-Don-t-waste-cash.html
 
Description BBC Four documentary 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Filmed and interviewed for BBC Four documentary on the history of how we came to understand hormones, specifically regarding work on leptin.

N/A - documentary is yet to air.
Year(s) Of Engagement Activity 2013
 
Description BBC Radio Cambridgeshire interview (Apr 2013) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Raised awareness of obesity and genetics.
Year(s) Of Engagement Activity 2013
 
Description Cambridge Science Festival - 'Starch, Milk and Alcohol' 11th March 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact This is a lecture at the Annual Cambridge Science Festival, which is the biggest 'free to attend' Science festival of its kind in the UK
Year(s) Of Engagement Activity 2016
URL https://www.eventbrite.co.uk/e/starch-milk-and-alcohol-tickets-19842258730
 
Description Diet and Genes: Can we pass on our sins? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact We held a 'question time' type panel discussion and debate about the genetics and epigenetics of obesity.
Year(s) Of Engagement Activity 2019
URL http://www.metabolism.cam.ac.uk/event/diet-and-genes-can-we-pass-on-our-sins/
 
Description Expert contributor, Fat Family Tree, Channel 4 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Channel 4 documentary on genetics of obesity, aired on 23rd May, 2013

Increasing public awareness of genetics of obesity
Year(s) Of Engagement Activity 2013
URL http://www.channel4.com/programmes/fat-family-tree/episode-guide
 
Description Interview on Real Nutrition Radio - Are gene tests worth it? 8th June 2015 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This interview dealt with the utility of genetic testing in so-called 'nutri-genomics'....punch line, it will happen one day perhaps, but not yet!
Year(s) Of Engagement Activity 2015
URL http://www.realnutritionradio.com/podcast/ep17-are-genetic-tests-worth-it-with-giles-yeo/
 
Description Interview on The Kim Hill show, on New Zealand National Radio, Sep 5th 2015 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact This was a 45 min interview about obesity on New Zealand National Radio with Kim Hill, the doyenne of NZ talk radio.
Year(s) Of Engagement Activity 2015
URL http://omnyapp.com/shows/rnz-saturday-morning/giles-yeo-obesity-and-genetics
 
Description Interview with the Naked Scientists Radio Show, ' Why are people prone to gaining weight?' Jan 12th 2015, 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The initial show when out live on BBC radio cambridgeshire. The podcast of this then was released internationally. Lots of twitter comments and feedback.
Year(s) Of Engagement Activity 2015
URL http://www.thenakedscientists.com/HTML/interviews/interview/1001083/
 
Description MRC Centenary Exhibition 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Type Of Presentation Poster Presentation
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact as part of MRC centenary, our laboratory space was open to the public. Across an afternoon over 60 people came on guided tour of the lab, with manned poster stations highlighting research activity

great deal of interest from a number of 6th formers who wish to try and return to the lab as summer visitors
Year(s) Of Engagement Activity 2013
 
Description Participating in 'Britain's Fat Fight' with chef, author and broadcaster Hugh Fearnley Whittingstall 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The heart of this programme was the effort to get a city in the UK, Newcastle, to lose 100,000 pounds. But clearly all the lessons learnt are broadly applicable across the UK and internationally. It was a three part series and I had a role in all three episodes. The first episode had me helping Hugh place the obesity problem into context. But it was the following two episodes which saw me going to Newcastle to try and engender real change on the ground. First I was given access to the central Newcastle metro station, where I placed footsteps leading from the platform and up the stairs, in order to try and 'nudge' commuters to use the stairs instead of the escalators. In the short-term, we did manage to get significantly more people using the stairs. Then I was given access to a street in Newcastle with a number of takeaway establishments. Here I manage to get them to swap out 'full-sugar' ketchup for the low sugar option (after a taste test to demonstrate that no one would be able to tell the difference), play about with portion sizes, as well as move full sugar beverages away from eye and grab height. What happened after the cameras left? Well, I went back to give a talk in Newcastle end of 2018 (the programmes had aired May 2018), I found that those footsteps that I had only put up at the central Metro station had now spread all across the city! In other stations, as well as in council owned buildings.
Year(s) Of Engagement Activity 2018
URL https://www.bbc.co.uk/programmes/b0b0y27w
 
Description Presentation in the BBC Science Zone, at the 2015 Cheltenham Science Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact This appearance at the Cheltenham Science Festival was a real experience. But the real benefit to me was I ended up being recruited to present my own BBC Horizon documentary!
Year(s) Of Engagement Activity 2015
 
Description Presented 'Clean eating - The dirty truth' for BBC2 Horizon, aired 19/1/17 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Presented 'Clean eating - The dirty truth' for BBC2 Horizon, aired 19/1/17
Year(s) Of Engagement Activity 2017
URL http://www.bbc.co.uk/programmes/b08bhd29
 
Description Presented 'Why are we getting so fat?', a BBC2 Horizon Documentary, aired 7/6/16 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact I presented 'Why are we getting so fat' for BBC2 Horizon, which transmitted on 7/6/16. Viewing figures were 2 million in the UK. Has been aired now all over the world.
Year(s) Of Engagement Activity 2016
URL http://www.bbc.co.uk/programmes/b07fys2y
 
Description Press release for Cell article (Oct 2013) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Raised awareness of obesity and genetics.
Year(s) Of Engagement Activity 2013
URL http://www.cell.com/abstract/S0092-8674(13)01276-2
 
Description Press release for Nature Genetics article (Aug 2013) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Raised awareness of obesity and genetics.
Year(s) Of Engagement Activity 2013
URL http://www.nature.com/ng/journal/v45/n9/full/ng.2716.html
 
Description Press release for Science paper (July 2013) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Raised awareness of obesity and genetics.
Year(s) Of Engagement Activity 2013
URL http://www.sciencemag.org/content/341/6143/275.full
 
Description Radio interview with Heart FM (Apr 2013) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Raised awareness of obesity and genetics.
Year(s) Of Engagement Activity 2013
 
Description SOR - Academy of Medical Sciences Fellows Event 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other audiences
Results and Impact Invited by Regional Champion of Academy of Medical Sciences to give keynote lecture at Fellows' event which was combined with THIS (The Healthcare Improvement Studies) Institute in Cambridge. The event was an opportunity for early and mid career researchers to present their work and to network with the fellows and peers and bring the East Anglia fellows together.
Year(s) Of Engagement Activity 2018
 
Description SOR - Cardiometabolic early careers researchers event, Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Invited keynote speaker at Cambridge Cardio-metabolic early careers researchers event at St Catharine's College, Cambridge. The event is aimed at encouraging collaboration and connectivity and is a joint meeting between the Cambridge Cardiovascular Strategic Research Initiative and the Cambridge Metabolic Network and will support integrative cardiometabolic science through sessions to showcase collaboration across the research themes. There will also be sessions to help participants form new connections through mutual interest in techniques and discussions around their research connections.
Year(s) Of Engagement Activity 2017
 
Description SOR - Cell Symposium, San Diego 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited speaker at Cell Symposium
Year(s) Of Engagement Activity 2017
URL http://www.cell-symposia.com/metabolic-therapies-2017/conference-program.asp
 
Description SOR - Dept of Vet Medicine Research afternoon 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact University of Cambridge Department of Veterinary Medicine Research afternoon
Year(s) Of Engagement Activity 2017
 
Description SOR - EMBO Basel Life mtg, Switzerland 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited to speak at EMBO Basel Life meeting on "Molecules in Biology and Medicine". A new EMBO meeting which is intended to combine general and medical biology. This meeting is a joint initiative of EMBO and a newly founded, not-for-profit organization, the European Association for Life Sciences. The scientific advisory committee envisions a top level, broad scope meeting and aims to establish it as one of the premier meetings in the life sciences. The meeting was held in conjunction with Basel Life Science Week.
Year(s) Of Engagement Activity 2018
 
Description SOR - Faulkner Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited to give the annual John A Faulkner lectureship at the University of Michigan.
Year(s) Of Engagement Activity 2017
URL https://medicine.umich.edu/dept/molecular-integrative-physiology/events/201710/faulkner-lecture-prof...
 
Description SOR - Helmholtz conference, Munich (2018) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Plenary speaker at 6th annual Helmholtz Diabetes Conference, Munich. Helmholtz Zentrum München and Nature Medicine have combined forces to organize this annual high-impact conference series now for the sixth time. At this meeting, international top scientists interact to facilitate the identification of, and potential solutions to, the preeminent scientific challenges facing the prevention and treatment of diabetes. For this 6th conference, the main focus will be on the role of the brain in metabolic control.
Year(s) Of Engagement Activity 2018
URL https://www.hd-conference.com/about-the-conference/index.html
 
Description SOR - ICE Cape Town 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Plenary speaker at International Congress of Endocrinology (ICE), Cape Town, South Africa which was held in conjunction with SEMDSA, the Society for Endocrinology,  Metabolism and Diabetes of Southern Africa. ICE is the premier global scientific gathering for endocrinology.
Year(s) Of Engagement Activity 2018
URL http://www.ice2018.org/
 
Description SOR - IFSO World Congress, London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Gave a talk at Best of British Symposium at IFSO (International Federation for the Surgery of Obesity and Metabolic Disorders) World Congress held in London
Year(s) Of Engagement Activity 2017
URL http://www.ifso2017.com/
 
Description SOR - Italian Debate for Endocrinology Experts (IDEE), Rome 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Invited to give plenary lecture given involvement with 100K Genomes UK project at "Italian Debate for Endocrinology Experts 2018" meeting in Rome for Italian delegates. All speakers international.
Year(s) Of Engagement Activity 2018
 
Description SOR - Keynote lecture at GVS 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact The Gynaecological Visiting Society of Great Britain and Ireland's 2017 Meeting in Cambridge which is a meeting of senior academics in Obstetrics and Gynaecology in the UK.
Year(s) Of Engagement Activity 2017
 
Description SOR - Keystone mtg, Copenhagen 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Keystone meeting: Neuronal control of appetite, metabolism and weight
Year(s) Of Engagement Activity 2017
URL http://keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1458
 
Description SOR - King's College DNS Postgrad Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other audiences
Results and Impact Gave talk at King's College London DNS (Departments of Diabetes and Nutritional Sciences) Postgraduate Symposium
Year(s) Of Engagement Activity 2017
 
Description SOR - MTB Zurich 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Invited as keynote speaker to give a talk at the annual retreat of the PhD Programme in Molecular and Translational Biomedicine (MTB), University of Zurich, Switzerland
Year(s) Of Engagement Activity 2018
 
Description SOR - Manchester Literary and Philosophical Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Invited by Science and Technology Committee of the The Manchester Literary and Philosophical Society, which was founded in 1781, to give a talk.
Year(s) Of Engagement Activity 2018
URL http://www.manlitphil.ac.uk
 
Description SOR - Medical Alumni Biennial Lecture, St Andrews 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Invited guest speaker at Medical Alumni Biennial Lecture at University of St Andrews, Fife
Year(s) Of Engagement Activity 2018
 
Description SOR - Milner Therapeutics Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Invited speaker at Milner Therapeutics Symposium which is a one day event, with speakers from Academia and Pharma/Biotech.
#MilnerSymp18
Year(s) Of Engagement Activity 2018
 
Description SOR - NIH OxCam Workshop, Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Invited to give keynote talk at the annual NIH OxCam Workshop held at Homerton College, Cambridge - a 3 day meeting that brings together supervisors and students from the NIH-OxCam PhD programme.
Year(s) Of Engagement Activity 2018
 
Description SOR - Oxford Metabolic Health symposium, Oxford 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Invited to give keynote talk at Oxford Metabolic Health's inaugural symposium - a new cross-divisional and interdepartmental initiative at the University of Oxford that aims to bring together researchers with an interest in metabolism in its broadest sense, encourage interaction and exchange of ideas, and identify new strategic opportunities.
Year(s) Of Engagement Activity 2018
 
Description SOR - Pembroke College Campaign Launch 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Talk given by fellows of Pembroke College for its Campaign Launch
Year(s) Of Engagement Activity 2017
 
Description SOR - Pembroke College Campaign event 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Pembroke College Campaign event held at the Royal Society in London
Year(s) Of Engagement Activity 2017
 
Description SOR - RIA Masterclass and discourse 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact As newly appointed honorary member of Royal Irish Academy, invited to give masterclass and Academy discourse
Year(s) Of Engagement Activity 2017
 
Description SOR - Rare Diseases MP visit 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Policymakers/politicians
Results and Impact Visit by Cambridge MP as part of International Rare Disease Day celebrations, including informal roundtable discussion on rare diseases with researcher community and patients
Year(s) Of Engagement Activity 2017
 
Description SOR - SGC TEP Symposium, Oxford 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited to give keynote lecture at SGC (Structural Genomics Consortium) University of Oxford TEP 2018 Symposium on 'Exploiting disease genomics to catalyse new medicines'- serving as an opportunity to bring together collaborators, funders, and partners alike to share the vision of the TEP concept for drug discovery.
Year(s) Of Engagement Activity 2018
URL https://www.thesgc.org/tep-symposium-2018
 
Description SOR - SpR training, Addenbrooke's Hospital 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Talk for Regional SpR diabetes and endocrine training day, Addenbrooke's Hospital, Cambridge
Year(s) Of Engagement Activity 2018
 
Description SOR - Sri Lanka College of Endocrine 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Three talks in two days given during Sri Lanka College of Endocrine 2017 meeting in Colombo
Year(s) Of Engagement Activity 2017
URL https://ecsl2017.com/download/ecsl-2017-flyer-programme.pdf
 
Description SOR - Swedish Diabetes Summit 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited speaker at 2nd Swedish Diabetes Summit held at Gothenburg which was jointly organised by the Sahlgrenska Academy of Gothenburg University and AstraZeneca
Year(s) Of Engagement Activity 2017
URL https://neurophys.gu.se/english/Research/second-swedish-diabetes-summit
 
Description SOR - Talk at Crick Institute opening symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Opening symposium of Crick Institute to include staff and scientists from the Crick, from founding partner universities (Imperial, KCL, UCL) and from the Sanger Institute.
Year(s) Of Engagement Activity 2017
 
Description SOR - Talk at Harvard Medical School, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited speaker at Dr Jeffrey Flier's 70th symposium at Harvard Medical School, USA. Dr Flier was 21st Dean of the Faculty of Medicine at Harvard University for 9 years. He is also an endocrinologist and an authority on the molecular causes of obesity and diabetes and previously served as Harvard Medical School Faculty Dean for Academic Programs and Chief Academic Officer for Beth Israel Deaconess Medical Center, a Harvard teaching affiliate. He is one of the country's leading investigators in the areas of obesity and diabetes. His research has produced major insights into the molecular mechanism of insulin action, the molecular mechanisms of insulin resistance in human disease, and the molecular pathophysiology of obesity.
Year(s) Of Engagement Activity 2018
 
Description SOR - Talk: German Diabetes Research School 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Two talks given on two consecutive days at a joint meeting of German Diabetes Research School and Insulin Resistance meetings in Nice
Year(s) Of Engagement Activity 2017
 
Description SOR - UK Congress on Obesity 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Invited speaker at UK Congress on Obesity 2017, ASO (Association for the Study of Obesity) 50th Anniversary Celebration Lecture, University of South Wales
Year(s) Of Engagement Activity 2017
 
Description SOR - WT Researcher meeting, Hinxton 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Annual presentation of work undertaken as a Wellcome Trust funding holder
Year(s) Of Engagement Activity 2018
 
Description SOR - What next for Genomics? 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact What Next for Genomics? Providing Answers, Changing Lives, Transforming the NHS' public event marking the Chief Medical Officer's Annual Report and launch of a new phase of the Genomics Conversation (organised by Progress Educational Trust, a charity working in partnership with Genomics England), Wellcome Collection, London. Audience (150) will be made up of a mixture of academics, medical professionals, patients and interested laypeople. It will be filmed. SOR expert panel member.
Year(s) Of Engagement Activity 2017
URL http://www.progress.org.uk/genomics
 
Description SOR 61st Annual meeting of German Endocrine Society, Bonn, Germany 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Gave plenary lecture
Year(s) Of Engagement Activity 2018
URL http://www.dge2018.de/programm.html
 
Description SOR ASN Chicago talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited to give 'State of the Art' lecture at Kidney Week - American Society of Nephrology (ASN) 50th Anniversary in Chicago, USA
Year(s) Of Engagement Activity 2016
URL https://www.asn-online.org/education/kidneyweek/2016/program-session-details.aspx?sess_id=412
 
Description SOR Academy of Medical Sciences 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Raised awareness of research and IMS

None
Year(s) Of Engagement Activity 2013
 
Description SOR Annual MedSoc talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Invited to give talk at St Catharine's College, Cambridge at the Annual Medical Society which is for medical and veterinary students
Year(s) Of Engagement Activity 2016
 
Description SOR Association of Children's Diabetes talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The Association of Children's Diabetes Clinicians is the group which represents all consultants, trainees and SAS doctors looking after children and young people with diabetes in the United Kingdom. Invited to give a talk at the 11th Annual ACDC Conference in Birmingham.
Year(s) Of Engagement Activity 2016
 
Description SOR Award Lecture for Zulch prize 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Raised awareness of research and IMS

Prestigious award of Zulch prize
Year(s) Of Engagement Activity 2014
URL http://www.mpg.de/8406171/zuelch_award_2014_orahilly_friedman
 
Description SOR BBC TV and Radio Interviews 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Raise awareness of research and IMS to the public

None
Year(s) Of Engagement Activity 2013
 
Description SOR CAM Magazine interview 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Raised awareness of research and IMS

Increased awareness of IMS
Year(s) Of Engagement Activity 2014
URL http://issuu.com/cambridgealumnirelationsoffice/docs/cam_72_online/29?e=2333249/8401871
 
Description SOR CSAR talk, University of Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Gave talk at Cambridge Society for the Application of Research on "Human Metabolic Disease, Lessons from the Extremes"

Raised awareness of research and of IMS
Year(s) Of Engagement Activity 2014
URL http://www.csar.org.uk/index.html
 
Description SOR CSaP 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Member of Centre for Science & Policy Executive Committee, University of Cambridge

None
Year(s) Of Engagement Activity 2013,2014
 
Description SOR CUSCRS talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Invited by Cambridge University Students' Clinical Research Society to give talk
Year(s) Of Engagement Activity 2016
 
Description SOR Cambridge Science Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Gave a talk 'Science of fat' at the annual Cambridge Science Festival
Year(s) Of Engagement Activity 2018
URL https://www.sciencefestival.cam.ac.uk/
 
Description SOR Crawford Lecture/Visiting Professorship, Massachusetts General Hospital, Boston, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited as Visiting Professorship to give Crawford Lecture at Massachusetts General Hospital, Boston, USA
Year(s) Of Engagement Activity 2016
 
Description SOR Dept of Health science seminar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact These seminars have been set up by the Deputy Chief Scientific Advisor at the DoH, Dr Mark Bale to promote science and scientists within the Department and focus on Department of Health priority areas such as obesity. The seminars run monthly in central London. Talks are attended by DoH staff as well as staff from the Medicines & Healthcare Products Regulatory Agency, Public Health England and NHS England. The talks are aimed to be broadly accessible as they will be attended by both scientists and non-scientists.
Year(s) Of Engagement Activity 2016
 
Description SOR Doha talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Invited guest speaker at Academic Health System lecture series at Hamad Medical Corporation, Doha, Qatar

Raise awareness of research and IMS
Year(s) Of Engagement Activity 2014
 
Description SOR Dublin Science Gallery 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Invited speaker at Trinity College Dublin Science Gallery as part of exhibition and 'Lab in the Gallery' FAT LAB. The goal of FAT LAB is to initiate a widespread re-evaluation of the perception of fat by inviting visitors to the gallery to participate in real research experiments and by creating a series of talks and events to engage our target audience of 15-25 year olds.

Raise awareness of research and IMS
Year(s) Of Engagement Activity 2014
URL https://dublin.sciencegallery.com/video/2014/07/sciencefatstephenorahillyanddonaloshea
 
Description SOR EMBO talk, Portugal 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited speaker at EMBO Workshop on Neural Control of Metabolism and Eating Behaviour, Portugal
Year(s) Of Engagement Activity 2016
 
Description SOR IMS World Congress on Menopause plenary talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited to give plenary talk at 15th Congress of the International Menopause Society (IMS) World Congress on the Menopause 'Heart Health Matters' in Prague, September 2016
Year(s) Of Engagement Activity 2016
URL http://www.imsprague2016.com/scientific-program/
 
Description SOR Irish Medical News feature 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Raised awareness of research and IMS

None
Year(s) Of Engagement Activity 2013
URL http://www.imn.ie/index.php?option=com_content&view=article&id=5418:arise-sir-orahilly&catid=57:clin...
 
Description SOR JCI Interview-Conversations with Giants in Medicine 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Raised awareness of research and IMS

None
Year(s) Of Engagement Activity 2013
URL http://www.jci.org/videos/cgms
 
Description SOR Lancet article 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Raised awareness of research and IMS

None
Year(s) Of Engagement Activity 2013
URL http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673613616220.pdf
 
Description SOR Life Sciences Seminar Series, University in Brno, Czech Republic 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Invited to give a talk in the Life Sciences Seminar Series in Masaryk, University in Brno, Czech Republic
Year(s) Of Engagement Activity 2018
 
Description SOR MRC Centenary Open Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Raised awareness of research and IMS among public

None
Year(s) Of Engagement Activity 2013
 
Description SOR MRC Festival of Research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Presentation along with other MRL colleagues for the MRC Festival of Research "We're getting fatter; does it matter?" held in Cambridge (with scientist and broadcaster Dr Chris Van Tulleken)
Year(s) Of Engagement Activity 2016
 
Description SOR MedSOC talk, Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Invited speaker at MedSOC talk, University of Cambridge

Raise awareness of research and of IMS
Year(s) Of Engagement Activity 2014
 
Description SOR Moncrieff Show for Newstalk interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Increased awareness of research and IMS

Increased awareness
Year(s) Of Engagement Activity 2015
 
Description SOR NIHR Rare Diseases Training event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact Raised awareness of rare diseases

Raised awareness
Year(s) Of Engagement Activity 2014
 
Description SOR National Health and Medical Research Council (NHMRC) CEO Obesity Roundtable 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Health professionals
Results and Impact Participated in roundtable discussion with members of Australian Government National Health and MRC and others

Raise awareness of research and IMS
Year(s) Of Engagement Activity 2014
 
Description SOR Newsweek interview 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Raised awareness of research and IMS

Recognition of article
Year(s) Of Engagement Activity 2014
URL http://www.newsweek.com/2015/01/30/prepare-pill-make-you-thin-301250.html
 
Description SOR Oration at Dermatological Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited to give the annual oration at St John's Dermatological Society in London to a clinical audience of ~150 dermatologists and trainees.
Year(s) Of Engagement Activity 2016
 
Description SOR Pharmacology tea club talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Invited to give University of Cambridge Department of Pharmacology tea club talk

Raise awareness of research and of IMS
Year(s) Of Engagement Activity 2014
 
Description SOR RTE interviews 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Raised awareness of research and IMS to the public

None
Year(s) Of Engagement Activity 2013
 
Description SOR SAC Conway 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Scientific Advisory Board

None
Year(s) Of Engagement Activity 2013
 
Description SOR SAC Crick Institute 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Scientific Advisory Board

None
Year(s) Of Engagement Activity 2013
 
Description SOR SAC Fondation Leducq 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Scientific Advisory Committee

None
Year(s) Of Engagement Activity 2013,2014
 
Description SOR Sensory Logic of the Gastronomic Brain workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Participation in workshop entitled "Sensory logic of the Gastronomic Brain" held at Basque Culinary Centre in San Sebastian, Spain. The full scientific meeting included 2.5 days with chefs and neuroscientists interacting in a workshop closed to the public. The workshop will consist in interactive discussions and experiments aiming at investigating outstanding questions related to neurogastronomy. The third day included a mini conference open to the public. The event was supported by the MRC Clinical Sciences Centre, Imperial College.
Year(s) Of Engagement Activity 2016
URL http://brainytongue.com/
 
Description SOR SfE BES 2016 talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited to give a talk at Society for Endocrinology BES 2016 annual conference in Brighton on 'My future career in endocrinology'.
Year(s) Of Engagement Activity 2016
 
Description SOR The Irish Times interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Recognised awareness of IMS and its research

Requests for further information
Year(s) Of Engagement Activity 2015
URL https://www.irishtimes.com/life-and-style/people/there-are-worse-things-in-this-world-than-being-fat...
 
Description SOR UCD MGA presentation lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Gave presentation when awarded Medical Graduates Association Distinguished Graduate Award from University College Dublin for 2014

Raised awareness of research and IMS
Year(s) Of Engagement Activity 2014
URL http://www.ucd.ie/medicine/ourcommunity/ouralumni/
 
Description SOR University of Bristol talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Invited speaker at University of Bristol MRC IEU Seminar Series

Raise awareness of research and IMS
Year(s) Of Engagement Activity 2014
 
Description SOR University of Leuven 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Gave talk at University of Leuven, Belgium in seminar series for high profile scientists aimed at broad audience

Raised awareness of research and IMS
Year(s) Of Engagement Activity 2014
 
Description SOR University of Manchester talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Invited speaker at University of Manchester at Faculty's Life Science 'Leaders in Science' Lecture Series

Raise awareness of research and IMS
Year(s) Of Engagement Activity 2014
 
Description SOR University of Massachusetts Medical School Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Invited as Molecular Medicine Distinguished Lecturer at the University of Massachusetts Medical School, Boston, USA
Year(s) Of Engagement Activity 2016
 
Description SOR University of the Third Age, Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Invited to give talk at University of the Third Age in Cambridge

Raise awareness of research and IMS
Year(s) Of Engagement Activity 2014
 
Description TVNZ one breakfast show interview, Aug 27th 2015 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact This live interview on New Zealand breakfast TV in support of the release of 'What's the right diet for you?' in Australia and New Zealand
Year(s) Of Engagement Activity 2015
URL http://tvnz.co.nz/breakfast-news/understanding-three-types-eaters-may-improve-diets-video-6379052
 
Description Talk on Public Engagement at the MRC Fellows' Symposium, London, 17/5/16 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk on public engagement to MRC Fellows at their annual symposium day in London
Year(s) Of Engagement Activity 2016
 
Description Talk on public engagement at the NIHR summer training camp, Aschridge, 7/7/16 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Talk on public engagement at the NIHR summer training camp, Aschridge, 7/7/16
Year(s) Of Engagement Activity 2016
 
Description Talk to the Cambridge branch of 'Pint of Science', 25/5/16 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Public lecture to the Cambridge branch of 'Pint of Science'
Year(s) Of Engagement Activity 2016
URL https://pintofscience.co.uk/event/why-are-we-fat
 
Description The Physiological Society Public Lecture Obesity: A Physiological Perspective, Newcastle United Football Club, Newcastle upon Tyne Newcastle, UK, September 10th - 12th 2014 Title 'Are your genes to blame when your jeans don't fit?' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Talk sparked questions and discussion afterwards

Members of the public seemed genuinely stimulated in their discussions. I also had an increase in my 'twitter-following'
Year(s) Of Engagement Activity 2014
 
Description The World Today, ABC News, Australia Obesity: now genes may be responsible for tight jeans, Maria Hatzakis reported this story on Monday, November 2, 2015 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact This was an interview on Australia National radio on obesity.
Year(s) Of Engagement Activity 2015
URL http://www.abc.net.au/worldtoday/content/2015/s4343585.htm
 
Description Today FM Interview, Ireland, Jan 13th, 2015 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact This interview on Irish radio in support of the BBC2 release of 'What's the right diet for you?'
Year(s) Of Engagement Activity 2015
URL http://www.todayfm.com/mobile/index.php?id=13408
 
Description University of Queensland Public Lecture, Brisbane, Australia, Nov 2nd 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact This was the annual public lecture given as part of the University of Queensland annual post-graduate symposium.
Year(s) Of Engagement Activity 2015
URL https://www.uq.edu.au/sbms/public-lecture-dr-giles-yeo-university-cambridge-are-your-genes-blame-whe...
 
Description What's the right diet for you? Horizon special, BBC2 Jan 12-14, 2015. 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Professor Fiona Gribble and Dr Giles Yeo (me) from the MRL and MRC Metabolic Diseases Unit in Cambridge, together with colleagues Professors Susan Jebb and Paul Aveyard from Oxford, featured in a 3-part BBC2 Horizon special 'What is the right diet for you?' in Jan 2015, following the trials and tribulations of 75 overweight volunteers looking to lose weight.

The programme put forward the key message that although obesity results from eating too much, the underlying influences on feeding behaviour are varied and complex, and explored whether diets could be 'tailored' to tackle these different factors.

In this instance, the investigators focussed on three groups of individuals - those with a higher genetic risk of becoming obese, those with a low gut hormone rise 30mins after a meal, and those who eat in response to stress.

By harnessing the power of genetics, together with biochemical and behavioural phenotyping, the programme provided a thoughtful and entertaining perspective on the current problem of obesity, and explored whether 'personalised' diets tailored to some of the root causes of overeating can succeed where more general dieting advice has failed.
Year(s) Of Engagement Activity 2015
URL http://www.bbc.co.uk/programmes/p02ddsd9
 
Description Wordfest 2013, 'Thinking aloud - Obesity' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact 150 in the audience

Extending the reach and improving public knowledge about obesity research
Year(s) Of Engagement Activity 2013
URL http://www.cambridgewordfest.co.uk/festivals/spring/event/view/thinkingaloudobesity
 
Description innvited talk to Diabetes UK annual professional conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact able to share our data with colleagues and clinicians from across the UK
Year(s) Of Engagement Activity 2019
 
Description seminar at University of Santiago de Compostela, Spain 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact discussion and collaboration afterwards reshaped the content of a review paper recently published in Cell Metabolism

link made for a post doc from Spain to come and spend time in our lab
Year(s) Of Engagement Activity
 
Description seminar given to Life Science Group in University of Manchester 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact met up with a number of PI in the institute to talk about the what GWAS studies mean and what kind of tools we need to move data forward

also used the visit to disucss the development of a joint grant submission to tackle a project on steroid biology that combines the skills of both groups
Year(s) Of Engagement Activity
 
Description seminar to Institute of Metabolic Science in Aberdeen 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact engaged with scientists in another centre of metabolic excellence to share ideas around common research interests
Year(s) Of Engagement Activity 2018
 
Description symposium on neuroendocrinology for British Society for Neuroendocrinology, British Neuroscience Association Annual Meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact a themed workshop to highlight the role of hormones and neuroendocrinology to an audience less used to thinking about the action of hormones in the brain
Year(s) Of Engagement Activity 2015