Lipotoxicity and obesity-associated metabolic complications

Lead Research Organisation: University of Cambridge

Abstract

This programme focuses on the role of the fat tissue mediating the link between obesity, diabetes and cardiovascular problems through a mechanism involving toxic effects of fat. Specifically we aim to: a) establish mechanisms controlling how the adipose tissue grows to learn how to prevent the metabolic problems typically associated with obesity such as diabetes and heart attacks; b) to define whether targeting the brown adipose tissue, a type of fat that makes heat may prevent or reverse obesity associated complications; and c) identify diagnostic biomarkers and treatments based on patterns of lipids in mice, for subsequent confirmation in humans. These objectives will be addressed through a multidisciplinary approach that will make use of mice, state of the art in vivo and in vitro characterisation, and advanced computational systems to integrate the information.

Technical Summary

This programme focuses on the roles of adipose tissue expandability and function in mediating the link between obesity and associated metabolic complications through lipotoxic mechanisms. Specifically we aim to: a) establish mechanisms controlling adipose tissue plasticity and expansion as a strategy to prevent the development of obesity-associated metabolic complications; b) define the anti-lipotoxic effects of mitochondrial oxidation through strategies that promote the differentiation and activation of brown fat (BAT); and c) identify candidate diagnostic biomarkers and therapeutic approaches based on patterns of lipid species associated with lipotoxicity in mice, for subsequent validation in human translational studies. These objectives will be addressed through a multidisciplinary approach that will make extensive use of genetically modified murine models, state of the art in vivo and in vitro phenotyping, and systems approaches based on transcriptomic and lipidomic technologies integrated by multiple bioinformatics platforms.

Organisations

Publications

10 25 50
publication icon
Agrawal M (2019) Fat storage-inducing transmembrane protein 2 (FIT2) is less abundant in type 2 diabetes, and regulates triglyceride accumulation and insulin sensitivity in adipocytes. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology

publication icon
Bauzá-Thorbrügge M (2019) GPER and ERa mediate estradiol enhancement of mitochondrial function in inflamed adipocytes through a PKA dependent mechanism. in The Journal of steroid biochemistry and molecular biology

 
Title Development of new webb for the TVP lab 
Description tvp.mrl.ims.cam.ac.uk/ 
Type Of Art Creative Writing 
Year Produced 2013 
Impact Much broader reach attracting more visitors 
URL http://www.tvp.mrl.ims.cam.ac.uk/
 
Title TVPLAB twitter 
Description Use of Social Media TVPLAB TWITTER https://twitter.com/tvplab?lang=en-gb 
Type Of Art Creative Writing 
Year Produced 2015 
Impact Creative tool to communicate our science to public 
URL https://twitter.com/tvplab?lang=en-gb
 
Description EASO Advisory Board Meeting
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact Redefinition of obesity on the basis of body composition. BMI considered obsolete.
 
Description Editorial Activity
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact • Editorial Advisory Board: PLoS Biol (2009-) • Editorial Board Memberships: PLoS Biology (2007-), Biochemical Journal (2008-2012), Diabetes (2012-) Trends Endocrinology and Metabolism (2008-), Biochim Biophys Acta.(2012-).Guest Editor (with RH Unger) of Special issue on lipotoxicity. Biochim Biophys Acta. 2010 Mar;1801(3):207-8.
 
Description Jaime I International award panel 2017 for Clinical Medicine
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Jaime I International award panel 2017 for Clinical Medicine.
URL http://www.fprj.es/es/investigacion-medica/antoni-vidal-puig
 
Description Madrid, Spain. 20th-21 November 2019 SAB Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN)
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact SAB Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN) Strategic advice and funding allocation prioritisation
URL https://www.ciberobn.es/
 
Description Organisation of conferences/Courses
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact It is expected these training schemes have contributed to better care and scientifc developments. Member of the Scientific Organising Committee 1. Cambridge, United Kingdom. 30th June - 2nd July 2015. EAS Advanced Course in Cardiometabolic Phenotyping in Rodents. 2. Boston, USA. 5th - 9th June 2015. ADA Scientific Sessions Insulin Action/Molecular Metabolism. 3. Colorado, USA. 9th - 13th February 2015. Keystone Symposia - Systems Biology of Lipid Metabolism. 4. Madrid, Spain. 7th - 8th November 2014. CNIC Conference "Energy homeostasis and metabolic disease". 5. Madrid, Spain. 7th-8th November 2014. Energy homeostasis and metabolic disease. CNIC. 6. Cambridge, UK. 30th September 2014. 14th Annual Cambridge Immunology Forum Meeting. • Member of the Scientific Organising Committee Keystone meeting on Nuclear receptors. (http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=1235?Tab=travel) Austria (2013) • Member of the Scientific Organising Committee 15th European Congress of Endocrinology 27th April - 1st May 2013. Copenhagen, Denmark (http://www.ece2013.org/committees.aspx) • Director of The European Atherosclerosis Society Advanced Course IV: Murine Genetics and Cardiometabolic Phenotyping 11th - 14th July 2012. Cambridge, United Kingdom (http://www.eas-society.org/advanced-course-iv,-cambridge.aspx • Member of the Organising Scientific Committee of The Royal Society and Academy of Medical Sciences symposium on "Brown adipose tissue: a new human organ?" London (2012) (http://www.physoc.org/me2012) • Member of the Organising Scientific Committee The Obese Species Workshop Sicily, Italy. 21st - 26th October (2011) http://theobesespecies.unipr.it/. • Member of the Organising Scientific Committee for the meeting of the EAS in Hamburg. Germany (2010) • Member of the Organising Scientific Committee of the 49th International Conference on the Bioscience of Lipids. Maastrich (2008)
 
Description SAB scientific Advisory boards
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact Evidence of international standing • MRC College of experts (1/10/2004-30/09/2008). • MRC Physiological Systems and Clinical Sciences Board (1/10/2004-30/09/08). • MRC Funding Schemes: Survey panel (2003-2004). • International scientific advisor Spanish Research Council, Metabolism and Nutrition Node (2003-2008). • Member of the Editorial Board of PLoS Biology, Diabetes, Biochemical Journal and Trends Endocrinology and Metabolism. • Member of PLoS Biology Advisory Board (2010-) • EAS 2010 Scientific Committee • EAS Election Committee Member • Member of the Diabetes UK Research Committee • International Scientific Committee of CIBERDEM • FP7 FLORINASH Scientific Advisory Board • Committee for Severo Ochoa Research Excellence Awards of Spanish Ministry of Innovation. • IDIBAPS Scientific Advisory Board (2012-) • EASO Scientific Advisory Board (2013-) • Member of Wellcome Trust Strategic Award [Biological determinants of ageing and late life health, and their pharmacological manipulation] Scientific Advisory Board (2013-)-) • Scientific Advisory Board of Institut d'Investigacions Biomèdiques de Girona (IDIBGI) (2013-)
URL http://tvp.mrl.ims.cam.ac.uk/events/
 
Description • ERC award panel LS4 2017
Geographic Reach Europe 
Policy Influence Type Influenced training of practitioners or researchers
Impact • ERC award panel LS4 2017 Physiological sciences .
 
Description • International Scientific Advisory Board Danish Academy of Diabetes (2018-)
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact • International Scientific Advisory Board Danish Academy of Diabetes (2018-) Advice on training and research priorities.
URL https://www.danishdiabetesacademy.dk/news/dda-appoints-strong-new-international-advisory-board
 
Description 2020 Horizon Epoos
Amount € 350,000 (EUR)
Organisation European Commission 
Department Horizon 2020
Sector Public
Country European Union (EU)
Start 10/2013 
End 09/2017
 
Description Academy of Medical Sciences Clinical Lecturer Starter Grant (30,000)
Amount £30,000 (GBP)
Organisation Academy of Medical Sciences (AMS) 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2018 
End 12/2019
 
Description BHF Programme Grant no. . "Adipose tissue macrophage polarisation and lipotoxicity". 2013-2017. £933,182.00
Amount £980,000 (GBP)
Funding ID RG/12/13/29853 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2013 
End 03/2018
 
Description Cambridge-NUHS Seed Fund
Amount $35,000 (SGD)
Funding ID Study of FIT FAT 
Organisation National University Health System (NUHS) 
Sector Public
Country Singapore
Start  
 
Description ERC Senior award
Amount € 2,500,000 (EUR)
Organisation European Commission 
Department Horizon 2020
Sector Public
Country European Union (EU)
Start 01/2016 
End 12/2020
 
Description ERC senior investigator
Amount € 2,500,000 (EUR)
Funding ID StemBAT 
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 01/2015 
End 12/2020
 
Description Evelyn Fund
Amount £13,000 (GBP)
Organisation Addenbrooke's Charitable Trust (ACT) 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2014 
End 03/2015
 
Description FP7 - IMI EMIF Joint Undertaking. PI: Dr Vidal-Puig. £300,000.
Amount € 300,000 (EUR)
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 12/2014 
End 12/2016
 
Description FP7 IMI Litmus "Liver Investigation: Testing Marker Utility in Steatohepatitis" (15M euro investment of EU and >15M by EFPIA). 2017-2021. £650,000
Amount € 15,000,000 (EUR)
Funding ID FP7 IMI Litmus "Liver Investigation: Testing Marker Utility in Steatohepatitis 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2017 
End 12/2021
 
Description FP7 Litmus IMI Liver Investigation: Testing Marker Utility in Steatohepatitis
Amount € 30,000,000 (EUR)
Funding ID 777377 
Organisation European Union 
Sector Public
Country European Union (EU)
Start 11/2017 
End 10/2021
 
Description Horizon 2020 "Elucidating Pathways of Steatohepatitis (EPoS)". 2013-2017. £500,000
Amount £3,500,000 (GBP)
Organisation European Commission H2020 
Sector Public
Country Belgium
Start  
 
Description MRC MDU Programme Grant
Amount £2,000,000 (GBP)
Funding ID MRC MDU Programme Grant 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2013 
End 03/2018
 
Description Mason Medical Research Grant (15,000)
Amount £15,000 (GBP)
Organisation Mason Medical Research Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2018 
End 12/2018
 
Description NIH RO1
Amount $3,000,000 (USD)
Funding ID R01DK107786 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 09/2017 
End 06/2021
 
Description Programme grant
Amount £1,245,413 (GBP)
Funding ID RG/18/7/33636 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2018 
End 05/2023
 
Description The William Harvey International Translational Research Academy (WHRI-ACADEMY) -
Amount € 46,500 (EUR)
Funding ID 2017 Oct - 2018 Dec (15 month), 
Organisation Marie Curie 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2017 
End 12/2018
 
Title 3D Culture of Stem cells 
Description 3D tissue culture system to study cross talk between stem cells 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? No  
Impact Improvement in quality of results by better mimicking in vivo intercellular interactions. 
 
Title Citometry 
Description Development of Flow cytometry to study adipose tissue macrophages 
Type Of Material Technology assay or reagent 
Year Produced 2014 
Provided To Others? Yes  
Impact Improvement and refinement allowing decreasing the number of animals required 
 
Title Combining Stable Isotopes with calorimetry to investigate free-living nutrient utilisation in the fed state 
Description Combining Stable Isotopes with calorimetry to investigate free-living nutrient utilisation in the fed state This is an improvement in the methodology that allows us to study insulin sensitivity without radioactivity in animals that are not sedated and recapitulate more physiological conditions. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2018 
Provided To Others? Yes  
Impact Surplus fat rapidly increases fat oxidation and insulin resistance in lipodystrophic mice. Girousse A, Virtue S, Hart D, Vidal-Puig A, Murgatroyd PR, Mouisel E, Sengenès C, Savage DB. Mol Metab. 2018 Jul;13:24-29. doi: 10.1016/j.molmet.2018.05.006. Epub 2018 May 16. 
URL https://www.ncbi.nlm.nih.gov/pubmed/29789270
 
Title Development of methodology for microarray and lipidomic analysis 
Description We have contributed to develop methods for lipid analysis 
Type Of Material Technology assay or reagent 
Year Produced 2007 
Provided To Others? Yes  
Impact 1) Oresic M, H?nninen VA, Vidal-Puig A.Lipidomics: a new window to biomedical frontiers.Trends Biotechnol. 2008 Dec;26(12):647-52. Epub 2008 Oct 23PMID: 18951641 2)Tang J, Tan CY, Oresic M, Vidal-Puig A. Integrating post-genomic approaches as a strategy to advance our understanding of health and disease. Genome Med. 2009 Mar 30;1(3):35. [Epub ahead of print] PMID: 19341506 3) Yetukuri L, Ekroos K, Vidal-Puig A, Oresic M. Informatics and computational strategies for the study of lipids.Mol Biosyst. 2008 Feb;4(2):121-7. Epub 2007 Dec 18. Review. 4).Oresic M, Vidal-Puig A, H?nninen V.Metabolomic approaches to phenotype characterization and applications to complex diseases.Expert Rev Mol Diagn. 2006 Jul;6(4):575-85. Review. 
URL http://europepmc.org/abstract/MED/18951641
 
Title Development of the Phenomics center 
Description Development of three core facilities, a) Murine phenotyping, b) Murine Biochemistry and c) Murine Histopathology 
Type Of Material Improvements to research infrastructure 
Year Produced 2006 
Provided To Others? Yes  
Impact Development of MRC CORD murine metabolic programme Development and expansion vreating the Cambridge Phenomics centre. 
 
Title Differentiation of ES cells 
Description Protocols do differentiation of Human PSC to brown, white and macrophage phenotype 
Type Of Material Cell line 
Provided To Others? No  
Impact Competitiveness in our research and funding acquisition e.g. ERC grant 
 
Title Hyperinsulinaemic clamps using non stable isotopes 
Description A more accurate and refined methodology to assess tissue specific insulin resistance 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2015 
Provided To Others? Yes  
Impact Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R. Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27. PMID: 26508640 Free PMC Article Smith MA, Katsouri L, Irvine EE, Hankir MK, Pedroni SM, Voshol PJ, Gordon MW, Choudhury AI, Woods A, Vidal-Puig A, Carling D, Withers DJ.Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice.Cell Rep. 2015 Apr 21;11(3):335-43. doi: 10.1016/j.celrep.2015.03.029. Epub 2015 Apr 9. PMID: 25865886 Free PMC Article 
 
Title Mass Spectrometry to analyse lipids 
Description Refined technology to measure lipid composition. 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2015 
Provided To Others? Yes  
Impact 1. Yew Tan C, Virtue S, Murfitt S, Robert LD, Phua YH, Dale M, Griffin JL, Tinahones F, Scherer PE, Vidal-Puig A. Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance. Sci Rep. 2015 Dec 17;5:18366. doi: 10.1038/srep18366. 2. Tan CY, Virtue S, Bidault G, Dale M, Hagen R, Griffin JL, Vidal-Puig A. Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6. Cell Rep. 2015 Dec 15;13(10):2039-47. doi: 10.1016/j.celrep.2015.11.004. Epub 2015 Nov 25. 3. Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601. 
 
Title Metabolic phenotyping technology 
Description Systems of administration of lipids in vivo as a controlled system to study lipotoxicity D20 to measure fatty acid synthesis in livers of mice. 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2019 
Provided To Others? Yes  
Impact Systems for controlled administration of lipids as a controlled system to study lipotoxicity D20 to measure fatty acid synthesis in livers of mice. Both approaches are very useful to investigate the effects and localisation of specific fatty acids in vivo as well as their routes of metabolisation. This allowed dynamic studies of fluxes of lipids. 
 
Title Microarray/lipidomic data bases 
Description Microarray and lipidomic data form in vivo experiments using animal models 
Type Of Material Biological samples 
Year Produced 2007 
Provided To Others? Yes  
Impact This material has been utilised by other EU groups focused in modelling and development of tools for nutritional research 
 
Title Phenotyping of mice; Maximal thermogenic activity 
Description Protocol tomeasure maximal thermogenic capacity 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2013 
Provided To Others? Yes  
Impact Contribution to increase accuracy of murine sudies allowing refinment, and reduction of animals 
 
Title Thermogenesis related in vivo phenotyping 
Description 1) Combined Calorimetry and BAT temperature measurements at thermoneutrality 2) New Statistical methods to assess Norepinepherine turnover 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2017 
Provided To Others? Yes  
Impact Methodology allows refined evaluation of thermogenic defects originated at the CNS level by looking at the effect of the sympathetic nervous system in periphery under conditions of activation and inactivation. 
URL https://elifesciences.org/articles/22848
 
Title Tools for data quatification 
Description LEM-PCR: a method for determining relative transcript isoform proportions using real-time PCR without a standard curve.Virtue S, Dale M, Sethi JK, Vidal-Puig A. Genome. 2010 Aug;53(8):637-42. 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2010 
Provided To Others? Yes  
Impact Improved accuracy of data analysis 
 
Title b) Design a unique in house system for energy balance measurement. 
Description This is a new cageingsystem for metabolicphenotyping for simultaneous assessment of food inatke, energy expnditure, activity, water consumption. The equipment incorporates novel features such as having food delivery system hook to the cover of the cage. Also this is system is adapted to the cages where are normally hold which prevents measurement artifacts derived from changes in the cages when performing metabolic measurements. The new developed system to assess energy balance is a refinement because we can measure more accurately in each experiment. The addition of a 24h camera system with Visual Sonics software enables us to have secure systems to observe without disturbing measurements. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2010 
Provided To Others? Yes  
Impact Reduction and refinement of experiments using murine models 
 
Title metabolic Cages 
Description In collaboration with Ideas Studio, we have designed new metabolic cages (SMS cages) that monitor movement, food preference and consumption, water consumption. This caging system is set for calorimetry and has its own lighting and a camera attached so the animals can be checked without having to enter the room. This equipment represents a refinement compared to the previously used CLAM system from Columbus. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2010 
Provided To Others? Yes  
Impact This caging system is set for calorimetry and has its own lighting and a camera attached so the animals can be checked without having to enter the room. This equipment represents a refinement compared to the previously used CLAM system from Columbus. 
 
Title Bionash 
Description Data base of human liver biopsies 
Type Of Material Database/Collection of data 
Year Produced 2016 
Provided To Others? Yes  
Impact Contribution to International consortiums such fp7 Epos and FP7 IMI LItmus 
URL http://www.epos-nafld.eu/
 
Title Modelst for maximal termogenic capacity evaluation 
Description This is a novel technology to evaluate maximal capacity of energy expenditure and is the best method to evaluate defects in energy expenditure leading to obesity. 
Type Of Material Data analysis technique 
Year Produced 2015 
Provided To Others? Yes  
Impact Contributed to make research results reproducible and also contributes to 3R, 
 
Title Technology for lipidomic data analysis 
Description Development of tools for lipid analysis and integration with gene expressison analysis using multivariant analysis 
Type Of Material Data analysis technique 
Year Produced 2014 
Provided To Others? Yes  
Impact Fundamental for papers including lipidomic analysis which is central to our programme 
 
Description Bioinformatics 
Organisation EMBL European Bioinformatics Institute (EMBL - EBI)
Country United Kingdom 
Sector Academic/University 
PI Contribution Data generation in metabolic studies
Collaborator Contribution Modelling/Bioinformatic analysis
Impact Vivas, Y., C. Martinez-Garcia, A. Izquierdo, F. Garcia-Garcia, S. Callejas, (4 authors), A. Vidal-Puig, and G. Medina-Gomez, Early peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass. BMC Med Genomics, 2012. 4: p. 86. Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Prieur X, Mok CY, Velagapudi VR, Núñez V, Fuentes L, Montaner D, Ishikawa K, Camacho A, Barbarroja N, O'Rahilly S, Sethi JK, Dopazo J, Orešic M, Ricote M, Vidal-Puig A.Diabetes. 2011 Mar;60(3):797-809. doi: 10.2337/db10-0705. Epub 2011 Jan 24.MID: 21266330 Free PMC Article Razzoli M, Frontini A, Gurney A, Mondini E, Cubuk C, Katz LS, Cero C, Bolan PJ, Dopazo J, Vidal-Puig A, Cinti S, Bartolomucci A. Stress-induced activation of brown adipose tissue prevents obesity in conditions of low adaptive thermogenesis. Mol Metab. 2015 Nov 11;5(1):19-33. doi: 10.1016/j.molmet.2015.10.005. eCollection 2016 Jan. PMID: 26844204 Free PMC Article Sebastian-Leon P, Vidal E, Minguez P, Conesa A, Tarazona S, Amadoz A, Armero C, Salavert F, Vidal-Puig A, Montaner D, Dopazo J.Understanding disease mechanisms with models of signaling pathway activities. BMC Syst Biol. 2014 Oct 25;8:121. doi: 10.1186/s12918-014-0121-3.PMID: 25344409 Free PMC Article
Start Year 2011
 
Description Bioinformatics 
Organisation Regional Government of Valencia
Department Príncipe Felipe Research Centre (CIPF)
Country Spain 
Sector Academic/University 
PI Contribution Data generation in metabolic studies
Collaborator Contribution Modelling/Bioinformatic analysis
Impact Vivas, Y., C. Martinez-Garcia, A. Izquierdo, F. Garcia-Garcia, S. Callejas, (4 authors), A. Vidal-Puig, and G. Medina-Gomez, Early peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass. BMC Med Genomics, 2012. 4: p. 86. Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Prieur X, Mok CY, Velagapudi VR, Núñez V, Fuentes L, Montaner D, Ishikawa K, Camacho A, Barbarroja N, O'Rahilly S, Sethi JK, Dopazo J, Orešic M, Ricote M, Vidal-Puig A.Diabetes. 2011 Mar;60(3):797-809. doi: 10.2337/db10-0705. Epub 2011 Jan 24.MID: 21266330 Free PMC Article Razzoli M, Frontini A, Gurney A, Mondini E, Cubuk C, Katz LS, Cero C, Bolan PJ, Dopazo J, Vidal-Puig A, Cinti S, Bartolomucci A. Stress-induced activation of brown adipose tissue prevents obesity in conditions of low adaptive thermogenesis. Mol Metab. 2015 Nov 11;5(1):19-33. doi: 10.1016/j.molmet.2015.10.005. eCollection 2016 Jan. PMID: 26844204 Free PMC Article Sebastian-Leon P, Vidal E, Minguez P, Conesa A, Tarazona S, Amadoz A, Armero C, Salavert F, Vidal-Puig A, Montaner D, Dopazo J.Understanding disease mechanisms with models of signaling pathway activities. BMC Syst Biol. 2014 Oct 25;8:121. doi: 10.1186/s12918-014-0121-3.PMID: 25344409 Free PMC Article
Start Year 2011
 
Description Brown fat 
Organisation The Wenner-Gren Institute
Department Phsyiology
Country Sweden 
Sector Academic/University 
PI Contribution We have developed a new area of research focused on BAT
Collaborator Contribution Knowledge and technology
Impact Virtue S, Feldmann H, Christian M, Tan CY, Masoodi M, Dale M, Lelliott C, Burling K, Campbell M, Eguchi N, Voshol P, Sethi JK, Parker M, Urade Y, Griffin JL, Cannon B, Vidal-Puig A. A new role for Lipocalin Prostaglandin D Synthase in the regulation of brown adipose tissue substrate utilisation. Diabetes 61(12):3139-47 (2012).Virtue S, F.H., Christian M, Tan CY, Masoodi M, Dale M, et al (10 authors) Vidal-Puig A. Diabetes in press (2012), Virtue, S., M. Christian, C. Tan, M. Masoodi, M. Dale, ( 10 authors) A. Vidal-Puig, A new role for Lipocalin Prostaglandin D Synthase in the regulation of brown adipose tissue substrate utilisation. Diabetes (in press) 2012. Whittle, A.J., S. Carobbio, L. Martins, M. Slawik, E. Hondares, (11 authors),A. Vidal-Puig, BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell, 2012. 149(4): p. 871-85.
Start Year 2006
 
Description Chiba University 
Organisation Chiba University
Country Japan 
Sector Academic/University 
PI Contribution Technology and animal models
Collaborator Contribution Salary support for postdoctoral fellow
Impact 1. Diet-Induced Obese Mice and Leptin-Deficient Lepob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms. Lee E, Miedzybrodzka EL, Zhang X, Hatano R, Miyamoto J, Kimura I, Fujimoto K, Uematsu S, Rodriguez-Cuenca S, Vidal-Puig A, Gribble FM, Reimann F, Miki T. Int J Mol Sci. 2019 Sep 10;20(18). pii: E4448. doi: 10.3390/ijms20184448. PMID: 31509948 Free PMC Article Similar articles Select item 26615883 2.Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565. PMID: 26615883 Free PMC Article Similar articles Select item 26584636 3.Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A, Bujo H. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951.
Start Year 2018
 
Description Clinical Research 
Organisation University of Girona
Department Faculty of Medicine
Country Spain 
Sector Academic/University 
PI Contribution Provision of candidate genes for subsequent validation in human studies
Collaborator Contribution Access of adipose tissue bank
Impact Lagathu, C., C. Christodoulides, C.Y. Tan, S. Virtue, M. Laudes, M. (7 authors) A. Vidal-Puig, Secreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity. Int J Obes (Lond), 2010. 34(12): p. 1695-705. Rodriguez-Cuenca, S., S. Carobbio, V.R. Velagapudi, N. Barbarroja, J.M. Moreno-Navarrete,( 5 authors) A. Vidal-Puig, Peroxisome proliferator-activated receptor gamma-dependent regulation of lipolytic nodes and metabolic flexibility. Mol Cell Biol, 2012. 32(8): p. 1555-65 Kilpelainen, T.O., M.C. Zillikens, A. Stancakova, F.M. Finucane, J.S. Ried, C. Langenberg, (65 authors) A. Vidal-Puig, (40 authors) R.J. Loos, Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet, 2011. 43(8): p. 753-60. Moreno-Navarrete JM, Escoté X, Ortega F, Serino M, Campbell M, Michalski MC, Laville M, Xifra G, Luche E, Domingo P, Sabater M, Pardo G, Waget A, Salvador J, Giralt M, Rodriguez-Hermosa JI, Camps M, Kolditz CI, Viguerie N, Galitzky J, Decaunes P, Ricart W, Frühbeck G, Villarroya F, Mingrone G, Langin D, Zorzano A, Vidal H, Vendrell J, Burcelin R, Vidal-Puig A, Fernández-Real JM. A role for adipocyte-derived lipopolysaccharide-binding protein in inflammation- and obesity-associated adipose tissue dysfunction. Diabetologia 2013 Nov;56(11):2524-37 Carobbio S, Hagen RM, Lelliott CJ, Slawik M, Medina-Gomez G, Tan CY, Sicard A, Atherton HJ, Barbarroja N, Bjursell M, Bohlooly-Y M, Virtue S, Tuthill A, Lefai E, Laville M, Wu T, Considine RV, Vidal H, Langin D, Oresic M, Tinahones FJ, Fernandez-Real JM, Griffin JL, Sethi JK, López M, Vidal-Puig A. Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity. Diabetes 2013 Aug 6. [Epub ahead of print] Napolitano A, Miller SR, Murgatroyd PR, Delafont B, Brooke A, Elkhawad M, Tan CY, Virtue S, Vidal-Puig A, Nunez DJ. Prediction of Weight Loss and Regain Following Dietary, Lifestyle, and Pharmacologic Intervention. Clin Pharmacol Ther. 2012 Feb 15 Rodriguez-Cuenca S, Carobbio S, Velagapudi VR, Barbarroja N, Moreno-Navarrete JM, Tinahones FJ, Fernandez-Real JM, Oresic M, Vidal-Puig A. PPAR? DEPENDENT REGULATION OF LIPOLYTIC NODES AND METABOLIC FLEXIBILITY. Moll Cell Biol. 2012 Feb 6. Moreno-Navarrete JM, Escoté X, Ortega F, Camps M, Ricart W, Zorzano A, Vendrell J, Vidal-Puig A, Fernández-Real JM.Lipopolysaccharide binding protein is an adipokine involved in the resilience of the mouse adipocyte to inflammation. Diabetologia. 2015 Oct;58(10):2424-34. doi: 10.1007/s00125-015-3692-7. Epub 2015 Jul 23.PMID: 26201685 Ortega FJ, Serrano M, Rodriguez-Cuenca S, Moreno-Navarrete JM, Gómez-Serrano M, Sabater M, Rodriguez-Hermosa JI, Xifra G, Ricart W, Peral B, Vidal-Puig A, Fernández-Real JM. Transducin-like enhancer of split 3 (TLE3) in adipose tissue is increased in situations characterized by decreased PPAR? gene expression. J Mol Med (Berl). 2015 Jan;93(1):83-92. doi: 10.1007/s00109-014-1207-5. Epub 2014 Sep 25. PMID: 25249007 Morton NM, Beltram J, Carter RN, Michailidou Z, Gorjanc G, McFadden C, Barrios-Llerena ME, Rodriguez-Cuenca S, Gibbins MT, Aird RE, Moreno-Navarrete JM, Munger SC, Svenson KL, Gastaldello A, Ramage L, Naredo G, Zeyda M, Wang ZV, Howie AF, Saari A, Sipilä P, Stulnig TM, Gudnason V, Kenyon CJ, Seckl JR, Walker BR, Webster SP, Dunbar DR, Churchill GA, Vidal-Puig A, Fernandez-Real JM, Emilsson V, Horvat S. Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness. Nat Med. 2016 Jul;22(7):771-9. doi: 10.1038/nm.4115. Select item 31918923 Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis. Badenes M, Amin A, González-García I, Félix I, Burbridge E, Cavadas M, Ortega FJ, de Carvalho É, Faísca P, Carobbio S, Seixas E, Pedroso D, Neves-Costa A, Moita LF, Fernández-Real JM, Vidal-Puig A, Domingos A, López M, Adrain C. Mol Metab. 2020 Jan;31:67-84. doi: 10.1016/j.molmet.2019.10.006. Epub 2019 Oct 31. PMID: 31918923 Free PMC Article Cytoskeletal transgelin 2 contributes to gender-dependent adipose tissue expandability and immune function. Ortega FJ, Moreno-Navarrete JM, Mercader JM, Gómez-Serrano M, García-Santos E, Latorre J, Lluch A, Sabater M, Caballano-Infantes E, Guzmán R, Macías-González M, Buxo M, Gironés J, Vilallonga R, Naon D, Botas P, Delgado E, Corella D, Burcelin R, Frühbeck G, Ricart W, Simó R, Castrillon-Rodríguez I, Tinahones FJ, Bosch F, Vidal-Puig A, Malagón MM, Peral B, Zorzano A, Fernández-Real JM.FASEB J. 2019 Aug;33(8):9656-9671. doi: 10.1096/fj.201900479R. Epub 2019 May 30. PMID: 31145872 Peroxisome Proliferator-Activated Receptor ?2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility. Virtue S, Petkevicius K, Moreno-Navarrete JM, Jenkins B, Hart D, Dale M, Koulman A, Fernández-Real JM, Vidal-Puig A. Cell Rep. 2018 Aug 21;24(8):2005-2012.e7. doi: 10.1016/j.celrep.2018.07.063. Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness. Morton NM, Beltram J, Carter RN, Michailidou Z, Gorjanc G, McFadden C, Barrios-Llerena ME, Rodriguez-Cuenca S, Gibbins MT, Aird RE, Moreno-Navarrete JM, Munger SC, Svenson KL, Gastaldello A, Ramage L, Naredo G, Zeyda M, Wang ZV, Howie AF, Saari A, Sipilä P, Stulnig TM, Gudnason V, Kenyon CJ, Seckl JR, Walker BR, Webster SP, Dunbar DR, Churchill GA, Vidal-Puig A, Fernandez-Real JM, Emilsson V, Horvat S. Nat Med. 2016 Jul;22(7):771-9. doi: 10.1038/nm.4115. Epub 2016 Jun 6. Erratum in: Nat Med. 2018 Apr 10;24(4):525. PMID: 27270587 Free PMC Article
Start Year 2011
 
Description FAtty Liver 
Organisation EMBL European Bioinformatics Institute (EMBL - EBI)
Country United Kingdom 
Sector Academic/University 
PI Contribution Murine studies to identify NASH biomarkers and molecular mechanisms of disease. Important input from the point of lipid metabolism in macrophages and signalling in Kupffer cells and stellate cells.
Collaborator Contribution Newcastle: Leader 2020 Horizon Epoos and IMI Litmus. Access to human data EBI: Bioinformatic analysis - PhD Studetship
Impact Funding 2020 Epoos and IMIM Litmus Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in non-alcoholic fatty liver disease. Azzu V, Vacca M, Virtue S, Allison M, Vidal-Puig A. Gastroenterology. 2020 Feb 12. pii: S0016-5085(20)30224-9. doi: 10.1053/j.gastro.2019.12.054. [Epub ahead of print] PMID: 32061598 Similar articles Select item 27863448 2.Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL. Hepatology. 2017 Apr;65(4):1165-1180. doi: 10.1002/hep.28953. Epub 2017 Feb 6. PMID: 27863448 Free PMC Article Similar articles Select item 26378642 3.Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD. Vacca M, Allison M, Griffin JL, Vidal-Puig A. Semin Liver Dis. 2015 Aug;35(3):250-61. doi: 10.1055/s-0035-1562945. Epub 2015 Sep 17. Review. PMID: 26378642 Similar articles
Start Year 2016
 
Description FAtty Liver 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution Murine studies to identify NASH biomarkers and molecular mechanisms of disease. Important input from the point of lipid metabolism in macrophages and signalling in Kupffer cells and stellate cells.
Collaborator Contribution Newcastle: Leader 2020 Horizon Epoos and IMI Litmus. Access to human data EBI: Bioinformatic analysis - PhD Studetship
Impact Funding 2020 Epoos and IMIM Litmus Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in non-alcoholic fatty liver disease. Azzu V, Vacca M, Virtue S, Allison M, Vidal-Puig A. Gastroenterology. 2020 Feb 12. pii: S0016-5085(20)30224-9. doi: 10.1053/j.gastro.2019.12.054. [Epub ahead of print] PMID: 32061598 Similar articles Select item 27863448 2.Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL. Hepatology. 2017 Apr;65(4):1165-1180. doi: 10.1002/hep.28953. Epub 2017 Feb 6. PMID: 27863448 Free PMC Article Similar articles Select item 26378642 3.Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD. Vacca M, Allison M, Griffin JL, Vidal-Puig A. Semin Liver Dis. 2015 Aug;35(3):250-61. doi: 10.1055/s-0035-1562945. Epub 2015 Sep 17. Review. PMID: 26378642 Similar articles
Start Year 2016
 
Description Flies as a disease model to study metabolic disease 
Organisation German Cancer Research Center
Country Germany 
Sector Academic/University 
PI Contribution provide hypothesis for validation in flies and also perform experiments in mammalian systems with insights coming from flies.
Collaborator Contribution generation of genetically modified flies mimicking mouse or cell genetic modification.
Impact Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601. Dietary stearic acid regulates mitochondria in vivo in humans. Senyilmaz-Tiebe D, Pfaff DH, Virtue S, Schwarz KV, Fleming T, Altamura S, Muckenthaler MU, Okun JG, Vidal-Puig A, Nawroth P, Teleman AA. Nat Commun. 2018 Aug 7;9(1):3129. doi: 10.1038/s41467-018-05614-6. PMID: 30087348 Free PMC Article German Cancer Research Center (DKFZ) Serving as SAB of the
Start Year 2015
 
Description LPGD2S KO MOUSe 
Organisation Osaka University
Country Japan 
Sector Academic/University 
PI Contribution Phenotyping of mouse models
Collaborator Contribution provided animal models for MRC funded project.
Impact Papers still under submission expected to be published during 2010
Start Year 2007
 
Description Lipidomic analysis in the context of lipotoxicity 
Organisation Technical Research Centre of Finland (VTT)
Department QBIX Group
Country Finland 
Sector Private 
PI Contribution We have provided biological samples for lipidomic analysis and the intellectual background to justify this programme of research.
Collaborator Contribution The lab of Prof Matej Oresic has performed lipidomic analysis in murine tissues from our genetically modified models. Our models have provided biological material for analytical platform development. Funding forthis experiments has been provided through collaborative FP6 Hepadip and FP7 Etherpath grants. Continued collaboration with Horizon 2020 Epoos and IMI Litmus
Impact Barbarroja N, Rodriguez-Cuenca S, Nygren H, Camargo A, Pirraco A, Relat J, Cuadrado I, Pellegrinelli V, Medina-Gomez G, Lopez-Pedrera C, Tinahones FJ, Symons JD, Summers SA, Oresic M, Vidal-Puig A.Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function.Diabetes. 2015 Apr;64(4):1180-92. doi: 10.2337/db14-0359. Epub 2014 Oct 28. PMID: 25352638 Free Article << First< PrevPage of 2Next >Last >> Select item 28683288 1.Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešic M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M. Cell Metab. 2017 Jul 5;26(1):212-229.e12. doi: 10.1016/j.cmet.2017.06.014. PMID: 28683288 Free PMC Article Similar articles Select item 28104532 2.Sphingolipids and glycerophospholipids - The "ying and yang" of lipotoxicity in metabolic diseases. Rodriguez-Cuenca S, Pellegrinelli V, Campbell M, Oresic M, Vidal-Puig A. Prog Lipid Res. 2017 Apr;66:14-29. doi: 10.1016/j.plipres.2017.01.002. Epub 2017 Jan 16. Review. PMID: 28104532 Similar articles Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity. Carobbio S, Hagen RM, Lelliott CJ, Slawik M, Medina-Gomez G, Tan CY, Sicard A, Atherton HJ, Barbarroja N, Bjursell M, Bohlooly-Y M, Virtue S, Tuthill A, Lefai E, Laville M, Wu T, Considine RV, Vidal H, Langin D, Oresic M, Tinahones FJ, Fernandez-Real JM, Griffin JL, Sethi JK, López M, Vidal-Puig A.Diabetes. 2013 Nov;62(11):3697-708. doi: 10.2337/db12-1748. Epub 2013 Aug 6. PMID: 23919961 Free PMC Article Virtue S, Masoodi M, Velagapudi V, Tan CY, Dale M, Suorti T, Slawik M, Blount M, Burling K, Campbell M, Eguchi N, Medina-Gomez G, Sethi JK, Orešic M, Urade Y, Griffin JL, Vidal-PuigLipocalin prostaglandin D synthase and PPAR?2 coordinate to regulate carbohydrate and lipid metabolism in vivo.A.PLoS One. 2012;7(7):e39512. doi: 10.1371/journal.pone.0039512. Epub 2012 Jul 5. PMID: 22792179 Free PMC Article1. Prieur X, Mok CY, Velagapudi VR, Núñez V, Fuentes L, Montaner D, Ishikawa K, Camacho A, Barbarroja N, O'Rahilly S, Sethi J, Dopazo J, Oresic M, Ricote M, Vidal-Puig A. Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1 Polarization in Obese Mice. Diabetes Jan 24, 2011. Pietiläinen KH, Róg T, Seppänen-Laakso T, Virtue S, Gopalacharyulu P, Tang J, Rodriguez-Cuenca S, Maciejewski A, Naukkarinen J, Ruskeepää AL, Niemelä PS, Yetukuri L, Tan CY, Velagapudi V, Castillo S, Nygren H, Hyötyläinen T, Rissanen A, Kaprio J, Yki-Järvinen H, Vattulainen I, Vidal-Puig A, Orešic M. Association of lipidome remodelling in the adipocyte membrane with acquired obesity in humans. PLoS Biol June 7, 2011. 1.Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. 3. López M, Varela L, Vázquez MJ, Rodríguez-Cuenca S, González CR, Velagapudi VR, Morgan DA, Schoenmakers E, Agassandian K, Lage R, Martínez de Morentin PB, Tovar S, Nogueiras R, Carling D, Lelliott C, Gallego R, Oresic M, Chatterjee K, Saha AK, Rahmouni K, Diéguez C, Vidal-Puig A.Nat Med. 2010 Sep;16(9):1001-8. Epub 2010 Aug 29. PMID: 20802499 [PubMed - indexed for MEDLINE]Related citations Lagathu C, Christodoulides C, Tan CY, Virtue S, Laudes M, Campbell M, Ishikawa K, Ortega F, Tinahones FJ, Fernández-Real JM, Orešic M, Sethi JK, Vidal-Puig A.4.Secreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity. Int J Obes (Lond). 2010 Jun 1. PMID: 20514047 [PubMed - as supplied by publisher] 5.Medina-Gomez G, Yetukuri L, Velagapudi V, Campbell M, Blount M, Jimenez-Linan M, Ros M, Oresic M, Vidal-Puig A. Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome. Dis Model Mech. 2009 Nov-Dec;2(11-12):582-92. Epub 2009 Oct 19. PMID: 19841237 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text Tang J, Tan CY, Oresic M, Vidal-Puig .Integrating post-genomic approaches as a strategy to advance our understanding of health and disease. Genome Med. 2009 Mar 30;1(3):35.PMID: 19341506 [PubMed - in process]Free PMC ArticleFree text Tang J, Tan CY, Oresic M, Vidal-Puig A.Lipidomics: a new window to biomedical frontiers. Trends Biotechnol. 2008 Dec;26(12):647-52. Epub 2008 Oct 23. PMID: 18951641 [PubMed - indexed for MEDLINE] . Yetukuri L, Ekroos K, Vidal-Puig A, Oresic M.8.Informatics and computational strategies for the study of lipids Mol Biosyst. 2008 Feb;4(2):121-7. Epub 2007 Dec 18. Review. PMID: 18213405 [PubMed - indexed for MEDLINE] Related citations 9.PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GS, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M, Vidal-Puig A. PLoS Genet. 2007 Apr 27;3(4):e64. PMID: 17465682 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text Related citations 10.Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis. Yetukuri L, Katajamaa M, Medina-Gomez G, Seppänen-Laakso T, Vidal-Puig A, Oresic M. BMC Syst Biol. 2007 Feb 15;1:12. PMID: 17408502 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text Related citations 11.Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A. PLoS Biol. 2006 Nov;4(11):e369. PMID: 17090215 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text Related citations 12.Metabolomic approaches to phenotype characterization and applications to complex diseases. Oresic M, Vidal-Puig A, Hänninen V. Expert Rev Mol Diagn. 2006 Jul;6(4):575-85. Review. PMID: 16824031 [PubMed - indexed for MEDLINE] Related citations 13.Pathways to the analysis of microarray data. Curtis RK, Oresic M, Vidal-Puig A. Trends Biotechnol. 2005 Aug;23(8):429-35. Review. PMID: 15950303 [PubMed - indexed for MEDLINE] Related citations 14.The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform. 15.Medina-Gomez G, Virtue S, Lelliott C, Boiani R, Campbell M, Christodoulides C, Perrin C, Jimenez-Linan M, Blount M, Dixon J, Zahn D, Thresher RR, Aparicio S, Carlton M, Colledge WH, Kettunen MI, Seppänen-Laakso T, Sethi JK, O'Rahilly S, Brindle K, Cinti S, Oresic M, Burcelin R, Vidal-Puig A. Diabetes. 2005 Jun;54(6):1706-16. PMID: 15919792 [PubMed - indexed for MEDLINE]Free Article Related citations
 
Description Lipidomic technology 
Organisation Medical Research Council (MRC)
Department MRC Human Nutrition Research Group
Country United Kingdom 
Sector Academic/University 
PI Contribution provided intellectual framework, experimental design and biological samples.
Collaborator Contribution Providing lipidomic analysis from biological samples.
Impact 1.Medina-Gomez G, Yetukuri L, Velagapudi V, Campbell M, Blount M, Jimenez-Linan M, Ros M, Oresic M, Vidal-Puig A. Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome. Dis Model Mech. 2009 Nov-Dec;2(11-12):582-92. Epub 2009 Oct 19. PMID: 19841237 2.Tang J, Tan CY, Oresic M, Vidal-Puig A.Integrating post-genomic approaches as a strategy to advance our understanding of health and disease.Genome Med. 2009 Mar 30;1(3):35.PMID: 19341506 3.Oresic M, Hänninen VA, Vidal-Puig A.Lipidomics: a new window to biomedical frontiers. Trends Biotechnol. 2008 Dec;26(12):647-52. Epub 2008 Oct 23. PMID: 18951641 4.Yetukuri L, Ekroos K, Vidal-Puig A, Oresic M.Informatics and computational strategies for the study of lipids. Mol Biosyst. 2008 Feb;4(2):121-7. PMID: 18213405 5.Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GS, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M, Vidal-Puig A.PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism.PLoS Genet. 2007 Apr 27;3(4):e64. PMID: 17465682 6.Yetukuri L, Katajamaa M, Medina-Gomez G, Seppänen-Laakso T, Vidal-Puig A, Oresic M.Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis.BMC Syst Biol. 2007 Feb 15;1:12. PMID: 17408502 7.Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A.Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.PLoS Biol. 2006 Nov;4(11):e369.PMID: 17090215 8.Oresic M, Vidal-Puig A, Hänninen V. Metabolomic approaches to phenotype characterization and applications to complex diseases.Expert Rev Mol Diagn. 2006 Jul;6(4):575-85. Review. PMID: 16824031 15. Virtue S, F.H., Christian M, Tan CY, Masoodi M, Dale M, et al (10 authors) Vidal-Puig A. Diabetes in press (2012), A new role for Lipocalin Prostaglandin D Synthase in the regulation of brown adipose tissue substrate utilisation. Diabetes, (2012.) Virtue, S., M. Christian, C. Tan, M. Masoodi, M. Dale, C. ( 10 authors) A. Vidal-Puig, A new role for Lipocalin Prostaglandin D Synthase in the regulation of brown adipose tissue substrate utilisation. Diabetes 2012. Griffin, J.L. and A. Vidal-Puig, Current challenges in metabolomics for diabetes research: a vital functional genomic tool or just a ploy for gaining funding? Physiol Genomics, 2008. 34(1): p. 1-5. Pietilainen, K.H., T. Rog, T. Seppanen-Laakso, S. Virtue, P. Gopalacharyulu, J.(16 authors), A. Vidal-Puig, and M. Oresic, Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans. PLoS Biol, 2011. 9(6): p. e1000623. 19. Prieur, X., C.Y. Mok, V.R. Velagapudi, V. Nunez, L. Fuentes, D. (9 authors), A. Vidal-Puig, Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Diabetes, 2011. 60(3): p. 797-809. 20. Kilpelainen, T.O., M.C. Zillikens, A. Stancakova, F.M. Finucane, J.S. Ried, C. Langenberg, (65 authors) A. Vidal-Puig, (40 authors) R.J. Loos, Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet, 2011. 43(8): p. 753-60. 21. Medina-Gomez, G., L. Yetukuri, V. Velagapudi, M. Campbell, M. Blount,et al (3 authors), A. Vidal-Puig, Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome. Dis Model Mech, 2009. 2(11-12): p. 582-92. 22. Vivas, Y., C. Martinez-Garcia, A. Izquierdo, F. Garcia-Garcia, S. Callejas, (4 authors), A. Vidal-Puig, and G. Medina-Gomez, Early peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass. BMC Med Genomics, 2012. 4: p. 86. Virtue S, Feldmann H, Christian M, Tan CY, Masoodi M, Dale M, Lelliott C, Burling K, Campbell M, Eguchi N, Voshol P, Sethi JK, Parker M, Urade Y, Griffin JL, Cannon B, Vidal-Puig A. A new role for Lipocalin Prostaglandin D Synthase in the regulation of brown adipose tissue substrate utilisation. Diabetes 61(12):3139-47 (2012). 4. Carobbio S, Hagen RM, Lelliott CJ, Slawik M, Medina-Gomez G, Tan CY, Sicard A, Atherton HJ, Barbarroja N, Bjursell M, Bohlooly-Y M, Virtue S, Tuthill A, Lefai E, Laville M, Wu T, Considine RV, Vidal H, Langin D, Oresic M, Tinahones FJ, Fernandez-Real JM, Griffin JL, Sethi JK, López M, Vidal-Puig A. Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity. Diabetes 2013 Aug 6. [Epub ahead of print] 12. Virtue S, Masoodi M, Velagapudi V, Tan CY, Dale M, Suorti T, Slawik M, Blount M, Burling K, Campbell M, Eguchi N, Medina-Gomez G, Sethi JK, Orešic M, Urade Y, Griffin JL, Vidal-Puig A. Lipocalin Prostaglandin D Synthase and PPAR?2 Coordinate to Regulate Carbohydrate and Lipid Metabolism In Vivo. PLoS One 7(7):e39512. (2012) Rodriguez-Cuenca S, Carobbio S, Velagapudi VR, Barbarroja N, Moreno-Navarrete JM, Tinahones FJ, Fernandez-Real JM, Oresic M, Vidal-Puig A. PPAR? DEPENDENT REGULATION OF LIPOLYTIC NODES AND METABOLIC FLEXIBILITY. Moll Cell Biol. 2012 Feb 6.
Start Year 2006
 
Description Lipidomic technology 
Organisation Technical Research Centre of Finland (VTT)
Department Matej Oresic VTT
Country Finland 
Sector Academic/University 
PI Contribution provided intellectual framework, experimental design and biological samples.
Collaborator Contribution Providing lipidomic analysis from biological samples.
Impact 1.Medina-Gomez G, Yetukuri L, Velagapudi V, Campbell M, Blount M, Jimenez-Linan M, Ros M, Oresic M, Vidal-Puig A. Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome. Dis Model Mech. 2009 Nov-Dec;2(11-12):582-92. Epub 2009 Oct 19. PMID: 19841237 2.Tang J, Tan CY, Oresic M, Vidal-Puig A.Integrating post-genomic approaches as a strategy to advance our understanding of health and disease.Genome Med. 2009 Mar 30;1(3):35.PMID: 19341506 3.Oresic M, Hänninen VA, Vidal-Puig A.Lipidomics: a new window to biomedical frontiers. Trends Biotechnol. 2008 Dec;26(12):647-52. Epub 2008 Oct 23. PMID: 18951641 4.Yetukuri L, Ekroos K, Vidal-Puig A, Oresic M.Informatics and computational strategies for the study of lipids. Mol Biosyst. 2008 Feb;4(2):121-7. PMID: 18213405 5.Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GS, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M, Vidal-Puig A.PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism.PLoS Genet. 2007 Apr 27;3(4):e64. PMID: 17465682 6.Yetukuri L, Katajamaa M, Medina-Gomez G, Seppänen-Laakso T, Vidal-Puig A, Oresic M.Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis.BMC Syst Biol. 2007 Feb 15;1:12. PMID: 17408502 7.Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A.Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.PLoS Biol. 2006 Nov;4(11):e369.PMID: 17090215 8.Oresic M, Vidal-Puig A, Hänninen V. Metabolomic approaches to phenotype characterization and applications to complex diseases.Expert Rev Mol Diagn. 2006 Jul;6(4):575-85. Review. PMID: 16824031 15. Virtue S, F.H., Christian M, Tan CY, Masoodi M, Dale M, et al (10 authors) Vidal-Puig A. Diabetes in press (2012), A new role for Lipocalin Prostaglandin D Synthase in the regulation of brown adipose tissue substrate utilisation. Diabetes, (2012.) Virtue, S., M. Christian, C. Tan, M. Masoodi, M. Dale, C. ( 10 authors) A. Vidal-Puig, A new role for Lipocalin Prostaglandin D Synthase in the regulation of brown adipose tissue substrate utilisation. Diabetes 2012. Griffin, J.L. and A. Vidal-Puig, Current challenges in metabolomics for diabetes research: a vital functional genomic tool or just a ploy for gaining funding? Physiol Genomics, 2008. 34(1): p. 1-5. Pietilainen, K.H., T. Rog, T. Seppanen-Laakso, S. Virtue, P. Gopalacharyulu, J.(16 authors), A. Vidal-Puig, and M. Oresic, Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans. PLoS Biol, 2011. 9(6): p. e1000623. 19. Prieur, X., C.Y. Mok, V.R. Velagapudi, V. Nunez, L. Fuentes, D. (9 authors), A. Vidal-Puig, Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Diabetes, 2011. 60(3): p. 797-809. 20. Kilpelainen, T.O., M.C. Zillikens, A. Stancakova, F.M. Finucane, J.S. Ried, C. Langenberg, (65 authors) A. Vidal-Puig, (40 authors) R.J. Loos, Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet, 2011. 43(8): p. 753-60. 21. Medina-Gomez, G., L. Yetukuri, V. Velagapudi, M. Campbell, M. Blount,et al (3 authors), A. Vidal-Puig, Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome. Dis Model Mech, 2009. 2(11-12): p. 582-92. 22. Vivas, Y., C. Martinez-Garcia, A. Izquierdo, F. Garcia-Garcia, S. Callejas, (4 authors), A. Vidal-Puig, and G. Medina-Gomez, Early peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass. BMC Med Genomics, 2012. 4: p. 86. Virtue S, Feldmann H, Christian M, Tan CY, Masoodi M, Dale M, Lelliott C, Burling K, Campbell M, Eguchi N, Voshol P, Sethi JK, Parker M, Urade Y, Griffin JL, Cannon B, Vidal-Puig A. A new role for Lipocalin Prostaglandin D Synthase in the regulation of brown adipose tissue substrate utilisation. Diabetes 61(12):3139-47 (2012). 4. Carobbio S, Hagen RM, Lelliott CJ, Slawik M, Medina-Gomez G, Tan CY, Sicard A, Atherton HJ, Barbarroja N, Bjursell M, Bohlooly-Y M, Virtue S, Tuthill A, Lefai E, Laville M, Wu T, Considine RV, Vidal H, Langin D, Oresic M, Tinahones FJ, Fernandez-Real JM, Griffin JL, Sethi JK, López M, Vidal-Puig A. Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity. Diabetes 2013 Aug 6. [Epub ahead of print] 12. Virtue S, Masoodi M, Velagapudi V, Tan CY, Dale M, Suorti T, Slawik M, Blount M, Burling K, Campbell M, Eguchi N, Medina-Gomez G, Sethi JK, Orešic M, Urade Y, Griffin JL, Vidal-Puig A. Lipocalin Prostaglandin D Synthase and PPAR?2 Coordinate to Regulate Carbohydrate and Lipid Metabolism In Vivo. PLoS One 7(7):e39512. (2012) Rodriguez-Cuenca S, Carobbio S, Velagapudi VR, Barbarroja N, Moreno-Navarrete JM, Tinahones FJ, Fernandez-Real JM, Oresic M, Vidal-Puig A. PPAR? DEPENDENT REGULATION OF LIPOLYTIC NODES AND METABOLIC FLEXIBILITY. Moll Cell Biol. 2012 Feb 6.
Start Year 2006
 
Description Macrophage 
Organisation Medical Research Council (MRC)
Department MRC Laboratory of Molecular Biology (LMB)
Country United Kingdom 
Sector Academic/University 
PI Contribution Financial support for experiments and research expertise
Collaborator Contribution Research Expertise in worm models of immune disease
Impact Publciation under submission.
Start Year 2018
 
Description Mechanisms of CNS control of Energy Balance 
Organisation University of Santiago de Compostela
Country Spain 
Sector Academic/University 
PI Contribution We provide the generation and metabolic charaterisation of murine models.
Collaborator Contribution Dr Miguel Lopez was a former fellow in my lab and now has established his own lab in Santiago. He is an expert in Neuroanatomy and as such he provides his expertise to the CNS characterisation of our genetically modified mouse mopdels
Impact Whittle AJ, Carobbio S, Martins L, Slawik M, Hondares E, Vázquez MJ, Morgan D, Csikasz RI, Gallego R, Rodriguez-Cuenca S, Dale M, Virtue S, Villarroya F, Cannon B, Rahmouni K, López M, Vidal-Puig A. BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions. Cell. 2012 May 11;149(4):871-85. Carobbio S, Hagen RM, Lelliott CJ, Slawik M, Medina-Gomez G, Tan CY, Sicard A, Atherton HJ, Barbarroja N, Bjursell M, Bohlooly-Y M, Virtue S, Tuthill A, Lefai E, Laville M, Wu T, Considine RV, Vidal H, Langin D, Oresic M, Tinahones FJ, Fernandez-Real JM, Griffin JL, Sethi JK, López M, Vidal-Puig A. Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity. Diabetes 2013 Aug 6. [Epub ahead of print] Fernø J, Varela L, Skrede S, Vázquez MJ, Nogueiras R, Diéguez C, Vidal-Puig A, Steen VM, López M. Olanzapine-Induced Hyperphagia and Weight Gain Associate with Orexigenic Hypothalamic Neuropeptide Signaling without Concomitant AMPK Phosphorylation. PLoS One June 13, 2011. 2. Skrede S, Fernø J, Vázquez MJ, Fjær S, Pavlin T, Lunder N, Vidal-Puig A, Diéguez C, Berge RK, López M, Steen VM. Olanzapine, but not aripiprazole, weight-independently elevates serum triglycerides and activates lipogenic gene expression in female rats. Int J Neuropsychopharmacol. August, 2011. 3.Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. 4.López M, Varela L, Vázquez MJ, Rodríguez-Cuenca S, González CR, Velagapudi VR, Morgan DA, Schoenmakers E, Agassandian K, Lage R, Martínez de Morentin PB, Tovar S, Nogueiras R, Carling D, Lelliott C, Gallego R, Oresic M, Chatterjee K, Saha AK, Rahmouni K, Diéguez C, Vidal-Puig A. Nat Med. 2010 Sep;16(9):1001-8. Epub 2010 Aug 29. PMID: 20802499 [PubMed - indexed for MEDLINE] Related citations 5.Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender. Lage R, Vázquez MJ, Varela L, Saha AK, Vidal-Puig A, Nogueiras R, Diéguez C, López M. FASEB J. 2010 Aug;24(8):2670-9. Epub 2010 Mar 24. PMID: 20335227 [PubMed - indexed for MEDLINE] Related citations 6.AMPK: a metabolic gauge regulating whole-body energy homeostasis. Lage R, Diéguez C, Vidal-Puig A, López M. Trends Mol Med. 2008 Dec;14(12):539-49. Epub 2008 Nov 1. Review. PMID: 18977694 [PubMed - indexed for MEDLINE] Related citations 7.Brain lipogenesis and regulation of energy metabolism. López M, Vidal-Puig A. Curr Opin Clin Nutr Metab Care. 2008 Jul;11(4):483-90. Review. PMID: 18542011 [PubMed - indexed for MEDLINE] Related citations 8.Central resistin regulates hypothalamic and peripheral lipid metabolism in a nutritional-dependent fashion. 9.Vázquez MJ, González CR, Varela L, Lage R, Tovar S, Sangiao-Alvarellos S, Williams LM, Vidal-Puig A, Nogueiras R, López M, Diéguez C. Endocrinology. 2008 Sep;149(9):4534-43. Epub 2008 May 22. PMID: 18499762 [PubMed - indexed for MEDLINE]Free Article Related citations 10.Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. 11.López M, Lage R, Saha AK, Pérez-Tilve D, Vázquez MJ, Varela L, Sangiao-Alvarellos S, Tovar S, Raghay K, Rodríguez-Cuenca S, Deoliveira RM, Castañeda T, Datta R, Dong JZ, Culler M, Sleeman MW, Alvarez CV, Gallego R, Lelliott CJ, Carling D, Tschöp MH, Diéguez C, Vidal-Puig A. Cell Metab. 2008 May;7(5):389-99. PMID: 18460330 [PubMed - indexed for MEDLINE] Related citations
Start Year 2008
 
Description Mitochondria metabolism 
Organisation Mario Negri Institute for Pharmacological Research
Department Department of Pharmacology
Country Italy 
Sector Charity/Non Profit 
PI Contribution Exchange of murine models and reagents as well as intellectual exchange.
Collaborator Contribution Current collaboration on the characterisation of the effects of PGC1b in gut and liver,
Impact D'Errico I, Salvatore L, Murzilli S, Lo Sasso G, Latorre D, Martelli N, Egorova AV, Polishuck R, Madeyski-Bengtson K, Lelliott C, Vidal-Puig AJ, Seibel P, Villani G, Moschetta A. Peroxisome proliferator-activated receptor-{gamma} coactivator 1-{alpha} (PGC1{alpha}) is a metabolic regulator of intestinal epithelial cell fate. Proc Natl Acad Sci USA April 5, 2011
Start Year 2010
 
Description Molecular mechanisms of mitochondrial biogenesis 
Organisation AstraZeneca
Country United Kingdom 
Sector Private 
PI Contribution Provided biological samples for platform development
Collaborator Contribution Providing animal models generated by AZaccess to lipidomic platforms
Impact Integration in FP7 Etherpath grant
Start Year 2008
 
Description Molecular mechanisms of mitochondrial biogenesis 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution Provided biological samples for platform development
Collaborator Contribution Providing animal models generated by AZaccess to lipidomic platforms
Impact Integration in FP7 Etherpath grant
Start Year 2008
 
Description Molecular mechanisms of mitochondrial biogenesis 
Organisation Zora Biosciences Oy
Country Finland 
Sector Private 
PI Contribution Provided biological samples for platform development
Collaborator Contribution Providing animal models generated by AZaccess to lipidomic platforms
Impact Integration in FP7 Etherpath grant
Start Year 2008
 
Description NANJING/SUZHOU 
Organisation Model Animal Research Center (MARC) Nanjing
Country China 
Sector Academic/University 
PI Contribution Provide expertise in murine metabolic phenotyping
Collaborator Contribution Phenotyping of mice and PhD studentship
Impact N/A • Prof. Antonio Vidal-Puig is a concurrent professor at Nanjing University appointed in September of 2017. • A joint lab focusing on non-alcoholic fatty liver disease has been established at MARC in 2017, co-headed by Profs. Antonio Vidal-Puig and Shuai Chen. • Strong collaborative links with professor Chen Yu Zhang at the Institute of Life Sciences of the University of Nanjing to identify mechanism of disease in metabolic disorders. CYZ is one of the leaders in the development of Biology AI 3.0 in Nanjing • Prof. Antonio Vidal-Puig visits Nanjing University at least twice a year and gives lectures. • A joint workshop on metabolic diseases is to be held in May of 2019 in Nanjing. Six scientists including Prof. Antonio Vidal-Puig from Cambridge and 15 scientists from Nanjing University will attend this workshop.Nanjing, China. 19th-25th May 2019. The Sino-UK Cardiovascular disease symposium. Cambridge, United Kingdom. 5th July 2019 Joint work shop by Cambridge University Nanjing Centre of Technology and Innovation, Institute Metabolic Science, University of Cambridge, Model Animals Research Centre (MARC), University of Nanjing.
Start Year 2018
 
Description Obesity uncoupling 
Organisation Icahn School of Medicine at Mount Sinai
Country United States 
Sector Academic/University 
PI Contribution Stem cell work modelling human mutations
Collaborator Contribution Identification of human mutants relevant in obesity and cardiometabolic complications (mount Sinai). Information related to adipose tissue molecular markers in humans (INSERM) Studies in fish prioritising mutants for subsequent studies in Stem cells. Study of Lymphocytes from human adipose tissue sequence information.
Impact Multidisciplinary involving stem cell biology, genetic, zebra fish 2) NIH "Search for obesity-associated genes with protective effects on metabolic health"- Genes for healthy obesity. R01DK107786. 20 September 2017 - 30 June 2021. $415,896.05 3) Fellowship for postdoctoral fellowship
Start Year 2016
 
Description Obesity uncoupling 
Organisation UNIVER University
Country Mexico 
Sector Academic/University 
PI Contribution Stem cell work modelling human mutations
Collaborator Contribution Identification of human mutants relevant in obesity and cardiometabolic complications (mount Sinai). Information related to adipose tissue molecular markers in humans (INSERM) Studies in fish prioritising mutants for subsequent studies in Stem cells. Study of Lymphocytes from human adipose tissue sequence information.
Impact Multidisciplinary involving stem cell biology, genetic, zebra fish 2) NIH "Search for obesity-associated genes with protective effects on metabolic health"- Genes for healthy obesity. R01DK107786. 20 September 2017 - 30 June 2021. $415,896.05 3) Fellowship for postdoctoral fellowship
Start Year 2016
 
Description Obesity uncoupling 
Organisation Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Sorbonne-Paris-Cité, UMR Inserm, Paris, France
Country France 
Sector Academic/University 
PI Contribution Stem cell work modelling human mutations
Collaborator Contribution Identification of human mutants relevant in obesity and cardiometabolic complications (mount Sinai). Information related to adipose tissue molecular markers in humans (INSERM) Studies in fish prioritising mutants for subsequent studies in Stem cells. Study of Lymphocytes from human adipose tissue sequence information.
Impact Multidisciplinary involving stem cell biology, genetic, zebra fish 2) NIH "Search for obesity-associated genes with protective effects on metabolic health"- Genes for healthy obesity. R01DK107786. 20 September 2017 - 30 June 2021. $415,896.05 3) Fellowship for postdoctoral fellowship
Start Year 2016
 
Description Obesity uncoupling 
Organisation Uppsala University
Department Department of Medical Sciences
Country Sweden 
Sector Academic/University 
PI Contribution Stem cell work modelling human mutations
Collaborator Contribution Identification of human mutants relevant in obesity and cardiometabolic complications (mount Sinai). Information related to adipose tissue molecular markers in humans (INSERM) Studies in fish prioritising mutants for subsequent studies in Stem cells. Study of Lymphocytes from human adipose tissue sequence information.
Impact Multidisciplinary involving stem cell biology, genetic, zebra fish 2) NIH "Search for obesity-associated genes with protective effects on metabolic health"- Genes for healthy obesity. R01DK107786. 20 September 2017 - 30 June 2021. $415,896.05 3) Fellowship for postdoctoral fellowship
Start Year 2016
 
Description Plasticell: "In vivo activation of brown adipose tissue by plant-derived natural extracts", Innovation 
Organisation Plasticell Ltd
Country United Kingdom 
Sector Private 
PI Contribution Knowledge on mouse murine phenotyping
Collaborator Contribution Technology in conbinatorial optimisation of Stem cell differentiation.
Impact Multidisciplinary combining our unique expertise
Start Year 2017
 
Description Stem Cell Biology Valencia 
Organisation King Abdullah University of Science and Technology (KAUST)
Country Saudi Arabia 
Sector Academic/University 
PI Contribution Genetic engineering of human pluripotent stem cells
Collaborator Contribution Validation of Phenotyping of cells (CIPF). KAUST (AI Application to identify reposition of compounds) Microsoft Cambridge (Bioinformatic Analysis) Genetic engineering of Cells
Impact Generation of gene-corrected human induced pluripotent stem cell lines derived from retinitis pigmentosa patient with Ser331Cysfs*5 mutation in MERTK. Artero Castro A, Long K, Bassett A, Machuca C, León M, Ávila-Fernandez A, Cortón M, Vidal-Puig T, Ayuso C, Lukovic D, Erceg S. Stem Cell Res. 2019 Jan;34:101341. doi: 10.1016/j.scr.2018.11.003. Epub 2018 Nov 16. PMID: 30612079 Free Article
Start Year 2017
 
Description Stem Cell Biology Valencia 
Organisation Linkoping University
Department Regenerative Medicine
Country Sweden 
Sector Academic/University 
PI Contribution Genetic engineering of human pluripotent stem cells
Collaborator Contribution Validation of Phenotyping of cells (CIPF). KAUST (AI Application to identify reposition of compounds) Microsoft Cambridge (Bioinformatic Analysis) Genetic engineering of Cells
Impact Generation of gene-corrected human induced pluripotent stem cell lines derived from retinitis pigmentosa patient with Ser331Cysfs*5 mutation in MERTK. Artero Castro A, Long K, Bassett A, Machuca C, León M, Ávila-Fernandez A, Cortón M, Vidal-Puig T, Ayuso C, Lukovic D, Erceg S. Stem Cell Res. 2019 Jan;34:101341. doi: 10.1016/j.scr.2018.11.003. Epub 2018 Nov 16. PMID: 30612079 Free Article
Start Year 2017
 
Description Stem Cell Biology Valencia 
Organisation Microsoft Research
Department Microsoft Research Cambridge
Country United Kingdom 
Sector Private 
PI Contribution Genetic engineering of human pluripotent stem cells
Collaborator Contribution Validation of Phenotyping of cells (CIPF). KAUST (AI Application to identify reposition of compounds) Microsoft Cambridge (Bioinformatic Analysis) Genetic engineering of Cells
Impact Generation of gene-corrected human induced pluripotent stem cell lines derived from retinitis pigmentosa patient with Ser331Cysfs*5 mutation in MERTK. Artero Castro A, Long K, Bassett A, Machuca C, León M, Ávila-Fernandez A, Cortón M, Vidal-Puig T, Ayuso C, Lukovic D, Erceg S. Stem Cell Res. 2019 Jan;34:101341. doi: 10.1016/j.scr.2018.11.003. Epub 2018 Nov 16. PMID: 30612079 Free Article
Start Year 2017
 
Description Thermogenesis 
Organisation Chiba University
Country Japan 
Sector Academic/University 
PI Contribution Murine generation and Phenotyping
Collaborator Contribution Specific Thermogenic studies covering CNS, BAT and electrophysiology
Impact Whittle, A.J., S. Carobbio, L. Martins, M. Slawik, E. Hondares, (11 authors),A. Vidal-Puig, BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell, 2012. 149(4): p. 871-85. Lopez, M., R. Lage, A.K. Saha, D. Perez-Tilve, M.J. Vazquez, (17 authors), A. Vidal-Puig, Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab, 2008. 7(5): p. 389-99. Lopez, M., L. Varela, M.J. Vazquez, S. Rodriguez-Cuenca, C.R. Gonzalez,(16 authors) and A. Vidal-Puig, Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med, 2010. 16(9): p. 1001-8. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565. 4. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A*, Bujo H*. Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951.* Corresponding Author Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27 Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601 . Transforming Growth Factor-ß3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue. Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado E, Kulyté A, Lopez Y, Campbell M, Acosta JR, Laurencikiene J, Douagi I, Gao H, Martínez-Álvarez C, Hedén P, Spalding KL, Vidal-Puig A, Medina-Gomez G, Arner P, Rydén M. Cell Rep. 2018 Oct 16;25(3):551-560.e5. doi: 10.1016/j.celrep.2018.09.069. PMID: 30332637 Free Article Similar articles
Start Year 2010
 
Description Thermogenesis 
Organisation German Cancer Research Center
Country Germany 
Sector Academic/University 
PI Contribution Murine generation and Phenotyping
Collaborator Contribution Specific Thermogenic studies covering CNS, BAT and electrophysiology
Impact Whittle, A.J., S. Carobbio, L. Martins, M. Slawik, E. Hondares, (11 authors),A. Vidal-Puig, BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell, 2012. 149(4): p. 871-85. Lopez, M., R. Lage, A.K. Saha, D. Perez-Tilve, M.J. Vazquez, (17 authors), A. Vidal-Puig, Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab, 2008. 7(5): p. 389-99. Lopez, M., L. Varela, M.J. Vazquez, S. Rodriguez-Cuenca, C.R. Gonzalez,(16 authors) and A. Vidal-Puig, Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med, 2010. 16(9): p. 1001-8. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565. 4. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A*, Bujo H*. Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951.* Corresponding Author Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27 Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601 . Transforming Growth Factor-ß3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue. Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado E, Kulyté A, Lopez Y, Campbell M, Acosta JR, Laurencikiene J, Douagi I, Gao H, Martínez-Álvarez C, Hedén P, Spalding KL, Vidal-Puig A, Medina-Gomez G, Arner P, Rydén M. Cell Rep. 2018 Oct 16;25(3):551-560.e5. doi: 10.1016/j.celrep.2018.09.069. PMID: 30332637 Free Article Similar articles
Start Year 2010
 
Description Thermogenesis 
Organisation Stockholm University
Department Werner Institute
Country Sweden 
Sector Academic/University 
PI Contribution Murine generation and Phenotyping
Collaborator Contribution Specific Thermogenic studies covering CNS, BAT and electrophysiology
Impact Whittle, A.J., S. Carobbio, L. Martins, M. Slawik, E. Hondares, (11 authors),A. Vidal-Puig, BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell, 2012. 149(4): p. 871-85. Lopez, M., R. Lage, A.K. Saha, D. Perez-Tilve, M.J. Vazquez, (17 authors), A. Vidal-Puig, Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab, 2008. 7(5): p. 389-99. Lopez, M., L. Varela, M.J. Vazquez, S. Rodriguez-Cuenca, C.R. Gonzalez,(16 authors) and A. Vidal-Puig, Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med, 2010. 16(9): p. 1001-8. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565. 4. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A*, Bujo H*. Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951.* Corresponding Author Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27 Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601 . Transforming Growth Factor-ß3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue. Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado E, Kulyté A, Lopez Y, Campbell M, Acosta JR, Laurencikiene J, Douagi I, Gao H, Martínez-Álvarez C, Hedén P, Spalding KL, Vidal-Puig A, Medina-Gomez G, Arner P, Rydén M. Cell Rep. 2018 Oct 16;25(3):551-560.e5. doi: 10.1016/j.celrep.2018.09.069. PMID: 30332637 Free Article Similar articles
Start Year 2010
 
Description Thermogenesis 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Murine generation and Phenotyping
Collaborator Contribution Specific Thermogenic studies covering CNS, BAT and electrophysiology
Impact Whittle, A.J., S. Carobbio, L. Martins, M. Slawik, E. Hondares, (11 authors),A. Vidal-Puig, BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell, 2012. 149(4): p. 871-85. Lopez, M., R. Lage, A.K. Saha, D. Perez-Tilve, M.J. Vazquez, (17 authors), A. Vidal-Puig, Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab, 2008. 7(5): p. 389-99. Lopez, M., L. Varela, M.J. Vazquez, S. Rodriguez-Cuenca, C.R. Gonzalez,(16 authors) and A. Vidal-Puig, Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med, 2010. 16(9): p. 1001-8. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565. 4. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A*, Bujo H*. Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951.* Corresponding Author Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27 Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601 . Transforming Growth Factor-ß3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue. Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado E, Kulyté A, Lopez Y, Campbell M, Acosta JR, Laurencikiene J, Douagi I, Gao H, Martínez-Álvarez C, Hedén P, Spalding KL, Vidal-Puig A, Medina-Gomez G, Arner P, Rydén M. Cell Rep. 2018 Oct 16;25(3):551-560.e5. doi: 10.1016/j.celrep.2018.09.069. PMID: 30332637 Free Article Similar articles
Start Year 2010
 
Description Thermogenesis 
Organisation Toho University
Country Japan 
Sector Academic/University 
PI Contribution Murine generation and Phenotyping
Collaborator Contribution Specific Thermogenic studies covering CNS, BAT and electrophysiology
Impact Whittle, A.J., S. Carobbio, L. Martins, M. Slawik, E. Hondares, (11 authors),A. Vidal-Puig, BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell, 2012. 149(4): p. 871-85. Lopez, M., R. Lage, A.K. Saha, D. Perez-Tilve, M.J. Vazquez, (17 authors), A. Vidal-Puig, Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab, 2008. 7(5): p. 389-99. Lopez, M., L. Varela, M.J. Vazquez, S. Rodriguez-Cuenca, C.R. Gonzalez,(16 authors) and A. Vidal-Puig, Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med, 2010. 16(9): p. 1001-8. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565. 4. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A*, Bujo H*. Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951.* Corresponding Author Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27 Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601 . Transforming Growth Factor-ß3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue. Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado E, Kulyté A, Lopez Y, Campbell M, Acosta JR, Laurencikiene J, Douagi I, Gao H, Martínez-Álvarez C, Hedén P, Spalding KL, Vidal-Puig A, Medina-Gomez G, Arner P, Rydén M. Cell Rep. 2018 Oct 16;25(3):551-560.e5. doi: 10.1016/j.celrep.2018.09.069. PMID: 30332637 Free Article Similar articles
Start Year 2010
 
Description Thermogenesis 
Organisation University of Graz
Department Institute of Molecular Biosciences
Country Austria 
Sector Academic/University 
PI Contribution Murine generation and Phenotyping
Collaborator Contribution Specific Thermogenic studies covering CNS, BAT and electrophysiology
Impact Whittle, A.J., S. Carobbio, L. Martins, M. Slawik, E. Hondares, (11 authors),A. Vidal-Puig, BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell, 2012. 149(4): p. 871-85. Lopez, M., R. Lage, A.K. Saha, D. Perez-Tilve, M.J. Vazquez, (17 authors), A. Vidal-Puig, Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab, 2008. 7(5): p. 389-99. Lopez, M., L. Varela, M.J. Vazquez, S. Rodriguez-Cuenca, C.R. Gonzalez,(16 authors) and A. Vidal-Puig, Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med, 2010. 16(9): p. 1001-8. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565. 4. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A*, Bujo H*. Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951.* Corresponding Author Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27 Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601 . Transforming Growth Factor-ß3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue. Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado E, Kulyté A, Lopez Y, Campbell M, Acosta JR, Laurencikiene J, Douagi I, Gao H, Martínez-Álvarez C, Hedén P, Spalding KL, Vidal-Puig A, Medina-Gomez G, Arner P, Rydén M. Cell Rep. 2018 Oct 16;25(3):551-560.e5. doi: 10.1016/j.celrep.2018.09.069. PMID: 30332637 Free Article Similar articles
Start Year 2010
 
Description Thermogenesis 
Organisation University of Minnesota
Department Department of Integrative Biology and Physiology
Country United States 
Sector Academic/University 
PI Contribution Murine generation and Phenotyping
Collaborator Contribution Specific Thermogenic studies covering CNS, BAT and electrophysiology
Impact Whittle, A.J., S. Carobbio, L. Martins, M. Slawik, E. Hondares, (11 authors),A. Vidal-Puig, BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell, 2012. 149(4): p. 871-85. Lopez, M., R. Lage, A.K. Saha, D. Perez-Tilve, M.J. Vazquez, (17 authors), A. Vidal-Puig, Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab, 2008. 7(5): p. 389-99. Lopez, M., L. Varela, M.J. Vazquez, S. Rodriguez-Cuenca, C.R. Gonzalez,(16 authors) and A. Vidal-Puig, Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med, 2010. 16(9): p. 1001-8. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565. 4. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A*, Bujo H*. Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951.* Corresponding Author Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27 Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601 . Transforming Growth Factor-ß3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue. Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado E, Kulyté A, Lopez Y, Campbell M, Acosta JR, Laurencikiene J, Douagi I, Gao H, Martínez-Álvarez C, Hedén P, Spalding KL, Vidal-Puig A, Medina-Gomez G, Arner P, Rydén M. Cell Rep. 2018 Oct 16;25(3):551-560.e5. doi: 10.1016/j.celrep.2018.09.069. PMID: 30332637 Free Article Similar articles
Start Year 2010
 
Description Thermogenesis 
Organisation University of Newcastle
Country Australia 
Sector Academic/University 
PI Contribution Murine generation and Phenotyping
Collaborator Contribution Specific Thermogenic studies covering CNS, BAT and electrophysiology
Impact Whittle, A.J., S. Carobbio, L. Martins, M. Slawik, E. Hondares, (11 authors),A. Vidal-Puig, BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell, 2012. 149(4): p. 871-85. Lopez, M., R. Lage, A.K. Saha, D. Perez-Tilve, M.J. Vazquez, (17 authors), A. Vidal-Puig, Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab, 2008. 7(5): p. 389-99. Lopez, M., L. Varela, M.J. Vazquez, S. Rodriguez-Cuenca, C.R. Gonzalez,(16 authors) and A. Vidal-Puig, Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med, 2010. 16(9): p. 1001-8. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565. 4. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A*, Bujo H*. Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951.* Corresponding Author Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27 Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601 . Transforming Growth Factor-ß3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue. Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado E, Kulyté A, Lopez Y, Campbell M, Acosta JR, Laurencikiene J, Douagi I, Gao H, Martínez-Álvarez C, Hedén P, Spalding KL, Vidal-Puig A, Medina-Gomez G, Arner P, Rydén M. Cell Rep. 2018 Oct 16;25(3):551-560.e5. doi: 10.1016/j.celrep.2018.09.069. PMID: 30332637 Free Article Similar articles
Start Year 2010
 
Description Thermogenesis 
Organisation University of Santiago de Compostela
Department Physiology
Country Spain 
Sector Academic/University 
PI Contribution Murine generation and Phenotyping
Collaborator Contribution Specific Thermogenic studies covering CNS, BAT and electrophysiology
Impact Whittle, A.J., S. Carobbio, L. Martins, M. Slawik, E. Hondares, (11 authors),A. Vidal-Puig, BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell, 2012. 149(4): p. 871-85. Lopez, M., R. Lage, A.K. Saha, D. Perez-Tilve, M.J. Vazquez, (17 authors), A. Vidal-Puig, Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab, 2008. 7(5): p. 389-99. Lopez, M., L. Varela, M.J. Vazquez, S. Rodriguez-Cuenca, C.R. Gonzalez,(16 authors) and A. Vidal-Puig, Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med, 2010. 16(9): p. 1001-8. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565. 4. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A*, Bujo H*. Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951.* Corresponding Author Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27 Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601 . Transforming Growth Factor-ß3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue. Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado E, Kulyté A, Lopez Y, Campbell M, Acosta JR, Laurencikiene J, Douagi I, Gao H, Martínez-Álvarez C, Hedén P, Spalding KL, Vidal-Puig A, Medina-Gomez G, Arner P, Rydén M. Cell Rep. 2018 Oct 16;25(3):551-560.e5. doi: 10.1016/j.celrep.2018.09.069. PMID: 30332637 Free Article Similar articles
Start Year 2010
 
Description Univerisdad de Barcelona- 
Organisation University of Barcelona
Country Spain 
Sector Academic/University 
PI Contribution Provide genetically modified murine models and technological support for phenotyping
Collaborator Contribution Specific knowledge in the analysis of CPT1 mutants. This is a very specific type of specialised knowledge that provides us with competitive advantage
Impact 1. P465L-PPAR? mutation confers partial resistance to the hypolipidaemic action of fibrates. Rodriguez-Cuenca S, Carobbio S, Barceló-Coblijn G, Prieur X, Relat J, Amat R, Campbell M, Dias AR, Bahri M, Gray SL, Vidal-Puig A. Diabetes Obes Metab. 2018 Oct;20(10):2339-2350. doi: 10.1111/dom.13370. Epub 2018 Jun 27. PMID: 29790245 Free PMC Article Similar articles Select item 26584636 Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A, Bujo H. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951. PMID: 26584636 Free PMC Article Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function. Barbarroja N, Rodriguez-Cuenca S, Nygren H, Camargo A, Pirraco A, Relat J, Cuadrado I, Pellegrinelli V, Medina-Gomez G, Lopez-Pedrera C, Tinahones FJ, Symons JD, Summers SA, Oresic M, Vidal-Puig A. Diabetes. 2015 Apr;64(4):1180-92. doi: 10.2337/db14-0359. Epub 2014 Oct 28. PMID: 25352638 Free Article Trends Pharmacol Sci. 2013 Jun;34(6):347-55. doi: 10.1016/j.tips.2013.04.004. Epub 2013 May 3. Pharmacological strategies for targeting BAT thermogenesis. Whittle A1, Relat-Pardo J, Vidal-Puig A.
Start Year 2018
 
Description kidney Lipotoxicity 
Organisation Rey Juan Carlos University Hospital
Country Spain 
Sector Hospitals 
PI Contribution Provided animal models to study Kidney lipotoxicity
Collaborator Contribution Provided expertise in murine characterisation of kidney phenotypes.
Impact Transforming Growth Factor-ß3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue. Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado E, Kulyté A, Lopez Y, Campbell M, Acosta JR, Laurencikiene J, Douagi I, Gao H, Martínez-Álvarez C, Hedén P, Spalding KL, Vidal-Puig A, Medina-Gomez G, Arner P, Rydén M. Cell Rep. 2018 Oct 16;25(3):551-560.e5. doi: 10.1016/j.celrep.2018.09.069. PMID: 30332637 Free Article 2.PPARs and Metabolic Disorders Associated with Challenged Adipose Tissue Plasticity. Corrales P, Vidal-Puig A, Medina-Gómez G. Int J Mol Sci. 2018 Jul 21;19(7). pii: E2124. doi: 10.3390/ijms19072124. Review. PMID: 30037087 Free PMC Article 3. Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešic M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M. Cell Metab. 2017 Jul 5;26(1):212-229.e12. doi: 10.1016/j.cmet.2017.06.014. PMID: 28683288 F
Start Year 2019
 
Description macrophage 
Organisation National Center for Cardiovascular Research (CNIC)
Country Spain 
Sector Academic/University 
PI Contribution Generation of original mouse models and characterisation
Collaborator Contribution Generation of murine models targeting specific genetic modification to macrophages
Impact Prieur, X., C.Y. Mok, V.R. Velagapudi, V. Nunez, L. Fuentes, D. (9 authors), A. Vidal-Puig, Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Diabetes, 2011. 60(3): p. 797-809. Virtue S, Masoodi M, de Weijer BA, van Eijk M, Mok CY, Eiden M, Dale M, Pirraco A, Serlie MJ, Griffin JL, Vidal-Puig A. Prostaglandin profiling reveals a role for haematopoietic prostaglandin D synthase in adipose tissue macrophage polarisation in mice and humans. Int J Obes (Lond). 2015 Mar 24. doi: 10.1038/ijo.2015.34
Start Year 2011
 
Description macrophage 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Generation of original mouse models and characterisation
Collaborator Contribution Generation of murine models targeting specific genetic modification to macrophages
Impact Prieur, X., C.Y. Mok, V.R. Velagapudi, V. Nunez, L. Fuentes, D. (9 authors), A. Vidal-Puig, Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Diabetes, 2011. 60(3): p. 797-809. Virtue S, Masoodi M, de Weijer BA, van Eijk M, Mok CY, Eiden M, Dale M, Pirraco A, Serlie MJ, Griffin JL, Vidal-Puig A. Prostaglandin profiling reveals a role for haematopoietic prostaglandin D synthase in adipose tissue macrophage polarisation in mice and humans. Int J Obes (Lond). 2015 Mar 24. doi: 10.1038/ijo.2015.34
Start Year 2011
 
Description Bavarian Alps, Germany. 25th-27th September 2019. AMPro Summer School for PhD Students & Postdocs. Aging and Metabolic Programming. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact Bavarian Alps, Germany. 25th-27th September 2019. AMPro Summer School for PhD Students & Postdocs. Aging and Metabolic Programming.

PhD programme related to the German Centre of Cancer where I serve as SAAB
Year(s) Of Engagement Activity 2019
URL https://ampro.helmholtz-muenchen.de/news-events/past-events/ampro-summer-school-2019/index.html
 
Description Brussels, Belgium. 18th- 21st June 2019. European Research Council -2019-STG - LS4, Step 2. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Brussels, Belgium. 18th- 21st June 2019. European Research Council -2019-STG - LS4, Step 2.
This was an event where we selected the awardees of ERC starting grants
Year(s) Of Engagement Activity 2019
URL https://erc.europa.eu/document-category/evaluation-panels
 
Description 12th National Congress of the Spanish Society for the Study of Obesity. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact 12th National Congress of the Spanish Society for the Study of Obesity.
Year(s) Of Engagement Activity 2015
 
Description 36 Congreso Sociedad Española de Farmacología. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact http://congresosef2015.com/programa-cientifico/esquema-del-programa/
12:30 - 13:30
Sesión Plenaria.

Moderadora: Dra. Mª Jesús Sanz Ferrando
Universitat de València.
Adipose tissue expandability, lipotoxicity and the metabolic syndrome.
Prof. Antonio Vidal Puig University of Cambridge. Reino Unido.
Year(s) Of Engagement Activity 2015
URL http://congresosef2015.com/programa-cientifico/esquema-del-programa/
 
Description 5th - 9th June 2015. ADA Scientific Sessions Insulin Action/Molecular Metabolism. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lecture American Diabetes Association Conference 2015
Year(s) Of Engagement Activity 2015
URL http://professional2.diabetes.org/Presentations_Details.aspx?typ=10&sr=adv&cgr=238&congress=238
 
Description Alabama, USA. 19th November 2013. University of Alabama at Birmingham, Nutrition Obesity Research Center - NORC's Noon Seminar Series. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The seminar is sponsored by the Nutrition Obesity Research Center and co-sponsored by the Department of Nutrition Sciences.
Addressed the problem of adipose tissue expandability and metabolic syndrome
Year(s) Of Engagement Activity 2013
URL http://www.norc.uab.edu/courses/seminars/seminar2013#
 
Description Bilbao, Spain. 1st March 2017. Seminar at Biofisika, Basque Centre for Biophysics. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Bilbao, Spain. 1st March 2017. Seminar at Biofisika, Basque Centre for Biophysics. Lecture. Networking with engineers.
Year(s) Of Engagement Activity 2017
URL http://biofisika.org/
 
Description British Atherosclerosis Society Meeting: 'Atherosclerosis: crossroads of metabolism and inflammation'. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact British Atherosclerosis Society Meeting: 'Atherosclerosis: crossroads of metabolism and inflammation'.
British Atherosclerosis Society Autumn Meeting 2015


Atherosclerosis: Crossroads of Metabolism and Inflammation

Meeting Report

Organisers: Joseph Boyle, Ashley Miller, Martin Bennett
Date: Thursday 10th - Friday 11th September 2015
Venue: Murray Edwards College, New Hall, University of Cambridge, Cambridge
Final Programme
Sponsors: Amgen has provided unrestricted funding to support this meeting. Amgen has had no input into the programme, selection of speakers or topics.
Year(s) Of Engagement Activity 2015
URL http://www.britathsoc.org/previous-meetings/british-atherosclerosis-society-autumn-meeting-2015/
 
Description CNIC Conference "Energy homeostasis and metabolic disease" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation workshop facilitator
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 7th - 8th November 2014. CNIC Conference "Energy homeostasis and metabolic disease"
Madrid, Spain
Organisers: Mercedes Ricote, Guadalupe Sabio, Antonio Vidal-Puig
150 attendants

International visibility
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk/upcoming-conferences-organised-by-prof-vidal-puig/
 
Description Colorado, USA. 9th - 13th February 2015. Keystone Symposia - Systems Biology of Lipid Metabolism. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keystone Symposia organiser and speaker.
Area Lipid Biochemistry
Year(s) Of Engagement Activity 2015
URL http://www.keystonesymposia.org/15B4
 
Description Dusseldorf, Germany. 10th October 2017. Universitäts Klinikum Lecture Series - CRC1116 "master switches after myocardial infarction" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Dusseldorf, Germany. 10th October 2017. Universitäts Klinikum Lecture Series - CRC1116 "master switches after myocardial infarction"
Year(s) Of Engagement Activity 2017
URL http://www.irtg1902.hhu.de/schedule/schedule-single-view.html?tx_cal_controller%5Bgetdate%5D=2017101...
 
Description EAS Advanced Course in Cardiometabolic Phenotyping in Rodents. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact EAS Advanced in Cardiometabolic Phenotyping in Rodents, Cambridge, UK

Scientists from the University of Cambridge Biomedical Campus recently hosted the 2nd EAS Advanced Course in Cardiometabolic Phenotyping in Rodents. This 3-day course combines the state of the art facilities and expertise within the Disease Model Core at the WellcomeTrust-MRC Institute of Metabolic Science and the BHF Cardiovascular Centre. By integrating the expertise of these two specialized phenotyping centres, it provides a unique opportunity to learn about many of the skills required for in depth cardiometabolic phenotyping in small animals.

The 32 participants, selected from centres across Europe, were treated to a programme of lectures, phenotyping demonstrations and data analysis sessions. A further 1-day workshop at the Sanger/EBI focused on mouse genetics, genetic engineering and informatics resources, highlighting the great opportunities provided by recent advances in genetic engineering purpose-made mouse models. Participants particularly appreciated the mixture of hands-on experience, combined with opportunities to ask detailed questions on how the techniques demonstrated should be used to suit their own research priorities.

The course was sponsored by the European Atherosclerosis Society, British Heart Foundation and TSE systems, with organisation led by Prof Toni Vidal-Puig, Director of the MRC Metabolic Diseases Unit Disease Model Core.
Year(s) Of Engagement Activity 2015
URL http://tvp.mrl.ims.cam.ac.uk/events/
 
Description European Neuroendocrinology Society meeting in Vienna. . 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Dr Sam Virtue recently presented at the prestigious European Neuroendocrinology Society meeting in Vienna. Sam's talk was focussed on metabolomics in endocrinology and was based on the past 9 years of experience in the TVP lab in the field of lipodomics. The purpose of the talk was to discuss how biologists without systems biology experience can work with groups specialising in the fields of metabolomics to design appropriate experiments and extract the maximum value from their data sets.

Dr Virtue has been invivted to give similar type of talk in other venues,
Year(s) Of Engagement Activity 2012
 
Description Keystone Symposia on Diabetes/Obesity and Adipose Tissue Biology. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Keystone Conference Lecture. Colorado, USA. 22nd - 27th January 2017.
Year(s) Of Engagement Activity 2017
URL http://healthdocbox.com/amp/69735120-Diabetes/Diabetes-january-22-26-2017-keystone-conference-center...
 
Description Keystone Symposia on Diabetes/Obesity and Adipose Tissue Biology. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact . Colorado, USA. 22nd - 27th January 2017. Keystone Symposia on Diabetes/Obesity and Adipose Tissue Biology.
Year(s) Of Engagement Activity 2016
 
Description Lisbon, Portugal. 11th-15th September 2017. 53rd EASD Annual Meeting. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Lisbon, Portugal. 11th-15th September 2017. 53rd EASD Annual Meeting. >150 attendants to symposium on Obesity associated metabolic complications.
Year(s) Of Engagement Activity 2017
URL https://d-net.idf.org/en/events/369-53rd-easd-annual-meeting-in-lisbon-portugal.html
 
Description London, UK. 24th April 2015. Royal Society of Medicine Symposium. Obesity: Epidemiology, complications and management. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This symposium provided a multidisciplinary forum for researchers and healthcare workers to discuss the most recent advances, trends and management challenges encountered in the field of obesity.

Throughout the day, delegates explored the opportunities and challenges faced by those involved in obesity medicine, together with the solutions that have currently been adopted.

The symposium aimed at all those working in the field or with an interest in obesity medicine, vascular risk medicine, PhD students, post-doctoral researchers, and clinicians of all medical specialties including medical students, foundation and core trainees, general practitioners, physicians and surgeons.
Year(s) Of Engagement Activity 2015
URL https://www.rsm.ac.uk/events/events-listing/2014-2015/sections/lipids,-metabolism-vascular-risk-sect...
 
Description Majorca, Spain. 16th October 2017. Seminar at Illes Balears Institute for Health Research. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Majorca, Spain. 16th October 2017. Seminar at Illes Balears Institute for Health Research. Research seminar. >80 attendees.
Year(s) Of Engagement Activity 2017
URL https://www.arabalears.cat/balears/Antonio-Vidal-Puig-nostres-estalviadors-lluitar_0_1892210855.html
 
Description Mexico. 13th-14th February 2019. Nutrition Forum 2019 Danone Institute of Mexico. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on obesity and nutrition
Year(s) Of Engagement Activity 2018
URL https://www.danoneinstitute.org/nutrition-health/local-initiatives
 
Description Naples, Italy. 28th May 2018. Seminar at The Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" of the National Research Council (CNR). 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Naples, Italy. 28th May 2018. Seminar at The Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" of the National Research Council (CNR). Lecture on the Adipose tissue expandability, lipotoxicity and metabolic syndrome.
Year(s) Of Engagement Activity 2018
 
Description Tokyo, Japan. 18th July 2013. Special lecture at Toho University Medical Center 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Professor Toni Vidal-Puig visits the lab of Professor Hideaki Bujo at Toho University in Japan as part of their collaborative research programme on brown fat differentiation.
Year(s) Of Engagement Activity 2013
URL http://tvp.mrl.ims.cam.ac.uk/events/
 
Description Utah, USA. 17th - 22nd April 2015. Keystone Symposium - Beige and Brown Fat: Basic Biology and Novel Therapeutics. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Beige and Brown Fat: Basic Biology and Novel Therapeutics (D5)
Organizer(s) Bruce M. Spiegelman and Sven Enerbäck
April 17-22, 2015
Snowbird Resort • Snowbird, Utah USA
The epidemic of obesity and diabetes has become a world-wide health risk. These metabolic disorders are a direct threat to the health and economic well-being of many nations. Unfortunately, education about diet and exercise are not sufficient to meet this emergency and new therapies are badly needed. Brown fat has emerged as one of the few genuinely new approaches to these problems. Brown fat exists in most or all adult humans and can dissipate caloric energy and improve both obesity and diabetes in experimental animals. This meeting will focus on new pathways controlling brown fat development and thermogenesis. We will delve into the types of brown fat cells, beige, classical brown and others. We will also put a special emphasis on emerging approaches, both biological and chemical, that can manipulate these cells for therapeutic purposes. It is our hope and belief that this meeting can nucleate expanded efforts in both academia and pharma to explore this promising research area. There has not been a Keystone Symposia conference dedicated to brown fat. While there has been a session here and there at the Obesity meeting, the science and the biomedical needs warrant this new and focused conference. Of course, this will also bridge the Obesity and Diabetes communities, and lead to pharma/academic collaborations.
Year(s) Of Engagement Activity 2015
URL http://www.keystonesymposia.org/15D5
 
Description Vienna, Austria. 15th-19th October 2016. UEG Week. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 2. Vienna, Austria. 15th-19th October 2016. UEG Week. Main meeting on gastroenterology in Europe.
Year(s) Of Engagement Activity 2016
 
Description Vienna, Austria. 2nd February 2018. Seminar at Vienna Biocenter 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Vienna, Austria. 2nd February 2018. Seminar at Vienna Biocenter. Lecture to postcs in this institute and meetings with specific students to discuss their projects
Year(s) Of Engagement Activity 2018
URL https://cluster.meduniwien.ac.at/index.php?id=3732&tx_ttnews%5Btt_news%5D=3280&tx_ttnews%5Bpointer%5...
 
Description World Forum on Scientific & Technological Innovation in London. Looking for solutions to the emerging epidemic of ageing related health problems in China 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Highlights from the World Forum on Scientific & Technological Innovation in London. Looking for solutions to the emerging epidemic of ageing related health problems in China
Year(s) Of Engagement Activity 2018
URL https://www.linkedin.com/in/toni-vidal-puig-md-phd-frcp-fmedsci-emba-43804113/detail/recent-activity...
 
Description Wroclaw, Poland. 3rd - 7th May 2014. European Congress of Endocrinology. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Here you will find all ECE 2014 information, including details of the pre-congress courses and include the oral communications that have been chosen following the abstract selection meeting in the scientific programme.

We look forward to welcoming you to Wroclaw for ECE 2014.

Paolo Beck-Peccoz
Joint Chair, Programme Organising Committee (POC)
Year(s) Of Engagement Activity 2014
URL http://www.ece2014.org/
 
Description Örebro/Sweden. 26th-28th August 2018. Nordic Metabolomics Conference. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Örebro/Sweden. 26th-28th August 2018. Nordic Metabolomics Conference. Role of lipidomics in metabolic research
Opening keynote lecture
Antonio Vidal-Puig (University of Cambridge, UK)
"Adipose tissue expandability, lipotoxicity and the metabolic syndrome"
Year(s) Of Engagement Activity 2018
URL https://www.oru.se/english/about-us/conferences/nordic-metabolomics-conference/program/
 
Description -Conference "Metabolism in Action - Lifetime influence of genes and environment" (1-5th October) by the Copenhagen Bioscience Conferences, a Novo Nordisk Foundation initiative, in Hillerød, Denmark ---- Poster session: S Rodriguez-Cuenca*, S Carobbio*, R Dias , G Barcelo-Cobjlin, X Prieur, J Relat-Pardo, R Amat, M Campbell, M Bahri and A Vidal-Puig. P465L PPARg mutation confers partial resistance to the hypolipidaemic action of fibrates. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact -Conference "Metabolism in Action - Lifetime influence of genes and environment" (1-5th October) by the Copenhagen Bioscience Conferences, a Novo Nordisk Foundation initiative, in Hillerød, Denmark ---- Poster session: S Rodriguez-Cuenca*, S Carobbio*, R Dias , G Barcelo-Cobjlin, X Prieur, J Relat-Pardo, R Amat, M Campbell, M Bahri and A Vidal-Puig. P465L PPARg mutation confers partial resistance to the hypolipidaemic action of fibrates.
Year(s) Of Engagement Activity 2017
 
Description . Cambridge, UK. 11th April 2016. British Heart Foundation Cardiovascular Research Excellence Annual Event. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact 4. Cambridge, UK. 11th April 2016. British Heart Foundation Cardiovascular Research Excellence Annual Event.
Year(s) Of Engagement Activity 2016
 
Description . London, UK. 11th January 2017. Seminar at the MRC Clinical Sciences Centre, Imperial College London. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact . London, UK. 11th January 2017. Seminar at the MRC Clinical Sciences Centre, Imperial College London.
Year(s) Of Engagement Activity 2016
 
Description 1. London, UK. 10th -11th February 2020. 3rd Global nonalcoholic steatohepatitis (NASH) Congress and co-located 1st Metabolic Syndrome, Diabetes and nonalcoholic fatty liver disease (NAFLD) Congress London. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact 1. London, UK. 10th -11th February 2020. 3rd Global nonalcoholic steatohepatitis (NASH) Congress and co-located 1st Metabolic Syndrome, Diabetes and nonalcoholic fatty liver disease (NAFLD) Congress London.

Key meeting to engage with industry.
Year(s) Of Engagement Activity 2020
URL http://www.global-engage.com/event/nash/
 
Description 11/11/2014- www.teinteresa.es, Madrid Brown fat 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact La grasa marrón, clave en la lucha contra la obesidad
1456655859
11/11/2014- www.teinteresa.es, Madrid

Las compañías farmacéuticas están invirtiendo en la investigación para desarrollar un método para convertir la grasa blanca en grasa marrón.
Modificaciones de la flora bacteriana han podido ayudar a reducir la obesidad en animales, y podría aportar soluciones a la obesidad humana
Year(s) Of Engagement Activity 2014
URL http://www.teinteresa.es/salud/grasa-marron-clave-lucha-obesidad_0_1246676023.html
 
Description 15th European Congress of Endocrinology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 15th European Congress of Endocrinology, Copenhagen, Denmark. 27th April - 1st May 2013.

As organiser of the conference we contributed to the impact on 3000 attendees.
Year(s) Of Engagement Activity 2013
URL http://www.ece2013.org/
 
Description 2. Cambridge, United Kingdom. 5th July 2019 Joint work shop by Cambridge University Nanjing Centre of Technology and Innovation, Institute Metabolic Science, University of Cambridge, Model Animals Research Centre (MARC), University of Nanjing. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Cambridge, United Kingdom. 5th July 2019 Joint work shop by Cambridge University Nanjing Centre of Technology and Innovation, Institute Metabolic Science, University of Cambridge, Model Animals Research Centre (MARC), University of Nanjing.

Meeting and networking event with colleagues from Cambridge and Nanjing to develop collaborative network
Year(s) Of Engagement Activity 2019
 
Description 23/01/2017 Invited Talk, Meeting "Bile Acids, Nuclear Receptors and Nutrition" (Metabolic Control of Liver Regeneration and Hepatocellular Carcinogenesis: Nuclear Receptors and Beyond), University Medical Centre Utrecht, NL 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 23/01/2017 Invited Talk, Meeting "Bile Acids, Nuclear Receptors and Nutrition" (Metabolic Control of Liver Regeneration and Hepatocellular Carcinogenesis: Nuclear Receptors and Beyond), University Medical Centre Utrecht, NL
Year(s) Of Engagement Activity 2017
 
Description 28/07/2017 Faculty Speaker, NEEDPRO Summer School in Applied Human Nutrition (Diet and Fatty Liver: A Case Study), Cambridge, UK 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 28/07/2017 Faculty Speaker, NEEDPRO Summer School in Applied Human Nutrition (Diet and Fatty Liver: A Case Study), Cambridge, UK This is an annual summer course on Nutrition
Year(s) Of Engagement Activity 2017
 
Description 29/06/2017 Faculty Speaker, University Rey Juan Carlos (URJC) Summer School for University students and Working Professionals (Molecular basis of NASH development and progression; lipids and beyond). Madrid, ES 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 29/06/2017 Faculty Speaker, University Rey Juan Carlos (URJC) Summer School for University students and Working Professionals (Molecular basis of NASH development and progression; lipids and beyond). Madrid, ES
Year(s) Of Engagement Activity 2017
 
Description 3. Tsukuba, Japan. 17th-19th September 2016. Tsukuba Global Science Week. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Tsukuba, Japan. 17th-19th September 2016. Tsukuba Global Science Week.
Year(s) Of Engagement Activity 2016
 
Description 30th September 14th Annual Cambridge Immunology Forum Meeting Cambridge, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 14th Annual Cambridge Immunology Forum Meeting
Organisers: Marc Veldhoen, Arthur Kaser, Toni Vidal-Puig, Brian Ferguson

Increased knowledge and projection of the lab
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk/upcoming-conferences-organised-by-prof-vidal-puig/
 
Description 4. Bradford, UK. 1st December 2018. SRUK Seminar (Society of Spanish Researchers in the UK). 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact 4. Bradford, UK. 1st December 2018. SRUK Seminar (Society of Spanish Researchers in the UK).
Year(s) Of Engagement Activity 2018
URL https://www.eventbrite.co.uk/e/v-christmas-seminar-science-of-healthy-diet-sports-wellbeing-tickets-...
 
Description 5. Valencia, Spain. 13th-15th November 2019 Spain Minisymposium Centro de Investigación Príncipe Felipe (CIPF). Longevity world forum, "Preclinical Models in Ageing and Metabolism Research" 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact 5. Valencia, Spain. 13th-15th November 2019 Spain Minisymposium Centro de Investigación Príncipe Felipe (CIPF). Longevity world forum, "Preclinical Models in Ageing and Metabolism Research"

Global forum related to Ageing from a socio scientific and multicultural perspective. Open to lay public and highly advertised.
Year(s) Of Engagement Activity 2019
URL https://www.longevityworldforum.com/tag/aging-2/
 
Description 5. London, UK. 30th October 2018. California Walnut Commission Scientific & Health Research Meeting. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 5. London, UK. 30th October 2018. California Walnut Commission Scientific & Health Research Meeting.
Year(s) Of Engagement Activity 2018
URL https://www.bighospitality.co.uk/News/Promotional-Features/California-Walnut-Culinary-Institute-of-A...
 
Description 6. Colorado, USA. 31st March - 5th April 2019. Keystone Symposia on Lipidomics and Functional Metabolic Pathways in Disease. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Colorado, USA. 31st March - 5th April 2019. Keystone Symposia on Lipidomics and Functional Metabolic Pathways in Disease.

Conference at Keystone related to lipidomic analysis in the context of lipotoxicity
Year(s) Of Engagement Activity 2019
URL https://tks.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1595
 
Description 6. Sheffield, UK. 10th-11th September 2018. The British Society for Cardiovascular Research Autumn Meeting 'Inflammation and repair'. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact 6. Sheffield, UK. 10th-11th September 2018. The British Society for Cardiovascular Research Autumn Meeting 'Inflammation and repair'.
Year(s) Of Engagement Activity 2018
URL https://bscr.org/event/bscr-autumn-meeting-2018-inflammation-and-repair/
 
Description ADA 2016. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact New Orleans, USA. 10th - 14th June 2016. American Diabetes Association's Scientific Session's 76th Scientific Sessions.
Year(s) Of Engagement Activity 2016
 
Description Adipose tissue expandaqbility-EL COMERCIO ASTURIAS 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact <>
Antonio Vidal-Puig, catedrático en Cambridge y director adjunto del Centro de Obesidad y Enfermedades Asociadas. Premio Internacional Hipócrates 2015
<>
Year(s) Of Engagement Activity 2015
URL http://www.elcomercio.es/asturias/201511/27/puede-obeso-saludable-siempre-20151127002423-v.html
 
Description Advisory Board Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Health professionals
Results and Impact EASO Scientific Advisory Board Meeting
18th - 19th March 2013, Brussels


redefinitionn of obesity on the baseis of body composition. BMI considered obsolete.
Year(s) Of Engagement Activity 2013
 
Description Amsterdam, Netherlands. 5th-6th November 2019. Maternal obesity and pre-eclampsia 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Amsterdam, Netherlands. 5th-6th November 2019. Maternal obesity and pre-eclampsia. This was a conference organised by Biochemical Society where I gave the closing lecture as part of being awardee of the Sir Philip Randle Lecture, Biochemical Society
Year(s) Of Engagement Activity 2019
URL https://biochemistry.org/grants-and-awards/awards/the-sir-philip-randle-lecture/
 
Description Antalya, Turkey. 23rd-26th October 2014. Endobridge. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact ENDOBRIDGE 2014, 2nd EndoBridge Meeting is one of the extensive event on Pituitary Disease, Thyroid Disorders, Obesity, Endocrinology, Endocrine, Medical, Hormone Research, Hormonal Systems, Ageing, Bone And Osteoporosis, Diabetes, Hormones, Paediatric Endocrinology, Puberty, Steroids and Testosterone segments.
2nd EndoBridge Meeting is organized annually.
Year(s) Of Engagement Activity 2014
URL http://eventegg.com/endobridge-2014/
 
Description Award Lecture in Boston, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Health professionals
Results and Impact 22nd Pat Usher Memorial Award Lecture, Harvard Medical School, Boston, USA. 18th January 2013.

-
Year(s) Of Engagement Activity 2013
 
Description BAT in Granada 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Interested in Brown Adipose Tissue? Can't miss this Symposium! https://finut-en.congressus.es/symposiumbat/index @ibsGRANADA @CIBER_OBN @TVPLab @FIBAO @CanalUGR @finutibero
Year(s) Of Engagement Activity 2018
URL https://twitter.com/ruizruizjonatan/status/1024216467729010688?s=12
 
Description Barcelona, Spain. 24th-25th November 2017. AstraZeneca - Diabetter: The implications of the adipocyte in T2D 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Barcelona, Spain. 24th-25th November 2017. AstraZeneca - Diabetter: The implications of the adipocyte in T2D. Symposia organised by Astra Zeneca addressed to Spanish Endocrinologists
Year(s) Of Engagement Activity 2017
 
Description Barcelona, Spain. 8th October 2016. CIBERDEM-MSD Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Barcelona, Spain. 8th October 2016. CIBERDEM-MSD Symposium
Year(s) Of Engagement Activity 2016
 
Description Basel, Switzerland. 11th-14th September 2018. EMBO at Basel Life. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 2. Basel, Switzerland. 11th-14th September 2018. EMBO at Basel Life.
Year(s) Of Engagement Activity 2018
URL https://www.basellife.org/basel-life-2018.html
 
Description Bilbao, Spain. 8th June 2018. Seminar at Biogune. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 7. Bilbao, Spain. 8th June 2018. Seminar at Biogune.
Year(s) Of Engagement Activity 2018
URL https://twitter.com/CICbioGUNE
 
Description Blog 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog from Sanger wich bord reach where we presented our research on brown fat

From clinical studies and animal models, scientists have noticed that some obese individuals can maintain a remarkable capacity to store fat before experiencing adverse metabolic effects associated with obesity, such as insulin resistance and Type 2 diabetes. It seems that the adipose tissue of these people has developed adaptive mechanisms that allow it to preserve its functionality while adjusting its biochemical features to maintain its biophysical characteristics. Read more here.

Blog by
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk/events
 
Description Blog 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Fighting fat with fat
Obesity is one of the most important biomedical problems in our society and also one of the most frustrating to tackle. For this reason, the recent identification of functional brown fat in adult humans has made the obesity research community very excited. Read more here.

Sanger Institute Blog by Dr Stefania Carobbio

Projection of our lab
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk/events/
 
Description Blog 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog from Sanger wich bord reach where we presented our research on brown fat

From clinical studies and animal models, scientists have noticed that some obese individuals can maintain a remarkable capacity to store fat before experiencing adverse metabolic effects associated with obesity, such as insulin resistance and Type 2 diabetes. It seems that the adipose tissue of these people has developed adaptive mechanisms that allow it to preserve its functionality while adjusting its biochemical features to maintain its biophysical characteristics. Read more here.

Blog by Dr Stefania Carobbio
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk
 
Description Blog 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog from Sanger wich bord reach where we presented our research on brown fat

From clinical studies and animal models, scientists have noticed that some obese individuals can maintain a remarkable capacity to store fat before experiencing adverse metabolic effects associated with obesity, such as insulin resistance and Type 2 diabetes. It seems that the adipose tissue of these people has developed adaptive mechanisms that allow it to preserve its functionality while adjusting its biochemical features to maintain its biophysical characteristics. Read more here.

Blog by
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk
 
Description Blog BAT 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog from Sanger wich bord reach where we presented our research on brown fat

From clinical studies and animal models, scientists have noticed that some obese individuals can maintain a remarkable capacity to store fat before experiencing adverse metabolic effects associated with obesity, such as insulin resistance and Type 2 diabetes. It seems that the adipose tissue of these people has developed adaptive mechanisms that allow it to preserve its functionality while adjusting its biochemical features to maintain its biophysical characteristics. Read more here.

Blog by
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk/events
 
Description Blog BAT 2 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog from Sanger wich bord reach where we presented our research on brown fat

From clinical studies and animal models, scientists have noticed that some obese individuals can maintain a remarkable capacity to store fat before experiencing adverse metabolic effects associated with obesity, such as insulin resistance and Type 2 diabetes. It seems that the adipose tissue of these people has developed adaptive mechanisms that allow it to preserve its functionality while adjusting its biochemical features to maintain its biophysical characteristics. Read more here.

Blog by
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk/events
 
Description CNN interview about LR11 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact New protein could help burn fat faster
By Meera Senthilingam, for CNN
Updated 1109 GMT (1909 HKT) February 1, 2016
(CNN)-Research has shown that the fatter your body becomes, the harder it becomes to burn that excess fat.
As people eat more fat than they burn, the body stores this excess in various parts of the body and as this storage increases, metabolism changes.

However, all is not lost: a recent study by researchers at the University of Cambridge identified one of the proteins underlying this blockage of fat burn. "[This protein] is part of the system in place to help the body store more energy," says Antonio Vidal-Puig, Professor in Molecular Nutrition and Metabolism, who worked on the study.

The culprit, called sLR11, was found to block the functioning of brown fat cells -- responsible for generating heat to keep us warm -- and instead help the body store fat more efficiently by preventing excessive heat generation.


The benefits of brown fat








There are two forms of fat cells -- brown cells and white cells -- and each plays a different role in our metabolism.



While brown cells help generate heat, the white cells are responsible for the storage of fat -- or energy -- ready for release as needed. Levels of brown fat are known to be high in children but recent findings showing the presence of brown fat in adults, restored hope to use them as targets to treat obesity.



According to Vidal-Puig, obese people have less brown fat than lean people -- and the same applies for diabetics. "If you can increase the brown fat in obese and diabetic people then you can improve their situation," says Vidal-Puig. This has been known for some time, but making it a reality has been a challenge.

The newly discovered sLR11 protein could provide the answer.


Removing the brakes


Vidal-Puig compares the protein to the brake of a car, stopping the body from accelerating its production of heat. "Obese people have more of these brakes, preventing them from creating heat and therefore losing fat," says Vidal-Puig who has seen elevated levels of the protein in the blood of obese people included in his study.

During the study, the team removed the gene producing this protein in mice and found they were able to burn calories faster.

The researchers went on to examine the protein in humans and found that levels of the protein correlated with the total fat mass in a person. What's more, investigated levels in obese patients after they underwent bariatric surgery, and their weight loss was directly proportional to the decrease in levels of the sLR11 protein.

"[Brown fat cells] are an attractive therapeutic target for weight loss, and for anti-obesity or anti-type 2 Diabetes (T2D) therapies," says Carole Sztalryd, Associate Professor of Medicine at the University of Maryland School of Medicine. Sztalryd's team also work on biological approaches to weight loss.


More brown than white on the cards


A common focus to tackle obesity has been on accelerating the production of brown fat cells so people burn more calories, but this new insight could achieve the same but through enhancing the activity -- and efficiency -- of cells. "We are stopping the brakes within the fat cells," says Vidal-Puig, as the mice in his study became protected from obesity with increased browning of their white fat cells.

The team believe controlling energy storage will be a better approach to beat the obesity epidemic than controlling people's eating habits.

But Sztalryd warns that additional studies are required to evaluate any clinical relevance,"New therapies are urgently needed for obesity. sLR11 seems promising but more work is needed to confirm if this is a relevant," she says.

In the mean time, old tactics may be the answer and the more weight gained, the more exercise to be done.
Year(s) Of Engagement Activity 2015
URL http://edition.cnn.com/2016/02/01/health/new-protein-fat-burn-feat/
 
Description Cadiz, Spain. 8th-11th April 2019. EMBO "Organ Crosstalk in Energy Balance and Metabolic Disease". 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 10. Cadiz, Spain. 8th-11th April 2019. EMBO "Organ Crosstalk in Energy Balance and Metabolic Disease".

3 day conference organised by EMBO to discuss interorgan communication and its relevance in metabolic disease.
Year(s) Of Engagement Activity 2019
URL https://meetings.embo.org/event/19-organ-crosstalk
 
Description Cambridge Metabolic Network/Danish Diabetes Association Course for PhD Students. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Course sponsored by NOVO foundation from Denmark, 35 PhD students from Cambridge and Denmark.
Year(s) Of Engagement Activity 2017
URL https://www.danishdiabetesacademy.dk/events/lipid-metabolism-new-methods-and-translational-aspects
 
Description Cambridge, UK. 13th April 2015. BHF Centre of Research Annual Symposium. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact http://www.cardiovascular.cam.ac.uk/
The overarching scientific objective of the Centre is to advance understanding of pathobiology, diagnosis, prevention and therapy of selected common and rare cardiovascular conditions by applying our combined expertise in generating assumption-free approaches.
Year(s) Of Engagement Activity 2015
URL http://www.cardiovascular.cam.ac.uk/research/cambridgecre
 
Description Cambridge, United Kingdom. 2nd -4th July 2019 EAS Advanced Course in Cardiometabolic Phenotyping 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Cambridge, United Kingdom. 2nd -4th July 2019 EAS Advanced Course in Cardiometabolic Phenotyping

Training hands on to develop expertise in cardiometabolic phenotyping
Year(s) Of Engagement Activity 2019
URL https://www.eas-society.org/events/EventDetails.aspx?id=1211946
 
Description Chairing the Festival of Ideas event "WHAT'S STOPPING YOUR DIET BEING MORE SUSTAINABLE? 24TH OCT 5:30-6:30PM, DEPT. OF PLANT SCIENCES LECTURE THEATRE. Cambridge 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Chairing the Festival of Ideas event "WHAT'S STOPPING YOUR DIET BEING MORE SUSTAINABLE? 24TH OCT 5:30-6:30PM, DEPT. OF PLANT SCIENCES LECTURE THEATRE. Cambridge
Year(s) Of Engagement Activity 2007,2017
 
Description Cherry Hinton Lions Under 10s Blue Football Club sponsored by IMS/TVP lab 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact This is an action to promote fitness in children as a strategy to prevent orreverse obesity

Children know what is the IMS and that obesity and diabetes can be prevented by exercise.
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk/events/
 
Description Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Edmonton, Canada. 2nd May 2016. Distinguished Speaker Lecture, University of Alberta. !50 approx. students and post docts attended lecture.
Year(s) Of Engagement Activity 2016
 
Description DAILy MAIL ON LR11 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Why the bigger you are, the HARDER it is to lose weight: Stored fat 'fights against the body's attempts to shed the pounds'
Fat cells produce the protein sLR11 which inhibits thermogenesis
This is a process by which fat cells burn calories for energy
The more fat a person has, the more protein will be produced and the less calories burned, preventing weight loss
Experts: Finding could help treat conditions such as obesity and diabetes
By Madlen Davies for MailOnline
Published: 17:04, 24 November 2015 | Updated: 17:57, 24 November 2015
Read more: http://www.dailymail.co.uk/health/article-3331892/Why-bigger-harder-lose-weight-Stored-fat-fights-against-body-s-attempts-shed-pounds.html#ixzz41SHV7aRj
Follow us: @MailOnline on Twitter | DailyMail on Facebook
Year(s) Of Engagement Activity 2015
URL http://www.dailymail.co.uk/health/article-3331892/Why-bigger-harder-lose-weight-Stored-fat-fights-ag...
 
Description Doha, Qatar. 4th-6th December 2019 Anti-Doping Laboratory Qatar for the 7th Junior Symposium 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact This activity was related to a PhD annual conference ree=lated to the course for women in Qatar as part of the programme coordinated by Univeristy College of London, Bristol and Groningen.
Year(s) Of Engagement Activity 2019
 
Description EPOS2019 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Wehosted the 2020 Horizon EPoS project Steering commitee meeting at St Catherine College in Cambridge to discuss the latest results on the pathogenesis, diagnostic and treatment of fatty liver and NASH.
Year(s) Of Engagement Activity 2019
URL https://www.linkedin.com/in/toni-vidal-puig-md-phd-frcp-fmedsci-emba-43804113/detail/recent-activity...
 
Description Engordar La ciencia Asturias 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Engordar la ciencia
El endocrino Antonio Vidal-Puig reivindica el valor económico de la investigación al recibir el premio del Colegio de Médicos
El endocrinólogo Antonio Vidal-Puig, catedrático de la Universidad de Cambridge y uno de los mayores expertos del mundo en obesidad, aprovechó la conferencia con la que recibió ayer en Oviedo el Premio Internacional Hipócrates Central Lechera Asturiana de la Real Academia de Medicina y Cirugía para reclamar un mayor apoyo a la actividad investigadora en España. "Los países que no tienen grandes recursos naturales dependen de la economía del conocimiento, y nosotros podemos ser económicamente más potentes gracias a la ciencia", subrayó Vidal-Puig, que pertenece a 21 comités internacionales de expertos y ha publicado 220 artículos en revistas especializadas
Year(s) Of Engagement Activity 2015
URL http://www.lne.es/asturias/2015/11/27/engordar-ciencia/1847307.html
 
Description Europe press 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact This was an interview for Europe press news agency which has a huge diseminattion capacity. Some examples below.

http://www.europapress.es/chance/noticias.aspx?buscar=Antonio%2BVidal%2BPuig

http://www.europapress.es/chance/elbuenvivir/noticia-10-obesos-son-saludables-20111128124545.html

http://www.europapress.es/chance/noticias.aspx?buscar=Cambridge

http://www.enfermeriapalencia.com/modules.php?name=Noticias_enfermeras

Highewr visibility. Partients have contacted me through email with personal cases that have I have replayed so far but that if they continue to increase i may need to organise better through my web page. I am considering if i get resources to maintain in to include a page in my web for public questions and disemination.
Year(s) Of Engagement Activity 2011
URL http://www.europapress.es/chance/noticias.aspx?buscar=Antonio%2BVidal%2BPuig
 
Description Form the future Careers Carousel at Sawston Village College 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Form the future Careers Carousel at Sawston Village College
Year(s) Of Engagement Activity 2017
 
Description GACETA MEDICA-Lilly 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Gaceta Médica
Domingo, 28 de Febrero de 2016
Felipe Casanueva Freijo, presidente de la Sociedad Española para el Estudio de la Obesidad, y Manuel Puig-Domingo, presidente de la Sociedad Española de Endocrinología y Nutrición, entregaron al profesor Antonio Vidal Puig el "Premio Fundación Lilly a una Carrera Distinguida 2015" en la especialidad de Endocrinología, Nutrición y Obesidad por su contribución al conocimiento del tejido adiposo y el abordaje y prevención de la obesidad. Este galardón fue otorgado en el marco del Simposio Internacional 'Lo último en Obesidad'
Year(s) Of Engagement Activity 2016
URL http://www.gacetamedica.com/noticias-medicina/2015-12-04/en-10-minutos/premio-a-la-trayectoria-en-en...
 
Description Geneva, Switzerland. 23rd January 2018. Symposium: Neuroendocrine regulation of metabolism and dysfunctions in obesity/type 2 diabetes 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Geneva, Switzerland. 23rd January 2018. Symposium: Neuroendocrine regulation of metabolism and dysfunctions in obesity/type 2 diabetes
Year(s) Of Engagement Activity 2018
URL http://www.unige.ch/medecine/diabetescentre/fr/actualites/sym/
 
Description Gothenburg, Sweden. 5th October 2018. Wallenberg Lab 30th Anniversary Symposium. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Gothenburg, Sweden. 5th October 2018. Wallenberg Lab 30th Anniversary Symposium.
Year(s) Of Engagement Activity 2018
 
Description Harrogate, United Kingdom. 6th-8th November 2017. Society for Endocrinology BES Conference. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Harrogate, United Kingdom. 6th-8th November 2017. Society for Endocrinology BES Conference. Lecture related to Medal award.
Year(s) Of Engagement Activity 2017
URL https://www.endocrinology.org/events/sfe-bes-conference/sfe-bes-2017/
 
Description Heidelberg, Germany. 12th May 2016. Seminar at German Cancer Research Center (DKFZ) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Heidelberg, Germany. 12th May 2016. Seminar at German Cancer Research Center (DKFZ)
Year(s) Of Engagement Activity 2016
 
Description Heidelberg, Germany. 16th - 17th October 2015. International Symposium On Diabetic Complications 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Heidelberg, Germany. 16th - 17th October 2015. International Symposium On Diabetic Complications
Event Description

HIDC 2015, 2th Heidelberg International Symposium on Diabetic Complications is going to be placed in between 16 October, 2015 and 17 October, 2015.

The Symposium place is going to be Heidelberg University Hospital.

HIDC 2015 is likely to be a stage where many notable themes are likely to be discoursed. Several of these are going to be Biology, Metabolic Diseases, Diabetes, Diabetes Research, Medical and Health Care.

2th Heidelberg International Symposium on Diabetic Complications is organized annually.
Year(s) Of Engagement Activity 2015
URL https://www.klinikum.uni-heidelberg.de/Welcome.138789.0.html
 
Description International Congress on Obesity 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Vancouver, Canada. 1st - 4th May 2016. 13th International Congress on Obesity. 250 attendes
Year(s) Of Engagement Activity 2016
 
Description International Symposium: Latest in obesity Madrid, Spain. 1st - 2nd December 2015. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact http://www.fundacionareces.es/fundacionareces/cargarAplicacionAgendaEventos.do?idTipoEvento=1&identificador=1827?elAgenda=2
Along with obesity, diabetes is a true pandemic of the 21st century which carries a certain risk of other diseases such as cardiovascular diseases, or even cancer. It is purpose of this symposium to bring to our attention and knowledge the most recent advances on the disease and we hope to do so thanks to the remarkable roster of personalities who have accepted our invitation to share their knowledge and ideas in this INTERNATIONAL SCIENTIFIC SYMPOSIUM: LATEST IN OBESITY sponsored by the Fundación Ramón Areces and with the collaboration of the Fundación General CSIC.
Year(s) Of Engagement Activity 2015
URL http://www.fundacionareces.es/fundacionareces/cargarAplicacionAgendaEventos.do?idTipoEvento=1&identi...
 
Description Japan, 2015. 21st-24th May 2015. 58th Annual Meeting of the Japan Diabetes Society: Evolution and Deepening of Diabetology. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 4. Japan, 2015. 21st-24th May 2015. 58th Annual Meeting of the Japan Diabetes Society: Evolution and Deepening of Diabetology.
Year(s) Of Engagement Activity 2015
URL http://www.jds.or.jp/modules/en/index.php?content_id=45
 
Description Keystone Symposia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keystone Symposia - Nuclear Receptors and Friends: Roles in Energy Homeostasis and Metabolic Dysfunction. Alpbach, Austria, 3rd-8th April 2113.

Keystone Symposia - Systems Biologyof Lipid Metabolism (9th - 13th February 2015)
Colorado, USAOrganisers: Matej Orešic, Antonio Vidal-Puig, Ana Maria Cuervo

Increased applicants to the lab
Year(s) Of Engagement Activity 2013,2014
URL http://www.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1235
 
Description LR11 in Asia 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact LR11 news disseminated in Asia
???LR11/SorLA?????????????????????BMI???????????
Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans
Year(s) Of Engagement Activity 2015
URL https://www.natureasia.com/ja-jp/ncomms/abstracts/71218
 
Description La obesidad está en el cerebro" Lilly Areces 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Más de 500 millones de personas en el mundo padecen obesidad.
Un simposio organizado por la Fundación Ramón Areces y la Fundación General del CSIC analiza las últimas investigaciones sobre este problema de salud pública.
Year(s) Of Engagement Activity 2015
URL http://hipertextual.com/2015/12/obesidad#
 
Description Lisbon, Portugal. 21st-23rd May 2017. Aegerion ECE Symposium. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lisbon, Portugal. 21st-23rd May 2017. Aegerion ECE Symposium. This was a symposia with clear clinical translational implications addressed to practitioners that had implications on their practice.
Year(s) Of Engagement Activity 2017
URL http://www.ece2017.org/media/1123/ece-2017-satellite-programmes_280317.pdf
 
Description London, UK. 11th March 2015. Diabetes UK for the Adipose Plenary Conference. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The Diabetes UK Professional Conference, organized by the Diabetes UK will take place from 11th March to the 13th March 2015 at the Excel London in London, United Kingdom. The conference will cover areas like basic science, clinical science, education, clinical care management, healthcare delivery and psychological care.
Year(s) Of Engagement Activity 2015
URL http://10times.com/diabetes-uk-professional-conference
 
Description MIddle EaSt obesity 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Professors Toni Vidal-Puig MD PhD FRCP FMedSci EMBA and Meis Moukayed have honoured us by writing the fascinating article, People with obesity: Their heroic battle to defeat their genes in a hostile hypercaloric sedentary environment. The professors explain why more than 50 human genes, the environment and lifestyle culture all contribute to why it is not so easy as the doctor telling the patient to lose weight. In addition to looking at the 'why' of obesity,
Year(s) Of Engagement Activity 2018
URL https://www.middleeastmedicalportal.com/product/november-december-2018/
 
Description MUJER HOY Engorda La Calefaccion 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Dos órganos distintos: Grasa blanca y grasa parda

1. La grasa blanca es el órgano donde se acumula el exceso de energía para que el organismo la utilice cuando la necesita. Los problemas ocurren cuando ese tejido adiposo blanco se satura y es incapaz de retener más grasa, con lo que esta empieza a acumularse en otros órganos, como el hígado o el músculo, produciendo diabetes, hígado graso y otros problemas de salud.

2. La grasa parda es un órgano diseñado para producir calor. Está presente en los recién nacidos porque son muy vulnerables frente al frío, y tienen que producir calor para mantener la temperatura corporal adecuada. Lo que se ha observado recientemente es que también la tienen algunos adultos. El equipo del profesor Vidal-Puig y otros están estudiando la posibilidad de desarrollar un fármaco capaz de estimular la producción de grasa parda. "El potencial es grande y la posibilidad de efectos secundarios, escasa", explica el experto.
Year(s) Of Engagement Activity 2013
URL http://www.mujerhoy.com/salud/consulta/engorda-calefaccion-714703022013.html
 
Description Madrid, Spain. 20th-21 November 2019 Scientific meeting of the Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Madrid, Spain. 20th-21 November 2019 Scientific meeting of the Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN)

This meeting brings all teh community of investigators on the field of obesity in Spain. It is an excellent place to identify talent.
Year(s) Of Engagement Activity 2019
URL https://www.ciberobn.es/en
 
Description Madrid, Spain. 22nd November 2018. CIBEROBN Annual Symposium. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Madrid, Spain. 22nd November 2018. CIBEROBN Annual Symposium.
Year(s) Of Engagement Activity 2018
URL https://www.ciberobn.es/en
 
Description Madrid, Spain. 31st May 2019. 6th Symposium on Biomedical Research "Advances & Perspectives in Molecular Endocrinology" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact 9. Madrid, Spain. 31st May 2019. 6th Symposium on Biomedical Research "Advances & Perspectives in Molecular Endocrinology"

This was a high level scientific event organised by CSIC in Madrid attended predominantly by experts in endocrinology
Year(s) Of Engagement Activity 2019
URL https://eventos.uam.es/28633/detail/6th-symposium-on-biomedical-reserch-advances-and-perspectives-in...
 
Description Malaga, Spain. 19th - 21st October 2016. Congress of the Spanish Society of Endocrinology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Malaga, Spain. 19th - 21st October 2016. Congress of the Spanish Society of Endocrinology
Year(s) Of Engagement Activity 2016
 
Description Malaga, Spain. 20th-23rd March 2017. Danish Diabetes Academy Postdoc Winter School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact On March 19-24, 2017, a total of 99 Post Doc fellows, third-year PhD students and prominent national and international speakers attended Danish Diabetes Academy's 3rd Winter School in Malaga with focus on different aspects of prevention and treatment of diabetes as well as career development. Malaga, Spain. 20th-23rd March 2017. Danish Diabetes Academy Postdoc Winter School. .
Year(s) Of Engagement Activity 2017
URL https://www.danishdiabetesacademy.dk/node/1087
 
Description Maranon Lecture Award 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Maranon Lecture Award de la Sociedad Espanola de Endocrinologia y Nutricion. Granada, Spain. 15th-17th May 2013.

-
Year(s) Of Engagement Activity 2013
 
Description Members of the TVP lab recently attended the 1st ICAN conference series in Cardiometabolic Disease in Paris. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact TVP Lab members give presentations and posters at 1st ICAN conference series in Cardiometabolic Disease

Members of the TVP lab recently attended the 1st ICAN conference series in Cardiometabolic Disease in Paris. Vanessa Pellegrinelli was selected to give a presentation, and Camilla Ingvorsen, Guillaume Bidault, and Vivian Peirce were selected to present posters. Vivian Peirce was a joint-winner of Young Investigator poster award.



Projection of our lab
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk/events/
 
Description Mujer Hoy La dieta del Bien estar 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact http://www.mujerhoy.com/salud/dieta-bienestar-760227012014.html

"El mundo de la medicina en general, y en el de la nutrición en particular, esta incorporando progresivamente la noción del "microbioma", no los genes humanos, sino las múltiples especies microbianas que comparten con nosotros nuestro propio organismo", señala el profesor Vidal Puig. "Estas bacterias, que superan en número nada menos que los 100 billones conforman un "superorganismo" que la ciencia apenas ha comenzado a cartografiar, pero cuyo papel a la hora de regular el metabolismo humano se revela cada vez más trascendental", asegura el experto.

Trastornos en ese ecosistema, como la pérdida de diversidad de especies bacterianas y la proliferación de bacterias menos deseables, pueden predisponernos a la obesidad y a una larga lista de trastornos. Quizá sería una buena idea aprender a convivir con ese superorganismo que tanto influye en nuestra salud, con una dieta y un estilo de vida más saludables.
Year(s) Of Engagement Activity 2014
URL http://www.mujerhoy.com/salud/dieta-bienestar-760227012014.html
 
Description Nanjing, China. 19th-25th May 2019. The Sino-UK Cardiovascular disease symposium. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 5. Nanjing, China. 19th-25th May 2019. The Sino-UK Cardiovascular disease symposium. Meeting in Nanjing with faculty from Nanjing Medical School for collaborative research and networking
Year(s) Of Engagement Activity 2019
 
Description Nanjing, China. 8th May 2017. Lecture at Nanjing Biomedical Research Institute. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Nanjing, China. 8th May 2017. Lecture at Nanjing Biomedical Research Institute. Talk at this institute in China in front of > 100 students.
Year(s) Of Engagement Activity 2017
 
Description Oxford, UK. 18th January 2019. Seminar in Department of Physiology, Anatomy & Genetics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact Oxford, UK. 18th January 2019. Seminar in Department of Physiology, Anatomy & Genetics
Date: 18 January 2019, 13:00 (Friday, 1st week, Hilary 2019)
Venue:
Sherrington Building
off Parks Road OX1 3PT
See location on maps.ox

Details: Large Lecture Theatre
Speaker: Professor Antonio Vidal-Puig (University of Cambridge)
Organising department: Department of Physiology, Anatomy and Genetics (DPAG)
Organiser contact email address: ana.domingos@dpag.ox.ac.uk
Host: Dr Ana Domingos (University of Oxford, DPAG)
Part of: DPAG Head of Department Seminar Series
Topics: Inflammation, Diabetes, Adipose tissues, Metabolic syndrome, Obesity
Year(s) Of Engagement Activity 2018
URL https://new.talks.ox.ac.uk/talks/id/f6ae26ed-6a85-4ea6-8236-0be648588540/
 
Description Paris, France. 11th-15th April 2018. EASL International Liver Congress. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation at the Paris, France. 11th-15th April 2018. EASL International Liver Congress focused on the pathogenesis of fatty liver and the effect of Lipotoxicty
Year(s) Of Engagement Activity 2018
URL https://easl.eu/discover/events/detail/2018/the-international-liver-congress-2018
 
Description Royal Swedish Academy of Sciences, Journal of Internal Medicine - Key Symposium "Metabolic complications of obesity" 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Organisation of symposia with 150 attendants, 28 speakers from EU, USA, JAPAN, CHINA. Top symposium supported by the Swedish Academy of Sciences and the Journal of Internal Medicine.
Year(s) Of Engagement Activity 2017
URL http://www.mrl.ims.cam.ac.uk/event/metabolic-complications-obesity/
 
Description SCIENCEALERT ON LR11 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Scientists have figured out how your body fights your attempts to lose weight
Bummer.
DAVID NIELD
11 DEC 2015
For those of you who feel like your gym sessions aren't getting you anywhere near your target weight - scientists think they might have found a reason why. A new study has identified a protein that locks excess fat in our bodies, preventing it from being burned off easily.

And while it sucks to know that our bodies are fighting against our attempts to lose weight, the discovery could help to explain why overweight people find it so difficult to shed the additional pounds.
Year(s) Of Engagement Activity 2015
URL http://www.sciencealert.com/here-s-how-your-body-naturally-fights-your-attempts-to-lose-weight
 
Description San Francisco, USA. 13th-17th June 2014. ADA's 74th Scientific Sessions. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact San Francisco, USA. 13th-17th June 2014. ADA's 74th Scientific Sessions.
International conference in Diabetes
Year(s) Of Engagement Activity 2014
URL http://www.medscape.com/viewarticle/827131
 
Description Science News Study inMice suggests drug to turn fat brown could help fight obesity 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact https://www.sciencedaily.com/releases/2018/11/181126123416.htm
Study in mice suggests drug to turn fat 'brown' could help fight obesity
Date:November 26, 2018 Source:University of Cambridge Summary:Our bodies contain two types of fat: white fat and brown fat. While white fat stores calories, brown fat burns energy and could help us lose weight. Now, scientists have found a way of making the white fat 'browner' and increasing the efficiency of brown fat. While their study was carried out in mice, they hope that this finding will translate into humans and provide a potential new drug to help fight obesity.
Year(s) Of Engagement Activity 2018
URL https://www.sciencedaily.com/releases/2018/11/181126123416.htm
 
Description Singapore2019 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact University of Cambridge meets with our colleagues from the National University of Singapore to strenght our collaborative cardiovascular research network.
Year(s) Of Engagement Activity 2019
 
Description Sofia, Bulgaria. 28th - 31st May 2014. European Congress on Obesity. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Sofia, Bulgaria. 28th - 31st May 2014. European Congress on Obesity.
The congress featured the latest research on obesity from a wide range of fields including:

Discovery and Integrative Science
Nutrition, Behaviour, Activity and Environment
Childhood and Lifelong Perspectives
Prevention, Public Health and Epidemiology
Clinical Management and Translation
Obesity as a Gateway to other Diseases
Experts from around the world will present abstracts and deliver symposia on these themes. There will be a series of press conferences to showcase the items most of interest to the media, and press releases issued throughout the congress. A staffed media centre will be available on site to help journalists with their queries and interview requests
Year(s) Of Engagement Activity 2014
URL http://easo.org/european-congress-on-obesity-2014-eco-2014/
 
Description Stockholm, Sweden. 28th June - 2nd July 2014. International Society for the Study of Fatty Acids and Lipids. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact http://www.issfal.org/conferences/2014-stockholm
Stockholm, Sweden. 28th June - 2nd July 2014. International Society for the Study of Fatty Acids and Lipids.
International conference focused on the role of fatty acids in disease
Year(s) Of Engagement Activity 2014
URL http://www.issfal.org/conferences/2014-stockholm
 
Description Suzhou, China. 1st - 5th June 2015. Cold Spring Harbor Asia (CSHA) Conference on Lipid Metabolism and Metabolic Disorders 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The conference will include eight oral sessions and one poster session covering the latest findings across many topics in lipid metabolic. Many talks will be selected from the openly submitted abstracts on the basis of scientific merit and relevance. Social events throughout the conference provide ample opportunity for informal interactions.

Alterations in lipid homeostasis play critical roles in the development of human metabolic disorders, such as obesity, type II diabetes and fatty liver. This meeting brings together world-leading experts to present and discuss latest developments in the study of lipid metabolism, as well as their implications for human health and disease. The conference will include eight oral sessions and one poster session. Additional oral presentations will be selected from the openly submitted abstracts on the basis of scientific merit and relevance. Social events throughout the conference will provide ample opportunities for scientific as well as informal interactions
Year(s) Of Engagement Activity 2015
URL https://www.csh-asia.org/2015meetings/Metabo.html
 
Description TECHTIMES 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Being Fat Makes It Harder To Lose Weight: Fatter People Produce More Protein That Inhibits Depletion Of Fat Cells
Fat people have a more difficult time of losing weight because of the increased production of a protein called sLR11. This inhibits the body's ability to burn calories and fats for heat production
Year(s) Of Engagement Activity 2015
URL http://www.techtimes.com/articles/110892/20151127/being-fat-makes-it-harder-to-lose-weight-fatter-pe...
 
Description Toulouse, France. 28th April 2017. Seminar at INSERM. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Toulouse, France. 28th April 2017. Seminar at INSERM. Dissemination of research outcomes to research commnity
Year(s) Of Engagement Activity 2017
URL https://www.stromalab.fr/actualites/pr-toni-vidal-puig-university-of-cambridge-uk/
 
Description Turku, Finland. 28th January 2016. Frontiers of Science Seminar Series at Biocity Turku 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact http://www.biocity.turku.fi/index.php?id=858
Thursday, January 28
Prof. Antonio Vidal-Puig, University of Cambridge, MRC Institute of Metabolic Science, Cambridge, UK
"Adipose tissue expandability, lipotoxicity and the metabolic syndrome"
Host: Matej Oresic (mtjo(at)steno.dk)
Year(s) Of Engagement Activity 2016
URL http://www.biocity.turku.fi/index.php?id=858
 
Description Tye 2 Diabetes; Atherapeutic avenue is emerging 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Date:December 5, 2018 Source:INSERM (Institut national de la santé et de la recherche médicale) Summary:Restoring the action of insulin is one of the keys to fighting type 2 diabetes. Researchers are developing a therapeutic strategy that uses the properties of an enzyme (hormone-sensitive lipase) which, when stimulating fatty-acid synthesis in the fat cells, has a beneficial effect on insulin action.
Year(s) Of Engagement Activity 2018
URL https://www.sciencedaily.com/releases/2018/12/181205134014.htm
 
Description URJC Summer University Programme: Obesity, Insulin Resistance, and Metabolic Syndrome. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact 5. Madrid, Spain. 9th-11th July 2015. URJC Summer University Programme: Obesity, Insulin Resistance, and Metabolic Syndrome.


Obesity, insulin resistance, diabetes and metabolic syndrome (Código UV-S-OBESI)

La inscripción ha finalizado.





Apúntate





Del 09-07-2015 al 11-07-2015

Salón de Grados, Campus de Madrid, Facultad de Ciencias Jurídicas y Sociales, Paseo de los Artilleros s/n


Organizado por Vicerrectorado de Extensión Universitaria

Teléfono de contacto: 914884762
Categorías:
Formación y docencia sanitaria

Investigación médica

Medicina general
Palabras clave:
Diabetes and metabolic syndrom...

Insulin resistance

Obesity
Year(s) Of Engagement Activity 2015
URL http://uverano.urjc.es/event_detail/2355/programme/obesity-insulin-resistance-diabetes-and-metabolic...
 
Description Valencia, Spain. 17th - 18th October 2019. Liver Investigation: Testing Marker Utility in Steatohepatitis (litmus) 3rd General Assembly. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Valencia, Spain. 17th - 18th October 2019. Liver Investigation: Testing Marker Utility in Steatohepatitis (litmus) 3rd General Assembly.

This was the annual meeting of the IMI Litmus where we are aiming to identify biomarkers of NASH. My group leads the preclinical programme and presented advances in cross species validation of biomarkers
Year(s) Of Engagement Activity 2019
URL https://litmus-project.eu/
 
Description Vancouver, Canada. 12th - 17th January 2014. Keystone Symposium on Obesity: A Multisystems Perspective. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Obesity: A Multisystems Perspective (J2)


Organizer(s) Roger D. Cone, Barbara Cannon and Lee M. Kaplan

January 12-17, 2014

Fairmont Hotel Vancouver • Vancouver, British Columbia Canada

Discounted Abstract Deadline: Oct 4, 2013

Abstract Deadline: Oct 29, 2013

Scholarship Deadline: Oct 4, 2013

Discounted Registration Deadline: Nov 14, 2013


Supported by the Directors' Fund


Joint Meeting: Challenges and Opportunities in Diabetes Research and Treatment (J1)


Summary of Meeting:
This meeting will cover the latest discoveries on the role of multiple organ systems in the process of energy homeostasis and obesity. In addition to the role of the central nervous system and white adipose tissue (WAT) depots, this meeting will examine the role of WAT development, brown fat, the microbiome, gut-brain signaling and circadian rhythms in the development of obesity. Bariatric surgery and the latest pharmaceutical approaches to obesity treatment will also be considered, as will the latest genetic approaches to both common and rare syndromic obesity. Joint sessions with the Keystone Symposia meeting on Challenges and Opportunities in Diabetes Research and Treatment will include "The Role of Brown Adipose Tissue in Thermogenesis and Glucose Uptake" and "Mechanisms Underlying the Efficacy of Bariatric Surgery." This meeting will bring together a diverse array of leading scientists from the U.S., Europe and Japan to talk about breaking discoveries in a very broad array of physiological processes relevant to obesity and its treatment. The goal of the meeting will be to provide participants with an update on cutting-edge developments in the field, as well as with a broader perspective on the biology of obesity. The anticipated outcome is the development of new, and potentially interdisciplinary, research collaborations and directions.
Year(s) Of Engagement Activity 2014
URL http://www.keystonesymposia.org/14J2
 
Description https://en.wikipedia.org/wiki/Antonio_Vidal-Puig 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact https://en.wikipedia.org/wiki/Antonio_Vidal-Puig
Year(s) Of Engagement Activity 2020
URL https://en.wikipedia.org/wiki/Antonio_Vidal-Puig
 
Description https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283
November 27, 2018
Could this be a solution for the obesity crisis?
Samuel Virtue, University of Cambridge; Antonio Vidal-Puig, University of Cambridge, and Vanessa Pellegrinelli, University of Cambridge
Scientists manage to boost brown fat in mice with a molecule called BMP8b. Could this be the future for treating obesity?
Year(s) Of Engagement Activity 2018
URL https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283
 
Description newsweek thermogenesis 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact http://www.newsweek.com/2015/01/30/prepare-pill-make-you-thin-301250.html

In another area of Vidal-Puig's studies lies, potentially, an amazingly simple fix. In spite of all the millions spent on diets, food and exercise, it may be that something as basic as temperature is the answer. We all have two types of fat, white and brown. White fat is inert and sits in deposits. Brown fat, which regulates babies' temperatures but is much harder to pinpoint in adults, can be activated to burn calories and generate heat.

Studies show that exposure to low temperatures may encourage white fat to behave like brown fat. So while central heating ensures we move less and burn fewer calories, it's possible that lower temperatures might increase the activity of brown fat, which will burn our calories for us.
Year(s) Of Engagement Activity 2015
URL http://www.newsweek.com/2015/01/30/prepare-pill-make-you-thin-301250.html