China Kadoorie Biobank (CKB) prospective study of 0.5 million adults
Lead Research Organisation:
University of Oxford
Abstract
Chronic diseases, such as stroke, heart disease, and cancer, are the leading causes of disability and death worldwide. Understanding what causes these diseases in different populations can lead to improvements in disease prevention, risk prediction and development of new treatments. One way of identifying causes of disease is through blood-based “prospective cohort” studies, in which large numbers of apparently healthy individuals from the general population are interviewed and measured, and have blood collected and tested for genetic and non-genetic biomarkers. The health status of the study participants is then monitored “prospectively” to see who develops what disease. When sufficiently large numbers of people have developed a particular disease (“cases”), their blood and other characteristics are compared with those from “controls” who have not developed the disease. We have established one of the world’s largest studies of this kind, involving 512,000 adults in China. Ongoing follow-up work ensures that disease outcomes are correctly identified, checked and carefully classified before the data is analysed by researchers. We are also expanding the use of this valuable resource by the wider research community, so that many important new findings will emerge which will enable better disease prevention and treatment, benefiting populations worldwide.
Technical Summary
China Kadoorie Biobank is a blood-based prospective study of 512,000 adults, recruited during 2004-8 from 10 diverse regions of China, with extensive data collected at baseline and subsequent resurveys using questionnaires, physical measurements, and stored biological samples.
Chronic diseases are major causes of death and disability in China and worldwide. Large-scale prospective studies of multiple risk factors, with blood storage for testing novel hypotheses and detailed follow-up of health outcomes, will help assess the causes of chronic diseases. Studies in China, given the special patterns of exposures and diseases, will yield novel findings, complementing similar studies elsewhere (e.g. UK Biobank). The CKB will improve understanding of disease aetiology, risk prediction and the development of new therapies, benefitting populations worldwide.
By Q4 2016, follow-up through linkage to death and disease registries and to nationwide health insurance databases of all hospitalised events has accumulated 0.5 million hospitalised events and 35,500 deaths among CKB participants, including incident cases of stroke (42,000), IHD (35,000), cancer (23,000), diabetes (13,500) and COPD (9,500). Only ~4,000 (<1%) participants were lost to follow-up. Genome-wide data are being generated (first phase: ~100,000 participants by Q3/2016), along with blood biochemistry and multi-omics data for nested case-control studies of specific diseases.
CKB will prioritise (i) continued follow-up of cause-specific morbidity and mortality and hospital records through electronic linkage to health insurance systems; (ii) validation, clinical adjudication and detailed sub-phenotyping for selected diseases (e.g. stroke, IHD, cancer); (iii) maintenance and management of extensive and uniquely large and complex datasets; (iv) enhancement of collaboration and data sharing with the wider scientific community.
Future research based on data and samples collected to date is likely to lead to the identification of novel genetic and blood-based biomarkers involved in various chronic diseases. These can help develop improved algorithms for disease risk prediction. Biomarkers associated with early onset and/or progression of disease may also be used for early diagnosis and prediction of prognosis. Improved understanding of disease pathways and mechanisms may lead to the identification of novel therapeutic and pharmacogenetic targets that may be patentable or commercially exploitable.
Health insurance data already collected (2006-2016), includes 600,000 coded hospitalised disease events of many different types and 60 million in-hospital treatment, test and procedures-related data. Analysis of this will help evaluate the delivery of effective healthcare by quantifying over-hospitalization and inappropriate use of investigative procedures and treatments for common causes of hospitalizations.
Chronic diseases are major causes of death and disability in China and worldwide. Large-scale prospective studies of multiple risk factors, with blood storage for testing novel hypotheses and detailed follow-up of health outcomes, will help assess the causes of chronic diseases. Studies in China, given the special patterns of exposures and diseases, will yield novel findings, complementing similar studies elsewhere (e.g. UK Biobank). The CKB will improve understanding of disease aetiology, risk prediction and the development of new therapies, benefitting populations worldwide.
By Q4 2016, follow-up through linkage to death and disease registries and to nationwide health insurance databases of all hospitalised events has accumulated 0.5 million hospitalised events and 35,500 deaths among CKB participants, including incident cases of stroke (42,000), IHD (35,000), cancer (23,000), diabetes (13,500) and COPD (9,500). Only ~4,000 (<1%) participants were lost to follow-up. Genome-wide data are being generated (first phase: ~100,000 participants by Q3/2016), along with blood biochemistry and multi-omics data for nested case-control studies of specific diseases.
CKB will prioritise (i) continued follow-up of cause-specific morbidity and mortality and hospital records through electronic linkage to health insurance systems; (ii) validation, clinical adjudication and detailed sub-phenotyping for selected diseases (e.g. stroke, IHD, cancer); (iii) maintenance and management of extensive and uniquely large and complex datasets; (iv) enhancement of collaboration and data sharing with the wider scientific community.
Future research based on data and samples collected to date is likely to lead to the identification of novel genetic and blood-based biomarkers involved in various chronic diseases. These can help develop improved algorithms for disease risk prediction. Biomarkers associated with early onset and/or progression of disease may also be used for early diagnosis and prediction of prognosis. Improved understanding of disease pathways and mechanisms may lead to the identification of novel therapeutic and pharmacogenetic targets that may be patentable or commercially exploitable.
Health insurance data already collected (2006-2016), includes 600,000 coded hospitalised disease events of many different types and 60 million in-hospital treatment, test and procedures-related data. Analysis of this will help evaluate the delivery of effective healthcare by quantifying over-hospitalization and inappropriate use of investigative procedures and treatments for common causes of hospitalizations.
Organisations
- University of Oxford, United Kingdom (Collaboration, Lead Research Organisation)
- Global Lipids Genetic Consortium (GLGC) (Collaboration)
- University College London, United Kingdom (Collaboration)
- ReproGen Consortium (Collaboration)
- University of Edinburgh, United Kingdom (Collaboration)
- UK Biobank, United Kingdom (Collaboration)
- Beijing Genomics Institute (BGI) (Collaboration)
- Chinese University of Hong Kong (Collaboration)
- Social Science Genetics Association Consortium (Collaboration)
- Chinese Academy of Sciences (Collaboration)
- University of Cambridge (Collaboration)
- Nanjing Medical University (Collaboration)
- Massachusetts General Hospital (Collaboration)
- Bayer (Collaboration)
- University of Hong Kong, Hong Kong (Collaboration)
- University of Bristol, United Kingdom (Collaboration)
- Imperial College London, United Kingdom (Collaboration)
- Peking University, China (Collaboration)
- Nightingale Health Ltd. (Collaboration)
- Broad Institute (Collaboration)
- University of Colorado at Boulder, United States (Collaboration)
- University of Oulu, Finland (Collaboration)
- McGill University, Canada (Collaboration)
- University of North Carolina at Chapel Hill (Collaboration)
- Fudan University (Collaboration)
- International Agency for Research on Cancer (IARC) (Collaboration)
- Lund University (Collaboration)
- German Cancer Research Center (Collaboration)
- George Institute for Global Health (Collaboration)
- University of Leicester, United Kingdom (Collaboration)
People |
ORCID iD |
Zhengming Chen (Principal Investigator) |
Publications


Arnold M
(2019)
Carotid Intima-Media Thickness but Not Carotid Artery Plaque in Healthy Individuals Is Linked to Lean Body Mass.
in Journal of the American Heart Association

Bakker MK
(2020)
Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors.
in Nature genetics

Bennett DA
(2019)
Physical activity, sedentary leisure-time and risk of incident type 2 diabetes: a prospective study of 512 000 Chinese adults.
in BMJ open diabetes research & care

Bennett DA
(2017)
Association of Physical Activity With Risk of Major Cardiovascular Diseases in Chinese Men and Women.
in JAMA cardiology

Bennett DA
(2017)
Systematic review of statistical approaches to quantify, or correct for, measurement error in a continuous exposure in nutritional epidemiology.
in BMC medical research methodology

Bovijn J
(2020)
Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics.
in Science translational medicine

Bovijn J
(2020)
Genetic variants mimicking therapeutic inhibition of IL-6 receptor signaling and risk of COVID-19
in The Lancet Rheumatology


Bragg F
(2018)
Associations of General and Central Adiposity With Incident Diabetes in Chinese Men and Women.
in Diabetes care
Description | BHF Centre for Research Excellence |
Amount | £198,595 (GBP) |
Organisation | British Heart Foundation (BHF) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 11/2016 |
End | 10/2018 |
Description | CRUK Project Grant |
Amount | £294,057 (GBP) |
Organisation | Cancer Research UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 11/2017 |
End | 10/2020 |
Description | Diet, biomarkers and non-communicable diseases in rural and urban China: federated analysis of population-based studies |
Amount | £32,052 (GBP) |
Funding ID | MR/T008547/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 07/2019 |
End | 04/2020 |
Description | Future of Animal-sourced Foods (FOAF) |
Amount | £4,391,572 (GBP) |
Funding ID | 205212/Z/16/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2017 |
End | 05/2021 |
Description | Improving cancer prevention, risk-stratification, and detection using large-scale prospective studies in diverse populations |
Amount | £10,521,580 (GBP) |
Funding ID | C16077/A29186 |
Organisation | Cancer Research UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2020 |
End | 03/2025 |
Description | Intermediate Clinical Research Fellowship |
Amount | £1,027,000 (GBP) |
Funding ID | FS/18/23/33512 |
Organisation | British Heart Foundation (BHF) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 06/2018 |
End | 06/2023 |
Description | Medical Research Council Research Grant |
Amount | £185,000 (GBP) |
Funding ID | MR/S014551/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 11/2018 |
End | 04/2020 |
Description | The evaluation of effective healthcare delivery in China using electronic medical records for 10 years in 0.5M participants in the China Kadoorie Biobank |
Amount | £95,184 (GBP) |
Funding ID | 208126/Z/17/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2017 |
End | 10/2020 |
Description | Visiting Research Fellowship Programme for the China Kadoorie Biobank |
Amount | £50,800 (GBP) |
Organisation | Sino-British Fellowship Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 05/2017 |
End | 06/2022 |
Description | Wellcome Longitudinal Population Studies Grant |
Amount | £6,760,000 (GBP) |
Funding ID | 212946/Z/18/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2018 |
End | 08/2023 |
Title | China Kadoorie Biobank - Research Database |
Description | China Kadoorie Biobank (CKB) is a blood-based prospective cohort study of 512,000 adults, recruited from 10 diverse areas across China (during 2004-08), with extensive data collection at baseline and subsequent resurveys and long-term storage of biological samples. These exposure and outcome data are complemented by separately funded genotyping (currently for 102,000 participants), whole genome sequencing, and conventional and multi-omics assays for nested case-control studies of specific diseases. |
Type Of Material | Database/Collection of data |
Year Produced | 2015 |
Provided To Others? | Yes |
Impact | Group staff and collaborating institution have published over 300 papers using the CKB database. Since opening CKB data up for open access in September 2015, over 700 researchers have registered on the CKB Data Access System. By 18 February 2020, 352 new applications for datasets have been registered including 175 from open access users. |
URL | https://www.ckbiobank.org/site/Data+Access |
Description | Assessing health risks associated with exposure to household and ambient air pollution in rural and urban China |
Organisation | Fudan University |
Department | School of Public Health |
Country | China |
Sector | Academic/University |
PI Contribution | Development and execution of the project "Assessing health risks associated with exposure to household and ambient air pollution in rural and urban China" |
Collaborator Contribution | Provision of access to additional relevant datasets on air pollution and analytical support. |
Impact | Field data collected. Visiting researcher visiting oxford for data integration and analysis. |
Start Year | 2017 |
Description | BDI |
Organisation | University of Oxford |
Department | Big Data Institute |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Analyses of CKB data conducted according to group protocols and summary results supplied. |
Collaborator Contribution | Development of Anlaysis protocol for GWAS for miscarriage. |
Impact | GWAS of miscarriage traits complete, results supplied, published in Nature Communications 2020, PMID: 33239672 |
Start Year | 2017 |
Description | Bayer - CKB Collaborative Research Programme |
Organisation | Bayer |
Country | Germany |
Sector | Private |
PI Contribution | Joint initiative to: Investigation of chymase gene variants in CKB; reformat plasma samples for future multiomics assays ; conduct analyses of pilot proteomics data; perform quality control and characterisation of ~80,000 putative loss-of-function, missense, or other functionally-significant variants; develop phenome-wide and bioinformatics analyses pipelines for future work. |
Collaborator Contribution | Selection of variants of interest w.r.t drug targets; review of ongoing progress; |
Impact | Initial results for Chymase investigation in CKB; selection of CKB samples for reformatting from freezer storage initiated. |
Start Year | 2019 |
Description | Beijing Genomics Institute |
Organisation | Beijing Genomics Institute |
Country | China |
Sector | Academic/University |
PI Contribution | In kind contributions to assay costs for various DNA projects. CKB are working with BGI on various research projects including DNA extraction and large-scale GWAS of 100,000 CKB samples. We are also collaborating with BGI's Research organisation on a Mitochondrial DNA Project. This Project involves a pilot project of high-coverage sequencing of the mitochondrial genomes of up to 100 parent-offspring trios (300 samples) from the China Kadoorie Biobank, followed by the main project of sequencing of 15,000 additional samples. These results can be used to assess the inheritance patterns of mitochondrial genomes, including the extent of heteroplasmy and paternal inheritance. Also conducting whole-genome sequencing of 10,000 samples from the China Kadoorie Biobank. The results of this project can be used to construct sequencing reference panels for imputation of genetic variants in individuals of Chinese ancestry, to assess the quality of genome-wide genotyping data, to investigate human population diversity, both within China and globally, and to identify novel genetic variants of potential relevance to human disease. Assisting with a Replication of BMI and height associations from low-coverage NGS association analyses. Framework agreements for the above projects and future research collaborations ( eg on methylation, microbiome DNA) have been agreed and are awaiting signature. Also conducting whole-genome sequencing of 10,000 samples from the China Kadoorie Biobank. The results of this project can be used to construct sequencing reference panels for imputation of genetic variants in individuals of Chinese ancestry, to assess the quality of genome-wide genotyping data, to investigate human population diversity, both within China and globally, and to identify novel genetic variants of potential relevance to human disease. Assisting with a Replication of BMI and height associations from low-coverage NGS association analyses. Framework agreements for the above projects and future research collaborations ( eg on methylation, microbiome DNA) have been agreed and being finalised |
Collaborator Contribution | BGI are providing the facilities and technical infrastructure for the conduct of genomic assays including data handling and shared analysis |
Impact | Large scale GWAS of 100,000 CKB samples complete data available for analysis. Lookup of GWAS association for ~1900 SNPs provided. Manuscript published in Cell for BMI and height GWAS Whole Genome Sequencing of 10,000k CKB Sample underway. |
Start Year | 2015 |
Description | Broad Institute |
Organisation | Broad Institute |
Country | United States |
Sector | Charity/Non Profit |
PI Contribution | Sitting/standing height ratio GWAS |
Collaborator Contribution | Sitting/standing height ratio GWAS |
Impact | Analysis plan complete. Summary statistics for 4 traits, 100k individuals supplied, initial analyses complete. Supplementary analyses in progress |
Start Year | 2018 |
Description | Cambridge Cardiology |
Organisation | University of Cambridge |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Metaanalysis of NMR metabolomics GWAS |
Collaborator Contribution | Metaanalysis of NMR metabolomics GWAS |
Impact | NMR metabolomics GWAS complete, data supplied |
Start Year | 2019 |
Description | China Kadoorie Built Environment Urban Morphometric Platform |
Organisation | University of Hong Kong |
Country | Hong Kong |
Sector | Academic/University |
PI Contribution | Co-development of CKBUMP: China Kadoorie Built Environment Urban Morphometric Platform. To investigate a range of environmental exposures and their impact on health. CKB to provide health outcomes from Biobank participants. |
Collaborator Contribution | Co-development of CKBUMP: China Kadoorie Built Environment Urban Morphometric Platform. To investigate a range of environmental exposures and their impact on health. HK to provide expertise in geocoding and development of environmental exposure metrics. |
Impact | Work programme being developed, funding being sought. |
Start Year | 2017 |
Description | Chinese Academy of Sciences: Health Effects of fatty acids and irons |
Organisation | Chinese Academy of Sciences |
Department | Institute for Nutritional Sciences |
Country | China |
Sector | Learned Society |
PI Contribution | Established a large research project on dietary/environmental determinants and health effects of fatty acids and ions, based on CKB. This project has received major funding support from Chinese Academy of Sciences' Innovation fund to measure a whole range of fatty acid profile in erythrocyte membrane (n=10,000), ionomic profile in urine samples, as well as Hb1Ac among 25,000 resurvey participants. |
Collaborator Contribution | SIBS will conduct assays on samples from the China Kadoorie Biobank (CKB), including 25,000 urine and 25,000 blood red cell samples collected at the second resurvey. Red cell samples will be reformatted, and fatty acids (30 in total) assays will be conducted among the first 10,000 samples and HbA1c assays will be conducted among the total of 25,000 samples. Urine samples will be reformatted and ionomic (29 in total) and creatinine assays will be conducted. |
Impact | sample datasets being generated |
Start Year | 2016 |
Description | Comprehensive assessment of H. pylori antigens and other infectious pathogens in the aetiology of gastric and oesophageal cancer subtypes |
Organisation | German Cancer Research Center |
Country | Germany |
Sector | Academic/University |
PI Contribution | Guidance and collaborative development of research project "Comprehensive assessment of H. pylori antigens and other infectious pathogens in the aetiology of gastric and oesophageal cancer subtypes" |
Collaborator Contribution | Collaborative development of research project "Comprehensive assessment of H. pylori antigens and other infectious pathogens in the aetiology of gastric and oesophageal cancer subtypes" |
Impact | Project funded by CRUK, Serology data generated and shared, Joint analyses ongoing. |
Start Year | 2017 |
Description | Comprehensive assessment of H. pylori antigens and other infectious pathogens in the aetiology of gastric and oesophageal cancer subtypes |
Organisation | International Agency for Research on Cancer (IARC) |
Country | France |
Sector | Academic/University |
PI Contribution | Guidance and collaborative development of research project "Comprehensive assessment of H. pylori antigens and other infectious pathogens in the aetiology of gastric and oesophageal cancer subtypes" |
Collaborator Contribution | Collaborative development of research project "Comprehensive assessment of H. pylori antigens and other infectious pathogens in the aetiology of gastric and oesophageal cancer subtypes" |
Impact | Project funded by CRUK, Serology data generated and shared, Joint analyses ongoing. |
Start Year | 2017 |
Description | Fudan University |
Organisation | Fudan University |
Country | China |
Sector | Academic/University |
PI Contribution | Development and execution of the project "Assessing health risks associated with exposure to household and ambient air pollution in rural and urban China" |
Collaborator Contribution | Provision of access to additional relevant datasets on air pollution and analytical support |
Impact | Field data collected, currently being analysed. |
Start Year | 2014 |
Description | Fudan University - CKB Air |
Organisation | Fudan University |
Department | School of Public Health |
Country | China |
Sector | Academic/University |
PI Contribution | Working closely with the CKB group in China and Oxford to develop a joint research project on health effects of air-pollution based on the CKB study population. This project, named as CKB-Air, has now received major funding support from Chinese government. By linking CKB participants' unique national ID number and geo-coding to local air quality monitoring data and hospitalisation data it should generate a huge amount of additional data that can then be incorporated into main CKB database for research use. Fudan has access to air quality data. |
Collaborator Contribution | See above |
Impact | Collaboration lead to the development of a project proposal which has received funding from the MRC Global Challenges Research Fund . project called "Assessing health risks associated with exposure to household and ambient air pollution in rural and urban China" |
Start Year | 2016 |
Description | GIANT: Genetic Investigation of ANthropometric Traits |
Organisation | Broad Institute |
Department | The Genetic Investigation of ANthropometric Traits (GIANT) |
Country | United States |
Sector | Academic/University |
PI Contribution | GWAS Data for ~28k subjects supplied to assist various meta analyses being conducted by this group. CKB involved in convening the trans-ethnic analysis sub-group. |
Collaborator Contribution | Large meta-analysis of Height, BMI, WHR, WHRadjBMI; Joint / consortium publications |
Impact | papers under preparation |
Start Year | 2017 |
Description | GLGC |
Organisation | Global Lipids Genetic Consortium (GLGC) |
Country | United States |
Sector | Charity/Non Profit |
PI Contribution | GWAS Data for ~18k subjects supplied to assist various meta analyses being conducted by this group. |
Collaborator Contribution | Large meta-analysis of TC, LDL-c, HDL-c, TG |
Impact | Metaanalysis complete, first manuscript to be submitted soon |
Start Year | 2017 |
Description | GWAS & Sequencing Consortium of Alcohol and Nicotine |
Organisation | University of Colorado |
Country | United States |
Sector | Academic/University |
PI Contribution | GWAS of smoking, alcohol, U Colorado, for the GENESCAN consortium |
Collaborator Contribution | GWAS results supplied. Metanalysis ongoing |
Impact | Summary statistics supplied, paper in preparation |
Start Year | 2018 |
Description | George Institute for Global Health |
Organisation | George Institute for Global Health |
Country | Australia |
Sector | Academic/University |
PI Contribution | CKB team have provided access to data and advised on drafts of several papers considering the relationships between women's reproductive factors (such as number of pregnancies and age at menarche) and adiposity, incident cardiovascular disease and diabetes. Further collaboration on reproductive factors and hip factors. |
Collaborator Contribution | Two George Institute staff have dedicated significant time to analysis of results and drafting of papers |
Impact | Seven peer reviewed papers have been published to date. |
Start Year | 2015 |
Description | Imperial College London |
Organisation | Imperial College London |
Department | Department of Epidemiology and Biostatistics |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Provision of relevant baseline from CKB to contribute to the Non-Communicable Disease (NCD) Risk Factor Collaboration funded by the Wellcome Trust. |
Collaborator Contribution | Providing estimates of country/regional trends in major cardio-metabolic risk factors for non-communicable diseases (NCDs), globally; these include body mass index, cholesterol, blood pressure and glucose. |
Impact | Papers under preparation |
Start Year | 2017 |
Description | International Stroke Genetics Consortium |
Organisation | Massachusetts General Hospital |
Department | International Stroke Genetics Consortium |
Country | United States |
Sector | Hospitals |
PI Contribution | CKB plans to share genomics data or contribute to GWAS meta-analyses being conducted by this group. Summary statistics have been shared for GWAS of: (i) sub-arachnoid haemorrhage/ unruptured intracranial aneurysm; (ii) incident all stroke; (iii) fatal stroke, and mortality of incident stroke. Results of other analyses will only be shared after publication of CKB specific stroke genetics paper. |
Collaborator Contribution | Long-term collaboration. Access to additional GWAS data to increase the likelihood of novel significant findings. |
Impact | In Progress |
Start Year | 2016 |
Description | Lund University: Pancreatic Cancer |
Organisation | Lund University |
Department | Department of Immunotechnology |
Country | Sweden |
Sector | Hospitals |
PI Contribution | Access to CKB samples as part of a case control study. Including details metabolomic and proteomic profiling. |
Collaborator Contribution | Proteomic Assays, joint analysis of results. |
Impact | Subset measured, no promising signals in initial analysis conducted by Lund. Lund decided not to measure further samples. |
Start Year | 2016 |
Description | McGill University |
Organisation | McGill University |
Department | Genetic Epidemiology Richards Lab |
Country | Canada |
Sector | Academic/University |
PI Contribution | Validation of genetic risk score for bone mineral density |
Collaborator Contribution | List of variants and weights supplied. |
Impact | Association results from up to 102K individuals for a BMD risk score with BMD and endpoints, published in Genome Medicine 2021, PMID: 33536041 |
Start Year | 2018 |
Description | Nanjing Medical University |
Organisation | Nanjing Medical University |
Country | China |
Sector | Academic/University |
PI Contribution | Access to data resulting from genotyping. |
Collaborator Contribution | Contributing research and analystical expertise. CKB/ Oxford hosted a post-doctoral researcher from Nanjing who is continuing to work on this project since his return. |
Impact | Papers currently being drafted. |
Start Year | 2015 |
Description | Nightingale Health, Finland |
Organisation | Nightingale Health Ltd. |
Country | Finland |
Sector | Private |
PI Contribution | Metaanalysis of SNPs and gene-specific GRSs with lipid/NMR data. Results sent for 13 SNPs, 3 GRSs, 228 traits, up to 17k samples. |
Collaborator Contribution | academic partnership |
Impact | Paper published in Circulation |
Start Year | 2018 |
Description | Peking University PKU |
Organisation | Peking University |
Country | China |
Sector | Academic/University |
PI Contribution | Replication of fingerprint GWAS. Lookup of GWAS association for 118 SNPs with 20 fingerprint features provided. Results of GWAS provided for metaanalysis. |
Collaborator Contribution | academic partnership |
Impact | Lookup of GWAS association for 118 SNPs with 20 fingerprint features provided, full GWAS provided for metaanalysis, paper in preparation |
Start Year | 2018 |
Description | Reprogen |
Organisation | ReproGen Consortium |
Country | Global |
Sector | Academic/University |
PI Contribution | Conducting GWAS of reproductive traits. |
Collaborator Contribution | GWAS analyses complete. Currently doing lookup of existing (known) hits, and various heritability analyses. In discussion about future joint analyses/papers |
Impact | Association results from 31177 individuals for 247 variants supplied, revised manuscript submitted to Nature |
Start Year | 2017 |
Description | Short-and long-term effects of outdoor pollution |
Organisation | Chinese University of Hong Kong |
Country | Hong Kong |
Sector | Academic/University |
PI Contribution | Development of a programme of collaborative research to examine both short- and long- term effects of outdoor air pollution (together with climate model and geocoding) on health outcomes. Individual socio-demographic factors, as well as climate-related factors and indoor air pollutants would also be examined as independent and interacting factors which contribute to health outcomes. |
Collaborator Contribution | Development of a programme of collaborative research to examine both short- and long- term effects of outdoor air pollution (together with climate model and geocoding) on health outcomes. Individual socio-demographic factors, as well as climate-related factors and indoor air pollutants would also be examined as independent and interacting factors which contribute to health outcomes. |
Impact | Development of project: Assessing health risks associated with exposure to household and ambient air pollution in rural and urban China |
Start Year | 2017 |
Description | Social Science Genetics Association Consortium |
Organisation | Social Science Genetics Association Consortium |
Country | Global |
Sector | Charity/Non Profit |
PI Contribution | GWAS of socioeconomic traits, USC, USA, for the SSGAC consortium |
Collaborator Contribution | GWAS results supplied for ~10 different traits. |
Impact | ~12 sets of summary stats supplied. Manuscript to be submitted soon |
Start Year | 2018 |
Description | Spirometer/BiLEVE |
Organisation | University of Leicester |
Department | Department of Health Sciences |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Analysis in CKB of associations between spirometry measures/COPD and genetic loci identified by the Leicester group. |
Collaborator Contribution | Ongoing long-term collaboration. |
Impact | Two papers published in Nature Genetics "Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets", "New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries" |
Start Year | 2015 |
Description | UCL - Lipid traits - KK |
Organisation | Imperial College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Signals of natural selection for lipid traits |
Collaborator Contribution | Signals of natural selection for lipid traits |
Impact | Summary stats provided, data access provided to KK as visiting researcher, paper published in Nature Communications 2019, PMID: 31551420 |
Start Year | 2019 |
Description | UCL - Lipid traits - KK |
Organisation | University College London |
Department | Division of Psychiatry |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Signals of natural selection for lipid traits |
Collaborator Contribution | Signals of natural selection for lipid traits |
Impact | Summary stats provided, data access provided to KK as visiting researcher, paper published in Nature Communications 2019, PMID: 31551420 |
Start Year | 2019 |
Description | UK BiLEVE |
Organisation | UK Biobank |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | GWAS Data for ~33k subjects supplied to assist various meta analyses being conducted by this group. |
Collaborator Contribution | Consortium is investigating SNP and GRS associations with COPD and COPD exacerbations. |
Impact | One peer-reviewed paper published, others under preparation |
Start Year | 2017 |
Description | UNC School of Medicine - Psychiatric Genomes Consortium |
Organisation | University of North Carolina at Chapel Hill |
Country | United States |
Sector | Academic/University |
PI Contribution | GWAS of various psychiatric and related traits, |
Collaborator Contribution | Analysis plan received for GWAS of Major Depression and for Depressive Symptoms. GWAS completed, summary statistics supplied. |
Impact | Summary stats supplied, manuscript submitted to Nature Genetics, data access provided for supplementary analyses to KK as visitiing researcher from UCL under the Psychiatric Genomes Consortium |
Start Year | 2018 |
Description | University of Bristol |
Organisation | University of Bristol |
Department | MRC Integrative Epidemiology Unit |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Three projects: 1) GWAS of alcohol-related flushing and flushing 2) Within families GWAS of multiple traits 3) Mendelian randomisation of education |
Collaborator Contribution | Visiting researcher from Bristol working within CKB. |
Impact | Access to data for all three projects provided to visiting researcher. Analysese ongoing, Within families GWAS analyses completed for priority traits, manuscript submitted to Nature Genetics |
Start Year | 2018 |
Description | University of Cambridge |
Organisation | University of Cambridge |
Department | MRC Epidemiology Unit |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Provision of relevant baseline and follow-up data from CKB and guidance on anlaysis plans and interpretation of results. |
Collaborator Contribution | Cambridge will conduct an analysis of the associations between fish and soya bean intake and incidence of type 2 diabetes: an individual participant meta-analysis. |
Impact | papers under preparation |
Start Year | 2017 |
Description | University of Cambridge - Dept of Medicine |
Organisation | University of Cambridge |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Provision of controls data (300 CKB samples) for GWAS of ANCA vasculitis being conducted by Cambridge. |
Collaborator Contribution | The genotype data suppliedto Oxford is being used to compare the performance of the China Kadoorie Biobank and UK BioBank arrays in ethnically distinct cohorts. |
Impact | Joint research papers. |
Start Year | 2016 |
Description | University of Edinburgh |
Organisation | University of Edinburgh |
Department | Centre for Population Health Sciences |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Provision of relevant baseline and follow-up data from CKB and guidance on analysis plans and interpretation of results. |
Collaborator Contribution | Edinburgh will investigate and describe the association between socioeconomic status and prevalent and incident diabetes in China with investigation of the role of mediating and confounding factors. |
Impact | Papers under preparation |
Start Year | 2017 |
Description | University of Leicester |
Organisation | University of Leicester |
Department | Department of Health Sciences |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Access to data resulting from genotyping, joint analyses |
Collaborator Contribution | CKB has included additional custom respiratory content into its array design and Prof Tobin will assist in examining this GWAs data alongside baseline and prospective datasets |
Impact | Nature genetics paper. Nat Genet 2017; 49(3):416-425. |
Start Year | 2015 |
Description | University of Oulu |
Organisation | University of Oulu |
Country | Finland |
Sector | Academic/University |
PI Contribution | Results sent for 13 SNPs, 3 GRSs, 228 traits, up to 17k samples |
Collaborator Contribution | Meta-analysis of SNPs and gene-specific GRSs with lipid/NMR data. Also providing expertise on MNR metabolomics platform and analysis of CKB samples (stroke case-control study and Pancreatic cancer case-control study). |
Impact | paper published in Circulation: Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment |
Start Year | 2017 |
Description | University of Oxford - OCDEM |
Organisation | University of Oxford |
Department | Oxford Centre for Diabetes Endocrinology and Metabolism (OCDEM) |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Access to relevant CKB data including genomics data and diabetes outcome data. Paper drafting and internal genomics expertise and supervision. |
Collaborator Contribution | Provision of a post graduate research assistant working on the the identification and characterization of genetic variants that influence predisposition to type 2 diabetes and related traits. |
Impact | Contributed several novel and interesting findings including published research papers |
Start Year | 2014 |
Description | University of Oxford Biomedical Engineering |
Organisation | University of Oxford |
Department | Mathematical, Physical & Life Sciences Division |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Access to ECG wave data from CKB resurvey. Joint analyses. |
Collaborator Contribution | the development of machine learning methods for modelling ECG time series data within the CKB, and where we plan to develop tools for automatically fusing ECG-based data into disease sub-phenotyping for the CKB cohort. Also keen to explore other aspects of the CKB data resource, including genotypical biomarker data. |
Impact | One research paper published |
Start Year | 2014 |
Description | Urine NMR Metabolomics |
Organisation | University of Kuopio |
Country | Finland |
Sector | Academic/University |
PI Contribution | Provision of 25,000 CKB Urine samples and associated participant data for quantification of metabolites, |
Collaborator Contribution | Kuopio will employ a NMR-spectroscopy protocol that has been developed, optimized and validated by them to measure up to 50 biomarkers in all ~25,000 samples. Kuopio will quantify metabolite peaks and generate metabolite concentrations. Data will be available in absolute concentrations (?mol/L), as well as referenced to creatinine concentration. Data resultsin all ~25,000 samples will be shared with Oxford. As additional information for other metabolites becomes available using the NMR spectra, these will be provided to Oxford. |
Impact | Samples shipped, analyses being conducted |
Start Year | 2020 |
Description | Wellcome Trust Centre for Human Genetics |
Organisation | University of Oxford |
Department | Wellcome Trust Centre for Human Genetics |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | Access to data resulting from genotyping. |
Collaborator Contribution | Collaborated in the design of a customised genotyping array for genome-wide analysis, which is complementary to the UK Biobank array, and will facilitate future joint projects in the genomics of common diseases. |
Impact | Groups at the WTCHG work closely with the CKB team in genome wide data imputation and analysis, for work on stroke, as well as the partial cohort-wide genotyping funded by the MRC-Newton fund. |
Start Year | 2015 |
Description | Alcohol and CVD paper engangement activities |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Media coverage of publication of alcohol and CVD, including BBC TV and radio interviews, and a press conference for national newspapers, April 2019. |
Year(s) Of Engagement Activity | 2019 |
Description | Clinical Specialist workshop, China |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | PInvited presentation at the 6th annual joint conference of Chinese Stroke Association & Tiantan International Stroke Conference 2020 (CSA&TISC 2020) - Silent Stroke in Chinese Adults: Progress and Prognosis |
Year(s) Of Engagement Activity | 2020 |
Description | Festival of Genomics and Biodata |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Talk on "Using human genetics to improve the odds of drug development"" |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.festivalofgenomics.com/ |
Description | PE talk for CRUK |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | Over 100 students educated in the principles of a prospective epidemiological study |
Year(s) Of Engagement Activity | 2018,2019 |
Description | PE talk for CRUK |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | one public engagement talk at a fundraiser in aid of CRUK. It was on the 28th Oct 2017 |
Year(s) Of Engagement Activity | 2017 |
Description | Press coverage for research paper on egg consumption and cardiovascular disease in China |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Significant worldwide media coverage (Print and online) for the following paper "Associations of egg consumption with cardiovascular disease in a cohort study of 0.5 million Chinese adults". Heart 2018; 104(21):1756-63 |
Year(s) Of Engagement Activity | 2018 |
Description | Press coverage for research paper on high cholesterol and risk of stroke inc Radio interview for BBC radio Oxford. |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Global Press release and significant worldwide media coverage (Print and online) for the following paper: "Causal associations of blood lipids with risk of ischemic stroke and intracerebral hemorrhage in Chinese adults". Nature Medicine 2019. |
Year(s) Of Engagement Activity | 2019 |
Description | Press covereage for research paper loss-of-function variant in CETP and risk of CVD in Chinses adults |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Global Press release and significant worldwide media coverage (Print and online) for the following paper "Association of CETP gene variants with risk for vascular and nonvascular diseases among Chinese adults. JAMA Cardiol 2018; 3(1):34-43" |
Year(s) Of Engagement Activity | 2018 |
Description | Press covereage for research paper on solid fuel use and cardiovascular disease in China |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Global Press release and significant worldwide media coverage (Print and online) for the following paper: "Solid Fuel Use and Risks of Respiratory Diseases: A Cohort Study of 280,000 Chinese Never-Smokers". Am J Respir Crit Care Med 2019; 199(3):352-361 |
Year(s) Of Engagement Activity | 2018 |
Description | Talk at Laurus Ryecroft School |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | "A career as a physician scientist, pharmaceutical physician and epidemiologist" |
Year(s) Of Engagement Activity | 2020 |