Stem cell bank

Lead Research Organisation: Nat Inst for Bio Standards and Control

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

10 25 50
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Andrews PW (2010) Human ES cell lines--introduction. in In vitro cellular & developmental biology. Animal

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Borstlap J (2008) Development of a European human embryonic stem cell registry. in Regenerative medicine

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Borstlap J (2008) First evaluation of the European hESCreg. in Nature biotechnology

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Cobo F (2006) Environmental monitoring in stem cell banks. in Applied microbiology and biotechnology

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Crook JM (2010) The International Stem Cell Banking Initiative (ISCBI): raising standards to bank on. in In vitro cellular & developmental biology. Animal

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Day JG (2008) Biobanking. in Molecular biotechnology

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Healy L (2011) Stem cell banks: preserving cell lines, maintaining genetic integrity, and advancing research. in Methods in molecular biology (Clifton, N.J.)

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International Stem Cell Banking Initiative (2009) Consensus guidance for banking and supply of human embryonic stem cell lines for research purposes. in Stem cell reviews

 
Description Best practice guidance on banking hESC lines for research
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact Principles of best practice publication in Stem Cell Rev Report 2009. Adopted by numerous oprganisations including japanese authorities and Calif Iinst for Regen Med
 
Description National Clinical hESC Forum
Geographic Reach Europe 
Policy Influence Type Membership of a guidance committee
Impact Providing best practice guidance for procurment of tissues, processing and testing for development of clinical grade hESC lines Interaction with HTA HFEA and MHRA has supported a UK proposal for a change in the EU Tissues and Cells Directive in 2012
 
Description Report to EMA Cell Therapy committee
Geographic Reach Europe 
Policy Influence Type Membership of a guidance committee
Impact Proivision of advice on testing and characterisation of cell therapy products
 
Description UK Stem Cell Therapy Road Map
Geographic Reach Asia 
Policy Influence Type Membership of a guidance committee
Impact Clarified regualtory pathways for different stem cell therapeutic products for commercial and healthcare organisations Highlighted some differences in definitions used by different regulators
 
Description WHO high level stem cell group
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in advisory committee
Impact Contruibuted to conclusions of WHO group on stem cells
 
Description hESCreg EC database as an EC tool to register ethically sourced hESC and hiPSC lines
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact Provided listing of international lines proposed for use in EC funded programmes This site is used by ECommssion to highlight hESC lines considered acceptable for use in EC funded research From 2014 registration on website is likely to be a prerequisite for use of lines in EC funded projects Project has been funded again from January 2016 for 5years
URL http://www.hescreg.eu/
 
Description hESSCO
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guidance committee
Impact Set best practice guidance for consent for stem cell research
 
Description Alternative testing cluster SEURAT-1 (Scr&Tox)
Amount £480,718 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2011 
End 12/2015
 
Description Alternative testing cluster SEURAT-1 (Toxbank)
Amount £251,697 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2011 
End 12/2016
 
Description EC FP6 EU hESC registry
Amount £150,000 (GBP)
Organisation Sixth Framework Programme (FP6) 
Sector Public
Country European Union (EU)
Start 03/2007 
End 02/2010
 
Description EC FP7 ESNATS
Amount £126,000 (GBP)
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 03/2008 
End 09/2013
 
Description International Stem Cell Forum
Amount £398,223 (GBP)
Organisation International Stem Cell Forum (ISCF) 
Sector Academic/University
Country Global
Start 03/2007 
End 07/2015
 
Description Tools
Amount £24,582 (GBP)
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 04/2010 
End 03/2011
 
Title Antibodies 
Description Standard antibodies ditributed to 17 international labs as part of ISCI project 
Type Of Material Technology assay or reagent 
Year Produced 2007 
Provided To Others? Yes  
Impact Publication Nat Biotech (2007) and archive of antibodies established at UKSCB 
URL http://www.stem-cell-forum.net/medical-research-council-uk/
 
Title Bank of 3T3 feeder cells for celltherapy 
Description Well documented source of 3T3 cells provided for use by skin engraftment andf limbal stem cell transplant groups in UK 
Type Of Material Cell line 
Year Produced 2006 
Provided To Others? Yes  
Impact Central source of qualified cells provided for UK health services at request of Department of Health Now under negotiation of agreements to permit International supply 
URL http://www.nibsc.org/uk_stem_cell_bank/cell_lines/mefs.aspx
 
Title MRC-5 feeder cells for cell therapy 
Description MRC-5 bank established in UKSCB cleanroom facilities 
Type Of Material Cell line 
Year Produced 2007 
Provided To Others? Yes  
Impact Cells with safe history of use inn vaccine manufacture made available to multiple groups for cell therapy development. 
 
Title human stem cell banks 
Description Banks of ethically sourced and quality controlled humna stem cell lines made available for public research and commercial development 
Type Of Material Cell line 
Year Produced 2006 
Provided To Others? Yes  
Impact Supporting research projects on stem cells for toxicology and and research in c80 other reserch organisations 
URL http://www.ukstemcellbank.org.uk
 
Description ESNATS 
Organisation TAP Biosystems
Country United Kingdom 
Sector Private 
PI Contribution Comparison and validation of different stem cell differentiation protocols to obtain different neuronal cell types
Collaborator Contribution Development of scale up and preservation protocols Development of differentiation protocols
Impact Publication : P DeSousa, S Mcrae and G Stacey Pluripotent stem cells as cellular product for regenerative medicine. In : Regenerative Medicine , In: Pluripotent Stem Cells and the Liver. Ed. D Hay , Science Publishers (2012 in press).
Start Year 2008
 
Description ESNATS 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Comparison and validation of different stem cell differentiation protocols to obtain different neuronal cell types
Collaborator Contribution Development of scale up and preservation protocols Development of differentiation protocols
Impact Publication : P DeSousa, S Mcrae and G Stacey Pluripotent stem cells as cellular product for regenerative medicine. In : Regenerative Medicine , In: Pluripotent Stem Cells and the Liver. Ed. D Hay , Science Publishers (2012 in press).
Start Year 2008
 
Description ESNATS 
Organisation University of Lausanne
Country Switzerland 
Sector Academic/University 
PI Contribution Comparison and validation of different stem cell differentiation protocols to obtain different neuronal cell types
Collaborator Contribution Development of scale up and preservation protocols Development of differentiation protocols
Impact Publication : P DeSousa, S Mcrae and G Stacey Pluripotent stem cells as cellular product for regenerative medicine. In : Regenerative Medicine , In: Pluripotent Stem Cells and the Liver. Ed. D Hay , Science Publishers (2012 in press).
Start Year 2008
 
Description International Stem Cell Banking Initiative 
Organisation International Stem Cell Forum (ISCF)
Department International Stem Cell Initiative
Country Global 
Sector Academic/University 
PI Contribution Led coordination of scientists and regulators from more than 20 countries and compiled reports and draft publications
Collaborator Contribution Consensus on best opractice (Andrews et al., Stem Cell Reports and Revs , Dec 2009). Stem cell bank self evaluation procedures (Stacey et al., Cell Stem Cell 2013). managing research data from stem cell lines (Isasi et al., Regen Med, 2012).
Impact Consensus on best practice in the procurement banking testing and release of hESC lines (2009) Andrews et al., (2015) Points to consider in the development of seed stocks of pluripotent stem cells for clinical applications. Regenerative Medicine. 10 (02s) doi: 10.2217/RME.14.93 Stacey GN. (in press) Stem Cell Banking: A Global Overview. In: Stem Cell Banking: Methods and Protocols, Human Press, Springer Science +Business Media LLC, USA.
Start Year 2007
 
Description International Stem Cell Banking Initiative 
Organisation International Stem Cell Forum (ISCF)
Country Global 
Sector Academic/University 
PI Contribution Led coordination of scientists and regulators from more than 20 countries and compiled reports and draft publications
Collaborator Contribution Consensus on best opractice (Andrews et al., Stem Cell Reports and Revs , Dec 2009). Stem cell bank self evaluation procedures (Stacey et al., Cell Stem Cell 2013). managing research data from stem cell lines (Isasi et al., Regen Med, 2012).
Impact Consensus on best practice in the procurement banking testing and release of hESC lines (2009) Andrews et al., (2015) Points to consider in the development of seed stocks of pluripotent stem cells for clinical applications. Regenerative Medicine. 10 (02s) doi: 10.2217/RME.14.93 Stacey GN. (in press) Stem Cell Banking: A Global Overview. In: Stem Cell Banking: Methods and Protocols, Human Press, Springer Science +Business Media LLC, USA.
Start Year 2007
 
Description International Stem Cell Initiative 
Organisation International Stem Cell Forum (ISCF)
Country Global 
Sector Academic/University 
PI Contribution Carried out characterisation testing, supplied stockc of antibodies, crried out independednt qualification of poor performing media
Collaborator Contribution three publications in In Vitro (2010) and Nature Biotech 2007 and in press
Impact Three publications in In Vitro (2010) and Nat Biotech (2007 and 2012) Stacey GN. (in press) Stem Cell Banking: A Global Overview. In: Stem Cell Banking: Methods and Protocols, Human Press, Springer Science +Business Media LLC, USA.
Start Year 2006
 
Title ABI Pluripotency gene expression chip 
Description Version of product developed in International Stem Cell Intitiative made available by ABI to research community 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Wide-scale adoption
Year Development Stage Completed 2007
Development Status Under active development/distribution
Impact Multiauthor publication in Nature Biotechnology ion 2007 described common characteristics of hESC lines in 17 expert hESC research labs. Reguklar citations. 
 
Title ABI virus detection card 
Description A microfluidics detection system fro multiple pathogenic viruses now available on market from ABI 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Initial development
Year Development Stage Completed 2010
Development Status Under active development/distribution
Impact A detection system available for screening research grade cell ines for viral contamiantion 
 
Title Cell culture surface treatments for GMP cell culture 
Description A culture surface treatment to mainrtain stem cell in pluripotent state 
Type Support Tool - For Medical Intervention
Current Stage Of Development Initial development
Year Development Stage Completed 2010
Development Status Actively seeking support
Impact Data for Orla company to promote further product development 
 
Description Cafe Scientific BishopsStrotford 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Presentation by UKSCB Director on stem cells and UKSCB role
Active engagement in dosucssion ran on after formal end of session

Requested further talks by NIBSC scientists
Year(s) Of Engagement Activity 2008
 
Description Hope not hype: open evening 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Local residents around NIBSC invited to a series of presentations by UKSCB staff stem cell scientists and ethicists

Positive feedback from residents on role of UKSCB
Year(s) Of Engagement Activity 2008
 
Description Presentations at scientific meetings 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Presentations more numerous than can be listed here. c30-50 presetnations per year at various scientific meetings including International Society for Stem Cell Reseaerch, UK Nat Stem Cell Network, MRC and BBSRC grant holders meetings, commercial conferences. Summaries given in Annual Reports available of UKSCB website

Ongoing invitations to attend scientific meetings
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010
 
Description UKSCB Open Forum 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact c50-100 attendees at UK National Stem Cell Network sessions run by UKSCB latterly run as a technical forum to engage researchers in the hESC and iPSC field

New contacts re potential UKSCB users
Year(s) Of Engagement Activity 2009,2010,2013,2014