Enhancing the MRC National Survey of Health and Development as an interdisciplinary life course study of ageing
Lead Research Organisation:
University College London
Abstract
The greatest challenge for research on ageing is to ensure that the health and independence of older people keeps apace with their increasing life expectancy. Ageing starts at the beginning of life, and is affected by biological and social processes acting across the whole of life. This programme is concerned with scientific discovery of these processes. We conduct research on the MRC National Survey of Health and Development (NSHD), the oldest of the British birth cohorts. It is unique in having information, from birth to 66 years, on the health and social circumstances of a large representative sample of those born in England, Wales and Scotland in March 1946.
The focus of this programme is on enhancing the NSHD as a national resource by:
Collecting new data on ageing outcomes (www.nshd.mrc.ac.uk)
Undertaking collaborative research to study the factors at different life stages that promote or inhibit healthy ageing (see www.halcyon.ac.uk)
Encouraging the safe and secure use of NSHD resources, including the genetics resource, by the scientific community
The focus of this programme is on enhancing the NSHD as a national resource by:
Collecting new data on ageing outcomes (www.nshd.mrc.ac.uk)
Undertaking collaborative research to study the factors at different life stages that promote or inhibit healthy ageing (see www.halcyon.ac.uk)
Encouraging the safe and secure use of NSHD resources, including the genetics resource, by the scientific community
Technical Summary
The MRC National Survey of Health and Development (NSHD) is the oldest of the British birth cohorts, and is unique in having data from birth to age 66 years on the health and social circumstances of a representative sample (N=5,362) of those born in England, Wales and Scotland in March 1946 (www.nshd.mrc.ac.uk). Enhancing NSHD is the core programme of the MRC Unit for Lifelong Health and Ageing, and combines a research and a resource function.
The resource function is to curate, enrich and share the NSHD resource, on which all Unit programmes and research collaborations depend. In the last five years, we have completed the 23rd follow-up, a pioneering clinic data collection, with a high response rate, developed data sharing policies and web-based data sharing tools, raised the international and national profile of the study through the NSHD 65th birthday events, and enhanced NSHD through new biomarker and genetic data. A critical mass of biomedical and social scientists undertakes collaborative projects; since 2007, NSHD data has been shared with 211 scientists from 49 research institutions.
The research function is to foster integrative research across the Unit programmes and with external collaborators, and to build capacity in life course epidemiology and ageing research. Ongoing studies include: the lifetime determinants of kidney function, thyroid function, and healthy ageing; the long-term health effects of exposure to air pollution; dietary studies; and genetic studies. Much of this work involves comparative research across cohorts. For example, LHA leads the Healthy Ageing across the Life Course (HALCyon) research programme which brings an interdisciplinary group of researchers to study life course determinants of three aspects of healthy ageing across nine UK cohort studies: physical and cognitive capability, social and psychological wellbeing and underlying biology, including aspects of physiology and genetics. More details can be found on www.halcyon.ac.uk.
The two main research themes for NSHD in the next five years are: (1) healthy ageing and the management of health and health care needs as the cohort grows older, and how these are influenced by earlier life experiences; and (2) the biology of ageing, linking epidemiology and mechanistic science in this cohort study. The latter includes planned metabolomic and epigenomic projects, and a new research collaboration on the ageing lung.
We also plan to extend HALCyon cross cohort research activities, data harmonisation and data sharing through our role in the new ESRC/MRC Cohort Resource Facility and through international collaborations.
The resource function is to curate, enrich and share the NSHD resource, on which all Unit programmes and research collaborations depend. In the last five years, we have completed the 23rd follow-up, a pioneering clinic data collection, with a high response rate, developed data sharing policies and web-based data sharing tools, raised the international and national profile of the study through the NSHD 65th birthday events, and enhanced NSHD through new biomarker and genetic data. A critical mass of biomedical and social scientists undertakes collaborative projects; since 2007, NSHD data has been shared with 211 scientists from 49 research institutions.
The research function is to foster integrative research across the Unit programmes and with external collaborators, and to build capacity in life course epidemiology and ageing research. Ongoing studies include: the lifetime determinants of kidney function, thyroid function, and healthy ageing; the long-term health effects of exposure to air pollution; dietary studies; and genetic studies. Much of this work involves comparative research across cohorts. For example, LHA leads the Healthy Ageing across the Life Course (HALCyon) research programme which brings an interdisciplinary group of researchers to study life course determinants of three aspects of healthy ageing across nine UK cohort studies: physical and cognitive capability, social and psychological wellbeing and underlying biology, including aspects of physiology and genetics. More details can be found on www.halcyon.ac.uk.
The two main research themes for NSHD in the next five years are: (1) healthy ageing and the management of health and health care needs as the cohort grows older, and how these are influenced by earlier life experiences; and (2) the biology of ageing, linking epidemiology and mechanistic science in this cohort study. The latter includes planned metabolomic and epigenomic projects, and a new research collaboration on the ageing lung.
We also plan to extend HALCyon cross cohort research activities, data harmonisation and data sharing through our role in the new ESRC/MRC Cohort Resource Facility and through international collaborations.
Organisations
- University College London, United Kingdom (Collaboration, Lead Research Organisation)
- University of Southampton, United Kingdom (Collaboration)
- Universite Montpellier (Collaboration)
- UK Biobank, United Kingdom (Collaboration)
- University of Edinburgh, United Kingdom (Collaboration)
- University of Bristol, United Kingdom (Collaboration)
- Imperial College London, United Kingdom (Collaboration)
- London Sch of Hygiene and Trop Medicine, United Kingdom (Collaboration)
- Newcastle University, United Kingdom (Collaboration)
- Medical Research Council (Collaboration)
- University of Birmingham, United Kingdom (Collaboration)
- National Institutes of Health, United States (Collaboration)
- University of Cambridge (Collaboration)
- Bradford Institute for Health Research (Collaboration)
- Millennium Cohort Study (MCS) (Collaboration)
- University of Manchester, Manchester, United Kingdom (Collaboration)
- King's College London, United Kingdom (Collaboration)
Publications
Adam M
(2015)
Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis.
in The European respiratory journal
AGS/NIA Delirium Conference Writing Group, Planning Committee And Faculty
(2015)
The American Geriatrics Society/National Institute on Aging Bedside-to-Bench Conference: Research Agenda on Delirium in Older Adults.
in Journal of the American Geriatrics Society
Al Saikhan L
(2019)
Left atrial function in heart failure with mid-range ejection fraction differs from that of heart failure with preserved ejection fraction: a 2D speckle-tracking echocardiographic study.
in European heart journal. Cardiovascular Imaging
Albanese E
(2014)
Weight loss and premature death: the 1946 British birth cohort study.
in PloS one
Alfred T
(2014)
Associations between APOE and low-density lipoprotein cholesterol genotypes and cognitive and physical capability: the HALCyon programme.
in Age (Dordrecht, Netherlands)
Allinson JP
(2016)
The Presence of Chronic Mucus Hypersecretion across Adult Life in Relation to Chronic Obstructive Pulmonary Disease Development.
in American journal of respiratory and critical care medicine
Allinson JP
(2017)
Combined Impact of Smoking and Early-Life Exposures on Adult Lung Function Trajectories.
in American journal of respiratory and critical care medicine
Anderson EL
(2017)
Prospective associations of psychosocial adversity in childhood with risk factors for cardiovascular disease in adulthood: the MRC National Survey of Health and Development.
in International journal for equity in health
Anderson EL
(2018)
Associations of adversity in childhood and risk factors for cardiovascular disease in mid-adulthood.
in Child abuse & neglect
| Title | Board to explain Vascular Ageing to the General Public |
| Description | This comic board was designed by Chloe Park and the VascAgeNet Public Engagement Team to explain the concepts of vascular ageing to the general public. |
| Type Of Art | Artwork |
| Year Produced | 2022 |
| Impact | This board is being used to educate the public on Vascular Ageing |
| URL | https://vascagenet.eu/public-engagement |
| Title | Educational Posters- Vascular Ageing |
| Description | Chloe Park and the VascAgeNet public engagement Team developed posters to explain the concepts of Vascular Ageing to clincians and the general public. These posters have been translated into >20 languages. |
| Type Of Art | Artwork |
| Year Produced | 2022 |
| Impact | These posters will help to educate both clinicians and the general public. |
| URL | https://vascagenet.eu/public-engagement |
| Title | Vascular Ageing Illustration |
| Description | An illustration of Vascular Ageing, created by Chloe Park and the VascAgeNet Public Engagement Team |
| Type Of Art | Artwork |
| Year Produced | 2021 |
| Impact | This illustration explains the concepts of vascular ageing to the general public. |
| URL | https://vascagenet.eu/public-engagement |
| Description | All-Party Parliamentary Group on Medical Research |
| Geographic Reach | National |
| Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
| Impact | Study member participated in round table. There were professional speakers who will talk about how patient data is used in research, but the panel also wanted to hear from participants. |
| Description | All-Party Parliamentary Group on Medical Research (APPG) event on big data |
| Geographic Reach | National |
| Policy Influence Type | Participation in a national consultation |
| Description | CLOSER KEW - Particpant engagement |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | MR gave a talk at the CLOSER knowledge exchange workshop on cohort management. The talk sparked discussion and questions afterwards and the Unit led a round table on cohort management of older people. |
| Description | CLOSER Workshop - Cross-cohort research: Opportunities, challenges and examples |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Increased researcher awareness and understanding of the challenges and opportunities related to cross cohort research |
| Description | CLOSER Workshops |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Increased awareness and understanding of researchers in the following areas Functioning well in later life: What is the evidence from longitudinal studies?* ** Symposium January 15th 2013 Knowledge Exchange Workshop: Challenges for Data Harmony* ** KEW January 16th 2013 Knowledge Exchange Workshop: Integrating the social and biological* KEW April 12th 2013 Training workshop: Life Course Research* ** Training workshop Monday 17 March 2014 Successful cohort leadership and management* ** Training workshop Friday 16 May 2014 |
| Description | CLOSER workshop talk in May 2017 - "Adopting new technologies in the MRC National Survey of Health and Development". |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | improved knowledge of researchers |
| Description | China-UK Life Science and Medicine Summit |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Diana Kuh became Vice-Chair on SAPEA International Workin gGroup "Transformin gthe Future of Ageing" in support of European Commission's Scientific Advice Mechanism |
| Geographic Reach | Europe |
| Policy Influence Type | Participation in a advisory committee |
| Description | Diana Kuh became a member of the Scientific Advisory Board, German National Cohort (GNC, NAKO) |
| Geographic Reach | Europe |
| Policy Influence Type | Participation in a advisory committee |
| Description | Diana Kuh is a member of the Springboard Review Working Group for the Academy of Medical Sciences |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Description | Diana Kuh was Principal member of the Scientific Committee. Wellcome Trust Scientific Meeting. Longitudinal studies: Hinxton, Cambridge, May 20th-June 1st 2018 |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Description | Diana Kuh was a Review panel member. Leiden University Medical Centre. |
| Geographic Reach | Europe |
| Policy Influence Type | Participation in a advisory committee |
| Description | GM LHA workshop on Mplus |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Increased knowledge and skills of attendees inthe field of longitudinal data analysis using the mplus software |
| Description | GM Pre conference workshop at Nordic Congress 2014 |
| Geographic Reach | Asia |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Increased knowledge and skills of attendees in the areas of 'mixture models in the context of replication' and 'change point models in ageing research' |
| Description | GM Survival Models Workshop in Uruguay |
| Geographic Reach | South America |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Increased knowledge and skills of attendees in the area of Joint survival models |
| Description | GM Vancouver workshop |
| Geographic Reach | North America |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Pre conference workshop in Vancouver on April 24-26/2014 on Longitudinal Data Analysis using Mplus. The conference is the International Health data Linkage. Increased knowledge and skills of attendees in this area |
| Description | GM workshop in SRCD San Diego |
| Geographic Reach | North America |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Graciela's workshop in SRCD (San Diego) attended by researchers conducting research in Child development. Increased skills and awareness of attendees in the area of 'Recommended Approaches for Coordinated Analysis and Reproducible Multiple-Study Research' |
| Description | Longitudinal data analysis course at UCL |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Increased awareness and skills of attendees in longitudinal data analysis course. Run at UCL ( jointly with Jenny head, Mai Stafford, Owen Nicholas and Amanda Sacker) |
| Description | MRC Unit for Lifelong Health and Ageing Response to PHE request for Strategy Consultation. |
| Geographic Reach | National |
| Policy Influence Type | Participation in a national consultation |
| Description | NICE Menopause Guidelines |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guidance committee |
| Description | Parliamentary Post Note: The Ageing Process and Health |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| URL | http://researchbriefings.parliament.uk/ResearchBriefing/Summary/POST-PN-0571 |
| Description | Progress report written for 2016 BMA Growing up in the UK report on Life course and developmental origins of adult health and disease |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Round table event was organised to discuss the review |
| URL | https://www.bma.org.uk/collective-voice/policy-and-research/public-and-population-health/child-healt... |
| Description | RH expert advisor |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Impact | The guideline aims to improve the consistency of support and information provided to women in menopause. |
| URL | https://www.nice.org.uk/guidance/ng23 |
| Description | Ran Multilevel modelling course at UCL |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Too early to say but researchers should be more skilled in multilevel modelling which should help to improve the quality of research being carried out. |
| Description | Response to Government consultation: National Data Guardian for Health and Care's Review of Data Security, Consent and Opt-Outs |
| Geographic Reach | National |
| Policy Influence Type | Participation in a national consultation |
| Description | Sucessful cohort leadership and management course |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Our director co-organised a training event about successful cohort leadership and management. We hope this event will lead to more researchers taking an interest in leading a cohort and understanding what it means to manage a cohort on a day to day basis. We hope it will lead to the cohort leaders of the future. |
| Description | Talk by AW at CLOSER workshop Working with biological sampes in cohort studies |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Talk by PC at Closer workshop: Methods of disclosure control : Best practive within longitudinal studies |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Written submission to the House of Commons Health Committee inquiry on the impact of physical activity and diet on health. |
| Geographic Reach | National |
| Policy Influence Type | Participation in a national consultation |
| Description | Alzheimers Society Clinical Fellows/UCLH Funding |
| Amount | £150,000 (GBP) |
| Organisation | University College London Hospitals NHS Foundation Trust |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 08/2018 |
| End | 09/2021 |
| Description | Alzheimers Society Clinical Fellows/UCLH Funding |
| Amount | £150,000 (GBP) |
| Organisation | Alzheimer's Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2018 |
| End | 09/2021 |
| Description | Biomedical follow-up of 1958 Birth Cohort Study members at age 60 |
| Amount | £1,544,004 (GBP) |
| Funding ID | MR/P023444/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2017 |
| End | 03/2022 |
| Description | DELPHIC |
| Amount | £980,884 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2016 |
| End | 04/2020 |
| Description | Enhancing Delirium Recovery |
| Amount | £300,000 (GBP) |
| Funding ID | 374 |
| Organisation | Alzheimer's Society Doctoral Training Centre Grant |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Lost and Found Public engagement funding |
| Amount | £123,300 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2018 |
| Description | MRC Proximity to Discovery |
| Amount | £6,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2017 |
| End | 07/2017 |
| Description | Probing Resilience: Predicting critical transitions in the health of older people |
| Amount | £74,729 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | RB Spanish Ministry of Economy and Competitiveness |
| Amount | € 27,000 (EUR) |
| Organisation | Spanish Ministry of Economy and Competitiveness |
| Sector | Public |
| Country | Spain |
| Start | |
| Description | Reta Lila Trust Project Grant |
| Amount | £1,191,595 (GBP) |
| Organisation | Reta Lila Weston Trust For Medical Research |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Springboard Fellowship |
| Amount | £55,000 (GBP) |
| Organisation | University College London |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2016 |
| End | 09/2018 |
| Description | Telefonica - Is it feasible to use mobile data to understand human behavior? |
| Amount | £6,000 (GBP) |
| Organisation | O2 Telefonica Europe plc |
| Sector | Private |
| Country | United Kingdom |
| Start | 05/2017 |
| End | 07/2017 |
| Description | UCL Global Engagement Fund DD |
| Amount | £1,800 (GBP) |
| Organisation | University College London |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 06/2017 |
| Description | Wellcome Trust ISSF |
| Amount | £75,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Title | 60-64 Medication information |
| Description | Medication information from study members collected during 2006-2010 includes |
| Type Of Material | Database/Collection of data |
| Year Produced | 2013 |
| Provided To Others? | Yes |
| Impact | too early to tell - hopefully increased used of the data from NSHD which will lead to impacts |
| Title | Age 68-69 postal questionnaire and home visit |
| Description | A new postal questionnaire was sent to NSHD study members. A variety of questions were asked about Family, home and retirement Wellbeing Lifestyle/social activities Sleep Illnesses and health problems Recent health checks hospital admissions All willing study members had a home visit during 2015-2016. Various things were measured/taken/completed Blood samples Physical activity Anthropometry Cognition Lung capacity Health behaviours Socioeconomic circumstances Medical review |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | too early to say data has only just been cleaned |
| Title | Epigenetic dataset |
| Description | As part of the ESRC-funded epigenetics grant we have generated a large-scale epigenetic datasets from the NSHD (1946 birth cohort). 240 samples have been used on the EPIC array to generate epigenetics data and an additional ~1800 additional samples used on the EPIC array. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | Data is currently being finalised and cleaned for public use. |
| Title | HALCyon data sets and meta data |
| Description | One of the main aims of HALCyon was to perform comparable analyses across 9 British cohort studies which tested the inter-relationships between: physical and cognitive capability; social and psychological wellbeing and; underlying biological markers of ageing. Another main aim was to test the associations of factors across life with each of these three sets of measures. In the majority of cases, this involved harmonising secondary data from the 9 participating studies which had been provided to the HALCyon study team by cohort PIs. For details of how to access the most up to date versions of these secondary data please contact the MRC Unit for Lifelong Health and Ageing at UCL, the relevant cohort leads or where available download these data from UK Data Service ReShare (for ELSA and 1958 birth cohort). The following documentation is freely available via UK Data Service ReShare or the HALCyon data documentation page (1) lists of the comparable variables available in each cohort for topics of relevance to HALCyon; (2) Stata syntax which was used to clean and recode data for use in analyses that were comparable across cohorts. The NDA grant for HALCyon also included funds to - collect comparable data on wellbeing in: Hertfordshire Cohort Study (HCS); Caerphilly Prospective Study (CaPS); Aberdeen Birth Cohort 1936 (ABC1936) See for example: Cooper R et al. AGE 2014;36:445-456 - measure telomere length using existing blood samples in: Lothian Birth Cohort 1921 (LBC1921); CaPS; Hertfordshire Ageing study (HAS); MRC National Survey of Health and Development See for example: Gardner M et al. PLoS One 2013;8(7):e69526 - perform cortisol assays using existing saliva samples in: CaPS and NSHD See for example: Gardner M et al. Psychoneuroendocrinology 2013;38:40-49 - undertake qualitative interviews with HCS and NSHD participants (30 in each study) See for example: The content of the interview topic guide, the sampling strategy and the characteristics of the sample achieved are described in a Centre for Longitudinal Studies working paper (2011/5), by Jane Elliott et al, October 2011 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2014 |
| Provided To Others? | Yes |
| Impact | A data request was made for the HALCyon dataset and this was provided |
| URL | http://www.halcyon.ac.uk/?q=node/366 |
| Title | Lipodomics and Homocysteine 60-64 |
| Description | Lipodomics and Homocysteine collected at age 60-64. A DOI will be created and the data made available to other researchers |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | paper submitted by HNR |
| Description | Advancing understanding of delirium severity: the contribution of domains of the delirium syndrome to outcomes |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration on research project, grant applications, data analysis, manuscript preparation |
| Collaborator Contribution | Collaboration on research project, grant applications, data analysis, manuscript preparation |
| Impact | NIA-NIDUS award $49,872 |
| Start Year | 2017 |
| Description | Biomarkers of Ageing |
| Organisation | Newcastle University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have shared NSHD DNA data and LHA scientists are leading and contributing to scientific outputs |
| Collaborator Contribution | LHA scientists are gaining knowledge about telomeres and other markers of biological ageing |
| Impact | Enriching the NSHD with new data on telomeres. Scientific outputs are forthcoming I have extended the collaboration between LHA and the Institute of Ageing by asking Professor Thomas Zyglinicki to be a work package leader on a telomere study across a number of cohorts as part of the HALCyon research programme on which I am the PI. Baylis et al PMID:24858709 Martin-Ruiz et al PMID: 25239152 PMID 26403813 PMID 26403811 PMID 25239152 |
| Start Year | 2007 |
| Description | CLOSER |
| Organisation | University College London |
| Department | Institute of Education (IOE) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Leading on work packages and the teaching aspect of CLOSER. This includes data analysis, preparing and commenting on manuscripts, organising workshops, seminars and conferences. Members of the executive group and CLOSER communications network. |
| Collaborator Contribution | CLOSER (Cohort & Longitudinal Studies Enhancement Resources) aims to maximise their use, value and impact both at home and abroad. Bringing together eight leading studies, the British Library and the UK Data Service, CLOSER works to stimulate interdisciplinary research, develop shared resources, provide training, and share expertise. In this way CLOSER is helping to build the body of knowledge on how life in the UK is changing - both across generations and in comparison to the rest of the world. |
| Impact | Johnson 2017 PMID:28072856 Bann 2017 PMID: 28072856 2 successful bids to the innovation fund 2 successful bids to the innovation fund Bann, D, Johnson, W, Li, L, Kuh, D, Hardy, R. Socioeconomic inequalities in body mass index, weight, and height in childhood and adolescence: coordinated analyses of individual participant data from four British birth cohort studies initiated in 1946, 1958, 1970, and 2000/1. Lancet Public Health 2018 Apr;3(4):e194-e203. doi: 10.1016/S2468-2667(18)30045-8. Epub 2018 Mar 21. |
| Start Year | 2012 |
| Description | CLOSER innovation Bid - Andy Boyd |
| Organisation | Bradford Institute for Health Research (BIHR) |
| Department | Born in Bradford |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | • establishing an expert working group, comprising studies who have extracted EPRs and those with active plans to do so; • developing, with industry partners, a standard specification for data extracts which is optimised for efficiency, transparency and ability to deliver comparable results; • identifying critical data quality and interoperability issues; and devising recommendations as to how to deal with these; • working with key industry and research infrastructure partners to gain insights, to develop networks and to advocate for longitudinal studies use of EPRs; • considering approaches for harmonising EPR information to support cross-cohort comparison studies; • identifying training/capacity needs and gaps in provision; • working with key industry and health sector partners to consider the impact on longitudinal studies of planned and future changes in health care informatics (e.g. patient access to their own health care EPRs); • writing a position paper summarising our findings and hosting a knowledge exchange workshop to disseminate our findings. This application seeks support for a series of workshops and resource to write the position paper. The programme focuses on data science issues rather than governance issues. |
| Collaborator Contribution | • establishing an expert working group, comprising studies who have extracted EPRs and those with active plans to do so; • developing, with industry partners, a standard specification for data extracts which is optimised for efficiency, transparency and ability to deliver comparable results; • identifying critical data quality and interoperability issues; and devising recommendations as to how to deal with these; • working with key industry and research infrastructure partners to gain insights, to develop networks and to advocate for longitudinal studies use of EPRs; • considering approaches for harmonising EPR information to support cross-cohort comparison studies; • identifying training/capacity needs and gaps in provision; • working with key industry and health sector partners to consider the impact on longitudinal studies of planned and future changes in health care informatics (e.g. patient access to their own health care EPRs); • writing a position paper summarising our findings and hosting a knowledge exchange workshop to disseminate our findings. This application seeks support for a series of workshops and resource to write the position paper. The programme focuses on data science issues rather than governance issues. |
| Impact | One workshop held. Wood N, Bann D, Hardy R, Gale C, Goodman A, Crawford C, Stafford M Childhood socioeconomic position and adult mental wellbeing: Evidence from four British birth cohort studies. PLoS One. 2017 Oct 25;12(10):e0185798. PMID:29069091 PMC5656308 |
| Start Year | 2017 |
| Description | CLOSER innovation Bid - Andy Boyd |
| Organisation | Millennium Cohort Study (MCS) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | • establishing an expert working group, comprising studies who have extracted EPRs and those with active plans to do so; • developing, with industry partners, a standard specification for data extracts which is optimised for efficiency, transparency and ability to deliver comparable results; • identifying critical data quality and interoperability issues; and devising recommendations as to how to deal with these; • working with key industry and research infrastructure partners to gain insights, to develop networks and to advocate for longitudinal studies use of EPRs; • considering approaches for harmonising EPR information to support cross-cohort comparison studies; • identifying training/capacity needs and gaps in provision; • working with key industry and health sector partners to consider the impact on longitudinal studies of planned and future changes in health care informatics (e.g. patient access to their own health care EPRs); • writing a position paper summarising our findings and hosting a knowledge exchange workshop to disseminate our findings. This application seeks support for a series of workshops and resource to write the position paper. The programme focuses on data science issues rather than governance issues. |
| Collaborator Contribution | • establishing an expert working group, comprising studies who have extracted EPRs and those with active plans to do so; • developing, with industry partners, a standard specification for data extracts which is optimised for efficiency, transparency and ability to deliver comparable results; • identifying critical data quality and interoperability issues; and devising recommendations as to how to deal with these; • working with key industry and research infrastructure partners to gain insights, to develop networks and to advocate for longitudinal studies use of EPRs; • considering approaches for harmonising EPR information to support cross-cohort comparison studies; • identifying training/capacity needs and gaps in provision; • working with key industry and health sector partners to consider the impact on longitudinal studies of planned and future changes in health care informatics (e.g. patient access to their own health care EPRs); • writing a position paper summarising our findings and hosting a knowledge exchange workshop to disseminate our findings. This application seeks support for a series of workshops and resource to write the position paper. The programme focuses on data science issues rather than governance issues. |
| Impact | One workshop held. Wood N, Bann D, Hardy R, Gale C, Goodman A, Crawford C, Stafford M Childhood socioeconomic position and adult mental wellbeing: Evidence from four British birth cohort studies. PLoS One. 2017 Oct 25;12(10):e0185798. PMID:29069091 PMC5656308 |
| Start Year | 2017 |
| Description | CLOSER innovation Bid - Andy Boyd |
| Organisation | UK Biobank |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | • establishing an expert working group, comprising studies who have extracted EPRs and those with active plans to do so; • developing, with industry partners, a standard specification for data extracts which is optimised for efficiency, transparency and ability to deliver comparable results; • identifying critical data quality and interoperability issues; and devising recommendations as to how to deal with these; • working with key industry and research infrastructure partners to gain insights, to develop networks and to advocate for longitudinal studies use of EPRs; • considering approaches for harmonising EPR information to support cross-cohort comparison studies; • identifying training/capacity needs and gaps in provision; • working with key industry and health sector partners to consider the impact on longitudinal studies of planned and future changes in health care informatics (e.g. patient access to their own health care EPRs); • writing a position paper summarising our findings and hosting a knowledge exchange workshop to disseminate our findings. This application seeks support for a series of workshops and resource to write the position paper. The programme focuses on data science issues rather than governance issues. |
| Collaborator Contribution | • establishing an expert working group, comprising studies who have extracted EPRs and those with active plans to do so; • developing, with industry partners, a standard specification for data extracts which is optimised for efficiency, transparency and ability to deliver comparable results; • identifying critical data quality and interoperability issues; and devising recommendations as to how to deal with these; • working with key industry and research infrastructure partners to gain insights, to develop networks and to advocate for longitudinal studies use of EPRs; • considering approaches for harmonising EPR information to support cross-cohort comparison studies; • identifying training/capacity needs and gaps in provision; • working with key industry and health sector partners to consider the impact on longitudinal studies of planned and future changes in health care informatics (e.g. patient access to their own health care EPRs); • writing a position paper summarising our findings and hosting a knowledge exchange workshop to disseminate our findings. This application seeks support for a series of workshops and resource to write the position paper. The programme focuses on data science issues rather than governance issues. |
| Impact | One workshop held. Wood N, Bann D, Hardy R, Gale C, Goodman A, Crawford C, Stafford M Childhood socioeconomic position and adult mental wellbeing: Evidence from four British birth cohort studies. PLoS One. 2017 Oct 25;12(10):e0185798. PMID:29069091 PMC5656308 |
| Start Year | 2017 |
| Description | CLOSER innovation Bid - Andy Boyd |
| Organisation | University of Bristol |
| Department | Avon Longitudinal Study of Parents and Children (ALSPAC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | • establishing an expert working group, comprising studies who have extracted EPRs and those with active plans to do so; • developing, with industry partners, a standard specification for data extracts which is optimised for efficiency, transparency and ability to deliver comparable results; • identifying critical data quality and interoperability issues; and devising recommendations as to how to deal with these; • working with key industry and research infrastructure partners to gain insights, to develop networks and to advocate for longitudinal studies use of EPRs; • considering approaches for harmonising EPR information to support cross-cohort comparison studies; • identifying training/capacity needs and gaps in provision; • working with key industry and health sector partners to consider the impact on longitudinal studies of planned and future changes in health care informatics (e.g. patient access to their own health care EPRs); • writing a position paper summarising our findings and hosting a knowledge exchange workshop to disseminate our findings. This application seeks support for a series of workshops and resource to write the position paper. The programme focuses on data science issues rather than governance issues. |
| Collaborator Contribution | • establishing an expert working group, comprising studies who have extracted EPRs and those with active plans to do so; • developing, with industry partners, a standard specification for data extracts which is optimised for efficiency, transparency and ability to deliver comparable results; • identifying critical data quality and interoperability issues; and devising recommendations as to how to deal with these; • working with key industry and research infrastructure partners to gain insights, to develop networks and to advocate for longitudinal studies use of EPRs; • considering approaches for harmonising EPR information to support cross-cohort comparison studies; • identifying training/capacity needs and gaps in provision; • working with key industry and health sector partners to consider the impact on longitudinal studies of planned and future changes in health care informatics (e.g. patient access to their own health care EPRs); • writing a position paper summarising our findings and hosting a knowledge exchange workshop to disseminate our findings. This application seeks support for a series of workshops and resource to write the position paper. The programme focuses on data science issues rather than governance issues. |
| Impact | One workshop held. Wood N, Bann D, Hardy R, Gale C, Goodman A, Crawford C, Stafford M Childhood socioeconomic position and adult mental wellbeing: Evidence from four British birth cohort studies. PLoS One. 2017 Oct 25;12(10):e0185798. PMID:29069091 PMC5656308 |
| Start Year | 2017 |
| Description | Collaboration on life course theory and methods |
| Organisation | King's College London |
| Department | Institute of Psychiatry, Psychology & Neuroscience |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Scientific leads on study design and drafting manuscripts vary, often involves data sharing, always analysis, interpretation and revision of manuscripts |
| Collaborator Contribution | co-editing book on life course methodscollaboration on statistical life course methodscollaboration on statistical life course theory and methodsjoint drafting and revising manuscripts |
| Impact | methods book and chapters 16306313 De Stavola et al AJE 2006 19028777 Mishra GD, Ben-Shlomo Y, Kuh D (in press) Life course approach to health behaviors: theory and methods. In Eds A. Steptoe et al. Handbook of Behavioral Medicine: Methods and Applications. Springer Power and Kuh 2006 Life course development of unequal health. In J Siegrist, M Marmot (Eds) Socioeconomic position and health: new explanations and their policy implications. Oxford University Press SMILE II grant application was not funded Ben Shlomo IJE review PMID: 27880685 Tilling PMID:27880690 Use and misuse of life course methods Howe PMID: 27681097 Mediation analysis and structured life course approach Smith PMID: 27371628 A structure approach to hypotheses |
| Start Year | 2006 |
| Description | Collaboration on life course theory and methods |
| Organisation | London School of Hygiene and Tropical Medicine (LSHTM) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Scientific leads on study design and drafting manuscripts vary, often involves data sharing, always analysis, interpretation and revision of manuscripts |
| Collaborator Contribution | co-editing book on life course methodscollaboration on statistical life course methodscollaboration on statistical life course theory and methodsjoint drafting and revising manuscripts |
| Impact | methods book and chapters 16306313 De Stavola et al AJE 2006 19028777 Mishra GD, Ben-Shlomo Y, Kuh D (in press) Life course approach to health behaviors: theory and methods. In Eds A. Steptoe et al. Handbook of Behavioral Medicine: Methods and Applications. Springer Power and Kuh 2006 Life course development of unequal health. In J Siegrist, M Marmot (Eds) Socioeconomic position and health: new explanations and their policy implications. Oxford University Press SMILE II grant application was not funded Ben Shlomo IJE review PMID: 27880685 Tilling PMID:27880690 Use and misuse of life course methods Howe PMID: 27681097 Mediation analysis and structured life course approach Smith PMID: 27371628 A structure approach to hypotheses |
| Start Year | 2006 |
| Description | Collaboration on life course theory and methods |
| Organisation | University College London |
| Department | Institute of Child Health |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Scientific leads on study design and drafting manuscripts vary, often involves data sharing, always analysis, interpretation and revision of manuscripts |
| Collaborator Contribution | co-editing book on life course methodscollaboration on statistical life course methodscollaboration on statistical life course theory and methodsjoint drafting and revising manuscripts |
| Impact | methods book and chapters 16306313 De Stavola et al AJE 2006 19028777 Mishra GD, Ben-Shlomo Y, Kuh D (in press) Life course approach to health behaviors: theory and methods. In Eds A. Steptoe et al. Handbook of Behavioral Medicine: Methods and Applications. Springer Power and Kuh 2006 Life course development of unequal health. In J Siegrist, M Marmot (Eds) Socioeconomic position and health: new explanations and their policy implications. Oxford University Press SMILE II grant application was not funded Ben Shlomo IJE review PMID: 27880685 Tilling PMID:27880690 Use and misuse of life course methods Howe PMID: 27681097 Mediation analysis and structured life course approach Smith PMID: 27371628 A structure approach to hypotheses |
| Start Year | 2006 |
| Description | Collaboration on life course theory and methods |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Scientific leads on study design and drafting manuscripts vary, often involves data sharing, always analysis, interpretation and revision of manuscripts |
| Collaborator Contribution | co-editing book on life course methodscollaboration on statistical life course methodscollaboration on statistical life course theory and methodsjoint drafting and revising manuscripts |
| Impact | methods book and chapters 16306313 De Stavola et al AJE 2006 19028777 Mishra GD, Ben-Shlomo Y, Kuh D (in press) Life course approach to health behaviors: theory and methods. In Eds A. Steptoe et al. Handbook of Behavioral Medicine: Methods and Applications. Springer Power and Kuh 2006 Life course development of unequal health. In J Siegrist, M Marmot (Eds) Socioeconomic position and health: new explanations and their policy implications. Oxford University Press SMILE II grant application was not funded Ben Shlomo IJE review PMID: 27880685 Tilling PMID:27880690 Use and misuse of life course methods Howe PMID: 27681097 Mediation analysis and structured life course approach Smith PMID: 27371628 A structure approach to hypotheses |
| Start Year | 2006 |
| Description | Collaboration on life course theory and methods |
| Organisation | University of Manchester |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Scientific leads on study design and drafting manuscripts vary, often involves data sharing, always analysis, interpretation and revision of manuscripts |
| Collaborator Contribution | co-editing book on life course methodscollaboration on statistical life course methodscollaboration on statistical life course theory and methodsjoint drafting and revising manuscripts |
| Impact | methods book and chapters 16306313 De Stavola et al AJE 2006 19028777 Mishra GD, Ben-Shlomo Y, Kuh D (in press) Life course approach to health behaviors: theory and methods. In Eds A. Steptoe et al. Handbook of Behavioral Medicine: Methods and Applications. Springer Power and Kuh 2006 Life course development of unequal health. In J Siegrist, M Marmot (Eds) Socioeconomic position and health: new explanations and their policy implications. Oxford University Press SMILE II grant application was not funded Ben Shlomo IJE review PMID: 27880685 Tilling PMID:27880690 Use and misuse of life course methods Howe PMID: 27681097 Mediation analysis and structured life course approach Smith PMID: 27371628 A structure approach to hypotheses |
| Start Year | 2006 |
| Description | Collaboration with National Cancer Institute, NIH |
| Organisation | National Institutes of Health (NIH) |
| Department | National Cancer Institute (NCI) |
| Country | United States |
| Sector | Public |
| PI Contribution | Data analysis, expertise, contributing to research papers |
| Collaborator Contribution | Data analysis, expertise, contributing to research papers |
| Impact | PMID 26930450 Zhou |
| Start Year | 2015 |
| Description | Collaboration with Queens Square - Polio |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Contributions will include providing data, data analysis, research advice, publication writing, grant applications, editing manuscripts and knowledge exchange |
| Collaborator Contribution | Contributions will include data analysis, research advice, publication writing, grant applications, editing manuscripts and knowledge exchange |
| Impact | Grant submitted to Medical Research Foundation |
| Start Year | 2014 |
| Description | Collaboration with TC Institute of Child Health |
| Organisation | University College London |
| Department | Institute of Child Health |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We are collaborating on a recently obtained grant developing and applying the SITAR method of growth curve analysis for translational exposures and life course outcomes in human growth assessment. We initially plan to relate the derived parameters to genetic obesity-risk-allele scores and subsequently to health outcomes. Providing NSHD data and expertise |
| Collaborator Contribution | Data analysis, interpretation, drafting and revision of papers. Providing methodological expertise. |
| Impact | Funding for grant application - Developing and applying the SITAR method of growth curve analysis for translational exposures and life course outcomes in human growth assessment. Cole: PMID:27466311 Using SITAR to relate pubertal growth to bone health in later life: the MRC National Survey of Health and Development Kuh: PMID: 27401728 Puberty and bone paper. Variables derived as part of this collaboration are still being used in analysis |
| Start Year | 2012 |
| Description | Collaboration with UCL Department of Statistical Science |
| Organisation | University College London |
| Department | Department of Statistical Science |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | One of our new Programme Leader Tracks collaborates with another researcher in the Department of Statistical Science. The CDF used to work with this PI at Cambridge and this collaboration has continued since moving to the Unit. Contributions include data analysis, publication writing, grant applications and editing manuscripts. |
| Collaborator Contribution | Contributions include data analysis, publication writing, grant applications and editing manuscripts. |
| Impact | Grant application 'Optimal design parameters for individual change point models in dementia and ageing research' submitted Publications 23471297 23276221 23136147 PI on grant submitted. Optimal design parameters for individual change point models in dementia and ageing research. Submitted to MRC methodology Board. Co-Pi on grant not funded after first attempt. Analysing cognitive function in the older population: joint latent class models for change and survival. Submitted to MRC methodology board |
| Start Year | 2013 |
| Description | Collaborations on genetics NES |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | NSHD data sharing, analysis, interpretation, drafting and revision of papers |
| Collaborator Contribution | Prof Aroon Hingorani Expertise in genetics of respiratory functionexpertise in genetics and respiratory function Dallas Swallow provides expertise from UCL Research Department of Genetics, Evolution and Environment |
| Impact | 19254294 Black et al 16759176 Rousseau et al 23551418 Johnson et al 25086287 Horsfall et al |
| Start Year | 2006 |
| Description | Collaborations on genetics NES |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | NSHD data sharing, analysis, interpretation, drafting and revision of papers |
| Collaborator Contribution | Prof Aroon Hingorani Expertise in genetics of respiratory functionexpertise in genetics and respiratory function Dallas Swallow provides expertise from UCL Research Department of Genetics, Evolution and Environment |
| Impact | 19254294 Black et al 16759176 Rousseau et al 23551418 Johnson et al 25086287 Horsfall et al |
| Start Year | 2006 |
| Description | Collaborations on genetics NES |
| Organisation | University of Southampton |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | NSHD data sharing, analysis, interpretation, drafting and revision of papers |
| Collaborator Contribution | Prof Aroon Hingorani Expertise in genetics of respiratory functionexpertise in genetics and respiratory function Dallas Swallow provides expertise from UCL Research Department of Genetics, Evolution and Environment |
| Impact | 19254294 Black et al 16759176 Rousseau et al 23551418 Johnson et al 25086287 Horsfall et al |
| Start Year | 2006 |
| Description | Endocrine Senescence collaboration |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | (1) To relate IGF-1 and testosterone, cross-sectionally and longitudinally, to measures of bone and muscle mass, osteoporosis and sarcopenia, and physical and cognitive performance, and (2) to assess whether these hormones are stronger predictors of these ageing outcomes when used together, or in combination with measures of cortisol regulation and thyroid function. Longer-term plans: To undertake a cross cohort study to examine the role of IGF-1 for maintaining healthy trajectories of physical capability. NSHD data sharing, analysis, interpretation, drafting and revision of papers |
| Collaborator Contribution | Writing grant applications, joint scientific leads on study design and drafting manuscripts, student supervision analysis, interpretation and revision of manuscripts. |
| Impact | A grant application was written for this collaboration. Numerous biological assays including IGF have been funded and will be completed by our collaborators by March 2013. A CDF post starting in January 2013 will be jointly supervised by one of these collaborators. Two papers are in progress Two papers have been revised and resubmitted - Testosterone and body composition and IGF and obesity PMID 25645314,25875330,26053924,26588434 |
| Start Year | 2012 |
| Description | Endocrine Senescence collaboration |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | (1) To relate IGF-1 and testosterone, cross-sectionally and longitudinally, to measures of bone and muscle mass, osteoporosis and sarcopenia, and physical and cognitive performance, and (2) to assess whether these hormones are stronger predictors of these ageing outcomes when used together, or in combination with measures of cortisol regulation and thyroid function. Longer-term plans: To undertake a cross cohort study to examine the role of IGF-1 for maintaining healthy trajectories of physical capability. NSHD data sharing, analysis, interpretation, drafting and revision of papers |
| Collaborator Contribution | Writing grant applications, joint scientific leads on study design and drafting manuscripts, student supervision analysis, interpretation and revision of manuscripts. |
| Impact | A grant application was written for this collaboration. Numerous biological assays including IGF have been funded and will be completed by our collaborators by March 2013. A CDF post starting in January 2013 will be jointly supervised by one of these collaborators. Two papers are in progress Two papers have been revised and resubmitted - Testosterone and body composition and IGF and obesity PMID 25645314,25875330,26053924,26588434 |
| Start Year | 2012 |
| Description | Endocrine Senescence collaboration |
| Organisation | University of Manchester |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | (1) To relate IGF-1 and testosterone, cross-sectionally and longitudinally, to measures of bone and muscle mass, osteoporosis and sarcopenia, and physical and cognitive performance, and (2) to assess whether these hormones are stronger predictors of these ageing outcomes when used together, or in combination with measures of cortisol regulation and thyroid function. Longer-term plans: To undertake a cross cohort study to examine the role of IGF-1 for maintaining healthy trajectories of physical capability. NSHD data sharing, analysis, interpretation, drafting and revision of papers |
| Collaborator Contribution | Writing grant applications, joint scientific leads on study design and drafting manuscripts, student supervision analysis, interpretation and revision of manuscripts. |
| Impact | A grant application was written for this collaboration. Numerous biological assays including IGF have been funded and will be completed by our collaborators by March 2013. A CDF post starting in January 2013 will be jointly supervised by one of these collaborators. Two papers are in progress Two papers have been revised and resubmitted - Testosterone and body composition and IGF and obesity PMID 25645314,25875330,26053924,26588434 |
| Start Year | 2012 |
| Description | Endocrine Senescence collaboration |
| Organisation | University of Southampton |
| Department | MRC Lifecourse Epidemiology Unit |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | (1) To relate IGF-1 and testosterone, cross-sectionally and longitudinally, to measures of bone and muscle mass, osteoporosis and sarcopenia, and physical and cognitive performance, and (2) to assess whether these hormones are stronger predictors of these ageing outcomes when used together, or in combination with measures of cortisol regulation and thyroid function. Longer-term plans: To undertake a cross cohort study to examine the role of IGF-1 for maintaining healthy trajectories of physical capability. NSHD data sharing, analysis, interpretation, drafting and revision of papers |
| Collaborator Contribution | Writing grant applications, joint scientific leads on study design and drafting manuscripts, student supervision analysis, interpretation and revision of manuscripts. |
| Impact | A grant application was written for this collaboration. Numerous biological assays including IGF have been funded and will be completed by our collaborators by March 2013. A CDF post starting in January 2013 will be jointly supervised by one of these collaborators. Two papers are in progress Two papers have been revised and resubmitted - Testosterone and body composition and IGF and obesity PMID 25645314,25875330,26053924,26588434 |
| Start Year | 2012 |
| Description | Epigenetics Kings |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Epigenetics response to social and environmental cues in early life and over the life course: impact on health ageing in UK population-based cohorts. Contribution of NSHD data, analysis, writing papers |
| Collaborator Contribution | Epigenetics response to social and environmental cues in early life and over the life course: impact on health ageing in UK population-based cohorts. Contribution of other population based data, analysis, writing papers |
| Impact | New staff appointment 2 abstracts - WT epigenomics of common disease and and IEA World Congress Maddock. Impact of body size, nutrition and socioeconomic position in early life on the epigenome: A systematic review protocol. PMID: 28679412 As part of the ESRC-funded epigenetics grant we have generated four large-scale epigenetic datasets from the TwinsUK cohort, from the NSHD (1946 birth cohort), from the NCDS cohort (1958 birth cohort), and from the 1970 birth cohort. We recently generated the DNA methylation datasets and are still processing the data for quality control purposes. Once the analyses are complete we plan to make the anonymised datasets publicly available upon publication, in 2018. At the moment, the methylation from TwinsUK and NSHD are available through managed access and the data from 1958 and 1970 will be made available in 2018. The first immediate benefit of these data will be to the academic community in terms of providing large-scale methylome data for researchers in epigenetics to explore in the context of their own research hypotheses. Maddock, J, Wulaningsih, W, Castillo Fernandez, J, Wong, A, Ploubidis, GB, Goodman, A, Bell, J, Kuh, D, Hardy, R. Associations between body size, nutrition and socioeconomic position in early life and the epigenome: A systematic review. PLoS One 2018 Aug 10;13(8):e0201672. doi: 10.1371/journal.pone.0201672. eCollection 2018 Maddock, J, Zhou A, Cavadino A, Kuzma E, Bao Y, Smart MC, Saum KU, Schottker B, Engmann J, Kjærgaard M, Karhunen V, Zhan Y, Lehtimäki T, Rovio SP, Byberg L, Lahti J, Marques-Vidal P, Sen A, Perna L, Schirmer H, Singh-Manoux A, Auvinen J, Hutri-Kähönen N, Kähönen M, Kilander L, Räikkönen K, Melhus H, Ingelsson E, Guessous I, Petrovic KE, Schmidt H, Schmidt R, Vollenweider P, Lind L, Eriksson JG, Michaëlsson K, Raitakari OT, Hägg S, Pedersen NL, Herzig KH, Järvelin MR, Veijola J, Kivimaki M, Jorde R, Brenner H, Kumari M, Power C, Llewellyn DJ, Hyppönen E. Vitamin D and cognitive function: A Mendelian randomisation study. Sci Rep. 2017 Oct 16;7(1):13230. PMID: 29038561 PMC5643555 Maddock, J, Wulaningsih, W, Hardy, R. Impact of body size, nutrition and socioeconomic position in early life on the epigenome: A systematic review protocol. Systematic Reviews. Jul 5;6(1):129. doi: 10.1186/s13643-017-0521-8. Maddock, J, Wulaningsih, W, Castillo Fernandez, J, Wong, A, Ploubidis, GB, Goodman, A, Bell, J, Kuh, D, Hardy, R. Associations between body size, nutrition and socioeconomic position in early life and the epigenome: A systematic review. PLoS One 2018 Aug 10;13(8):e0201672. doi: 10.1371/journal.pone.0201672. eCollection 2018. |
| Start Year | 2016 |
| Description | Incontinence collaboration (L Cardozza) |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provide life course expertise, complete data analysis, manuscript preparation |
| Collaborator Contribution | Provide expertise in incontinence research |
| Impact | Tsui A. Vascular risk factors for male and female urgency urinary incontinence at age 68 years from a British birth cohort study.PMID: 29512315 |
| Start Year | 2016 |
| Description | Insight 46 study |
| Organisation | University College London |
| Department | Institute of Neurology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | A subset of study members from NSHD will undergo positron emission tomography (PET) to detect early deposition of fibrillar beta-amyloid (Aß) and other misfolded proteins involved in the pathogenesis of Alzheimer's disease; (2) sensitive MRI techniques to measure early cortical and sub-cortical atrophy, cerebrovascular lesions, cerebral blood flow, and regional metabolic rate of oxygen. NSHD will coordinate the study and review the potential to add in additional assessments (auditory and visual) around this sub-study |
| Collaborator Contribution | The PET scans and MRI techniques will be carried out by collaborators at Queens Square. They will also interpret the the scans. Our collaborators are also helping the initial organisation/logistics of the study. |
| Impact | Funding from the Wolfson Foundation for a neuroimaging sub-study for 500 NSHD study members Grant application submitted but not successful to Welcome Trust Funding from ARUK for 3 day study manager and 1 day of senior study manager (128,000) Training, equipment and documents purchased/created Abstracts submitted to Alzheimer's Association International Conference, May 2017. 500 participants seen and wave 1 has been completed. Wave 2 is underway. Lane CA, Study protocol: Insight 46 - a neuroscience sub-study of the MRC National Survey of Health and Development.BMC Neurol. 2017 Apr 18;17(1):75. doi: 10.1186/s12883-017-0846-x. PMID:28420323 James SN, Lane CA, Parker TD, Lu K, Collins JD, Murray-Smith H, Byford M, Wong A, Keshavan A, Buchanan S, Keuss SE, Kuh D, Fox NC, Schott JM, Richards M. Using a birth cohort to study brain health and preclinical dementia: recruitment and participation rates in Insight 46. BMC Res Notes. 2018 Dec 13;11(1):885. doi: 10.1186/s13104-018-3995-0. PMID: 30545411 Lane C, Parker T, Macpherson K, Murray-Smith H, Cash D, Thomas D, Byford M, Wong A, Modat M, Malone I, Klimova J, Burgos N, Hutel M, Melbourne A, Donnachie E, Esser P, Dawes H, Husain M, Hoskote C, Shah S, + others, Frost C, Hardy R, Bras J, Hardy J, Zhang H, Zetterberg H, Ourselin S, Sharma N, Crutch SJ, Kuh D, Richards M*, Fox NC*, Schott JM* (joint senior). Study Protocol: Insight 46, a neuro-imaging sub-study of the MRC National Survey for Health and Development 1946 Birth cohort. BMC Neurology 2017 Apr 18;17(1):75. doi: 10.1186/s12883-017-0846-x. |
| Start Year | 2012 |
| Description | Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | UCL is the main partner for this collaboration NSHD data sharing, revision of manuscripts |
| Collaborator Contribution | Analysis and interpretation of NSHD (and other) data Contribute to the scientific development of the collaboration Preparation of research papers |
| Impact | PMID 22421340 |
| Start Year | 2011 |
| Description | Life course determinants of kidney function |
| Organisation | London School of Hygiene and Tropical Medicine (LSHTM) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Clinical and epidemiological expertise as part of the scientific collaboration, new NSHD clinical data on renal function to be used in conjunction with existing NSHD life course data |
| Collaborator Contribution | By starting a long term collaboration with Dr Dorothea Nitsch, a nephrologist and a postdoctoral scientist we will expand the clinical and analytical skills in the area of research on renal function |
| Impact | Collaboration led to grant from KRUK on 'exploring early life course determinants of chronic kidney disease' |
| Start Year | 2009 |
| Description | MRC guidelines on biomarkers of healthy ageing |
| Organisation | Newcastle University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Three LHA scientists contributed to the creation of the new MRC guidelines on biomarkers of healthy ageing and also helped to organise a workshop on the subject. |
| Collaborator Contribution | The external collaborators also contributed to the creation of the new MRC guidelines on biomarkers of healthy ageing and helped to organise a workshop on the subject. |
| Impact | Creation of the new MRC guidelines is still in progress - drafts are being circulated Kuh et al PMID: 24456831 PMID: 26373927 |
| Start Year | 2011 |
| Description | MRC guidelines on biomarkers of healthy ageing |
| Organisation | University of Birmingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Three LHA scientists contributed to the creation of the new MRC guidelines on biomarkers of healthy ageing and also helped to organise a workshop on the subject. |
| Collaborator Contribution | The external collaborators also contributed to the creation of the new MRC guidelines on biomarkers of healthy ageing and helped to organise a workshop on the subject. |
| Impact | Creation of the new MRC guidelines is still in progress - drafts are being circulated Kuh et al PMID: 24456831 PMID: 26373927 |
| Start Year | 2011 |
| Description | MRC guidelines on biomarkers of healthy ageing |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Three LHA scientists contributed to the creation of the new MRC guidelines on biomarkers of healthy ageing and also helped to organise a workshop on the subject. |
| Collaborator Contribution | The external collaborators also contributed to the creation of the new MRC guidelines on biomarkers of healthy ageing and helped to organise a workshop on the subject. |
| Impact | Creation of the new MRC guidelines is still in progress - drafts are being circulated Kuh et al PMID: 24456831 PMID: 26373927 |
| Start Year | 2011 |
| Description | MRC guidelines on biomarkers of healthy ageing |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Three LHA scientists contributed to the creation of the new MRC guidelines on biomarkers of healthy ageing and also helped to organise a workshop on the subject. |
| Collaborator Contribution | The external collaborators also contributed to the creation of the new MRC guidelines on biomarkers of healthy ageing and helped to organise a workshop on the subject. |
| Impact | Creation of the new MRC guidelines is still in progress - drafts are being circulated Kuh et al PMID: 24456831 PMID: 26373927 |
| Start Year | 2011 |
| Description | Montpellier Collaboration |
| Organisation | University of Montpellier |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Contributions will include providing data, data analysis, research advice, organising meetings, publication writing, grant applications, editing manuscripts and knowledge exchange |
| Collaborator Contribution | Contributions will include providing data, data analysis, research advice, organising meetings, publication writing, grant applications, editing manuscripts and knowledge exchange |
| Impact | Paper accepted in Thorax Meeting organised - Operative definition of active and healthy Ageing Oct 2014 |
| Start Year | 2013 |
| Description | NCD Risk Factor Collaboration |
| Organisation | Imperial College London |
| Department | Imperial College Trust |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Provide NSHD data and advice on manuscript preparation and analysis |
| Collaborator Contribution | Analysis of data and creation of manuscripts |
| Impact | PMID 27061677 Trends in diabetes PMID 27458798 Adult human height PMID 27115820 Trends in adult BMI PMID 27863813 Trends in blood pressure NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in body mass index, underweight, overweight and obesity from 1975 to 2016: a pooled analysis of 2,416 population-based measurement studies with 128.9 million children, adolescents and adults.PMID: 29029897 2017 Dec 16;390(10113):2627-2642. doi: 10.1016/S0140-6736(17)32129-3. NCD Risk Factor Collaboration 'Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants' International Journal of Epidemiology. . 2018 Mar 19. doi: 10.1093/ije/dyy016. [Epub ahead of print] Most recent wave of data added in |
| Start Year | 2016 |
| Description | PHSRN Network |
| Organisation | University of Cambridge |
| Department | MRC Epidemiology Unit |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Member of the PHSRN Network. Comment on proposals, help with organisation of events/training, work together on research projects |
| Collaborator Contribution | The overall goals for the MRC Population Health Sciences Network (PHSRN) remain 1. To encourage collaborative research on key questions in the population health sciences. 2. To add value to members' individual work programmes and the MRC's overall investment in the population health sciences. 3. To provide a forum for discussing and responding to research and policy issues relating to population health. 4. To build research capacity in the population health sciences. The specific objectives of the next phase of PHSRN will be 1. To promote the development and dissemination of best practice in population health science through a continued programme of methodological knowledge exchange working collaboratively with other networks and stakeholders. 2. To lead the development of a series of frontier workshops aimed at synergising opportunities for the development of collaborative working on large-scale public health challenges. 3. To work collaboratively with other networks and groups to establish a UK flagship conference on methods and challenges in population health. |
| Impact | Renewal of PHSRN funding grant application submitted |
| Start Year | 2014 |
| Description | Secondment to MRC Research Data Support Service (DSS) Project |
| Organisation | Medical Research Council (MRC) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Secondment to the MRC Research Data Support Service (DSS) Project. One is Programme Manager for one year 50% FTE 1. Maximise the use of the Gateway by researchers by: - improving promotion and visibility of the Gateway - improving the experience of accessing and using the Gateway - increasing the publication of informative metadata into Gateway by engaging a further 10+ MRC 'strategic' cohorts - improving the quality of existing study information and metadata - facilitating easy acquisition of new sets of study and variable descriptions 2. Validate the utility of the Gateway to researchers by: - ensuring new uses and outputs are documented by studies - collecting feedback from a range of users 3. Coordinate development, validation and implementation of metadata standards and tools by: - working with CLOSER (ESRC / MRC funded Cohort and Longitudinal Studies Enhancement Resources) and UK Data Service (UKDS) for the Population Health Science (PHS) community - working with MRC Head Office to ensure coordination with related metadata initiatives for patient / clinical cohorts and data discovery and sharing with omics / bioinformatics imaging and e-health. - engaging with research, informatics and data management communities and with stakeholder organisations e.g. JISC, EBI - aligning DSS and CLOSER search platforms within a wider system of interoperable data and tissue services. 4. Promote and support the implementation of MRC Research Data policy by: - enabling studies to publish metadata by providing initial assistance and tools for ingest - providing examples of good practice - identifying needs and feeding into the wider MRC policy |
| Collaborator Contribution | Members of the MRC will work with the seconded staff to complete the project and objectives listed in the above contribution section |
| Impact | none |
| Start Year | 2013 |
| Description | UCLEB cohort collaboration for genetic research |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | NSHD data sharing and epideomiological experitise |
| Collaborator Contribution | Maximising research potential of NSHD Prof Aroon Hinorani brings in CVD and genetic skills and manages the collaboration with several CVD cohort studies at UCL and Edinburgh, including NSHD. Data sharing |
| Impact | UCL Biomedical Research Centre High Impact Grant awarded BHF programme grant under review 23977022 White 26781229 Neusch 25979724 Talmund 25475436 White 26781229 Beaney 27549350 Morris 27365493 Prins 27327646 Beaney KE. Functional analysis of the coronary heart disease risk locus on chromosome 21q22. PMID:28458444 PMC5387827 Dale C. Causal Associations of Adiposity and Body Fat Distribution with Coronary Heart Disease, Stroke Subtypes and Type 2 Diabetes: A Mendelian Randomization Analysis. PMID: 28500271 PMC5515354 Fairoozy R. Identifying Low Density Lipoprotein Cholesterol Associated Variants in the Annexin A2 (ANXA2) Gene. PMID:28456096 PMC5446264 Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, Kavousi M, Dale C, Smith AV, Hofer E, van Leeuwen EM, Nolte IM, Lu L, Scholz M, Sargurupremraj M, Pitkänen N, Franzén O, Joshi PK, Noordam R, Marioni RE, Hwang SJ, Musani SK, Schminke U, Palmas W, Isaacs A, Correa A, Zonderman AB, Hofman A, Teumer A, Cox AJ, Uitterlinden AG, Wong A, Smit AJ, Newman AB, Britton A, Ruusalepp A, Sennblad B, Hedblad B, Pasaniuc B, Penninx BW, Langefeld CD, Wassel CL, Tzourio C, Fava C, Baldassarre D, O'Leary DH, Teupser D, Kuh D, Tremoli E, Mannarino E, Grossi E, Boerwinkle E, Schadt EE, Ingelsson E, Veglia F, Rivadeneira F, Beutner F, Chauhan G, Heiss G, Snieder H, Campbell H, Völzke H, Markus HS, Deary IJ, Jukema JW, de Graaf J, Price J, Pott J, Hopewell JC, Liang J, Thiery J, Engmann J, Gertow K, Rice K, Taylor KD, Dhana K, Kiemeney LALM, Lind L, Raffield LM, Launer LJ, Holdt LM, Dörr M, Dichgans M, Traylor M, Sitzer M, Kumari M, Kivimaki M, Nalls MA, Melander O, Raitakari O, Franco OH, Rueda-Ochoa OL, Roussos P, Whincup PH, Amouyel P, Giral P, Anugu P, Wong Q, Malik R, Rauramaa R, Burkhardt R, Hardy R, Schmidt R, de Mutsert R, Morris RW, Strawbridge RJ, Wannamethee SG, Hägg S, Shah S, McLachlan S, Trompet S, Seshadri S, Kurl S, Heckbert SR, Ring S, Harris TB, Lehtimäki T, Galesloot TE, Shah T, de Faire U, Plagnol V, Rosamond WD, Post W, Zhu X, Zhang X, Guo X, Saba Y; MEGASTROKE Consortium, Dehghan A, Seldenrijk A, Morrison AC, Hamsten A, Psaty BM, van Duijn CM, Lawlor DA, Mook-Kanamori DO, Bowden DW, Schmidt H, Wilson JF, Wilson JG, Rotter JI, Wardlaw JM, Deanfield J, Halcox J, Lyytikäinen LP, Loeffler M, Evans MK, Debette S, Humphries SE, Völker U, Gudnason V, Hingorani AD, Björkegren JLM, Casas JP, O'Donnell CJ. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nat Commun. 2018 Dec 3;9(1):5141. doi: 10.1038/s41467-018-07340-5. PMID: 30510157 |
| Start Year | 2008 |
| Description | UCLEB cohort collaboration for genetic research |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | NSHD data sharing and epideomiological experitise |
| Collaborator Contribution | Maximising research potential of NSHD Prof Aroon Hinorani brings in CVD and genetic skills and manages the collaboration with several CVD cohort studies at UCL and Edinburgh, including NSHD. Data sharing |
| Impact | UCL Biomedical Research Centre High Impact Grant awarded BHF programme grant under review 23977022 White 26781229 Neusch 25979724 Talmund 25475436 White 26781229 Beaney 27549350 Morris 27365493 Prins 27327646 Beaney KE. Functional analysis of the coronary heart disease risk locus on chromosome 21q22. PMID:28458444 PMC5387827 Dale C. Causal Associations of Adiposity and Body Fat Distribution with Coronary Heart Disease, Stroke Subtypes and Type 2 Diabetes: A Mendelian Randomization Analysis. PMID: 28500271 PMC5515354 Fairoozy R. Identifying Low Density Lipoprotein Cholesterol Associated Variants in the Annexin A2 (ANXA2) Gene. PMID:28456096 PMC5446264 Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, Kavousi M, Dale C, Smith AV, Hofer E, van Leeuwen EM, Nolte IM, Lu L, Scholz M, Sargurupremraj M, Pitkänen N, Franzén O, Joshi PK, Noordam R, Marioni RE, Hwang SJ, Musani SK, Schminke U, Palmas W, Isaacs A, Correa A, Zonderman AB, Hofman A, Teumer A, Cox AJ, Uitterlinden AG, Wong A, Smit AJ, Newman AB, Britton A, Ruusalepp A, Sennblad B, Hedblad B, Pasaniuc B, Penninx BW, Langefeld CD, Wassel CL, Tzourio C, Fava C, Baldassarre D, O'Leary DH, Teupser D, Kuh D, Tremoli E, Mannarino E, Grossi E, Boerwinkle E, Schadt EE, Ingelsson E, Veglia F, Rivadeneira F, Beutner F, Chauhan G, Heiss G, Snieder H, Campbell H, Völzke H, Markus HS, Deary IJ, Jukema JW, de Graaf J, Price J, Pott J, Hopewell JC, Liang J, Thiery J, Engmann J, Gertow K, Rice K, Taylor KD, Dhana K, Kiemeney LALM, Lind L, Raffield LM, Launer LJ, Holdt LM, Dörr M, Dichgans M, Traylor M, Sitzer M, Kumari M, Kivimaki M, Nalls MA, Melander O, Raitakari O, Franco OH, Rueda-Ochoa OL, Roussos P, Whincup PH, Amouyel P, Giral P, Anugu P, Wong Q, Malik R, Rauramaa R, Burkhardt R, Hardy R, Schmidt R, de Mutsert R, Morris RW, Strawbridge RJ, Wannamethee SG, Hägg S, Shah S, McLachlan S, Trompet S, Seshadri S, Kurl S, Heckbert SR, Ring S, Harris TB, Lehtimäki T, Galesloot TE, Shah T, de Faire U, Plagnol V, Rosamond WD, Post W, Zhu X, Zhang X, Guo X, Saba Y; MEGASTROKE Consortium, Dehghan A, Seldenrijk A, Morrison AC, Hamsten A, Psaty BM, van Duijn CM, Lawlor DA, Mook-Kanamori DO, Bowden DW, Schmidt H, Wilson JF, Wilson JG, Rotter JI, Wardlaw JM, Deanfield J, Halcox J, Lyytikäinen LP, Loeffler M, Evans MK, Debette S, Humphries SE, Völker U, Gudnason V, Hingorani AD, Björkegren JLM, Casas JP, O'Donnell CJ. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nat Commun. 2018 Dec 3;9(1):5141. doi: 10.1038/s41467-018-07340-5. PMID: 30510157 |
| Start Year | 2008 |
| Description | UCLEB cohort collaboration for genetic research |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | NSHD data sharing and epideomiological experitise |
| Collaborator Contribution | Maximising research potential of NSHD Prof Aroon Hinorani brings in CVD and genetic skills and manages the collaboration with several CVD cohort studies at UCL and Edinburgh, including NSHD. Data sharing |
| Impact | UCL Biomedical Research Centre High Impact Grant awarded BHF programme grant under review 23977022 White 26781229 Neusch 25979724 Talmund 25475436 White 26781229 Beaney 27549350 Morris 27365493 Prins 27327646 Beaney KE. Functional analysis of the coronary heart disease risk locus on chromosome 21q22. PMID:28458444 PMC5387827 Dale C. Causal Associations of Adiposity and Body Fat Distribution with Coronary Heart Disease, Stroke Subtypes and Type 2 Diabetes: A Mendelian Randomization Analysis. PMID: 28500271 PMC5515354 Fairoozy R. Identifying Low Density Lipoprotein Cholesterol Associated Variants in the Annexin A2 (ANXA2) Gene. PMID:28456096 PMC5446264 Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, Kavousi M, Dale C, Smith AV, Hofer E, van Leeuwen EM, Nolte IM, Lu L, Scholz M, Sargurupremraj M, Pitkänen N, Franzén O, Joshi PK, Noordam R, Marioni RE, Hwang SJ, Musani SK, Schminke U, Palmas W, Isaacs A, Correa A, Zonderman AB, Hofman A, Teumer A, Cox AJ, Uitterlinden AG, Wong A, Smit AJ, Newman AB, Britton A, Ruusalepp A, Sennblad B, Hedblad B, Pasaniuc B, Penninx BW, Langefeld CD, Wassel CL, Tzourio C, Fava C, Baldassarre D, O'Leary DH, Teupser D, Kuh D, Tremoli E, Mannarino E, Grossi E, Boerwinkle E, Schadt EE, Ingelsson E, Veglia F, Rivadeneira F, Beutner F, Chauhan G, Heiss G, Snieder H, Campbell H, Völzke H, Markus HS, Deary IJ, Jukema JW, de Graaf J, Price J, Pott J, Hopewell JC, Liang J, Thiery J, Engmann J, Gertow K, Rice K, Taylor KD, Dhana K, Kiemeney LALM, Lind L, Raffield LM, Launer LJ, Holdt LM, Dörr M, Dichgans M, Traylor M, Sitzer M, Kumari M, Kivimaki M, Nalls MA, Melander O, Raitakari O, Franco OH, Rueda-Ochoa OL, Roussos P, Whincup PH, Amouyel P, Giral P, Anugu P, Wong Q, Malik R, Rauramaa R, Burkhardt R, Hardy R, Schmidt R, de Mutsert R, Morris RW, Strawbridge RJ, Wannamethee SG, Hägg S, Shah S, McLachlan S, Trompet S, Seshadri S, Kurl S, Heckbert SR, Ring S, Harris TB, Lehtimäki T, Galesloot TE, Shah T, de Faire U, Plagnol V, Rosamond WD, Post W, Zhu X, Zhang X, Guo X, Saba Y; MEGASTROKE Consortium, Dehghan A, Seldenrijk A, Morrison AC, Hamsten A, Psaty BM, van Duijn CM, Lawlor DA, Mook-Kanamori DO, Bowden DW, Schmidt H, Wilson JF, Wilson JG, Rotter JI, Wardlaw JM, Deanfield J, Halcox J, Lyytikäinen LP, Loeffler M, Evans MK, Debette S, Humphries SE, Völker U, Gudnason V, Hingorani AD, Björkegren JLM, Casas JP, O'Donnell CJ. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nat Commun. 2018 Dec 3;9(1):5141. doi: 10.1038/s41467-018-07340-5. PMID: 30510157 |
| Start Year | 2008 |
| Description | Vitamin D |
| Organisation | University College London |
| Department | Institute of Child Health |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We completed analysis on the genotyping that was done on NSHD study memebers |
| Collaborator Contribution | The UCL group paid for genotyping of NSHD samples and carried out meta analysis in collaboration with a number of cohort studies |
| Impact | Vimaleswaran et al PMID:24974252 |
| Start Year | 2011 |
| Title | New data sharing platform - Skylark |
| Description | Skylark is our new data sharing platform. Skylark is aimed at providing researchers with all the information they need to apply for survey data from the NSHD. Skylark is composed of two companion systems: A wiki (https://skylark.ucl.ac.uk) provides users with a detailed description of the study including all data collections across its 70+ years. The wiki includes: 1. background information about the NSHD; 2. all annotated questionnaires and other paper instruments; 3. a description of the major topics, including information on repeated measures and standard variables; 4. information about the variable search facility and guides on how to locate variables; 5. NSHD information governance; 6. a complete description of the NSHD data sharing process, including all the forms necessary to set up a data sharing agreement and submit a data access request. A variable search facility (https://skylark/ucl.ac.uk/Skylark) provides a platform to locate metadata covering more than 25,000 NSHD variables. Users will need to register, before they can log in to search for variables of interest, which can then be added to personal shopping baskets and saved. Following a successful data sharing application and satisfactory information security assessment, these baskets will then be processed by NSHD staff and the data sent out. This is different from our current data sharing platform, SWIFT, is that it is more secure, transparent and the process of data sharing will be more automated. Data applications are now all completed on line improvements are continuously being made to this platform |
| Type Of Technology | New/Improved Technique/Technology |
| Year Produced | 2018 |
| Impact | We are in the testing phase, with a full launch scheduled for end of September / beginning of October. |
| URL | https://skylark.ucl.ac.uk |
| Description | "Unclaimed" - Installation at the Barbican |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Installation at the Barbican 11th Feb to 3rd May: https://www.barbican.org.uk/whats-on/2019/event/unclaimed-the-liminal-space covered by: - BBC London - London Live - Evening Standard Follow-on events planned for Oxford, Sage Gateshead and maybe New York! |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.barbican.org.uk/whats-on/2019/event/unclaimed-the-liminal-space |
| Description | 'Seize the day' Life experiences through dance. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Seize the Day is a unique patient and public engagement event developed in collaboration with researchers from UCL, Movement for Hope (UCL SME), and Tanztheater Adrian Look dance company. The art-science dance performance explores stories of unexpected disease onset and how it changes person's perspective. The dance shares a journey through diagnosis, challenges, triumphs and hope. After the dance, there will be a question & answer session with researchers, dancers and patient-advocates |
| Year(s) Of Engagement Activity | 2016 |
| Description | 72nd birthday card workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Two workshops were held with ~20 school students (year 9 and year 13) to discuss the history of cohort studies and why they are important. Students were then asked to design a birthday card for our study members using collage. They used old memorabilia from the study. This was a collaboration between a collage artist and two historians from LSHTM. A number of birthday cards were created and two were chosen to send to our study members. As a result of this collaboration a research paper about the history of the NSHD is in progress as well as another public engagement event. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Article in Leonard Wolfson Experimental Neurology Centre newsletter about MND early diagnostic clinic |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Article in Leonard Wolfson Experimental Neurology Centre newsletter about MND early diagnostic clinic. Raised awareness of this clinic and the benefits of early diagnosis of MND |
| Year(s) Of Engagement Activity | 2016 |
| Description | Article on logitudinal studies in The Guardian |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | The Director was interviewed for an article about the importance of longitudinal studies Increased awareness of NSHD and longitudinal studies research and the benefits of it |
| Year(s) Of Engagement Activity | Pre-2006,2014 |
| Description | BBC breakfast news recording, BBC Radio 4 Piece and Telegraph article (print and online) about the neuroimaging clinical sub-study. |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Increased awareness of the NSHD and new neuroscience sub study. Resulted in 3 members of the study who had previously not bee in contact wishing to be involved again. |
| Year(s) Of Engagement Activity | 2015 |
| Description | CLSA Webinar Series: Aging is a lifelong and socially patterned process |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | CLSA Webinar Series: Aging is a lifelong and socially patterned process. Increased awareness of NSHD research. |
| Year(s) Of Engagement Activity | 2016 |
| Description | DELPHIC public debate |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Debate on management of cognitive impairment in acute hospitals. Purpose was to stimulate discussion on where priorities should be focussed. Impacts included raising profile of delirium as important issue in hospitals. |
| Year(s) Of Engagement Activity | 2017 |
| Description | DK featured in an article by Der Spiegel |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | DK was interviewed by the newspaper to discussed the MRC NSHD and the findings of the research over the past 70 years. |
| Year(s) Of Engagement Activity | 2016 |
| Description | DK featured in an article by the Daily Mail about how to age well |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Article specifically mentioned the NSHD so would have raised awareness of the cohort |
| Year(s) Of Engagement Activity | 2016 |
| Description | DK interviewed for DPUK newsletter |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | The Director of NSHD was interviewed for the DPUK newsletter to discuss how she achieved her various academic successes, the route she took to becoming a Professor, and the training and support she received during her career. |
| Year(s) Of Engagement Activity | 2016 |
| Description | DK spoke to BBC World in Action Radio Show about epigenetics and ageing |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | DK spoke to BBC World in Action Radio Show about epigenetics and ageing. Increased awareness of this topic and the use of cohorts in researching this area |
| Year(s) Of Engagement Activity | 2016 |
| Description | Dementia UK blog post about special debate on how dementia and delirium should be approached in acute hospital settings |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Blog post was written about a debate which a LHA clinician took part in to raise awareness of dementia and delirium. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Dementia UK debate and blog post about delirium |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dementia and delirium specialists from University College Hospital London, The Royal London Hospital and Dementia UK came together at the end of February for a special debate on how dementia and delirium should be approached in acute hospital settings. The event was organised by staff from University College Hospital and generated lots of interest. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.dementiauk.org/dementia-or-delirium-so-what/ |
| Description | Diana Kuh attended the launch of the neuroimaging sub-study -Insight 46 hosted by Alzheimer's Research UK - took part in a panel discussion. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | The discussion was recorded in a podcast .Increased awareness of the NSHD and new neuroscience sub study. Increased donations to ARUK through presenting to major donors |
| Year(s) Of Engagement Activity | 2015 |
| Description | Diana Kuh gave a presentation at the Islington University of the Third Age on 'A life course approach to healthy ageing'. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Increased awareness of NSHD and a life course approach to healthy ageing |
| Year(s) Of Engagement Activity | 2015 |
| Description | Diana Kuh took part in a radio show - The Agenda - on Wireless Radio (in partnership with Age UK) to speak about the NSHD and the neuroimaging study. |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Increased awareness of the NSHD to a new audience who have an active interest in healthy ageing. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Einstein's Garden at Green Man Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | • New story on MRC website about Einstein's garden at Green Man Festival - attribute to all programmes |
| Year(s) Of Engagement Activity | 2018 |
| Description | From paediatrics to geriatrics: insights on ageing from a 70 year old birth cohort study. Addingham Women's Institute. January 14th |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk to Addingham Women's Institute - From paediatrics to geriatrics: insights on ageing from a 70 year old birth cohort study. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Generations Apart Film |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | Generations apart film was created by NSHD and ALSPAC. The film featured study members taking about their shared experience of being part of a cohort study. There was also a film screening as part of MRC Festival of Medical Research. Around 50-60 people were present and there was a positive Q and A session afterwards with Diana Kuh, Lynn Molloy and 2 study members. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Green Man 2018 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Green Man 2018 - As part of this, with funding from MRC, researchers from UCL partnered with fanSHEN theatre company to create an activity to engage the public with findings from longitudinal life course research. The successful collaboration led to the development of "Life Course golf course"; part crazy golf, part insight into research from longitudinal cohort studies. In this activity, festival goers were recruited into the life course-themed six-hole golf course. Their caddy (research scientists) navigated them through the 'life course golf course' by discussing and describing how studying birth cohorts have helped us to understand how early life factors can affect later health outcomes. Over 1,500 adults and children successfully progressed through the course. With an audience made up of families, teenagers and adults who wouldn't normally attend a scientific event, it presented a fantastic opportunity to share about our research in a fun and creative way. We have had lots of positive feedback and have been approached by other universities and even the Science Museum to explore re-running the activity at future events |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.ucl.ac.uk/cardiovascular/research/population-science-and-experimental-medicine/mrc-unit-... |
| Description | Green Man Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Green Man Festival. Scientists from the Medical Research Council Unit for Lifelong Health and Ageing at UCL wanted to tell people all about their work- a UK birth cohort study of 5000 people who have been studied by the unit ever since they were born in 1946. Funded by the Wellcome Trust, artists helped to transform the study into 'Tangle', an activity designed to represent how scientists gather up the threads of many people's lives and weave them together to answer research questions. Festival goers were asked to contribute their data on eight variables the scientists examine, for example stress, memory, and health behaviours. Instead of filling out questionnaires, the participants got a piece of coloured fabric for each of their answers, which they wound onto a rope to create their "life course". Anything else that they thought was important in their lives they wrote onto a fabric luggage tag to share with everyone. More than 600 people came to talk to the scientists and make their own life course, which they then used to help answer a research question: "What is most important to your quality of life." Against the backdrop of Welsh mountains a tapestry frame stood displaying various answers such as, "health", "wealth" and "music" (well, it was a music festival). The new study members threaded their own life course into the section that represented them. It soon became obvious what was most important to their quality of life. |
| Year(s) Of Engagement Activity | 2017 |
| Description | HALCYon Project Summary Brochure |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | A plain english brochure was created which summarised the main findings from the HALCyon research programme. It has been disseminated to study members, on our website and the New Dynamics of Ageing website and at conferences. Increased awareness of the findings from the HALCyon programme and the cohorts that were used within this research programme |
| Year(s) Of Engagement Activity | 2014 |
| Description | HALCYon book launch |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | A book launch was arranged to promote the findings from the HALCyon research programme Shared knowledge of the HALCyon findings which were published in a book 'A life course approach to healthy ageing'. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Invited Talk: BIHS 2021 Resilience in Research |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Chloe Park gave an Invited Talk at the Young Investigators session of the BIHS meeting, Brighton, Sep 2021, on Resilience in Research |
| Year(s) Of Engagement Activity | 2021 |
| Description | Leyden Academy visit |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Talks were given by LHA researcher to visiting health professionals who were on a course run by the Leyden Academy in the Netherlands Increased awareness of the work of the Unit for Lifelong Health and Ageing and longitudinal studies |
| Year(s) Of Engagement Activity | 2014 |
| Description | Lost & Found (Now called "Unclaimed") |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | -what was the activity: multiple, linked age and ability-appropriate activities to record narratives from LINKAGE-Camden participants, culminating in an exhibition-installation representing these embedded within the contents of a "Lost Property Office" -how many people reached: 3,000/week so far. -geographical reach: London and beyond -type of audience engaged with schools, general public etc.: Study members, related community groups and general public. -briefly describe the activity - intended purpose and any outcomes/impacts - see comment and above. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Luigi Ferrucci Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Health professionals |
| Results and Impact | A lecture was organised that sparked questions and discussions afterwards Increased awareness of ageing research, enhanced the relationship with the invited speaker |
| Year(s) Of Engagement Activity | 2014 |
| Description | MRC Festival of Medical Research 2018 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Science Fair in South Cloisters with MRC LMCB and MRC Prion Unit. Our stall used a modified Green Man 2017 "Tangled" |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.nshd.mrc.ac.uk/news-events/recent-news/mrc-festival-2018-blog/ |
| Description | MRC Festival of Medical Research Exhibition 70 years of... |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | The activty showcased the history of the cohorts birthday cards as well as old letters from the study and how data used to be presented. The work was presented in a gallery space in collaboration with an art student from the Univerisyt of the arts as well as the president of the UCL medical and arts society. The idea was to create an art exhibition using historical items from the study |
| Year(s) Of Engagement Activity | 2017 |
| Description | Media interest about Anish N. Bhuva paper about training for a first time marathon |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Significant media coverage of the paper in JACC 'Training for a First-Time Marathon Reverses Age-Related Aortic Stiffening'. Associate Director of LHA was an author on this paper |
| Year(s) Of Engagement Activity | 2020 |
| Description | Media interest in 'Smoking induces early signs of cancer in cheek swabs'. |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Increased awareness of NSHD research |
| Year(s) Of Engagement Activity | 2015 |
| Description | NDA Closing Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | The Unit took part in the NDA Closing Conference and had a stand explaining the findings from the HALCyon Study. Director also gave a presentation The NDA HALCyon research programme: Key findings and implications Diana Kuh MRC Unit for Lifelong Health and Ageing on behalf of the HALCyon study team NDA Final Conference London, 21st October 2013 Chance to disseminate HALCyon findings to health professionals, local community groups and the general public |
| Year(s) Of Engagement Activity | 2013 |
| Description | NDA findings brochure |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | The New Dynamics of Ageing programme which funded the HALCyon programme created a findings document summerising the results of the HALCyon programme which was distributed to their local networks Increased awareness of the HALCyon findings and a life course approach to healthy ageing. Increased awareness of longitudinal studies and the cohorts that were involved in HALCyon |
| Year(s) Of Engagement Activity | 2014 |
| Description | NS interviewed by BBC Breakfast News to discuss the first Early Diagnostic Clinic |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | NS was interviewed by BBC Breakfast News to discuss the first Early Diagnostic Clinic which he created at the National Hospital for Neurology and Neurosurgery. Raised awareness of MND, the new clinic and the importance of early diagnosis |
| Year(s) Of Engagement Activity | 2016 |
| Description | NSHD 70th birthday events and media interest |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | The department organised two birthday events for our study members in London and Manchester. The parties gained significant media attention (print and feature on BBC news). The study member feedback was also very positive and the events were seen as a success. Health Study - why we owe so much to the class of '46, The Observer BBC News at 10, Tuesday 1st March BBC Breakfast short version, Wednesday 2nd March BBC Inside Science, Thursday 3rd March The Naked Scientists, Monday 7th March A video of the London event was created by Dreaming Fish on behalf of the MRC. The NSHD also featured on a number of local BBC radio stations on Wednesday 1st March. BBC Radio Cambridgeshire MRC Network Magazine MRC Life Magazine MRC Sound Cloud https://soundcloud.com/the_mrc/mrc-talks-episode-7 Sunday People http://www.mirror.co.uk/news/uk-news/douglas-babies-who-helped-shape-7634768 http://news.xinhuanet.com/english/2016-03/05/c_135159132.htm Study member interviewed on Radio Stoke 4 March 2016 14:26 |
| Year(s) Of Engagement Activity | 2016 |
| Description | NSHD 70th birthday press coverage |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Media interest in the 70th birthday events for the NSHD and coverage of Helen Pearson's book on UK cohorts - The Life Project Articles and features in/on The Independent, The Sunday Times, The Evening Standard, BBC Breakfast News, BBC News at 10, Inside Science, Local BBC radio stations. |
| Year(s) Of Engagement Activity | 2016 |
| Description | New story on MRC website about Einstein's garden at Green Man Festival |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | News story on the MRC public engagement section of their website detailing the activity we took part in for the Green Man Festival |
| Year(s) Of Engagement Activity | 2017 |
| Description | Open meeting at St John and Elizabeth Hospice with MND patients - talk and Q and A session |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Open meeting at St John and Elizabeth Hospice with MND patients - talk and Q and A session. Information shared about MND. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Presentation at the Danish Society for Psychosocial Medicine |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Director invited to give a presentation at the Danish Society for Psychosocial Medicine. Does the life course approach provide new knowledge and how can we use it? Professor Diana Kuh, MRC Unit for Lifelong Health and Ageing Danish Society for Psychosocial Medicine Copenhagen, November 14th 2013 Promotion of life course approach to healthy ageing |
| Year(s) Of Engagement Activity | 2013 |
| Description | Press interest in Daniel Swerdlow paper |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | press interest in research paper that sued NSHD data about the benefits of statins Increased awareness about the benefit of statins |
| Year(s) Of Engagement Activity | 2014 |
| Description | Press interest in Martin Widschwendter breast cancer paper |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Press interest in research paper about breast cancer Increase awareness of the stuudies findings |
| Year(s) Of Engagement Activity | 2014 |
| Description | Press interest in hormones and socioeconomic conditions paper |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Press interest in article about hormones and socioeconomic conditions. The Telegraph published an article on this. Increased awareness of NSHD research. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Press release about IOE merger |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Press release about the merger of IOE which mention the fact that UCL now houses a number of birth cohorts including the NSHD |
| Year(s) Of Engagement Activity | 2015 |
| Description | Press release about delirium paper |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Press release about a research paper about delirium. Increased awareness about delirium. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Press release about healthy migrant hypothesis |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Press release about the paper - An investigation of the healthy migrant hypothesis: Pre-emigration characteristics of those in the British 1946 birth cohort study. Increased awareness about the NSHD research |
| Year(s) Of Engagement Activity | 2016 |
| Description | Press release about menopause Interlace |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Press release about a piece of research about starting menstrual periods at a young age increases risk of premature and early menopause |
| Year(s) Of Engagement Activity | 2017 |
| Description | Press release and Stand about delirium for 'Say Delirium' week |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Press release about how staff at the Royal Free Hospital are urging fellow staff, patients and carers to 'Say delirium' this week (13 - 19 March), in order to raise awareness of this serious condition. There was a stand in the main reception of the Royal Free to raise awareness of the condition with staff and patients and also to promote the DELPHIC study lead by a LHA researcher. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Public Lecture by Kenneth Rockwood, |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Public lecture by Kenneth Rockwood, Professor of Geriatric Medicine at Dalhousie University titled: Does it matter that dementia is mostly a problem of older people?" |
| Year(s) Of Engagement Activity | 2015 |
| Description | Rewired talk |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | NS took part in Rewired which is an event which aims to raise public awareness of neurological conditions using artistic collaborations and cutting-edge research. |
| Year(s) Of Engagement Activity | 2017 |
| Description | School Visit |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | In March 2022, C.Park played a key role in science week for 'Kings Court First School' in Old Windsor. She led an assembly of 300 4-10 year olds and spoke to them about becoming a scientist. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Talk to Year 10 students from Westminster Academy |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Nik Sharma spoke to a group of year 10's from Westminster Academy as part of the UCLH/Biomedical Research Centre open day. The topic was 'what is research and the career of a researcher' and the talk sparked questions and discussions afterwards. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Ted Talk by Helen Pearson about The Life Project |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Scientists at the Unit contributed to Helen Pearson's book 'The Life Project'. Helen gave a talk featureing the NSHD for TED. It has had 1,649,889 views and has increased the awareness of the NSHD and longitudinal research. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.ted.com/talks/helen_pearson_lessons_from_the_longest_study_on_human_development |
| Description | Took part in Cheltenham Science Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | DK took part in a Cheltenham Science Festival event with a study member and Helen Pearson to talk about the Life Project book and the work of the NSHD. Raised awareness of NSHD research. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Twitter account created for MRC LHA |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | A twitter account was created for MRC LHA to coincide with the 70th birthday events. We have a number of followers and are working to increase this and promote NSHD research on the account. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Two week student visit at MRC LHA (NS) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Two week sixth form visit to the Unit as part of (http://in2scienceuk.org). in2scienceUK is an award winning organisation which gives students from low income backgrounds the opportunity to work alongside STEM scientists, and receive the advice and information they need to progress to University and STEM careers. |
| Year(s) Of Engagement Activity | 2015 |
| Description | UCL Ageing Festival Event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | The Director was part of a discussion panel at a UCL Ageing Festival Event An UCL/International Longevity Centre-UK discussion Working Longer in an Ageing Society Brian Beach (ILC-UK), Prof Diana Kuh (UCL), Ms Jenny Head (UCL), Ms Katherine Wilson, Carers UK Increase awareness of the benefit of using longitudinal studies to study ageing |
| Year(s) Of Engagement Activity | 2013 |
| Description | Updating BMA Growing Up in the UK Report Update |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Diana Kuh contributed to BMA Growing Up in the UK Report Update and made recommendations. Four main recommendations require action beyond individual behaviour, that is at national level, to address the broader social and economic drivers influencing early environments and possible remedial actions. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Vice-Chair on SAPEA International Working Group 'Transforming the Future of Ageing' in support of European Commission's Scientific Advice Mechanism |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Working group discussion and report produced - SAPEA's evidence review report shows that the ageing process needs to be transformed. Europe must tackle the challenges presented by ageing in every generation. SAPEA report for the EU Commission.Transforming the future of ageing. June 27th 2019. (role: vice-Chair). Report cited in Roller-Wirnsberger, R., Lindner, S., Liew, A. et al.(2020). European Collaborative and Interprofessional Capability Framework for Prevention and Management of Frailty-a consensus process supported by the Joint Action for Frailty Prevention (ADVANTAGE) and the European Geriatric Medicine Society (EuGMS), Aging Clin Exp Res (2020) |
| Year(s) Of Engagement Activity | 2020 |
| URL | http://www.sapea.info/topics/ageing |
| Description | Webinar for motor neurone disease week |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Webinar for Motor Neurone Disease week - Nik Sharma and Jan Clarke (MND Specialist Nurse). Suggestions for topics requested from the public. |
| Year(s) Of Engagement Activity | 2015 |
| URL | https://www.uclh.nhs.uk/aboutus/webchat/Pages/AskanexpertMotorNeuroneDisease.aspx |
| Description | Website media interest in 'Childhood socioeconomic position and adult leisure-time physical activity: a systematic review' |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Paper sparked comments on discussion board Increased awareness of NSHD research |
| Year(s) Of Engagement Activity | 2015 |