Enhancing the MRC National Survey of Health and Development as an interdisciplinary life course study of ageing

Lead Research Organisation: University College London

Abstract

The greatest challenge for research on ageing is to ensure that the health and independence of older people keeps apace with their increasing life expectancy. Ageing starts at the beginning of life, and is affected by biological and social processes acting across the whole of life. This programme is concerned with scientific discovery of these processes. We conduct research on the MRC National Survey of Health and Development (NSHD), the oldest of the British birth cohorts. It is unique in having information, from birth to 66 years, on the health and social circumstances of a large representative sample of those born in England, Wales and Scotland in March 1946.
The focus of this programme is on enhancing the NSHD as a national resource by:

Collecting new data on ageing outcomes (www.nshd.mrc.ac.uk)

Undertaking collaborative research to study the factors at different life stages that promote or inhibit healthy ageing (see www.halcyon.ac.uk)

Encouraging the safe and secure use of NSHD resources, including the genetics resource, by the scientific community

Technical Summary

The MRC National Survey of Health and Development (NSHD) is the oldest of the British birth cohorts, and is unique in having data from birth to age 66 years on the health and social circumstances of a representative sample (N=5,362) of those born in England, Wales and Scotland in March 1946 (www.nshd.mrc.ac.uk). Enhancing NSHD is the core programme of the MRC Unit for Lifelong Health and Ageing, and combines a research and a resource function.

The resource function is to curate, enrich and share the NSHD resource, on which all Unit programmes and research collaborations depend. In the last five years, we have completed the 23rd follow-up, a pioneering clinic data collection, with a high response rate, developed data sharing policies and web-based data sharing tools, raised the international and national profile of the study through the NSHD 65th birthday events, and enhanced NSHD through new biomarker and genetic data. A critical mass of biomedical and social scientists undertakes collaborative projects; since 2007, NSHD data has been shared with 211 scientists from 49 research institutions.

The research function is to foster integrative research across the Unit programmes and with external collaborators, and to build capacity in life course epidemiology and ageing research. Ongoing studies include: the lifetime determinants of kidney function, thyroid function, and healthy ageing; the long-term health effects of exposure to air pollution; dietary studies; and genetic studies. Much of this work involves comparative research across cohorts. For example, LHA leads the Healthy Ageing across the Life Course (HALCyon) research programme which brings an interdisciplinary group of researchers to study life course determinants of three aspects of healthy ageing across nine UK cohort studies: physical and cognitive capability, social and psychological wellbeing and underlying biology, including aspects of physiology and genetics. More details can be found on www.halcyon.ac.uk.

The two main research themes for NSHD in the next five years are: (1) healthy ageing and the management of health and health care needs as the cohort grows older, and how these are influenced by earlier life experiences; and (2) the biology of ageing, linking epidemiology and mechanistic science in this cohort study. The latter includes planned metabolomic and epigenomic projects, and a new research collaboration on the ageing lung.
We also plan to extend HALCyon cross cohort research activities, data harmonisation and data sharing through our role in the new ESRC/MRC Cohort Resource Facility and through international collaborations.

Organisations

Publications

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AGS/NIA Delirium Conference Writing Group, Planning Committee And Faculty (2015) The American Geriatrics Society/National Institute on Aging Bedside-to-Bench Conference: Research Agenda on Delirium in Older Adults. in Journal of the American Geriatrics Society

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Allinson JP (2017) Combined Impact of Smoking and Early-Life Exposures on Adult Lung Function Trajectories. in American journal of respiratory and critical care medicine

 
Description All-Party Parliamentary Group on Medical Research (APPG) event on big data
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description CLOSER KEW - Particpant engagement
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact MR gave a talk at the CLOSER knowledge exchange workshop on cohort management. The talk sparked discussion and questions afterwards and the Unit led a round table on cohort management of older people.
 
Description CLOSER Workshop - Cross-cohort research: Opportunities, challenges and examples
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Increased researcher awareness and understanding of the challenges and opportunities related to cross cohort research
 
Description CLOSER Workshops
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Increased awareness and understanding of researchers in the following areas Functioning well in later life: What is the evidence from longitudinal studies?* ** Symposium January 15th 2013 Knowledge Exchange Workshop: Challenges for Data Harmony* ** KEW January 16th 2013 Knowledge Exchange Workshop: Integrating the social and biological* KEW April 12th 2013 Training workshop: Life Course Research* ** Training workshop Monday 17 March 2014 Successful cohort leadership and management* ** Training workshop Friday 16 May 2014
 
Description CLOSER workshop talk in May 2017 - "Adopting new technologies in the MRC National Survey of Health and Development".
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact improved knowledge of researchers
 
Description China-UK Life Science and Medicine Summit
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description GM LHA workshop on Mplus
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
Impact Increased knowledge and skills of attendees inthe field of longitudinal data analysis using the mplus software
 
Description GM Pre conference workshop at Nordic Congress 2014
Geographic Reach Asia 
Policy Influence Type Influenced training of practitioners or researchers
Impact Increased knowledge and skills of attendees in the areas of 'mixture models in the context of replication' and 'change point models in ageing research'
 
Description GM Survival Models Workshop in Uruguay
Geographic Reach South America 
Policy Influence Type Influenced training of practitioners or researchers
Impact Increased knowledge and skills of attendees in the area of Joint survival models
 
Description GM Vancouver workshop
Geographic Reach North America 
Policy Influence Type Influenced training of practitioners or researchers
Impact Pre conference workshop in Vancouver on April 24-26/2014 on Longitudinal Data Analysis using Mplus. The conference is the International Health data Linkage. Increased knowledge and skills of attendees in this area
 
Description GM workshop in SRCD San Diego
Geographic Reach North America 
Policy Influence Type Influenced training of practitioners or researchers
Impact Graciela's workshop in SRCD (San Diego) attended by researchers conducting research in Child development. Increased skills and awareness of attendees in the area of 'Recommended Approaches for Coordinated Analysis and Reproducible Multiple-Study Research'
 
Description Longitudinal data analysis course at UCL
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
Impact Increased awareness and skills of attendees in longitudinal data analysis course. Run at UCL ( jointly with Jenny head, Mai Stafford, Owen Nicholas and Amanda Sacker)
 
Description MRC Unit for Lifelong Health and Ageing Response to PHE request for Strategy Consultation.
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description NICE Menopause Guidelines
Geographic Reach National 
Policy Influence Type Membership of a guidance committee
 
Description Parliamentary Post Note: The Ageing Process and Health
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL http://researchbriefings.parliament.uk/ResearchBriefing/Summary/POST-PN-0571
 
Description Progress report written for 2016 BMA Growing up in the UK report on Life course and developmental origins of adult health and disease
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Round table event was organised to discuss the review
URL https://www.bma.org.uk/collective-voice/policy-and-research/public-and-population-health/child-healt...
 
Description RH expert advisor
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
Impact The guideline aims to improve the consistency of support and information provided to women in menopause.
URL https://www.nice.org.uk/guidance/ng23
 
Description Ran Multilevel modelling course at UCL
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
Impact Too early to say but researchers should be more skilled in multilevel modelling which should help to improve the quality of research being carried out.
 
Description Response to Government consultation: National Data Guardian for Health and Care's Review of Data Security, Consent and Opt-Outs
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description Sucessful cohort leadership and management course
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Our director co-organised a training event about successful cohort leadership and management. We hope this event will lead to more researchers taking an interest in leading a cohort and understanding what it means to manage a cohort on a day to day basis. We hope it will lead to the cohort leaders of the future.
 
Description Talk by AW at CLOSER workshop Working with biological sampes in cohort studies
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Talk by PC at Closer workshop: Methods of disclosure control : Best practive within longitudinal studies
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Written submission to the House of Commons Health Committee inquiry on the impact of physical activity and diet on health.
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description Alzheimers Society Clinical Fellows/UCLH Funding
Amount £150,000 (GBP)
Organisation Alzheimer’s Society 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2018 
End 09/2021
 
Description Alzheimers Society Clinical Fellows/UCLH Funding
Amount £150,000 (GBP)
Organisation University College London Hospitals NHS Foundation Trust 
Sector Public
Country United Kingdom
Start 09/2018 
End 09/2021
 
Description DELPHIC
Amount £980,884 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2016 
End 04/2020
 
Description Lost and Found Public engagement funding
Amount £123,300 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2018 
 
Description MRC Proximity to Discovery
Amount £6,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 06/2017 
End 07/2017
 
Description RB Spanish Ministry of Economy and Competitiveness
Amount € 27,000 (EUR)
Organisation Spanish Ministry of Economy and Competitiveness 
Sector Public
Country Spain
Start  
 
Description Reta Lila Trust Project Grant
Amount £1,191,595 (GBP)
Organisation Reta Lila Weston Trust For Medical Research 
Sector Charity/Non Profit
Country Unknown
Start  
 
Description Springboard Fellowship
Amount £55,000 (GBP)
Organisation University College London 
Sector Academic/University
Country United Kingdom
Start 03/2016 
End 09/2018
 
Description UCL Global Engagement Fund DD
Amount £1,800 (GBP)
Organisation University College London 
Sector Academic/University
Country United Kingdom
Start 03/2017 
End 06/2017
 
Description Wellcome Trust ISSF
Amount £75,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Title Age 68-69 postal questionnaire and home visit 
Description A new postal questionnaire was sent to NSHD study members. A variety of questions were asked about Family, home and retirement Wellbeing Lifestyle/social activities Sleep Illnesses and health problems Recent health checks hospital admissions All willing study members had a home visit during 2015-2016. Various things were measured/taken/completed Blood samples Physical activity Anthropometry Cognition Lung capacity Health behaviours Socioeconomic circumstances Medical review 
Type Of Material Database/Collection of data 
Year Produced 2016 
Provided To Others? Yes  
Impact too early to say data has only just been cleaned 
 
Title HALCyon data sets and meta data 
Description One of the main aims of HALCyon was to perform comparable analyses across 9 British cohort studies which tested the inter-relationships between: physical and cognitive capability; social and psychological wellbeing and; underlying biological markers of ageing. Another main aim was to test the associations of factors across life with each of these three sets of measures. In the majority of cases, this involved harmonising secondary data from the 9 participating studies which had been provided to the HALCyon study team by cohort PIs. For details of how to access the most up to date versions of these secondary data please contact the MRC Unit for Lifelong Health and Ageing at UCL, the relevant cohort leads or where available download these data from UK Data Service ReShare (for ELSA and 1958 birth cohort). The following documentation is freely available via UK Data Service ReShare or the HALCyon data documentation page (1) lists of the comparable variables available in each cohort for topics of relevance to HALCyon; (2) Stata syntax which was used to clean and recode data for use in analyses that were comparable across cohorts. The NDA grant for HALCyon also included funds to - collect comparable data on wellbeing in: Hertfordshire Cohort Study (HCS); Caerphilly Prospective Study (CaPS); Aberdeen Birth Cohort 1936 (ABC1936) See for example: Cooper R et al. AGE 2014;36:445-456 - measure telomere length using existing blood samples in: Lothian Birth Cohort 1921 (LBC1921); CaPS; Hertfordshire Ageing study (HAS); MRC National Survey of Health and Development See for example: Gardner M et al. PLoS One 2013;8(7):e69526 - perform cortisol assays using existing saliva samples in: CaPS and NSHD See for example: Gardner M et al. Psychoneuroendocrinology 2013;38:40-49 - undertake qualitative interviews with HCS and NSHD participants (30 in each study) See for example: The content of the interview topic guide, the sampling strategy and the characteristics of the sample achieved are described in a Centre for Longitudinal Studies working paper (2011/5), by Jane Elliott et al, October 2011 
Type Of Material Database/Collection of data 
Year Produced 2014 
Provided To Others? Yes  
Impact A data request was made for the HALCyon dataset and this was provided 
URL http://www.halcyon.ac.uk/?q=node/366
 
Title Lipodomics and Homocysteine 60-64 
Description Lipodomics and Homocysteine collected at age 60-64. A DOI will be created and the data made available to other researchers 
Type Of Material Database/Collection of data 
Year Produced 2016 
Provided To Others? Yes  
Impact paper submitted by HNR 
 
Title Omics data 
Description omics data completed and available to share with other researchers 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? Yes  
Impact Research papers completed with the data 
 
Description ADH1B-cardiovascular disease collaboration 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution NSHD data sharing (genotyping already completed) Contribute to the scientific development of the project throughout Help with drafting and revision of papers
Collaborator Contribution Analysis and interpretation of data Preparation of manuscripts
Impact Holmes et al PMID: 25011450
Start Year 2012
 
Description Advancing understanding of delirium severity: the contribution of domains of the delirium syndrome to outcomes 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration on research project, grant applications, data analysis, manuscript preparation
Collaborator Contribution Collaboration on research project, grant applications, data analysis, manuscript preparation
Impact NIA-NIDUS award
Start Year 2017
 
Description Ageing Lung consortium 
Organisation Imperial College London
Department Faculty of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution To test (1) whether the social and biological factors operating early in life, and previously found in this cohort to adversely influence adult lung function and respiratory symptoms, also affect decline in lung function with age; (2) whether cumulative exposure to an anti-oxidant rich diet is associated with slower lung function decline; (3) whether these effects are mediated through altered DNA methylation; (4) whether DNA methylation signatures predict which smokers will have accelerated decline; and (5) whether the associations between lung function and mortality, cardiovascular disease and diabetes might be explained by patterns of early growth or later diet, by perturbation of inflammatory/hormonal pathways, or by genes. Longer-term plans: To add a more detailed assessment of lung function and respiratory disease at the next follow-up in order to define COPD and its sub-phenotypes better. NSHD data sharing, analysis, interpretation, drafting and revision of papers
Collaborator Contribution Analysis, interpretation, drafting and revision of papers. At the next data collection, our expert collaborators, will help LHA to characterise lung function and its decline and the development of respiratory disease in greater detail. One collaborator will jointly supervise a new CDF post who will investigate lung function decline.
Impact A grant application has been written and is in the process of being submitted Dunhill Medical Trust grant application invited to full application stage - Seif Shaheen Horsfall et al PMID: 25086287 PMID 26695373
Start Year 2012
 
Description Ageing Lung consortium 
Organisation Medical Research Council (MRC)
Department MRC Human Nutrition Research Unit
Country United Kingdom 
Sector Public 
PI Contribution To test (1) whether the social and biological factors operating early in life, and previously found in this cohort to adversely influence adult lung function and respiratory symptoms, also affect decline in lung function with age; (2) whether cumulative exposure to an anti-oxidant rich diet is associated with slower lung function decline; (3) whether these effects are mediated through altered DNA methylation; (4) whether DNA methylation signatures predict which smokers will have accelerated decline; and (5) whether the associations between lung function and mortality, cardiovascular disease and diabetes might be explained by patterns of early growth or later diet, by perturbation of inflammatory/hormonal pathways, or by genes. Longer-term plans: To add a more detailed assessment of lung function and respiratory disease at the next follow-up in order to define COPD and its sub-phenotypes better. NSHD data sharing, analysis, interpretation, drafting and revision of papers
Collaborator Contribution Analysis, interpretation, drafting and revision of papers. At the next data collection, our expert collaborators, will help LHA to characterise lung function and its decline and the development of respiratory disease in greater detail. One collaborator will jointly supervise a new CDF post who will investigate lung function decline.
Impact A grant application has been written and is in the process of being submitted Dunhill Medical Trust grant application invited to full application stage - Seif Shaheen Horsfall et al PMID: 25086287 PMID 26695373
Start Year 2012
 
Description Ageing Lung consortium 
Organisation Queen Mary University of London
Department Barts and The London School of Medicine and Dentistry
Country United Kingdom 
Sector Academic/University 
PI Contribution To test (1) whether the social and biological factors operating early in life, and previously found in this cohort to adversely influence adult lung function and respiratory symptoms, also affect decline in lung function with age; (2) whether cumulative exposure to an anti-oxidant rich diet is associated with slower lung function decline; (3) whether these effects are mediated through altered DNA methylation; (4) whether DNA methylation signatures predict which smokers will have accelerated decline; and (5) whether the associations between lung function and mortality, cardiovascular disease and diabetes might be explained by patterns of early growth or later diet, by perturbation of inflammatory/hormonal pathways, or by genes. Longer-term plans: To add a more detailed assessment of lung function and respiratory disease at the next follow-up in order to define COPD and its sub-phenotypes better. NSHD data sharing, analysis, interpretation, drafting and revision of papers
Collaborator Contribution Analysis, interpretation, drafting and revision of papers. At the next data collection, our expert collaborators, will help LHA to characterise lung function and its decline and the development of respiratory disease in greater detail. One collaborator will jointly supervise a new CDF post who will investigate lung function decline.
Impact A grant application has been written and is in the process of being submitted Dunhill Medical Trust grant application invited to full application stage - Seif Shaheen Horsfall et al PMID: 25086287 PMID 26695373
Start Year 2012
 
Description Ageing Lung consortium 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution To test (1) whether the social and biological factors operating early in life, and previously found in this cohort to adversely influence adult lung function and respiratory symptoms, also affect decline in lung function with age; (2) whether cumulative exposure to an anti-oxidant rich diet is associated with slower lung function decline; (3) whether these effects are mediated through altered DNA methylation; (4) whether DNA methylation signatures predict which smokers will have accelerated decline; and (5) whether the associations between lung function and mortality, cardiovascular disease and diabetes might be explained by patterns of early growth or later diet, by perturbation of inflammatory/hormonal pathways, or by genes. Longer-term plans: To add a more detailed assessment of lung function and respiratory disease at the next follow-up in order to define COPD and its sub-phenotypes better. NSHD data sharing, analysis, interpretation, drafting and revision of papers
Collaborator Contribution Analysis, interpretation, drafting and revision of papers. At the next data collection, our expert collaborators, will help LHA to characterise lung function and its decline and the development of respiratory disease in greater detail. One collaborator will jointly supervise a new CDF post who will investigate lung function decline.
Impact A grant application has been written and is in the process of being submitted Dunhill Medical Trust grant application invited to full application stage - Seif Shaheen Horsfall et al PMID: 25086287 PMID 26695373
Start Year 2012
 
Description Ageing Lung consortium 
Organisation University of Southampton
Country United Kingdom 
Sector Academic/University 
PI Contribution To test (1) whether the social and biological factors operating early in life, and previously found in this cohort to adversely influence adult lung function and respiratory symptoms, also affect decline in lung function with age; (2) whether cumulative exposure to an anti-oxidant rich diet is associated with slower lung function decline; (3) whether these effects are mediated through altered DNA methylation; (4) whether DNA methylation signatures predict which smokers will have accelerated decline; and (5) whether the associations between lung function and mortality, cardiovascular disease and diabetes might be explained by patterns of early growth or later diet, by perturbation of inflammatory/hormonal pathways, or by genes. Longer-term plans: To add a more detailed assessment of lung function and respiratory disease at the next follow-up in order to define COPD and its sub-phenotypes better. NSHD data sharing, analysis, interpretation, drafting and revision of papers
Collaborator Contribution Analysis, interpretation, drafting and revision of papers. At the next data collection, our expert collaborators, will help LHA to characterise lung function and its decline and the development of respiratory disease in greater detail. One collaborator will jointly supervise a new CDF post who will investigate lung function decline.
Impact A grant application has been written and is in the process of being submitted Dunhill Medical Trust grant application invited to full application stage - Seif Shaheen Horsfall et al PMID: 25086287 PMID 26695373
Start Year 2012
 
Description BRC collaboration with IoN 
Organisation University College London
Department Institute of Neurology
Country United Kingdom 
Sector Academic/University 
PI Contribution Our Clincial Consultant is part of a UCL bid for BRC application under the 'big questions scheme'. (http://www.uclhospitals.brc.nihr.ac.uk/news/%C2%A31m-available-brc-neurosciences-research) Linda Greensmith is leading the application. Part of the study will MRI of muscles (as a biomarker) and hopefully MRI brain. The clinical fellow has a track record for brain imaging research and will build on proposed project to develop CNS imaging in ALS. Will contribute to patient recruitment. Use structural brain imaging to identify BA4p - recently shown to be the origin of corticomotoneuron connections. We will explore the relationship between changes within the motor cortex and distal changes documented by the muscle MRI and biomarkers. The use biomarkers and muscle MRI would in of select study members in the future as healthy volunteers will allow a more detailed and richer understanding of these biomarkers in the context of the life-course and will benefit from the detailed longitudinal data on muscle characteristics already available. We may provide NSHD study members to take part in this study Contributions will include data analysis, research advice, publication writing, grant applications, editing manuscripts and knowledge exchange
Collaborator Contribution Contributions will include data analysis, research advice, publication writing, grant applications, editing manuscripts and knowledge exchange
Impact Grant application funded
Start Year 2014
 
Description Biomarkers of Ageing 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution We have shared NSHD DNA data and LHA scientists are leading and contributing to scientific outputs
Collaborator Contribution LHA scientists are gaining knowledge about telomeres and other markers of biological ageing
Impact Enriching the NSHD with new data on telomeres. Scientific outputs are forthcoming I have extended the collaboration between LHA and the Institute of Ageing by asking Professor Thomas Zyglinicki to be a work package leader on a telomere study across a number of cohorts as part of the HALCyon research programme on which I am the PI. Baylis et al PMID:24858709 Martin-Ruiz et al PMID: 25239152 PMID 26403813 PMID 26403811 PMID 25239152
Start Year 2007
 
Description CAPA 
Organisation Alzheimer's Drug Discovery Foundation
Country United States 
Sector Charity/Non Profit 
PI Contribution The ADDF created the Cohorts for Alzheimer's Prevention Action (CAPA) Consortium to strengthen the evidence for potential preventative treatments. This program will fund specific analyses across a minimum of 5 longitudinal cohorts to examine the association of actionable interventions with the risk of cognitive aging, Alzheimer's disease, related dementias, or biomarkers related to brain aging and neurodegeneration. NSHD will apply for specific funding to use NSHD data to help find interventions in relation to Alzheimer's disease, related dementias, or biomarkers related to brain aging and neurodegeneration.
Collaborator Contribution Funding will be provided
Impact We have only just joined this consortium so are looking at ways to become involved
Start Year 2014
 
Description CARTA 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution The consortium for Causal Analysis for Research in Tobacco and Alcohol (CARTA), currently comprising 23 studies and over 50,000 individuals, has been created to examine the causal impact of cigarette smoking on a number of outcomes, including depression, anxiety, cardiovascular and metabolic measures, allergy, regional adiposity, socioeconomic status, and a host of other phenotypes. The Unit will share NSHD data, help with data analysis, writing publciations, editing manuscripts and contributing to grant applications.
Collaborator Contribution Data analysis, writing publciations, editing manuscripts and contributing to grant applciations.
Impact Grant application about to be submitted. Taylor PMID: 25293386 Linneberg PMID:26538566 Morris PMID:26264275 Skaaby T.Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium. PMID: 28533558 PMC5440386
Start Year 2012
 
Description CLOSER 
Organisation University College London
Department Institute of Education (IOE)
Country United Kingdom 
Sector Academic/University 
PI Contribution Leading on work packages and the teaching aspect of CLOSER. This includes data analysis, preparing and commenting on manuscripts, organising workshops, seminars and conferences. Members of the executive group and CLOSER communications network.
Collaborator Contribution CLOSER (Cohort & Longitudinal Studies Enhancement Resources) aims to maximise their use, value and impact both at home and abroad. Bringing together eight leading studies, the British Library and the UK Data Service, CLOSER works to stimulate interdisciplinary research, develop shared resources, provide training, and share expertise. In this way CLOSER is helping to build the body of knowledge on how life in the UK is changing - both across generations and in comparison to the rest of the world.
Impact Johnson 2017 PMID:28072856 Bann 2017 PMID: 28072856 2 successful bids to the innovation fund
Start Year 2012
 
Description CLOSER innovation Bid - Andy Boyd 
Organisation Bradford Institute for Health Research (BIHR)
Department Born in Bradford
Country United Kingdom 
Sector Public 
PI Contribution • establishing an expert working group, comprising studies who have extracted EPRs and those with active plans to do so; • developing, with industry partners, a standard specification for data extracts which is optimised for efficiency, transparency and ability to deliver comparable results; • identifying critical data quality and interoperability issues; and devising recommendations as to how to deal with these; • working with key industry and research infrastructure partners to gain insights, to develop networks and to advocate for longitudinal studies use of EPRs; • considering approaches for harmonising EPR information to support cross-cohort comparison studies; • identifying training/capacity needs and gaps in provision; • working with key industry and health sector partners to consider the impact on longitudinal studies of planned and future changes in health care informatics (e.g. patient access to their own health care EPRs); • writing a position paper summarising our findings and hosting a knowledge exchange workshop to disseminate our findings. This application seeks support for a series of workshops and resource to write the position paper. The programme focuses on data science issues rather than governance issues.
Collaborator Contribution • establishing an expert working group, comprising studies who have extracted EPRs and those with active plans to do so; • developing, with industry partners, a standard specification for data extracts which is optimised for efficiency, transparency and ability to deliver comparable results; • identifying critical data quality and interoperability issues; and devising recommendations as to how to deal with these; • working with key industry and research infrastructure partners to gain insights, to develop networks and to advocate for longitudinal studies use of EPRs; • considering approaches for harmonising EPR information to support cross-cohort comparison studies; • identifying training/capacity needs and gaps in provision; • working with key industry and health sector partners to consider the impact on longitudinal studies of planned and future changes in health care informatics (e.g. patient access to their own health care EPRs); • writing a position paper summarising our findings and hosting a knowledge exchange workshop to disseminate our findings. This application seeks support for a series of workshops and resource to write the position paper. The programme focuses on data science issues rather than governance issues.
Impact One workshop held
Start Year 2017
 
Description CLOSER innovation Bid - Andy Boyd 
Organisation Millennium Cohort Study (MCS)
Country United Kingdom 
Sector Public 
PI Contribution • establishing an expert working group, comprising studies who have extracted EPRs and those with active plans to do so; • developing, with industry partners, a standard specification for data extracts which is optimised for efficiency, transparency and ability to deliver comparable results; • identifying critical data quality and interoperability issues; and devising recommendations as to how to deal with these; • working with key industry and research infrastructure partners to gain insights, to develop networks and to advocate for longitudinal studies use of EPRs; • considering approaches for harmonising EPR information to support cross-cohort comparison studies; • identifying training/capacity needs and gaps in provision; • working with key industry and health sector partners to consider the impact on longitudinal studies of planned and future changes in health care informatics (e.g. patient access to their own health care EPRs); • writing a position paper summarising our findings and hosting a knowledge exchange workshop to disseminate our findings. This application seeks support for a series of workshops and resource to write the position paper. The programme focuses on data science issues rather than governance issues.
Collaborator Contribution • establishing an expert working group, comprising studies who have extracted EPRs and those with active plans to do so; • developing, with industry partners, a standard specification for data extracts which is optimised for efficiency, transparency and ability to deliver comparable results; • identifying critical data quality and interoperability issues; and devising recommendations as to how to deal with these; • working with key industry and research infrastructure partners to gain insights, to develop networks and to advocate for longitudinal studies use of EPRs; • considering approaches for harmonising EPR information to support cross-cohort comparison studies; • identifying training/capacity needs and gaps in provision; • working with key industry and health sector partners to consider the impact on longitudinal studies of planned and future changes in health care informatics (e.g. patient access to their own health care EPRs); • writing a position paper summarising our findings and hosting a knowledge exchange workshop to disseminate our findings. This application seeks support for a series of workshops and resource to write the position paper. The programme focuses on data science issues rather than governance issues.
Impact One workshop held
Start Year 2017
 
Description CLOSER innovation Bid - Andy Boyd 
Organisation UK Biobank
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution • establishing an expert working group, comprising studies who have extracted EPRs and those with active plans to do so; • developing, with industry partners, a standard specification for data extracts which is optimised for efficiency, transparency and ability to deliver comparable results; • identifying critical data quality and interoperability issues; and devising recommendations as to how to deal with these; • working with key industry and research infrastructure partners to gain insights, to develop networks and to advocate for longitudinal studies use of EPRs; • considering approaches for harmonising EPR information to support cross-cohort comparison studies; • identifying training/capacity needs and gaps in provision; • working with key industry and health sector partners to consider the impact on longitudinal studies of planned and future changes in health care informatics (e.g. patient access to their own health care EPRs); • writing a position paper summarising our findings and hosting a knowledge exchange workshop to disseminate our findings. This application seeks support for a series of workshops and resource to write the position paper. The programme focuses on data science issues rather than governance issues.
Collaborator Contribution • establishing an expert working group, comprising studies who have extracted EPRs and those with active plans to do so; • developing, with industry partners, a standard specification for data extracts which is optimised for efficiency, transparency and ability to deliver comparable results; • identifying critical data quality and interoperability issues; and devising recommendations as to how to deal with these; • working with key industry and research infrastructure partners to gain insights, to develop networks and to advocate for longitudinal studies use of EPRs; • considering approaches for harmonising EPR information to support cross-cohort comparison studies; • identifying training/capacity needs and gaps in provision; • working with key industry and health sector partners to consider the impact on longitudinal studies of planned and future changes in health care informatics (e.g. patient access to their own health care EPRs); • writing a position paper summarising our findings and hosting a knowledge exchange workshop to disseminate our findings. This application seeks support for a series of workshops and resource to write the position paper. The programme focuses on data science issues rather than governance issues.
Impact One workshop held
Start Year 2017
 
Description CLOSER innovation Bid - Andy Boyd 
Organisation University of Bristol
Department Avon Longitudinal Study of Parents and Children (ALSPAC)
Country United Kingdom 
Sector Academic/University 
PI Contribution • establishing an expert working group, comprising studies who have extracted EPRs and those with active plans to do so; • developing, with industry partners, a standard specification for data extracts which is optimised for efficiency, transparency and ability to deliver comparable results; • identifying critical data quality and interoperability issues; and devising recommendations as to how to deal with these; • working with key industry and research infrastructure partners to gain insights, to develop networks and to advocate for longitudinal studies use of EPRs; • considering approaches for harmonising EPR information to support cross-cohort comparison studies; • identifying training/capacity needs and gaps in provision; • working with key industry and health sector partners to consider the impact on longitudinal studies of planned and future changes in health care informatics (e.g. patient access to their own health care EPRs); • writing a position paper summarising our findings and hosting a knowledge exchange workshop to disseminate our findings. This application seeks support for a series of workshops and resource to write the position paper. The programme focuses on data science issues rather than governance issues.
Collaborator Contribution • establishing an expert working group, comprising studies who have extracted EPRs and those with active plans to do so; • developing, with industry partners, a standard specification for data extracts which is optimised for efficiency, transparency and ability to deliver comparable results; • identifying critical data quality and interoperability issues; and devising recommendations as to how to deal with these; • working with key industry and research infrastructure partners to gain insights, to develop networks and to advocate for longitudinal studies use of EPRs; • considering approaches for harmonising EPR information to support cross-cohort comparison studies; • identifying training/capacity needs and gaps in provision; • working with key industry and health sector partners to consider the impact on longitudinal studies of planned and future changes in health care informatics (e.g. patient access to their own health care EPRs); • writing a position paper summarising our findings and hosting a knowledge exchange workshop to disseminate our findings. This application seeks support for a series of workshops and resource to write the position paper. The programme focuses on data science issues rather than governance issues.
Impact One workshop held
Start Year 2017
 
Description Calibration Study/University of Southampton 
Organisation Economic and Social Research Council
Country United Kingdom 
Sector Public 
PI Contribution The NSHD has carried out a calibration study of spirometers and blood pressure monitors used in various cohort studies. NSHD staff have carried out these assessments and are coordinating the project.
Collaborator Contribution The funding for this project was provided by the CLOSER research programme innovation fund through the ESRC. A PhD student enrolled at University of Southampton working with TNS/MDG has helped to coordinator the project and carry out the assessments. They will be writing up the results as part of their PhD.
Impact All the volunteers have been seen Researcher has registered for a PhD Oral presentation at European Survey Research Association, Lisbon July 2017
Start Year 2015
 
Description Calibration Study/University of Southampton 
Organisation University of Southampton
Country United Kingdom 
Sector Academic/University 
PI Contribution The NSHD has carried out a calibration study of spirometers and blood pressure monitors used in various cohort studies. NSHD staff have carried out these assessments and are coordinating the project.
Collaborator Contribution The funding for this project was provided by the CLOSER research programme innovation fund through the ESRC. A PhD student enrolled at University of Southampton working with TNS/MDG has helped to coordinator the project and carry out the assessments. They will be writing up the results as part of their PhD.
Impact All the volunteers have been seen Researcher has registered for a PhD Oral presentation at European Survey Research Association, Lisbon July 2017
Start Year 2015
 
Description Cognitive training to prevent cognitive impairment after cardiovascular surgeries in older adults 
Organisation University of South Australia
Country Australia 
Sector Academic/University 
PI Contribution Data analysis, advice, collaboration on manuscripts. Co-supervisory panel for 2 PhD students
Collaborator Contribution Data analysis, advice, collaboration on manuscripts. Joint grant to provide funding for PhD students
Impact Funding from Heart Foundation (Australia). DD Co-I, on supervisory panel for 2 PhD students
Start Year 2017
 
Description Collaboration on life course theory and methods 
Organisation King's College London
Department Institute of Psychiatry, Psychology & Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution Scientific leads on study design and drafting manuscripts vary, often involves data sharing, always analysis, interpretation and revision of manuscripts
Collaborator Contribution co-editing book on life course methodscollaboration on statistical life course methodscollaboration on statistical life course theory and methodsjoint drafting and revising manuscripts
Impact methods book and chapters 16306313 De Stavola et al AJE 2006 19028777 Mishra GD, Ben-Shlomo Y, Kuh D (in press) Life course approach to health behaviors: theory and methods. In Eds A. Steptoe et al. Handbook of Behavioral Medicine: Methods and Applications. Springer Power and Kuh 2006 Life course development of unequal health. In J Siegrist, M Marmot (Eds) Socioeconomic position and health: new explanations and their policy implications. Oxford University Press SMILE II grant application was not funded Ben Shlomo IJE review PMID: 27880685 Tilling PMID:27880690 Use and misuse of life course methods Howe PMID: 27681097 Mediation analysis and structured life course approach Smith PMID: 27371628 A structure approach to hypotheses
Start Year 2006
 
Description Collaboration on life course theory and methods 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Scientific leads on study design and drafting manuscripts vary, often involves data sharing, always analysis, interpretation and revision of manuscripts
Collaborator Contribution co-editing book on life course methodscollaboration on statistical life course methodscollaboration on statistical life course theory and methodsjoint drafting and revising manuscripts
Impact methods book and chapters 16306313 De Stavola et al AJE 2006 19028777 Mishra GD, Ben-Shlomo Y, Kuh D (in press) Life course approach to health behaviors: theory and methods. In Eds A. Steptoe et al. Handbook of Behavioral Medicine: Methods and Applications. Springer Power and Kuh 2006 Life course development of unequal health. In J Siegrist, M Marmot (Eds) Socioeconomic position and health: new explanations and their policy implications. Oxford University Press SMILE II grant application was not funded Ben Shlomo IJE review PMID: 27880685 Tilling PMID:27880690 Use and misuse of life course methods Howe PMID: 27681097 Mediation analysis and structured life course approach Smith PMID: 27371628 A structure approach to hypotheses
Start Year 2006
 
Description Collaboration on life course theory and methods 
Organisation University College London
Department Institute of Child Health
Country United Kingdom 
Sector Academic/University 
PI Contribution Scientific leads on study design and drafting manuscripts vary, often involves data sharing, always analysis, interpretation and revision of manuscripts
Collaborator Contribution co-editing book on life course methodscollaboration on statistical life course methodscollaboration on statistical life course theory and methodsjoint drafting and revising manuscripts
Impact methods book and chapters 16306313 De Stavola et al AJE 2006 19028777 Mishra GD, Ben-Shlomo Y, Kuh D (in press) Life course approach to health behaviors: theory and methods. In Eds A. Steptoe et al. Handbook of Behavioral Medicine: Methods and Applications. Springer Power and Kuh 2006 Life course development of unequal health. In J Siegrist, M Marmot (Eds) Socioeconomic position and health: new explanations and their policy implications. Oxford University Press SMILE II grant application was not funded Ben Shlomo IJE review PMID: 27880685 Tilling PMID:27880690 Use and misuse of life course methods Howe PMID: 27681097 Mediation analysis and structured life course approach Smith PMID: 27371628 A structure approach to hypotheses
Start Year 2006
 
Description Collaboration on life course theory and methods 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Scientific leads on study design and drafting manuscripts vary, often involves data sharing, always analysis, interpretation and revision of manuscripts
Collaborator Contribution co-editing book on life course methodscollaboration on statistical life course methodscollaboration on statistical life course theory and methodsjoint drafting and revising manuscripts
Impact methods book and chapters 16306313 De Stavola et al AJE 2006 19028777 Mishra GD, Ben-Shlomo Y, Kuh D (in press) Life course approach to health behaviors: theory and methods. In Eds A. Steptoe et al. Handbook of Behavioral Medicine: Methods and Applications. Springer Power and Kuh 2006 Life course development of unequal health. In J Siegrist, M Marmot (Eds) Socioeconomic position and health: new explanations and their policy implications. Oxford University Press SMILE II grant application was not funded Ben Shlomo IJE review PMID: 27880685 Tilling PMID:27880690 Use and misuse of life course methods Howe PMID: 27681097 Mediation analysis and structured life course approach Smith PMID: 27371628 A structure approach to hypotheses
Start Year 2006
 
Description Collaboration on life course theory and methods 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution Scientific leads on study design and drafting manuscripts vary, often involves data sharing, always analysis, interpretation and revision of manuscripts
Collaborator Contribution co-editing book on life course methodscollaboration on statistical life course methodscollaboration on statistical life course theory and methodsjoint drafting and revising manuscripts
Impact methods book and chapters 16306313 De Stavola et al AJE 2006 19028777 Mishra GD, Ben-Shlomo Y, Kuh D (in press) Life course approach to health behaviors: theory and methods. In Eds A. Steptoe et al. Handbook of Behavioral Medicine: Methods and Applications. Springer Power and Kuh 2006 Life course development of unequal health. In J Siegrist, M Marmot (Eds) Socioeconomic position and health: new explanations and their policy implications. Oxford University Press SMILE II grant application was not funded Ben Shlomo IJE review PMID: 27880685 Tilling PMID:27880690 Use and misuse of life course methods Howe PMID: 27681097 Mediation analysis and structured life course approach Smith PMID: 27371628 A structure approach to hypotheses
Start Year 2006
 
Description Collaboration with Bristol Abigail Frazer 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Mentor to fellowship recipient Contributions will include research advice, editing manuscripts and knowledge exchange
Collaborator Contribution Contributions will include data analysis, research advice, publication writing, grant applications, editing manuscripts and knowledge exchange
Impact MRC Fellowship awarded
Start Year 2014
 
Description Collaboration with NHNN, Queen Sqaure 
Organisation National Hospital for Neurology and Neurosurgery
Country United Kingdom 
Sector Hospitals 
PI Contribution Provide expertise, analysis,clinical advice, contribution to research papers and other research activities
Collaborator Contribution Provide expertise, analysis, contribution to research papers and other research activities
Impact MNDA care centre grant (approx 170k)
Start Year 2015
 
Description Collaboration with National Cancer Institute, NIH 
Organisation National Cancer Institute (NCI)
Country United States 
Sector Public 
PI Contribution Data analysis, expertise, contributing to research papers
Collaborator Contribution Data analysis, expertise, contributing to research papers
Impact PMID 26930450 Zhou
Start Year 2015
 
Description Collaboration with Queens Square - Polio 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Contributions will include providing data, data analysis, research advice, publication writing, grant applications, editing manuscripts and knowledge exchange
Collaborator Contribution Contributions will include data analysis, research advice, publication writing, grant applications, editing manuscripts and knowledge exchange
Impact Grant submitted to Medical Research Foundation
Start Year 2014
 
Description Collaboration with Southamption - Nutrition 
Organisation University of Southampton
Department MRC Lifecourse Epidemiology Unit
Country United Kingdom 
Sector Public 
PI Contribution Contributions will include providing data, data analysis, research advice, publication writing, grant applications, editing manuscripts and knowledge exchange
Collaborator Contribution Contributions will include data analysis, research advice, publication writing, grant applications, editing manuscripts and knowledge exchange
Impact Leo Westbury and Sian Robinson are working with us on this Abstracts submitted Paper submitted Robinson et al Paper submitted Westbury et al Muscle paper planned Presentation at SSM and Rank Prize Funds Mini-Symposium Robinson SM Adult lifetime diet quality and physical performance in older age: findings from a British birth cohort. J Gerontol A Biol Sci Med Sci. 2017 Oct 13. PMID: 29040508
Start Year 2013
 
Description Collaboration with TC Institute of Child Health 
Organisation University College London
Department Institute of Child Health
Country United Kingdom 
Sector Academic/University 
PI Contribution We are collaborating on a recently obtained grant developing and applying the SITAR method of growth curve analysis for translational exposures and life course outcomes in human growth assessment. We initially plan to relate the derived parameters to genetic obesity-risk-allele scores and subsequently to health outcomes. Providing NSHD data and expertise
Collaborator Contribution Data analysis, interpretation, drafting and revision of papers. Providing methodological expertise.
Impact Funding for grant application - Developing and applying the SITAR method of growth curve analysis for translational exposures and life course outcomes in human growth assessment. Cole: PMID:27466311 Using SITAR to relate pubertal growth to bone health in later life: the MRC National Survey of Health and Development Kuh: PMID: 27401728 Puberty and bone paper. Variables derived as part of this collaboration are still being used in analysis
Start Year 2012
 
Description Collaboration with Toronto University 
Organisation University of Toronto
Country Canada 
Sector Academic/University 
PI Contribution Contributions will include providing data, data analysis, research advice, publication writing, grant applications, editing manuscripts and knowledge exchange
Collaborator Contribution Contributions will include data analysis, research advice, publication writing, grant applications, editing manuscripts and knowledge exchange
Impact Fuller Thompson et al PMID: 24074458 The healthy migrant effect may confound the link between bilingualism and delayed onset of Alzheimer's disease. PMID: 26986911 An investigation of the healthy migrant hypothesis: Pre-emigration characteristics of those in the British 1946 Birth Cohort study' Canadian Journal of Public Health
Start Year 2013
 
Description Collaboration with UCL Department of Statistical Science 
Organisation University College London
Department Department of Statistical Science
Country United Kingdom 
Sector Academic/University 
PI Contribution One of our new Programme Leader Tracks collaborates with another researcher in the Department of Statistical Science. The CDF used to work with this PI at Cambridge and this collaboration has continued since moving to the Unit. Contributions include data analysis, publication writing, grant applications and editing manuscripts.
Collaborator Contribution Contributions include data analysis, publication writing, grant applications and editing manuscripts.
Impact Grant application 'Optimal design parameters for individual change point models in dementia and ageing research' submitted Publications 23471297 23276221 23136147 PI on grant submitted. Optimal design parameters for individual change point models in dementia and ageing research. Submitted to MRC methodology Board. Co-Pi on grant not funded after first attempt. Analysing cognitive function in the older population: joint latent class models for change and survival. Submitted to MRC methodology board
Start Year 2013
 
Description Collaborations on genetics NES 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution NSHD data sharing, analysis, interpretation, drafting and revision of papers
Collaborator Contribution Prof Aroon Hingorani Expertise in genetics of respiratory functionexpertise in genetics and respiratory function Dallas Swallow provides expertise from UCL Research Department of Genetics, Evolution and Environment
Impact 19254294 Black et al 16759176 Rousseau et al 23551418 Johnson et al 25086287 Horsfall et al
Start Year 2006
 
Description Collaborations on genetics NES 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution NSHD data sharing, analysis, interpretation, drafting and revision of papers
Collaborator Contribution Prof Aroon Hingorani Expertise in genetics of respiratory functionexpertise in genetics and respiratory function Dallas Swallow provides expertise from UCL Research Department of Genetics, Evolution and Environment
Impact 19254294 Black et al 16759176 Rousseau et al 23551418 Johnson et al 25086287 Horsfall et al
Start Year 2006
 
Description Collaborations on genetics NES 
Organisation University of Southampton
Country United Kingdom 
Sector Academic/University 
PI Contribution NSHD data sharing, analysis, interpretation, drafting and revision of papers
Collaborator Contribution Prof Aroon Hingorani Expertise in genetics of respiratory functionexpertise in genetics and respiratory function Dallas Swallow provides expertise from UCL Research Department of Genetics, Evolution and Environment
Impact 19254294 Black et al 16759176 Rousseau et al 23551418 Johnson et al 25086287 Horsfall et al
Start Year 2006
 
Description Describing habitual levels of physical activity LLHW Bristol Collaboration 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Contribtion to grant application ' Describing habitual levels of physical activity in older people in terms of impact loads and how this relates to bone and other systems' that was funded by LLHW
Collaborator Contribution Contribtion to grant application ' Describing habitual levels of physical activity in older people in terms of impact loads and how this relates to bone and other systems' that was funded by LLHW
Impact Grant application awarded in 2013 Protocols have been drafted (2014) Data collection will be incorporated in to 2015 NSHD home visit Around 800 NSHD study members have worn an accelerometer and 1900 have completed an activity questionnaire; these data are comparable to those collected in 3 other studies participating in VIBE. Hannan PMID:27798733 Gaysin T. Physical activity producing low, but not medium or higher, vertical impacts is inversely related to BMI in older adults: findings from a multi cohort study. PMID:29028919 Elhakeem A. Associations of lifetime walking and weight bearing exercise with high impact physical activity in later life. PMID: 29134173 PMC5671612 Elhakeem A. Correlates of high impact physical activity measured objectively in older British adults. PMID: 29237047
Start Year 2012
 
Description Endocrine Senescence collaboration 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution (1) To relate IGF-1 and testosterone, cross-sectionally and longitudinally, to measures of bone and muscle mass, osteoporosis and sarcopenia, and physical and cognitive performance, and (2) to assess whether these hormones are stronger predictors of these ageing outcomes when used together, or in combination with measures of cortisol regulation and thyroid function. Longer-term plans: To undertake a cross cohort study to examine the role of IGF-1 for maintaining healthy trajectories of physical capability. NSHD data sharing, analysis, interpretation, drafting and revision of papers
Collaborator Contribution Writing grant applications, joint scientific leads on study design and drafting manuscripts, student supervision analysis, interpretation and revision of manuscripts.
Impact A grant application was written for this collaboration. Numerous biological assays including IGF have been funded and will be completed by our collaborators by March 2013. A CDF post starting in January 2013 will be jointly supervised by one of these collaborators. Two papers are in progress Two papers have been revised and resubmitted - Testosterone and body composition and IGF and obesity PMID 25645314,25875330,26053924,26588434
Start Year 2012
 
Description Endocrine Senescence collaboration 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution (1) To relate IGF-1 and testosterone, cross-sectionally and longitudinally, to measures of bone and muscle mass, osteoporosis and sarcopenia, and physical and cognitive performance, and (2) to assess whether these hormones are stronger predictors of these ageing outcomes when used together, or in combination with measures of cortisol regulation and thyroid function. Longer-term plans: To undertake a cross cohort study to examine the role of IGF-1 for maintaining healthy trajectories of physical capability. NSHD data sharing, analysis, interpretation, drafting and revision of papers
Collaborator Contribution Writing grant applications, joint scientific leads on study design and drafting manuscripts, student supervision analysis, interpretation and revision of manuscripts.
Impact A grant application was written for this collaboration. Numerous biological assays including IGF have been funded and will be completed by our collaborators by March 2013. A CDF post starting in January 2013 will be jointly supervised by one of these collaborators. Two papers are in progress Two papers have been revised and resubmitted - Testosterone and body composition and IGF and obesity PMID 25645314,25875330,26053924,26588434
Start Year 2012
 
Description Endocrine Senescence collaboration 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution (1) To relate IGF-1 and testosterone, cross-sectionally and longitudinally, to measures of bone and muscle mass, osteoporosis and sarcopenia, and physical and cognitive performance, and (2) to assess whether these hormones are stronger predictors of these ageing outcomes when used together, or in combination with measures of cortisol regulation and thyroid function. Longer-term plans: To undertake a cross cohort study to examine the role of IGF-1 for maintaining healthy trajectories of physical capability. NSHD data sharing, analysis, interpretation, drafting and revision of papers
Collaborator Contribution Writing grant applications, joint scientific leads on study design and drafting manuscripts, student supervision analysis, interpretation and revision of manuscripts.
Impact A grant application was written for this collaboration. Numerous biological assays including IGF have been funded and will be completed by our collaborators by March 2013. A CDF post starting in January 2013 will be jointly supervised by one of these collaborators. Two papers are in progress Two papers have been revised and resubmitted - Testosterone and body composition and IGF and obesity PMID 25645314,25875330,26053924,26588434
Start Year 2012
 
Description Endocrine Senescence collaboration 
Organisation University of Southampton
Department MRC Lifecourse Epidemiology Unit
Country United Kingdom 
Sector Public 
PI Contribution (1) To relate IGF-1 and testosterone, cross-sectionally and longitudinally, to measures of bone and muscle mass, osteoporosis and sarcopenia, and physical and cognitive performance, and (2) to assess whether these hormones are stronger predictors of these ageing outcomes when used together, or in combination with measures of cortisol regulation and thyroid function. Longer-term plans: To undertake a cross cohort study to examine the role of IGF-1 for maintaining healthy trajectories of physical capability. NSHD data sharing, analysis, interpretation, drafting and revision of papers
Collaborator Contribution Writing grant applications, joint scientific leads on study design and drafting manuscripts, student supervision analysis, interpretation and revision of manuscripts.
Impact A grant application was written for this collaboration. Numerous biological assays including IGF have been funded and will be completed by our collaborators by March 2013. A CDF post starting in January 2013 will be jointly supervised by one of these collaborators. Two papers are in progress Two papers have been revised and resubmitted - Testosterone and body composition and IGF and obesity PMID 25645314,25875330,26053924,26588434
Start Year 2012
 
Description Epigenetics Kings 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Epigenetics response to social and environmental cues in early life and over the life course: impact on health ageing in UK population-based cohorts. Contribution of NSHD data, analysis, writing papers
Collaborator Contribution Epigenetics response to social and environmental cues in early life and over the life course: impact on health ageing in UK population-based cohorts. Contribution of other population based data, analysis, writing papers
Impact New staff appointment 2 abstracts - WT epigenomics of common disease and and IEA World Congress Maddock. Impact of body size, nutrition and socioeconomic position in early life on the epigenome: A systematic review protocol. PMID:
Start Year 2016
 
Description Healthy Ageing Across the Life course (HALCyon) 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Diana Kuh is the PI of this interdisciplinary collaboration of scientists investigating the life course determinants of healthy ageing in 9 UK cohort studies. Rebecca Hardy leads the methodological core and the capability work package. Marcus Richards leads the knowledge transfer component and co-leads the nutritional work package. Gita Mishra is a member of the nutritional and wellbeing work packages. 2 postdoctoral scientists are HALCyon-funded.
Collaborator Contribution Yoav Ben-Shlomo in Bristol leads on the biology of ageing work packages for HALCyon, provides cohort data.Prof Thomas Zyglinivki leads the corss cohort HALCyon work package on telomeresProf Avan Aihie Sayer contributes to the HALCyon capability work package. Dr Catherine Gale leads the HALCyon wellbeing work package. Prof Cyrus Cooper is a co-investigator. Provide cohort data.HALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorCo-lead of HALCyon nutrition work packageHALCyon co-investigator for geocodingHALCyon co-investigator provides Lothian cohort dataHALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorExpertise in geriatric medicine and frailtyExpertise on ageing
Impact Several workshops and publications. Symposium - April 2010 Conference - Nov 2010 Conference- June 2012 Workshop - September 2012 Numerous published papers have used the data from other cohorts and other researcher have contributed to the production of these research papers. Data sent to external scientists 2016 21542061 21332924 21297868 22114723 20843964 22253814 23072920 22970320 22923606 22658392 22326597 22209408 21349224 21764771 21737047 21860018 20829298 20843964 19864640 23108707 21225350 22415954 21416275 22923606 17634317 20214846 23468552 23072920 23894584 23818103 22658392 23922731 23437142 Kuh et al: A life course approach to physical capability: findings from the HALCyon research programme. Bode and Scheidt-Nave (eds): European Workshop on Health and Disability Surveillance in Ageing Populations (EUWAP). BMC Proceedings 2013, Volume 7, Supplement 4:S4 BMC Proceedings 2013, 7(Suppl 4):S4. Alfred et al PMID:25073452 Cooper et al PMID:23818103 Elliott et al PMID: 24602970 Gardner 24365661 North 26671949 North 26831755 HALCyon Plain English Summary Brochure produced NDA findings brochure produced OUP book published - A life course approach to healthy ageing Production of meta-data and datasets https://discover.ukdataservice.ac.uk/catalogue/?sn=851494&type=Data%20catalogue One application approved for data sharing
Start Year 2008
 
Description Healthy Ageing Across the Life course (HALCyon) 
Organisation McGill University
Country Canada 
Sector Academic/University 
PI Contribution Diana Kuh is the PI of this interdisciplinary collaboration of scientists investigating the life course determinants of healthy ageing in 9 UK cohort studies. Rebecca Hardy leads the methodological core and the capability work package. Marcus Richards leads the knowledge transfer component and co-leads the nutritional work package. Gita Mishra is a member of the nutritional and wellbeing work packages. 2 postdoctoral scientists are HALCyon-funded.
Collaborator Contribution Yoav Ben-Shlomo in Bristol leads on the biology of ageing work packages for HALCyon, provides cohort data.Prof Thomas Zyglinivki leads the corss cohort HALCyon work package on telomeresProf Avan Aihie Sayer contributes to the HALCyon capability work package. Dr Catherine Gale leads the HALCyon wellbeing work package. Prof Cyrus Cooper is a co-investigator. Provide cohort data.HALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorCo-lead of HALCyon nutrition work packageHALCyon co-investigator for geocodingHALCyon co-investigator provides Lothian cohort dataHALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorExpertise in geriatric medicine and frailtyExpertise on ageing
Impact Several workshops and publications. Symposium - April 2010 Conference - Nov 2010 Conference- June 2012 Workshop - September 2012 Numerous published papers have used the data from other cohorts and other researcher have contributed to the production of these research papers. Data sent to external scientists 2016 21542061 21332924 21297868 22114723 20843964 22253814 23072920 22970320 22923606 22658392 22326597 22209408 21349224 21764771 21737047 21860018 20829298 20843964 19864640 23108707 21225350 22415954 21416275 22923606 17634317 20214846 23468552 23072920 23894584 23818103 22658392 23922731 23437142 Kuh et al: A life course approach to physical capability: findings from the HALCyon research programme. Bode and Scheidt-Nave (eds): European Workshop on Health and Disability Surveillance in Ageing Populations (EUWAP). BMC Proceedings 2013, Volume 7, Supplement 4:S4 BMC Proceedings 2013, 7(Suppl 4):S4. Alfred et al PMID:25073452 Cooper et al PMID:23818103 Elliott et al PMID: 24602970 Gardner 24365661 North 26671949 North 26831755 HALCyon Plain English Summary Brochure produced NDA findings brochure produced OUP book published - A life course approach to healthy ageing Production of meta-data and datasets https://discover.ukdataservice.ac.uk/catalogue/?sn=851494&type=Data%20catalogue One application approved for data sharing
Start Year 2008
 
Description Healthy Ageing Across the Life course (HALCyon) 
Organisation Medical Research Council (MRC)
Department MRC Human Nutrition Research Unit
Country United Kingdom 
Sector Public 
PI Contribution Diana Kuh is the PI of this interdisciplinary collaboration of scientists investigating the life course determinants of healthy ageing in 9 UK cohort studies. Rebecca Hardy leads the methodological core and the capability work package. Marcus Richards leads the knowledge transfer component and co-leads the nutritional work package. Gita Mishra is a member of the nutritional and wellbeing work packages. 2 postdoctoral scientists are HALCyon-funded.
Collaborator Contribution Yoav Ben-Shlomo in Bristol leads on the biology of ageing work packages for HALCyon, provides cohort data.Prof Thomas Zyglinivki leads the corss cohort HALCyon work package on telomeresProf Avan Aihie Sayer contributes to the HALCyon capability work package. Dr Catherine Gale leads the HALCyon wellbeing work package. Prof Cyrus Cooper is a co-investigator. Provide cohort data.HALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorCo-lead of HALCyon nutrition work packageHALCyon co-investigator for geocodingHALCyon co-investigator provides Lothian cohort dataHALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorExpertise in geriatric medicine and frailtyExpertise on ageing
Impact Several workshops and publications. Symposium - April 2010 Conference - Nov 2010 Conference- June 2012 Workshop - September 2012 Numerous published papers have used the data from other cohorts and other researcher have contributed to the production of these research papers. Data sent to external scientists 2016 21542061 21332924 21297868 22114723 20843964 22253814 23072920 22970320 22923606 22658392 22326597 22209408 21349224 21764771 21737047 21860018 20829298 20843964 19864640 23108707 21225350 22415954 21416275 22923606 17634317 20214846 23468552 23072920 23894584 23818103 22658392 23922731 23437142 Kuh et al: A life course approach to physical capability: findings from the HALCyon research programme. Bode and Scheidt-Nave (eds): European Workshop on Health and Disability Surveillance in Ageing Populations (EUWAP). BMC Proceedings 2013, Volume 7, Supplement 4:S4 BMC Proceedings 2013, 7(Suppl 4):S4. Alfred et al PMID:25073452 Cooper et al PMID:23818103 Elliott et al PMID: 24602970 Gardner 24365661 North 26671949 North 26831755 HALCyon Plain English Summary Brochure produced NDA findings brochure produced OUP book published - A life course approach to healthy ageing Production of meta-data and datasets https://discover.ukdataservice.ac.uk/catalogue/?sn=851494&type=Data%20catalogue One application approved for data sharing
Start Year 2008
 
Description Healthy Ageing Across the Life course (HALCyon) 
Organisation National Institute on Aging
Country United States 
Sector Public 
PI Contribution Diana Kuh is the PI of this interdisciplinary collaboration of scientists investigating the life course determinants of healthy ageing in 9 UK cohort studies. Rebecca Hardy leads the methodological core and the capability work package. Marcus Richards leads the knowledge transfer component and co-leads the nutritional work package. Gita Mishra is a member of the nutritional and wellbeing work packages. 2 postdoctoral scientists are HALCyon-funded.
Collaborator Contribution Yoav Ben-Shlomo in Bristol leads on the biology of ageing work packages for HALCyon, provides cohort data.Prof Thomas Zyglinivki leads the corss cohort HALCyon work package on telomeresProf Avan Aihie Sayer contributes to the HALCyon capability work package. Dr Catherine Gale leads the HALCyon wellbeing work package. Prof Cyrus Cooper is a co-investigator. Provide cohort data.HALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorCo-lead of HALCyon nutrition work packageHALCyon co-investigator for geocodingHALCyon co-investigator provides Lothian cohort dataHALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorExpertise in geriatric medicine and frailtyExpertise on ageing
Impact Several workshops and publications. Symposium - April 2010 Conference - Nov 2010 Conference- June 2012 Workshop - September 2012 Numerous published papers have used the data from other cohorts and other researcher have contributed to the production of these research papers. Data sent to external scientists 2016 21542061 21332924 21297868 22114723 20843964 22253814 23072920 22970320 22923606 22658392 22326597 22209408 21349224 21764771 21737047 21860018 20829298 20843964 19864640 23108707 21225350 22415954 21416275 22923606 17634317 20214846 23468552 23072920 23894584 23818103 22658392 23922731 23437142 Kuh et al: A life course approach to physical capability: findings from the HALCyon research programme. Bode and Scheidt-Nave (eds): European Workshop on Health and Disability Surveillance in Ageing Populations (EUWAP). BMC Proceedings 2013, Volume 7, Supplement 4:S4 BMC Proceedings 2013, 7(Suppl 4):S4. Alfred et al PMID:25073452 Cooper et al PMID:23818103 Elliott et al PMID: 24602970 Gardner 24365661 North 26671949 North 26831755 HALCyon Plain English Summary Brochure produced NDA findings brochure produced OUP book published - A life course approach to healthy ageing Production of meta-data and datasets https://discover.ukdataservice.ac.uk/catalogue/?sn=851494&type=Data%20catalogue One application approved for data sharing
Start Year 2008
 
Description Healthy Ageing Across the Life course (HALCyon) 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution Diana Kuh is the PI of this interdisciplinary collaboration of scientists investigating the life course determinants of healthy ageing in 9 UK cohort studies. Rebecca Hardy leads the methodological core and the capability work package. Marcus Richards leads the knowledge transfer component and co-leads the nutritional work package. Gita Mishra is a member of the nutritional and wellbeing work packages. 2 postdoctoral scientists are HALCyon-funded.
Collaborator Contribution Yoav Ben-Shlomo in Bristol leads on the biology of ageing work packages for HALCyon, provides cohort data.Prof Thomas Zyglinivki leads the corss cohort HALCyon work package on telomeresProf Avan Aihie Sayer contributes to the HALCyon capability work package. Dr Catherine Gale leads the HALCyon wellbeing work package. Prof Cyrus Cooper is a co-investigator. Provide cohort data.HALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorCo-lead of HALCyon nutrition work packageHALCyon co-investigator for geocodingHALCyon co-investigator provides Lothian cohort dataHALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorExpertise in geriatric medicine and frailtyExpertise on ageing
Impact Several workshops and publications. Symposium - April 2010 Conference - Nov 2010 Conference- June 2012 Workshop - September 2012 Numerous published papers have used the data from other cohorts and other researcher have contributed to the production of these research papers. Data sent to external scientists 2016 21542061 21332924 21297868 22114723 20843964 22253814 23072920 22970320 22923606 22658392 22326597 22209408 21349224 21764771 21737047 21860018 20829298 20843964 19864640 23108707 21225350 22415954 21416275 22923606 17634317 20214846 23468552 23072920 23894584 23818103 22658392 23922731 23437142 Kuh et al: A life course approach to physical capability: findings from the HALCyon research programme. Bode and Scheidt-Nave (eds): European Workshop on Health and Disability Surveillance in Ageing Populations (EUWAP). BMC Proceedings 2013, Volume 7, Supplement 4:S4 BMC Proceedings 2013, 7(Suppl 4):S4. Alfred et al PMID:25073452 Cooper et al PMID:23818103 Elliott et al PMID: 24602970 Gardner 24365661 North 26671949 North 26831755 HALCyon Plain English Summary Brochure produced NDA findings brochure produced OUP book published - A life course approach to healthy ageing Production of meta-data and datasets https://discover.ukdataservice.ac.uk/catalogue/?sn=851494&type=Data%20catalogue One application approved for data sharing
Start Year 2008
 
Description Healthy Ageing Across the Life course (HALCyon) 
Organisation University College London
Department Institute of Child Health
Country United Kingdom 
Sector Academic/University 
PI Contribution Diana Kuh is the PI of this interdisciplinary collaboration of scientists investigating the life course determinants of healthy ageing in 9 UK cohort studies. Rebecca Hardy leads the methodological core and the capability work package. Marcus Richards leads the knowledge transfer component and co-leads the nutritional work package. Gita Mishra is a member of the nutritional and wellbeing work packages. 2 postdoctoral scientists are HALCyon-funded.
Collaborator Contribution Yoav Ben-Shlomo in Bristol leads on the biology of ageing work packages for HALCyon, provides cohort data.Prof Thomas Zyglinivki leads the corss cohort HALCyon work package on telomeresProf Avan Aihie Sayer contributes to the HALCyon capability work package. Dr Catherine Gale leads the HALCyon wellbeing work package. Prof Cyrus Cooper is a co-investigator. Provide cohort data.HALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorCo-lead of HALCyon nutrition work packageHALCyon co-investigator for geocodingHALCyon co-investigator provides Lothian cohort dataHALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorExpertise in geriatric medicine and frailtyExpertise on ageing
Impact Several workshops and publications. Symposium - April 2010 Conference - Nov 2010 Conference- June 2012 Workshop - September 2012 Numerous published papers have used the data from other cohorts and other researcher have contributed to the production of these research papers. Data sent to external scientists 2016 21542061 21332924 21297868 22114723 20843964 22253814 23072920 22970320 22923606 22658392 22326597 22209408 21349224 21764771 21737047 21860018 20829298 20843964 19864640 23108707 21225350 22415954 21416275 22923606 17634317 20214846 23468552 23072920 23894584 23818103 22658392 23922731 23437142 Kuh et al: A life course approach to physical capability: findings from the HALCyon research programme. Bode and Scheidt-Nave (eds): European Workshop on Health and Disability Surveillance in Ageing Populations (EUWAP). BMC Proceedings 2013, Volume 7, Supplement 4:S4 BMC Proceedings 2013, 7(Suppl 4):S4. Alfred et al PMID:25073452 Cooper et al PMID:23818103 Elliott et al PMID: 24602970 Gardner 24365661 North 26671949 North 26831755 HALCyon Plain English Summary Brochure produced NDA findings brochure produced OUP book published - A life course approach to healthy ageing Production of meta-data and datasets https://discover.ukdataservice.ac.uk/catalogue/?sn=851494&type=Data%20catalogue One application approved for data sharing
Start Year 2008
 
Description Healthy Ageing Across the Life course (HALCyon) 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Diana Kuh is the PI of this interdisciplinary collaboration of scientists investigating the life course determinants of healthy ageing in 9 UK cohort studies. Rebecca Hardy leads the methodological core and the capability work package. Marcus Richards leads the knowledge transfer component and co-leads the nutritional work package. Gita Mishra is a member of the nutritional and wellbeing work packages. 2 postdoctoral scientists are HALCyon-funded.
Collaborator Contribution Yoav Ben-Shlomo in Bristol leads on the biology of ageing work packages for HALCyon, provides cohort data.Prof Thomas Zyglinivki leads the corss cohort HALCyon work package on telomeresProf Avan Aihie Sayer contributes to the HALCyon capability work package. Dr Catherine Gale leads the HALCyon wellbeing work package. Prof Cyrus Cooper is a co-investigator. Provide cohort data.HALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorCo-lead of HALCyon nutrition work packageHALCyon co-investigator for geocodingHALCyon co-investigator provides Lothian cohort dataHALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorExpertise in geriatric medicine and frailtyExpertise on ageing
Impact Several workshops and publications. Symposium - April 2010 Conference - Nov 2010 Conference- June 2012 Workshop - September 2012 Numerous published papers have used the data from other cohorts and other researcher have contributed to the production of these research papers. Data sent to external scientists 2016 21542061 21332924 21297868 22114723 20843964 22253814 23072920 22970320 22923606 22658392 22326597 22209408 21349224 21764771 21737047 21860018 20829298 20843964 19864640 23108707 21225350 22415954 21416275 22923606 17634317 20214846 23468552 23072920 23894584 23818103 22658392 23922731 23437142 Kuh et al: A life course approach to physical capability: findings from the HALCyon research programme. Bode and Scheidt-Nave (eds): European Workshop on Health and Disability Surveillance in Ageing Populations (EUWAP). BMC Proceedings 2013, Volume 7, Supplement 4:S4 BMC Proceedings 2013, 7(Suppl 4):S4. Alfred et al PMID:25073452 Cooper et al PMID:23818103 Elliott et al PMID: 24602970 Gardner 24365661 North 26671949 North 26831755 HALCyon Plain English Summary Brochure produced NDA findings brochure produced OUP book published - A life course approach to healthy ageing Production of meta-data and datasets https://discover.ukdataservice.ac.uk/catalogue/?sn=851494&type=Data%20catalogue One application approved for data sharing
Start Year 2008
 
Description Healthy Ageing Across the Life course (HALCyon) 
Organisation University of Aberdeen
Country United Kingdom 
Sector Academic/University 
PI Contribution Diana Kuh is the PI of this interdisciplinary collaboration of scientists investigating the life course determinants of healthy ageing in 9 UK cohort studies. Rebecca Hardy leads the methodological core and the capability work package. Marcus Richards leads the knowledge transfer component and co-leads the nutritional work package. Gita Mishra is a member of the nutritional and wellbeing work packages. 2 postdoctoral scientists are HALCyon-funded.
Collaborator Contribution Yoav Ben-Shlomo in Bristol leads on the biology of ageing work packages for HALCyon, provides cohort data.Prof Thomas Zyglinivki leads the corss cohort HALCyon work package on telomeresProf Avan Aihie Sayer contributes to the HALCyon capability work package. Dr Catherine Gale leads the HALCyon wellbeing work package. Prof Cyrus Cooper is a co-investigator. Provide cohort data.HALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorCo-lead of HALCyon nutrition work packageHALCyon co-investigator for geocodingHALCyon co-investigator provides Lothian cohort dataHALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorExpertise in geriatric medicine and frailtyExpertise on ageing
Impact Several workshops and publications. Symposium - April 2010 Conference - Nov 2010 Conference- June 2012 Workshop - September 2012 Numerous published papers have used the data from other cohorts and other researcher have contributed to the production of these research papers. Data sent to external scientists 2016 21542061 21332924 21297868 22114723 20843964 22253814 23072920 22970320 22923606 22658392 22326597 22209408 21349224 21764771 21737047 21860018 20829298 20843964 19864640 23108707 21225350 22415954 21416275 22923606 17634317 20214846 23468552 23072920 23894584 23818103 22658392 23922731 23437142 Kuh et al: A life course approach to physical capability: findings from the HALCyon research programme. Bode and Scheidt-Nave (eds): European Workshop on Health and Disability Surveillance in Ageing Populations (EUWAP). BMC Proceedings 2013, Volume 7, Supplement 4:S4 BMC Proceedings 2013, 7(Suppl 4):S4. Alfred et al PMID:25073452 Cooper et al PMID:23818103 Elliott et al PMID: 24602970 Gardner 24365661 North 26671949 North 26831755 HALCyon Plain English Summary Brochure produced NDA findings brochure produced OUP book published - A life course approach to healthy ageing Production of meta-data and datasets https://discover.ukdataservice.ac.uk/catalogue/?sn=851494&type=Data%20catalogue One application approved for data sharing
Start Year 2008
 
Description Healthy Ageing Across the Life course (HALCyon) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Diana Kuh is the PI of this interdisciplinary collaboration of scientists investigating the life course determinants of healthy ageing in 9 UK cohort studies. Rebecca Hardy leads the methodological core and the capability work package. Marcus Richards leads the knowledge transfer component and co-leads the nutritional work package. Gita Mishra is a member of the nutritional and wellbeing work packages. 2 postdoctoral scientists are HALCyon-funded.
Collaborator Contribution Yoav Ben-Shlomo in Bristol leads on the biology of ageing work packages for HALCyon, provides cohort data.Prof Thomas Zyglinivki leads the corss cohort HALCyon work package on telomeresProf Avan Aihie Sayer contributes to the HALCyon capability work package. Dr Catherine Gale leads the HALCyon wellbeing work package. Prof Cyrus Cooper is a co-investigator. Provide cohort data.HALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorCo-lead of HALCyon nutrition work packageHALCyon co-investigator for geocodingHALCyon co-investigator provides Lothian cohort dataHALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorExpertise in geriatric medicine and frailtyExpertise on ageing
Impact Several workshops and publications. Symposium - April 2010 Conference - Nov 2010 Conference- June 2012 Workshop - September 2012 Numerous published papers have used the data from other cohorts and other researcher have contributed to the production of these research papers. Data sent to external scientists 2016 21542061 21332924 21297868 22114723 20843964 22253814 23072920 22970320 22923606 22658392 22326597 22209408 21349224 21764771 21737047 21860018 20829298 20843964 19864640 23108707 21225350 22415954 21416275 22923606 17634317 20214846 23468552 23072920 23894584 23818103 22658392 23922731 23437142 Kuh et al: A life course approach to physical capability: findings from the HALCyon research programme. Bode and Scheidt-Nave (eds): European Workshop on Health and Disability Surveillance in Ageing Populations (EUWAP). BMC Proceedings 2013, Volume 7, Supplement 4:S4 BMC Proceedings 2013, 7(Suppl 4):S4. Alfred et al PMID:25073452 Cooper et al PMID:23818103 Elliott et al PMID: 24602970 Gardner 24365661 North 26671949 North 26831755 HALCyon Plain English Summary Brochure produced NDA findings brochure produced OUP book published - A life course approach to healthy ageing Production of meta-data and datasets https://discover.ukdataservice.ac.uk/catalogue/?sn=851494&type=Data%20catalogue One application approved for data sharing
Start Year 2008
 
Description Healthy Ageing Across the Life course (HALCyon) 
Organisation University of Cambridge
Department MRC Epidemiology Unit
Country United Kingdom 
Sector Multiple 
PI Contribution Diana Kuh is the PI of this interdisciplinary collaboration of scientists investigating the life course determinants of healthy ageing in 9 UK cohort studies. Rebecca Hardy leads the methodological core and the capability work package. Marcus Richards leads the knowledge transfer component and co-leads the nutritional work package. Gita Mishra is a member of the nutritional and wellbeing work packages. 2 postdoctoral scientists are HALCyon-funded.
Collaborator Contribution Yoav Ben-Shlomo in Bristol leads on the biology of ageing work packages for HALCyon, provides cohort data.Prof Thomas Zyglinivki leads the corss cohort HALCyon work package on telomeresProf Avan Aihie Sayer contributes to the HALCyon capability work package. Dr Catherine Gale leads the HALCyon wellbeing work package. Prof Cyrus Cooper is a co-investigator. Provide cohort data.HALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorCo-lead of HALCyon nutrition work packageHALCyon co-investigator for geocodingHALCyon co-investigator provides Lothian cohort dataHALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorExpertise in geriatric medicine and frailtyExpertise on ageing
Impact Several workshops and publications. Symposium - April 2010 Conference - Nov 2010 Conference- June 2012 Workshop - September 2012 Numerous published papers have used the data from other cohorts and other researcher have contributed to the production of these research papers. Data sent to external scientists 2016 21542061 21332924 21297868 22114723 20843964 22253814 23072920 22970320 22923606 22658392 22326597 22209408 21349224 21764771 21737047 21860018 20829298 20843964 19864640 23108707 21225350 22415954 21416275 22923606 17634317 20214846 23468552 23072920 23894584 23818103 22658392 23922731 23437142 Kuh et al: A life course approach to physical capability: findings from the HALCyon research programme. Bode and Scheidt-Nave (eds): European Workshop on Health and Disability Surveillance in Ageing Populations (EUWAP). BMC Proceedings 2013, Volume 7, Supplement 4:S4 BMC Proceedings 2013, 7(Suppl 4):S4. Alfred et al PMID:25073452 Cooper et al PMID:23818103 Elliott et al PMID: 24602970 Gardner 24365661 North 26671949 North 26831755 HALCyon Plain English Summary Brochure produced NDA findings brochure produced OUP book published - A life course approach to healthy ageing Production of meta-data and datasets https://discover.ukdataservice.ac.uk/catalogue/?sn=851494&type=Data%20catalogue One application approved for data sharing
Start Year 2008
 
Description Healthy Ageing Across the Life course (HALCyon) 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Diana Kuh is the PI of this interdisciplinary collaboration of scientists investigating the life course determinants of healthy ageing in 9 UK cohort studies. Rebecca Hardy leads the methodological core and the capability work package. Marcus Richards leads the knowledge transfer component and co-leads the nutritional work package. Gita Mishra is a member of the nutritional and wellbeing work packages. 2 postdoctoral scientists are HALCyon-funded.
Collaborator Contribution Yoav Ben-Shlomo in Bristol leads on the biology of ageing work packages for HALCyon, provides cohort data.Prof Thomas Zyglinivki leads the corss cohort HALCyon work package on telomeresProf Avan Aihie Sayer contributes to the HALCyon capability work package. Dr Catherine Gale leads the HALCyon wellbeing work package. Prof Cyrus Cooper is a co-investigator. Provide cohort data.HALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorCo-lead of HALCyon nutrition work packageHALCyon co-investigator for geocodingHALCyon co-investigator provides Lothian cohort dataHALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorExpertise in geriatric medicine and frailtyExpertise on ageing
Impact Several workshops and publications. Symposium - April 2010 Conference - Nov 2010 Conference- June 2012 Workshop - September 2012 Numerous published papers have used the data from other cohorts and other researcher have contributed to the production of these research papers. Data sent to external scientists 2016 21542061 21332924 21297868 22114723 20843964 22253814 23072920 22970320 22923606 22658392 22326597 22209408 21349224 21764771 21737047 21860018 20829298 20843964 19864640 23108707 21225350 22415954 21416275 22923606 17634317 20214846 23468552 23072920 23894584 23818103 22658392 23922731 23437142 Kuh et al: A life course approach to physical capability: findings from the HALCyon research programme. Bode and Scheidt-Nave (eds): European Workshop on Health and Disability Surveillance in Ageing Populations (EUWAP). BMC Proceedings 2013, Volume 7, Supplement 4:S4 BMC Proceedings 2013, 7(Suppl 4):S4. Alfred et al PMID:25073452 Cooper et al PMID:23818103 Elliott et al PMID: 24602970 Gardner 24365661 North 26671949 North 26831755 HALCyon Plain English Summary Brochure produced NDA findings brochure produced OUP book published - A life course approach to healthy ageing Production of meta-data and datasets https://discover.ukdataservice.ac.uk/catalogue/?sn=851494&type=Data%20catalogue One application approved for data sharing
Start Year 2008
 
Description Healthy Ageing Across the Life course (HALCyon) 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution Diana Kuh is the PI of this interdisciplinary collaboration of scientists investigating the life course determinants of healthy ageing in 9 UK cohort studies. Rebecca Hardy leads the methodological core and the capability work package. Marcus Richards leads the knowledge transfer component and co-leads the nutritional work package. Gita Mishra is a member of the nutritional and wellbeing work packages. 2 postdoctoral scientists are HALCyon-funded.
Collaborator Contribution Yoav Ben-Shlomo in Bristol leads on the biology of ageing work packages for HALCyon, provides cohort data.Prof Thomas Zyglinivki leads the corss cohort HALCyon work package on telomeresProf Avan Aihie Sayer contributes to the HALCyon capability work package. Dr Catherine Gale leads the HALCyon wellbeing work package. Prof Cyrus Cooper is a co-investigator. Provide cohort data.HALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorCo-lead of HALCyon nutrition work packageHALCyon co-investigator for geocodingHALCyon co-investigator provides Lothian cohort dataHALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorExpertise in geriatric medicine and frailtyExpertise on ageing
Impact Several workshops and publications. Symposium - April 2010 Conference - Nov 2010 Conference- June 2012 Workshop - September 2012 Numerous published papers have used the data from other cohorts and other researcher have contributed to the production of these research papers. Data sent to external scientists 2016 21542061 21332924 21297868 22114723 20843964 22253814 23072920 22970320 22923606 22658392 22326597 22209408 21349224 21764771 21737047 21860018 20829298 20843964 19864640 23108707 21225350 22415954 21416275 22923606 17634317 20214846 23468552 23072920 23894584 23818103 22658392 23922731 23437142 Kuh et al: A life course approach to physical capability: findings from the HALCyon research programme. Bode and Scheidt-Nave (eds): European Workshop on Health and Disability Surveillance in Ageing Populations (EUWAP). BMC Proceedings 2013, Volume 7, Supplement 4:S4 BMC Proceedings 2013, 7(Suppl 4):S4. Alfred et al PMID:25073452 Cooper et al PMID:23818103 Elliott et al PMID: 24602970 Gardner 24365661 North 26671949 North 26831755 HALCyon Plain English Summary Brochure produced NDA findings brochure produced OUP book published - A life course approach to healthy ageing Production of meta-data and datasets https://discover.ukdataservice.ac.uk/catalogue/?sn=851494&type=Data%20catalogue One application approved for data sharing
Start Year 2008
 
Description Healthy Ageing Across the Life course (HALCyon) 
Organisation University of London
Department Institute of Education
Country United Kingdom 
Sector Academic/University 
PI Contribution Diana Kuh is the PI of this interdisciplinary collaboration of scientists investigating the life course determinants of healthy ageing in 9 UK cohort studies. Rebecca Hardy leads the methodological core and the capability work package. Marcus Richards leads the knowledge transfer component and co-leads the nutritional work package. Gita Mishra is a member of the nutritional and wellbeing work packages. 2 postdoctoral scientists are HALCyon-funded.
Collaborator Contribution Yoav Ben-Shlomo in Bristol leads on the biology of ageing work packages for HALCyon, provides cohort data.Prof Thomas Zyglinivki leads the corss cohort HALCyon work package on telomeresProf Avan Aihie Sayer contributes to the HALCyon capability work package. Dr Catherine Gale leads the HALCyon wellbeing work package. Prof Cyrus Cooper is a co-investigator. Provide cohort data.HALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorCo-lead of HALCyon nutrition work packageHALCyon co-investigator for geocodingHALCyon co-investigator provides Lothian cohort dataHALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorExpertise in geriatric medicine and frailtyExpertise on ageing
Impact Several workshops and publications. Symposium - April 2010 Conference - Nov 2010 Conference- June 2012 Workshop - September 2012 Numerous published papers have used the data from other cohorts and other researcher have contributed to the production of these research papers. Data sent to external scientists 2016 21542061 21332924 21297868 22114723 20843964 22253814 23072920 22970320 22923606 22658392 22326597 22209408 21349224 21764771 21737047 21860018 20829298 20843964 19864640 23108707 21225350 22415954 21416275 22923606 17634317 20214846 23468552 23072920 23894584 23818103 22658392 23922731 23437142 Kuh et al: A life course approach to physical capability: findings from the HALCyon research programme. Bode and Scheidt-Nave (eds): European Workshop on Health and Disability Surveillance in Ageing Populations (EUWAP). BMC Proceedings 2013, Volume 7, Supplement 4:S4 BMC Proceedings 2013, 7(Suppl 4):S4. Alfred et al PMID:25073452 Cooper et al PMID:23818103 Elliott et al PMID: 24602970 Gardner 24365661 North 26671949 North 26831755 HALCyon Plain English Summary Brochure produced NDA findings brochure produced OUP book published - A life course approach to healthy ageing Production of meta-data and datasets https://discover.ukdataservice.ac.uk/catalogue/?sn=851494&type=Data%20catalogue One application approved for data sharing
Start Year 2008
 
Description Healthy Ageing Across the Life course (HALCyon) 
Organisation University of Portsmouth
Country United Kingdom 
Sector Academic/University 
PI Contribution Diana Kuh is the PI of this interdisciplinary collaboration of scientists investigating the life course determinants of healthy ageing in 9 UK cohort studies. Rebecca Hardy leads the methodological core and the capability work package. Marcus Richards leads the knowledge transfer component and co-leads the nutritional work package. Gita Mishra is a member of the nutritional and wellbeing work packages. 2 postdoctoral scientists are HALCyon-funded.
Collaborator Contribution Yoav Ben-Shlomo in Bristol leads on the biology of ageing work packages for HALCyon, provides cohort data.Prof Thomas Zyglinivki leads the corss cohort HALCyon work package on telomeresProf Avan Aihie Sayer contributes to the HALCyon capability work package. Dr Catherine Gale leads the HALCyon wellbeing work package. Prof Cyrus Cooper is a co-investigator. Provide cohort data.HALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorCo-lead of HALCyon nutrition work packageHALCyon co-investigator for geocodingHALCyon co-investigator provides Lothian cohort dataHALCyon co-investigatorHALCyon co-investigatorHALCyon co-investigatorExpertise in geriatric medicine and frailtyExpertise on ageing
Impact Several workshops and publications. Symposium - April 2010 Conference - Nov 2010 Conference- June 2012 Workshop - September 2012 Numerous published papers have used the data from other cohorts and other researcher have contributed to the production of these research papers. Data sent to external scientists 2016 21542061 21332924 21297868 22114723 20843964 22253814 23072920 22970320 22923606 22658392 22326597 22209408 21349224 21764771 21737047 21860018 20829298 20843964 19864640 23108707 21225350 22415954 21416275 22923606 17634317 20214846 23468552 23072920 23894584 23818103 22658392 23922731 23437142 Kuh et al: A life course approach to physical capability: findings from the HALCyon research programme. Bode and Scheidt-Nave (eds): European Workshop on Health and Disability Surveillance in Ageing Populations (EUWAP). BMC Proceedings 2013, Volume 7, Supplement 4:S4 BMC Proceedings 2013, 7(Suppl 4):S4. Alfred et al PMID:25073452 Cooper et al PMID:23818103 Elliott et al PMID: 24602970 Gardner 24365661 North 26671949 North 26831755 HALCyon Plain English Summary Brochure produced NDA findings brochure produced OUP book published - A life course approach to healthy ageing Production of meta-data and datasets https://discover.ukdataservice.ac.uk/catalogue/?sn=851494&type=Data%20catalogue One application approved for data sharing
Start Year 2008
 
Description Hip and spine morphologies - Aberdeen Collaboration 
Organisation Manchester University NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Collboration to look at hip and spine morphologies in the NSHD. The unit will provide the study members for the project, help with coordination of the project, data analysis, creation and editing of manuscripts and writing grant applications.
Collaborator Contribution Coordination of the project, data analysis, creation and editing of manuscripts and writing grant applications.
Impact A grant application has been awarded by the MRC - November 2013 Aberdeen have finished deriving a complete dataset of hip shape mode scores and one on spine shape is due to be delivered soon. Conference abstracts have been submitted by the Aberdeen group LHA is now planning analyses that will be led by them Muthuri and Pavlova submitted papers abstracts submitted Muthuri SG.Associations between body mass index across adult life and hip shapes at age 60 to 64: Evidence from the 1946 British birth cohort.PMID:28842363 PMC5658512 Pavlova AV. Statistical shape modelling of hip and lumbar spine morphology and their relationship in the MRC National Survey of Health and Development.PMID:28561274 PMC5522893
Start Year 2013
 
Description Hip and spine morphologies - Aberdeen Collaboration 
Organisation University of Aberdeen
Country United Kingdom 
Sector Academic/University 
PI Contribution Collboration to look at hip and spine morphologies in the NSHD. The unit will provide the study members for the project, help with coordination of the project, data analysis, creation and editing of manuscripts and writing grant applications.
Collaborator Contribution Coordination of the project, data analysis, creation and editing of manuscripts and writing grant applications.
Impact A grant application has been awarded by the MRC - November 2013 Aberdeen have finished deriving a complete dataset of hip shape mode scores and one on spine shape is due to be delivered soon. Conference abstracts have been submitted by the Aberdeen group LHA is now planning analyses that will be led by them Muthuri and Pavlova submitted papers abstracts submitted Muthuri SG.Associations between body mass index across adult life and hip shapes at age 60 to 64: Evidence from the 1946 British birth cohort.PMID:28842363 PMC5658512 Pavlova AV. Statistical shape modelling of hip and lumbar spine morphology and their relationship in the MRC National Survey of Health and Development.PMID:28561274 PMC5522893
Start Year 2013
 
Description Incontinence collaboration (L Cardozza) 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Provide life course expertise, complete data analysis, manuscript preparation
Collaborator Contribution Provide expertise in incontinence research
Impact Tsui A. Vascular risk factors for male and female urgency urinary incontinence at age 68 years from a British birth cohort study.PMID: 29512315
Start Year 2016
 
Description Incontinence collaboration with Imperial 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution NSHD data sharing Help with interpretation and revision of manuscripts Contribute to the scientific development of the collaboration
Collaborator Contribution Analysis and interpretation of NSHD data Contribute to the scientific development of the collaboration Preparation of research papers
Impact NSHD data request has been approved The genotyping has been returned and we are just waiting on the collaborator to complete the analysis. Paper is about to be submitted
Start Year 2012
 
Description Insight 46 study 
Organisation University College London
Department Institute of Neurology
Country United Kingdom 
Sector Academic/University 
PI Contribution A subset of study members from NSHD will undergo positron emission tomography (PET) to detect early deposition of fibrillar beta-amyloid (Aß) and other misfolded proteins involved in the pathogenesis of Alzheimer's disease; (2) sensitive MRI techniques to measure early cortical and sub-cortical atrophy, cerebrovascular lesions, cerebral blood flow, and regional metabolic rate of oxygen. NSHD will coordinate the study and review the potential to add in additional assessments (auditory and visual) around this sub-study
Collaborator Contribution The PET scans and MRI techniques will be carried out by collaborators at Queens Square. They will also interpret the the scans. Our collaborators are also helping the initial organisation/logistics of the study.
Impact Funding from the Wolfson Foundation for a neuroimaging sub-study for 500 NSHD study members Grant application submitted but not successful to Welcome Trust Funding from ARUK for 3 day study manager and 1 day of senior study manager (128,000) Training, equipment and documents purchased/created Abstracts submitted to Alzheimer's Association International Conference, May 2017. 500 participants seen and wave 1 has been completed. Wave 2 started early 2018. Lane CA, Study protocol: Insight 46 - a neuroscience sub-study of the MRC National Survey of Health and Development.BMC Neurol. 2017 Apr 18;17(1):75. doi: 10.1186/s12883-017-0846-x. PMID:28420323
Start Year 2012
 
Description Integrative Analysis of Longitudinal Studies of Ageing 
Organisation University of Victoria
Country Australia 
Sector Academic/University 
PI Contribution Scientific contribution on cognitive and physical capability and modelling change over time. The Unit as well as HALCyon researchers joined forces with researchers on the Integrative Analysis of Longitudinal Studies of Aging (IALSA) network to continue the HALCyon network of cohorts. Data analysis, creating and editing manuscripts, knowledge exchange and grant writing.
Collaborator Contribution It has led to an important scientific collaboration with Prof Hofer who is PI of the IALSA network enhancing our methodological skills in analysis of change in longitudinal studies of ageing. Through his network and the joint workshop anda shared postdoc appointment, LHA will extend its links to international studies of ageing and undertake more cross cohort comparisons. Data analysis, creating and editing manuscripts, knowledge exchange and grant writing.
Impact This collaboration has led to a grant for a shared Canadian post doc under the CIHR NDA programme and a workshop of Canadian and LHA (HALCyon) scientists at Victoria BC. Successful grant application to NIH to combine HALCyon and IALSA networks. Publications 23349427 23108707 Bendayan PMID 27481931Self related health and memory decline Bendayan PMID 27753610 Hierarchy and speed of loss. Bendayan Decline in Memory, Visuospatial Ability, and Crystalized Cognitive Abilities in Older Adults: Normative Aging or Terminal Decline? PMID:28634548 Bendayan R. From acute to chronic back pain: Using linear mixed models to explore changes in pain intensity, disability, and depression. PMID: 28850411. Graham EK.Personality Predicts Mortality Risk: An Integrative Data Analysis of 15 PMID: 29230075 PMC5722274 NSHD data has been put on to the MAELSTROM data platform Collaboration with Melodem (Methods for dementia research). A number of papers have been submitted
Start Year 2007
 
Description Interconnect 
Organisation University of Cambridge
Department MRC Epidemiology Unit
Country United Kingdom 
Sector Multiple 
PI Contribution All those with responsibility for studies can play a central role, leading analyses across the network rather than simply providing data for others.
Collaborator Contribution InterConnect (www.interconnect-diabetes.eu) is a European Union FP-7 funded project that aims to change the way that data are used in population research into the causes of diabetes and obesity. It seeks to create the foundation to enable research to move from explaining the differences in risk of diabetes and obesity within populations to being able to explain differences in risk between populations.
Impact A new project is being undertaken that uses the interconnect approach with the MRC Epidemiology Unit in Cambridge
Start Year 2015
 
Description Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution UCL is the main partner for this collaboration NSHD data sharing, revision of manuscripts
Collaborator Contribution Analysis and interpretation of NSHD (and other) data Contribute to the scientific development of the collaboration Preparation of research papers
Impact PMID 22421340
Start Year 2011
 
Description Johns Hopkins Collaboration 
Organisation Johns Hopkins University
Country United States 
Sector Academic/University 
PI Contribution LHA have provided the NSHD Actiheart data for analysis and will help with writing/editing a set of research papers
Collaborator Contribution Johns Hopkins have been reprocessing and quality checking the NSHD Actiheart data and are now analysing it which will hopefully lead to a set of collaborative papers.
Impact Paper in press: Associations of contemporaneous BMI and obesity history with daily patterns of physical activity at 60-64 years: findings from a British birth cohort. Also presented findings from this collaboration at SSM and GSA in 2015 PMID 26957472 Assessing Daily Physical Activity in Older Adults: Unraveling the Complexity of Monitors, Measures, and Methods Cooper R. Obesity History and Daily Patterns of Physical Activity at Age 60-64 Years: Findings From the MRC National Survey of Health and Development. PMID: 28329086
Start Year 2013
 
Description Life course determinants of kidney function 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Clinical and epidemiological expertise as part of the scientific collaboration, new NSHD clinical data on renal function to be used in conjunction with existing NSHD life course data
Collaborator Contribution By starting a long term collaboration with Dr Dorothea Nitsch, a nephrologist and a postdoctoral scientist we will expand the clinical and analytical skills in the area of research on renal function
Impact Collaboration led to grant from KRUK on 'exploring early life course determinants of chronic kidney disease'
Start Year 2009
 
Description MND collaborations 
Organisation University College London
Department Institute of Neurology
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration on Motor Neuron Disease research - provide expertise and data, analysis, contribution to papers
Collaborator Contribution Collaboration on Motor Neuron Disease research - provide expertise and data, analysis, contribution to papers
Impact BRC Grant awarded £251,259 CHCHD10 Pro34Ser is not a pathogenic variant for amyotrophic lateral sclerosis and frontotemporal dementia.PMID 26362910
Start Year 2015
 
Description MRC guidelines on biomarkers of healthy ageing 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution Three LHA scientists contributed to the creation of the new MRC guidelines on biomarkers of healthy ageing and also helped to organise a workshop on the subject.
Collaborator Contribution The external collaborators also contributed to the creation of the new MRC guidelines on biomarkers of healthy ageing and helped to organise a workshop on the subject.
Impact Creation of the new MRC guidelines is still in progress - drafts are being circulated Kuh et al PMID: 24456831 PMID: 26373927
Start Year 2011
 
Description MRC guidelines on biomarkers of healthy ageing 
Organisation University of Birmingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Three LHA scientists contributed to the creation of the new MRC guidelines on biomarkers of healthy ageing and also helped to organise a workshop on the subject.
Collaborator Contribution The external collaborators also contributed to the creation of the new MRC guidelines on biomarkers of healthy ageing and helped to organise a workshop on the subject.
Impact Creation of the new MRC guidelines is still in progress - drafts are being circulated Kuh et al PMID: 24456831 PMID: 26373927
Start Year 2011
 
Description MRC guidelines on biomarkers of healthy ageing 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Three LHA scientists contributed to the creation of the new MRC guidelines on biomarkers of healthy ageing and also helped to organise a workshop on the subject.
Collaborator Contribution The external collaborators also contributed to the creation of the new MRC guidelines on biomarkers of healthy ageing and helped to organise a workshop on the subject.
Impact Creation of the new MRC guidelines is still in progress - drafts are being circulated Kuh et al PMID: 24456831 PMID: 26373927
Start Year 2011
 
Description MRC guidelines on biomarkers of healthy ageing 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Three LHA scientists contributed to the creation of the new MRC guidelines on biomarkers of healthy ageing and also helped to organise a workshop on the subject.
Collaborator Contribution The external collaborators also contributed to the creation of the new MRC guidelines on biomarkers of healthy ageing and helped to organise a workshop on the subject.
Impact Creation of the new MRC guidelines is still in progress - drafts are being circulated Kuh et al PMID: 24456831 PMID: 26373927
Start Year 2011
 
Description MW epigenetics 
Organisation University College London Hospitals NHS Foundation Trust
Department Gynaecological Oncology
Country United Kingdom 
Sector Hospitals 
PI Contribution Providing NSHD samples for epigenetic study. Writing grant applications. Helping with analysis and interpretation of results. Drafting and revision of papers. Enhancing NSHD resource.
Collaborator Contribution Will carry out NSHD epigenetic study on 1200 samples to look at DNA methylation funded by £150,000 grant from Eve appeal. Writing grant applications. Analysis and interpretation of results. Drafting and revision of papers. Enhancing NSHD resource.
Impact Funding from the Eve Appeal for NSHD epigenetic study - DNA methylation costs on 1200 samples. Anjum et al PMID:25067956 PMID:2618125 Yang PMID:27716309 Correlation of an epigenetic clock with cancer risk
Start Year 2011
 
Description Meta GWAS on wellbeing 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution NSHD data sharing Help with interpretation and revision of manuscripts Contribute to the scientific development of the collaboration
Collaborator Contribution Analysis and interpretation of NSHD data Contribute to the scientific development of the collaboration Preparation of research papers
Impact still under development
Start Year 2012
 
Description Montpellier Collaboration 
Organisation University of Montpellier
Country France 
Sector Academic/University 
PI Contribution Contributions will include providing data, data analysis, research advice, organising meetings, publication writing, grant applications, editing manuscripts and knowledge exchange
Collaborator Contribution Contributions will include providing data, data analysis, research advice, organising meetings, publication writing, grant applications, editing manuscripts and knowledge exchange
Impact Paper accepted in Thorax Meeting organised - Operative definition of active and healthy Ageing Oct 2014
Start Year 2013
 
Description NCD Risk Factor Collaboration 
Organisation Imperial College London
Department Imperial College Trust
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Provide NSHD data and advice on manuscript preparation and analysis
Collaborator Contribution Analysis of data and creation of manuscripts
Impact PMID 27061677 Trends in diabetes PMID 27458798 Adult human height PMID 27115820 Trends in adult BMI PMID 27863813 Trends in blood pressure NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in body mass index, underweight, overweight and obesity from 1975 to 2016: a pooled analysis of 2,416 population-based measurement studies with 128.9 million children, adolescents and adults.PMID: 29029897 NCD Risk Factor Collaboration 'Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants' International Journal of Epidemiology In press Most recent wave of data added in
Start Year 2016
 
Description NS collaboration with Queen Mary University 
Organisation Queen Mary University of London
Country United Kingdom 
Sector Academic/University 
PI Contribution Provide expertise, analysis, contribution to research papers and other research activities
Collaborator Contribution Provide expertise, analysis, contribution to research papers and other research activities
Impact Systemic inflammatory response and neuromuscular involvement in Amyotrophic Lateral Sclerosis.PMID 27308305
Start Year 2015
 
Description National Institute of Health, Bethesda (NS) 
Organisation National Institutes of Health (NIH)
Country United States 
Sector Public 
PI Contribution Provide expertise, analysis, contribution to research papers and other research activities
Collaborator Contribution Provide expertise, analysis, contribution to research papers and other research activities
Impact collaboraiton ongoing before PI started at the Unit Differential contribution of BA4a and BA4p to motor learning, Under review Human Brain Mapping
Start Year 2016
 
Description PHSRN Network 
Organisation University of Cambridge
Department MRC Epidemiology Unit
Country United Kingdom 
Sector Multiple 
PI Contribution Member of the PHSRN Network. Comment on proposals, help with organisation of events/training, work together on research projects
Collaborator Contribution The overall goals for the MRC Population Health Sciences Network (PHSRN) remain 1. To encourage collaborative research on key questions in the population health sciences. 2. To add value to members' individual work programmes and the MRC's overall investment in the population health sciences. 3. To provide a forum for discussing and responding to research and policy issues relating to population health. 4. To build research capacity in the population health sciences. The specific objectives of the next phase of PHSRN will be 1. To promote the development and dissemination of best practice in population health science through a continued programme of methodological knowledge exchange working collaboratively with other networks and stakeholders. 2. To lead the development of a series of frontier workshops aimed at synergising opportunities for the development of collaborative working on large-scale public health challenges. 3. To work collaboratively with other networks and groups to establish a UK flagship conference on methods and challenges in population health.
Impact Renewal of PHSRN funding grant application submitted
Start Year 2014
 
Description Personalised care for people with Parkinson's Disease 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration on research project, data analysis, submission of grant applications, manuscript preparation
Collaborator Contribution Collaboration on research project, data analysis, submission of grant applications, manuscript preparation
Impact NIHR Programme Grant awarded, DD Co-I
Start Year 2017
 
Description Queensland University -InterLACE and Womens Health 
Organisation Australia Ministry of Health
Department Australian Longitudinal Study on Women's Health
Country Australia 
Sector Academic/University 
PI Contribution The role of the International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease (InterLACE) is to advance the evidence base for women's health policy. Sharing NSHD data. Harmonizing data. Drafting and revision of papers. Providing epidemiological expertise.
Collaborator Contribution The role of the International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease (InterLACE) is to advance the evidence base for women's health policy. Data sharing. Harmonizing data. Drafting and revision of papers. Providing epidemiological expertise.
Impact PMID 18413433 PMID 16698159 PMID 17157388 PMID 16607095 PMID 16698977 PMID 17053289 PMID 18828667 PMID 22318435 PMID: 24670776 PMID:28119483 Early menarche, nulliparity and the risk for premature and early natural menopause PMID:27621257 Interlace design paper Chung HF.The role of sleep difficulties in the vasomotor menopausal symptoms and depressed mood relationships: an international pooled analysis of eight studies in the InterLACE consortium.PMID: 29429422 Papers in press
Start Year 2012
 
Description Queensland University -InterLACE and Womens Health 
Organisation Gunma University
Department Japan Nurses’ Health Study
Country Japan 
Sector Public 
PI Contribution The role of the International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease (InterLACE) is to advance the evidence base for women's health policy. Sharing NSHD data. Harmonizing data. Drafting and revision of papers. Providing epidemiological expertise.
Collaborator Contribution The role of the International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease (InterLACE) is to advance the evidence base for women's health policy. Data sharing. Harmonizing data. Drafting and revision of papers. Providing epidemiological expertise.
Impact PMID 18413433 PMID 16698159 PMID 17157388 PMID 16607095 PMID 16698977 PMID 17053289 PMID 18828667 PMID 22318435 PMID: 24670776 PMID:28119483 Early menarche, nulliparity and the risk for premature and early natural menopause PMID:27621257 Interlace design paper Chung HF.The role of sleep difficulties in the vasomotor menopausal symptoms and depressed mood relationships: an international pooled analysis of eight studies in the InterLACE consortium.PMID: 29429422 Papers in press
Start Year 2012
 
Description Queensland University -InterLACE and Womens Health 
Organisation Queensland University of Technology (QUT)
Department Healthy Ageing of Women Study
Country Australia 
Sector Academic/University 
PI Contribution The role of the International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease (InterLACE) is to advance the evidence base for women's health policy. Sharing NSHD data. Harmonizing data. Drafting and revision of papers. Providing epidemiological expertise.
Collaborator Contribution The role of the International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease (InterLACE) is to advance the evidence base for women's health policy. Data sharing. Harmonizing data. Drafting and revision of papers. Providing epidemiological expertise.
Impact PMID 18413433 PMID 16698159 PMID 17157388 PMID 16607095 PMID 16698977 PMID 17053289 PMID 18828667 PMID 22318435 PMID: 24670776 PMID:28119483 Early menarche, nulliparity and the risk for premature and early natural menopause PMID:27621257 Interlace design paper Chung HF.The role of sleep difficulties in the vasomotor menopausal symptoms and depressed mood relationships: an international pooled analysis of eight studies in the InterLACE consortium.PMID: 29429422 Papers in press
Start Year 2012
 
Description Queensland University -InterLACE and Womens Health 
Organisation Study of Women's Health Across the Nation SWAN
Country United States 
Sector Charity/Non Profit 
PI Contribution The role of the International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease (InterLACE) is to advance the evidence base for women's health policy. Sharing NSHD data. Harmonizing data. Drafting and revision of papers. Providing epidemiological expertise.
Collaborator Contribution The role of the International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease (InterLACE) is to advance the evidence base for women's health policy. Data sharing. Harmonizing data. Drafting and revision of papers. Providing epidemiological expertise.
Impact PMID 18413433 PMID 16698159 PMID 17157388 PMID 16607095 PMID 16698977 PMID 17053289 PMID 18828667 PMID 22318435 PMID: 24670776 PMID:28119483 Early menarche, nulliparity and the risk for premature and early natural menopause PMID:27621257 Interlace design paper Chung HF.The role of sleep difficulties in the vasomotor menopausal symptoms and depressed mood relationships: an international pooled analysis of eight studies in the InterLACE consortium.PMID: 29429422 Papers in press
Start Year 2012
 
Description Queensland University -InterLACE and Womens Health 
Organisation University College London
Department 1958 Birth Cohort/National Child Development Study
Country United Kingdom 
Sector Academic/University 
PI Contribution The role of the International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease (InterLACE) is to advance the evidence base for women's health policy. Sharing NSHD data. Harmonizing data. Drafting and revision of papers. Providing epidemiological expertise.
Collaborator Contribution The role of the International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease (InterLACE) is to advance the evidence base for women's health policy. Data sharing. Harmonizing data. Drafting and revision of papers. Providing epidemiological expertise.
Impact PMID 18413433 PMID 16698159 PMID 17157388 PMID 16607095 PMID 16698977 PMID 17053289 PMID 18828667 PMID 22318435 PMID: 24670776 PMID:28119483 Early menarche, nulliparity and the risk for premature and early natural menopause PMID:27621257 Interlace design paper Chung HF.The role of sleep difficulties in the vasomotor menopausal symptoms and depressed mood relationships: an international pooled analysis of eight studies in the InterLACE consortium.PMID: 29429422 Papers in press
Start Year 2012
 
Description Queensland University -InterLACE and Womens Health 
Organisation University of Leeds
Department UK Women's Cohort Study
Country United Kingdom 
Sector Academic/University 
PI Contribution The role of the International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease (InterLACE) is to advance the evidence base for women's health policy. Sharing NSHD data. Harmonizing data. Drafting and revision of papers. Providing epidemiological expertise.
Collaborator Contribution The role of the International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease (InterLACE) is to advance the evidence base for women's health policy. Data sharing. Harmonizing data. Drafting and revision of papers. Providing epidemiological expertise.
Impact PMID 18413433 PMID 16698159 PMID 17157388 PMID 16607095 PMID 16698977 PMID 17053289 PMID 18828667 PMID 22318435 PMID: 24670776 PMID:28119483 Early menarche, nulliparity and the risk for premature and early natural menopause PMID:27621257 Interlace design paper Chung HF.The role of sleep difficulties in the vasomotor menopausal symptoms and depressed mood relationships: an international pooled analysis of eight studies in the InterLACE consortium.PMID: 29429422 Papers in press
Start Year 2012
 
Description Secondment to MRC Research Data Support Service (DSS) Project 
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Secondment to the MRC Research Data Support Service (DSS) Project. One is Programme Manager for one year 50% FTE 1. Maximise the use of the Gateway by researchers by: - improving promotion and visibility of the Gateway - improving the experience of accessing and using the Gateway - increasing the publication of informative metadata into Gateway by engaging a further 10+ MRC 'strategic' cohorts - improving the quality of existing study information and metadata - facilitating easy acquisition of new sets of study and variable descriptions 2. Validate the utility of the Gateway to researchers by: - ensuring new uses and outputs are documented by studies - collecting feedback from a range of users 3. Coordinate development, validation and implementation of metadata standards and tools by: - working with CLOSER (ESRC / MRC funded Cohort and Longitudinal Studies Enhancement Resources) and UK Data Service (UKDS) for the Population Health Science (PHS) community - working with MRC Head Office to ensure coordination with related metadata initiatives for patient / clinical cohorts and data discovery and sharing with omics / bioinformatics imaging and e-health. - engaging with research, informatics and data management communities and with stakeholder organisations e.g. JISC, EBI - aligning DSS and CLOSER search platforms within a wider system of interoperable data and tissue services. 4. Promote and support the implementation of MRC Research Data policy by: - enabling studies to publish metadata by providing initial assistance and tools for ingest - providing examples of good practice - identifying needs and feeding into the wider MRC policy
Collaborator Contribution Members of the MRC will work with the seconded staff to complete the project and objectives listed in the above contribution section
Impact none
Start Year 2013
 
Description Smoking collaboration with Bristol University 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution NSHD data sharing Contribute to the scientific development of the project Interpretation and revision of manuscripts
Collaborator Contribution Analysis and interpretation of data Preparation of manuscripts
Impact still under development Data requests have been sent to NSHD
Start Year 2012
 
Description Sobell Movement disorder lab, ION 
Organisation University College London
Department Institute of Neurology
Country United Kingdom 
Sector Academic/University 
PI Contribution Provide expertise, analysis, contribution to research papers and other research activities
Collaborator Contribution Provide expertise, analysis, contribution to research papers and other research activities
Impact none to report
Start Year 2015
 
Description Springboard Fellowship/Kings Collaboration PP 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Provided NSHD data and life course expertise.
Collaborator Contribution Analysis of data and genomics expertise
Impact UCL Springboard Fellowship awarded Paper is production Abstracts submitted and talks completed
Start Year 2016
 
Description The Genetic Investigation of Anthropometric Traits (GIANT/MAGIC) consortium 
Organisation Broad Institute
Country United States 
Sector Charity/Non Profit 
PI Contribution The Genetic Investigation of ANthropometric Traits (GIANT) consortium is an international collaboration that seeks to identify genetic loci that modulate human body size and shape, including height and measures of obesity. The GIANT consortium is a collaboration between investigators from many different groups, institutions, countries, and studies, and the results represent their combined efforts. The primary approach has been meta-analysis of genome-wide association data and other large-scale genetic data sets. Anthropometric traits that have been studied by GIANT include body mass index (BMI), height, and traits related to waist circumference (such as waist-hip ratio adjusted for BMI, or WHRadjBMI). A full list of cohorts involved can be found here http://www.broadinstitute.org/collaboration/giant/index.php/GIANT_Cohorts_and_Groups The Unit contributes data from the NSHD and comments on publications.
Collaborator Contribution Data analysis, creation and editing of manuscripts.
Impact Thus far, the GIANT consortium has identified common genetic variants at hundreds of loci that are associated with anthropometric traits. Publication Randall et al PMID:23754948 Wood et al PMID: 25282103 Shungin PMID:25673412 Locke PMID: 25673413 Zimmerman PMID:25752329 Reid PMID:27876822 Justice A et al. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nat Commun. 2017; 8: 14977. Graff M et al. Genome-wide physical activity interactions in adiposity ? a meta-analysis of 200,452 adults. PLoS Genet. 2017 Aug 23;13(8):e1006972. Wheeler E et al. Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. PLoS Med. 2017 Sep 12;14(9): e1002383.
Start Year 2010
 
Description UCL Alcohol collaboration 
Organisation University College London
Department Research Department of Epidemiology and Public Health
Country United Kingdom 
Sector Academic/University 
PI Contribution Data analysis, expertise, contributing to papers
Collaborator Contribution Data analysis, expertise, contributing to papers
Impact Britton PMID:25858476 Britton PMID: 27473049
Start Year 2014
 
Description UCLA menopause/epigenetics 
Organisation University of California, Los Angeles (UCLA)
Country United States 
Sector Academic/University 
PI Contribution Provide NSHD data, expertise, analysis, contribution to research papers
Collaborator Contribution Provide expertise, analysis, contribution to research papers
Impact Levine 27457926. New project started on ageing with SH
Start Year 2015
 
Description UCLEB cohort collaboration for genetic research 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution NSHD data sharing and epideomiological experitise
Collaborator Contribution Maximising research potential of NSHD Prof Aroon Hinorani brings in CVD and genetic skills and manages the collaboration with several CVD cohort studies at UCL and Edinburgh, including NSHD. Data sharing
Impact UCL Biomedical Research Centre High Impact Grant awarded BHF programme grant under review 23977022 White 26781229 Neusch 25979724 Talmund 25475436 White 26781229 Beaney 27549350 Morris 27365493 Prins 27327646 Beaney KE. Functional analysis of the coronary heart disease risk locus on chromosome 21q22. PMID:28458444 PMC5387827 Dale C. Causal Associations of Adiposity and Body Fat Distribution with Coronary Heart Disease, Stroke Subtypes and Type 2 Diabetes: A Mendelian Randomization Analysis. PMID: 28500271 PMC5515354 Fairoozy R. Identifying Low Density Lipoprotein Cholesterol Associated Variants in the Annexin A2 (ANXA2) Gene. PMID:28456096 PMC5446264
Start Year 2008
 
Description UCLEB cohort collaboration for genetic research 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution NSHD data sharing and epideomiological experitise
Collaborator Contribution Maximising research potential of NSHD Prof Aroon Hinorani brings in CVD and genetic skills and manages the collaboration with several CVD cohort studies at UCL and Edinburgh, including NSHD. Data sharing
Impact UCL Biomedical Research Centre High Impact Grant awarded BHF programme grant under review 23977022 White 26781229 Neusch 25979724 Talmund 25475436 White 26781229 Beaney 27549350 Morris 27365493 Prins 27327646 Beaney KE. Functional analysis of the coronary heart disease risk locus on chromosome 21q22. PMID:28458444 PMC5387827 Dale C. Causal Associations of Adiposity and Body Fat Distribution with Coronary Heart Disease, Stroke Subtypes and Type 2 Diabetes: A Mendelian Randomization Analysis. PMID: 28500271 PMC5515354 Fairoozy R. Identifying Low Density Lipoprotein Cholesterol Associated Variants in the Annexin A2 (ANXA2) Gene. PMID:28456096 PMC5446264
Start Year 2008
 
Description UCLEB cohort collaboration for genetic research 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution NSHD data sharing and epideomiological experitise
Collaborator Contribution Maximising research potential of NSHD Prof Aroon Hinorani brings in CVD and genetic skills and manages the collaboration with several CVD cohort studies at UCL and Edinburgh, including NSHD. Data sharing
Impact UCL Biomedical Research Centre High Impact Grant awarded BHF programme grant under review 23977022 White 26781229 Neusch 25979724 Talmund 25475436 White 26781229 Beaney 27549350 Morris 27365493 Prins 27327646 Beaney KE. Functional analysis of the coronary heart disease risk locus on chromosome 21q22. PMID:28458444 PMC5387827 Dale C. Causal Associations of Adiposity and Body Fat Distribution with Coronary Heart Disease, Stroke Subtypes and Type 2 Diabetes: A Mendelian Randomization Analysis. PMID: 28500271 PMC5515354 Fairoozy R. Identifying Low Density Lipoprotein Cholesterol Associated Variants in the Annexin A2 (ANXA2) Gene. PMID:28456096 PMC5446264
Start Year 2008
 
Description UK Dementia Platform 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants.
Collaborator Contribution The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform.
Impact Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created
Start Year 2009
 
Description UK Dementia Platform 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants.
Collaborator Contribution The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform.
Impact Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created
Start Year 2009
 
Description UK Dementia Platform 
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants.
Collaborator Contribution The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform.
Impact Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created
Start Year 2009
 
Description UK Dementia Platform 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants.
Collaborator Contribution The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform.
Impact Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created
Start Year 2009
 
Description UK Dementia Platform 
Organisation Swansea University
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants.
Collaborator Contribution The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform.
Impact Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created
Start Year 2009
 
Description UK Dementia Platform 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants.
Collaborator Contribution The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform.
Impact Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created
Start Year 2009
 
Description UK Dementia Platform 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants.
Collaborator Contribution The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform.
Impact Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created
Start Year 2009
 
Description UK Dementia Platform 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants.
Collaborator Contribution The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform.
Impact Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created
Start Year 2009
 
Description UK Dementia Platform 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants.
Collaborator Contribution The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform.
Impact Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created
Start Year 2009
 
Description UK Dietary consortium 
Organisation Medical Research Council (MRC)
Department MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC)
Country United Kingdom 
Sector Public 
PI Contribution Provided data and input on manuscripts
Collaborator Contribution Provided evidence for/against the role of diet on cancer - results from this work informed LHA programme on lifetime lifestyleProvided data.Provided statistical advice.Provided data.Provided data and helped with the interpretation of results.Provided data on nutrition.
Impact 20437091 22127331 22139959 20407088 20702156 20648013 Lane: 27677361 Lane JA, Prostate cancer risk related to foods, food groups, macronutrients and micronutrients derived from the UK Dietary Cohort Consortium food diaries. PMID: 28294171 PMC5383924
Start Year 2007
 
Description UK Dietary consortium 
Organisation Medical Research Council (MRC)
Department MRC Human Nutrition Research Unit
Country United Kingdom 
Sector Public 
PI Contribution Provided data and input on manuscripts
Collaborator Contribution Provided evidence for/against the role of diet on cancer - results from this work informed LHA programme on lifetime lifestyleProvided data.Provided statistical advice.Provided data.Provided data and helped with the interpretation of results.Provided data on nutrition.
Impact 20437091 22127331 22139959 20407088 20702156 20648013 Lane: 27677361 Lane JA, Prostate cancer risk related to foods, food groups, macronutrients and micronutrients derived from the UK Dietary Cohort Consortium food diaries. PMID: 28294171 PMC5383924
Start Year 2007
 
Description UK Dietary consortium 
Organisation University College London
Department Institute of Epidemiology and Health Care
Country United Kingdom 
Sector Academic/University 
PI Contribution Provided data and input on manuscripts
Collaborator Contribution Provided evidence for/against the role of diet on cancer - results from this work informed LHA programme on lifetime lifestyleProvided data.Provided statistical advice.Provided data.Provided data and helped with the interpretation of results.Provided data on nutrition.
Impact 20437091 22127331 22139959 20407088 20702156 20648013 Lane: 27677361 Lane JA, Prostate cancer risk related to foods, food groups, macronutrients and micronutrients derived from the UK Dietary Cohort Consortium food diaries. PMID: 28294171 PMC5383924
Start Year 2007
 
Description UK Dietary consortium 
Organisation University of Cambridge
Department MRC Biostatistics Unit
Country United Kingdom 
Sector Public 
PI Contribution Provided data and input on manuscripts
Collaborator Contribution Provided evidence for/against the role of diet on cancer - results from this work informed LHA programme on lifetime lifestyleProvided data.Provided statistical advice.Provided data.Provided data and helped with the interpretation of results.Provided data on nutrition.
Impact 20437091 22127331 22139959 20407088 20702156 20648013 Lane: 27677361 Lane JA, Prostate cancer risk related to foods, food groups, macronutrients and micronutrients derived from the UK Dietary Cohort Consortium food diaries. PMID: 28294171 PMC5383924
Start Year 2007
 
Description UK Dietary consortium 
Organisation University of Leeds
Department Faculty of Medicine and Health
Country United Kingdom 
Sector Academic/University 
PI Contribution Provided data and input on manuscripts
Collaborator Contribution Provided evidence for/against the role of diet on cancer - results from this work informed LHA programme on lifetime lifestyleProvided data.Provided statistical advice.Provided data.Provided data and helped with the interpretation of results.Provided data on nutrition.
Impact 20437091 22127331 22139959 20407088 20702156 20648013 Lane: 27677361 Lane JA, Prostate cancer risk related to foods, food groups, macronutrients and micronutrients derived from the UK Dietary Cohort Consortium food diaries. PMID: 28294171 PMC5383924
Start Year 2007
 
Description UK Dietary consortium 
Organisation University of Oxford
Department Cancer Epidemiology Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution Provided data and input on manuscripts
Collaborator Contribution Provided evidence for/against the role of diet on cancer - results from this work informed LHA programme on lifetime lifestyleProvided data.Provided statistical advice.Provided data.Provided data and helped with the interpretation of results.Provided data on nutrition.
Impact 20437091 22127331 22139959 20407088 20702156 20648013 Lane: 27677361 Lane JA, Prostate cancer risk related to foods, food groups, macronutrients and micronutrients derived from the UK Dietary Cohort Consortium food diaries. PMID: 28294171 PMC5383924
Start Year 2007
 
Description University of Cambridge (NS) 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Provide expertise, analysis, contribution to research papers and other research activities
Collaborator Contribution Provide expertise, analysis, contribution to research papers and other research activities
Impact Ongoing collaboration before PI started at the Unit Motor recovery after subcortical stoke depends upon modulation of extant motor networks. PMID:26635715 Computed tomography perfusion can guide endovascular therapy in bilateral carotid artery dissection EJCRIM 2015;2:doi:10.12890/2015_000295
Start Year 2015
 
Description Vitamin D 
Organisation University College London
Department Institute of Child Health
Country United Kingdom 
Sector Academic/University 
PI Contribution We completed analysis on the genotyping that was done on NSHD study memebers
Collaborator Contribution The UCL group paid for genotyping of NSHD samples and carried out meta analysis in collaboration with a number of cohort studies
Impact Vimaleswaran et al PMID:24974252
Start Year 2011
 
Description 'Seize the day' Life experiences through dance. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Seize the Day is a unique patient and public engagement event developed in collaboration with researchers from UCL, Movement for Hope (UCL SME), and Tanztheater Adrian Look dance company. The art-science dance performance explores stories of unexpected disease onset and how it changes person's perspective. The dance shares a journey through diagnosis, challenges, triumphs and hope.

After the dance, there will be a question & answer session with researchers, dancers and patient-advocates
Year(s) Of Engagement Activity 2016
 
Description 72nd birthday card workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Two workshops were held with ~20 school students (year 9 and year 13) to discuss the history of cohort studies and why they are important. Students were then asked to design a birthday card for our study members using collage. They used old memorabilia from the study. This was a collaboration between a collage artist and two historians from LSHTM. A number of birthday cards were created and two were chosen to send to our study members. As a result of this collaboration a research paper about the history of the NSHD is in progress as well as another public engagement event.
Year(s) Of Engagement Activity 2017
 
Description Article in Leonard Wolfson Experimental Neurology Centre newsletter about MND early diagnostic clinic 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Article in Leonard Wolfson Experimental Neurology Centre newsletter about MND early diagnostic clinic. Raised awareness of this clinic and the benefits of early diagnosis of MND
Year(s) Of Engagement Activity 2016
 
Description Article on logitudinal studies in The Guardian 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact The Director was interviewed for an article about the importance of longitudinal studies

Increased awareness of NSHD and longitudinal studies research and the benefits of it
Year(s) Of Engagement Activity Pre-2006,2014
 
Description BBC breakfast news recording, BBC Radio 4 Piece and Telegraph article (print and online) about the neuroimaging clinical sub-study. 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Increased awareness of the NSHD and new neuroscience sub study. Resulted in 3 members of the study who had previously not bee in contact wishing to be involved again.
Year(s) Of Engagement Activity 2015
 
Description CLSA Webinar Series: Aging is a lifelong and socially patterned process 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact CLSA Webinar Series: Aging is a lifelong and socially patterned process. Increased awareness of NSHD research.
Year(s) Of Engagement Activity 2016
 
Description DELPHIC public debate 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Debate on management of cognitive impairment in acute hospitals. Purpose was to stimulate discussion on where priorities should be focussed. Impacts included raising profile of delirium as important issue in hospitals.
Year(s) Of Engagement Activity 2017
 
Description DK featured in an article by Der Spiegel 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact DK was interviewed by the newspaper to discussed the MRC NSHD and the findings of the research over the past 70 years.
Year(s) Of Engagement Activity 2016
 
Description DK featured in an article by the Daily Mail about how to age well 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Article specifically mentioned the NSHD so would have raised awareness of the cohort
Year(s) Of Engagement Activity 2016
 
Description DK interviewed for DPUK newsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The Director of NSHD was interviewed for the DPUK newsletter to discuss how she achieved her various academic successes, the route she took to becoming a Professor, and the training and support she received during her career.
Year(s) Of Engagement Activity 2016
 
Description DK spoke to BBC World in Action Radio Show about epigenetics and ageing 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact DK spoke to BBC World in Action Radio Show about epigenetics and ageing. Increased awareness of this topic and the use of cohorts in researching this area
Year(s) Of Engagement Activity 2016
 
Description Dementia UK blog post about special debate on how dementia and delirium should be approached in acute hospital settings 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Blog post was written about a debate which a LHA clinician took part in to raise awareness of dementia and delirium.
Year(s) Of Engagement Activity 2017
 
Description Dementia UK debate and blog post about delirium 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Dementia and delirium specialists from University College Hospital London, The Royal London Hospital and Dementia UK came together at the end of February for a special debate on how dementia and delirium should be approached in acute hospital settings. The event was organised by staff from University College Hospital and generated lots of interest.
Year(s) Of Engagement Activity 2017
URL https://www.dementiauk.org/dementia-or-delirium-so-what/
 
Description Diana Kuh attended the launch of the neuroimaging sub-study -Insight 46 hosted by Alzheimer's Research UK - took part in a panel discussion. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact The discussion was recorded in a podcast .Increased awareness of the NSHD and new neuroscience sub study. Increased donations to ARUK through presenting to major donors
Year(s) Of Engagement Activity 2015
 
Description Diana Kuh gave a presentation at the Islington University of the Third Age on 'A life course approach to healthy ageing'. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Increased awareness of NSHD and a life course approach to healthy ageing
Year(s) Of Engagement Activity 2015
 
Description Diana Kuh took part in a radio show - The Agenda - on Wireless Radio (in partnership with Age UK) to speak about the NSHD and the neuroimaging study. 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Increased awareness of the NSHD to a new audience who have an active interest in healthy ageing.
Year(s) Of Engagement Activity 2015
 
Description Generations Apart Film 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact Generations apart film was created by NSHD and ALSPAC. The film featured study members taking about their shared experience of being part of a cohort study. There was also a film screening as part of MRC Festival of Medical Research. Around 50-60 people were present and there was a positive Q and A session afterwards with Diana Kuh, Lynn Molloy and 2 study members.
Year(s) Of Engagement Activity 2016
 
Description Green Man Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Green Man Festival. Scientists from the Medical Research Council Unit for Lifelong Health and Ageing at UCL wanted to tell people all about their work- a UK birth cohort study of 5000 people who have been studied by the unit ever since they were born in 1946.

Funded by the Wellcome Trust, artists helped to transform the study into 'Tangle', an activity designed to represent how scientists gather up the threads of many people's lives and weave them together to answer research questions. Festival goers were asked to contribute their data on eight variables the scientists examine, for example stress, memory, and health behaviours. Instead of filling out questionnaires, the participants got a piece of coloured fabric for each of their answers, which they wound onto a rope to create their "life course". Anything else that they thought was important in their lives they wrote onto a fabric luggage tag to share with everyone.

More than 600 people came to talk to the scientists and make their own life course, which they then used to help answer a research question: "What is most important to your quality of life." Against the backdrop of Welsh mountains a tapestry frame stood displaying various answers such as, "health", "wealth" and "music" (well, it was a music festival). The new study members threaded their own life course into the section that represented them. It soon became obvious what was most important to their quality of life.
Year(s) Of Engagement Activity 2017
 
Description HALCYon Project Summary Brochure 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact A plain english brochure was created which summarised the main findings from the HALCyon research programme. It has been disseminated to study members, on our website and the New Dynamics of Ageing website and at conferences.

Increased awareness of the findings from the HALCyon programme and the cohorts that were used within this research programme
Year(s) Of Engagement Activity 2014
 
Description HALCYon book launch 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact A book launch was arranged to promote the findings from the HALCyon research programme

Shared knowledge of the HALCyon findings which were published in a book 'A life course approach to healthy ageing'.
Year(s) Of Engagement Activity 2014
 
Description Leyden Academy visit 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact Talks were given by LHA researcher to visiting health professionals who were on a course run by the Leyden Academy in the Netherlands

Increased awareness of the work of the Unit for Lifelong Health and Ageing and longitudinal studies
Year(s) Of Engagement Activity 2014
 
Description Luigi Ferrucci Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Health professionals
Results and Impact A lecture was organised that sparked questions and discussions afterwards

Increased awareness of ageing research, enhanced the relationship with the invited speaker
Year(s) Of Engagement Activity 2014
 
Description MRC Festival of Medical Research Exhibition 70 years of... 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact The activty showcased the history of the cohorts birthday cards as well as old letters from the study and how data used to be presented. The work was presented in a gallery space in collaboration with an art student from the Univerisyt of the arts as well as the president of the UCL medical and arts society. The idea was to create an art exhibition using historical items from the study
Year(s) Of Engagement Activity 2017
 
Description Media interest in 'Smoking induces early signs of cancer in cheek swabs'. 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Increased awareness of NSHD research
Year(s) Of Engagement Activity 2015
 
Description NDA Closing Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The Unit took part in the NDA Closing Conference and had a stand explaining the findings from the HALCyon Study.

Director also gave a presentation
The NDA HALCyon research programme:
Key findings and implications
Diana Kuh
MRC Unit for Lifelong Health and Ageing
on behalf of the HALCyon study team
NDA Final Conference
London, 21st October 2013


Chance to disseminate HALCyon findings to health professionals, local community groups and the general public
Year(s) Of Engagement Activity 2013
 
Description NDA findings brochure 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The New Dynamics of Ageing programme which funded the HALCyon programme created a findings document summerising the results of the HALCyon programme which was distributed to their local networks

Increased awareness of the HALCyon findings and a life course approach to healthy ageing. Increased awareness of longitudinal studies and the cohorts that were involved in HALCyon
Year(s) Of Engagement Activity 2014
 
Description NS interviewed by BBC Breakfast News to discuss the first Early Diagnostic Clinic 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact NS was interviewed by BBC Breakfast News to discuss the first Early Diagnostic Clinic which he created at the National Hospital for Neurology and Neurosurgery. Raised awareness of MND, the new clinic and the importance of early diagnosis
Year(s) Of Engagement Activity 2016
 
Description NSHD 70th birthday events and media interest 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact The department organised two birthday events for our study members in London and Manchester. The parties gained significant media attention (print and feature on BBC news). The study member feedback was also very positive and the events were seen as a success.

Health Study - why we owe so much to the class of '46, The Observer
BBC News at 10, Tuesday 1st March
BBC Breakfast short version, Wednesday 2nd March
BBC Inside Science, Thursday 3rd March
The Naked Scientists, Monday 7th March
A video of the London event was created by Dreaming Fish on behalf of the MRC.
The NSHD also featured on a number of local BBC radio stations on Wednesday 1st March.
BBC Radio Cambridgeshire
MRC Network Magazine
MRC Life Magazine
MRC Sound Cloud https://soundcloud.com/the_mrc/mrc-talks-episode-7
Sunday People http://www.mirror.co.uk/news/uk-news/douglas-babies-who-helped-shape-7634768
http://news.xinhuanet.com/english/2016-03/05/c_135159132.htm
Study member interviewed on Radio Stoke 4 March 2016 14:26
Year(s) Of Engagement Activity 2016
 
Description NSHD 70th birthday press coverage 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Media interest in the 70th birthday events for the NSHD and coverage of Helen Pearson's book on UK cohorts - The Life Project
Articles and features in/on The Independent, The Sunday Times, The Evening Standard, BBC Breakfast News, BBC News at 10, Inside Science, Local BBC radio stations.
Year(s) Of Engagement Activity 2016
 
Description New story on MRC website about Einstein's garden at Green Man Festival 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact News story on the MRC public engagement section of their website detailing the activity we took part in for the Green Man Festival
Year(s) Of Engagement Activity 2017
 
Description Open meeting at St John and Elizabeth Hospice with MND patients - talk and Q and A session 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact Open meeting at St John and Elizabeth Hospice with MND patients - talk and Q and A session. Information shared about MND.
Year(s) Of Engagement Activity 2016
 
Description Presentation at the Danish Society for Psychosocial Medicine 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Director invited to give a presentation at the Danish Society for Psychosocial Medicine.

Does the life course approach provide new knowledge and how can we use it?
Professor Diana Kuh, MRC Unit for Lifelong Health and Ageing
Danish Society for Psychosocial Medicine
Copenhagen, November 14th 2013


Promotion of life course approach to healthy ageing
Year(s) Of Engagement Activity 2013
 
Description Press interest in Daniel Swerdlow paper 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact press interest in research paper that sued NSHD data about the benefits of statins

Increased awareness about the benefit of statins
Year(s) Of Engagement Activity 2014
 
Description Press interest in Martin Widschwendter breast cancer paper 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Press interest in research paper about breast cancer

Increase awareness of the stuudies findings
Year(s) Of Engagement Activity 2014
 
Description Press interest in hormones and socioeconomic conditions paper 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Press interest in article about hormones and socioeconomic conditions. The Telegraph published an article on this. Increased awareness of NSHD research.
Year(s) Of Engagement Activity 2015
 
Description Press release about IOE merger 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Press release about the merger of IOE which mention the fact that UCL now houses a number of birth cohorts including the NSHD
Year(s) Of Engagement Activity 2015
 
Description Press release about delirium paper 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Press release about a research paper about delirium. Increased awareness about delirium.
Year(s) Of Engagement Activity 2017
 
Description Press release about healthy migrant hypothesis 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Press release about the paper - An investigation of the healthy migrant hypothesis: Pre-emigration characteristics of those in the British 1946 birth cohort study. Increased awareness about the NSHD research
Year(s) Of Engagement Activity 2016
 
Description Press release about menopause Interlace 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Press release about a piece of research about starting menstrual periods at a young age increases risk of premature and early menopause
Year(s) Of Engagement Activity 2017
 
Description Press release and Stand about delirium for 'Say Delirium' week 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Press release about how staff at the Royal Free Hospital are urging fellow staff, patients and carers to 'Say delirium' this week (13 - 19 March), in order to raise awareness of this serious condition. There was a stand in the main reception of the Royal Free to raise awareness of the condition with staff and patients and also to promote the DELPHIC study lead by a LHA researcher.
Year(s) Of Engagement Activity 2017
 
Description Public Lecture by Kenneth Rockwood, 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Public lecture by Kenneth Rockwood, Professor of Geriatric Medicine at Dalhousie University titled: Does it matter that dementia is mostly a problem of older people?"
Year(s) Of Engagement Activity 2015
 
Description Rewired talk 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact NS took part in Rewired which is an event which aims to raise public awareness of neurological conditions using artistic collaborations and cutting-edge research.
Year(s) Of Engagement Activity 2017
 
Description Talk to Year 10 students from Westminster Academy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Nik Sharma spoke to a group of year 10's from Westminster Academy as part of the UCLH/Biomedical Research Centre open day. The topic was 'what is research and the career of a researcher' and the talk sparked questions and discussions afterwards.
Year(s) Of Engagement Activity 2015
 
Description Ted Talk by Helen Pearson about The Life Project 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Scientists at the Unit contributed to Helen Pearson's book 'The Life Project'. Helen gave a talk featureing the NSHD for TED. It has had 1,649,889 views and has increased the awareness of the NSHD and longitudinal research.
Year(s) Of Engagement Activity 2017
URL https://www.ted.com/talks/helen_pearson_lessons_from_the_longest_study_on_human_development
 
Description Took part in Cheltenham Science Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact DK took part in a Cheltenham Science Festival event with a study member and Helen Pearson to talk about the Life Project book and the work of the NSHD. Raised awareness of NSHD research.
Year(s) Of Engagement Activity 2016
 
Description Twitter account created for MRC LHA 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact A twitter account was created for MRC LHA to coincide with the 70th birthday events. We have a number of followers and are working to increase this and promote NSHD research on the account.
Year(s) Of Engagement Activity 2016
 
Description Two week student visit at MRC LHA (NS) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Two week sixth form visit to the Unit as part of (http://in2scienceuk.org). in2scienceUK is an award winning organisation which gives students from low income backgrounds the opportunity to work alongside STEM scientists, and receive the advice and information they need to progress to University and STEM careers.
Year(s) Of Engagement Activity 2015
 
Description UCL Ageing Festival Event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact The Director was part of a discussion panel at a UCL Ageing Festival Event
An UCL/International Longevity Centre-UK discussion Working Longer in an Ageing Society
Brian Beach (ILC-UK), Prof Diana Kuh (UCL), Ms Jenny Head (UCL), Ms Katherine Wilson, Carers UK

Increase awareness of the benefit of using longitudinal studies to study ageing
Year(s) Of Engagement Activity 2013
 
Description Updating BMA Growing Up in the UK Report Update 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Diana Kuh contributed to BMA Growing Up in the UK Report Update and made recommendations.
Four main recommendations require action beyond individual behaviour, that is at national level, to address the broader social and economic drivers influencing early environments and possible remedial actions.
Year(s) Of Engagement Activity 2016
 
Description Webinar for motor neurone disease week 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact Webinar for Motor Neurone Disease week - Nik Sharma and Jan Clarke (MND Specialist Nurse). Suggestions for topics requested from the public.
Year(s) Of Engagement Activity 2015
URL https://www.uclh.nhs.uk/aboutus/webchat/Pages/AskanexpertMotorNeuroneDisease.aspx
 
Description Website media interest in 'Childhood socioeconomic position and adult leisure-time physical activity: a systematic review' 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Paper sparked comments on discussion board
Increased awareness of NSHD research
Year(s) Of Engagement Activity 2015