Mechanisms in Disorders of Energy Balance
Lead Research Organisation:
University of Cambridge
Abstract
We aim to understand the biological processes controlling what we eat and how we store and use energy. These pathways are disturbed in obesity and related metabolic conditions such as Type 2 diabetes, and this knowledge will, ultimately, lead to development of new treatments for these disorders.
We know that an individual’s genetic make up plays a significant role in determining their susceptibility to developing obesity and its deleterious consequences. Recent scientific and technological advances have made it substantially easier to analyse human genetic code. We aim to exploit data from human genetic studies to gain fundamental insights into what causes human obesity, and propose to combine these genetic studies with laboratory studies based around cell lines and whole animal models to better understand the pathways involved.
This programme builds upon our previous work centred around a large group of patients from around the world who developed severe obesity as children and who have formed the basis for subsequent detailed studies on food intake and energy use. While humans will always be our experimental subject of choice, there are important questions regarding mechanism which require alternative approaches. In particular, we plan to use rodent models to explore aspects of disease processes that cannot be readily addressed in humans. Further, rodents have the advantage of being readily susceptible to genetic manipulation allowing precise alteration of specific genes and, importantly, the creation of animal models of relevant, specific, human diseases.
We know that an individual’s genetic make up plays a significant role in determining their susceptibility to developing obesity and its deleterious consequences. Recent scientific and technological advances have made it substantially easier to analyse human genetic code. We aim to exploit data from human genetic studies to gain fundamental insights into what causes human obesity, and propose to combine these genetic studies with laboratory studies based around cell lines and whole animal models to better understand the pathways involved.
This programme builds upon our previous work centred around a large group of patients from around the world who developed severe obesity as children and who have formed the basis for subsequent detailed studies on food intake and energy use. While humans will always be our experimental subject of choice, there are important questions regarding mechanism which require alternative approaches. In particular, we plan to use rodent models to explore aspects of disease processes that cannot be readily addressed in humans. Further, rodents have the advantage of being readily susceptible to genetic manipulation allowing precise alteration of specific genes and, importantly, the creation of animal models of relevant, specific, human diseases.
Technical Summary
Obesity and its metabolic consequences are major threats to public health with an unmet need for improved therapy and prevention. Understanding the mechanisms involved in the control of human energy balance is essential to develop new treatments.
By focusing upon a cohort of patients with severe early onset obesity, we have uncovered novel, highly penetrant alleles causing childhood obesity and gone on to establish the mechanisms of molecular dysfunction in many of these conditions. More recently, new and important insights into the genetic basis of common obesity are beginning to emerge from hypothesis-free genome-wide approaches. There is, at present, an important gap between the identification of an allele as being unequivocally associated with an adiposity phenotype and understanding how that allele actually influences energy balance. Building upon our established expertise, we aim to use a range of research methodologies to close that gap and turn statistical association into a deeper understanding of biology. This includes, when necessary and appropriate, the use of model organisms. While humans will always be our experimental subject of choice, and while advances in technology increasingly allow us to undertake more sophisticated non-invasive studies in humans, there are important questions regarding physiology and pathophysiology that require the use of animal studies. For example, as the hypothalamus is a key centre for energy and metabolic regulation, animal studies provide the only way in which direct and meaningful manipulation of hypothalamic function can be undertaken.
This programme will include the in vitro study of the biochemical properties of variant molecules as well as studies in heterologously expressing mutant genes to determine the biological consequences of genetic variants at a cellular level. This work will both inform and be influenced by on–going in vivo studies utilising mouse models of novel human genetic diseases. The phenotypic evaluation of such mice will be comprehensive, not only including studies of body composition, energy balance and intermediary metabolism but also involving increasingly sophisticated behavioural analysis. We will feed back the information from these studios into relevant clinical programmes, particularly those of Farooqi and Wareham (MRC Epidemiology Unit) where findings in the miceshould inform further targeted evaluation of human phenotypes.
By focusing upon a cohort of patients with severe early onset obesity, we have uncovered novel, highly penetrant alleles causing childhood obesity and gone on to establish the mechanisms of molecular dysfunction in many of these conditions. More recently, new and important insights into the genetic basis of common obesity are beginning to emerge from hypothesis-free genome-wide approaches. There is, at present, an important gap between the identification of an allele as being unequivocally associated with an adiposity phenotype and understanding how that allele actually influences energy balance. Building upon our established expertise, we aim to use a range of research methodologies to close that gap and turn statistical association into a deeper understanding of biology. This includes, when necessary and appropriate, the use of model organisms. While humans will always be our experimental subject of choice, and while advances in technology increasingly allow us to undertake more sophisticated non-invasive studies in humans, there are important questions regarding physiology and pathophysiology that require the use of animal studies. For example, as the hypothalamus is a key centre for energy and metabolic regulation, animal studies provide the only way in which direct and meaningful manipulation of hypothalamic function can be undertaken.
This programme will include the in vitro study of the biochemical properties of variant molecules as well as studies in heterologously expressing mutant genes to determine the biological consequences of genetic variants at a cellular level. This work will both inform and be influenced by on–going in vivo studies utilising mouse models of novel human genetic diseases. The phenotypic evaluation of such mice will be comprehensive, not only including studies of body composition, energy balance and intermediary metabolism but also involving increasingly sophisticated behavioural analysis. We will feed back the information from these studios into relevant clinical programmes, particularly those of Farooqi and Wareham (MRC Epidemiology Unit) where findings in the miceshould inform further targeted evaluation of human phenotypes.
Organisations
- University of Cambridge, United Kingdom (Lead Research Organisation)
- Max Planck Society (Collaboration)
- University of Edinburgh, United Kingdom (Collaboration)
- University of Gothenburg, Sweden (Collaboration)
- University Hospital Tuebingen (Collaboration)
- Utrecht University (Collaboration)
- University of Duisburg-Essen, Germany (Collaboration)
- Julich Research Centre, Germany (Collaboration)
- Pasteur Institute, Lille (Collaboration)
- Wageningen University, Netherlands (Collaboration)
- Helmholtz Association of German Research Centres (Collaboration)
- Spanish Ministry of Health and Consumer Affairs (Collaboration)
- National Institute of Health and Medical Research (INSERM) (Collaboration)
- Cochin Institute (Collaboration)
- Heinrich Heine University Düsseldorf (Collaboration)
- University Clinic Lubeck (Collaboration)
- Norwegian University of Science and Technology (NTNU) (Collaboration)
- University Medical Center Freiburg (Collaboration)
- University Clinic Dresden (Collaboration)
- Imperial College London, United Kingdom (Collaboration)
- Harokopio University (Collaboration)
- Maastricht University (UM) (Collaboration)
- RWTH Aachen University, Germany (Collaboration)
- The Wellcome Trust Sanger Institute (Collaboration)
- Yale University (Collaboration)
- University of Leeds, United Kingdom (Collaboration)
- University of Copenhagen, Denmark (Collaboration)
- University of Aberdeen, United Kingdom (Collaboration)
- Takeda Cambridge Ltd (Collaboration)
- Helmholtz Zentrum München (Collaboration)
- German Cancer Research Center (Collaboration)
- Charité - University of Medicine Berlin (Collaboration)
- University of Manchester, Manchester, United Kingdom (Collaboration)
- University of Leipzig, Germany (Collaboration)
Publications
Allum F
(2015)
Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants.
in Nature communications
Asai M
(2013)
Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity.
in Science (New York, N.Y.)
Azizan EA
(2013)
Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension.
in Nature genetics
Billing LJ
(2018)
Co-storage and release of insulin-like peptide-5, glucagon-like peptide-1 and peptideYY from murine and human colonic enteroendocrine cells.
in Molecular metabolism
Carr SK
(2014)
Maternal diet amplifies the hepatic aging trajectory of Cidea in male mice and leads to the development of fatty liver.
in FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Challis BG
(2015)
Heterogeneity of glucagonomas due to differential processing of proglucagon-derived peptides.
in Endocrinology, diabetes & metabolism case reports
Cheung MK
(2013)
FTO expression is regulated by availability of essential amino acids.
in International journal of obesity (2005)
Cimino I
(2017)
GDF15 and energy balance: homing in on a mechanism.
in Nature medicine
Coll AP
(2018)
Monogenic Obesity; Using Drugs to Bypass the Problem.
in Cell metabolism
| Description | MRC Workshop on Neuroscience of Obesity: Gut-brain communication |
| Geographic Reach | National |
| Policy Influence Type | Participation in advisory committee |
| Description | SOR Parliamentary report on sugar (acted as expert health professional in telephone interview) |
| Geographic Reach | Australia |
| Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
| Description | A glucose-responsive network |
| Amount | £609,000 (GBP) |
| Funding ID | MR/R002991/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2017 |
| End | 09/2020 |
| Description | Consequences of targeted SNORD116 deletion in human and mouse neurons |
| Amount | $64,799 (USD) |
| Organisation | Foundation for Prader-Willi Research (FPWR) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 03/2019 |
| Description | Recapitulating obesity and hyperphagia in novel adult-onset mouse models of Snord116 deletion |
| Amount | $87,600 (USD) |
| Organisation | Foundation for Prader-Willi Research (FPWR) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2016 |
| End | 09/2017 |
| Description | EurOCHIP |
| Organisation | Cochin Institute |
| Department | INSERM U1016 |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Coordinator |
| Collaborator Contribution | European Obesity Consortium studying the Hypothalamus and its Interaction with the Periphery |
| Impact | European Obesity Consortium studying the Hypothalamus and its Interaction with the Periphery |
| Start Year | 2009 |
| Description | EurOCHIP |
| Organisation | Helmholtz Zentrum München |
| Department | Institute for Diabetes and Obesity |
| Country | Germany |
| Sector | Public |
| PI Contribution | Coordinator |
| Collaborator Contribution | European Obesity Consortium studying the Hypothalamus and its Interaction with the Periphery |
| Impact | European Obesity Consortium studying the Hypothalamus and its Interaction with the Periphery |
| Start Year | 2009 |
| Description | EurOCHIP |
| Organisation | Imperial College London |
| Department | Division of Diabetes, Endocrinology & Metabolism |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Coordinator |
| Collaborator Contribution | European Obesity Consortium studying the Hypothalamus and its Interaction with the Periphery |
| Impact | European Obesity Consortium studying the Hypothalamus and its Interaction with the Periphery |
| Start Year | 2009 |
| Description | EurOCHIP |
| Organisation | Max Planck Society |
| Department | Max Planck Institute for Neurological Research |
| Country | Germany |
| Sector | Public |
| PI Contribution | Coordinator |
| Collaborator Contribution | European Obesity Consortium studying the Hypothalamus and its Interaction with the Periphery |
| Impact | European Obesity Consortium studying the Hypothalamus and its Interaction with the Periphery |
| Start Year | 2009 |
| Description | EurOCHIP |
| Organisation | Pasteur Institute, Lille |
| Country | France |
| Sector | Charity/Non Profit |
| PI Contribution | Coordinator |
| Collaborator Contribution | European Obesity Consortium studying the Hypothalamus and its Interaction with the Periphery |
| Impact | European Obesity Consortium studying the Hypothalamus and its Interaction with the Periphery |
| Start Year | 2009 |
| Description | EurOCHIP |
| Organisation | University of Gothenburg |
| Department | Sahlgrenska Academy |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | Coordinator |
| Collaborator Contribution | European Obesity Consortium studying the Hypothalamus and its Interaction with the Periphery |
| Impact | European Obesity Consortium studying the Hypothalamus and its Interaction with the Periphery |
| Start Year | 2009 |
| Description | Full4health |
| Organisation | Harokopio University |
| Country | Greece |
| Sector | Academic/University |
| PI Contribution | Partner |
| Collaborator Contribution | Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health |
| Impact | Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health |
| Start Year | 2011 |
| Description | Full4health |
| Organisation | Maastricht University (UM) |
| Department | School for Nutrition, Toxicology and Metabolism (NUTRIM) |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Partner |
| Collaborator Contribution | Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health |
| Impact | Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health |
| Start Year | 2011 |
| Description | Full4health |
| Organisation | Max Planck Society |
| Department | Max Planck Institute for Neurological Research |
| Country | Germany |
| Sector | Public |
| PI Contribution | Partner |
| Collaborator Contribution | Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health |
| Impact | Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health |
| Start Year | 2011 |
| Description | Full4health |
| Organisation | National Institute of Health and Medical Research (INSERM) |
| Department | Inserm U837 UMR-S 1172 Jean Pierre Aubert Research Centre |
| Country | France |
| Sector | Public |
| PI Contribution | Partner |
| Collaborator Contribution | Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health |
| Impact | Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health |
| Start Year | 2011 |
| Description | Full4health |
| Organisation | Norwegian University of Science and Technology (NTNU) |
| Country | Norway |
| Sector | Academic/University |
| PI Contribution | Partner |
| Collaborator Contribution | Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health |
| Impact | Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health |
| Start Year | 2011 |
| Description | Full4health |
| Organisation | University of Aberdeen |
| Department | Rowett Institute of Nutrition and Health Aberdeen |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Partner |
| Collaborator Contribution | Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health |
| Impact | Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health |
| Start Year | 2011 |
| Description | Full4health |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Partner |
| Collaborator Contribution | Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health |
| Impact | Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health |
| Start Year | 2011 |
| Description | Full4health |
| Organisation | University of Edinburgh |
| Department | Centre for Integrative Physiology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Partner |
| Collaborator Contribution | Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health |
| Impact | Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health |
| Start Year | 2011 |
| Description | Full4health |
| Organisation | University of Gothenburg |
| Department | Sahlgrenska Academy |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | Partner |
| Collaborator Contribution | Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health |
| Impact | Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health |
| Start Year | 2011 |
| Description | Full4health |
| Organisation | University of Leeds |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Partner |
| Collaborator Contribution | Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health |
| Impact | Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health |
| Start Year | 2011 |
| Description | Full4health |
| Organisation | University of Wageningen |
| Department | Division of Human Nutrition |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Partner |
| Collaborator Contribution | Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health |
| Impact | Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health |
| Start Year | 2011 |
| Description | Full4health |
| Organisation | Utrecht University |
| Department | Rudolf Magnus Institute |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Partner |
| Collaborator Contribution | Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health |
| Impact | Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health |
| Start Year | 2011 |
| Description | ICEMED |
| Organisation | Charité - University of Medicine Berlin |
| Department | Paediatric and Adolescent Medicine |
| Country | Germany |
| Sector | Hospitals |
| PI Contribution | Partner |
| Collaborator Contribution | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Impact | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Start Year | 2012 |
| Description | ICEMED |
| Organisation | German Cancer Research Center |
| Country | Germany |
| Sector | Public |
| PI Contribution | Partner |
| Collaborator Contribution | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Impact | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Start Year | 2012 |
| Description | ICEMED |
| Organisation | Heinrich Heine University Düsseldorf |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Partner |
| Collaborator Contribution | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Impact | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Start Year | 2012 |
| Description | ICEMED |
| Organisation | Helmholtz Association of German Research Centres |
| Department | The Max Delbrück Center for Molecular Medicine (MDC) |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Partner |
| Collaborator Contribution | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Impact | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Start Year | 2012 |
| Description | ICEMED |
| Organisation | Helmholtz Zentrum München |
| Department | Institute of Stem Cell Research |
| Country | Germany |
| Sector | Charity/Non Profit |
| PI Contribution | Partner |
| Collaborator Contribution | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Impact | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Start Year | 2012 |
| Description | ICEMED |
| Organisation | Julich Research Centre |
| Country | Germany |
| Sector | Public |
| PI Contribution | Partner |
| Collaborator Contribution | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Impact | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Start Year | 2012 |
| Description | ICEMED |
| Organisation | Max Planck Society |
| Department | Max Planck Institute for Neurological Research |
| Country | Germany |
| Sector | Public |
| PI Contribution | Partner |
| Collaborator Contribution | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Impact | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Start Year | 2012 |
| Description | ICEMED |
| Organisation | RWTH Aachen University |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Partner |
| Collaborator Contribution | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Impact | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Start Year | 2012 |
| Description | ICEMED |
| Organisation | University Clinic Dresden |
| Country | Germany |
| Sector | Hospitals |
| PI Contribution | Partner |
| Collaborator Contribution | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Impact | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Start Year | 2012 |
| Description | ICEMED |
| Organisation | University Clinic Lubeck |
| Country | Germany |
| Sector | Hospitals |
| PI Contribution | Partner |
| Collaborator Contribution | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Impact | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Start Year | 2012 |
| Description | ICEMED |
| Organisation | University Duisburg-Essen |
| Department | Faculty of Medicine |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Partner |
| Collaborator Contribution | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Impact | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Start Year | 2012 |
| Description | ICEMED |
| Organisation | University Hospital Tuebingen |
| Country | Germany |
| Sector | Hospitals |
| PI Contribution | Partner |
| Collaborator Contribution | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Impact | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Start Year | 2012 |
| Description | ICEMED |
| Organisation | University Medical Center Freiburg |
| Department | Department of Radiology |
| Country | Germany |
| Sector | Hospitals |
| PI Contribution | Partner |
| Collaborator Contribution | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Impact | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Start Year | 2012 |
| Description | ICEMED |
| Organisation | University of Leipzig |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Partner |
| Collaborator Contribution | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Impact | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Start Year | 2012 |
| Description | ICEMED |
| Organisation | Yale University |
| Department | School of Medicine |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Partner |
| Collaborator Contribution | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Impact | Imaging and Curing Environmental Metabolic Diseases' Consortium award amount |
| Start Year | 2012 |
| Description | Macrophages and lipotoxicity. |
| Organisation | Spanish Ministry of Health and Consumer Affairs |
| Department | National Center for Cardiovascular Research (CNIC) |
| Country | Spain |
| Sector | Public |
| PI Contribution | ongoing intellectual and experimental collaboration |
| Collaborator Contribution | access to facilities and expertise not otherwise available |
| Impact | publication in preparation |
| Start Year | 2007 |
| Description | characterisation of a novel model of obesity involving a paternally expressed gene |
| Organisation | Max Planck Society |
| Department | Max Planck Institute of Immunobiology and Epigenetics |
| Country | Germany |
| Sector | Public |
| PI Contribution | collaboration on a novel model of obesity involving imprinted paternally expressed genes detailed phenotyping of mouse model |
| Collaborator Contribution | intellectual guidance, mouse resources |
| Impact | publication currently being written |
| Start Year | 2013 |
| Description | collaboration to study a novel model of obesity and developmental delay |
| Organisation | The Wellcome Trust Sanger Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | just beginning this collaboration after frutiful discussion around imprinted genes and obesity |
| Collaborator Contribution | generation and phenotyping of this mouse model |
| Impact | no output yet |
| Start Year | 2016 |
| Description | description of novel role for gut peptide Insl5 |
| Organisation | Takeda Cambridge Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | undertook in vivo studies of action of peptide on food intake |
| Collaborator Contribution | generation of murine models and parallel physiological studies of role of peptide |
| Impact | publication in PNAS- ( Grosse et al, 2014, PMID: 25028498) |
| Start Year | 2007 |
| Description | development of a model of metabolic consequences of glucocorticoid therapy |
| Organisation | University of Manchester |
| Department | Division of Cell Matrix Biology and Regenerative Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | intellectual input, murine reagents, technical expertise |
| Collaborator Contribution | murine models, manpower, technical expertise, intellectual input |
| Impact | Manuscript published in Endocrinology , Nov 2016 (Harno et al, PMID: 27649090) |
| Start Year | 2014 |
| Description | generation and characterisation of novel mouse model of MRAP2 |
| Organisation | The Wellcome Trust Sanger Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | undertook detailed phenotyping of energy expenditure of mouse model |
| Collaborator Contribution | mouse developed using technology available at Sanger |
| Impact | generation of a mouse model, |
| Start Year | 2012 |
| Description | 'ARE YOUR GENES TO BLAME WHEN YOUR JEANS DON'T FIT?' Talk at the Hay Festival 2016 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | ARE YOUR GENES TO BLAME WHEN YOUR JEANS DON'T FIT?, talk at the Hay Festival 2016 as part of the Cambridge series. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.hayfestival.com/p-11106-giles-yeo.aspx |
| Description | 'If your jeans don't fit, maybe your genes don't fit?' - Authored piece for the Sunday Times, Jan 12th 2015 |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | This authored piece in the 'Review' section of the Sunday Times was written in support of the BBC2 release of 'What's the right diet for you?', in which I was one of the scientific experts. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.thesundaytimes.co.uk/sto/newsreview/features/article1505198.ece |
| Description | 'Role of FTO as a brain nutrient sensor' - Invited symposium speaker at the American Diabetes Association annual meeting in New Orleans, 10/6/16 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 'Role of FTO as a brain nutrient sensor' - Invited symposium speaker at the American Diabetes Association annual meeting in New Orleans, 10/6/16 |
| Year(s) Of Engagement Activity | 2016 |
| Description | 2015 Keynote Speaker Foundation of European Nurses in Diabetes Annual Meeting, Stockholm, Sweden, September 12th 2015. Title 'Genomics in Obesity Management' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 200 diabetic nurses attended, which is not normally who I speak to. This sparked interesting discussions |
| Year(s) Of Engagement Activity | 2015 |
| Description | Abcam meeting, Fitzwilliam ,Cambridge 2013 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | "Melanocortins and beyond - the hypothalamic control of energy balance" AP Coll Programming Obesity: Central and Peripheral Contributors April 14-16, 2013 Fitzwilliam College, University of Cambridge useful post presentation discussion with peers on how to take evolving data forward |
| Year(s) Of Engagement Activity | 2013 |
| Description | Appearance on Radio 4's 'Start the week' with Andrew Marr on 6/6/16 |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Appeared on R4's 'Start the week' with Andrew Marr, discussing Genes and Inheritance. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.bbc.co.uk/programmes/b07dkk09 |
| Description | Authored piece in the DailyMail on the utility of commercial genetic tests in predicting disease 'Should you take a gene test to tell if you will put on weight? Don't waste your cash' |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | This authored piece in the DailyMail (which I only agreed to because it was authored) generated quite a bit of public interest on twitter |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.dailymail.co.uk/health/article-2987372/Should-gene-test-tell-weight-Don-t-waste-cash.html |
| Description | BBC Four documentary |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Filmed and interviewed for BBC Four documentary on the history of how we came to understand hormones, specifically regarding work on leptin. N/A - documentary is yet to air. |
| Year(s) Of Engagement Activity | 2013 |
| Description | BBC Radio Cambridgeshire interview (Apr 2013) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Raised awareness of obesity and genetics. |
| Year(s) Of Engagement Activity | 2013 |
| Description | Cambridge Science Festival - 'Starch, Milk and Alcohol' 11th March 2016 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | This is a lecture at the Annual Cambridge Science Festival, which is the biggest 'free to attend' Science festival of its kind in the UK |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.eventbrite.co.uk/e/starch-milk-and-alcohol-tickets-19842258730 |
| Description | Expert contributor, Fat Family Tree, Channel 4 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Channel 4 documentary on genetics of obesity, aired on 23rd May, 2013 Increasing public awareness of genetics of obesity |
| Year(s) Of Engagement Activity | 2013 |
| URL | http://www.channel4.com/programmes/fat-family-tree/episode-guide |
| Description | Interview on Real Nutrition Radio - Are gene tests worth it? 8th June 2015 |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | This interview dealt with the utility of genetic testing in so-called 'nutri-genomics'....punch line, it will happen one day perhaps, but not yet! |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.realnutritionradio.com/podcast/ep17-are-genetic-tests-worth-it-with-giles-yeo/ |
| Description | Interview on The Kim Hill show, on New Zealand National Radio, Sep 5th 2015 |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | This was a 45 min interview about obesity on New Zealand National Radio with Kim Hill, the doyenne of NZ talk radio. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://omnyapp.com/shows/rnz-saturday-morning/giles-yeo-obesity-and-genetics |
| Description | Interview with the Naked Scientists Radio Show, ' Why are people prone to gaining weight?' Jan 12th 2015, |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The initial show when out live on BBC radio cambridgeshire. The podcast of this then was released internationally. Lots of twitter comments and feedback. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.thenakedscientists.com/HTML/interviews/interview/1001083/ |
| Description | MRC Centenary Exhibition |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Type Of Presentation | Poster Presentation |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | as part of MRC centenary, our laboratory space was open to the public. Across an afternoon over 60 people came on guided tour of the lab, with manned poster stations highlighting research activity great deal of interest from a number of 6th formers who wish to try and return to the lab as summer visitors |
| Year(s) Of Engagement Activity | 2013 |
| Description | Presentation in the BBC Science Zone, at the 2015 Cheltenham Science Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | This appearance at the Cheltenham Science Festival was a real experience. But the real benefit to me was I ended up being recruited to present my own BBC Horizon documentary! |
| Year(s) Of Engagement Activity | 2015 |
| Description | Presented 'Clean eating - The dirty truth' for BBC2 Horizon, aired 19/1/17 |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Presented 'Clean eating - The dirty truth' for BBC2 Horizon, aired 19/1/17 |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.bbc.co.uk/programmes/b08bhd29 |
| Description | Presented 'Why are we getting so fat?', a BBC2 Horizon Documentary, aired 7/6/16 |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | I presented 'Why are we getting so fat' for BBC2 Horizon, which transmitted on 7/6/16. Viewing figures were 2 million in the UK. Has been aired now all over the world. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.bbc.co.uk/programmes/b07fys2y |
| Description | Press release for Cell article (Oct 2013) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Raised awareness of obesity and genetics. |
| Year(s) Of Engagement Activity | 2013 |
| URL | http://www.cell.com/abstract/S0092-8674(13)01276-2 |
| Description | Press release for Nature Genetics article (Aug 2013) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Raised awareness of obesity and genetics. |
| Year(s) Of Engagement Activity | 2013 |
| URL | http://www.nature.com/ng/journal/v45/n9/full/ng.2716.html |
| Description | Press release for Science paper (July 2013) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Raised awareness of obesity and genetics. |
| Year(s) Of Engagement Activity | 2013 |
| URL | http://www.sciencemag.org/content/341/6143/275.full |
| Description | Radio interview with Heart FM (Apr 2013) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Raised awareness of obesity and genetics. |
| Year(s) Of Engagement Activity | 2013 |
| Description | SOR - Cardiometabolic early careers researchers event, Cambridge |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Invited keynote speaker at Cambridge Cardio-metabolic early careers researchers event at St Catharine's College, Cambridge. The event is aimed at encouraging collaboration and connectivity and is a joint meeting between the Cambridge Cardiovascular Strategic Research Initiative and the Cambridge Metabolic Network and will support integrative cardiometabolic science through sessions to showcase collaboration across the research themes. There will also be sessions to help participants form new connections through mutual interest in techniques and discussions around their research connections. |
| Year(s) Of Engagement Activity | 2017 |
| Description | SOR - Cell Symposium, San Diego |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker at Cell Symposium |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.cell-symposia.com/metabolic-therapies-2017/conference-program.asp |
| Description | SOR - Dept of Vet Medicine Research afternoon |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | University of Cambridge Department of Veterinary Medicine Research afternoon |
| Year(s) Of Engagement Activity | 2017 |
| Description | SOR - Faulkner Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited to give the annual John A Faulkner lectureship at the University of Michigan. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://medicine.umich.edu/dept/molecular-integrative-physiology/events/201710/faulkner-lecture-prof... |
| Description | SOR - IFSO World Congress, London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Gave a talk at Best of British Symposium at IFSO (International Federation for the Surgery of Obesity and Metabolic Disorders) World Congress held in London |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.ifso2017.com/ |
| Description | SOR - Keynote lecture at GVS |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | The Gynaecological Visiting Society of Great Britain and Ireland's 2017 Meeting in Cambridge which is a meeting of senior academics in Obstetrics and Gynaecology in the UK. |
| Year(s) Of Engagement Activity | 2017 |
| Description | SOR - Keystone mtg, Copenhagen |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Keystone meeting: Neuronal control of appetite, metabolism and weight |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1458 |
| Description | SOR - King's College DNS Postgrad Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other audiences |
| Results and Impact | Gave talk at King's College London DNS (Departments of Diabetes and Nutritional Sciences) Postgraduate Symposium |
| Year(s) Of Engagement Activity | 2017 |
| Description | SOR - Pembroke College Campaign Launch |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Talk given by fellows of Pembroke College for its Campaign Launch |
| Year(s) Of Engagement Activity | 2017 |
| Description | SOR - Pembroke College Campaign event |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Pembroke College Campaign event held at the Royal Society in London |
| Year(s) Of Engagement Activity | 2017 |
| Description | SOR - RIA Masterclass and discourse |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | As newly appointed honorary member of Royal Irish Academy, invited to give masterclass and Academy discourse |
| Year(s) Of Engagement Activity | 2017 |
| Description | SOR - Rare Diseases MP visit |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Visit by Cambridge MP as part of International Rare Disease Day celebrations, including informal roundtable discussion on rare diseases with researcher community and patients |
| Year(s) Of Engagement Activity | 2017 |
| Description | SOR - Sri Lanka College of Endocrine 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Three talks in two days given during Sri Lanka College of Endocrine 2017 meeting in Colombo |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://ecsl2017.com/download/ecsl-2017-flyer-programme.pdf |
| Description | SOR - Swedish Diabetes Summit |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker at 2nd Swedish Diabetes Summit held at Gothenburg which was jointly organised by the Sahlgrenska Academy of Gothenburg University and AstraZeneca |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://neurophys.gu.se/english/Research/second-swedish-diabetes-summit |
| Description | SOR - Talk at Crick Institute opening symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Opening symposium of Crick Institute to include staff and scientists from the Crick, from founding partner universities (Imperial, KCL, UCL) and from the Sanger Institute. |
| Year(s) Of Engagement Activity | 2017 |
| Description | SOR - Talk: German Diabetes Research School |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Two talks given on two consecutive days at a joint meeting of German Diabetes Research School and Insulin Resistance meetings in Nice |
| Year(s) Of Engagement Activity | 2017 |
| Description | SOR - UK Congress on Obesity 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker at UK Congress on Obesity 2017, ASO (Association for the Study of Obesity) 50th Anniversary Celebration Lecture, University of South Wales |
| Year(s) Of Engagement Activity | 2017 |
| Description | SOR - What next for Genomics? |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | What Next for Genomics? Providing Answers, Changing Lives, Transforming the NHS' public event marking the Chief Medical Officer's Annual Report and launch of a new phase of the Genomics Conversation (organised by Progress Educational Trust, a charity working in partnership with Genomics England), Wellcome Collection, London. Audience (150) will be made up of a mixture of academics, medical professionals, patients and interested laypeople. It will be filmed. SOR expert panel member. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.progress.org.uk/genomics |
| Description | SOR ASN Chicago talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited to give 'State of the Art' lecture at Kidney Week - American Society of Nephrology (ASN) 50th Anniversary in Chicago, USA |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.asn-online.org/education/kidneyweek/2016/program-session-details.aspx?sess_id=412 |
| Description | SOR Academy of Medical Sciences |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Raised awareness of research and IMS None |
| Year(s) Of Engagement Activity | 2013 |
| Description | SOR Annual MedSoc talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited to give talk at St Catharine's College, Cambridge at the Annual Medical Society which is for medical and veterinary students |
| Year(s) Of Engagement Activity | 2016 |
| Description | SOR Association of Children's Diabetes talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | The Association of Children's Diabetes Clinicians is the group which represents all consultants, trainees and SAS doctors looking after children and young people with diabetes in the United Kingdom. Invited to give a talk at the 11th Annual ACDC Conference in Birmingham. |
| Year(s) Of Engagement Activity | 2016 |
| Description | SOR Award Lecture for Zulch prize |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Raised awareness of research and IMS Prestigious award of Zulch prize |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.mpg.de/8406171/zuelch_award_2014_orahilly_friedman |
| Description | SOR BBC TV and Radio Interviews |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Raise awareness of research and IMS to the public None |
| Year(s) Of Engagement Activity | 2013 |
| Description | SOR CAM Magazine interview |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Raised awareness of research and IMS Increased awareness of IMS |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://issuu.com/cambridgealumnirelationsoffice/docs/cam_72_online/29?e=2333249/8401871 |
| Description | SOR CSAR talk, University of Cambridge |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Gave talk at Cambridge Society for the Application of Research on "Human Metabolic Disease, Lessons from the Extremes" Raised awareness of research and of IMS |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.csar.org.uk/index.html |
| Description | SOR CSaP |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Member of Centre for Science & Policy Executive Committee, University of Cambridge None |
| Year(s) Of Engagement Activity | 2013,2014 |
| Description | SOR CUSCRS talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Invited by Cambridge University Students' Clinical Research Society to give talk |
| Year(s) Of Engagement Activity | 2016 |
| Description | SOR Crawford Lecture/Visiting Professorship, Massachusetts General Hospital, Boston, USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited as Visiting Professorship to give Crawford Lecture at Massachusetts General Hospital, Boston, USA |
| Year(s) Of Engagement Activity | 2016 |
| Description | SOR Dept of Health science seminar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | These seminars have been set up by the Deputy Chief Scientific Advisor at the DoH, Dr Mark Bale to promote science and scientists within the Department and focus on Department of Health priority areas such as obesity. The seminars run monthly in central London. Talks are attended by DoH staff as well as staff from the Medicines & Healthcare Products Regulatory Agency, Public Health England and NHS England. The talks are aimed to be broadly accessible as they will be attended by both scientists and non-scientists. |
| Year(s) Of Engagement Activity | 2016 |
| Description | SOR Doha talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Invited guest speaker at Academic Health System lecture series at Hamad Medical Corporation, Doha, Qatar Raise awareness of research and IMS |
| Year(s) Of Engagement Activity | 2014 |
| Description | SOR Dublin Science Gallery |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited speaker at Trinity College Dublin Science Gallery as part of exhibition and 'Lab in the Gallery' FAT LAB. The goal of FAT LAB is to initiate a widespread re-evaluation of the perception of fat by inviting visitors to the gallery to participate in real research experiments and by creating a series of talks and events to engage our target audience of 15-25 year olds. Raise awareness of research and IMS |
| Year(s) Of Engagement Activity | 2014 |
| URL | https://dublin.sciencegallery.com/video/2014/07/sciencefatstephenorahillyanddonaloshea |
| Description | SOR EMBO talk, Portugal |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker at EMBO Workshop on Neural Control of Metabolism and Eating Behaviour, Portugal |
| Year(s) Of Engagement Activity | 2016 |
| Description | SOR IMS World Congress on Menopause plenary talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited to give plenary talk at 15th Congress of the International Menopause Society (IMS) World Congress on the Menopause 'Heart Health Matters' in Prague, September 2016 |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.imsprague2016.com/scientific-program/ |
| Description | SOR Irish Medical News feature |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Raised awareness of research and IMS None |
| Year(s) Of Engagement Activity | 2013 |
| URL | http://www.imn.ie/index.php?option=com_content&view=article&id=5418:arise-sir-orahilly&catid=57:clin... |
| Description | SOR JCI Interview-Conversations with Giants in Medicine |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Raised awareness of research and IMS None |
| Year(s) Of Engagement Activity | 2013 |
| URL | http://www.jci.org/videos/cgms |
| Description | SOR Lancet article |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Raised awareness of research and IMS None |
| Year(s) Of Engagement Activity | 2013 |
| URL | http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673613616220.pdf |
| Description | SOR MRC Centenary Open Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Raised awareness of research and IMS among public None |
| Year(s) Of Engagement Activity | 2013 |
| Description | SOR MRC Festival of Research |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Presentation along with other MRL colleagues for the MRC Festival of Research "We're getting fatter; does it matter?" held in Cambridge (with scientist and broadcaster Dr Chris Van Tulleken) |
| Year(s) Of Engagement Activity | 2016 |
| Description | SOR MedSOC talk, Cambridge |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited speaker at MedSOC talk, University of Cambridge Raise awareness of research and of IMS |
| Year(s) Of Engagement Activity | 2014 |
| Description | SOR Moncrieff Show for Newstalk interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Increased awareness of research and IMS Increased awareness |
| Year(s) Of Engagement Activity | 2015 |
| Description | SOR NIHR Rare Diseases Training event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | Raised awareness of rare diseases Raised awareness |
| Year(s) Of Engagement Activity | 2014 |
| Description | SOR National Health and Medical Research Council (NHMRC) CEO Obesity Roundtable |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Participated in roundtable discussion with members of Australian Government National Health and MRC and others Raise awareness of research and IMS |
| Year(s) Of Engagement Activity | 2014 |
| Description | SOR Newsweek interview |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Raised awareness of research and IMS Recognition of article |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.newsweek.com/2015/01/30/prepare-pill-make-you-thin-301250.html |
| Description | SOR Oration at Dermatological Society |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited to give the annual oration at St John's Dermatological Society in London to a clinical audience of ~150 dermatologists and trainees. |
| Year(s) Of Engagement Activity | 2016 |
| Description | SOR Pharmacology tea club talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited to give University of Cambridge Department of Pharmacology tea club talk Raise awareness of research and of IMS |
| Year(s) Of Engagement Activity | 2014 |
| Description | SOR RTE interviews |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Raised awareness of research and IMS to the public None |
| Year(s) Of Engagement Activity | 2013 |
| Description | SOR SAC Conway |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Scientific Advisory Board None |
| Year(s) Of Engagement Activity | 2013 |
| Description | SOR SAC Crick Institute |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Scientific Advisory Board None |
| Year(s) Of Engagement Activity | 2013 |
| Description | SOR SAC Fondation Leducq |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Scientific Advisory Committee None |
| Year(s) Of Engagement Activity | 2013,2014 |
| Description | SOR Sensory Logic of the Gastronomic Brain workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Participation in workshop entitled "Sensory logic of the Gastronomic Brain" held at Basque Culinary Centre in San Sebastian, Spain. The full scientific meeting included 2.5 days with chefs and neuroscientists interacting in a workshop closed to the public. The workshop will consist in interactive discussions and experiments aiming at investigating outstanding questions related to neurogastronomy. The third day included a mini conference open to the public. The event was supported by the MRC Clinical Sciences Centre, Imperial College. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://brainytongue.com/ |
| Description | SOR SfE BES 2016 talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited to give a talk at Society for Endocrinology BES 2016 annual conference in Brighton on 'My future career in endocrinology'. |
| Year(s) Of Engagement Activity | 2016 |
| Description | SOR The Irish Times interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Recognised awareness of IMS and its research Requests for further information |
| Year(s) Of Engagement Activity | 2015 |
| URL | https://www.irishtimes.com/life-and-style/people/there-are-worse-things-in-this-world-than-being-fat... |
| Description | SOR UCD MGA presentation lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Gave presentation when awarded Medical Graduates Association Distinguished Graduate Award from University College Dublin for 2014 Raised awareness of research and IMS |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.ucd.ie/medicine/ourcommunity/ouralumni/ |
| Description | SOR University of Bristol talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Invited speaker at University of Bristol MRC IEU Seminar Series Raise awareness of research and IMS |
| Year(s) Of Engagement Activity | 2014 |
| Description | SOR University of Leuven |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Gave talk at University of Leuven, Belgium in seminar series for high profile scientists aimed at broad audience Raised awareness of research and IMS |
| Year(s) Of Engagement Activity | 2014 |
| Description | SOR University of Manchester talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited speaker at University of Manchester at Faculty's Life Science 'Leaders in Science' Lecture Series Raise awareness of research and IMS |
| Year(s) Of Engagement Activity | 2014 |
| Description | SOR University of Massachusetts Medical School Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited as Molecular Medicine Distinguished Lecturer at the University of Massachusetts Medical School, Boston, USA |
| Year(s) Of Engagement Activity | 2016 |
| Description | SOR University of the Third Age, Cambridge |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited to give talk at University of the Third Age in Cambridge Raise awareness of research and IMS |
| Year(s) Of Engagement Activity | 2014 |
| Description | TVNZ one breakfast show interview, Aug 27th 2015 |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | This live interview on New Zealand breakfast TV in support of the release of 'What's the right diet for you?' in Australia and New Zealand |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://tvnz.co.nz/breakfast-news/understanding-three-types-eaters-may-improve-diets-video-6379052 |
| Description | Talk on Public Engagement at the MRC Fellows' Symposium, London, 17/5/16 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk on public engagement to MRC Fellows at their annual symposium day in London |
| Year(s) Of Engagement Activity | 2016 |
| Description | Talk on public engagement at the NIHR summer training camp, Aschridge, 7/7/16 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk on public engagement at the NIHR summer training camp, Aschridge, 7/7/16 |
| Year(s) Of Engagement Activity | 2016 |
| Description | Talk to the Cambridge branch of 'Pint of Science', 25/5/16 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Public lecture to the Cambridge branch of 'Pint of Science' |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://pintofscience.co.uk/event/why-are-we-fat |
| Description | The Physiological Society Public Lecture Obesity: A Physiological Perspective, Newcastle United Football Club, Newcastle upon Tyne Newcastle, UK, September 10th - 12th 2014 Title 'Are your genes to blame when your jeans don't fit?' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk sparked questions and discussion afterwards Members of the public seemed genuinely stimulated in their discussions. I also had an increase in my 'twitter-following' |
| Year(s) Of Engagement Activity | 2014 |
| Description | The World Today, ABC News, Australia Obesity: now genes may be responsible for tight jeans, Maria Hatzakis reported this story on Monday, November 2, 2015 |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | This was an interview on Australia National radio on obesity. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.abc.net.au/worldtoday/content/2015/s4343585.htm |
| Description | Today FM Interview, Ireland, Jan 13th, 2015 |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | This interview on Irish radio in support of the BBC2 release of 'What's the right diet for you?' |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.todayfm.com/mobile/index.php?id=13408 |
| Description | University of Queensland Public Lecture, Brisbane, Australia, Nov 2nd 2015 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | This was the annual public lecture given as part of the University of Queensland annual post-graduate symposium. |
| Year(s) Of Engagement Activity | 2015 |
| URL | https://www.uq.edu.au/sbms/public-lecture-dr-giles-yeo-university-cambridge-are-your-genes-blame-whe... |
| Description | What's the right diet for you? Horizon special, BBC2 Jan 12-14, 2015. |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Professor Fiona Gribble and Dr Giles Yeo (me) from the MRL and MRC Metabolic Diseases Unit in Cambridge, together with colleagues Professors Susan Jebb and Paul Aveyard from Oxford, featured in a 3-part BBC2 Horizon special 'What is the right diet for you?' in Jan 2015, following the trials and tribulations of 75 overweight volunteers looking to lose weight. The programme put forward the key message that although obesity results from eating too much, the underlying influences on feeding behaviour are varied and complex, and explored whether diets could be 'tailored' to tackle these different factors. In this instance, the investigators focussed on three groups of individuals - those with a higher genetic risk of becoming obese, those with a low gut hormone rise 30mins after a meal, and those who eat in response to stress. By harnessing the power of genetics, together with biochemical and behavioural phenotyping, the programme provided a thoughtful and entertaining perspective on the current problem of obesity, and explored whether 'personalised' diets tailored to some of the root causes of overeating can succeed where more general dieting advice has failed. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.bbc.co.uk/programmes/p02ddsd9 |
| Description | Wordfest 2013, 'Thinking aloud - Obesity' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | 150 in the audience Extending the reach and improving public knowledge about obesity research |
| Year(s) Of Engagement Activity | 2013 |
| URL | http://www.cambridgewordfest.co.uk/festivals/spring/event/view/thinkingaloudobesity |
| Description | seminar at University of Santiago de Compostela, Spain |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | discussion and collaboration afterwards reshaped the content of a review paper recently published in Cell Metabolism link made for a post doc from Spain to come and spend time in our lab |
| Year(s) Of Engagement Activity | |
| Description | seminar given to Life Science Group in University of Manchester |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | met up with a number of PI in the institute to talk about the what GWAS studies mean and what kind of tools we need to move data forward also used the visit to disucss the development of a joint grant submission to tackle a project on steroid biology that combines the skills of both groups |
| Year(s) Of Engagement Activity | |
| Description | symposium on neuroendocrinology for British Society for Neuroendocrinology, British Neuroscience Association Annual Meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | a themed workshop to highlight the role of hormones and neuroendocrinology to an audience less used to thinking about the action of hormones in the brain |
| Year(s) Of Engagement Activity | 2015 |