Centre for Musculoskeletal Ageing Research

Lead Research Organisation: University of Birmingham
Department Name: Immunity and Infection

Abstract

Ageing is a complex process that results in the reduced functioning of most of the body's organ systems, with the musculoskeletal system (muscle, bone, tendon and cartilage) significantly affected. The musculoskeletal system is compromised not only by loss of muscle, bone and cartilage with age, but also by the decline in function of the nervous system which results in reduced control of movement and balance. Ageing is also often accompanied by weight gain which puts further strain on joints and contributes to erosion of cartilage and bone, increasing the chances of developing Osteoarthritis (OA). Importantly both ageing and obesity decrease physical activity levels and increase the level of inflammation in the body and alter hormone balance, all of which affect the ability of the body to maintain the musculoskeletal system. Therefore increased physical activity and interventions that are able to reduce inflammation and correct age and obesity related hormone changes, offer a way forward for delaying age-related changes in the musculoskeletal system.
Objectives:
The objective is to set up a Centre of Excellence in Musculoskeletal Ageing Research by integrating and expanding the complementary research and postgraduate training activity of the two leading Midlands based Universities, Birmingham and Nottingham, together with their associated NHS hospital trusts. The Centre will also establish a unique technical facility for measuring human muscle, tendon and bone metabolism that will provide a valuable resource for the UK research community. The Centre's over-arching research aim is to understand how ageing results in loss of musculoskeletal function and to use this knowledge to intervene and minimise age-related musculoskeletal decline and disease. The major focus of these interventions will be exercise and diet.

Clinical benefits:
The potential clinical benefits of the research carried out by the Centre are significant as age-related loss of musculoskeletal function has major clinical consequences, including increased risk of falls and fracture (hip and wrist), OA and pain. 1 in 3 older adults fall each year and for 76,000 patients this results in hip fracture. Hip fracture is associated with increased morbidity, loss of independence and the 1 year mortality figure for hip fracture is 22%. There are 6 million people with OA in the UK1, a painful condition which reduces the ability to work and has a significant impact upon quality of life. OA is exacerbated by obesity and there are currently no treatments other than pain remediation.

Research questions:
1. What are the key factors driving ageing of the component tissues of the musculoskeletal system, both individually and as an integrated system? This will include the role of genetics and lifestyle; the role of inflammation, physical activity and changes in tissue steroid hormones; age-related loss of neuromuscular function and its contribution to reduced coordination, balance and reduced ability to perform complex motor tasks such as driving.
2. Assessment of interventions to improve musculoskeletal function in old age. It is well established that physical activity reduces the loss of muscle and bone mass with age. In young subjects dietary supplements can increase muscle mass, improve metabolism and reduce inflammation, but efficacy in older adults is largely unknown. The Centre will determine optimal exercise and nutritional supplementation regimes for musculoskeletal maintenance in older adults, both healthy and frail. Interventions will also include pharmacological approaches aimed at reducing inflammation and adjusting hormone balance in favour of musculoskeletal maintenance.
3. Identifying psychological and environmental (practical) barriers to increased physical activity or weight loss in older adults will be a key question addressed by the Centre, with the aim of developing interventions that will be practical and attractive to older adults.

Technical Summary

Centre research will be carried out almost entirely in humans, with animal studies limited to testing of new hypotheses or treatments.
1. Understanding the processes underlying the loss of muscle, bone and cartilage with age, the role played by inflammation, metabolism and altered hormones and the efficacy of a range of methods for improving musculoskeletal function, will be addressed using a variety of methods in healthy older adults. This will include:
a. Analysis of new and stored muscle biopsy material, including samples from a 20 year longitudinal tissue bank;
b. Studies of muscle function and metabolism in older humans during exercise;
c. Computer modelling of these data to understand the key factors driving musculoskeletal decline and revealing where interventions should be targeted to gain maximum benefit;
d. Studies of neuromuscular function using lab based analysis of feedback from the brain to the muscles and novel blue-tooth technology to analyse gait in volunteers whilst carrying out their normal activities.

2. Intervention studies to improve musculoskeletal function will include:
a. Assessing the efficacy of different diet and exercise regimes. To improve adherence to these protocols, different motivational approaches will be assessed in older volunteers.
b. Assessing the benefits of novel drugs;
c. Virtual reality and augmented muscle activation (electromagnetic stimulation) to improve neuromuscular performance.

3. Overcoming barriers to lifestyle change adoption.
Effecting long term lifestyle changes remains a significant health challenge. A unique feature of this Centre will be close working with psychologists in order to understand and optimise motivational processes linked to increased physical activity or weight loss. The focus will be on development, implementation and evaluation of theory-based psychological interventions in older adults, initially community dwelling but eventually extending to residential home settings.

Planned Impact

370,000 older adults fall each year in the UK, 76,000 of these falls result in hip fracture and this is predicted to rise to 120,000 by 2015. There are also 6 million UK patients with osteoarthritis. These are just two examples of the consequences of unsuccessful musculoskeletal ageing. The proposed Centre for Musculoskeletal Ageing Research will improve understanding of the loss of musculoskeletal mass and function with age. Crucially, it will use this knowledge to develop and validate evidence-based interventions, with a focus on physical activity and diet, for use in the community as well as care or residential homes, which will attenuate age-related musculoskeletal frailty.
The potential beneficiaries and areas of impact of the research include:
a. Older individuals and their carers will benefit, through extended independence and good health of the older individual. In the case of falls, hip fracture is a leading cause of admission into residential care as well as leading to increased mortality. Relatives lose out economically through reduced time spent at work whilst caring for the injured relative. Maintaining good musculoskeletal function will help to prevent primary and secondary falls and reduce the chance of hip fracture. The two most significant risk factors for Osteoarthritis are age and obesity and OA has a significant economic impact through costs to the NHS and for loss of productivity for the patient. Research in the Centre will develop interventions to optimise musculoskeletal function into old age, helping to prevent the incidence of both conditions and influencing health policy in the UK. Maintained physical vitality and independence will also have broader health benefits, contributing to maintenance of well being.
b. UK economy. According to ARUKs 2008 Arthritis in the UK factsheet 10 million working days were lost through musculoskeletal conditions in 2006/7 and the cost to the NHS of poor musculoskeletal health is £5.7 billion per annum. mainaining musculoskeletal function in old age will thus have impact on the cost of health care in the UK and beyond;
c. Pharmaceutical and nutraceutical industry. The interventions tested in the Centre will include pharmacological interventions and will potentially extend the remit of existing drugs or those in development by big pharma. Equally interventions involving nutraceuticals should provide a strong evidence base for their use in older adults, thus helping this industry.
d.Public and private organisations providing advice and services to older adults (NHS, AGE UK, BUPA), will benefit through the availability of a strong evidence base for health policy or interventions (lifestyle, nutraceutical or pharmacology based). Centre research will also include a strong motivational psychology element, assessing which lifestyle intervention delivery modes achieve greater adherence in older adults;
e. Understanding of musculoskeletal development and ageing and the impact of exercise and nutrition, will be improved and will increase the knowledge ase and research and training capacity in a key area in the UK.

Publications

10 25 50

 
Description ARUK document. Musculoskeletal health: a public health approach
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
URL http://www.arthritisresearchuk.org/~/media/Files/Policy%20files/2014/public-health-guide.ashx
 
Description ARUK: policy statement on physical activity and musculoskeletal decline
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
 
Description Academy of Medical Sciences Report on Influencing Healthy Ageing Trajectories
Geographic Reach National 
Policy Influence Type Participation in a national consultation
URL https://acmedsci.ac.uk/more/news/trajectories-of-ageing-balancing-longevity-and-health
 
Description Care Home staff training workshops
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Contribution to MRC-Arthritis Research Centre for Musculoskeletal Ageing (CMAR) response to The House of Lords Science and Technology Committee inquiry into Ageing: Science, Technology and Healthy Living
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description Healthy Ageing Policy Commission Report
Geographic Reach National 
Policy Influence Type Participation in a national consultation
URL http://www.birmingham.ac.uk/research/impact/policy-commissions/healthy-ageing/report.aspx
 
Description Move It or Lose It Training Programme
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
Impact The MIOLI Training programme
 
Description Participation in a strategy setting workshop on age-related physical decline by the Physiology Society
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description Preventing frailty workshops
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
URL https://www.staffordshire.gov.uk/health/PublicHealth/Annual-Public-Health-Report-2014.pdf
 
Description A Chair Based Exercise (CBE) Programme for Older People in Community Settings: A Feasibility Study (Gladman, J)
Amount £220,623 (GBP)
Funding ID PB-PG-0613-31012 
Organisation National Institute for Health Research 
Department Research for Patient Benefit
Sector Public
Country United Kingdom
Start  
 
Description A Cluster-randomised controlled trial of a school-based Physical Activity Intervention in At-Risk Communities (Lonsdale C as PI)
Amount £484,000 (GBP)
Organisation Australian Research Council 
Sector Public
Country Australia
Start 01/2013 
End 12/2015
 
Description A psychological intervention fostering cardiovascular fitness, autonomous motivation ad physical activity in rheumatoid arthritis patients
Amount £407,371 (GBP)
Organisation Medical Research Council (MRC) 
Department National Prevention Research Initiative (NPRI)
Sector Charity/Non Profit
Country United Kingdom
Start 04/2010 
End 03/2013
 
Description Action330: Promoting children's physical activity via enhanced after-school leadership
Amount £467,000 (GBP)
Funding ID MR/J000191/1 
Organisation Medical Research Council (MRC) 
Department National Prevention Research Initiative (NPRI)
Sector Charity/Non Profit
Country United Kingdom
Start 04/2012 
End 09/2014
 
Description Activating mitochondrial biogenesis in skeletal muscle through repression of the acetyltransferase GCN5.
Amount £523,599 (GBP)
Funding ID BB/L023547/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 09/2014 
End 09/2017
 
Description Aerobic exercise training in the overnight fasted state: a practical strategy to augment intramyocellular triglyceride turnover in obesity? (Wallis, G)
Amount $46,698 (USD)
Organisation Allen Foundation USA 
Sector Charity/Non Profit
Country United States
Start  
 
Description Application of deuterated water (2H2O) to define the etiology of musculoskeletal decline in ageing and the efficacy of nutritional supplementation (Smith, K)
Amount £198,000 (GBP)
Funding ID R264/1112 
Organisation The Dunhill Medical Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Arthritis Research UK Centre for Sport, Exercise and OA
Amount £2,999,582 (GBP)
Organisation Versus Arthritis 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description BBSRC - Industrial Case - Revealing novel nutritional strategies to modulate fuel metabolism (Wallis, G)
Amount £124,173 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start  
 
Description BGS Falls and Bones Section Research Grant
Amount £9,921 (GBP)
Organisation British Geriatrics Society (BGS) 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2018 
End 12/2018
 
Description BY-BAND: Gastric BYpass or adjustable gastric BANDing surgery to treat morbid obesity: a multi-centre randomised controlled trial
Amount £2,874,696 (GBP)
Funding ID HTA/09/127/53 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 09/2011 
End 08/2019
 
Description Balance and the Mind (Harwood, R)
Amount £100,000 (GBP)
Funding ID RP-DG-0611-10013 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start  
 
Description Can FcRL-4 expression by B cells be used as a biomarker for the early diagnosis of rheumatoid arthritis? (Scheel-Toellner, D)
Amount £99,174 (GBP)
Organisation Medical Research Council (MRC) 
Department MRC Confidence in Concept Scheme
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Can carnitine supplementation modulate fat oxidation and weight loss during energy restriction and exercise training in obesity? (Stephens, F)
Amount £54,257 (GBP)
Organisation East Midlands Medilink 
Department Healthcare & Bioscience iNet
Sector Public
Country United Kingdom
Start  
 
Description Central and peripheral actions of FGF21 in promoting fat catabolism (Ebling)
Amount £399,161 (GBP)
Funding ID BB/M001555/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start  
 
Description Centre for Doctoral Training in Physical Sciences for Health (Sci-Phy-4-Health) with the topic themes of Ageing, trauma and cardiovascular disease
Amount £3,500,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start  
 
Description Cerebellar-cortical interactions in health, aging and disease
Amount £1,322,400 (GBP)
Funding ID 087554 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Characterisation of the pig as a model of musculoskeletal ageing (Jones SW)
Amount £59,700 (GBP)
Organisation University of Birmingham 
Sector Academic/University
Country United Kingdom
Start 09/2013 
End 09/2016
 
Description Cherries, a treatment for Sarcopenia? (Smith, K)
Amount $50,000 (USD)
Organisation Cherry Marketing Institute 
Sector Private
Country United States
Start  
 
Description Clinical efficacy of functional strength training for upper limb motor recovery early after stroke: neural correlates and prognostic indicators
Amount £145,000 (GBP)
Funding ID MC_PC_12034 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start  
 
Description CoDyCo: Whole-body Compliant Dynamical Contacts in Cognitive Humanoids
Amount € 3,000,000 (EUR)
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start  
 
Description CogLaboration: Successful Real World Human-Robot Collaboration.
Amount € 500,000 (EUR)
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start  
 
Description CogWatch: Cognitive Rehabilitation of Apraxia and Action Disorganisation
Amount € 1,206,000 (EUR)
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start  
 
Description Community-based Prevention of Diabetes (ComPoD): A randomised trial with a waiting list control group to evaluate the effectiveness and cost-effectiveness of a third sector led, community-based diabetes prevention programme.
Amount £88,072 (GBP)
Organisation National Institute for Health Research 
Department NIHR School for Public Health Research
Sector Academic/University
Country United Kingdom
Start 07/2014 
End 06/2016
 
Description Creating an in vitro model of pathogenic ossification to explore methods for dispersion
Amount £100,000 (GBP)
Funding ID NC/L001403/1 
Organisation National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2014 
End 06/2017
 
Description De-convoluting the visfatin signalling pathway in OA
Amount £4,999 (GBP)
Organisation Royal Opera House 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2014 
End 07/2015
 
Description Defining the benchmark for optimal human ageing
Amount £211,000 (GBP)
Organisation BUPA 
Department BUPA Foundation
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Determinants and significance of the inter-individual variability in fat oxidation during exercise (Wallis, G)
Amount £59,700 (GBP)
Organisation University of Birmingham 
Sector Academic/University
Country United Kingdom
Start  
 
Description Determination of the time-course of development of insulin resistance, and associated molecular and muscular adaptations, during prolonged bed-rest.
Amount £602,301 (GBP)
Funding ID BB/K019104/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2015 
End 12/2018
 
Description Developing fMRI to analyse CNS response to exercise
Amount £70,000 (GBP)
Organisation University of Nottingham 
Sector Academic/University
Country United Kingdom
Start 10/2013 
 
Description Developing new methods for dispersing heterotopic ossification (Grover, L)
Amount £100,000 (GBP)
Organisation Ministry of Defence (MOD) 
Sector Public
Country United Kingdom
Start  
 
Description Development of a culturally adapted weight management programme for children of Pakistani and Bangladeshi origin
Amount £543,795 (GBP)
Funding ID HTA/12/137/05 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 09/2014 
End 02/2017
 
Description Development of a non-invasive stable isotope-based sarcopenia diagnostic
Amount £50,000 (GBP)
Organisation Medical Research Council (MRC) 
Department MRC Confidence in Concept Scheme
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Development of a non-invasive stable isotope-based sarcopenia diagnostic (Atherton, P)
Amount £50,000 (GBP)
Organisation Medical Research Council (MRC) 
Department MRC Confidence in Concept Scheme
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Development of multivalent tracer-based diagnostics of muscle mass, muscle synthesis and muscle breakdown for application to identifying, and treating sarcopenia (Gladman, J)
Amount £84,813 (GBP)
Organisation Abbeyfield 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2016 
End 01/2019
 
Description Diabetes - PREVIEW - FP7 (Macdonald, I)
Amount € 1,086,555 (EUR)
Funding ID 312057 
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start  
 
Description Does obesity exacerbate age-related muscle anabolic resistance? (Breen, L)
Amount £15,438 (GBP)
Organisation Wellcome Trust 
Department Wellcome Trust Institutional Strategic Support Fund
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description ERC Starting Grant (Galea, J)
Amount € 1,500,000 (EUR)
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 10/2015 
End 09/2020
 
Description EURO TEAM biomarkers of ageing and RA
Amount € 1,245,220 (EUR)
Funding ID 305549 
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start  
 
Description East Midlands AHSN Frail Older People theme (Gladman, J)
Amount £346,686 (GBP)
Organisation East Midlands Academic Health Science Network 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Effect of prolonged inactivity upon vestibular control of balance (Reynolds, R)
Amount £29,000 (GBP)
Funding ID BB/P017185/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start  
 
Description Empowering PE teachers in Wales to promote secondary students' motivation for physical activity engagement
Amount £95,000 (GBP)
Organisation Sport Wales 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2013 
End 06/2015
 
Description Examining diet and physical activity behaviours amongst older migrant women through the lens of superdiversity
Amount £1,000 (GBP)
Organisation University of Birmingham 
Department Institute for Research into Superdiversity (IRiS)
Sector Academic/University
Country United Kingdom
Start 09/2013 
End 09/2014
 
Description Exercise as Medicine PhD Studentship - University of Birmingham, School of Sport, Exercise and Rehabilitation Science (Philp, A)
Amount £57,089 (GBP)
Organisation University of Birmingham 
Sector Academic/University
Country United Kingdom
Start  
 
Description FEMS to reduce sarcopenia during bed rest
Amount £100,000 (GBP)
Organisation National Institute for Health Research 
Department NIHR Imperial Biomedical Research Centre
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description FOREUM
Amount € 599,881 (EUR)
Organisation Foreum 
Sector Charity/Non Profit
Country Switzerland
Start 03/2018 
End 03/2021
 
Description Factors determining partitioning of fat metabolism in human skeletal muscle (Stephens, F)
Amount £43,929 (GBP)
Funding ID 1366278 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start  
 
Description Feasibility and metabolic effects of carbohydrate loading in patients with fragility hip fracture - a randomized double blind pilot study
Amount £64,310 (GBP)
Funding ID NIAA 2012(1); BJA/RCOA grant 
Organisation National Institute of Academic Anaesthesia 
Sector Academic/University
Country United Kingdom
Start  
 
Description GLUCOTOX (Gareth Lavery for Dr Thomas Solomon)
Amount € 187,000 (EUR)
Funding ID 656775 
Organisation Marie Sklodowska-Curie Actions 
Sector Charity/Non Profit
Country Global
Start 07/2015 
End 06/2017
 
Description Global mRNA and microRNA changes during exercise rehabilitation in COP
Amount £193,105 (GBP)
Organisation Novartis 
Sector Private
Country Global
Start  
 
Description Healthy Ageing in Residential Places (HARP)
Amount £11,623 (GBP)
Funding ID ES/K010964/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 03/2013 
End 06/2015
 
Description Heterotopic ossification tissue engineering (Grover, L)
Amount £90,000 (GBP)
Organisation Royal Centre for Defence Medicine (RCDM) 
Sector Hospitals
Country United Kingdom
Start 06/2014 
End 12/2015
 
Description High Intensity Interval Training in older adults.
Amount € 294,219 (EUR)
Organisation Marie Sklodowska-Curie Actions 
Sector Charity/Non Profit
Country Global
Start  
 
Description High-resolution metabolic profiling - new approaches to understand metabolic disease (Philp, A)
Amount £602,889 (GBP)
Organisation University of Birmingham 
Sector Academic/University
Country United Kingdom
Start  
 
Description Horizon 2020 International Training Network - PANINI - Physical Activity and Nutrition Influences iN Ageing (Phillips, A)
Amount € 819,863 (EUR)
Funding ID 675003 
Organisation European Commission 
Department Horizon 2020
Sector Public
Country European Union (EU)
Start  
 
Description How does lifelong exercise preserve muscle metabolic health? (Breen, L)
Amount £57,089 (GBP)
Organisation University of Birmingham 
Sector Academic/University
Country United Kingdom
Start 10/2015 
End 09/2018
 
Description Identification of OA cartilage disease specific lincRNAs
Amount £19,200 (GBP)
Organisation Wellcome Trust 
Department Wellcome Trust Institutional Strategic Support Fund
Sector Charity/Non Profit
Country United Kingdom
Start 02/2014 
End 02/2015
 
Description Identification of OA cartilage disease specific lincRNAs
Amount £19,200 (GBP)
Organisation Wellcome Trust 
Department Wellcome Trust Institutional Strategic Support Fund
Sector Charity/Non Profit
Country United Kingdom
Start 02/2014 
End 02/2015
 
Description Identification of OA cartilage disease specific lincRNAs
Amount £5,000 (GBP)
Organisation University of Birmingham 
Department Postgraduate Research Development Fund
Sector Academic/University
Country United Kingdom
Start 12/2013 
End 12/2014
 
Description Identification of the receptor for the adipokine visfatin (Jones SW)
Amount £10,500 (GBP)
Organisation Wellcome Trust 
Department Wellcome Trust Institutional Strategic Support Fund
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Identifying novel nutrient regulators of skeletal muscle metabolism (Philp, A)
Amount £94,878 (GBP)
Organisation Lucozade Ribena Suntory 
Sector Private
Country United Kingdom
Start  
 
Description Improving motor learning and retention in Parkinson's disease through reward (Jenkinson, N)
Amount £83,919 (GBP)
Funding ID H-1402 
Organisation Parkinson's UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Improving skeletal muscle insulin sensitivity in healthy ageing.
Amount £202,166 (GBP)
Funding ID R211/0711 
Organisation The Dunhill Medical Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2012 
End 12/2014
 
Description Increasing fat oxidation and body fat loss in obesity with L-carnitine, exercise and caloric restriction.
Amount £54,257 (GBP)
Organisation East Midlands Medilink 
Sector Private
Country United Kingdom
Start 04/2013 
End 03/2015
 
Description Increasing skeletal muscle carnitine content to improve glycaemic control in individuals recently diagnosed with Type 2 diabetes
Amount £192,243 (GBP)
Funding ID 13/0004659 
Organisation Diabetes UK 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2014 
End 06/2016
 
Description Incretin Effect of Amino Acids (AA) and GLP-1 on Muscle Microvascular recruitment and metabolism in healthy volunteers
Amount £115,000 (GBP)
Organisation Royal Derby Hospital 
Department Research and Development Department
Sector Hospitals
Country United Kingdom
Start  
 
Description Influence of combined vitamin D supplementation and resistance exercise training on musculoskeletal health in frail older men and women (EXVITD)
Amount £94,160 (GBP)
Organisation Royal Osteoporosis Society 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2015 
End 01/2019
 
Description Influence of resistance training and hypocaloric restriction in older adults with knee OA
Amount £37,707 (GBP)
Organisation King Saud University 
Sector Academic/University
Country Saudi Arabia
Start 09/2014 
 
Description Integrating innovative technologies for genotyping and phenotyping in stratified
Amount £7,178,789 (GBP)
Funding ID MR/M009157/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2015 
End 03/2017
 
Description Investigating the muscle anabolic properties of phosphatidic acid in ageing
Amount £20,000 (GBP)
Organisation Abbeyfield 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Investigating the muscle anabolic properties of phosphatidic acid in ageing
Amount £25,595 (GBP)
Organisation Wellcome Trust 
Department Wellcome Trust Pump Prime Award
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Investigation into the effect of Vetadine wash on bone tissue
Amount £2,300 (GBP)
Organisation British Scoliosis Research Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2014 
End 10/2015
 
Description MNTRF
Amount £10,000 (GBP)
Organisation Midland Neuroscience Teaching and Research Fund 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2017 
End 01/2018
 
Description Mesenchymal Glucocorticoid Metabolism: Shaping Articular and Extra-articular Manifestations of Rheumatoid Arthritis via Wnt Mediated Pathways (Hardy, R)
Amount £437,000 (GBP)
Funding ID 20843 
Organisation Versus Arthritis 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Modulation of muscle protein synthesis by essential amino acids: exploring the "muscle-full" phenomenon in humans
Amount £150,000 (GBP)
Organisation Ajinomoto 
Sector Private
Country Japan
Start  
 
Description More of the Same Is Not Enough: New Directions in Ageing and Physical Activity
Amount £30,000 (GBP)
Funding ID ES/M001709/1 
Organisation Economic and Social Research Council 
Department ESRC Seminar Series
Sector Academic/University
Country United Kingdom
Start 11/2014 
End 10/2017
 
Description NIHR BRC in Inflammation
Amount £12,800,000 (GBP)
Organisation National Institute for Health Research 
Department NIHR Biomedical Research Centre
Sector Public
Country United Kingdom
Start 04/2017 
End 03/2022
 
Description NIHR Centre for Surgical Reconstruction and Microbiology
Amount £10,000,000 (GBP)
Organisation National Institute for Health Research 
Department NIHR Centre for Surgical Reconstruction and Microbiology
Sector Academic/University
Country United Kingdom
Start 07/2016 
End 06/2021
 
Description NIHR Nottingham BRC
Amount £23,000,000 (GBP)
Organisation National Institute for Health Research 
Department NIHR Biomedical Research Centre
Sector Public
Country United Kingdom
Start 04/2017 
End 03/2022
 
Description Novel Diagnostics and Biomarkers for early identification of chronic inflammatory joint diseases (D¬BOARD)
Amount € 1,802,050 (EUR)
Funding ID 305815 
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 06/2012 
End 06/2017
 
Description Novel Implantable Devices Manufactured with Embedded Therapeutics (Grover, L)
Amount £668,000 (GBP)
Funding ID EP/L020815/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 07/2014 
End 06/2017
 
Description Novel implant design and manufacture with embedded therapeutics (Shepard, D)
Amount £534,061 (GBP)
Funding ID EP/L020815/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start  
 
Description OPAL-PLUS: How have you been? A 3-year follow-up of participants from Project OPAL to assess changes in physical function, physical activity and mental well-being
Amount £86,294 (GBP)
Funding ID R200/0511 
Organisation The Dunhill Medical Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2011 
End 02/2013
 
Description Obesity Wars: Fitness versus Fatness - Public Engagement Funding
Amount £5,000 (GBP)
Organisation Physiological Society 
Sector Charity/Non Profit
Country Global
Start 04/2014 
End 05/2014
 
Description PHD Studentship Andrew Hale
Amount £41,178 (GBP)
Organisation Versus Arthritis 
Department Arthritis Research UK Centre for Musculoskeletal Ageing Research
Sector Academic/University
Country United Kingdom
Start 10/2013 
End 09/2016
 
Description PHD Studentship Mhairi Macfadyen
Amount £41,178 (GBP)
Organisation Versus Arthritis 
Department Arthritis Research UK Centre for Musculoskeletal Ageing Research
Sector Academic/University
Country United Kingdom
Start 10/2013 
End 09/2016
 
Description PHISICAL (Gladman, J)
Amount £250,000 (GBP)
Organisation National Institute for Health Research 
Department NIHR CLAHRC for East Midlands
Sector Public
Country United Kingdom
Start  
 
Description PRIISM-HD- Pathways Regulating Intramyocellular Insulin Sensitivity and Metabolism in Health and Disease (Gareth Lavery for Dr Stuart Morgan).
Amount € 186,000 (EUR)
Funding ID 659571 
Organisation Marie Sklodowska-Curie Actions 
Sector Charity/Non Profit
Country Global
Start 07/2015 
End 06/2017
 
Description PROACTIV: PaRental influences On physical ACTIVity and screen viewing in young children
Amount £242,101 (GBP)
Funding ID PG/11/51/28986 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2012 
End 08/2014
 
Description Performance-based selective training for robot-mediated upper limb motor learning and stroke rehabilitation
Amount £500,000 (GBP)
Funding ID MR/J012610/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description Periodontal inflammation: contribution of the ageing immune system and consequences for health
Amount £120,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description PhD Studentship - Archontissa Kanavaki
Amount £41,178 (GBP)
Organisation Versus Arthritis 
Department Arthritis Research UK Centre for Musculoskeletal Ageing Research
Sector Academic/University
Country United Kingdom
Start 10/2014 
End 09/2017
 
Description PhD Studentship Daniel Craig
Amount £41,178 (GBP)
Organisation Versus Arthritis 
Department Arthritis Research UK Centre for Musculoskeletal Ageing Research
Sector Academic/University
Country United Kingdom
Start 10/2014 
End 09/2017
 
Description PhD Studentship Danielle Thomas
Amount £41,178 (GBP)
Organisation Versus Arthritis 
Department Arthritis Research UK Centre for Musculoskeletal Ageing Research
Sector Academic/University
Country United Kingdom
Start 10/2013 
End 09/2016
 
Description PhD Studentship Nick Kitchen
Amount £41,178 (GBP)
Organisation Versus Arthritis 
Department Arthritis Research UK Centre for Musculoskeletal Ageing Research
Sector Academic/University
Country United Kingdom
Start 10/2013 
End 09/2016
 
Description PhD Studentship Peter Davidsen
Amount £41,178 (GBP)
Organisation Versus Arthritis 
Department Arthritis Research UK Centre for Musculoskeletal Ageing Research
Sector Academic/University
Country United Kingdom
Start 10/2013 
End 09/2016
 
Description PhD Studentship Samuel Jones
Amount £41,178 (GBP)
Organisation Versus Arthritis 
Department Arthritis Research UK Centre for Musculoskeletal Ageing Research
Sector Academic/University
Country United Kingdom
Start 10/2014 
End 09/2017
 
Description PhD Studentship Simon Franklin
Amount £41,178 (GBP)
Organisation Versus Arthritis 
Department Arthritis Research UK Centre for Musculoskeletal Ageing Research
Sector Academic/University
Country United Kingdom
Start 10/2013 
End 09/2016
 
Description PhD Studentship Stuart Mackenzie
Amount £41,178 (GBP)
Organisation Age UK 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2014 
End 09/2017
 
Description PhD studentship
Amount £94,160 (GBP)
Funding ID 109/ 319 
Organisation Royal Osteoporosis Society 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2015 
End 12/2019
 
Description Phase shifts in metronome-cued training of hemiparetic gait
Amount £150,000 (GBP)
Funding ID TSA2009/06 
Organisation Stroke Association 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Post-doctoral Research Fellowship - Mechanisms of muscle wasting in advanced chronic kidney disease (Philp, A for Dr Emma Watson)
Amount £200,960 (GBP)
Funding ID PDF2/2015 
Organisation Kidney Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Probing light touch contributions to elderly balance
Amount £21,000 (GBP)
Funding ID BB/I026049/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start  
 
Description Project ACE: Active, Connected and Engaged Neighbourhoods
Amount £248,897 (GBP)
Funding ID G1001864 
Organisation Medical Research Council (MRC) 
Department Lifelong Health and Wellbeing (LLHW)
Sector Academic/University
Country United Kingdom
Start 12/2011 
End 11/2013
 
Description Project grant
Amount £153,717 (GBP)
Funding ID R353/ 0514 
Organisation The Dunhill Medical Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2015 
End 09/2018
 
Description Promoting Activity, Independence and Stability in Early Dementia (Gladman, J)
Amount £2,746,451 (GBP)
Funding ID RP-PG-0614-20007 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start  
 
Description RNAseq transcriptome profiling to identify candidate lincRNAs that mediate inflammation in the osteoarthritic joint
Amount £13,500 (GBP)
Funding ID RG130130 
Organisation The Royal Society 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2013 
End 10/2014
 
Description Reducing the burden of COPD by targeting skeletal muscle mass function
Amount £400,000 (GBP)
Funding ID G1001362 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description Responsive mode
Amount £1,100,000 (GBP)
Funding ID BB/R003971/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2018 
End 12/2020
 
Description Rheumatoid Arthritis and Periodontal Inflammatory Disease (RAPID)
Amount £591,677 (GBP)
Funding ID 290246 
Organisation Marie Sklodowska-Curie Actions 
Department Initial Training Networks (ITN)
Sector Charity/Non Profit
Country Global
Start  
 
Description Royal Society Leverhulme Senior Research Fellowship
Amount £54,000 (GBP)
Organisation The Royal Society 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2017 
End 09/2019
 
Description Sensory Integration and Motor Adaptation
Amount £8,400 (GBP)
Organisation The Royal Society 
Department International Exchanges Scheme
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Sensory role of Muscle for balance (Reynolds, R)
Amount £321,000 (GBP)
Funding ID BB/L02103X/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start  
 
Description Skeletal muscle protein metabolism and insulin sensitivity in overweight individuals: Effects of meals with various fatty acid compositions (Tsintzas, K)
Amount £19,340 (GBP)
Organisation The Diabetes Research & Wellness Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Sparking Impact. Development of non-invasive stable isotope-based diagnostic of muscle status (Atherton, P)
Amount £25,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start  
 
Description Spinal implant design (Shepard, D)
Amount £910,559 (GBP)
Funding ID 604935 
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start  
 
Description Strategies to combat sarcopenia
Amount £40,000 (GBP)
Organisation São Paulo Research Foundation (FAPESP) 
Sector Public
Country Brazil
Start 12/2014 
 
Description Structural and metabolic determinants of sarcopenia and efficacy of concentric vs. eccentric exercise training: a novel temporospatial approach
Amount £472,985 (GBP)
Funding ID BB/K019104/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start  
 
Description Structural, Mechanical, and Metabolic Responses to Functional Overload of the" Muscle-Tendon Unit" in Young and Older Individuals (Wallis, G)
Amount £69,735 (GBP)
Funding ID 1397964 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description Studies in Bioengineering and Medical Informatics (Shepard, D)
Amount £86,026 (GBP)
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start  
 
Description Study of acute muscle protein metabolism in healthy older subjects.
Amount £531,000 (GBP)
Organisation Abbott 
Department Abbott Nutrition
Sector Private
Country United States
Start  
 
Description The REACT (Retirement in ACTion) study (Thompson, J)
Amount £298,612 (GBP)
Funding ID PHR/13/164/51 
Organisation National Institute for Health Research 
Department Public Health Research (PHR) Programme
Sector Charity/Non Profit
Country United Kingdom
Start 09/2015 
End 02/2020
 
Description The acute effects of sitting time on physiological and psychological function on older adults
Amount £153,717 (GBP)
Funding ID R353/0514 
Organisation The Dunhill Medical Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description The cross-talk between innate immune cells, adipose tissue and skeletal muscle and its role in sarcopenic obesity
Amount £90,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2014 
End 10/2017
 
Description The efficacy of leucine enriched-EAA supplements vs. whey protein in the modulation of muscle protein synthesis, albumin synthesis and leg/ muscle blood flow in older women
Amount £150,000 (GBP)
Organisation Ajinomoto 
Sector Private
Country Japan
Start  
 
Description The functional role of adipose secreted cytokines (Adipokines) in mediating pathological changes in the osteoarthritic joint (Jones SW)
Amount £70,000 (GBP)
Organisation University of Birmingham 
Sector Academic/University
Country United Kingdom
Start  
 
Description The impact of high load eccentric exercise on muscle functional loss and recovery and muscle protein synthetic rates and in healthy, young male volunteers unaccustomed to exercise training
Amount £376,727 (GBP)
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start  
 
Description The impact of trauma and related inflammation on skeletal muscle fuel and protein metabolism.
Amount £275,685 (GBP)
Organisation Defence Science & Technology Laboratory (DSTL) 
Sector Public
Country United Kingdom
Start 02/2017 
End 07/2018
 
Description The metabolomic study of healthy ageing applying dried blood and urine spot collection (Dunn, W)
Amount £91,000 (GBP)
Funding ID BB/M015890/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start  
 
Description The regulation of NAD+ metabolism in skeletal muscle during ageing and exercise
Amount £1,600,000 (GBP)
Funding ID 104612/Z/14/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2014 
End 10/2019
 
Description The role of LincRNAs in mediating inflammation within the OA joint
Amount £227,894 (GBP)
Funding ID R316/1113 
Organisation The Dunhill Medical Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2014 
End 05/2015
 
Description The role of LincRNAs in mediating inflammation within the OA joint
Amount £13,500 (GBP)
Organisation The Royal Society 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2013 
End 12/2014
 
Description Transcriptional profiling of mRNA and microRNA changes during resistance exercise training in COPD
Amount £193,105 (GBP)
Organisation Novartis 
Sector Private
Country Global
Start  
 
Description Translating improved human metabolic function in the controlled laboratory setting into improved function in the general population
Amount £59,730 (GBP)
Organisation Medical Research Council (MRC) 
Department MRC Confidence in Concept Scheme
Sector Charity/Non Profit
Country United Kingdom
Start 02/2013 
End 11/2013
 
Description Translational magnetic resonance imaging centre
Amount £9,370,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description UNIFY, A focussed on the treatment of fracture non-union (Grover, L)
Amount £160,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 04/2014 
End 03/2017
 
Description Uncoupling obesity and osteoarthritis
Amount £277,000 (GBP)
Organisation BUPA 
Department BUPA Foundation
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Understanding metabolic changes in different age groups associated with exercise-induced benefits to
Amount £11,800 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2014 
End 11/2014
 
Description Understanding the driving factors of age related muscle anabolic resistance
Amount £59,700 (GBP)
Organisation University of Birmingham 
Sector Academic/University
Country United Kingdom
Start 10/2013 
End 10/2016
 
Description University of Birmingham Studentship - Ashleigh Evans - The role of adipokines in mediating OA pathology
Amount £59,700 (GBP)
Organisation University of Birmingham 
Sector Academic/University
Country United Kingdom
Start 09/2013 
End 09/2016
 
Description Using biological variation to uncover mechanisms regulating human muscle atrophy (Idris, I)
Amount £120,000 (GBP)
Organisation Royal Derby Hospital 
Sector Hospitals
Country United Kingdom
Start  
 
Description Wellcome Trust for a Senior Research Fellow in Basic Biomedical Science - regulation of Muscle NAD+ metabolism in ageing and exercise (Lavery G)
Amount £1,690,000 (GBP)
Funding ID 104612/Z/14/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2014 
End 10/2019
 
Title Expansion of fMRI capability 
Description 1. A new multi-transmit capability to expand scanning at 7T from the brain only to the whole body. 2. A wide-bore 3T MR scanner for scanning those undertaking exercise studies. 3. A vertical MR scanner for weight-bearing studies of the musculoskeletal system. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2016 
Provided To Others? Yes  
Impact This instrumentation expands the capability for MRI whole body imaging, in the Sir Peter Mansfield Imaging Centre, as it includes a magnet that can accommodate a subject exercising (foot cycle). We can thus assess brain activity at rest and during exercise. 
URL http://www.nottingham.ac.uk/news/pressreleases/2014/october/9m-for-mri-in-nottingham.aspx
 
Title Expansion of metabolomics unit 
Description Mass spectrometers 
Type Of Material Technology assay or reagent 
Year Produced 2015 
Provided To Others? Yes  
Impact With funding from MRC we have acquired several MS instruments as part of the National Phenome Centre. This has allowed us to expand the existing metabolomics capacity and extend the range of metabolites that can be assayed, for example now including lipid based metabolites. 
URL http://www.birmingham.ac.uk/research/activity/phenome-centre/index.aspx
 
Title Fourier Transform-Ion Cyclotron Resonance Mass Spectrometer 
Description for ultra-high mass resolution studies 
Type Of Material Improvements to research infrastructure 
Year Produced 2014 
Provided To Others? Yes  
Impact Use in ultra-high mass resolution studies 
 
Title Glen Creston FreezerMill 
Description This is used for Bone, muscle, cartilage pulverisation 
Type Of Material Biological samples 
Provided To Others? No  
Impact This is used for Bone, muscle, cartilage pulverisation 
 
Title Hybrid Quadropole-Orbitrap Liquid Chromatograph mass spectrometer 
Description Human isotope tracer and metabolism studies 
Type Of Material Improvements to research infrastructure 
Year Produced 2013 
Provided To Others? Yes  
Impact The facility can now measure the turnover of a range of muscle components to give a very broad picture of anabolic and catabolic activity and this will complement the expanding metabolomics research at UoB 
 
Title Mass Spectrometer and Auto Sampler 
Description Human isotope tracer and metabolism studies. (Auto Sampler to enable sample throughput to be markedly increased) 
Type Of Material Improvements to research infrastructure 
Year Produced 2013 
Provided To Others? Yes  
Impact Human isotope tracer and metabolism studies. (Auto Sampler to enable sample throughput to be markedly increased) 
 
Title Mouse homage and phenomaster technology (TSE systems) 
Description This is used to determine energy expenditure in living mice during rest and exercise 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Provided To Others? No  
Impact This determines energy expenditure in living mice during rest and exercise 
 
Title Respiratory Gas Exchange Measurement System (GEM Indirect Calorimeter, GEM Nutrition Limited, UK) 
Description Human metabolic assessment: basal metabolic rate/substrate oxidation 
Type Of Material Physiological assessment or outcome measure 
Provided To Others? No  
Impact Human metabolic assessment: basal metabolic rate/substrate oxidation 
 
Title Seahorse XF24 Metabolic Analyser 
Description Cell metabolism measures on a per cell basis 
Type Of Material Improvements to research infrastructure 
Year Produced 2013 
Provided To Others? Yes  
Impact To extend analysis of metabolism changes with ageing from the organism, through tissue and onto the cellular level. Importantly, the Seahorse instrument selected can analyse single cells in a 96 well format giving us the ability to screen for drug based modulators of metabolism in the future. 
 
Title Upgrade to DXA Bone Densitometer 
Description Human body composition assessment 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact Human body composition assessment 
 
Title Vbot 
Description Analysis of motor control in arm 
Type Of Material Improvements to research infrastructure 
Year Produced 2013 
Provided To Others? Yes  
Impact Analysis of motor control in arm 
 
Description 'Put Pep in Your Step' DVD 
Organisation Move it or Lose It
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution We produced and released our own DVD, launched on October 1st 2013 on World Older Adults Day, comprising a staged exercise programme based on the PEPPI programme validated by Prof Bill Evans but also employing factors revealed by our motivational psychology team to enhance self determination to lifestyle change. These include the use of music and using demonstrators of the appropriate age group, we thus used members of the Birmingham 1000 Elders as the actors on the DVD
Collaborator Contribution Industrial Partner
Impact The DVD is available to buy. Importantly local Age Concern groups and the Birmingham Later Life forum have both bought the DVD to use in their befriending schemes to reduce isolation and improve health in older adults. We have also developed a training course for physical activity trainers in the use of our DVD and exercise programme and we deliver this as a 2-day VTCT accredited course 3 times a year beginning in March 2014. We have also run 2 full day workshops for older adults on healthy ageing with 200 attendees in total.
Start Year 2013
 
Description Cell migration Harvard 
Organisation Harvard University
Country United States 
Sector Academic/University 
PI Contribution Our team has provided complex datasets relating to the impact of trauma on health, notably immunity and physical frailty which is unique in its scale and complexity. In the future we will provide further data from samples analysed using the Harvard technology benefitign from their analytical expertise.
Collaborator Contribution Harvard have provided a novel instrument for measuring immune cell migration to several chemokines at one time and using just a pin prick volume of blood. This simplifies our protocol as we dont need to take a large sample by venepuncture and the data we get is much more detailed. We also benefit from their bioinformatic analysis and data modelling skills.
Impact None yet
Start Year 2015
 
Description Collaboration with KCL on cyclists cohort 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution This collaboration is with Prof Stephen Harridge who has a cohort of master cyclists aged over 55 years. Our contribution is to work with him to determine the impact of lifelong physical activity on body systems, with our team looking at immune function. We also provided data from an age matched inactive control cohort.
Collaborator Contribution The KCL team did the analysis of major body systems including muscle and bone and also managed the cohort.
Impact We have so far published 4 papers from this collaboration. It is multidisciplinary involving metabolic physiologists and immunologists.
Start Year 2012
 
Description Collaboration with Thermo Fisher Scientific to develop new metabolomic assays and software for metabolic phenotyping 
Organisation Thermo Fisher Scientific
Country United States 
Sector Private 
PI Contribution 1. Development and validation and UPLC-MS assays for untargeted metabolomics. 2. Sharing of developed assays for distribution by Thermo Fisher Scientific. 3. Development of new metabolite annotation software. 4. Development of optimal approaches for the collection of MS/MS data in metabolic phenotyping.
Collaborator Contribution 1. Significant reduction in purchase costs of instruments (45% discount). 2. Early beta testing of new software and scientific instruments. 3. Priority engineer visits for scientific instruments.
Impact 1. Loan of a UPLC-MS instrument to the University of Birmingham to be applied for training courses and for assay development work. 2. This collaboration is multi-disciplinary and includes bioinformatics, analytical chemistry and clinical research.
Start Year 2013
 
Description EIP-AHA AG A2 Falls Prevention 
Organisation European Commission
Department European Innovation Partnership on Active and Healthy Ageing
Country European Union (EU) 
Sector Public 
PI Contribution This is a Europe wide partnership with several action areas and we have contributed to A2 which focusses on Falls prevention. One of the activities was to collect together information on Falls prevention programmes. We supplied details of the West Midlands regional Falls service and our current Falls prevention activities.
Collaborator Contribution The other partners have also supplied similar data and this has allowed the consortium to publish its findings on good practice across Europe.
Impact The output to date is the online publication on good practice in Falls prevention in the URL provided. The group now has a future action plan to take us forward to 2018.
Start Year 2012
 
Description Gene Expression analysis in sarcopaenia 
Organisation GlaxoSmithKline (GSK)
Department Research and Development GSK
Country United Kingdom 
Sector Private 
PI Contribution The collabroation is to look at gene expression changes with sarcopneia associated with ageing and also COPD. Prof Greenahff supplied the tissue samples for analysis by GSK.
Collaborator Contribution GSK carried out the gene expression arrays and disucssed the data.
Impact Several publications have arisen and others are still being written up.
Start Year 2010
 
Description Hertfordshire Ageing Cohort 
Organisation University of Cambridge
Department MRC Epidemiology Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution We have worked with the Hertfordshire Ageing Cohort to analyse stored serum samples to determine the impact of systemic inflammation and HPA axis changes with age on muscle and bone mass and function and physical frailty
Collaborator Contribution HAS supplied the samples and associated clinical and physiological data and helped with statistical analysis of the data.
Impact The collaboration has produced 4 papers to date with more in the pipeline.
Start Year 2012
 
Description Kennedy Institute for Rheumatology 
Organisation University of Oxford
Department Kennedy Institute of Rheumatology
Country United Kingdom 
Sector Academic/University 
PI Contribution Professor Chris Buckley, a theme lead in this award, has set up a collaboration with the KIR to accelearte the development of new drugs for Rheumatoid Arthritis. As a result he will now be funded 0.5FTE by the Kenendy Foundation and has received £7m in funding from them for this collaboration, £3.7m of which will come to Birmingham.
Collaborator Contribution The Kennedy Foundation have supported this link and the researchers at the KIR will work with Prof Buckley to develop the new research programme across both sites.
Impact £7m funding from the Kennedy Foundation
Start Year 2017
 
Description MS facility 
Organisation Thermo Fisher Scientific
Country United States 
Sector Private 
PI Contribution Thermo Fisher Scientific has a long standing collaboration with Dr Warwick Dunn and the School of Biosciences at the University of Birmingham and through which support to the MRC-ARUK centre is provided. The University of Birmingham is only one of three academic institutions globally to hold a prestigious mass spectrometry-focussed Technology Alliance Partnership (TAP) with Thermo Fisher Scientific, through which applicatin platforms are developed and applied to the analysis of clinical samples. This as led to biomarker identification for example in Trauma and musculoskeetal disease.
Collaborator Contribution This partnership has provided significant financial input through provision of hardware, consumables and software to a price greater than £90,000 and through the sponsorship of a BBSRC CASE PhD studentship. Support to the £8M MRC-funded Phenome Centre Birmingham has also been provided through significant cost reductions for the purchase of 6 liquid chromatography-mass spectrometry platforms (45% reduction to list prices and only available because of the TAP). Finally, support has been provided by the loan (at no cost) of a liquid chromatography-mass spectrometry platform to be applied by the Birmingham Metabolomics Training Centre and on which a MRC-ARUK centre-specific training course has been operated.
Impact This partnership has led to the expansion of our metabolomics facility, with training courses for basic scientists and clinicians as key outputs as well as several publications.
Start Year 2013
 
Description Preventing Frailty workshops 
Organisation Sanofi Pasteur MSD
Country United Kingdom 
Sector Private 
PI Contribution The collaboration was to deliver a series of three workshops on Healthy Ageing and preventing frailty, with a focus on service change and delivery, in three different counties (Staffordshire, Hampshire and Shropshire) to be attended by key people involved in public health services for older adults. Prof Lord delivered a lecture on Keeping frailty at bay; and held discussions with attendees about how to prevent frailty in older adults.
Collaborator Contribution The partner organised the workshops inviting key players and also funding the whole event.
Impact The main output has been further networking with health care providers to use our DVD and also send people on the associated training programme. Prof Lord has also been invited to deliver similar workshops to Mid-Staffs Health board and contributed to the 2014/15 annual report by the Director of Public Health for Staffordshire which focused on the health of older adults.
Start Year 2014
 
Description Reviews of Scientific Evidence and Policies on Nutrition and Physical Activity 
Organisation ICF International, Inc.
Country United States 
Sector Private 
PI Contribution Reviewing and reporting on literature reviews addressing eight topic areas relating to physical activity and nutrition
Collaborator Contribution ICFi led on the bid to EU_DG Sante to secure funds for this project
Impact Reviews and summary documents to submit to DG Sante
Start Year 2016
 
Title ELMS trial 
Description ELectrical and Magnetic Stimulation to mitigate Intensive Care Unit-acquired weakness after trauma (ELMS) trial tested the use of electricity and magnetism to exercise muscles and prevent sarcopaenia in trauma patients. The ELMS trial is a pilot study of 30 patients which will generate data on feasibility and the sample size required for a full trial. 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2015
Development Status Actively seeking support
Clinical Trial? Yes
Impact The trial revealed that the electrical stimulation mode was the most successful and effective. Magnetic stimulation instruments were difficult to use in an ICU setting. ELMS2 has now been designed and is seeking funding. 
URL http://www.isrctn.com/ISRCTN12562519
 
Title Exercise in RA 
Description This trial assessed the ability of an exercise programme to reduce disease score in patients with Rheumatoid Arthritis compared with a biological therapy. The results were very positive and we are now seeking further funding to extend the study. 
Type Therapeutic Intervention - Psychological/Behavioural
Current Stage Of Development Initial development
Year Development Stage Completed 2015
Development Status Actively seeking support
Impact No other impacts 
 
Title STAG: 11BHSD1 inhibition for improved bone density 
Description The 11bHSD1 inhibitor is being tested in a phase 2 placebo controlled RCT to improve bone density if postmenopausal women. Birmingham is one of the recruitment sites, the study is led by Leeds. 
Type Therapeutic Intervention - Drug
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2016
Development Status Under active development/distribution
Clinical Trial? Yes
Impact None yet as still in testing. 
URL http://www.isrctn.com/ISRCTN32813419
 
Description A departmental lecture, University of Leeds 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact This was an invited lecture at the University of Leeds focussed on muscle metabolic dysregulation with ageing.
Year(s) Of Engagement Activity 2016
 
Description Academic seminar, Kennedy Research Institute, University of Oxford 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact A seminar lecture focussed on differentiating the effects of inflammation and inactivity on muscle metabolic dysregulation in ageing.
Year(s) Of Engagement Activity 2016
 
Description Active Ageing 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Study participants or study members
Results and Impact School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham themed talk on Control of Movement
Year(s) Of Engagement Activity 2016
 
Description Ageing Masterclass 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact A masterclass of researchers presenting on ageing and age related disease to undergraduate and postgraduate students across the University of Nottingham
Year(s) Of Engagement Activity 2018
URL https://revl.world/event/interprofessional-masterclass-ageing-population/
 
Description Agewell 2015 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Age Well went ahead as planned on Thursday the 10th September 2015. This was the 6th annual event of its kind since it began in 2010. Once again, this year saw us move to a bigger venue as the event continues to grow in popularity with approximately 200 'delegates' or attendees from the Birmingham 1000 Elders group -1000 Elders.

Age Well has become an annual public engagement event and is designed as a 'thank you' event in recognition of all the assistance the Birmingham 1000 Elders have provided over the course of the year in research studies, but also acts as an opportunity for researchers to communicate back to the Elders their latest research findings on how to age healthily.
Year(s) Of Engagement Activity 2015
URL http://www.birmingham.ac.uk/generic/mrc-aruk/news/2015/AgeWell2015.aspx
 
Description Agewell Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Over 130 people attended this event that was manned by Centre Researchers and Clinicians. This involved presentations and interactive sessions based around healthy ageing that encouraged this group of older adults to consider how they might alter their lifestyles to ensure they would 'age well'.

Participants came away with ideas on how to improve their diets and lifestyles
Year(s) Of Engagement Activity 2014
 
Description Arthritis Week 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Poster Presentation
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Poster presentations and patient engagement for
Arthritis Week (October 2013)
Queen Elizabeth Hospital, Edgbaston


TBC
Year(s) Of Engagement Activity 2013
 
Description Article on Healthy Ageing 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Contribution to article on
'How to live longer - the experts' guide to ageing'
Experts on the ageing process explain why having good friends, lifting weights and learning languages can lead to a longer life


Knowledge Share
Year(s) Of Engagement Activity 2013
URL http://www.theguardian.com/science/2013/sep/08/how-to-live-longer-experts-guide-ageing
 
Description Attendance Integrative Physiology of Exercise Meeting in USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster presentation on gene expression changes from this project
Year(s) Of Engagement Activity 2018
 
Description BBC Midlands Today News 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact BBC Midlands Today News local news report about robot-assisted training research for stroke survivors
Year(s) Of Engagement Activity 2016
 
Description BBC Science How to Stay Young 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact This was a 2 part programme for BBC Science called "How to Stay Young". In one whole episode the MRC-ARUK Centre demonstrated a simple test for physical functioning and healthy ageing, this was then tried by the commentator Angela Rippon. The filming also involved the general public and older adults. 6 of the older adults gaining low scores then worked with our SME partner Move it or Lose It doing an exercise routine and then 8 weeks later they were re-tested and all but one improved. It will broadcast april 2016.
Year(s) Of Engagement Activity 2016
 
Description BBC TV broadcast 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact BBC TV visited the David Greenfield Human Physiology Unit at the University of Nottingham to film this BBSRC funded bed-rest study.
Year(s) Of Engagement Activity 2018
 
Description BBC news item and press media coverage on master cyclists 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact This was a news item on the BBC and over 30 associated press articles internationally reporting our recent publications showing that lifelong physical activity not only prevented musculoskeletal decline but also protected the immune system.
Year(s) Of Engagement Activity 2018
 
Description British Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact We had four events running at the British Science Festival all designed to stimulate conversation and encourage healthy and active living. These were all developed and organised by Centre affiliated Researchers, students and clinicians.
The events were as follows:
1. 'How Old are You Really' - A talk on the importance of healthy living and chance for the audience to participate in various interactive sessions to determine how well they were physically ageing .
2. An interactive panel session and live demonstrations based around the premise 'Not enough exercise, too much stress: The curse of modern living'.
3. A hands-on exhibition for the young peoples programme on "Osteoarthritis and Risk Factors"
4. Two interactive lectures on Metabolism, muscle, exercise and ageing also for the young peoples programme.

Feedback from the events showed people suggesting they would improve their diet and exercise regimes as a result of the information they had discovered.
Year(s) Of Engagement Activity 2014
 
Description Can we reduce sitting time to improve physical function in older adults undergoing hip or knee replacement surgery: Innov-age magazine article 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Not aware of any impact
Year(s) Of Engagement Activity 2019
 
Description Christmas Lectures 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Dr Rick Dunn, the systems biology theme lead, provided two Christmas science lectures to year 7 children to engage with them about the importance of food and its impact on the human body in relation to health and ageing.

This event translated an important area of science into something that young people could understand and encouraged them, through a fun and interesting interactive session, to contemplate the importance of diet in terms of ageing.
Year(s) Of Engagement Activity 2013
 
Description Contribution to Guardian article 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact This article ' Ageing revolution must benefit us all' led to requests for Professor Janet Lord to speak at various public events and further enquiries into her Research.

Not recorded
Year(s) Of Engagement Activity 2014
URL http://www.theguardian.com/science/2014/jul/09/ageing-revolution-must-benefit-all
 
Description Creation and publication of website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Created website to promote our research objectives, our research outputs and impacts. Also to publicise our current clinical research studies to patients and their clinicians.
Year(s) Of Engagement Activity 2018
URL http://www.oamig.com
 
Description Documentary on Healthy Ageing 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The Centre researchers at UoB were filmed over 3 days by Japanese national TV for a documentary on healthy ageing to be screened in April 2014 in Japan but then across Europe in summer 2014.

Public Awareness
Year(s) Of Engagement Activity 2014
 
Description Exercise and vitamin D supplementation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact Invited speaker at a local National Osteoporosis Society meeting
Year(s) Of Engagement Activity 2017
 
Description Exercise for Sarcopenia: What's the Evidence? Presentation to the British Geriatrics Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Not aware of any impact
Year(s) Of Engagement Activity 2019
 
Description Falls prevention project with Birmingham libraries 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact This activity was done with Move it ro Lose It. 100 books and 100 "Put Pep in your Step" DVDs developed with our Centre input were placed in 4 libraries across Birmingham.
Those who borrow the book/DVD are given a voucher for a free Move it or Lose it class. 2 x 12 week programmes are running at Northfield Library and West Heath Medical Centre to test falls risk using a QTUG and then follow strength and balance classes to reduce frailty. We will evaluate progress and signpost to other community classes.This is funded by RoSPA and Birmingham South Central CCG
Year(s) Of Engagement Activity 2017
 
Description Healthy Ageing Policy Commission Report 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Participants in your research and patient groups
Results and Impact Professor Janet Lord and Centre PI Janice Thompson both played key roles in the ongoing investigations that fed into the Healthy Ageing Policy Commission Report. Preparation for the report involved extensive research with older people living within local super-diverse communities in order to find out what their requirements were and how they felt progress could be made towards healthy ageing.


The work that went into this research resulted in the creation of the policy commission report ' Healthy Ageing in the 21st Century: The Best is Yet To Come' which was launched initially in the House of Commons and then at Birmingham CIty Council.
Year(s) Of Engagement Activity 2011,2012,2013,2014
URL http://www.birmingham.ac.uk/research/impact/policy-commissions/healthy-ageing/report.aspx
 
Description How to Stay Young 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact This was a programme made by BBC Science, in 3 parts in season 1 (2016) and 2 parts in season 2 (2017). The Centre's researchers and our PPI group featured in both and showed how to assess how well you are ageing and the benefits of physical activity.
Year(s) Of Engagement Activity 2016,2017
 
Description I attended the expert "think-tank" workshop titled "Influencing the trajectories of ageing"at the Academy of Medical Sciences, London 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This was an expert workshop aimed at exploring the current developments in ageing research and how this science can be used for decision-making by better predicting longevity and health.
Year(s) Of Engagement Activity 2016
URL https://acmedsci.ac.uk/file-download/41227-5746fb4d0f825.pdf
 
Description I delivered a lecture titled "Is there a role of insulin resistance in driving muscle disuse atrophy?" in the symposium "The control of skeletal muscle atrophy in responses to disuse: clinical/ pre-clinical contentions and fallacies of evidence" at Experimental Biology, San Diego (2-6th April 2016) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Loss of skeletal muscle mass in response to mechanical unloading is associated with prolonged bed-rest, casting of lower-limbs due to broken/fractured bones, and spaceflight. Moreover, a number of catabolic conditions including age-related sarcopenia and numerous diseases associated with muscle wasting i.e. respiratory or organ failure; are exacerbated by interactions between disease(s) pathogenesis (i.e. inflammation) and increasingly sedentary behaviours associated with ill-health. Indeed, the physiological and metabolic consequences of skeletal muscle unloading are profound including: skeletal muscle atrophy, bone loss, whole-body/muscle insulin resistance, fluid shifts and cardio-respiratory de-conditioning. This symposium focussed on the physiological/metabolic disturbances associated with disuse atrophy with contributors conveying knowledge yielded from clinical and pre-clinical studies (and from multi-modal approaches).
Year(s) Of Engagement Activity 2016
 
Description Innov-Age Articles 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Two of the Centre's researchers including PI Carolyn Greig contributed articles to the Innov-Age magazine's Musculoskeletal Issue. These articles were, respectively ' Depression after hip-fracture among older adults' and 'Can vitamin D supplementation enhance the effects of health training in frail older adults'. The magazine currently has 1500 + and growing subscribers, who are a mix of HCPs & clinicians, academics, care home and medtech industry.

These articles were expected to inform the group mentioned above on these key issues.
Year(s) Of Engagement Activity 2014
URL http://issuu.com/yuanzhenuk/docs/innov-age_issue_5_spring_2014-2015/13?e=8238530/7759661
 
Description Interactive presentation and poster 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Poster Presentation
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Marshall, J., Long, J., Zhang, Y, Lord, J., Tomlinson, J., Phillips, A.C., Toellner, K. Topjabs: Can we improve vaccination responses in elders? Interactive presentation and poster at Lifelong Health and Wellbeing Public Showcase, University of Edinburgh, December, 2012

Knowledge Share
Year(s) Of Engagement Activity 2012
 
Description Invited Speaker to West Midlands Healthy Ageing Forum: 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Dr Carolyn Greig's talk 'Healthy Ageing: Can We Turn Back The Clock?' stimulated discussion amongst the audience.

None yet reported
Year(s) Of Engagement Activity 2014
 
Description Invited Talk and Display 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Lord, J.M. and Phillips, A.C. Synergistic effects of hip fracture and depression in ageing. Invited talk and display for NDA and LLHW joint Public Engagement Event, Birmingham, May 2013.

Knowledge Share
Year(s) Of Engagement Activity 2013
 
Description Keynote lecture, American College of Sports Medicine Annual Meeting 2018, Minneapolis, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Keynote lecture, American College of Sports Medicine Annual Meeting 2018, Minneapolis, USA
Year(s) Of Engagement Activity 2018
 
Description Magazine Article - Yours 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact This was a full feature in the magazine Yours on exercises to reduce pain in arthritis in 2013 which was followed up in 2015, given by our colleague Julie Robinson.

Public Awareness
Year(s) Of Engagement Activity 2013,2015
URL http://www.yours.co.uk/2015/07/ask-our-feel-younger-expert-could-exercise-help-my-arthritis
 
Description Neuromuscular Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation workshop facilitator
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This workshop was led by one of the Centre theme leads and contributions were made from other Centre related staff and students. The event involved lab demonstrations related to neuromuscular ageing to stimulate discussion on various techniques and talks from internal and external speakers designed to create discussion on new and developing research.

This helped introduce various researchers within this field to new and developing topics and the possibility of new collaborations.
Year(s) Of Engagement Activity 2014
 
Description Newspaper Article - Sunday Telegraph 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Article on Stress and Ageing in the Sunday Telegraph

Public awareness
Year(s) Of Engagement Activity 2013
 
Description Nottingham Living Well Ageing Well 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact This was an evening event at Nottingham County Hall consisting of 4 short talks on the subject of Healthy Ageing attended by 200 people. There were 2 speakers from each of the MRC-ARUK Musculoskeletal Ageing Research Centres covering why we age and how lifestyle can prevent many of the aspects of physical frailty. The event was videoed and is available online.
Year(s) Of Engagement Activity 2015
URL http://www.birmingham.ac.uk/generic/mrc-aruk/news/2015/Living-Well-Ageing-Well.aspx
 
Description Obesity Wars - Public Interaction 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Various Centre PI's, Co-I's and students manned interactive stations showing the importance of eating healthily and exercising. This was held at the Think Tank in Birmingham and over 1700 people passed through the venue during the day. Participants were encouraged to think about the calories different types of food contained, see what differences exercising could make and see how well they were ageing in relation to their general health and activity levels. This was funded by the Physiological Society.

The event lead, Prof Janice Thompson also took part in a podcast for the University of Birmingham Ideas Lab on this topic.


The School of Sportexr video'd various people at the event describing what they had learnt and suggesting changes in their lifestyles and exercising regimes they would make as a result of this knowledge.
Year(s) Of Engagement Activity 2014
URL http://www.birmingham.ac.uk/news/podcasts/index.aspx
 
Description PAHA Feedback Event 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Centre affiliated researchers from the University and the hospital organised and took part in a feedback event for over one hundred participants from a recent study on 'Physical Activity and Healthy Ageing'. The event included talks from the researchers involved in the study discussing aspects of the results including cardiovascular function, immune function and more general measures like body composition in relation to physical activity.

Research participants spoke of their change in exercise and eating habits as a result of the tests themselves and then further from the test results.
Year(s) Of Engagement Activity 2014
 
Description Physiological Society annual meeting (symposium) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact I presented a talk entitled "Physical inactivity and age-related declines in muscle metabolic health" in the symposium "Physiological approaches to study the science of human sedentariness" at Physiology 2016, which was a Joint Meeting of the American Physiological Society and The Physiological Society, 29 - 31 July 2016, Convention Centre Dublin, Ireland.
Non-communicable chronic diseases, such as cardiovascular disease, cancer and type 2 Diabetes account worldwide for ~48% of healthy life years lost (Disability Adjusted Life Years DALYs; ~65% of all current deaths, and are projected to cause over 75% of all deaths by 2030. A substantial body of epidemiological and experimental evidence has established a causal relationship between NCDs and preventable risk factors, with physical inactivity being at the heart of these. Moreover, there is accumulating epidemiological evidence to suggest that sitting time is an independent risk factor, perhaps being even independent of the amount of leisure-time physical activity and body adiposity. The study of sedentariness is an emergent science, meaning we know relatively little about the physiological drivers and mechanisms mediating the metabolic and dysregulation associated with sedentariness or the time-course of their effects with few mechanistic studies to date reliant upon measures that are definitive in terms of muscle protein turnover and insulin resistance. This disconnect will ultimately limit the effectiveness of strategies to combat this burgeoning public health problem.
The purpose of this symposium was to present current information on the metabolic physiology of sedentariness. The senior speakers will provided an overview of current insights gained from human mechanistic studies of acute immobilisation/ inactivity as well as applied studies of the acute effects of sitting time and their influence on cardio-metabolic risk, whilst early career researchers presented their current cutting-edge research utilising both basic and applied science approaches. The seminar was attended by established and early career researchers and news press and has added to the current increase in the sedentariness on human health and sparked further research focussed meetings on ageing and health.
Year(s) Of Engagement Activity 2016
URL http://www.physiology2016.org/scientific-programme/physiological-approaches-study-science-human-sede...
 
Description Podcast 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact University of Birmingham Ideas Lab. What it means to befit. Podcast. 24 July 2013.

Public Awareness
Year(s) Of Engagement Activity 2013
URL http://audioboo.fm/boos/1538795-what-it-means-to-be-fit-ideas-lab-podcast#t=1m38s
 
Description Presentation SW Jones 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach National
Primary Audience Supporters
Results and Impact S W Jones. Presentation to Boots Healthcare International to seek funding "Identifying new personalised medicines for patients with osteoarthritis" Held at the University Birmingham Campus.

TBC
Year(s) Of Engagement Activity 2013
 
Description Presentation to the Birmingham 1,000 Elders group 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Study participants or study members
Results and Impact A presentation on the negative impact of obesity and inactivity of metabolic health and ageing processes.
Year(s) Of Engagement Activity 2017
 
Description Princes Teaching Institute 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact This activity relates to 5 talks given at a series of workshops for secondary school science teachers organised by the Princes Teaching Institute. We have given the talks, covering Human musculoskeletal ageing, Immune ageing and The Response to Trauma to workshops around the UK. As a result we have been invited to give these talks to school pupils in the schools the teachers belong to. The original session and the ones in schools have triggered lively discussion of the topics and been very enjoyable as well as raising awareness of the two topic areas.
Year(s) Of Engagement Activity 2014,2015,2016,2018,2020
 
Description Prof Janet Lord - Article in Yours magazine 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact This article 'Simple steps to healthy ageing' by Prof Janet Lord was designed to encourage the general public to consider the importance of healthy ageing, giving them tips on diet, exercise, supplements and general wellbeing to help them develop healthier lifestyles.

None recorded
Year(s) Of Engagement Activity 2014
URL http://www.yours.co.uk/2014/07/simple-steps-to-healthy-ageing-beat-inflammation-and-reduce-your-risk...
 
Description TV Interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact BBC Midlands Today (18.30 newscast). Interviewed for top feature story on Birmingham City Council cutting the local budget for leisure and sport by £3.5 million and potential implications for public health and the Olympic legacy. 5 June 2013.

Public Awareness
Year(s) Of Engagement Activity 2013
 
Description Television Involvement 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact BBC2, Trust Me I'm a Doctor. "Can You Be Fit and Fat?" Episode 1, 10 October 2013, 20:00.


Public Awareness
Year(s) Of Engagement Activity 2013
URL http://www.bbc.co.uk/iplayer/episode/p01dgf1w/Trust_Me_Im_A_Doctor_Episode_1/
 
Description The BMI Lie 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Prof Janice Thompson was both a presenter and panel member for this event at the Cheltenham Science Festival. The session focused on the real risks of being unhealthy and whether we rely purely on our body mass index - The event stimulated discussion and invited questions from the audience.

Those present were encouraged to consider how healthy their diets really were and how they could improve upon them.
Year(s) Of Engagement Activity 2014
 
Description Trust Me I'm a Doctor 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Centre Researchers collected VO2max and body composition data on 11 adults to illustrate the limits of using body mass index as an indicator of health, and to promote the health benefits of fitness over body weight - This was designed to encourage the general public to question their fitness and general health levels.

The series attracted 3.2 million viewers, with approximately 200,000 additional views documented via BBC iPlayer
Year(s) Of Engagement Activity 2014
 
Description U3A talks 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact This is one of my regular talks to local older peoples groups, they are well attended and I do 3 or 4 a year. This is to tell them about our work and the immune and musculoskeletal systems are major focus.
Year(s) Of Engagement Activity 2017
 
Description University of Birmingham Arts and Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact The event was entitled 'stop sitting, start moving'. It included talks about research on ageing and sedentariness followed by an exercise (seated yoga) class. The event was in collaboration with the University of Birmingham Sport and Fitness Centre.
Year(s) Of Engagement Activity 2018
 
Description Wellcome Trust PE Leadership Course 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Professor Janet Lord took part in 2 of these workshops in order to help determine exercise reccommendations for Elders.

The result of this activity was a brochure for Arthritis Research UK to be distributed
Year(s) Of Engagement Activity 2014
 
Description £9m for MRI in Nottingham to revolutionise research into disease 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact This press release was issued to tell the general public about a major Government investment into University of Nottingham facilities - securing Nottingham's position in the vanguard of MRI research internationally for the next 10 years.

This is expected to generate more interest and potential funding opportunities in this area of Research at the UoN.
Year(s) Of Engagement Activity 2014
URL http://www.nottingham.ac.uk/news/pressreleases/2014/october/9m-for-mri-in-nottingham.aspx