GRL - Prof Steel
Lead Research Organisation:
Wellcome Sanger Institute
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
Special contribution relates to the transfer of Professor Steels programme from MRC Institute of Hearing research to the Wellcome Trust Sanger institute. Abstract: Hearing impairment is very common in humans, but it is also a very heterogeneous disorder, with a wide range of causes. For example, there are probably several hundred genes involved in deafness, any one of which can be mutated and cause deafness in an individual. This makes it difficult to study directly in humans. The long-term aim of the work described here is to develop medical treatments for hearing impairment to provide an alternative to the imperfect approaches of amplification and cochlear implantation presently available. Developing new approaches must build upon improved understanding of the causes of hearing impairment and accurate diagnosis. A genetic approach, using hearing-impaired mouse mutants, is adopted to identify the key molecules in the development and function of hearing. As we assemble more of the molecular components, we not only will facilitate the development of generic approaches to treatment, but also establish which are most commonly involved in deafness in the human population. Further work can then focus upon the most common causes of human deafness. In this proposal, I outline plans to build upon the current work of my group to a) investigate the molecular basis of the development of sensory patches in the inner ear, b) investigate the role of key molecules in hair cell development and function, c) use mutants we have studied with a broad range of specific defects to develop diagnostic tools for particular pathologies, and d) screen newly-generated mouse mutants for evidence of hearing and/or balance defects, characterise their pathology, and ask which of the genes involved are associated with deafness in humans.
Organisations
- Wellcome Sanger Institute (Lead Research Organisation)
- University College London (Collaboration)
- University of Michigan (Collaboration)
- EMBL European Bioinformatics Institute (EMBL - EBI) (Collaboration)
- Chongqing University (Collaboration)
- University of Sheffield (Collaboration)
- Hospital Ramón y Cajal (Collaboration)
- Emory University (Collaboration)
- Medical University of South Carolina (Collaboration)
- University of Helsinki (Collaboration)
- Venetian Institute of Molecular Medicine (Collaboration)
- National Institutes of Health (NIH) (Collaboration)
- University Medical Center Gronigen (Collaboration)
People |
ORCID iD |
Publications
Ziff JL
(2016)
Mutations and altered expression of SERPINF1 in patients with familial otosclerosis.
in Human molecular genetics
Wolber LE
(2014)
Salt-inducible kinase 3, SIK3, is a new gene associated with hearing.
in Human molecular genetics
Warren M
(2007)
A Sall4 mutant mouse model useful for studying the role of Sall4 in early embryonic development and organogenesis.
in Genesis (New York, N.Y. : 2000)
Tuck E
(2015)
A gene expression resource generated by genome-wide lacZ profiling in the mouse.
in Disease models & mechanisms
Thoenes M
(2015)
OSBPL2 encodes a protein of inner and outer hair cell stereocilia and is mutated in autosomal dominant hearing loss (DFNA67).
in Orphanet journal of rare diseases
Spiden SL
(2008)
The novel mouse mutation Oblivion inactivates the PMCA2 pump and causes progressive hearing loss.
in PLoS genetics
Simon MM
(2013)
A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains.
in Genome biology
Schütz M
(2010)
The human deafness-associated connexin 30 T5M mutation causes mild hearing loss and reduces biochemical coupling among cochlear non-sensory cells in knock-in mice.
in Human molecular genetics
| Description | British Tinnitus Association roundtable at the House of Commons |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Election to Royal Society Council |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Description | Membership of Royal Society Science Policy Committee |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Description | Roundtable on Adult Hearing Loss and Tinnitus Research |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| Description | Royal Society Grants Committee |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Assisted transfer strategic award |
| Amount | £1,500,000 (GBP) |
| Funding ID | WT100669MA |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2012 |
| End | 09/2018 |
| Description | BBSRC project grants |
| Amount | £447,982 (GBP) |
| Funding ID | BB/M02069X/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2015 |
| End | 06/2018 |
| Description | Characterising new mouse knockouts of candidate genes from human hearing studies |
| Amount | £159,920 (GBP) |
| Funding ID | G73 |
| Organisation | Action on Hearing Loss |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2015 |
| End | 01/2018 |
| Description | Determining the limits for reversing hearing loss |
| Amount | £1,947,704 (GBP) |
| Funding ID | 221769/Z/20/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2021 |
| End | 02/2026 |
| Description | Diagnostic tools for stratifying age-related progressive hearing loss by pathological features |
| Amount | £160,000 (GBP) |
| Funding ID | G86 |
| Organisation | Action on Hearing Loss |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2017 |
| End | 01/2020 |
| Description | Discovery grant |
| Amount | £200,000 (GBP) |
| Funding ID | G100_STEEL |
| Organisation | Action on Hearing Loss |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2021 |
| End | 08/2025 |
| Description | EUMODIC |
| Amount | £2,000,000 (GBP) |
| Funding ID | 37188 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 01/2007 |
| End | 01/2012 |
| Description | Exploration of lipidomics as a diagnostic tool for different forms of hearing loss |
| Amount | £10,000 (GBP) |
| Funding ID | F97 |
| Organisation | Action on Hearing Loss |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2019 |
| End | 03/2020 |
| Description | ITN LISTEN |
| Amount | € 2,584,755 (EUR) |
| Funding ID | 722098 - LISTEN |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 12/2016 |
| End | 11/2020 |
| Description | MRC project grant |
| Amount | £640,097 (GBP) |
| Funding ID | MR/N012119/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2016 |
| End | 06/2019 |
| Description | PhD Studentship |
| Amount | £76,500 (GBP) |
| Funding ID | S28 Steel |
| Organisation | Action on Hearing Loss |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2013 |
| End | 09/2016 |
| Title | Development of advanced protocols for ABR analysis of auditory function |
| Description | We have developed a new battery of tests that we use to ask if mouse mutants show any defects in frequency selectivity or temporal processing. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Provided To Others? | No |
| Impact | Main research is in progress. |
| Title | New deaf mouse mutants |
| Description | The funding has contributed to the production of many new mouse mutants affecting genes thought to be involved in auditory development or function |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | These new mutants are in the early stages of study, but it looks as if many unexpected genes underlie deafness, while other genes previously thought to be good candidates do not in fact lead to deafness. Around 3% (9/313) of all genes screened so far are associated with hearing impairment, and additional genes are associated with supra-threshold anomalies that we are currently following up. |
| Title | Software and other support for ABR recordings |
| Description | We supply software that we developed for optimised recording and analysis of Auditory Brainstem Response measurements to assess hearing ability in mice. Also, we supply details of the equipment needed and we host visits by researchers wanting to set the system up in their own lab. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | The ABR screen using this method has been adopted by the International Mouse Phenotyping Consortium and new data from targeted mouse mutants will emerge to add to our own screening data currently from over 600 new mutant lines, all available on the Sanger Institute Mouse portal |
| Title | Deafness gene list |
| Description | Manually-curated catalogue of genes known to be involved in hearing impairment in humans and/or mouse |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | This list has been used to prioritise candidate genes for further analysis. |
| Description | Analysis of Synaptojanin2 mutant mouse |
| Organisation | University of Sheffield |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We generated the derived tm1b allele from the original tm1a mutation, carried out ABRs, DPOAEs, expression studies, scanning electron microscopy, confocal imaging of innervation of hair cells, and characterisation of the effects of the allele on expression levels. |
| Collaborator Contribution | Single hair cell recordings. |
| Impact | So far a chapter in the student's thesis which is being adapted to form the basis of a publication. This project has now been published: doi: 10.3389/fncel.2020.561857. |
| Start Year | 2014 |
| Description | Bioinformatic analysis of microarray data |
| Organisation | EMBL European Bioinformatics Institute (EMBL - EBI) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have generated the microarray data and carried out the remaining experiments required for each study, and contributed to the design, conduct, analysis and writing up of the work. |
| Collaborator Contribution | Our collaborators have analysed out microarray data and provided descriptions and analyses of the results and contributed to the interpretation and writing up of the data. |
| Impact | 19363478 |
| Start Year | 2008 |
| Description | Chinese deaf children |
| Organisation | Chongqing University |
| Country | China |
| Sector | Academic/University |
| PI Contribution | We have proposed candidate genes for involvement in deafness from our mouse studies, and our collaborators included these genes in their targeted pulldown design followed by sequencing of DNA samples from affected children. We have followed up by further analysis of the specific mutations discovered associated with deafness |
| Collaborator Contribution | See above. The Chinese collaborators recruited a very large sample of deaf children for DNA analysis, carried out the pulldown and sequencing, and followed up by looking at parents. |
| Impact | The first joint paper was published this year, Bunillo et al. in EMBO Molecular Medicine. |
| Start Year | 2011 |
| Description | Emx2 in pituitary gland |
| Organisation | University of Michigan |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Our contribution was to provide genotyped, embedded and sectioned material of Emx2 mutants and littermate controls for analysis by our collaborators. We contributed to the design of the relevant part of the work, the conduct, and the writing up of the work. |
| Collaborator Contribution | Our collaborators carried out the majority of the research described. |
| Impact | 19407506 |
| Start Year | 2007 |
| Description | Functional analysis of Mir96 mutant hair cells |
| Organisation | University of Sheffield |
| Department | Department of Biomedical Science |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have contributed to the collection of experimental data and to the design, conduct, analysis and writing up of the work. |
| Collaborator Contribution | Our collaborators have contributed to the collection of experimental data and the analysis, interpretation and writing up of the findings. |
| Impact | 21245307 |
| Start Year | 2008 |
| Description | Genotype/phenotype analysis in Usher syndrome |
| Organisation | University College London |
| Department | Institute of Ophthalmology UCL |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We provided the sequencing of the patient DNA and the initial sequence analysis and contributed to the design, conduct, analysis and writing up of the work. |
| Collaborator Contribution | Our collaborators carried out the detailed clinical assessments of the patients in this study and contributed to the design, conduct, analysis and writing up of the work. |
| Impact | 21487335 |
| Start Year | 2007 |
| Description | Hearing in the Cx30 T5M mutant |
| Organisation | Venetian Institute of Molecular Medicine |
| Country | Italy |
| Sector | Academic/University |
| PI Contribution | We established our own in house breeding colony of these mutants, used offspring of all genotypes to measure endocochlear potential in the cochlea, and contributed to writing the manuscript. |
| Collaborator Contribution | Our collaborators carried out experimental work on the mutant mice and contributed to the design, materials, conduct, analysis and writing up of the work. |
| Impact | 20858605 |
| Start Year | 2009 |
| Description | Human exome sequence analysis for age-related hearing loss |
| Organisation | Medical University of South Carolina |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | We are analysing the exome sequence, selecting candidate variants, knocking these into mice and investigating the effects on hearing. |
| Collaborator Contribution | The collaborators have assembled a large cohort of people with very well-characterised hearing function, mostly with hearing impairment, and collected samples for exome sequencing. |
| Impact | One publication, Lewis et al 2018. Yes, highly multi-disciplinary. |
| Start Year | 2017 |
| Description | Investigations of Mir96 role in hearing |
| Organisation | Hospital Ramón y Cajal |
| Country | Spain |
| Sector | Hospitals |
| PI Contribution | We are analysing two mouse lines with hiuman MIR96 mutations knocked in. |
| Collaborator Contribution | They have identified the human mutations and are now investigating the possibility of using nasal biopsy cultures for drug screening. |
| Impact | Lewis et al 2009 Mencia et al 2009 |
| Start Year | 2009 |
| Description | Mir96 in human and mouse deafness |
| Organisation | Hospital Ramón y Cajal |
| Country | Spain |
| Sector | Hospitals |
| PI Contribution | We have contributed all of the work on the mouse mutation in Mir96 including identification of the gene involved as a microRNA and characterisation of the phenotype of the mouse. |
| Collaborator Contribution | Our collaborators have contributed to our combined effort to identify the mutations responsible for progressive hearing loss in mice and humans, in particular carrying out all of the work on human families. |
| Impact | 19363479; 19363478 |
| Start Year | 2006 |
| Description | Modelling of a new Isl1 mutation |
| Organisation | EMBL European Bioinformatics Institute (EMBL - EBI) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We discovered the mutation, established the phenotype, and designed the experiments, carried out the experimental work, analysed the results and wrote the paper. |
| Collaborator Contribution | Our collaborator modelled the new mutation in Isl1 and its probable effect on protein interactions and drafted the text describing this for the publication |
| Impact | 21936904 |
| Start Year | 2011 |
| Description | Phenotypes of Tbx1 and Chd7 mouse mutants |
| Organisation | University College London |
| Department | Institute of Child Health |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We prepared the inner ears for paint-filling and analysed the malformations, and contributed to writing the relevant parts of the paper. |
| Collaborator Contribution | Dr Scambler and his colleagues carried out the mouse breeding experiments and detailed analysis of head development, and provided fixed inner ears for us to examine and analyse. |
| Impact | 19855134 |
| Start Year | 2008 |
| Description | Role of Wnt5a in ear development |
| Organisation | Emory University |
| Department | Emory School of Medicine |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | We have carried out a scanning electron microscopic analysis of the organ of Corti in Wnt5a mutant mouse samples from our collaborator and contributed to the design, conduct, analysis and writing up of the work. |
| Collaborator Contribution | Our collaborators have carried out a detailed analysis of the development of the organ of Corti in the Wnt5a mouse mutant and contributed to the design, conduct, analysis and writing up of the work. |
| Impact | 17433286 |
| Start Year | 2006 |
| Description | Role of twinfilin in hair cells |
| Organisation | University of Helsinki |
| Country | Finland |
| Sector | Academic/University |
| PI Contribution | We carried out experimental work on the role of twinfilin in the development of stereocilia bundles on hair cells. We contributed to the design, materials, conduct, analysis and writing up of the work. |
| Collaborator Contribution | Our collaborators provided essential materials for the analysis of the role of twinfilin in hair cell development and carried out some of the exeriments in Helsinki. They contributed to the design, conduct, analysis and writing up of the work. |
| Impact | 19774077 |
| Start Year | 2007 |
| Description | Smell and reproductive organs in Chd7 mice |
| Organisation | University Medical Center Gronigen |
| Country | Netherlands |
| Sector | Hospitals |
| PI Contribution | We carried out all the work jointly with the clinician student from Groningen in my laboratory. We contributed to the design, materials, conduct, analysis and writing up of the work. |
| Collaborator Contribution | Our collaborators sent a clinician student to my laboratory to carry out basic mouse research and contributed to the design, analysis and writing up of the work. |
| Impact | 19809474 |
| Start Year | 2007 |
| Description | Study of Ildr4 mutation |
| Organisation | National Institutes of Health (NIH) |
| Department | National Institute on Deafness and Other Communication Disorders (NIDCD) |
| Country | United States |
| Sector | Public |
| PI Contribution | Phalloidin labelling to examine hair bundles in the mutants and littermate controls. Endocochlear potential measurements and ABR analysis. Analysing and writing up relevant parts of the publication. |
| Collaborator Contribution | The partners carried out the rest of the analyses published. |
| Impact | A publication was the result. |
| Start Year | 2014 |
| Description | Study of Ildr4 mutation |
| Organisation | National Institutes of Health (NIH) |
| Department | National Institute on Deafness and Other Communication Disorders (NIDCD) |
| Country | United States |
| Sector | Public |
| PI Contribution | Phalloidin labelling to examine hair bundles in the mutants and littermate controls. Endocochlear potential measurements and ABR analysis. Analysing and writing up relevant parts of the publication. |
| Collaborator Contribution | The partners carried out the rest of the analyses published. |
| Impact | A publication was the result. |
| Start Year | 2014 |
| Title | Popcorn, a software for linking genes to upstream regulators in a network |
| Description | Popcorn, a software for linking genes to upstream regulators in a network. Used for analysis of networks, linking genes that are not otherwise discoverable using existing software. The details will be published soon, but it is available on GitHub now. Software written and developed by Dr Morag Lewis. |
| Type Of Technology | Software |
| Year Produced | 2020 |
| Open Source License? | Yes |
| Impact | We have used this software to draw up a network, soon to be published (Lewis et al). |
| Title | Popcorn, a software for linking genes to upstream regulators in a network |
| Description | Popcorn, a software for linking genes to upstream regulators in a network. Used for analysis of networks, linking genes that are not otherwise discoverable using existing software. The details will be published soon, but it is available on GitHub now. Software written and developed by Dr Morag Lewis. |
| Type Of Technology | Software |
| Year Produced | 2020 |
| Open Source License? | Yes |
| Impact | We have used this software to draw up a network, soon to be published (Lewis et al). |
| Title | Software for recording and analysing auditory responses |
| Description | Software for recording and analysing auditory responses |
| Type Of Technology | Software |
| Year Produced | 2008 |
| Impact | We have distributed this software free of charge to around ten other laboratories working on recording auditory responses from mutant mice, around the world. |
| Description | AoHL supporters laboratory visit |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Supporters |
| Results and Impact | We hosted a visit of around 30 active supporters of the charity Action on Hearing Loss plus 6 charity staff, who visited the labs, watched demonstrations of research methods, listened to talks and posters, and discussed our research. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Brain prize talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | I presented a talk at the Brain Prize ceremony, attended by many Danish lay people, politicians, health researchers, etc. Requests for further outreach talks in Denmark |
| Year(s) Of Engagement Activity | 2012 |
| Description | ECNP plenary talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Over 1000 clinical psychologists attended Not known yet |
| Year(s) Of Engagement Activity | 2013 |
| Description | Interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview and article with The Scientist magazine |
| Year(s) Of Engagement Activity | 2015 |
| Description | Interview for Naked Scientist |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Not known yet |
| Year(s) Of Engagement Activity | 2013 |
| Description | Interview for journal article |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | I was interviewed for an on-line video and/or journal frontpiece article for four articles. Nothing known |
| Year(s) Of Engagement Activity | 2010,2011,2012 |
| Description | Interview on BBC TV programme See Hear |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | An extended interview was broadcast, resulting in a number of positive comments about the content and manner of the interview. None known |
| Year(s) Of Engagement Activity | 2010 |
| Description | Participation and presentation of a talk at a Zellweger syndrome patient group support weekend |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | I attended a weekend retreat organised for families affected by Zellweger disease, presented a talk about hearing loss in Zellweger and answered questions at the formal session as well as informally during the weekend. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Public talk in Denmark |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Much interest from the 500 members of the public afterwards - over an hour answering questions after talk. Not known yet |
| Year(s) Of Engagement Activity | 2013 |
| Description | RNID supporters' visit to laboratory |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Supporters |
| Results and Impact | Ten people attended a visit to my laboratory including two RNID (charity) staff and eight supporters of the charity, to hear a talk about hearing and deafness followed by a laboratory visit with demonstrations from the team. |
| Year(s) Of Engagement Activity | 2022 |
| Description | RNID supporters' visit to laboratory |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Supporters |
| Results and Impact | Three people attended a visit to my laboratory including two RNID (charity) staff and one key supporter of the charity, to hear a talk about hearing and deafness followed by a laboratory visit with demonstrations from the team. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Radio interview |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Not known yet |
| Year(s) Of Engagement Activity | 2013 |
| Description | Telephone interviews about research |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Talking about my work on deafness using mouse models to the media. Nothing known |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010,2011,2012,2013,2014 |
| Description | Women in Science event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | Around 40 people attended an evening event on "Women in Science" organised by Action on Hearing Loss. Many were scientists supported by the charity, others were active or potential supporters. There were 4 talks and Karen Steel gave one of these. There was lively discussion afterwards, and the supporters expressed appreciation of the work done. |
| Year(s) Of Engagement Activity | 2018 |