Stem cell bank
Lead Research Organisation:
Nat Inst for Bio Standards and Control
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
People |
ORCID iD |
Glyn Nigel Stacey (Principal Investigator) |
Publications

Andrews PW
(2010)
Human ES cell lines--introduction.
in In vitro cellular & developmental biology. Animal

Borstlap J
(2008)
Development of a European human embryonic stem cell registry.
in Regenerative medicine

Borstlap J
(2008)
First evaluation of the European hESCreg.
in Nature biotechnology

Cobo F
(2006)
Environmental monitoring in stem cell banks.
in Applied microbiology and biotechnology

Crook JM
(2010)
The International Stem Cell Banking Initiative (ISCBI): raising standards to bank on.
in In vitro cellular & developmental biology. Animal

Day JG
(2008)
Biobanking.
in Molecular biotechnology

Elstner A
(2009)
The changing landscape of European and international regulation on embryonic stem cell research.
in Stem cell research

Healy L
(2011)
Stem cell banks: preserving cell lines, maintaining genetic integrity, and advancing research.
in Methods in molecular biology (Clifton, N.J.)

Healy LE
(2008)
International banking: checks, deposits, and withdrawals.
in Cell stem cell

International Stem Cell Banking Initiative
(2009)
Consensus guidance for banking and supply of human embryonic stem cell lines for research purposes.
in Stem cell reviews and reports
Description | Best practice guidance on banking hESC lines for research |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Citation in other policy documents |
Impact | Principles of best practice publication in Stem Cell Rev Report 2009. Adopted by numerous oprganisations including japanese authorities and Calif Iinst for Regen Med |
Description | National Clinical hESC Forum |
Geographic Reach | Europe |
Policy Influence Type | Membership of a guidance committee |
Impact | Providing best practice guidance for procurment of tissues, processing and testing for development of clinical grade hESC lines Interaction with HTA HFEA and MHRA has supported a UK proposal for a change in the EU Tissues and Cells Directive in 2012 |
Description | Report to EMA Cell Therapy committee |
Geographic Reach | Europe |
Policy Influence Type | Membership of a guidance committee |
Impact | Proivision of advice on testing and characterisation of cell therapy products |
Description | UK Stem Cell Therapy Road Map |
Geographic Reach | Asia |
Policy Influence Type | Membership of a guidance committee |
Impact | Clarified regualtory pathways for different stem cell therapeutic products for commercial and healthcare organisations Highlighted some differences in definitions used by different regulators |
Description | WHO high level stem cell group |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Participation in advisory committee |
Impact | Contruibuted to conclusions of WHO group on stem cells |
Description | hESCreg EC database as an EC tool to register ethically sourced hESC and hiPSC lines |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Membership of a guideline committee |
Impact | Provided listing of international lines proposed for use in EC funded programmes This site is used by ECommssion to highlight hESC lines considered acceptable for use in EC funded research From 2014 registration on website is likely to be a prerequisite for use of lines in EC funded projects Project has been funded again from January 2016 for 5years |
URL | http://www.hescreg.eu/ |
Description | hESSCO |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Membership of a guidance committee |
Impact | Set best practice guidance for consent for stem cell research |
Description | Alternative testing cluster SEURAT-1 (Scr&Tox) |
Amount | £480,718 (GBP) |
Funding ID | 266753 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 01/2011 |
End | 12/2015 |
Description | Alternative testing cluster SEURAT-1 (Toxbank) |
Amount | £251,697 (GBP) |
Funding ID | 267042 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 01/2011 |
End | 12/2016 |
Description | EC FP6 EU hESC registry |
Amount | £150,000 (GBP) |
Funding ID | 37820 |
Organisation | Sixth Framework Programme (FP6) |
Sector | Public |
Country | European Union (EU) |
Start | 03/2007 |
End | 02/2010 |
Description | EC FP7 ESNATS |
Amount | £126,000 (GBP) |
Funding ID | 201619 |
Organisation | European Commission |
Department | Seventh Framework Programme (FP7) |
Sector | Public |
Country | European Union (EU) |
Start | 03/2008 |
End | 09/2013 |
Description | International Stem Cell Forum |
Amount | £398,223 (GBP) |
Organisation | International Stem Cell Forum (ISCF) |
Sector | Academic/University |
Country | Global |
Start | 03/2007 |
End | 07/2015 |
Description | Tools |
Amount | £24,582 (GBP) |
Organisation | Innovate UK |
Sector | Public |
Country | United Kingdom |
Start | 03/2010 |
End | 03/2011 |
Title | Antibodies |
Description | Standard antibodies ditributed to 17 international labs as part of ISCI project |
Type Of Material | Technology assay or reagent |
Year Produced | 2007 |
Provided To Others? | Yes |
Impact | Publication Nat Biotech (2007) and archive of antibodies established at UKSCB |
URL | http://www.stem-cell-forum.net/medical-research-council-uk/ |
Title | Bank of 3T3 feeder cells for celltherapy |
Description | Well documented source of 3T3 cells provided for use by skin engraftment andf limbal stem cell transplant groups in UK |
Type Of Material | Cell line |
Year Produced | 2006 |
Provided To Others? | Yes |
Impact | Central source of qualified cells provided for UK health services at request of Department of Health Now under negotiation of agreements to permit International supply |
URL | http://www.nibsc.org/uk_stem_cell_bank/cell_lines/mefs.aspx |
Title | MRC-5 feeder cells for cell therapy |
Description | MRC-5 bank established in UKSCB cleanroom facilities |
Type Of Material | Cell line |
Year Produced | 2007 |
Provided To Others? | Yes |
Impact | Cells with safe history of use inn vaccine manufacture made available to multiple groups for cell therapy development. |
Title | human stem cell banks |
Description | Banks of ethically sourced and quality controlled humna stem cell lines made available for public research and commercial development |
Type Of Material | Cell line |
Year Produced | 2006 |
Provided To Others? | Yes |
Impact | Supporting research projects on stem cells for toxicology and and research in c80 other reserch organisations |
URL | http://www.ukstemcellbank.org.uk |
Description | ESNATS |
Organisation | TAP Biosystems |
Country | United Kingdom |
Sector | Private |
PI Contribution | Comparison and validation of different stem cell differentiation protocols to obtain different neuronal cell types |
Collaborator Contribution | Development of scale up and preservation protocols Development of differentiation protocols |
Impact | Publication : P DeSousa, S Mcrae and G Stacey Pluripotent stem cells as cellular product for regenerative medicine. In : Regenerative Medicine , In: Pluripotent Stem Cells and the Liver. Ed. D Hay , Science Publishers (2012 in press). |
Start Year | 2008 |
Description | ESNATS |
Organisation | University of Edinburgh |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Comparison and validation of different stem cell differentiation protocols to obtain different neuronal cell types |
Collaborator Contribution | Development of scale up and preservation protocols Development of differentiation protocols |
Impact | Publication : P DeSousa, S Mcrae and G Stacey Pluripotent stem cells as cellular product for regenerative medicine. In : Regenerative Medicine , In: Pluripotent Stem Cells and the Liver. Ed. D Hay , Science Publishers (2012 in press). |
Start Year | 2008 |
Description | ESNATS |
Organisation | University of Lausanne |
Country | Switzerland |
Sector | Academic/University |
PI Contribution | Comparison and validation of different stem cell differentiation protocols to obtain different neuronal cell types |
Collaborator Contribution | Development of scale up and preservation protocols Development of differentiation protocols |
Impact | Publication : P DeSousa, S Mcrae and G Stacey Pluripotent stem cells as cellular product for regenerative medicine. In : Regenerative Medicine , In: Pluripotent Stem Cells and the Liver. Ed. D Hay , Science Publishers (2012 in press). |
Start Year | 2008 |
Description | International Stem Cell Banking Initiative |
Organisation | International Stem Cell Forum (ISCF) |
Department | International Stem Cell Initiative |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Led coordination of scientists and regulators from more than 20 countries and compiled reports and draft publications |
Collaborator Contribution | Consensus on best opractice (Andrews et al., Stem Cell Reports and Revs , Dec 2009). Stem cell bank self evaluation procedures (Stacey et al., Cell Stem Cell 2013). managing research data from stem cell lines (Isasi et al., Regen Med, 2012). |
Impact | Consensus on best practice in the procurement banking testing and release of hESC lines (2009) Andrews et al., (2015) Points to consider in the development of seed stocks of pluripotent stem cells for clinical applications. Regenerative Medicine. 10 (02s) doi: 10.2217/RME.14.93 Stacey GN. (in press) Stem Cell Banking: A Global Overview. In: Stem Cell Banking: Methods and Protocols, Human Press, Springer Science +Business Media LLC, USA. |
Start Year | 2007 |
Description | International Stem Cell Banking Initiative |
Organisation | International Stem Cell Forum (ISCF) |
Country | Global |
Sector | Academic/University |
PI Contribution | Led coordination of scientists and regulators from more than 20 countries and compiled reports and draft publications |
Collaborator Contribution | Consensus on best opractice (Andrews et al., Stem Cell Reports and Revs , Dec 2009). Stem cell bank self evaluation procedures (Stacey et al., Cell Stem Cell 2013). managing research data from stem cell lines (Isasi et al., Regen Med, 2012). |
Impact | Consensus on best practice in the procurement banking testing and release of hESC lines (2009) Andrews et al., (2015) Points to consider in the development of seed stocks of pluripotent stem cells for clinical applications. Regenerative Medicine. 10 (02s) doi: 10.2217/RME.14.93 Stacey GN. (in press) Stem Cell Banking: A Global Overview. In: Stem Cell Banking: Methods and Protocols, Human Press, Springer Science +Business Media LLC, USA. |
Start Year | 2007 |
Description | International Stem Cell Initiative |
Organisation | International Stem Cell Forum (ISCF) |
Country | Global |
Sector | Academic/University |
PI Contribution | Carried out characterisation testing, supplied stockc of antibodies, crried out independednt qualification of poor performing media |
Collaborator Contribution | three publications in In Vitro (2010) and Nature Biotech 2007 and in press |
Impact | Three publications in In Vitro (2010) and Nat Biotech (2007 and 2012) Stacey GN. (in press) Stem Cell Banking: A Global Overview. In: Stem Cell Banking: Methods and Protocols, Human Press, Springer Science +Business Media LLC, USA. |
Start Year | 2006 |
Title | ABI Pluripotency gene expression chip |
Description | Version of product developed in International Stem Cell Intitiative made available by ABI to research community |
Type | Diagnostic Tool - Non-Imaging |
Current Stage Of Development | Wide-scale adoption |
Year Development Stage Completed | 2007 |
Development Status | Under active development/distribution |
Impact | Multiauthor publication in Nature Biotechnology ion 2007 described common characteristics of hESC lines in 17 expert hESC research labs. Reguklar citations. |
Title | ABI virus detection card |
Description | A microfluidics detection system fro multiple pathogenic viruses now available on market from ABI |
Type | Diagnostic Tool - Non-Imaging |
Current Stage Of Development | Initial development |
Year Development Stage Completed | 2010 |
Development Status | Under active development/distribution |
Impact | A detection system available for screening research grade cell ines for viral contamiantion |
Title | Cell culture surface treatments for GMP cell culture |
Description | A culture surface treatment to mainrtain stem cell in pluripotent state |
Type | Support Tool - For Medical Intervention |
Current Stage Of Development | Initial development |
Year Development Stage Completed | 2010 |
Development Status | Actively seeking support |
Impact | Data for Orla company to promote further product development |
Description | Cafe Scientific BishopsStrotford |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Type Of Presentation | Keynote/Invited Speaker |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Presentation by UKSCB Director on stem cells and UKSCB role Active engagement in dosucssion ran on after formal end of session Requested further talks by NIBSC scientists |
Year(s) Of Engagement Activity | 2008 |
Description | Hope not hype: open evening |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Type Of Presentation | Workshop Facilitator |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Local residents around NIBSC invited to a series of presentations by UKSCB staff stem cell scientists and ethicists Positive feedback from residents on role of UKSCB |
Year(s) Of Engagement Activity | 2008 |
Description | Presentations at scientific meetings |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Presentations more numerous than can be listed here. c30-50 presetnations per year at various scientific meetings including International Society for Stem Cell Reseaerch, UK Nat Stem Cell Network, MRC and BBSRC grant holders meetings, commercial conferences. Summaries given in Annual Reports available of UKSCB website Ongoing invitations to attend scientific meetings |
Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010,2011,2012,2013,2014 |
Description | UKSCB Open Forum |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | c50-100 attendees at UK National Stem Cell Network sessions run by UKSCB latterly run as a technical forum to engage researchers in the hESC and iPSC field New contacts re potential UKSCB users |
Year(s) Of Engagement Activity | 2009,2010,2013,2014 |