Randomized trials in cardiovascular and metabolic diseases
Lead Research Organisation:
University of Oxford
Abstract
The aim of this programme is to demonstrate reliably any benefits of treatments that can be widely used in common diseases such as heart disease, diabetes, stroke and cancer. Even quite modest improvements in outcome in common conditions can lead to important benefits for patients. In order to be sure that treatments really work, large numbers of people usually need to be given the treatment and compared with similar people not given the treatment. The most reliable way to do this is using randomisation, a method whereby who gets given a treatment is determined by chance (like tossing a coin). These randomised trials also often involve masking (or blinding) the treatment so that neither the participants nor their doctors or nurses know if they are taking an active or dummy treatment, this helps with making the study reliable. Over the past several years, we have pioneered ways of running randomised trials involving thousands of people efficiently and cost-effectively to gain reliable information. We have developed a wide experience of using IT and centrally held health records to streamline the running of large trials. Partly why statin treatments are so widely used is as a result of studies that we have run. Ongoing studies include testing aspirin in people with diabetes and a new lipid changing drug added to statin therapy in people at high risk of heart problems.
Technical Summary
The aim of this programme is to generate reliable evidence about interventions with the potential for significant public health benefit. Treatments with even modest effects in common diseases (such as cancer, cardiovascular disease, diabetes, chronic kidney disease or osteoporosis) may make significant contributions to reducing morbidity and mortality globally. Building on epidemiological evidence generated in PHRU and elsewhere for associations between various biomarkers or risk factors (e.g. lipid markers, 25(OH) vitamin D), we aim to deliver large-scale randomised evidence to determine whether such associations are causal and reversible. Along with smoking and blood pressure, blood lipids are a major cause of cardiovascular disease, a major cause of morbidity and mortality worldwide. Higher levels of LDL cholesterol and lower levels of HDL cholesterol are associated with higher risks of coronary heart disease. Partly as a result of a series of large randomised trials (HPS, SEARCH and SHARP run by PHRU) and meta-analyses (also conducted by PHRU), statins, which effectively lower LDL cholesterol, are now very widely used for the primary and secondary prevention of cardiovascular disease. However, although widely used, available and highly cost-effective some patients remain at high risk despite statin use, thus additional safe treatments to modify risk are needed. Attention is now turning to newer drugs which modulate lipids by other mechanisms. The effects of such additional treatments on top of statins are likely to be modest, so large-scale randomised evidence are required to assess their effects reliably, hence the REVEAL trial of a cholesterol ester transfer protein inhibitor (CETPI) anacetrapib has randomized 30,000 people worldwide at risk of cardiovascular disease.
Over the last several years, PHRU has developed streamlined methods to recruit large numbers of patients and conduct trials efficiently (e.g. REVEAL) as well as cost-effectively (e.g. ASCEND), including using factorial designs to address more than one question at a time and using record linkage to facilitate follow-up, both during the trials (e.g. ASCEND, 3C, LENS) and in the longer-term (e.g. HPS, SEARCH). In addition, PHRU has piloted trials of non-commercial questions (e.g. high-dose vitamin D in older people) and of a combination of angiotensin receptor blocker and neprolysin inhibitor (ARNI) in chronic kidney disease with a view to securing funding for larger trials aiming to generate reliable evidence.
Dementia and other neurodegenerative diseases are also major causes of public health problems, and incur huge costs for families and health and social services, but they have been relatively poorly researched. Collaborating with other researchers, MADE and Schizophrenia ATLAS in neurodegenerative diseases will help answer important clinical questions and help build collaborations for the future.
Over the last several years, PHRU has developed streamlined methods to recruit large numbers of patients and conduct trials efficiently (e.g. REVEAL) as well as cost-effectively (e.g. ASCEND), including using factorial designs to address more than one question at a time and using record linkage to facilitate follow-up, both during the trials (e.g. ASCEND, 3C, LENS) and in the longer-term (e.g. HPS, SEARCH). In addition, PHRU has piloted trials of non-commercial questions (e.g. high-dose vitamin D in older people) and of a combination of angiotensin receptor blocker and neprolysin inhibitor (ARNI) in chronic kidney disease with a view to securing funding for larger trials aiming to generate reliable evidence.
Dementia and other neurodegenerative diseases are also major causes of public health problems, and incur huge costs for families and health and social services, but they have been relatively poorly researched. Collaborating with other researchers, MADE and Schizophrenia ATLAS in neurodegenerative diseases will help answer important clinical questions and help build collaborations for the future.
Organisations
- University of Oxford, United Kingdom (Collaboration, Lead Research Organisation)
- East Sussex Healthcare NHS Trust (Collaboration)
- Public Health England, Salisbury (Collaboration)
- King's Mill Hospital (Collaboration)
- Nottingham University Hospital NHS Trust, Nottingham (Collaboration)
- Birmingham Heartlands Hospital (Collaboration)
- John Radcliffe Hospital, United Kingdom (Collaboration)
- Norfolk and Norwich University Hospitals NHS Foundation Trust (Collaboration)
- Farnham Hospital (Collaboration)
- Hertford County Hospital (Collaboration)
- University of South Dakota (Collaboration)
- Doncaster and Bassetlaw Hospitals NHS Foundation Trust (Collaboration)
- The Medicines Company (Collaboration)
- Homerton University Hospital (Collaboration)
- Eagle Bridge Health and Wellbeing Centre (Collaboration)
- Hull Royal Infirmary, United Kingdom (Collaboration)
- Public Health Wales NHS Trust, United Kingdom (Collaboration)
- Mid Yorkshire Hospitals NHS Trust (Collaboration)
Publications

3C Study Collaborative Group
(2018)
Campath, calcineurin inhibitor reduction, and chronic allograft nephropathy (the 3C Study) - results of a randomized controlled clinical trial.
in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

3C Study Collaborative Group
(2018)
Campath, calcineurin inhibitor reduction, and chronic allograft nephropathy (the 3C Study) - results of a randomized controlled clinical trial.
in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Al-Shahi Salman R
(2019)
Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial
in The Lancet

Al-Shahi Salman R
(2021)
Effects of oral anticoagulation for atrial fibrillation after spontaneous intracranial haemorrhage in the UK: a randomised, open-label, assessor-masked, pilot-phase, non-inferiority trial
in The Lancet Neurology


ASCEND Study Collaborative Group
(2018)
Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus.
in The New England journal of medicine

ASCEND Study Collaborative Group
(2018)
Effects of n-3 Fatty Acid Supplements in Diabetes Mellitus.
in The New England journal of medicine



Baigent C
(2017)
Challenges in conducting clinical trials in nephrology: conclusions from a Kidney Disease-Improving Global Outcomes (KDIGO) Controversies Conference.
in Kidney international
Guideline Title | ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease |
Description | ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease |
Geographic Reach | North America |
Policy Influence Type | Citation in clinical guidelines |
Guideline Title | 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases |
Description | ASCEND results |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Citation in clinical guidelines |
Impact | 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD .The Task Force for diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and the European Association for the Study of Diabetes (EASD) |
Guideline Title | The Journal of Clinical Endocrinology & Metabolism |
Description | Treatment of diabetes in older adults |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Citation in clinical guidelines |
Description | BHF CRE Infrastructure Award Research grant: A comparison of the risk of cardiovascular events and cancer in the ASCEND study population with a similar population of people with diabetes identified using electronic primary care records. |
Amount | £30,000 (GBP) |
Organisation | British Heart Foundation (BHF) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2019 |
End | 03/2019 |
Description | BHF grant for ASCEND |
Amount | £1,078,553 (GBP) |
Funding ID | SP/14/331114 |
Organisation | British Heart Foundation (BHF) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2015 |
End | 12/2018 |
Description | National Institute for Health Research (NIHR) Infrastructure Visiting Speaker Award. |
Amount | £244 (GBP) |
Organisation | National Institute for Health Research |
Sector | Public |
Country | United Kingdom |
Start | 01/2018 |
End | 01/2018 |
Description | ASCEND-Eye |
Organisation | Birmingham Heartlands Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Collaborator Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Impact | tbc |
Start Year | 2018 |
Description | ASCEND-Eye |
Organisation | Doncaster and Bassetlaw Hospitals NHS Foundation Trust |
Department | Doncaster Royal Infirmary |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Collaborator Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Impact | tbc |
Start Year | 2018 |
Description | ASCEND-Eye |
Organisation | Eagle Bridge Health and Wellbeing Centre |
Country | United Kingdom |
Sector | Public |
PI Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Collaborator Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Impact | tbc |
Start Year | 2018 |
Description | ASCEND-Eye |
Organisation | East Sussex Healthcare NHS Trust |
Country | United Kingdom |
Sector | Public |
PI Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Collaborator Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Impact | tbc |
Start Year | 2018 |
Description | ASCEND-Eye |
Organisation | Farnham Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Collaborator Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Impact | tbc |
Start Year | 2018 |
Description | ASCEND-Eye |
Organisation | Hertford County Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Collaborator Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Impact | tbc |
Start Year | 2018 |
Description | ASCEND-Eye |
Organisation | Homerton University Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Collaborator Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Impact | tbc |
Start Year | 2018 |
Description | ASCEND-Eye |
Organisation | Hull Royal Infirmary |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Collaborator Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Impact | tbc |
Start Year | 2018 |
Description | ASCEND-Eye |
Organisation | John Radcliffe Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Collaborator Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Impact | tbc |
Start Year | 2018 |
Description | ASCEND-Eye |
Organisation | King's Mill Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Collaborator Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Impact | tbc |
Start Year | 2018 |
Description | ASCEND-Eye |
Organisation | Mid Yorkshire Hospitals NHS Trust |
Country | United Kingdom |
Sector | Public |
PI Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Collaborator Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Impact | tbc |
Start Year | 2018 |
Description | ASCEND-Eye |
Organisation | Norfolk and Norwich University Hospitals NHS Foundation Trust |
Country | United Kingdom |
Sector | Public |
PI Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Collaborator Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Impact | tbc |
Start Year | 2018 |
Description | ASCEND-Eye |
Organisation | Nottingham University Hospitals NHS Trust |
Department | Ropewalk House |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Collaborator Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Impact | tbc |
Start Year | 2018 |
Description | ASCEND-Eye |
Organisation | Public Health England |
Department | South West London Diabetic Eye Screening Programme |
Country | United Kingdom |
Sector | Public |
PI Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Collaborator Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Impact | tbc |
Start Year | 2018 |
Description | ASCEND-Eye |
Organisation | Public Health Wales NHS Trust |
Country | United Kingdom |
Sector | Public |
PI Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Collaborator Contribution | Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin. |
Impact | tbc |
Start Year | 2018 |
Description | BEST-D collaboration Nuffield Department of Clinical and Laboratory Sciences |
Organisation | University of Oxford |
Department | Nuffield Division of Clinical Laboratory Sciences |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | BEST-D study leads |
Collaborator Contribution | Shared blood samples for the BEST-D study. Undertaken study of impact of vitamin D on TRegulatory cells. |
Impact | Results are being written up |
Start Year | 2017 |
Description | ORION-4 |
Organisation | The Medicines Company |
Country | Global |
Sector | Private |
PI Contribution | New trial HPS-4/TIMI 65/ORION-4, collaboration with The Medicines Company on a large scale outcomes study of inclisiran. Funding agreed December 2017 from the Medicines Company to the University of Oxford. Further collaboration with TIMI study group and Harvard University to coordinate the trial. |
Collaborator Contribution | Funding for the study |
Impact | n/a |
Start Year | 2017 |
Description | University of South Dakota |
Organisation | University of South Dakota |
Country | United States |
Sector | Academic/University |
PI Contribution | knowledge sharing |
Collaborator Contribution | knowledge sharing |
Impact | n/a |
Start Year | 2018 |
Description | Adolescent Type 1 Diabetes Cardio-Renal Intervention Trialn (AdDIT) steering committee member |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Renal and Cardiovascular Risk According to Tertiles of Urinary Albumin-to-Creatinine Ratio: The Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT). Marcovecchio ML, Chiesa ST, Armitage J, Daneman D, Donaghue KC, Jones TW, Mahmud FH, Marshall SM, Neil HAW, Dalton RN, Deanfield J, Dunger DB; Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group. Diabetes Care 2018; 41(9) 1963-1969 |
Year(s) Of Engagement Activity | 2018 |
Description | CTAP Clinical Trial Advisory Panel member for Alzheimer's Research UK ESC Research Committee |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | CTAP Clinical Trial Advisory Panel member for Alzheimer's Research UK ESC Research Committee |
Year(s) Of Engagement Activity | 2018 |
Description | Can PPI improve recruitment and retention in clinical trials? |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | 'Can PPI improve recruitment and retention in clinical trials?' NIHR Evaluation, Trials and Studies Coordinating Centre, Southampton (2018). |
Year(s) Of Engagement Activity | 2018 |
Description | Cheltenham Science Festival |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | I spoke at the Cheltenham Science Festival on 6th June 2019 in a debate/discussion on cholesterol. |
Year(s) Of Engagement Activity | 2019 |
Description | Co-chair of Global risk-based monitoring |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | Sept 2018, Carol Knott invited as speaker and co-chair of 2 day conference: Global Risk-based Monitoring. Run in London for 60 attendees: Pharmaceutical Industry Quality Assurance Directors from across Europe. Outcome was sharing of methods of providing trial oversight without huge expenditure on routine on-site visits. |
Year(s) Of Engagement Activity | 2018 |
Description | INTERVAL steering committee |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | haired the steering Committee for the INTERVAL trial: Di Angelantonio E, Thompson SG, Kaptoge S, Moore C, Walker M, Armitage J, Ouwehand WH, Roberts DJ, Danesh J; INTERVAL Trial Group. Efficiency and safety of varying the frequency of whole blood donation (INTERVAL): a randomised trial of 45 000 donors. Lancet 2017;390:2360-2371 |
Year(s) Of Engagement Activity | 2018 |
Description | Media interviews at ESC 2018 |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Series of media interviews undertaken by Martin Landray and Louise Bowman as a result of the publication of results of the ASCEND Trial. The results were announced at ESC Congress, August 2017 in Barcelona. Interviews with a wide variety of media organisations from around the globe. |
Year(s) Of Engagement Activity | 2018 |
Description | Media interviews at ESC congress 2017 |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Series of media interviews undertaken by Martin Landray and Louise Bowman as a result of the publication of results of the REVEAL Trial. The results were announced at ESC Congress, August 2017 in Barcelona. Interviews with a wide variety of media organisations from around the globe. |
Year(s) Of Engagement Activity | 2017 |
Description | PIRRIST: A patient and public involvement (PPI) intervention to enhance recruitment and retention in surgical trials |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | 'PIRRIST: A patient and public involvement (PPI) intervention to enhance recruitment and retention in surgical trials.' Department of Health Sciences, University of York (2019). |
Year(s) Of Engagement Activity | 2019 |
Description | PIRRIST: A patient and public involvement (PPI) intervention to enhance recruitment and retention in surgical trials |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Crocker JC, Rees S, Locock L, Petit-Zeman S, Chant A, Treweek S, Cook JA, Farrar N, Woolfall K, Bostock J, Harmston R, Ferrey A, Bulbulia R. PIRRIST: A patient and public involvement (PPI) intervention to enhance recruitment and retention in surgical trials. Oral presentation at IDEAL Conference, Bristol, 2018. Published in International Journal of Surgery 2018; 59, Supplement 1: S-S2, #3. |
Year(s) Of Engagement Activity | 2018 |
Description | Radio 4 PM |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | I did an interview for Radio 4's PM on 16th April 2019 commenting on an observational study of statins and cholesterol levels. |
Year(s) Of Engagement Activity | 2019 |
Description | Workshop - Effective Monitoring in Clinical Trials |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | May 2018, Carol Knott Invited by University of Oslo to run a day long workshop: Effective Monitoring in Clinical Trials for 30 Monitors and Quality Assurance Managers from across Norway. The focus was on performing a trial risk assessment and implementing 'risk-based monitoring'. Follow-up advice also provided about identifying 'trigger factors' for making on-site visits. |
Year(s) Of Engagement Activity | 2018 |
Description | Workshop - Engaging tricky sites: hints and tips |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | May 2018, Carol Knott Invited to run an In-Conference workshop at Society for Clinical Trials (SCT 2018) Portland, Oregon, US: Engaging tricky sites: hints and tips. The focus was on managing research sites through the trial life-cycle, to maximize efficiency of recruitment and maintaining compliance. Worked with international panel self, plus 3 others to deliver workshop for 80 attendees. Follow-up advice has been sought and provided to 3 workshop attendees from US Universities developing monitoring plans |
Year(s) Of Engagement Activity | 2018 |