1958 cohort-sample management
Lead Research Organisation:
University of Bristol
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
"To physically relocate DNA samples to Bristol and curate samples for 2 years. Including quality control and management of associated genotype and phenotype data .||The British 1958 birth cohort is based on all persons born in Britain during one week in March in 1958. Participants have been followed throughout their lives and biomedical information has been collected at various time points. DNA and cell line banks have been established in Bristol and at other locations. This funding will allow all DNA samples from the cohort to be held in the same laboratory in Bristol and made available to 2ry users from there, subject to oversight arrangements. Funding request includes governance and maintenance of the DNA and cell line banking facilities. The related genotype data will also be held in Bristol, including quality control data."
People |
ORCID iD |
Publications
Waterworth DM
(2010)
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
in Arteriosclerosis, thrombosis, and vascular biology
Brown J
(2009)
Observational study on variability between biobanks in the estimation of DNA concentration.
in BMC research notes
Smith NL
(2011)
Genetic predictors of fibrin D-dimer levels in healthy adults.
in Circulation
Dehghan A
(2009)
Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts.
in Circulation. Cardiovascular genetics
Soranzo N
(2010)
Common variants at 10 genomic loci influence hemoglobin A1(C) levels via glycemic and nonglycemic pathways.
in Diabetes
Anderson CA
(2009)
Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.
in Gastroenterology
Fox ER
(2011)
Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.
in Human molecular genetics
International Multiple Sclerosis Genetics Consortium (IMSGC)
(2010)
Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci.
in Human molecular genetics
Sandhu MS
(2008)
LDL-cholesterol concentrations: a genome-wide association study.
in Lancet (London, England)
Lango Allen H
(2010)
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
in Nature
Teslovich TM
(2010)
Biological, clinical and population relevance of 95 loci for blood lipids.
in Nature
Speliotes EK
(2010)
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
in Nature genetics
Newton-Cheh C
(2009)
Genome-wide association study identifies eight loci associated with blood pressure.
in Nature genetics
De Jager P
(2009)
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
in Nature Genetics
Loos RJ
(2008)
Common variants near MC4R are associated with fat mass, weight and risk of obesity.
in Nature genetics
UK IBD Genetics Consortium
(2009)
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
in Nature genetics
Franke A
(2008)
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility.
in Nature genetics
Fisher SA
(2008)
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
in Nature genetics
Franke A
(2010)
Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).
in Nature genetics
Lindgren CM
(2009)
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.
in PLoS genetics
Soranzo N
(2009)
Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.
in PLoS genetics
Obeidat M
(2011)
A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample.
in PloS one
Smith RL
(2008)
Polymorphisms in the PTPN22 region are associated with psoriasis of early onset.
in The British journal of dermatology
| Title | 1958 biomedical resource |
| Description | DNA, cell lines and biosamples collected during the 1958 biomedical sweep. Genotyping data obtained from these samples |
| Type Of Material | Biological samples |
| Year Produced | 2006 |
| Provided To Others? | Yes |
| Impact | Since the purpose of this grant was to make samples and data freely available to the scientific community for research projects we have also liaised with numerous researchers who have used the resource both in this country and internationally. Over the course of the grant there were 26 DNA sample shipments and 26 linked genotype and phenotype data requests. Since the grant ended the management of the resource was covered by finding from grant G1001799 (PI Prof Paul Burton) from 2011 to 2015 and is currently covered by grant 108439/Z/15/Z Biomedical Resources Grant, 58FORWARDS (The 1958 Birth Cohort: Fostering new Opportunities for Research via Wider Access to Reliable Data and Samples) PI Professor Paul Burton. Details of current collaborations for the 1958 biomedical resource are documented in the return for the current grant |
| URL | http://www.metadac.ac.uk/data-access-through-metadac/ |
| Title | 1958 birth cohort biomedical resource data |
| Description | Genetics and other data generated from samples collected during the biomedical sweep for the 1958 birth cohort |
| Type Of Material | Database/Collection of data |
| Year Produced | 2006 |
| Provided To Others? | Yes |
| Impact | Data has been made available for a number of international projects which results in around 70 new publications per annum. The resource supports a broad range of biomedical research, with new uses emerging with new bioscience and technological developments. which fall into the following categories (1) A national source of uncharacterised population-based controls for genomic studies (cases obtained elsewhere), primarily genotyping data from the cohort is obtained via the Wellcome Trust Case COntrol COnsortium. (2) A national source of population-based controls for non-genomic biomedical studies (cases obtained elsewhere). (3) A source of characterised cases and controls for biomedical studies. (4) A source of data and biosamples for exploring the aetiological determinants of quantitative traits. (5) A source of genotypes linked to phenotypes for exploring the aetiological architecture of common complex diseases. 6) Contribution to consortium-based analyses involving harmonization with other biobanks and co-analysis. Since the grant ended the management of the resource was covered by finding from grant G1001799 (PI Prof Paul Burton) from 2011 to 2015 and is currently covered by grant 108439/Z/15/Z Biomedical Resources Grant, 58FORWARDS (The 1958 Birth Cohort: Fostering new Opportunities for Research via Wider Access to Reliable Data and Samples) PI Professor Paul Burton. Details of current collaborations for the 1958 biomedical resource are documented in the return for the current grant |
| URL | http://www.metadac.ac.uk/data-access-through-metadac/ |
| Description | 1958 birth cohort |
| Organisation | University College London |
| Department | 1958 Birth Cohort/National Child Development Study |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | This grant was a resource grant for the 1958 and as such the samples and data have been used by many users. Since the grant ended the management of the resource was covered by finding from grant G1001799 (PI Prof Paul Burton) from 2011 to 2015 and is currently covered by grant 108439/Z/15/Z Biomedical Resources Grant, 58FORWARDS (The 1958 Birth Cohort: Fostering new Opportunities for Research via Wider Access to Reliable Data and Samples) PI Professor Paul Burton. Details of current collaborations for the 1958 biomedical resource are documented in the return for the current grant |
| Collaborator Contribution | see above |
| Impact | see above |
| Start Year | 2006 |
| Description | 1958 participants |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Research findings from the study are publicised to participants via the study team responsible for maintaining contact with the cohort at the Institute of Education, University College London. There is a participant website (http://www.ncds.info/default.asp) which includes details of press releases and media coverage related to the study. Encourages participation in future data collection exercises |
| Year(s) Of Engagement Activity | Pre-2006,2006,2007,2008,2009,2010,2011,2012,2013,2014,2015,2016 |
| URL | http://www.cls.ioe.ac.uk/page.aspx?&sitesectionid=724&sitesectiontitle=National+Child+Development+St... |