Epidemiological and statistical research on health problems of developing countries: MRC Tropical Epidemiology Group
Lead Research Organisation:
London Sch of Hygiene and Trop Medicine
Department Name: Epidemiology and Population Health
Abstract
The past decade has seen significant progress in health in developing countries as well as setbacks and new challenges. Gains in health in many low-income countries have been reversed due to the global epidemic of HIV/AIDS and steep increases in tuberculosis (TB). Malaria remains a major killer of children in Africa despite declines in some countries. There is an urgent need to find effective means of controlling these major diseases.
The main aim of the MRC Tropical Epidemiology Group, based at the London School of Hygiene & Tropical Medicine, is to conduct research on interventions against diseases of major public health importance in Africa and other parts of the developing world. We collaborate with scientific groups overseas, including MRC Units in The Gambia and Uganda, assisting with the planning and analysis of research studies. These studies are designed to improve our understanding of risk factors for these diseases, and to evaluate the impact of different control measures. During the next five years, our main focus will continue to be on HIV, TB and malaria, and we will expand our work on non-communicable diseases, which are rapidly increasing in importance in developing countries.
There have been major advances in HIV prevention in recent years, especially around the potential for antiretroviral drugs to be used to prevent HIV transmission. We will work on further studies to evaluate methods of preventing and treating HIV infection, and to scale up interventions, such as voluntary medical male circumcision, that are known to reduce the risk of HIV infection. We will also expand work on integration of care for HIV-patients with treatment of other chronic diseases such as heart disease and diabetes. Research on human papillomavirus (HPV), which can cause cervical cancer, will include studies of how best to deliver HPV vaccination to girls and young women in sub-Saharan Africa.
Our TB research will focus on large-scale trials to assess how best to treat patients co-infected with both TB and HIV, and to improve the ways in which care for TB and HIV are integrated. A new diagnostic test for TB which has the potential to revolutionize TB diagnosis has recently been developed (Xpert MTB/RIF). We will also evaluate the impact and cost-effectiveness of this test for routine TB diagnosis in South Africa.
Substantial reductions in malaria have been reported recently, but much of this progress has been in countries with low levels of malaria, and malaria rates remain unacceptably high in many African countries. In the Sahel region, most of the malaria mortality and morbidity occurs during the short rainy season. We have been closely involved in research showing that giving effective malaria chemoprevention during this period prevents illness and death from malaria in children. We will continue our research in this area, including assessing the impact of this treatment strategy on malaria cases and deaths when delivered through routine health services. We will also continue research on promising malaria vaccines, and to evaluate new methods to control the mosquitoes that transmit malaria.
While the major infectious diseases continue to play a major role, especially in sub-Saharan Africa, there is increasing recognition of the impact of non-communicable diseases. The prevalence of conditions such as cardiovascular disease, diabetes and mental illness is increasing, especially in growing urban centres in developing countries, and will require innovative approaches to prevention and control.
There are few experienced medical statisticians in research institutions and universities in Africa, and an important aspect of our work is to support a fellowship scheme, which provides a two-year training programme for statisticians. In addition, we teach research methods at workshops at collaborating sites and provide informal mentoring and supervision to statisticians and epidemiologists we work with.
The main aim of the MRC Tropical Epidemiology Group, based at the London School of Hygiene & Tropical Medicine, is to conduct research on interventions against diseases of major public health importance in Africa and other parts of the developing world. We collaborate with scientific groups overseas, including MRC Units in The Gambia and Uganda, assisting with the planning and analysis of research studies. These studies are designed to improve our understanding of risk factors for these diseases, and to evaluate the impact of different control measures. During the next five years, our main focus will continue to be on HIV, TB and malaria, and we will expand our work on non-communicable diseases, which are rapidly increasing in importance in developing countries.
There have been major advances in HIV prevention in recent years, especially around the potential for antiretroviral drugs to be used to prevent HIV transmission. We will work on further studies to evaluate methods of preventing and treating HIV infection, and to scale up interventions, such as voluntary medical male circumcision, that are known to reduce the risk of HIV infection. We will also expand work on integration of care for HIV-patients with treatment of other chronic diseases such as heart disease and diabetes. Research on human papillomavirus (HPV), which can cause cervical cancer, will include studies of how best to deliver HPV vaccination to girls and young women in sub-Saharan Africa.
Our TB research will focus on large-scale trials to assess how best to treat patients co-infected with both TB and HIV, and to improve the ways in which care for TB and HIV are integrated. A new diagnostic test for TB which has the potential to revolutionize TB diagnosis has recently been developed (Xpert MTB/RIF). We will also evaluate the impact and cost-effectiveness of this test for routine TB diagnosis in South Africa.
Substantial reductions in malaria have been reported recently, but much of this progress has been in countries with low levels of malaria, and malaria rates remain unacceptably high in many African countries. In the Sahel region, most of the malaria mortality and morbidity occurs during the short rainy season. We have been closely involved in research showing that giving effective malaria chemoprevention during this period prevents illness and death from malaria in children. We will continue our research in this area, including assessing the impact of this treatment strategy on malaria cases and deaths when delivered through routine health services. We will also continue research on promising malaria vaccines, and to evaluate new methods to control the mosquitoes that transmit malaria.
While the major infectious diseases continue to play a major role, especially in sub-Saharan Africa, there is increasing recognition of the impact of non-communicable diseases. The prevalence of conditions such as cardiovascular disease, diabetes and mental illness is increasing, especially in growing urban centres in developing countries, and will require innovative approaches to prevention and control.
There are few experienced medical statisticians in research institutions and universities in Africa, and an important aspect of our work is to support a fellowship scheme, which provides a two-year training programme for statisticians. In addition, we teach research methods at workshops at collaborating sites and provide informal mentoring and supervision to statisticians and epidemiologists we work with.
Technical Summary
We will conduct epidemiological research on HIV, TB, malaria and other diseases of public health importance in developing countries with an emphasis on randomised intervention trials.
In HIV, we will conduct the first trial of the impact of a test-and-treat intervention on HIV incidence in Africa, implementation research on scale-up of male circumcision, and RCTs to reduce early mortality among patients with low CD4 counts and to evaluate different treatment strategies for cryptococcal meningitis.
In TB, we will complete a trial of a four-month pulmonary TB treatment regimen. We will extend our research on treatment strategies for TB and HIV co-infection, including trials to compare 3 treatment strategies in ARV-naïve TB/HIV patients, a CRT to assess the effect of a point-of-care TB test-and-treat algorithm on early mortality in HIV-infected patients accessing ART; and a CRT of the impact of TB diagnosis by Xpert MTB/RIF on mortality and time-to-initiation of treatment.
Malaria research will build on previous work on Seasonal Malaria Chemoprevention (SMC), to evaluate effectiveness of delivery through routine health services, to monitor for adverse effects and to determine the effectiveness of adding SMC to existing control strategies for malaria. We will continue to evaluate multi-component malaria control on Bioko Island, and will develop new collaborations to assess the role of the RTS,S vaccine if licensed.
We will continue trials on lay-health worker interventions to treat common mental disorders, on the beneficial and adverse effects of helminths and antihelmintics on other conditions and of the effectiveness of pneumococcal vaccines. Methodological work will include spatial analysis of spill-over effects in CRTs, and evaluation and prediction of vaccine impact. Finally, we will continue to build research capacity in Africa, including development of the MRC-supported Mwanza Intervention Trials Unit and our programme of TEG training fellowships.
In HIV, we will conduct the first trial of the impact of a test-and-treat intervention on HIV incidence in Africa, implementation research on scale-up of male circumcision, and RCTs to reduce early mortality among patients with low CD4 counts and to evaluate different treatment strategies for cryptococcal meningitis.
In TB, we will complete a trial of a four-month pulmonary TB treatment regimen. We will extend our research on treatment strategies for TB and HIV co-infection, including trials to compare 3 treatment strategies in ARV-naïve TB/HIV patients, a CRT to assess the effect of a point-of-care TB test-and-treat algorithm on early mortality in HIV-infected patients accessing ART; and a CRT of the impact of TB diagnosis by Xpert MTB/RIF on mortality and time-to-initiation of treatment.
Malaria research will build on previous work on Seasonal Malaria Chemoprevention (SMC), to evaluate effectiveness of delivery through routine health services, to monitor for adverse effects and to determine the effectiveness of adding SMC to existing control strategies for malaria. We will continue to evaluate multi-component malaria control on Bioko Island, and will develop new collaborations to assess the role of the RTS,S vaccine if licensed.
We will continue trials on lay-health worker interventions to treat common mental disorders, on the beneficial and adverse effects of helminths and antihelmintics on other conditions and of the effectiveness of pneumococcal vaccines. Methodological work will include spatial analysis of spill-over effects in CRTs, and evaluation and prediction of vaccine impact. Finally, we will continue to build research capacity in Africa, including development of the MRC-supported Mwanza Intervention Trials Unit and our programme of TEG training fellowships.
Planned Impact
As highlighted in the Millennium Development Goals, there is a strong synergy between ill-health and poverty. Our research focuses on diseases that are major causes of morbidity and mortality in resource-poor countries. These diseases have a substantial impact on the socio-economic development of many of these countries. By reducing the rates of important causes of ill health, such measures have the potential to alleviate poverty as well as improving life expectancy. We are expanding our focus on implementation research of proven interventions, and health systems research, which can improve the effectiveness and efficiency of health care delivery and ensure that resources reach the right people.
Many of the diseases we focus on typically affect the poorest in resource-poor countries, and those marginalised from society. We have a strong focus on community-based interventions (for example, in the PopART and TB trials which incorporate home-based HIV and TB testing) which help to overcome barriers to health service access and minimize stigma and discrimination. We also focus on scaling-up interventions which have been proven to be effective - for example male circumcision for HIV prevention, and seasonal malaria chemoprevention in areas with highly seasonal malaria transmission. This implementation research will help ensure access to effective prevention technologies for those who need it, regardless of socio-economic status. Our expanding health systems research (for example on integrating HIV and non-communicable disease treatment and care) will also increase the population-level impact of known effective treatment.
Our research is locally disseminated to study populations, and to regional and national stakeholders and policymakers, as appropriate. This includes providing information to enable policy-makers to make decisions about cost-effective strategies of roll-out (for example, for HPV vaccination or male circumcision scale-up), or access to new technology (such as TB diagnostics including Xpert MTB/RIF). We also play an active role in influencing global health policy and directions for future research, through membership of international technical and policy advisory committees including chairing the WHO Joint Technical Expert Group on Malaria Vaccines in Pivotal Phase 3 Trials & Beyond, the WHO Malaria Policy Advisory Committee Evidence Review Group on Malaria Burden Estimation and the EDCTP Partnership Board; and membership of several other Committees, as outlined in the Case for Support.
Many of the diseases we focus on typically affect the poorest in resource-poor countries, and those marginalised from society. We have a strong focus on community-based interventions (for example, in the PopART and TB trials which incorporate home-based HIV and TB testing) which help to overcome barriers to health service access and minimize stigma and discrimination. We also focus on scaling-up interventions which have been proven to be effective - for example male circumcision for HIV prevention, and seasonal malaria chemoprevention in areas with highly seasonal malaria transmission. This implementation research will help ensure access to effective prevention technologies for those who need it, regardless of socio-economic status. Our expanding health systems research (for example on integrating HIV and non-communicable disease treatment and care) will also increase the population-level impact of known effective treatment.
Our research is locally disseminated to study populations, and to regional and national stakeholders and policymakers, as appropriate. This includes providing information to enable policy-makers to make decisions about cost-effective strategies of roll-out (for example, for HPV vaccination or male circumcision scale-up), or access to new technology (such as TB diagnostics including Xpert MTB/RIF). We also play an active role in influencing global health policy and directions for future research, through membership of international technical and policy advisory committees including chairing the WHO Joint Technical Expert Group on Malaria Vaccines in Pivotal Phase 3 Trials & Beyond, the WHO Malaria Policy Advisory Committee Evidence Review Group on Malaria Burden Estimation and the EDCTP Partnership Board; and membership of several other Committees, as outlined in the Case for Support.
Organisations
- London Sch of Hygiene and Trop Medicine, United Kingdom (Lead Research Organisation)
- Georgia Institute of Technology, United States (Collaboration)
- University of Edinburgh, United Kingdom (Collaboration)
- Foundation for Professional Development (Collaboration)
- University of Namibia (Collaboration)
- University of Khartoum (Collaboration)
- University of Yaoundé (Collaboration)
- Merlin, Afghanistan (Collaboration)
- National Hospital of Pneumo-Phtisiology (Collaboration)
- University of Nigeria (Collaboration)
- Innovations for Poverty Action (IPA) (Collaboration)
- BOL NIGERIA ! Bclems Outsourcing Limited (Collaboration)
- University of Heidelberg, Germany (Collaboration)
- University of Oxford, United Kingdom (Collaboration)
- National Institute for Medical Research (Collaboration)
- Clinton Health Access Initiative (Collaboration)
- HealthNet (Collaboration)
- University Hospitals in Paris (Collaboration)
- World Health Organization (WHO) (Collaboration)
- Center of Medical Research Lambaréné (Collaboration)
- University of Texas at San Antonio, United States (Collaboration)
- University of Birmingham, United Kingdom (Collaboration)
- Ignace Deen Hospital (Collaboration)
- IRD Global (Collaboration)
- Family Health International (Collaboration)
- National Institutes of Health, United States (Collaboration)
- WellcomeTrust Africa Centre (Collaboration)
- The Pirbright Institute, WOKING (Collaboration)
- Médecins Sans Frontières (MSF) (Collaboration)
- Mbarara National Referral Hospital (Collaboration)
- Makerere University, Uganda (Collaboration)
- Chinese Center for Disease Control and Prevention (China CDC) (Collaboration)
- Ministry of Health, Uganda (Collaboration)
- Sao Paulo State University (Collaboration)
- University College London, United Kingdom (Collaboration)
- Government of China (Collaboration)
- University of Tromsoe, Norway (Collaboration)
- Institute of Tropical Medicine (Collaboration)
- Fred Hollows Foundation (Collaboration)
- National Health Laboratory Services, South Africa (Collaboration)
- University of Gondar (Collaboration)
- Leishmaniasis East Africa Platform (LEAP) (Collaboration)
- Weill Cornell Medical College in Qatar (Collaboration)
- Christian Medical College Vellore (Collaboration)
- National Vector-borne Diseases Control Programme (NVDCP) (Collaboration)
- Public Health Foundation of India (Collaboration)
- University of Ottawa, Canada (Collaboration)
- Queen Margaret University Edinburgh, United Kingdom (Collaboration)
- Royal Netherlands Chemical Society (Collaboration)
- Makerere University College of Health Sciences (Collaboration)
- Brown University, United States (Collaboration)
- Bayer (Collaboration)
- Zimbabwe Population Services International (PSI) (Collaboration)
- Vanderbilt University, United States (Collaboration)
- Pennsylvania State University, United States (Collaboration)
- Norwegian University of Life Sciences (NMBU) (Collaboration)
- University of California, San Francisco, United States (Collaboration)
- Drugs for Neglected Diseases initiative (DNDi) (Collaboration)
- Imperial College London, United Kingdom (Collaboration)
- The Wellcome Trust Sanger Institute (Collaboration)
- University of Bamako (Collaboration)
- Worldwide Antimalarial Resistance Network (Collaboration)
- Nagasaki University (Collaboration)
- Institute of Development Research (IRD) (Collaboration)
- Catalan Institute of Oncology (Collaboration)
- University of the Witwatersrand, South Africa (Collaboration)
- Johns Hopkins University, United States (Collaboration)
- Ministry of Health and Social Welfare (Collaboration)
- Programme National de Lutte contre la Tuberculose (Collaboration)
- Medical Care Development International (MCDI) (Collaboration)
- Zanzibar Malaria Control Program (Collaboration)
- Aberystwyth University, United Kingdom (Collaboration)
- University of Cape Town (Collaboration)
- National Center for Scientific and Technological Research (CNRST) (Collaboration)
- Zambia AIDS Related Tuberculosis (Collaboration)
- Armauer Hansen Research Institute (Collaboration)
- HST (Collaboration)
- Harvard University (Collaboration)
- University of Liverpool, United Kingdom (Collaboration)
- Mott Macdonald UK Ltd, United Kingdom (Collaboration)
- University of Malawi, Malawi (Collaboration)
- Sagarmatha Choudhary Eye Hospital (Collaboration)
- Kintampo Health Research Centre (Collaboration)
- European Commission, Belgium (Collaboration)
- Medical Research Council of South Africa (MRC) (Collaboration)
- Africa Health Research Institute (Collaboration)
- Ifakara Health Institute, Tanzania, United Republic of (Collaboration)
- Ghana Health Service (Collaboration)
- Centers for Disease Control and Prevention (CDC) (Collaboration)
- Entebbe District Hospital (Collaboration)
- United States President's Emergency Plan for AIDS Relief (Collaboration)
- Entomological Research Centre of Cotonou (CREC) (Collaboration)
- National Malaria Control Programme, Cambodia (Collaboration)
- Health Protection and Research Organisation (HPRO) (Collaboration)
- Yale University (Collaboration)
- Aix-Marseille University, France (Collaboration)
- In2Care BV (Collaboration)
- Umea University, Sweden (Collaboration)
- University of Copenhagen, Denmark (Collaboration)
- Kilimanjaro Christian Medical Centre (KCMS) (Collaboration)
- Khon Kaen University (Collaboration)
- University of Sussex, United Kingdom (Collaboration)
- Wellcome Trust, LONDON (Collaboration)
- Wits Health Consortium (Collaboration)
- Navrongo Health Research Centre (NHRC) (Collaboration)
- Aurum Institute (Collaboration)
- University Cheikh Anta Diop de Dakar (Collaboration)
- Avenir Health (Collaboration)
- The Statens Serum Institute (SSI) (Collaboration)
- University of KwaZulu-Natal (Collaboration)
- University of Delhi (Collaboration)
- African Population and Health Research Center (Collaboration)
- Itad Ltd (Collaboration)
- Elimination Eight (Collaboration)
- Oswaldo Cruz Foundation (Fiocruz) (Collaboration)
- Addis Ababa University, Ethiopia (Collaboration)
- Queen Mary, University of London, United Kingdom (Collaboration)
- Centre for Sexual Health and HIV AIDS Research Zimbabwe (CeSHHAR Zimbabwe) (Collaboration)
- University of Sheffield, United Kingdom (Collaboration)
- Cote D'Ivoire's National Institute of Public Health (Collaboration)
- MRC/UVRI Uganda Research Unit on AIDS, Uganda (Collaboration)
- Xinjiang Medical University (Collaboration)
- Epicentre (Collaboration)
- Western University (Collaboration)
- Roll Back Malaria (Collaboration)
- Monash University, Australia (Collaboration)
- Muhimbili Wellcome Programme (Collaboration)
- Karolinska Institute, Sweden (Collaboration)
- St George's University of London, United Kingdom (Collaboration)
- Bill and Melinda Gates Foundation (Collaboration)
- Sangath (Collaboration)
- Stellenbosch University, South Africa (Collaboration)
- International Union Against Tuberculosis and Lung Disease (The Union) (Collaboration)
- University of York, United Kingdom (Collaboration)
- Medical Research Council (Collaboration)
- Viiv Healthcare (Collaboration)
- National Malaria Control Programme, Tanzania (Collaboration)
- University of Zambia, Zambia (Collaboration)
- University of Zimbabwe, Zimbabwe (Collaboration)
- University of Ilorin Teaching Hospital, Nigeria (Collaboration)
- Radboud University Nijmegen, Netherlands (Collaboration)
- Biomedical Research and Training Inst, Zimbabwe (Collaboration)
- Kenyan Institute for Medical Research (KEMRI) (Collaboration)
- Liverpool School of Tropical Medicine (Collaboration)
Publications
Mangtani P
(2018)
The duration of protection of school-aged BCG vaccination in England: a population-based case-control study.
in International journal of epidemiology
Hargreaves JR
(2015)
Authors' Response to: Deworming externalities and school impacts in Kenya.
in International journal of epidemiology
Houweling TAJ
(2019)
A prediction model for neonatal mortality in low- and middle-income countries: an analysis of data from population surveillance sites in India, Nepal and Bangladesh.
in International journal of epidemiology
Lule SA
(2019)
Are birthweight and postnatal weight gain in childhood associated with blood pressure in early adolescence? Results from a Ugandan birth cohort.
in International journal of epidemiology
Trilok-Kumar G
(2015)
Effects of vitamin D supplementation in infancy on growth, bone parameters, body composition and gross motor development at age 3-6 years: follow-up of a randomized controlled trial.
in International journal of epidemiology
Kuteesa MO
(2020)
Epidemiology of Alcohol Misuse and Illicit Drug Use Among Young People Aged 15-24 Years in Fishing Communities in Uganda.
in International journal of environmental research and public health
Alexander NDE
(2020)
Spatiotemporal Analysis of the Population Risk of Congenital Microcephaly in Pernambuco State, Brazil.
in International journal of environmental research and public health
Francis JM
(2015)
Validation of the MINI (DSM IV) Tool for the Assessment of Alcohol Dependence among Young People in Northern Tanzania Using the Alcohol Biomarker Phosphatidylethanol (PEth).
in International journal of environmental research and public health
Gon G
(2020)
Behavioural Determinants of Hand Washing and Glove Recontamination before Aseptic Procedures at Birth: A Time-and-Motion Study and Survey in Zanzibar Labour Wards
in International Journal of Environmental Research and Public Health
Majonga ED
(2017)
Echocardiographic reference ranges in older children and adolescents in sub-Saharan Africa.
in International journal of cardiology
Wakeham K
(2015)
Trends in Kaposi's sarcoma-associated Herpesvirus antibodies prior to the development of HIV-associated Kaposi's sarcoma: a nested case-control study.
in International journal of cancer
Ibe OP
(2015)
Quality of care for the treatment for uncomplicated malaria in South-East Nigeria: how important is socioeconomic status?
in International journal for equity in health
Mkumbo E
(2014)
Innovation in supervision and support of community health workers for better newborn survival in southern Tanzania.
in International health
Tusting LS
(2016)
Why is malaria associated with poverty? Findings from a cohort study in rural Uganda.
in Infectious diseases of poverty
Ejo M
(2015)
First insights into circulating Mycobacterium tuberculosis complex lineages and drug resistance in Guinea.
in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Morris U
(2015)
Characterising temporal trends in asymptomatic Plasmodium infections and transporter polymorphisms during transition from high to low transmission in Zanzibar, 2005-2013.
in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Marais E
(2014)
Treatment outcomes of multidrug-resistant tuberculosis patients in Gauteng, South Africa.
in Infection
Dziva Chikwari C
(2018)
Community health worker support to improve HIV treatment outcomes for older children and adolescents in Zimbabwe: a process evaluation of the ZENITH trial.
in Implementation science : IS
Waiswa P
(2017)
Effects of the EQUIP quasi-experimental study testing a collaborative quality improvement approach for maternal and newborn health care in Tanzania and Uganda.
in Implementation science : IS
Marchant T
(2014)
The use of continuous surveys to generate and continuously report high quality timely maternal and newborn health data at the district level in Tanzania and Uganda.
in Implementation science : IS
Hanson C
(2014)
Expanded Quality Management Using Information Power (EQUIP): protocol for a quasi-experimental study to improve maternal and newborn health in Tanzania and Uganda.
in Implementation science : IS
Crook AM
(2014)
Injectable and oral contraceptives and risk of HIV acquisition in women: an analysis of data from the MDP301 trial.
in Human reproduction (Oxford, England)
Mangtani P
(2017)
Observational study to estimate the changes in the effectiveness of bacillus Calmette-Guérin (BCG) vaccination with time since vaccination for preventing tuberculosis in the UK.
in Health technology assessment (Winchester, England)
Busza J
(2018)
The role of community health workers in improving HIV treatment outcomes in children: lessons learned from the ZENITH trial in Zimbabwe.
in Health policy and planning
Powell-Jackson T
(2018)
Trials and tribulations: cross-learning from the practices of epidemiologists and economists in the evaluation of public health interventions.
in Health policy and planning
Mudzengi D
(2017)
The patient costs of care for those with TB and HIV: a cross-sectional study from South Africa.
in Health policy and planning
Tancred T
(2018)
How people-centred health systems can reach the grassroots: experiences implementing community-level quality improvement in rural Tanzania and Uganda.
in Health policy and planning
Pitt C
(2017)
Large-scale delivery of seasonal malaria chemoprevention to children under 10 in Senegal: an economic analysis.
in Health policy and planning
Palafox B
(2016)
Prices and mark-ups on antimalarials: evidence from nationally representative studies in six malaria-endemic countries.
in Health policy and planning
Opwora A
(2015)
Implementation of patient charges at primary care facilities in Kenya: implications of low adherence to user fee policy for users and facility revenue.
in Health policy and planning
Hargreaves JR
(2016)
Measuring implementation strength: lessons from the evaluation of public health strategies in low- and middle-income settings.
in Health policy and planning
Sweeney S
(2016)
Methodological Issues to Consider When Collecting Data to Estimate Poverty Impact in Economic Evaluations in Low-income and Middle-income Countries.
in Health economics
Thomas CC
(2016)
The 12-item WHO Disability Assessment Schedule II as an outcome measure for treatment of common mental disorders.
in Global mental health (Cambridge, England)
Mavhu W
(2016)
Safety, Acceptability, and Feasibility of Early Infant Male Circumcision Conducted by Nurse-Midwives Using the AccuCirc Device: Results of a Field Study in Zimbabwe.
in Global health, science and practice
Chirwa T
(2013)
Estimating the extent of household contact misclassification with index cases of disease in longitudinal studies using a stochastic simulation model.
in Global health action
Geary RS
(2015)
Evaluating youth-friendly health services: young people's perspectives from a simulated client study in urban South Africa.
in Global health action
Shinde S
(2017)
The development and pilot testing of a multicomponent health promotion intervention (SEHER) for secondary schools in Bihar, India.
in Global health action
Yamanashi H
(2018)
Association between atherosclerosis and handgrip strength in non-hypertensive populations in India and Japan.
in Geriatrics & gerontology international
Girardi F
(2018)
Risks of breast or ovarian cancer in BRCA1 or BRCA2 predictive test negatives: findings from the EMBRACE study.
in Genetics in medicine : official journal of the American College of Medical Genetics
Stockdale L
(2019)
Cross-sectional study of IgG antibody levels to invasive nontyphoidal Salmonella LPS O-antigen with age in Uganda.
in Gates open research
| Description | Combining Indoor Residual Spraying and Insecticidal Long Lasting Nets: presentation to WHO Malaria Advisory Committee |
| Geographic Reach | Africa |
| Policy Influence Type | Participation in a guidance/advisory committee |
| URL | http://www.who.int/malaria/publications/atoz/who-guidance-combining-irs_llins-mar2014.pdf |
| Description | Comment to European Medicine Agency on 'Questions and answers on Data Monitoring Committees issues' (EMA/492010/2018) |
| Geographic Reach | Europe |
| Policy Influence Type | Contribution to a national consultation/review |
| Description | Deployment of pyrethroid-PBO nets |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Citation in other policy documents |
| Impact | Deployment of pyrethroid-PBO nets in areas where the main malaria vector(s) have pyrethroid resistance |
| URL | http://apps.who.int/iris/bitstream/10665/258939/1/WHO-HTM-GMP-2017.17-eng.pdf?ua=1 |
| Guideline Title | Ebola Virus Disease (EVD) Information for Clinicians in U.S. Healthcare Settings |
| Description | Ebola Clinical Management |
| Geographic Reach | North America |
| Policy Influence Type | Citation in clinical guidelines |
| URL | http://www.cdc.gov/vhf/ebola/healthcare-us/preparing/clinicians.html |
| Description | HIV self-testing WHO prequalification |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Note that Oraquick was PQed in 2017 and INSTI in 2018 - one of the goals of the STAR project was to develop a market for HIV Self Testing approved by regulatory bodies. https://globenewswire.com/news-release/2018/11/28/1658183/0/en/INSTI-HIV-Self-Test-Earns-WHO-Prequalification-Status-for-Home-Testing.html and http://phx.corporate-ir.net/phoenix.zhtml?c=99740&p=irol-newsArticle_print&ID=2287929) |
| URL | https://globenewswire.com/news-release/2018/11/28/1658183/0/en/INSTI-HIV-Self-Test-Earns-WHO-Prequal... |
| Description | HIV services in Zambia and S Africa |
| Geographic Reach | Africa |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Influenced training of practitioners or researchers delivering HIV services in Zambia and S Africa. |
| Description | Membership of WHO Vector Control Advisory Group |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| URL | http://www.who.int/neglected_diseases/vector_ecology/VCAG/en |
| Description | REMSTART trial |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Citation in other policy documents |
| URL | http://www.who.int/hiv/pub/guidelines/advanced-HIV-disease/en/ |
| Description | The Friendship Bench |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | A recently carried out randomized control trial showed that the Friendship Bench can deliver a successful, culturally acceptable and reliable treatment program for depression on a primary care level (Chibanda, D, Bowers, T, Verhey, R, Rusakaniko, S, Abas, M, Weiss, H A, Araya, R. The Friendship Bench programme: a cluster randomised controlled trial of a brief psychological intervention for common mental disorders delivered by lay health workers in Zimbabwe. International journal of mental health systems 2015a; 9, 21). It also addresses the stigma of mental illness in society, and the training of lay workers to deliver problem solving therapy helps address the deficit of mental health specialists in Zimbabwe. |
| URL | http://www.friendshipbenchzimbabwe.org |
| Description | WHO Vector Control Advisory Group |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| URL | http://www.who.int/neglected_diseases/vector_ecology/VCAG/en/ |
| Description | A comparative trial of seasonal vaccination with the malaria vaccine RTS,S/AS01, seasonal malaria chemoprevention and the two interventions combined |
| Amount | £3,491,906 (GBP) |
| Funding ID | MR/P006876/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 06/2020 |
| Description | ACCESS-SMC activities |
| Amount | £308,900 (GBP) |
| Organisation | Malaria Consortium Africa, Kampala |
| Sector | Charity/Non Profit |
| Country | Uganda |
| Start | 11/2017 |
| End | 02/2019 |
| Description | Adolescent 360 Evaluation |
| Amount | $479,341 (USD) |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 03/2016 |
| End | 08/2021 |
| Description | Advances in approaches to optimise testing for sexually transmitted infections |
| Amount | £36,552 (GBP) |
| Organisation | Public Health England |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2018 |
| End | 07/2019 |
| Description | Africa Centre Collaborations Fund |
| Amount | £9,000 (GBP) |
| Funding ID | ISSF/ADDE814710 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2014 |
| End | 06/2015 |
| Description | AmBisone |
| Amount | £10,677 (GBP) |
| Organisation | Médecins Sans Frontières (MSF) |
| Sector | Charity/Non Profit |
| Country | France |
| Start | 08/2016 |
| End | 03/2018 |
| Description | Aurum Institute - Highly TB exposed, persistently uninfected South African gold miners: HETU study |
| Amount | $971,347 (USD) |
| Organisation | Aurum Institute |
| Sector | Charity/Non Profit |
| Country | South Africa |
| Start | 11/2014 |
| End | 12/2016 |
| Description | BMFG - China Gates |
| Amount | $418,871 (USD) |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 11/2014 |
| End | 09/2019 |
| Description | BMGF - Penn State Uni (Eave Tubes Trial) |
| Amount | $938,000 (USD) |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 11/2015 |
| End | 11/2018 |
| Description | CDC/Fiotec Zika project |
| Amount | $184,000 (USD) |
| Organisation | Centers for Disease Control and Prevention (CDC) |
| Sector | Public |
| Country | United States |
| Start | 04/2017 |
| End | 08/2018 |
| Description | CHIDO Trial |
| Amount | $54,941 (USD) |
| Organisation | Centre for Sexual Health and HIV AIDS Research Zimbabwe (CeSHHAR Zimbabwe) |
| Sector | Charity/Non Profit |
| Country | Zimbabwe |
| Start | 01/2016 |
| End | 12/2017 |
| Description | Challenge TB (WHIP3TB Aurum) |
| Amount | $14,264,118 (USD) |
| Funding ID | AID-OAA-A-14-00029 |
| Organisation | United States Agency for International Development |
| Sector | Public |
| Country | United States |
| Start | 03/2016 |
| End | 09/2019 |
| Description | Cluster randomized trial of the Zvandiri programme |
| Amount | £36,578 (GBP) |
| Organisation | Viiv Healthcare |
| Sector | Private |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 12/2018 |
| Description | Combined HIV African Prevention Study: On demand Truvada and F/TAF Pre-exposure and Post exposure prophylaxis to protect adolescents from HIV |
| Amount | € 2,999,999 (EUR) |
| Funding ID | RIA2016MC-1616 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 03/2018 |
| End | 03/2021 |
| Description | DIAMA |
| Amount | € 2,967,202 (EUR) |
| Funding ID | DRIA2014-326 |
| Organisation | Sixth Framework Programme (FP6) |
| Department | European and Developing Countries Clinical Trials Partnership |
| Sector | Public |
| Country | Netherlands |
| Start | 05/2016 |
| End | 05/2021 |
| Description | DNDI Technical agreement (AfriCoLeish II) |
| Amount | £37,000 (GBP) |
| Organisation | Drugs for Neglected Diseases initiative (DNDi) |
| Sector | Charity/Non Profit |
| Country | Switzerland |
| Start | 03/2017 |
| End | 03/2018 |
| Description | Data Collection & Analysis of the Zimbabwe & the Friendship Bench: Deployment of Services for Formative Efforts to Understand Mental Health Issues among HIV-infected Adolescents Project Research Findings |
| Amount | $14,000 (USD) |
| Organisation | United States President's Emergency Plan for AIDS Relief |
| Sector | Public |
| Country | United States |
| Start | 03/2017 |
| End | 09/2018 |
| Description | EU FP7 Theme: AfriCoLeish |
| Amount | € 3,000,000 (EUR) |
| Funding ID | 305178 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 01/2013 |
| End | 12/2016 |
| Description | Effects of metronidazole plus intermittent preventive treatment of malaria in pregnancy on birth outcomes: a randomised controlled trial in Zambia. |
| Amount | £2,496,504 (GBP) |
| Funding ID | MR/S004998/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2018 |
| End | 10/2022 |
| Description | Electronic Data Capture to support rapid epidemiological research and vaccine trials during: Stage 2 |
| Amount | £539,143 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2020 |
| Description | Epidemiological and statistical research on health problems of low and middle-income countries: MRC Tropical Epidemiology Group (TEG) |
| Amount | £4,128,086 (GBP) |
| Funding ID | MR/R010161/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2018 |
| End | 10/2023 |
| Description | GSK Fellowships |
| Amount | £184,050 (GBP) |
| Organisation | GlaxoSmithKline (GSK) |
| Sector | Private |
| Country | Global |
| Start | 03/2018 |
| End | 08/2022 |
| Description | INTREPID II |
| Amount | £279,812 (GBP) |
| Funding ID | MR/P025927/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2017 |
| End | 09/2022 |
| Description | Investigation of HEV transmission dynamics and epidemic evolution to improve outbreak control efforts among emergency affected populations |
| Amount | $11,687 (USD) |
| Organisation | CDC Foundation |
| Sector | Public |
| Country | United States |
| Start | 12/2015 |
| End | 12/2016 |
| Description | Joint Global Health Trials |
| Amount | £2,986,615 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2016 |
| End | 02/2021 |
| Description | Joint Global Health Trials (MENISCUS-2) |
| Amount | £203,351 (GBP) |
| Funding ID | MR/P020283/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 12/2018 |
| Description | Joint Global Health Trials 2013 |
| Amount | £836,321 (GBP) |
| Funding ID | MR/L00433X/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2013 |
| End | 05/2016 |
| Description | Joint Global Health Trials 2013 |
| Amount | £1,856,394 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2014 |
| End | 09/2017 |
| Description | Joint Global Health Trials Development Grant |
| Amount | £200,000 (GBP) |
| Funding ID | MR/P020283/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 10/2018 |
| Description | MRC Adolescent Health Call (Friendship Bench) |
| Amount | £560,269 (GBP) |
| Funding ID | MR/P012485/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 12/2018 |
| Description | MSF - TB PRACTECAL |
| Amount | £542,440 (GBP) |
| Organisation | Médecins Sans Frontières (MSF) |
| Sector | Charity/Non Profit |
| Country | France |
| Start | 09/2013 |
| End | 12/2022 |
| Description | MSF SAM Trial |
| Amount | £32,600 (GBP) |
| Organisation | Médecins Sans Frontières (MSF) |
| Sector | Charity/Non Profit |
| Country | France |
| Start | 12/2017 |
| End | 12/2019 |
| Description | Mass drug administration of ivermectin and dihydroartemisinin-piperaquine as an additional intervention for malaria elimination |
| Amount | £2,057,637 (GBP) |
| Funding ID | MC_EX_MR/R006075/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2017 |
| End | 01/2021 |
| Description | Master's Fellowship in Epidemiology and Medical Statistics |
| Amount | £119,985 (GBP) |
| Organisation | Sixth Framework Programme (FP6) |
| Department | European and Developing Countries Clinical Trials Partnership |
| Sector | Public |
| Country | Netherlands |
| Start | 08/2014 |
| End | 09/2016 |
| Description | Master's Fellowship in Epidemiology and Medical Statistics |
| Amount | £119,985 (GBP) |
| Organisation | Sixth Framework Programme (FP6) |
| Department | European and Developing Countries Clinical Trials Partnership |
| Sector | Public |
| Country | Netherlands |
| Start | 09/2014 |
| End | 09/2016 |
| Description | Master's Fellowship in Epidemiology and Medical Statistics |
| Amount | £116,925 (GBP) |
| Organisation | Sixth Framework Programme (FP6) |
| Department | European and Developing Countries Clinical Trials Partnership |
| Sector | Public |
| Country | Netherlands |
| Start | 08/2014 |
| End | 09/2016 |
| Description | New Investigator Research Grant - Suzanna Francis |
| Amount | £917,566 (GBP) |
| Funding ID | MR/N023692/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2016 |
| End | 06/2019 |
| Description | Newton Household Screening for TB |
| Amount | £57,297 (GBP) |
| Organisation | Medical Research Council of South Africa (MRC) |
| Sector | Public |
| Country | South Africa |
| Start | 04/2016 |
| End | 12/2018 |
| Description | PRIDE (PRemIum for aDolEscents). |
| Amount | £3,715,770 (GBP) |
| Funding ID | 106919/A/15/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 10/2020 |
| Description | Public Health Intervention Development Scheme |
| Amount | £143,663 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2014 |
| End | 10/2014 |
| Description | Public Health Intervention Development Scheme |
| Amount | £150,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2014 |
| End | 07/2015 |
| Description | RAFAScreen |
| Amount | € 39,856 (EUR) |
| Organisation | National Tuberculosis Programme of Benin |
| Sector | Public |
| Country | Benin |
| Start | 07/2015 |
| End | 07/2016 |
| Description | RIFASHORT (Joint funded initiatives) |
| Amount | £2,595,670 (GBP) |
| Funding ID | MR/M006127/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2016 |
| End | 12/2019 |
| Description | Research & Innovation Action |
| Amount | € 41,385 (EUR) |
| Funding ID | 666094 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 11/2014 |
| End | 10/2015 |
| Description | Strengthening Capacity to improve Adolescent Health & Wellbeing in Southern Africa |
| Amount | £134,688 (GBP) |
| Organisation | Viiv Healthcare |
| Sector | Private |
| Country | United Kingdom |
| Start | 07/2018 |
| End | 07/2020 |
| Description | Strengthening East and Southern African capacity for menstrual hygiene management (MHM) research |
| Amount | £24,767 (GBP) |
| Organisation | Academy of Medical Sciences (AMS) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2018 |
| End | 08/2019 |
| Description | TE NTD Research for Sightsavers |
| Amount | £91,236 (GBP) |
| Organisation | Sightsavers |
| Sector | Charity/Non Profit |
| Country | Global |
| Start | 12/2014 |
| End | 12/2015 |
| Description | Technical Support for Insecticide Resistance in India |
| Amount | $63,887 (USD) |
| Funding ID | 39312 |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 12/2015 |
| End | 12/2016 |
| Description | Tuberculosis: Innovative Delivery Approaches |
| Amount | $203,358 (USD) |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 11/2014 |
| End | 10/2016 |
| Description | UNITAID Strategic Objective 4: Treatment of Malaria (Round 2) |
| Amount | $67,400,000 (USD) |
| Organisation | World Health Organization (WHO) |
| Department | UNITAID |
| Sector | Public |
| Country | Switzerland |
| Start | 01/2015 |
| End | 12/2018 |
| Description | UNITAID Strategic Objective 6: Preventatives for HIV/Aids, TB and Malaria |
| Amount | $7,480,000 (USD) |
| Organisation | World Health Organization (WHO) |
| Department | UNITAID |
| Sector | Public |
| Country | Switzerland |
| Start | 01/2015 |
| End | 12/2018 |
| Description | UNITAID/PSI STAR Project |
| Amount | $244,169 (USD) |
| Organisation | World Health Organization (WHO) |
| Department | UNITAID |
| Sector | Public |
| Country | Switzerland |
| Start | 09/2015 |
| End | 10/2017 |
| Description | WT Senior Research Fellowship for Eugene Kinyanda |
| Amount | £2,021,099 (GBP) |
| Funding ID | 205069/Z/16/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2017 |
| End | 03/2022 |
| Description | What is the sensitivity, specificity, and unintended consequences of a trial of (nonTB) antibiotics |
| Amount | £68,580 (GBP) |
| Organisation | University of Malawi |
| Sector | Academic/University |
| Country | Malawi |
| Start | 08/2017 |
| End | 08/2020 |
| Description | YATHU YATHU ("For us by us"): A Cluster Randomised Trial of community-based SRH and HIV services for adolescents and young people in Zambia |
| Amount | £2,183,245 (GBP) |
| Funding ID | MR/R022216/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2018 |
| End | 06/2021 |
| Description | Zero TB Baseline & Endline Survey (IRD Pakistan) |
| Amount | $76,124 (USD) |
| Organisation | Global Fund to Fight AIDS, Tuberculosis and Malaria |
| Sector | Charity/Non Profit |
| Country | Switzerland |
| Start | 03/2017 |
| End | 12/2017 |
| Description | Zvandiri Project |
| Amount | £43,147 (GBP) |
| Organisation | Viiv Healthcare |
| Sector | Private |
| Country | United Kingdom |
| Start | 01/2016 |
| End | 12/2016 |
| Title | Statistical methods for stepped wedge trials |
| Description | Developing appropriate methods of analysis for use in stepped wedge trials |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | Adoption of new more appropriate statistical methods that reflect the true uncertainty of trial results |
| Title | ART and HPV |
| Description | Data from a systematic review on ART and HPV infection |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | None yet |
| URL | http://datacompass.lshtm.ac.uk |
| Title | Data for Thinking Healthy Programme India trial (THPP-India) |
| Description | An anonymised dataset of 280 women (one row per woman) who gave informed consent to participate in an individually-randomised, parallel, superiority, controlled trial in Goa, India in 2014-2016. The intervention was an adapted version of the Thinking Healthy Programme, delivered by peers; the control was enhanced usual care. Further details are available in the published protocol and paper. The dataset contains records of variables on stratified randomisation, socio-demographic information, depression and related outcomes, and therapy adherence. Visits occurred at baseline, and 3 and 6 months post-natal. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | none yet |
| URL | http://datacompass.lshtm.ac.uk/id/eprint/793 |
| Title | Data for Thinking Healthy Programme Pakistan trial (THPP-Pakistan) |
| Description | An anonymised dataset of 570 women (one row per woman) who gave informed consent to participate in a cluster randomised, parallel, superiority, controlled trial in Rawalpindi, Pakistan in 2014-2017. The intervention was an adapted version of the Thinking Healthy Programme, delivered by peers; the control was enhanced usual care. Further details are available in the published protocol and paper. The dataset contains records of variables on stratified randomisation and clusters, socio-demographic information, depression and related outcomes, and therapy adherence. Visits occurred at baseline, and 3 and 6 months post-natal. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | None yet |
| URL | http://datacompass.lshtm.ac.uk/id/eprint/794 |
| Title | HC-HIV IPD dataset |
| Description | The HC-HIV IPD database 18 HIV prevention studies, including 37,124 women (43,613 woman-years) and 1,830 incident HIV infections |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | Impact on WHO policy for contraception |
| Title | PREMIUM twelve-month follow-up trial: Clinical Outcomes and Cost-effectiveness dataset from the Counselling for Alcohol Problems (CAP) RCT |
| Description | Datasets for the two PREMIUM trials |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | None yet |
| URL | http://datacompass.lshtm.ac.uk/514/ |
| Title | PREMIUM twelve-month follow-up trial: Clinical Outcomes and Cost-effectiveness dataset from the Healthy Activity Program (HAP) RCT |
| Description | Datasets for the two PREMIUM trials |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | None yet |
| URL | http://datacompass.lshtm.ac.uk/513/ |
| Title | STIMA Dataset |
| Description | Revised database from HC-HIV database that included 18 HIV prevention studies (cohort studies and randomized controlled trials; conducted during 1993±2011), representing >37,000 women, that tested participants for >1 selected STIs or BV at baseline |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | None yet |
| Title | VMB Dataset |
| Description | Combined data from 16SrRNA sequencing, NMR metabolomic and 33 immune protein targets from 221 women |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | None yet |
| Description | 3HPstudy |
| Organisation | Aurum Institute |
| Country | South Africa |
| Sector | Charity/Non Profit |
| PI Contribution | Study design and analysis |
| Collaborator Contribution | Study design, co-ordination, economic modelling, trial recruitment |
| Impact | Multi-disciplinary: public health, health economics, statistics, trial design |
| Start Year | 2015 |
| Description | 3HPstudy |
| Organisation | Johns Hopkins University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Study design and analysis |
| Collaborator Contribution | Study design, co-ordination, economic modelling, trial recruitment |
| Impact | Multi-disciplinary: public health, health economics, statistics, trial design |
| Start Year | 2015 |
| Description | ALERRT |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | study design & analysis |
| Collaborator Contribution | study design & analysis, collaborator meetings |
| Impact | Multi-disciplinary: epidemiology, public health, statistics, clinical trials |
| Start Year | 2018 |
| Description | AMARI |
| Organisation | Addis Ababa University |
| Country | Ethiopia |
| Sector | Academic/University |
| PI Contribution | Steering committee member |
| Collaborator Contribution | Study co-ordination |
| Impact | PhD and post-doctoral researchers enrolled |
| Start Year | 2015 |
| Description | AMARI |
| Organisation | University of Cape Town |
| Country | South Africa |
| Sector | Academic/University |
| PI Contribution | Steering committee member |
| Collaborator Contribution | Study co-ordination |
| Impact | PhD and post-doctoral researchers enrolled |
| Start Year | 2015 |
| Description | AMARI |
| Organisation | University of Malawi |
| Country | Malawi |
| Sector | Academic/University |
| PI Contribution | Steering committee member |
| Collaborator Contribution | Study co-ordination |
| Impact | PhD and post-doctoral researchers enrolled |
| Start Year | 2015 |
| Description | AMARI |
| Organisation | University of Zimbabwe |
| Country | Zimbabwe |
| Sector | Academic/University |
| PI Contribution | Steering committee member |
| Collaborator Contribution | Study co-ordination |
| Impact | PhD and post-doctoral researchers enrolled |
| Start Year | 2015 |
| Description | AZ-SMC trial |
| Organisation | National Center for Scientific and Technological Research (CNRST) |
| Department | Institute of Research in Health Sciences |
| Country | Burkina Faso |
| Sector | Public |
| PI Contribution | Study design, analysis |
| Collaborator Contribution | Clinical, field, lab studies |
| Impact | NEJM paper (DOI: 10.1056/NEJMoa1811400) Multidisciplinary: epidemiology, statistics, clinical trials Informed WHO guidelines on AZ deployment (still in development) |
| Start Year | 2014 |
| Description | AZ-SMC trial |
| Organisation | University of Bamako |
| Department | Malaria Research and Training Centre (MRTC) Bamako |
| Country | Mali |
| Sector | Academic/University |
| PI Contribution | Study design, analysis |
| Collaborator Contribution | Clinical, field, lab studies |
| Impact | NEJM paper (DOI: 10.1056/NEJMoa1811400) Multidisciplinary: epidemiology, statistics, clinical trials Informed WHO guidelines on AZ deployment (still in development) |
| Start Year | 2014 |
| Description | Adolescents 360 |
| Organisation | Avenir Health |
| Country | United States |
| Sector | Private |
| PI Contribution | Principle investigator at LSHTM, study design, analysis |
| Collaborator Contribution | Project management, process evaluation, cost analysis, liaison with implementers |
| Impact | One paper submitted, two are in preparation. Disciplines include qualitative research, health economics, epidemiology |
| Start Year | 2016 |
| Description | Adolescents 360 |
| Organisation | Avenir Health |
| Country | United States |
| Sector | Private |
| PI Contribution | Principle investigator at LSHTM, study design, analysis |
| Collaborator Contribution | Project management, process evaluation, cost analysis, liaison with implementers |
| Impact | Multi-disciplinary: qualitative research, health economics, epidemiology. Four papers published, two papers in preparation, 3 conference presentations. |
| Start Year | 2016 |
| Description | Adolescents 360 |
| Organisation | BOL NIGERIA ! Bclems Outsourcing Limited |
| Sector | Private |
| PI Contribution | Principle investigator at LSHTM, study design, analysis |
| Collaborator Contribution | Project management, process evaluation, cost analysis, liaison with implementers |
| Impact | Multi-disciplinary: qualitative research, health economics, epidemiology. Four papers published, two papers in preparation, 3 conference presentations. |
| Start Year | 2016 |
| Description | Adolescents 360 |
| Organisation | Itad Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Principle investigator at LSHTM, study design, analysis |
| Collaborator Contribution | Project management, process evaluation, cost analysis, liaison with implementers |
| Impact | One paper submitted, two are in preparation. Disciplines include qualitative research, health economics, epidemiology |
| Start Year | 2016 |
| Description | Adolescents 360 |
| Organisation | Itad Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Principle investigator at LSHTM, study design, analysis |
| Collaborator Contribution | Project management, process evaluation, cost analysis, liaison with implementers |
| Impact | Multi-disciplinary: qualitative research, health economics, epidemiology. Four papers published, two papers in preparation, 3 conference presentations. |
| Start Year | 2016 |
| Description | Adolescents 360 |
| Organisation | National Institute for Medical Research, Tanzania |
| Department | Mwanza Intervention Trials Unit (MITU) |
| Country | Tanzania, United Republic of |
| Sector | Public |
| PI Contribution | Principle investigator at LSHTM, study design, analysis |
| Collaborator Contribution | Project management, process evaluation, cost analysis, liaison with implementers |
| Impact | Multi-disciplinary: qualitative research, health economics, epidemiology. Four papers published, two papers in preparation, 3 conference presentations. |
| Start Year | 2016 |
| Description | Adolescents 360 |
| Organisation | National Institute for Medical Research, Tanzania |
| Department | Mwanza Intervention Trials Unit (MITU) |
| Country | Tanzania, United Republic of |
| Sector | Public |
| PI Contribution | Principle investigator at LSHTM, study design, analysis |
| Collaborator Contribution | Project management, process evaluation, cost analysis, liaison with implementers |
| Impact | One paper submitted, two are in preparation. Disciplines include qualitative research, health economics, epidemiology |
| Start Year | 2016 |
| Description | AfricoLeisch Consortium |
| Organisation | Drugs for Neglected Diseases initiative (DNDi) |
| Country | Switzerland |
| Sector | Charity/Non Profit |
| PI Contribution | Statistical lead and data management oversight |
| Collaborator Contribution | Intellectual input and expertise; access to data; capacity building; research dissemination |
| Impact | Treatment trials in progress |
| Start Year | 2013 |
| Description | AfricoLeisch Consortium |
| Organisation | European Commission |
| Country | European Union (EU) |
| Sector | Public |
| PI Contribution | Statistical lead and data management oversight |
| Collaborator Contribution | Intellectual input and expertise; access to data; capacity building; research dissemination |
| Impact | Treatment trials in progress |
| Start Year | 2013 |
| Description | AfricoLeisch Consortium |
| Organisation | Institute of Tropical Medicine Antwerp |
| Country | Belgium |
| Sector | Academic/University |
| PI Contribution | Statistical lead and data management oversight |
| Collaborator Contribution | Intellectual input and expertise; access to data; capacity building; research dissemination |
| Impact | Treatment trials in progress |
| Start Year | 2013 |
| Description | AfricoLeisch Consortium |
| Organisation | Médecins Sans Frontières (MSF) |
| Country | France |
| Sector | Charity/Non Profit |
| PI Contribution | Statistical lead and data management oversight |
| Collaborator Contribution | Intellectual input and expertise; access to data; capacity building; research dissemination |
| Impact | Treatment trials in progress |
| Start Year | 2013 |
| Description | AfricoLeisch Consortium |
| Organisation | University of Gondar |
| Country | Ethiopia |
| Sector | Academic/University |
| PI Contribution | Statistical lead and data management oversight |
| Collaborator Contribution | Intellectual input and expertise; access to data; capacity building; research dissemination |
| Impact | Treatment trials in progress |
| Start Year | 2013 |
| Description | AfricoLeisch Consortium |
| Organisation | University of Khartoum |
| Country | Sudan |
| Sector | Academic/University |
| PI Contribution | Statistical lead and data management oversight |
| Collaborator Contribution | Intellectual input and expertise; access to data; capacity building; research dissemination |
| Impact | Treatment trials in progress |
| Start Year | 2013 |
| Description | Assessing the impact of the introduction of pneumococcal conjugate vaccine into the childhood vaccine programme |
| Organisation | Wellcome Trust |
| Department | KEMRI-Wellcome Trust Research Programme |
| Country | Kenya |
| Sector | Academic/University |
| PI Contribution | Providing statistical support |
| Collaborator Contribution | Principal investiagors and data collection |
| Impact | Paper on efficacy of different pneumococcal conjugate vaccine schedules against pneumonia, hospitalisation, and mortality in the Gambia published in Vaccine (2014) |
| Start Year | 2014 |
| Description | Associations between latent TB infection in mothers and infant immune response to immunisations |
| Organisation | University of Malawi |
| Country | Malawi |
| Sector | Academic/University |
| PI Contribution | Statistical contribution to trial design. We will be supervising data analysis going forward. |
| Collaborator Contribution | Significant intellectual input and mutual exchange of ideas |
| Impact | None yet. |
| Start Year | 2014 |
| Description | B-GAP |
| Organisation | Biomedical Research and Training Institute (BRTI) |
| Country | Zimbabwe |
| Sector | Charity/Non Profit |
| PI Contribution | Study design and analysis |
| Collaborator Contribution | study design; coordination; field work; economic modelling; |
| Impact | None yet. |
| Start Year | 2017 |
| Description | CADDE (UK-Brazil) |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Study design and analysis |
| Collaborator Contribution | As previous, plus field and lab work. |
| Impact | Multi-disciplinary: epidemiology, ecology, entomology, virology, GIS, statistics, public health. |
| Start Year | 2018 |
| Description | CHIDO trial |
| Organisation | Centre for Sexual Health and HIV AIDS Research Zimbabwe (CeSHHAR Zimbabwe) |
| Country | Zimbabwe |
| Sector | Charity/Non Profit |
| PI Contribution | Trial design and analysis |
| Collaborator Contribution | Trial design and co-ordination |
| Impact | Multi-disciplinary: epidemiology, public health |
| Start Year | 2015 |
| Description | CHIEDZA |
| Organisation | Biomedical Research and Training Institute (BRTI) |
| Country | Zimbabwe |
| Sector | Charity/Non Profit |
| PI Contribution | Study design and analysis |
| Collaborator Contribution | study design; coordination; field work; economic modelling; |
| Impact | No outputs as yet. Collaboration is multi disciplinary including clinical trials, epidemiology, public health, statistics. |
| Start Year | 2016 |
| Description | CMV immunology |
| Organisation | University of Oxford |
| Department | Nuffield Department of Experimental Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | statistical analysis |
| Collaborator Contribution | data collection, lab analysis |
| Impact | paper in Clinical Infectious Diseases, 2 others being written, Multi-disciplinary: immunogenetics, epidemiology |
| Start Year | 2017 |
| Description | COSTOP trial |
| Organisation | MRC/UVRI Uganda Research Unit on AIDS |
| Country | Uganda |
| Sector | Public |
| PI Contribution | Design, implementation, analysis, interpret |
| Collaborator Contribution | Design, implementation, analysis, interpret |
| Impact | Seven papers; 1 oral presentation at CROI 2015 Multidisciplinary: Clinical medicine, epidemiology, qualitative research |
| Start Year | 2010 |
| Description | CRT - creation strategies to increase voluntary medical male circumcision uptake in Zimbabwe |
| Organisation | Centre for Sexual Health and HIV AIDS Research Zimbabwe (CeSHHAR Zimbabwe) |
| Country | Zimbabwe |
| Sector | Charity/Non Profit |
| PI Contribution | Statistical support |
| Collaborator Contribution | Study coordination |
| Impact | Multi-disciplinary: Epidemiology, economics, qualitative |
| Start Year | 2018 |
| Description | CRT - creation strategies to increase voluntary medical male circumcision uptake in Zimbabwe |
| Organisation | Zimbabwe Population Services International (PSI) |
| Country | Zimbabwe |
| Sector | Charity/Non Profit |
| PI Contribution | Statistical support |
| Collaborator Contribution | Study coordination |
| Impact | Multi-disciplinary: Epidemiology, economics, qualitative |
| Start Year | 2018 |
| Description | CRT of an intensified TB/HIV prevention intervention in Malawi |
| Organisation | Wellcome Trust |
| Department | Malawi-Liverpool Wellcome Trust Clinical Research Programme |
| Country | Malawi |
| Sector | Academic/University |
| PI Contribution | Contributed to trial design, statistical support, data analysis |
| Collaborator Contribution | Trial leadership and all other aspects |
| Impact | Intervention evaluation period is complete and final survey (HIV prevalence) is underway. Trial analysis is ongoing. Paper on a sub-trial of home-based versus community-based initiation of HIV care published in JAMA (2014). |
| Start Year | 2010 |
| Description | CRT of intensive versus standard anthelminthic treatment and effects on allergy-related health outcomes |
| Organisation | Medical Research Council (MRC) |
| Department | MRC/UVRI and LSHTM Research Unit Uganda |
| Country | Uganda |
| Sector | Academic/University |
| PI Contribution | Contributed to trial design. Currently leading statistical analysis |
| Collaborator Contribution | Trial leadership and all other aspects |
| Impact | Protocol paper submitted to Trials, baseline findings presented at the European Academy of Allergy and Clinical Immunology (EAACI) conference in June 2014. Intervention is currently ongoing. |
| Start Year | 2011 |
| Description | Capacity Development |
| Organisation | Xinjiang Medical University |
| Department | Department of Epidemiology and Biostatistics |
| Country | China |
| Sector | Academic/University |
| PI Contribution | Training in Epidemiology |
| Collaborator Contribution | Providing research data |
| Impact | Training programme established between Xinjiang and LSHTM |
| Start Year | 2013 |
| Description | Clinical Trial: HIV combination prevention (PopArt) |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Chief Investigator; Trial design; Protocol development; Trial Statistician; Supervision; Administration |
| Collaborator Contribution | Trial is carried out in partnership with NIH HIV Prevention Trials Network; Trial management, laboratory activities and data management and analysis supported by HPTN Core, Network Laboratory and Data and Statistics Center; Field work coordinated at Zambart and DTTC; Modelling and economics components coordinated by Imperial College. |
| Impact | Funding for trial secured, research group established, protocol version 1.0 approved, IRB submissions |
| Start Year | 2011 |
| Description | Clinical Trial: HIV combination prevention (PopArt) |
| Organisation | National Institutes of Health (NIH) |
| Department | HIV Prevention Trials Network HPTN |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | Chief Investigator; Trial design; Protocol development; Trial Statistician; Supervision; Administration |
| Collaborator Contribution | Trial is carried out in partnership with NIH HIV Prevention Trials Network; Trial management, laboratory activities and data management and analysis supported by HPTN Core, Network Laboratory and Data and Statistics Center; Field work coordinated at Zambart and DTTC; Modelling and economics components coordinated by Imperial College. |
| Impact | Funding for trial secured, research group established, protocol version 1.0 approved, IRB submissions |
| Start Year | 2011 |
| Description | Clinical Trial: HIV combination prevention (PopArt) |
| Organisation | University of Stellenbosch |
| Department | Desmond Tutu TB Centre |
| Country | South Africa |
| Sector | Academic/University |
| PI Contribution | Chief Investigator; Trial design; Protocol development; Trial Statistician; Supervision; Administration |
| Collaborator Contribution | Trial is carried out in partnership with NIH HIV Prevention Trials Network; Trial management, laboratory activities and data management and analysis supported by HPTN Core, Network Laboratory and Data and Statistics Center; Field work coordinated at Zambart and DTTC; Modelling and economics components coordinated by Imperial College. |
| Impact | Funding for trial secured, research group established, protocol version 1.0 approved, IRB submissions |
| Start Year | 2011 |
| Description | Clinical Trial: HIV combination prevention (PopArt) |
| Organisation | Zambia AIDS Related Tuberculosis |
| Country | Zambia |
| Sector | Academic/University |
| PI Contribution | Chief Investigator; Trial design; Protocol development; Trial Statistician; Supervision; Administration |
| Collaborator Contribution | Trial is carried out in partnership with NIH HIV Prevention Trials Network; Trial management, laboratory activities and data management and analysis supported by HPTN Core, Network Laboratory and Data and Statistics Center; Field work coordinated at Zambart and DTTC; Modelling and economics components coordinated by Imperial College. |
| Impact | Funding for trial secured, research group established, protocol version 1.0 approved, IRB submissions |
| Start Year | 2011 |
| Description | Clinical Trial: TB Fast Track: a cluster randomised trial to evaluate the effect of a point-of-care TB test-and-treat algorithm on early mortality in people with HIV accessing ART |
| Organisation | Aurum Institute |
| Country | South Africa |
| Sector | Charity/Non Profit |
| PI Contribution | Contributed to trial design, statistical support, data analysis |
| Collaborator Contribution | Significant intellectual input and exchange of ideas |
| Impact | Funding for trial secured; research group established; protocol and CRFs drafted; trial started. Recruitment to end in Dec 2014. Symposium at the Union TB conference in Barcelona 2014 on empiric TB treatment organised by TB Fast Track investigators |
| Start Year | 2012 |
| Description | Clinical Trial: TB Fast Track: a cluster randomised trial to evaluate the effect of a point-of-care TB test-and-treat algorithm on early mortality in people with HIV accessing ART |
| Organisation | Foundation for Professional Development |
| Country | South Africa |
| Sector | Charity/Non Profit |
| PI Contribution | Contributed to trial design, statistical support, data analysis |
| Collaborator Contribution | Significant intellectual input and exchange of ideas |
| Impact | Funding for trial secured; research group established; protocol and CRFs drafted; trial started. Recruitment to end in Dec 2014. Symposium at the Union TB conference in Barcelona 2014 on empiric TB treatment organised by TB Fast Track investigators |
| Start Year | 2012 |
| Description | Clinical Trial: TB Fast Track: a cluster randomised trial to evaluate the effect of a point-of-care TB test-and-treat algorithm on early mortality in people with HIV accessing ART |
| Organisation | Johns Hopkins University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Contributed to trial design, statistical support, data analysis |
| Collaborator Contribution | Significant intellectual input and exchange of ideas |
| Impact | Funding for trial secured; research group established; protocol and CRFs drafted; trial started. Recruitment to end in Dec 2014. Symposium at the Union TB conference in Barcelona 2014 on empiric TB treatment organised by TB Fast Track investigators |
| Start Year | 2012 |
| Description | Clinical trial: Impact of helminths on the response to immunisation and on incidence of infection and disease in childhood |
| Organisation | Entebbe District Hospital |
| Country | Uganda |
| Sector | Hospitals |
| PI Contribution | Designed and supported randomised trial evaluating 3 interventions at 2 stages. |
| Collaborator Contribution | Trial leadership; Access to study cohort |
| Impact | Trial found that anthelminthic treatment during pregnancy increased incidence of eczema in childhood, and that quarterly anthelminthic treatment during early childhood decreased the incidence of malaria. Apart from this, there were no other effects of anthelminthic treatment during pregnancy and childhood on responses to immunisations, incidence of infectious diseases, growth or anaemia. Main trial results have been published in the Lancet and in PLoS ONE. Children are now being follow-up to 10 years old. |
| Start Year | 2006 |
| Description | Clinical trial: Impact of helminths on the response to immunisation and on incidence of infection and disease in childhood |
| Organisation | MRC/UVRI Uganda Research Unit on AIDS |
| Country | Uganda |
| Sector | Public |
| PI Contribution | Designed and supported randomised trial evaluating 3 interventions at 2 stages. |
| Collaborator Contribution | Trial leadership; Access to study cohort |
| Impact | Trial found that anthelminthic treatment during pregnancy increased incidence of eczema in childhood, and that quarterly anthelminthic treatment during early childhood decreased the incidence of malaria. Apart from this, there were no other effects of anthelminthic treatment during pregnancy and childhood on responses to immunisations, incidence of infectious diseases, growth or anaemia. Main trial results have been published in the Lancet and in PLoS ONE. Children are now being follow-up to 10 years old. |
| Start Year | 2006 |
| Description | Clinical trial: Implementation and evaluation of an optimized model for scaling up TB/HIV integration at primary care clinics in Ekurhuleni north sub-district, South Africa |
| Organisation | Aurum Institute |
| Country | South Africa |
| Sector | Charity/Non Profit |
| PI Contribution | Contributed to trial design, statistical support, data analysis |
| Collaborator Contribution | Significant intellectual input and exchange of ideas |
| Impact | Protocol and CRFs drafted; trial completed and data currently being analysed. Paper published on trial design (Contemporary Clinical Trials 2014) |
| Start Year | 2011 |
| Description | Clinical trial: Microbicides Development Programme |
| Organisation | Medical Research Council (MRC) |
| Department | Microbicides Development Programme |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | PI for Mwanza field site; statistical input to trial |
| Collaborator Contribution | Collaborative involvement in Phase III trial of Pro2000 vaginal microbicide |
| Impact | Successful completion and publication of MDP301 Phase III trial; further publications in progress; capacity building in partner sites in Africa; development of proposal for MDP302 trial |
| Description | Clinical trial: Treatment and prevention strategies for HIV-associated cryptococcal meningitis |
| Organisation | St George's University of London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Trial design and data analysis |
| Collaborator Contribution | Significant intellectual input and mutual exchange of ideas |
| Impact | Findings published in several high impact journals. A second trial is now underway to determine the most effective and sustainable regimens for patients presenting with cryptococcal meningitis in resource-poor settings |
| Start Year | 2006 |
| Description | Clinical trial: Xpert MTB/RIF for diagnosis of tuberculosis: evaluating impact and cost-effectiveness in the routine roll-out in South Africa "Xpert for TB: Evaluating a New Diagnostic" (XTEND) trial and XPHACTOR study |
| Organisation | Aurum Institute |
| Country | South Africa |
| Sector | Charity/Non Profit |
| PI Contribution | Contributed to trial design, statistical support, data analysis |
| Collaborator Contribution | Significant intellectual input and exchange of ideas |
| Impact | Funding for trial secured; research group established; protocol and CRFs drafted; trial started. XTEND trial completed and results presented at CROI (2014) and South Africa TB conference (2014). Main paper under review and other papers in progress. XPHACTOR recruitment and follow-up completed, data currently being analysed. Interim data presented at South Africa TB (2014) and Union TB Conference (2014); Papers in progress. |
| Start Year | 2011 |
| Description | Clinical trial: Xpert MTB/RIF for diagnosis of tuberculosis: evaluating impact and cost-effectiveness in the routine roll-out in South Africa "Xpert for TB: Evaluating a New Diagnostic" (XTEND) trial and XPHACTOR study |
| Organisation | National Health Laboratory Services, South Africa |
| Country | South Africa |
| Sector | Public |
| PI Contribution | Contributed to trial design, statistical support, data analysis |
| Collaborator Contribution | Significant intellectual input and exchange of ideas |
| Impact | Funding for trial secured; research group established; protocol and CRFs drafted; trial started. XTEND trial completed and results presented at CROI (2014) and South Africa TB conference (2014). Main paper under review and other papers in progress. XPHACTOR recruitment and follow-up completed, data currently being analysed. Interim data presented at South Africa TB (2014) and Union TB Conference (2014); Papers in progress. |
| Start Year | 2011 |
| Description | Clinical trial: Xpert MTB/RIF for diagnosis of tuberculosis: evaluating impact and cost-effectiveness in the routine roll-out in South Africa "Xpert for TB: Evaluating a New Diagnostic" (XTEND) trial and XPHACTOR study |
| Organisation | University of Cape Town |
| Country | South Africa |
| Sector | Academic/University |
| PI Contribution | Contributed to trial design, statistical support, data analysis |
| Collaborator Contribution | Significant intellectual input and exchange of ideas |
| Impact | Funding for trial secured; research group established; protocol and CRFs drafted; trial started. XTEND trial completed and results presented at CROI (2014) and South Africa TB conference (2014). Main paper under review and other papers in progress. XPHACTOR recruitment and follow-up completed, data currently being analysed. Interim data presented at South Africa TB (2014) and Union TB Conference (2014); Papers in progress. |
| Start Year | 2011 |
| Description | Clinical trial: Xpert MTB/RIF for diagnosis of tuberculosis: evaluating impact and cost-effectiveness in the routine roll-out in South Africa "Xpert for TB: Evaluating a New Diagnostic" (XTEND) trial and XPHACTOR study |
| Organisation | World Health Organization (WHO) |
| Country | Global |
| Sector | Public |
| PI Contribution | Contributed to trial design, statistical support, data analysis |
| Collaborator Contribution | Significant intellectual input and exchange of ideas |
| Impact | Funding for trial secured; research group established; protocol and CRFs drafted; trial started. XTEND trial completed and results presented at CROI (2014) and South Africa TB conference (2014). Main paper under review and other papers in progress. XPHACTOR recruitment and follow-up completed, data currently being analysed. Interim data presented at South Africa TB (2014) and Union TB Conference (2014); Papers in progress. |
| Start Year | 2011 |
| Description | Collaborative group on the impact of digital technologies on TB |
| Organisation | World Health Organization (WHO) |
| Country | Global |
| Sector | Public |
| PI Contribution | Contributed to a paper titled "Digital health technologies for active TB treatment support: A cost-effectiveness analysis" as part of the collaborative group, led by WHO |
| Collaborator Contribution | WHO lead the collaborative group |
| Impact | One publication submitted to a journal |
| Start Year | 2017 |
| Description | Combined HIV Adolescent PrEP and Prevention Study |
| Organisation | Wits Health Consortium |
| Country | South Africa |
| Sector | Private |
| PI Contribution | Study design, sample size, statistical analysis |
| Collaborator Contribution | Laboratory analysis, field work, data collection, study design, scientific hypothesis |
| Impact | Poster presented at HIVR4P, Oct 2018: http://apps.webofknowledge.com/InboundService.do?customersID=LinksAMR&mode=FullRecord&IsProductCode=Yes?uct=WOS&Init=Yes&Func=Frame&DestFail=http%3A%2F%2Fwww.webofknowledge.com?tion=retrieve&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&SID=C2bwzliNPISkWLdNkIt&UT=WOS%3A000448371600674 Multi-disciplinary: Epidemiology, social science, clinical trial, laboratory |
| Start Year | 2018 |
| Description | DIAMA |
| Organisation | National Hospital of Pneumo-Phtisiology |
| Country | Benin |
| Sector | Hospitals |
| PI Contribution | LSHTM lead on statistical analysis, contribution to data management and paper writing |
| Collaborator Contribution | Coordination, study design, implementation, paper writing |
| Impact | None yet |
| Start Year | 2016 |
| Description | DIVIDS study and follow-ups |
| Organisation | University of Delhi |
| Department | Institute of Home Economics |
| Country | India |
| Sector | Academic/University |
| PI Contribution | Analysis of RCT of vitamin D supplementation to low birth weight term infants. Analysis of follow-up data from 4-5 year olds |
| Collaborator Contribution | Co-ordination of the field work |
| Impact | Analysis of main trial result in BMJ. Follow-up data was published in Int J Epi and BMJ Open. Multi-disciplinary - nutrition. |
| Start Year | 2010 |
| Description | DREAMS evaluation |
| Organisation | African Population and Health Research Center |
| Country | Kenya |
| Sector | Academic/University |
| PI Contribution | co-Principal investigator |
| Collaborator Contribution | Co-design of impact evaluation design, new research questionnaires, lead responsibility for field implementation |
| Impact | Presentations (oral and poster) at AIDS Impact conference 2017 and R4P 2018. Plos One journal supplement with papers reporting historical trends and baseline findings. Protocol paper published. Multi-disciplinary: Epidemiology, Demography, Public Health, Social Science |
| Start Year | 2016 |
| Description | DREAMS evaluation |
| Organisation | Armauer Hansen Research Institute |
| Country | Ethiopia |
| Sector | Charity/Non Profit |
| PI Contribution | co-Principal investigator |
| Collaborator Contribution | Co-design of impact evaluation design, new research questionnaires, lead responsibility for field implementation |
| Impact | Presentations (oral and poster) at AIDS Impact conference 2017 and R4P 2018. Plos One journal supplement with papers reporting historical trends and baseline findings. Protocol paper published. Multi-disciplinary: Epidemiology, Demography, Public Health, Social Science |
| Start Year | 2016 |
| Description | DREAMS evaluation |
| Organisation | Centre for Sexual Health and HIV AIDS Research Zimbabwe (CeSHHAR Zimbabwe) |
| Country | Zimbabwe |
| Sector | Charity/Non Profit |
| PI Contribution | co-Principal investigator |
| Collaborator Contribution | Co-design of impact evaluation design, new research questionnaires, lead responsibility for field implementation |
| Impact | Presentations (oral and poster) at AIDS Impact conference 2017 and R4P 2018. Plos One journal supplement with papers reporting historical trends and baseline findings. Protocol paper published. Multi-disciplinary: Epidemiology, Demography, Public Health, Social Science |
| Start Year | 2016 |
| Description | DREAMS evaluation |
| Organisation | Kenyan Institute for Medical Research (KEMRI) |
| Country | Kenya |
| Sector | Public |
| PI Contribution | co-Principal investigator |
| Collaborator Contribution | Co-design of impact evaluation design, new research questionnaires, lead responsibility for field implementation |
| Impact | Presentations (oral and poster) at AIDS Impact conference 2017 and R4P 2018. Plos One journal supplement with papers reporting historical trends and baseline findings. Protocol paper published. Multi-disciplinary: Epidemiology, Demography, Public Health, Social Science |
| Start Year | 2016 |
| Description | DREAMS evaluation |
| Organisation | United States President's Emergency Plan for AIDS Relief |
| Country | United States |
| Sector | Public |
| PI Contribution | co-Principal investigator |
| Collaborator Contribution | Co-design of impact evaluation design, new research questionnaires, lead responsibility for field implementation |
| Impact | Presentations (oral and poster) at AIDS Impact conference 2017 and R4P 2018. Plos One journal supplement with papers reporting historical trends and baseline findings. Protocol paper published. Multi-disciplinary: Epidemiology, Demography, Public Health, Social Science |
| Start Year | 2016 |
| Description | Dengue Index |
| Organisation | Khon Kaen University |
| Country | Thailand |
| Sector | Academic/University |
| PI Contribution | Design and analysis of case-control study and cluster-randomized trial |
| Collaborator Contribution | Carrying out clinical and entomological investigations in clinics and homes |
| Impact | Multi-disciplinary: Entomology, public health |
| Start Year | 2016 |
| Description | Dengue Index |
| Organisation | Norwegian University of Life Sciences (NMBU) |
| Country | Norway |
| Sector | Academic/University |
| PI Contribution | Design and analysis of case-control study and cluster-randomized trial |
| Collaborator Contribution | Carrying out clinical and entomological investigations in clinics and homes |
| Impact | Multi-disciplinary: Entomology, public health |
| Start Year | 2016 |
| Description | Design and analysis of clinical trials for the treatment of Visceral Leishmaniasis |
| Organisation | Drugs for Neglected Diseases initiative (DNDi) |
| Country | Switzerland |
| Sector | Charity/Non Profit |
| PI Contribution | Contributed to design and analysis of clinical trials, continued capacity building in data management, study design and analysis methods, preparation of successful grant applications, project management |
| Collaborator Contribution | Sponsorship of clinical trials, intellectual input, project management, leadership |
| Impact | Trials ongoing. Demonstration of ability to conduct rigorous research in the context of a public health emergency and engage affected communities in a volatile stigmatised environment. Multi-disciplinary - Statistics, clinical, public health. |
| Start Year | 2013 |
| Description | Design and analysis of clinical trials for the treatment of Visceral Leishmaniasis |
| Organisation | Institute of Tropical Medicine Antwerp |
| Country | Belgium |
| Sector | Academic/University |
| PI Contribution | Contributed to design and analysis of clinical trials, continued capacity building in data management, study design and analysis methods, preparation of successful grant applications, project management |
| Collaborator Contribution | Sponsorship of clinical trials, intellectual input, project management, leadership |
| Impact | Trials ongoing. Demonstration of ability to conduct rigorous research in the context of a public health emergency and engage affected communities in a volatile stigmatised environment. Multi-disciplinary - Statistics, clinical, public health. |
| Start Year | 2013 |
| Description | Design and analysis of clinical trials for the treatment of Visceral Leishmaniasis |
| Organisation | Leishmaniasis East Africa Platform (LEAP) |
| Country | Sudan |
| Sector | Public |
| PI Contribution | Contributed to design and analysis of clinical trials, continued capacity building in data management, study design and analysis methods, preparation of successful grant applications, project management |
| Collaborator Contribution | Sponsorship of clinical trials, intellectual input, project management, leadership |
| Impact | Trials ongoing. Demonstration of ability to conduct rigorous research in the context of a public health emergency and engage affected communities in a volatile stigmatised environment. Multi-disciplinary - Statistics, clinical, public health. |
| Start Year | 2013 |
| Description | Drought, Poverty and HIV Drug Resistance: threat to resilience in a vulnerable rural settings |
| Organisation | Africa Health Research Institute |
| Country | South Africa |
| Sector | Charity/Non Profit |
| PI Contribution | study design; statistical advice, data linkage; analysis |
| Collaborator Contribution | study design; coordination; field work; spatial epidemiology; economic modelling; climate science |
| Impact | None yet. Multidisciplinary: epidemiology, public health, climate science, biostatistics, qualitative research |
| Start Year | 2017 |
| Description | Drought, Poverty and HIV Drug Resistance: threat to resilience in a vulnerable rural settings |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | study design; statistical advice, data linkage; analysis |
| Collaborator Contribution | study design; coordination; field work; spatial epidemiology; economic modelling; climate science |
| Impact | None yet. Multidisciplinary: epidemiology, public health, climate science, biostatistics, qualitative research |
| Start Year | 2017 |
| Description | Drought, Poverty and HIV Drug Resistance: threat to resilience in a vulnerable rural settings |
| Organisation | University of Sussex |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | study design; statistical advice, data linkage; analysis |
| Collaborator Contribution | study design; coordination; field work; spatial epidemiology; economic modelling; climate science |
| Impact | None yet. Multidisciplinary: epidemiology, public health, climate science, biostatistics, qualitative research |
| Start Year | 2017 |
| Description | EIP trial |
| Organisation | Medical Research Council (MRC) |
| Department | MRC/UVRI and LSHTM Research Unit Uganda |
| Country | Uganda |
| Sector | Academic/University |
| PI Contribution | Trial design and analysis |
| Collaborator Contribution | Trial design and co-ordination |
| Impact | Multi-disciplinary - Epidemiology, public health |
| Start Year | 2017 |
| Description | Eave Tubes |
| Organisation | Cote D'Ivoire's National Institute of Public Health |
| Country | Cote d'Ivoire |
| Sector | Public |
| PI Contribution | Project statistician/epidemiologist- co-design of study and analysis; coordination with sample collection and fieldwork |
| Collaborator Contribution | co-design; development of novel vector control product; field activities; entomological activities; lab analysis of samples |
| Impact | Multi-disciplinary: epidemiology, public health, social science, entomology |
| Start Year | 2016 |
| Description | Eave Tubes |
| Organisation | In2Care BV |
| Country | Netherlands |
| Sector | Private |
| PI Contribution | Project statistician/epidemiologist- co-design of study and analysis; coordination with sample collection and fieldwork |
| Collaborator Contribution | co-design; development of novel vector control product; field activities; entomological activities; lab analysis of samples |
| Impact | Multi-disciplinary: epidemiology, public health, social science, entomology |
| Start Year | 2016 |
| Description | Eave Tubes |
| Organisation | Penn State University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Project statistician/epidemiologist- co-design of study and analysis; coordination with sample collection and fieldwork |
| Collaborator Contribution | co-design; development of novel vector control product; field activities; entomological activities; lab analysis of samples |
| Impact | Multi-disciplinary: epidemiology, public health, social science, entomology |
| Start Year | 2016 |
| Description | Eliminate Dengue Program |
| Organisation | Monash University |
| Department | Eliminate Dengue Program |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Design of cluster randomised trial to evaluate effectiveness of large scale Wolbachia deployments on dengue transmission |
| Collaborator Contribution | Facilitation and hosting of three workshops to design and plan trials in Indonesia and Vietnam |
| Impact | Study protocol and draft manuscript on trial design. Multi-disciplinary - Epidemiology, Entomology, Infectious Disease Control, Statistics, Modelling. |
| Start Year | 2015 |
| Description | Elimination Eight Partnerships |
| Organisation | Elimination Eight |
| Country | Namibia |
| Sector | Private |
| PI Contribution | Technical advice and leadership for malaria elimination in 8 SADC countries |
| Collaborator Contribution | Co-ordination of regional malaria elimnation strategies |
| Impact | Multi-disciplinary: Epidemiology, Public Health |
| Start Year | 2016 |
| Description | Epidemiology of microcephaly and Zika in Pernambuco, Brasil |
| Organisation | Oswaldo Cruz Foundation (Fiocruz) |
| Country | Brazil |
| Sector | Public |
| PI Contribution | Space/time analysis of data on incidence of microcephaly; estimation of incidence of Zika, |
| Collaborator Contribution | Multiple population and hospital-based studies on microcephaly and Zika. |
| Impact | None as yet. |
| Start Year | 2016 |
| Description | Evaluation of an mHealth app for Ebola contact tracing |
| Organisation | Innovations for Poverty Action (IPA) |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | Design & analysis of a smartphone app to improve contact tracing and monitoring during the 2015 Ebola outbreak in Sierra Leone |
| Collaborator Contribution | Development of the app |
| Impact | Final analysis is ongoing. Multi disciplinary - Epidemiology, social science, technology |
| Start Year | 2015 |
| Description | Evaluation of attractant targeted sugar baits for malaria prevention |
| Organisation | University of Bamako |
| Country | Mali |
| Sector | Academic/University |
| PI Contribution | study design, protocol development, trial support, statistical analysis |
| Collaborator Contribution | Entomology, sugar bait technology, fieldwork experience |
| Impact | Multi-disciplinary: epidemiology, entomology, statistics, social science |
| Start Year | 2018 |
| Description | Evaluation of convalescent Plasma for Ebola Virus Disease in Sierra Leone |
| Organisation | Institute of Tropical Medicine Antwerp |
| Country | Belgium |
| Sector | Academic/University |
| PI Contribution | Contributing to design and analysis of clinical trials, preparation of successful grant applications, project management |
| Collaborator Contribution | Sponsorship of clinical trials, intellectual input, project management, leadership |
| Impact | Publication of trial findings in New England Journal of Medicine. Multi-disciplinary - Statistics, clinical, public health. |
| Start Year | 2014 |
| Description | Evaluation of convalescent Plasma for Ebola Virus Disease in Sierra Leone |
| Organisation | University of Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Contributing to design and analysis of clinical trials, preparation of successful grant applications, project management |
| Collaborator Contribution | Sponsorship of clinical trials, intellectual input, project management, leadership |
| Impact | Publication of trial findings in New England Journal of Medicine. Multi-disciplinary - Statistics, clinical, public health. |
| Start Year | 2014 |
| Description | GIS training |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Unit, The Gambia |
| Country | Gambia |
| Sector | Public |
| PI Contribution | Developed material and gave training course at each institution |
| Collaborator Contribution | Fieldwork during training |
| Impact | Multi-disciplinary: GIS, epidemiology, statistics |
| Start Year | 2018 |
| Description | GIS training |
| Organisation | Medical Research Council (MRC) |
| Department | MRC/UVRI and LSHTM Research Unit Uganda |
| Country | Uganda |
| Sector | Academic/University |
| PI Contribution | Developed material and gave training course at each institution |
| Collaborator Contribution | Fieldwork during training |
| Impact | Multi-disciplinary: GIS, epidemiology, statistics |
| Start Year | 2018 |
| Description | GMZ2 Consortium |
| Organisation | Center of Medical Research Lambaréné |
| Country | Gabon |
| Sector | Academic/University |
| PI Contribution | Design and analysis of the GMZ2 malaria vaccine trial |
| Collaborator Contribution | Co-ordination of the field trial |
| Impact | Final efficacy analysis is ongoing. This is a multi centre phase 2b vaccine trial so involves clinical, epidemiological, statistical and laboratory (immunology) expertise. |
| Start Year | 2008 |
| Description | GMZ2 Consortium |
| Organisation | Makerere University College of Health Sciences |
| Country | Uganda |
| Sector | Academic/University |
| PI Contribution | Design and analysis of the GMZ2 malaria vaccine trial |
| Collaborator Contribution | Co-ordination of the field trial |
| Impact | Final efficacy analysis is ongoing. This is a multi centre phase 2b vaccine trial so involves clinical, epidemiological, statistical and laboratory (immunology) expertise. |
| Start Year | 2008 |
| Description | GMZ2 Consortium |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Unit, The Gambia |
| Country | Gambia |
| Sector | Public |
| PI Contribution | Design and analysis of the GMZ2 malaria vaccine trial |
| Collaborator Contribution | Co-ordination of the field trial |
| Impact | Final efficacy analysis is ongoing. This is a multi centre phase 2b vaccine trial so involves clinical, epidemiological, statistical and laboratory (immunology) expertise. |
| Start Year | 2008 |
| Description | GMZ2 Consortium |
| Organisation | Navrongo Health Research Centre (NHRC) |
| Country | Ghana |
| Sector | Academic/University |
| PI Contribution | Design and analysis of the GMZ2 malaria vaccine trial |
| Collaborator Contribution | Co-ordination of the field trial |
| Impact | Final efficacy analysis is ongoing. This is a multi centre phase 2b vaccine trial so involves clinical, epidemiological, statistical and laboratory (immunology) expertise. |
| Start Year | 2008 |
| Description | GMZ2 Consortium |
| Organisation | The Statens Serum Institute (SSI) |
| Country | Denmark |
| Sector | Public |
| PI Contribution | Design and analysis of the GMZ2 malaria vaccine trial |
| Collaborator Contribution | Co-ordination of the field trial |
| Impact | Final efficacy analysis is ongoing. This is a multi centre phase 2b vaccine trial so involves clinical, epidemiological, statistical and laboratory (immunology) expertise. |
| Start Year | 2008 |
| Description | Global mental health trials |
| Organisation | Sangath |
| Country | India |
| Sector | Charity/Non Profit |
| PI Contribution | Statistical and epidemiological collaboration |
| Collaborator Contribution | Leadership and all aspects of the trials |
| Impact | Evidence to support the use of lay health workers in delivering psychosocial interventions in primary care clinics. Multi disciplinary - Epidemiology, statistics, clinical, public health |
| Description | Gnatwork |
| Organisation | The Pirbright Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Setting up grant schemes, reviewing the resultant proposals, and training. |
| Collaborator Contribution | As previous, plus administering the core scheme and the grants awarded. |
| Impact | Multi-disciplinary: epidemiology, entomology, statistics, molecular biology |
| Start Year | 2017 |
| Description | Good Health for Women Project |
| Organisation | MRC/UVRI Uganda Research Unit on AIDS |
| Country | Uganda |
| Sector | Public |
| PI Contribution | Analysis of a long-term cohort of women at high risk of HIV |
| Collaborator Contribution | Study co-ordination |
| Impact | Multi-disciplinary: epidemiology, social science |
| Start Year | 2016 |
| Description | HAYA |
| Organisation | Africa Health Research Institute |
| Country | South Africa |
| Sector | Charity/Non Profit |
| PI Contribution | Suzanna Francis was Principal investigator leading the iGugu project |
| Collaborator Contribution | Study was co-run with partners |
| Impact | 1 paper; 4 conference presentations. Disciplines involved - Epidemiology; Social Science; Laboratory Science |
| Start Year | 2015 |
| Description | HC-HIV IPD |
| Organisation | Family Health International |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | Protocol development and review of analysis and paper |
| Collaborator Contribution | FHI was leading the project and carried out the analysis |
| Impact | 1 paper. Impact: Impacted WHO policy on contraceptive use among women at high risk for HIV |
| Start Year | 2012 |
| Description | HCBV |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Suzanna Francis is principal investigator |
| Collaborator Contribution | 16SrRNA sequencing; metabolomics; Luminex testing; data collection |
| Impact | No outputs yet. Disciplines include Epidemiology; Social Science; Laboratory Science |
| Start Year | 2017 |
| Description | HCBV |
| Organisation | MRC/UVRI Uganda Research Unit on AIDS |
| Country | Uganda |
| Sector | Public |
| PI Contribution | Suzanna Francis is principal investigator |
| Collaborator Contribution | 16SrRNA sequencing; metabolomics; Luminex testing; data collection |
| Impact | No outputs yet. Disciplines include Epidemiology; Social Science; Laboratory Science |
| Start Year | 2017 |
| Description | HCBV |
| Organisation | University of Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Suzanna Francis is principal investigator |
| Collaborator Contribution | 16SrRNA sequencing; metabolomics; Luminex testing; data collection |
| Impact | No outputs yet. Disciplines include Epidemiology; Social Science; Laboratory Science |
| Start Year | 2017 |
| Description | HDTstudy |
| Organisation | Aurum Institute |
| Country | South Africa |
| Sector | Charity/Non Profit |
| PI Contribution | Study design and supervising analysis |
| Collaborator Contribution | Study design, co-ordination, trial recruitment |
| Impact | Multi-disciplinary: statistics, trial design, immunology |
| Start Year | 2016 |
| Description | HIV Drug Resistance Elimination And Management Network |
| Organisation | Africa Health Research Institute |
| Country | South Africa |
| Sector | Charity/Non Profit |
| PI Contribution | study design; statistical advice, data linkage; analysis |
| Collaborator Contribution | study design; coordination; field activities; organisation of workships; |
| Impact | None yet. Multidisciplinary: epidemiology, public health, statistics, qualitative research |
| Start Year | 2017 |
| Description | HIV Drug Resistance Elimination And Management Network |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | study design; statistical advice, data linkage; analysis |
| Collaborator Contribution | study design; coordination; field activities; organisation of workships; |
| Impact | None yet. Multidisciplinary: epidemiology, public health, statistics, qualitative research |
| Start Year | 2017 |
| Description | HIV Drug Resistance Elimination And Management Network |
| Organisation | University of Sussex |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | study design; statistical advice, data linkage; analysis |
| Collaborator Contribution | study design; coordination; field activities; organisation of workships; |
| Impact | None yet. Multidisciplinary: epidemiology, public health, statistics, qualitative research |
| Start Year | 2017 |
| Description | HIV Prevention Trials |
| Organisation | WellcomeTrust Africa Centre |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Statistical collaboration at Africa Centre |
| Collaborator Contribution | Leadership of Africa Centre |
| Impact | Renewal of Africa Centre grant from Wellcome Trust. Multi-disciplinary - Epidemiology, statistics, economics, social science, clinical medicine, molecular biology |
| Start Year | 2014 |
| Description | HIV Self-Testing in AfRica (STAR) |
| Organisation | Centre for Sexual Health and HIV AIDS Research Zimbabwe (CeSHHAR Zimbabwe) |
| Country | Zimbabwe |
| Sector | Charity/Non Profit |
| PI Contribution | Trial design and analysis |
| Collaborator Contribution | Trial design and co-ordination |
| Impact | Multi-disciplinary: epidemiology, public health |
| Start Year | 2015 |
| Description | HIV Self-Testing in AfRica (STAR) |
| Organisation | Liverpool School of Tropical Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Trial design and analysis |
| Collaborator Contribution | Trial design and co-ordination |
| Impact | Multi-disciplinary: epidemiology, public health |
| Start Year | 2015 |
| Description | HIV Self-Testing in AfRica (STAR) |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Trial design and analysis |
| Collaborator Contribution | Trial design and co-ordination |
| Impact | Multi-disciplinary: epidemiology, public health |
| Start Year | 2015 |
| Description | HIV Self-Testing in AfRica (STAR) |
| Organisation | Wellcome Trust |
| Department | Malawi-Liverpool Wellcome Trust Clinical Research Programme |
| Country | Malawi |
| Sector | Academic/University |
| PI Contribution | Trial design and analysis |
| Collaborator Contribution | Trial design and co-ordination |
| Impact | Multi-disciplinary: epidemiology, public health |
| Start Year | 2015 |
| Description | HIV Self-Testing in AfRica (STAR) |
| Organisation | World Health Organization (WHO) |
| Department | UNITAID |
| Country | Switzerland |
| Sector | Public |
| PI Contribution | Trial design and analysis |
| Collaborator Contribution | Trial design and co-ordination |
| Impact | Multi-disciplinary: epidemiology, public health |
| Start Year | 2015 |
| Description | HIV epidemiology in the Middle East and North Africa |
| Organisation | Weill Cornell Medical College in Qatar |
| Country | Qatar |
| Sector | Academic/University |
| PI Contribution | PhD supervision |
| Collaborator Contribution | Analysis and modelling |
| Impact | 4 papers published, details in publications section of submission Multi-disciplinary: epidemiology, modelling |
| Start Year | 2012 |
| Description | HIV self testing: Network distribution for linkage to PrEP and prevention in South Africa (AHRI) |
| Organisation | Africa Health Research Institute |
| Country | South Africa |
| Sector | Charity/Non Profit |
| PI Contribution | study design, sample size, statistical analysis |
| Collaborator Contribution | study design, field activities |
| Impact | Multi-disciplinary: epidemiology, statistics, social science |
| Start Year | 2017 |
| Description | HIV self testing: Network distribution for linkage to PrEP and prevention in South Africa (AHRI) |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | study design, sample size, statistical analysis |
| Collaborator Contribution | study design, field activities |
| Impact | Multi-disciplinary: epidemiology, statistics, social science |
| Start Year | 2017 |
| Description | HIV/VL India |
| Organisation | Médecins Sans Frontières (MSF) |
| Country | France |
| Sector | Charity/Non Profit |
| PI Contribution | Trial design and analysis |
| Collaborator Contribution | Leading clinical trial of drugs against visceral leishmaniasis in HIV co-infected patients |
| Impact | Multi-disciplinary: epidemiology, public health |
| Start Year | 2016 |
| Description | HPV Vaccine Trial - DoRIS |
| Organisation | University of York |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Member of the team funded by this award is a PI on the grant. |
| Collaborator Contribution | Co-investigator on grant; immunology assays for vaccine trial |
| Impact | None yet |
| Start Year | 2016 |
| Description | HPV vaccine trial - DoRIS |
| Organisation | Catalan Institute of Oncology (ICO) |
| Department | Cancer Epidemiology Research Programme (PREC) |
| Country | Spain |
| Sector | Hospitals |
| PI Contribution | Member of the team is PI on this grant. |
| Collaborator Contribution | co-investigator on grant; HPV assays for vaccine trial |
| Impact | None yet |
| Start Year | 2016 |
| Description | HPV vaccine trial - DoRIS |
| Organisation | Karolinska Institute |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | Member of research team is PI on this grant. |
| Collaborator Contribution | co-investigator on grant; immunology assays for vaccine trial |
| Impact | None yet |
| Start Year | 2016 |
| Description | HPV vaccine trial - DoRIS |
| Organisation | National Institutes of Health (NIH) |
| Department | National Cancer Institute (NCI) |
| Country | United States |
| Sector | Public |
| PI Contribution | Member of team is PI on this grant |
| Collaborator Contribution | co-investigator on grant; immunology assays for vaccine trial |
| Impact | None yet |
| Start Year | 2016 |
| Description | HPV vaccine trial - DoRIS |
| Organisation | National Institutes of Health (NIH) |
| Country | United States |
| Sector | Public |
| PI Contribution | sharing of HPV vaccine immunogenicity data |
| Collaborator Contribution | sharing of HPV vaccine efficacy data for immunobridging |
| Impact | None yet |
| Start Year | 2016 |
| Description | HomeACF |
| Organisation | University of the Witwatersrand |
| Country | South Africa |
| Sector | Academic/University |
| PI Contribution | Trial design and analysis |
| Collaborator Contribution | Trial design and co-ordination |
| Impact | Multi-disciplinary: public health, health economics, statistics |
| Start Year | 2016 |
| Description | IRD TB Programme Evaluation |
| Organisation | IRD Global |
| Country | Pakistan |
| Sector | Charity/Non Profit |
| PI Contribution | Co-design of evaluation of TB control programme through prevalence surveys and will do the analysis |
| Collaborator Contribution | Co-design and running of evaluation |
| Impact | Multi-disciplinary: Epidemiology, public health, statistics |
| Start Year | 2016 |
| Description | IVM Malaysia |
| Organisation | Bayer |
| Department | Bayer CropScience Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Study design and analysis |
| Collaborator Contribution | As previous, plus field and lab work. |
| Impact | Multi-disciplinary: epidemiology, entomology, statistics, public health, social science |
| Start Year | 2017 |
| Description | Ilorin-Gambia-LSHTM group on sickle cell disease |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Unit, The Gambia |
| Country | Gambia |
| Sector | Public |
| PI Contribution | Design and coordination of the randomized trial |
| Collaborator Contribution | Conducted the clinic-based trial |
| Impact | Evidence to support policy change for the management of sickle cell patients in malaria endemic areas. This collaboration is multi-disciplinary involving clinical medicine, epidemioogy, statistics, molecular biology. |
| Start Year | 2010 |
| Description | Ilorin-Gambia-LSHTM group on sickle cell disease |
| Organisation | University of Ilorin Teaching Hospital, Nigeria |
| Country | Nigeria |
| Sector | Academic/University |
| PI Contribution | Design and coordination of the randomized trial |
| Collaborator Contribution | Conducted the clinic-based trial |
| Impact | Evidence to support policy change for the management of sickle cell patients in malaria endemic areas. This collaboration is multi-disciplinary involving clinical medicine, epidemioogy, statistics, molecular biology. |
| Start Year | 2010 |
| Description | Improving the health systems response to chronic diseases in Africa |
| Organisation | MRC/UVRI Uganda Research Unit on AIDS |
| Country | Uganda |
| Sector | Public |
| PI Contribution | Statistical support - analysis, reporting of results. PI and Tanzania PI based at MITU; study co-run by MITU |
| Collaborator Contribution | Study co-run by MRC Uganda |
| Impact | Number of manuscripts phase 1 (surveys): published 8. Phase 2: 2 papers in preparation. 1 book chapter published. Impacted on NCD control practice in Uganda and Tanzania. E.g. Tz introduced position of district NCD coordinators, District Mos allocated funds to purchase of NCD drugs. (These impacts are tangible but direct link to project difficult to prove). |
| Start Year | 2011 |
| Description | Improving the health systems response to chronic diseases in Africa |
| Organisation | Ministry of Health and Social Welfare |
| Country | Tanzania, United Republic of |
| Sector | Public |
| PI Contribution | Statistical support - analysis, reporting of results. PI and Tanzania PI based at MITU; study co-run by MITU |
| Collaborator Contribution | Study co-run by MRC Uganda |
| Impact | Number of manuscripts phase 1 (surveys): published 8. Phase 2: 2 papers in preparation. 1 book chapter published. Impacted on NCD control practice in Uganda and Tanzania. E.g. Tz introduced position of district NCD coordinators, District Mos allocated funds to purchase of NCD drugs. (These impacts are tangible but direct link to project difficult to prove). |
| Start Year | 2011 |
| Description | Improving the health systems response to chronic diseases in Africa |
| Organisation | National Institute for Medical Research, Tanzania |
| Department | Mwanza Intervention Trials Unit (MITU) |
| Country | Tanzania, United Republic of |
| Sector | Public |
| PI Contribution | Statistical support - analysis, reporting of results. PI and Tanzania PI based at MITU; study co-run by MITU |
| Collaborator Contribution | Study co-run by MRC Uganda |
| Impact | Number of manuscripts phase 1 (surveys): published 8. Phase 2: 2 papers in preparation. 1 book chapter published. Impacted on NCD control practice in Uganda and Tanzania. E.g. Tz introduced position of district NCD coordinators, District Mos allocated funds to purchase of NCD drugs. (These impacts are tangible but direct link to project difficult to prove). |
| Start Year | 2011 |
| Description | Infection prevention and control for drug-resistant tuberculosis in South Africa (AHRI) |
| Organisation | Africa Health Research Institute |
| Country | South Africa |
| Sector | Charity/Non Profit |
| PI Contribution | sample size, study design, statistical analysis, sampling |
| Collaborator Contribution | study design, analysis, field activities |
| Impact | Multi-disciplinary: epidemiology, statistics, modelling, social science |
| Start Year | 2017 |
| Description | Leaving no-one behind |
| Organisation | MRC/UVRI Uganda Research Unit on AIDS |
| Country | Uganda |
| Sector | Public |
| PI Contribution | Co-investigator |
| Collaborator Contribution | Study co-ordination and analysis |
| Impact | Discipline: social science |
| Start Year | 2016 |
| Description | Lung disease in HIV infected children |
| Organisation | Biomedical Research and Training Institute (BRTI) |
| Country | Zimbabwe |
| Sector | Charity/Non Profit |
| PI Contribution | Statistical and epidemiological collaboration |
| Collaborator Contribution | Leadership and all aspects of the trial |
| Impact | Trial initiating in 2016. |
| Start Year | 2014 |
| Description | Lung disease in HIV infected children |
| Organisation | University of Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Statistical and epidemiological collaboration |
| Collaborator Contribution | Leadership and all aspects of the trial |
| Impact | Trial initiating in 2016. |
| Start Year | 2014 |
| Description | Lung disease in HIV infected children |
| Organisation | University of Tromso |
| Country | Norway |
| Sector | Academic/University |
| PI Contribution | Statistical and epidemiological collaboration |
| Collaborator Contribution | Leadership and all aspects of the trial |
| Impact | Trial initiating in 2016. |
| Start Year | 2014 |
| Description | MDR-TB infection control |
| Organisation | Queen Margaret University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | co-design of study and analysis |
| Collaborator Contribution | co-design, coordination, ethnographic work, policy review, laboratory work, health economics |
| Impact | Multi-disciplinary: Epidemiology, public health, health economics, modelling, anthropology, statistics |
| Start Year | 2017 |
| Description | MDR-TB infection control |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | co-design of study and analysis |
| Collaborator Contribution | co-design, coordination, ethnographic work, policy review, laboratory work, health economics |
| Impact | Multi-disciplinary: Epidemiology, public health, health economics, modelling, anthropology, statistics |
| Start Year | 2017 |
| Description | MDR-TB infection control |
| Organisation | University of Cape Town |
| Country | South Africa |
| Sector | Academic/University |
| PI Contribution | co-design of study and analysis |
| Collaborator Contribution | co-design, coordination, ethnographic work, policy review, laboratory work, health economics |
| Impact | Multi-disciplinary: Epidemiology, public health, health economics, modelling, anthropology, statistics |
| Start Year | 2017 |
| Description | MDR-TB infection control |
| Organisation | University of KwaZulu-Natal |
| Country | South Africa |
| Sector | Academic/University |
| PI Contribution | co-design of study and analysis |
| Collaborator Contribution | co-design, coordination, ethnographic work, policy review, laboratory work, health economics |
| Impact | Multi-disciplinary: Epidemiology, public health, health economics, modelling, anthropology, statistics |
| Start Year | 2017 |
| Description | MENISCUS |
| Organisation | MRC/UVRI Uganda Research Unit on AIDS |
| Country | Uganda |
| Sector | Public |
| PI Contribution | Leadership, design and analysis |
| Collaborator Contribution | Study co-ordination |
| Impact | Outcome: Funding of JGHT trials development grant Multi-disciplinary: epidemiology, social science |
| Start Year | 2015 |
| Description | MENISCUS2 |
| Organisation | MRC/UVRI Uganda Research Unit on AIDS |
| Country | Uganda |
| Sector | Public |
| PI Contribution | Leadership, design and analysis |
| Collaborator Contribution | Study co-ordination |
| Impact | Multi-disciplinary: epidemiology, social science |
| Start Year | 2017 |
| Description | MTV Shuga Evaluation |
| Organisation | Africa Health Research Institute |
| Country | South Africa |
| Sector | Charity/Non Profit |
| PI Contribution | co-investigator; study design and analysis |
| Collaborator Contribution | Design and running of evaluation |
| Impact | No outputs yet. Disciplines include epidemiology, public health, statistics, qualitative research |
| Start Year | 2017 |
| Description | MTV Shuga Evaluation |
| Organisation | Epicentre |
| Country | United States |
| Sector | Private |
| PI Contribution | co-investigator; study design and analysis |
| Collaborator Contribution | Design and running of evaluation |
| Impact | No outputs yet. Disciplines include epidemiology, public health, statistics, qualitative research |
| Start Year | 2017 |
| Description | MTV Shuga Evaluation |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | co-investigator; study design and analysis |
| Collaborator Contribution | Design and running of evaluation |
| Impact | No outputs yet. Disciplines include epidemiology, public health, statistics, qualitative research |
| Start Year | 2017 |
| Description | Malaria elimination trial |
| Organisation | Aix-Marseille University |
| Country | France |
| Sector | Academic/University |
| PI Contribution | LSHTM are responsible for the co-ordination of the trials. |
| Collaborator Contribution | The University of Marseilles is contributing in terms of statistical spatial analysis, and genotyping to identify parasite strains. |
| Impact | No outputs as yet to report. |
| Start Year | 2013 |
| Description | Management of child malnutrition in India |
| Organisation | Médecins Sans Frontières (MSF) |
| Country | France |
| Sector | Charity/Non Profit |
| PI Contribution | study design & analysis |
| Collaborator Contribution | study design & analysis, field visits |
| Impact | None yet. Multi-disciplinary: clinical trials, epidemiology, public health, statistics |
| Start Year | 2017 |
| Description | Monitoring and Evaluation of implementation of interventions for VL in Africa and Asia |
| Organisation | Drugs for Neglected Diseases initiative (DNDi) |
| Country | Switzerland |
| Sector | Charity/Non Profit |
| PI Contribution | Contributing to design and analysis of surveys |
| Collaborator Contribution | Project management, intellectual input |
| Impact | Multi disciplinary - Epidemiology, public health, statistics |
| Start Year | 2014 |
| Description | Monitoring and Evaluation of implementation of interventions for VL in Africa and Asia |
| Organisation | Mott Macdonald UK Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Contributing to design and analysis of surveys |
| Collaborator Contribution | Project management, intellectual input |
| Impact | Multi disciplinary - Epidemiology, public health, statistics |
| Start Year | 2014 |
| Description | Monitoring and Evaluation of implementation of interventions for VL in Africa and Asia |
| Organisation | Médecins Sans Frontières (MSF) |
| Country | France |
| Sector | Charity/Non Profit |
| PI Contribution | Contributing to design and analysis of surveys |
| Collaborator Contribution | Project management, intellectual input |
| Impact | Multi disciplinary - Epidemiology, public health, statistics |
| Start Year | 2014 |
| Description | Namibia Malaria Elimination Partnership (NAMEP) |
| Organisation | Clinton Health Access Initiative |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | Trial design; funding of vector control component through Wits University. |
| Collaborator Contribution | Funding of trial; logistics; trial management and governance; support to namtional Malaria Control programme |
| Impact | "Trial Protocol; Smith, J. L., Auala, J., Haindongo, E., Uusiku, P., Gosling, R., Kleinschmidt, I., Mumbengegwi, D., Sturrock, H. J. W. (2017). Malaria risk in young male travellers but local transmission persists: a case-control study in low transmission Namibia. Malaria Journal, 16, 70. http://doi.org/10.1186/s12936-017-1719-x" Multi-disciplinary: Epidemiology, Disease Control, Pharmacology, Entomology. Vector Control, Statistics. Modelling, Immunology |
| Start Year | 2015 |
| Description | Namibia Malaria Elimination Partnership (NAMEP) |
| Organisation | National Vector-borne Diseases Control Programme (NVDCP) |
| Country | Namibia |
| Sector | Public |
| PI Contribution | Trial design; funding of vector control component through Wits University. |
| Collaborator Contribution | Funding of trial; logistics; trial management and governance; support to namtional Malaria Control programme |
| Impact | "Trial Protocol; Smith, J. L., Auala, J., Haindongo, E., Uusiku, P., Gosling, R., Kleinschmidt, I., Mumbengegwi, D., Sturrock, H. J. W. (2017). Malaria risk in young male travellers but local transmission persists: a case-control study in low transmission Namibia. Malaria Journal, 16, 70. http://doi.org/10.1186/s12936-017-1719-x" Multi-disciplinary: Epidemiology, Disease Control, Pharmacology, Entomology. Vector Control, Statistics. Modelling, Immunology |
| Start Year | 2015 |
| Description | Namibia Malaria Elimination Partnership (NAMEP) |
| Organisation | University of California, San Francisco |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Trial design; funding of vector control component through Wits University. |
| Collaborator Contribution | Funding of trial; logistics; trial management and governance; support to namtional Malaria Control programme |
| Impact | "Trial Protocol; Smith, J. L., Auala, J., Haindongo, E., Uusiku, P., Gosling, R., Kleinschmidt, I., Mumbengegwi, D., Sturrock, H. J. W. (2017). Malaria risk in young male travellers but local transmission persists: a case-control study in low transmission Namibia. Malaria Journal, 16, 70. http://doi.org/10.1186/s12936-017-1719-x" Multi-disciplinary: Epidemiology, Disease Control, Pharmacology, Entomology. Vector Control, Statistics. Modelling, Immunology |
| Start Year | 2015 |
| Description | Namibia Malaria Elimination Partnership (NAMEP) |
| Organisation | University of Namibia |
| Country | Namibia |
| Sector | Academic/University |
| PI Contribution | Trial design; funding of vector control component through Wits University. |
| Collaborator Contribution | Funding of trial; logistics; trial management and governance; support to namtional Malaria Control programme |
| Impact | "Trial Protocol; Smith, J. L., Auala, J., Haindongo, E., Uusiku, P., Gosling, R., Kleinschmidt, I., Mumbengegwi, D., Sturrock, H. J. W. (2017). Malaria risk in young male travellers but local transmission persists: a case-control study in low transmission Namibia. Malaria Journal, 16, 70. http://doi.org/10.1186/s12936-017-1719-x" Multi-disciplinary: Epidemiology, Disease Control, Pharmacology, Entomology. Vector Control, Statistics. Modelling, Immunology |
| Start Year | 2015 |
| Description | Namibia Malaria Elimination Partnership (NAMEP) |
| Organisation | University of the Witwatersrand |
| Country | South Africa |
| Sector | Academic/University |
| PI Contribution | Trial design; funding of vector control component through Wits University. |
| Collaborator Contribution | Funding of trial; logistics; trial management and governance; support to namtional Malaria Control programme |
| Impact | "Trial Protocol; Smith, J. L., Auala, J., Haindongo, E., Uusiku, P., Gosling, R., Kleinschmidt, I., Mumbengegwi, D., Sturrock, H. J. W. (2017). Malaria risk in young male travellers but local transmission persists: a case-control study in low transmission Namibia. Malaria Journal, 16, 70. http://doi.org/10.1186/s12936-017-1719-x" Multi-disciplinary: Epidemiology, Disease Control, Pharmacology, Entomology. Vector Control, Statistics. Modelling, Immunology |
| Start Year | 2015 |
| Description | New nets project |
| Organisation | Entomological Research Centre of Cotonou (CREC) |
| Country | Benin |
| Sector | Academic/University |
| PI Contribution | sample size, study design, statistical analysis, data management |
| Collaborator Contribution | field activities |
| Impact | Multi-disciplinary: epidemiology, vector control, entomology |
| Start Year | 2018 |
| Description | Newton Household Screening - Aurum (Asibamisane) |
| Organisation | Aurum Institute |
| Country | South Africa |
| Sector | Charity/Non Profit |
| PI Contribution | Study design and analysis |
| Collaborator Contribution | Study design and co-ordination |
| Impact | Multi-disciplinary: public health, health economics, statistics, qualitative |
| Start Year | 2016 |
| Description | OFLOTUB |
| Organisation | Ignace Deen Hospital |
| Country | Guinea |
| Sector | Hospitals |
| PI Contribution | Contributed to trial design, conduct of trial, statistical support, data analysis |
| Collaborator Contribution | Significant intellectual input and exchange of ideas |
| Impact | Results presented at the Union TB conference in Paris, 2013. Paper published on trial design (Trials, 2012) and main trial results (NEJM, 2014). |
| Description | OFLOTUB |
| Organisation | Institute of Development Research (IRD) |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Contributed to trial design, conduct of trial, statistical support, data analysis |
| Collaborator Contribution | Significant intellectual input and exchange of ideas |
| Impact | Results presented at the Union TB conference in Paris, 2013. Paper published on trial design (Trials, 2012) and main trial results (NEJM, 2014). |
| Description | OFLOTUB |
| Organisation | Institute of Tropical Medicine Antwerp |
| Country | Belgium |
| Sector | Academic/University |
| PI Contribution | Contributed to trial design, conduct of trial, statistical support, data analysis |
| Collaborator Contribution | Significant intellectual input and exchange of ideas |
| Impact | Results presented at the Union TB conference in Paris, 2013. Paper published on trial design (Trials, 2012) and main trial results (NEJM, 2014). |
| Description | OFLOTUB |
| Organisation | Medical Research Council of South Africa (MRC) |
| Country | South Africa |
| Sector | Public |
| PI Contribution | Contributed to trial design, conduct of trial, statistical support, data analysis |
| Collaborator Contribution | Significant intellectual input and exchange of ideas |
| Impact | Results presented at the Union TB conference in Paris, 2013. Paper published on trial design (Trials, 2012) and main trial results (NEJM, 2014). |
| Description | OFLOTUB |
| Organisation | National Hospital of Pneumo-Phtisiology |
| Country | Benin |
| Sector | Hospitals |
| PI Contribution | Contributed to trial design, conduct of trial, statistical support, data analysis |
| Collaborator Contribution | Significant intellectual input and exchange of ideas |
| Impact | Results presented at the Union TB conference in Paris, 2013. Paper published on trial design (Trials, 2012) and main trial results (NEJM, 2014). |
| Description | OFLOTUB |
| Organisation | Programme National de Lutte contre la Tuberculose |
| Country | Senegal |
| Sector | Public |
| PI Contribution | Contributed to trial design, conduct of trial, statistical support, data analysis |
| Collaborator Contribution | Significant intellectual input and exchange of ideas |
| Impact | Results presented at the Union TB conference in Paris, 2013. Paper published on trial design (Trials, 2012) and main trial results (NEJM, 2014). |
| Description | OFLOTUB |
| Organisation | University Hospitals in Paris |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Contributed to trial design, conduct of trial, statistical support, data analysis |
| Collaborator Contribution | Significant intellectual input and exchange of ideas |
| Impact | Results presented at the Union TB conference in Paris, 2013. Paper published on trial design (Trials, 2012) and main trial results (NEJM, 2014). |
| Description | OFLOTUB |
| Organisation | World Health Organization (WHO) |
| Department | Tropical Disease Research (TDR) |
| Country | Switzerland |
| Sector | Public |
| PI Contribution | Contributed to trial design, conduct of trial, statistical support, data analysis |
| Collaborator Contribution | Significant intellectual input and exchange of ideas |
| Impact | Results presented at the Union TB conference in Paris, 2013. Paper published on trial design (Trials, 2012) and main trial results (NEJM, 2014). |
| Description | Observational study: Bioko Island Malaria Control Projects, Phase I |
| Organisation | Liverpool School of Tropical Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Design of monitoring and surveillance systems, annual survey design and analsysis, impact evaluation of multiple interventions |
| Collaborator Contribution | Multicountry analysis of combined interventions; evaluation of surveillance methods and impact assessment; significant intellectual input and mutual exchange of ideas |
| Impact | Phase I found a major reduction in child mortality following an intensification of malaria control initiatives over a 4 year period on Bioko Island, Equatorial Guinea. Results published in Kleinschmidt et al. American Journal of Tropical Medicine & Hygiene, 2009; 80:882-888 |
| Description | Observational study: Bioko Island Malaria Control Projects, Phase I |
| Organisation | Medical Care Development International (MCDI) |
| Country | United States |
| Sector | Private |
| PI Contribution | Design of monitoring and surveillance systems, annual survey design and analsysis, impact evaluation of multiple interventions |
| Collaborator Contribution | Multicountry analysis of combined interventions; evaluation of surveillance methods and impact assessment; significant intellectual input and mutual exchange of ideas |
| Impact | Phase I found a major reduction in child mortality following an intensification of malaria control initiatives over a 4 year period on Bioko Island, Equatorial Guinea. Results published in Kleinschmidt et al. American Journal of Tropical Medicine & Hygiene, 2009; 80:882-888 |
| Description | Observational study: Bioko Island Malaria Control Projects, Phase I |
| Organisation | University of Texas |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Design of monitoring and surveillance systems, annual survey design and analsysis, impact evaluation of multiple interventions |
| Collaborator Contribution | Multicountry analysis of combined interventions; evaluation of surveillance methods and impact assessment; significant intellectual input and mutual exchange of ideas |
| Impact | Phase I found a major reduction in child mortality following an intensification of malaria control initiatives over a 4 year period on Bioko Island, Equatorial Guinea. Results published in Kleinschmidt et al. American Journal of Tropical Medicine & Hygiene, 2009; 80:882-888 |
| Description | Observational study: Bioko Island Malaria Control Projects, Phase I |
| Organisation | Yale University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Design of monitoring and surveillance systems, annual survey design and analsysis, impact evaluation of multiple interventions |
| Collaborator Contribution | Multicountry analysis of combined interventions; evaluation of surveillance methods and impact assessment; significant intellectual input and mutual exchange of ideas |
| Impact | Phase I found a major reduction in child mortality following an intensification of malaria control initiatives over a 4 year period on Bioko Island, Equatorial Guinea. Results published in Kleinschmidt et al. American Journal of Tropical Medicine & Hygiene, 2009; 80:882-888 |
| Description | PANGEA |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We will be contributing specimens (from PopART trial) to an international collaboration using sequencing and phylogenetic analysis to better understand the transmission dynamics of HIV. |
| Collaborator Contribution | Co-ordination; organisation of sequencing pipeline; workshops; financial management. |
| Impact | Multi-disciplinary: Epidemiology, public health |
| Start Year | 2013 |
| Description | POPVAC trials |
| Organisation | Medical Research Council (MRC) |
| Department | MRC/UVRI and LSHTM Research Unit Uganda |
| Country | Uganda |
| Sector | Academic/University |
| PI Contribution | study design and set up, study anlaysis |
| Collaborator Contribution | field activities, trial management, study design |
| Impact | Multi-disciplinary: statistics, clinical trials, immunology, public health |
| Start Year | 2018 |
| Description | PREMIUM |
| Organisation | Sangath |
| Country | India |
| Sector | Charity/Non Profit |
| PI Contribution | Trial design and analysis |
| Collaborator Contribution | Trial design and co-ordination |
| Impact | 3 papers published, detail in publications section of submission Multi-disciplinary: epidemiology, public health |
| Start Year | 2010 |
| Description | PRIDE |
| Organisation | Harvard University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Statistical support |
| Collaborator Contribution | Study design, implementation and evaluation |
| Impact | one publication, main results paper submitted. Multidisciplinary: epidemiology, psychiatry |
| Start Year | 2017 |
| Description | PROSPECT study |
| Organisation | University of Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | statistical advice |
| Collaborator Contribution | study design; coordination; field activities; analysis |
| Impact | None yet. Multidisciplinary: epidemiology, public health, statistics, clinical trials |
| Start Year | 2017 |
| Description | PROSPECT study |
| Organisation | Wellcome Trust |
| Department | Malawi-Liverpool Wellcome Trust Clinical Research Programme |
| Country | Malawi |
| Sector | Academic/University |
| PI Contribution | statistical advice |
| Collaborator Contribution | study design; coordination; field activities; analysis |
| Impact | None yet. Multidisciplinary: epidemiology, public health, statistics, clinical trials |
| Start Year | 2017 |
| Description | Paediatric praziquantel |
| Organisation | Brown University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | study design; statistical advice; analysis |
| Collaborator Contribution | study design; coordination; field activities |
| Impact | None yet. Multidisciplinary: epidemiology, public health, statistics, clinical trials |
| Start Year | 2017 |
| Description | Paediatric praziquantel |
| Organisation | Medical Research Council (MRC) |
| Department | MRC/UVRI and LSHTM Research Unit Uganda |
| Country | Uganda |
| Sector | Academic/University |
| PI Contribution | study design; statistical advice; analysis |
| Collaborator Contribution | study design; coordination; field activities |
| Impact | None yet. Multidisciplinary: epidemiology, public health, statistics, clinical trials |
| Start Year | 2017 |
| Description | Paediatric praziquantel |
| Organisation | Ministry of Health, Uganda |
| Country | Uganda |
| Sector | Public |
| PI Contribution | study design; statistical advice; analysis |
| Collaborator Contribution | study design; coordination; field activities |
| Impact | None yet. Multidisciplinary: epidemiology, public health, statistics, clinical trials |
| Start Year | 2017 |
| Description | Pangea2 |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We will be contributing specimens (from PopART trial) to an international collaboration using sequencing and phylogenetic analysis to better understand the transmission dynamics of HIV. |
| Collaborator Contribution | Co-ordination; organisation of sequencing pipeline; workshops; financial management. |
| Impact | None yet. Multidisciplinary: Epidemiology, public health, molecular epidemiology,virology |
| Start Year | 2018 |
| Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
| Organisation | Bill and Melinda Gates Foundation |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | Statistical advice, study design |
| Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
| Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
| Start Year | 2008 |
| Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
| Organisation | Centers for Disease Control and Prevention (CDC) |
| Country | United States |
| Sector | Public |
| PI Contribution | Statistical advice, study design |
| Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
| Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
| Start Year | 2008 |
| Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
| Organisation | Georgia Institute of Technology |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Statistical advice, study design |
| Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
| Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
| Start Year | 2008 |
| Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
| Organisation | Ghana Health Service |
| Country | Ghana |
| Sector | Public |
| PI Contribution | Statistical advice, study design |
| Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
| Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
| Start Year | 2008 |
| Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
| Organisation | Health Protection and Research Organisation (HPRO) |
| Country | Afghanistan |
| Sector | Public |
| PI Contribution | Statistical advice, study design |
| Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
| Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
| Start Year | 2008 |
| Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
| Organisation | HealthNet |
| Country | Afghanistan |
| Sector | Charity/Non Profit |
| PI Contribution | Statistical advice, study design |
| Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
| Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
| Start Year | 2008 |
| Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
| Organisation | Ifakara Health Institute |
| Country | Tanzania, United Republic of |
| Sector | Charity/Non Profit |
| PI Contribution | Statistical advice, study design |
| Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
| Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
| Start Year | 2008 |
| Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
| Organisation | Karolinska Institute |
| Department | Department of Public Health Sciences |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | Statistical advice, study design |
| Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
| Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
| Start Year | 2008 |
| Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
| Organisation | Kilimanjaro Christian Medical Centre (KCMS) |
| Country | Tanzania, United Republic of |
| Sector | Hospitals |
| PI Contribution | Statistical advice, study design |
| Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
| Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
| Start Year | 2008 |
| Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
| Organisation | Kintampo Health Research Centre |
| Country | Ghana |
| Sector | Hospitals |
| PI Contribution | Statistical advice, study design |
| Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
| Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
| Start Year | 2008 |
| Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
| Organisation | Liverpool School of Tropical Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Statistical advice, study design |
| Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
| Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
| Start Year | 2008 |
| Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
| Organisation | Makerere University |
| Country | Uganda |
| Sector | Academic/University |
| PI Contribution | Statistical advice, study design |
| Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
| Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
| Start Year | 2008 |
| Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
| Organisation | Merlin, Afghanistan |
| Country | Afghanistan |
| Sector | Private |
| PI Contribution | Statistical advice, study design |
| Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
| Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
| Start Year | 2008 |
| Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
| Organisation | Ministry of Health, Uganda |
| Country | Uganda |
| Sector | Public |
| PI Contribution | Statistical advice, study design |
| Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
| Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
| Start Year | 2008 |
| Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
| Organisation | National Institute for Medical Research, Tanzania |
| Country | Tanzania, United Republic of |
| Sector | Public |
| PI Contribution | Statistical advice, study design |
| Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
| Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
| Start Year | 2008 |
| Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
| Organisation | National Malaria Control Programme, Cambodia |
| Country | Cambodia |
| Sector | Public |
| PI Contribution | Statistical advice, study design |
| Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
| Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
| Start Year | 2008 |
| Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
| Organisation | National Malaria Control Programme, Tanzania |
| Country | Tanzania, United Republic of |
| Sector | Public |
| PI Contribution | Statistical advice, study design |
| Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
| Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
| Start Year | 2008 |
| Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
| Organisation | University of California, San Francisco |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Statistical advice, study design |
| Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
| Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
| Start Year | 2008 |
| Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
| Organisation | University of Cape Town |
| Country | South Africa |
| Sector | Academic/University |
| PI Contribution | Statistical advice, study design |
| Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
| Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
| Start Year | 2008 |
| Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Statistical advice, study design |
| Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
| Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
| Start Year | 2008 |
| Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
| Organisation | University of Malawi |
| Country | Malawi |
| Sector | Academic/University |
| PI Contribution | Statistical advice, study design |
| Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
| Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
| Start Year | 2008 |
| Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
| Organisation | University of Nigeria |
| Country | Nigeria |
| Sector | Academic/University |
| PI Contribution | Statistical advice, study design |
| Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
| Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
| Start Year | 2008 |
| Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
| Organisation | University of Yaoundé |
| Country | Cameroon |
| Sector | Academic/University |
| PI Contribution | Statistical advice, study design |
| Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
| Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
| Start Year | 2008 |
| Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
| Organisation | Zanzibar Malaria Control Program |
| Country | Tanzania, United Republic of |
| Sector | Academic/University |
| PI Contribution | Statistical advice, study design |
| Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
| Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
| Start Year | 2008 |
| Description | Partnership: TB preventive therapy and case finding with the consortium to respond effectively to the AIDS and TB epidemics (CREATE) |
| Organisation | Johns Hopkins University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | TEG has contributed to the design of two clinical trials: Zamstar and Thibela TB. We have also developed the trial protocols and provided statistical support and led on data analysis. |
| Collaborator Contribution | Collaborative involvement in statistical analysis of cluster randomised trials and data management of large field-based studies |
| Impact | Both trials have been completed successfully. Zamstar results presented at Union World Conference on Lung Health (2011) and CROI (2012). Thibela results presented at CROI (2012) and the South African TB Conference (2012). Trial results have been published - Zamstar in Lancet (2013) and Thibela in NEJM (2014). Several publications are in progress and we intend to apply the learning from both trials to future trial design. |
| Start Year | 2006 |
| Description | PopART modelling and phylogenetics |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | study design, coordination, publications |
| Collaborator Contribution | mathematical modelling, phylogenetics/sequencing |
| Impact | Poster at CROI conference Multi-disciplinary: modelling, sequencing, epidemiology Information sheet on their Best Practices Compendium of evidence-based interventions for HIV prevention |
| Start Year | 2018 |
| Description | PrEP demonstration projectc |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | co-design of study and analysis; coordination of project at the Africa Centre site |
| Collaborator Contribution | co-design, coordination of project at 2 other sites (Cape Town & Soweto) |
| Impact | Multi-disciplinary: epidemiology, public health, health economics, social science, statistics |
| Start Year | 2016 |
| Description | PrEP demonstration projectc |
| Organisation | University of Cape Town |
| Department | Desmond Tutu HIV Centre |
| Country | South Africa |
| Sector | Academic/University |
| PI Contribution | co-design of study and analysis; coordination of project at the Africa Centre site |
| Collaborator Contribution | co-design, coordination of project at 2 other sites (Cape Town & Soweto) |
| Impact | Multi-disciplinary: epidemiology, public health, health economics, social science, statistics |
| Start Year | 2016 |
| Description | PrEP demonstration projectc |
| Organisation | University of Cape Town |
| Country | South Africa |
| Sector | Academic/University |
| PI Contribution | co-design of study and analysis; coordination of project at the Africa Centre site |
| Collaborator Contribution | co-design, coordination of project at 2 other sites (Cape Town & Soweto) |
| Impact | Multi-disciplinary: epidemiology, public health, health economics, social science, statistics |
| Start Year | 2016 |
| Description | PrEP demonstration projectc |
| Organisation | University of the Witwatersrand |
| Department | Perinatal HIV Research Unit |
| Country | South Africa |
| Sector | Academic/University |
| PI Contribution | co-design of study and analysis; coordination of project at the Africa Centre site |
| Collaborator Contribution | co-design, coordination of project at 2 other sites (Cape Town & Soweto) |
| Impact | Multi-disciplinary: epidemiology, public health, health economics, social science, statistics |
| Start Year | 2016 |
| Description | Preparing for clinical trials of interventions to improve the reproductive health of adolescent girls in sub-Saharan Africa |
| Organisation | Institute of Tropical Medicine Antwerp |
| Country | Belgium |
| Sector | Academic/University |
| PI Contribution | study design, statistical analysis, co-investigators |
| Collaborator Contribution | priniciple investiagor; sample testing; significant intellectual input and exchange of ideas |
| Impact | Results pending; analyses currently underway |
| Start Year | 2012 |
| Description | Preparing for clinical trials of interventions to improve the reproductive health of adolescent girls in sub-Saharan Africa |
| Organisation | National Institute for Medical Research, Tanzania |
| Department | Mwanza Intervention Trials Unit (MITU) |
| Country | Tanzania, United Republic of |
| Sector | Public |
| PI Contribution | study design, statistical analysis, co-investigators |
| Collaborator Contribution | priniciple investiagor; sample testing; significant intellectual input and exchange of ideas |
| Impact | Results pending; analyses currently underway |
| Start Year | 2012 |
| Description | Preparing for clinical trials of interventions to improve the reproductive health of adolescent girls in sub-Saharan Africa |
| Organisation | National Institute for Medical Research, Tanzania |
| Department | NIMR Mbeya Research Centre |
| Country | Tanzania, United Republic of |
| Sector | Academic/University |
| PI Contribution | study design, statistical analysis, co-investigators |
| Collaborator Contribution | priniciple investiagor; sample testing; significant intellectual input and exchange of ideas |
| Impact | Results pending; analyses currently underway |
| Start Year | 2012 |
| Description | REEHAD study, The Role of Environmental Enteropathy on HIV-Associated Diabetes |
| Organisation | National Institute for Medical Research, Tanzania |
| Country | Tanzania, United Republic of |
| Sector | Public |
| PI Contribution | sample size, study design, statistical analysis, data management |
| Collaborator Contribution | field activities |
| Impact | Multi-disciplinary: Nutrition, epidemiology, gastroenterology |
| Start Year | 2019 |
| Description | RIFASHORT trial |
| Organisation | St George's University of London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | sample size, study design, statistical analysis, data management |
| Collaborator Contribution | trial design and coordination, field activities |
| Impact | Multi-disciplinary: epidemiology, public health, statistics, clinical trials |
| Start Year | 2016 |
| Description | RKSK evaluation |
| Organisation | Public Health Foundation of India |
| Country | India |
| Sector | Public |
| PI Contribution | Co-design of evaluation of governmental adolescent health programme ("RKSK") and will do the analysis |
| Collaborator Contribution | Co-design and running of evaluation |
| Impact | Outcome: successful grant application to the MRC Multi-disciplinary: Epidemiology, public health, statistics |
| Start Year | 2016 |
| Description | RTS,S-SMC trial |
| Organisation | National Center for Scientific and Technological Research (CNRST) |
| Department | Institute of Research in Health Sciences |
| Country | Burkina Faso |
| Sector | Public |
| PI Contribution | Study design, analysis |
| Collaborator Contribution | Clinical, field, lab studies |
| Impact | None yet, (main trial paper later in 2020) Multidisciplinary: epidemiology, statistics, clinical trials |
| Start Year | 2017 |
| Description | RTS,S-SMC trial |
| Organisation | University of Bamako |
| Department | Malaria Research and Training Centre (MRTC) Bamako |
| Country | Mali |
| Sector | Academic/University |
| PI Contribution | Study design, analysis |
| Collaborator Contribution | Clinical, field, lab studies |
| Impact | None yet, (main trial paper later in 2020) Multidisciplinary: epidemiology, statistics, clinical trials |
| Start Year | 2017 |
| Description | Reporting of stepped wedge trials |
| Organisation | Monash University |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | study design and advice |
| Collaborator Contribution | study design, coordination, advice, analysis |
| Impact | Two publications. Multidisciplinary: statistics, clinical trials, ethics |
| Start Year | 2017 |
| Description | Reporting of stepped wedge trials |
| Organisation | Queen Mary University of London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | study design and advice |
| Collaborator Contribution | study design, coordination, advice, analysis |
| Impact | Two publications. Multidisciplinary: statistics, clinical trials, ethics |
| Start Year | 2017 |
| Description | Reporting of stepped wedge trials |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | study design and advice |
| Collaborator Contribution | study design, coordination, advice, analysis |
| Impact | Two publications. Multidisciplinary: statistics, clinical trials, ethics |
| Start Year | 2017 |
| Description | Reporting of stepped wedge trials |
| Organisation | University of Birmingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | study design and advice |
| Collaborator Contribution | study design, coordination, advice, analysis |
| Impact | Two publications. Multidisciplinary: statistics, clinical trials, ethics |
| Start Year | 2017 |
| Description | Reporting of stepped wedge trials |
| Organisation | University of Ottawa |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | study design and advice |
| Collaborator Contribution | study design, coordination, advice, analysis |
| Impact | Two publications. Multidisciplinary: statistics, clinical trials, ethics |
| Start Year | 2017 |
| Description | Reporting of stepped wedge trials |
| Organisation | University of Sheffield |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | study design and advice |
| Collaborator Contribution | study design, coordination, advice, analysis |
| Impact | Two publications. Multidisciplinary: statistics, clinical trials, ethics |
| Start Year | 2017 |
| Description | Reporting of stepped wedge trials |
| Organisation | Western University |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | study design and advice |
| Collaborator Contribution | study design, coordination, advice, analysis |
| Impact | Two publications. Multidisciplinary: statistics, clinical trials, ethics |
| Start Year | 2017 |
| Description | RifT Study |
| Organisation | Makerere University |
| Department | Infectious Diseases Institute |
| Country | Uganda |
| Sector | Academic/University |
| PI Contribution | Sample size and statistical advice |
| Collaborator Contribution | study design and setup, coordination, protocol writing, ethics applications |
| Impact | No outputs yet. Disciplines include clinical trials, epidemiology, public health, statistics |
| Start Year | 2017 |
| Description | RifT Study |
| Organisation | Radboud University Nijmegen |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Sample size and statistical advice |
| Collaborator Contribution | study design and setup, coordination, protocol writing, ethics applications |
| Impact | No outputs yet. Disciplines include clinical trials, epidemiology, public health, statistics |
| Start Year | 2017 |
| Description | SEHER |
| Organisation | Sangath |
| Country | India |
| Sector | Charity/Non Profit |
| PI Contribution | Trial design and analysis |
| Collaborator Contribution | Trial design and co-ordination |
| Impact | Multi-disciplinary: epidemiology, public health |
| Start Year | 2013 |
| Description | STAMP |
| Organisation | Harvard University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Chief-Investigator, Study design and analysis |
| Collaborator Contribution | Study design, co-ordination, economic modelling, trial recruitment |
| Impact | PMID: 27007773; 27659507 ; 27638038; 26266773; 31781758; 30951533; 30683239; 30032978 Multi-disciplinary: public health, health economics, statistics |
| Start Year | 2015 |
| Description | STAMP |
| Organisation | University of Cape Town |
| Country | South Africa |
| Sector | Academic/University |
| PI Contribution | Chief-Investigator, Study design and analysis |
| Collaborator Contribution | Study design, co-ordination, economic modelling, trial recruitment |
| Impact | PMID: 27007773; 27659507 ; 27638038; 26266773; 31781758; 30951533; 30683239; 30032978 Multi-disciplinary: public health, health economics, statistics |
| Start Year | 2015 |
| Description | STAMP |
| Organisation | Wellcome Trust |
| Department | Malawi-Liverpool Wellcome Trust Clinical Research Programme |
| Country | Malawi |
| Sector | Academic/University |
| PI Contribution | Chief-Investigator, Study design and analysis |
| Collaborator Contribution | Study design, co-ordination, economic modelling, trial recruitment |
| Impact | PMID: 27007773; 27659507 ; 27638038; 26266773; 31781758; 30951533; 30683239; 30032978 Multi-disciplinary: public health, health economics, statistics |
| Start Year | 2015 |
| Description | STAR Malawi - secondary distribution of HIVST in ANC |
| Organisation | Wellcome Trust |
| Department | Malawi-Liverpool Wellcome Trust Clinical Research Programme |
| Country | Malawi |
| Sector | Academic/University |
| PI Contribution | Study design and statistical support |
| Collaborator Contribution | Study co-ordination |
| Impact | Multi-disciplinary: Epidemiology, economics, qualitative (most of these outputs are across more than one country) doi: 10.1136/bmjopen-2019-033435; 10.1002/jia2.25255; 10.1002/jia2.25238; 10.1097/QAD.0000000000001918; 10.1186/s12889-018-6120-3. |
| Start Year | 2018 |
| Description | STAR Zambia - Cohort study of secondary distribution and case studies of distribution models |
| Organisation | University of Zambia |
| Department | Zambart |
| Country | Zambia |
| Sector | Academic/University |
| PI Contribution | Study design and statistical support |
| Collaborator Contribution | Study coordination |
| Impact | Multi-disciplinary: Epidemiology, economics, qualitative |
| Start Year | 2018 |
| Description | STAR Zimbabwe |
| Organisation | Centre for Sexual Health and HIV AIDS Research Zimbabwe (CeSHHAR Zimbabwe) |
| Country | Zimbabwe |
| Sector | Charity/Non Profit |
| PI Contribution | Study design and statistical support |
| Collaborator Contribution | Study coordination |
| Impact | Multi-disciplinary: Epidemiology, economics, qualitative |
| Start Year | 2018 |
| Description | STIMA |
| Organisation | Centers for Disease Control and Prevention (CDC) |
| Country | United States |
| Sector | Public |
| PI Contribution | Protocol development and review of analysis and paper |
| Collaborator Contribution | FHI was leading the project and carried out the analysis |
| Impact | 1 paper. |
| Start Year | 2014 |
| Description | STIMA |
| Organisation | Family Health International |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | Protocol development and review of analysis and paper |
| Collaborator Contribution | FHI was leading the project and carried out the analysis |
| Impact | 1 paper. |
| Start Year | 2014 |
| Description | STIMA |
| Organisation | World Health Organization (WHO) |
| Country | Global |
| Sector | Public |
| PI Contribution | Protocol development and review of analysis and paper |
| Collaborator Contribution | FHI was leading the project and carried out the analysis |
| Impact | 1 paper. |
| Start Year | 2014 |
| Description | Scrub typhus India |
| Organisation | Christian Medical College, Vellore |
| Country | India |
| Sector | Academic/University |
| PI Contribution | Study design and analysis |
| Collaborator Contribution | As previous, plus field and lab work. |
| Impact | Multi-disciplinary: epidemiology, clinical science, entomology, statistics, diagnostic assays. |
| Start Year | 2018 |
| Description | Seasonal Malaria Chemoprevention working group |
| Organisation | Roll Back Malaria |
| Country | Switzerland |
| Sector | Charity/Non Profit |
| PI Contribution | Chairing monitoring and evaluation subcommittee. |
| Collaborator Contribution | Members of the monitoring and evaluation subcommittee. |
| Impact | Regional meetings of malaria control programme managers in west Africa |
| Start Year | 2013 |
| Description | Seasonal Malaria Chemoprevention working group |
| Organisation | World Health Organization (WHO) |
| Country | Global |
| Sector | Public |
| PI Contribution | Chairing monitoring and evaluation subcommittee. |
| Collaborator Contribution | Members of the monitoring and evaluation subcommittee. |
| Impact | Regional meetings of malaria control programme managers in west Africa |
| Start Year | 2013 |
| Description | Seasonal Malaria Chemoprevention working group |
| Organisation | Worldwide Antimalarial Resistance Network |
| Country | Global |
| Sector | Charity/Non Profit |
| PI Contribution | Chairing monitoring and evaluation subcommittee. |
| Collaborator Contribution | Members of the monitoring and evaluation subcommittee. |
| Impact | Regional meetings of malaria control programme managers in west Africa |
| Start Year | 2013 |
| Description | Secondment to Nagasaki University |
| Organisation | Nagasaki University |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | Secondment to Nagasaki University (50%) to support research including TB & NCDs in the Philippines, epidemics, malaria. study design & analysis |
| Collaborator Contribution | study design & analysis, field visits |
| Impact | two papers submitted, two in preparation Multi-disciplinary: epidemiology, public health, statistics |
| Start Year | 2018 |
| Description | Severe corneal infections |
| Organisation | Kilimanjaro Christian Medical Centre (KCMS) |
| Country | Tanzania, United Republic of |
| Sector | Hospitals |
| PI Contribution | sample size, study design, statistical analysis, data management |
| Collaborator Contribution | Study coordination |
| Impact | Multidisciplinary: epidemiology, public health, statistics |
| Start Year | 2018 |
| Description | Severe corneal infections |
| Organisation | Mbarara National Referral Hospital |
| Country | Uganda |
| Sector | Hospitals |
| PI Contribution | sample size, study design, statistical analysis, data management |
| Collaborator Contribution | Study coordination |
| Impact | Multidisciplinary: epidemiology, public health, statistics |
| Start Year | 2018 |
| Description | Severe corneal infections |
| Organisation | Sagarmatha Choudhary Eye Hospital |
| Country | Nepal |
| Sector | Hospitals |
| PI Contribution | sample size, study design, statistical analysis, data management |
| Collaborator Contribution | Study coordination |
| Impact | Multidisciplinary: epidemiology, public health, statistics |
| Start Year | 2018 |
| Description | Spatial intelligence system for precision larviciding |
| Organisation | Aberystwyth University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | sample size, study design, statistical analysis, data management |
| Collaborator Contribution | trial design and coordination, field activities |
| Impact | Multi-disciplinary: epidemiology, vector control, geography, spatial |
| Start Year | 2018 |
| Description | Statistical support: IPT for the prevention of malaria and related complications in patients with sickle-cell disease in Nigeria |
| Organisation | University of Ilorin Teaching Hospital, Nigeria |
| Country | Nigeria |
| Sector | Academic/University |
| PI Contribution | Statistical support- analysis and reporting of results |
| Collaborator Contribution | Study conducted in Nigeria |
| Impact | Manuscript currently being prepared. |
| Start Year | 2013 |
| Description | Statistical support: MRC The Gambia |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Unit, The Gambia |
| Country | Gambia |
| Sector | Public |
| PI Contribution | Research support |
| Collaborator Contribution | Increased research output |
| Impact | Large number of collaborative research papers and impact on policy. Secured collaborative research funding. |
| Description | Statistical support: MRC Uganda |
| Organisation | MRC/UVRI Uganda Research Unit on AIDS |
| Country | Uganda |
| Sector | Public |
| PI Contribution | Study design, data analysis, writing and publishing papers, PhD supervision, writing grant proposals, support for quinquennial review proposal |
| Collaborator Contribution | Mutually reinforcing collaboration involving exchange of ideas |
| Impact | Collaborative studies and research papers; ; successful outcome of MRC quinquennial review |
| Description | Statistical support: Mwanza MITU/NIMR |
| Organisation | National Institute for Medical Research, Tanzania |
| Department | Mwanza Intervention Trials Unit (MITU) |
| Country | Tanzania, United Republic of |
| Sector | Public |
| PI Contribution | Epidemiological and statistical input to field studies; design of new studies and preparation of funding applications; capacity building |
| Collaborator Contribution | Collaborative involvement in and field sites for studies of the epidemiology and control of HIV and related infections |
| Impact | HIV microbicide and vaccine feasibility studies, and studies of HPV vaccination and epidemiology successfully completed. Studies of chronic diseases and structural interventions to reduce gender violence ongoing |
| Start Year | 2006 |
| Description | Statistical support: The relationship between anaemia and pubertal growth spurt in Tanzanian sickle cell patients |
| Organisation | Muhimbili Wellcome Programme |
| Country | Tanzania, United Republic of |
| Sector | Charity/Non Profit |
| PI Contribution | Statistical support- analysis and data management |
| Collaborator Contribution | Study conducted in Tanzania |
| Impact | Research instigated. |
| Start Year | 2013 |
| Description | Statistical support: Wellcome Trust Bloomsbury Centre Fellows |
| Organisation | Wellcome Trust |
| Department | Wellcome Trust Bloomsbury Centre |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Epidemiological and statistical support for Wellcome Trust fellows |
| Collaborator Contribution | Collaborative involvement in field research carried out by Wellcome Trust fellows |
| Impact | Successful completion of wide range of field studies including publications in peer-review journals |
| Description | Statistical support: the impact of maternal infection with M. Tuberculosis on the infant response to BCG immunisation |
| Organisation | MRC/UVRI Uganda Research Unit on AIDS |
| Country | Uganda |
| Sector | Public |
| PI Contribution | Statistical design and analysis of the study |
| Collaborator Contribution | Design of the study, obtaining funding, co-ordinating the study |
| Impact | No outputs as yet. |
| Start Year | 2013 |
| Description | Stepped wedge trial analysis |
| Organisation | Monash University |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Project leaders, design of simulation study, conduct analysis, writing paper |
| Collaborator Contribution | Design of simulation study, expertise in methods, contributing to paper writing |
| Impact | Oral presentation at the International Conference on Stepped Wedge Trial Design, UK, and at the Meeting for Current Developments in Cluster Randomised Trials and Stepped Wedge Designs, UK. Multi-disciplinary: Statistics, Clinical Trials |
| Start Year | 2018 |
| Description | Stepped wedge trial analysis |
| Organisation | University of Birmingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Project leaders, design of simulation study, conduct analysis, writing paper |
| Collaborator Contribution | Design of simulation study, expertise in methods, contributing to paper writing |
| Impact | Oral presentation at the International Conference on Stepped Wedge Trial Design, UK, and at the Meeting for Current Developments in Cluster Randomised Trials and Stepped Wedge Designs, UK. Multi-disciplinary: Statistics, Clinical Trials |
| Start Year | 2018 |
| Description | Stronger SAFE |
| Organisation | Fred Hollows Foundation |
| Country | Australia |
| Sector | Charity/Non Profit |
| PI Contribution | Study design, statistical advice, analysis |
| Collaborator Contribution | study design; coordination; field work; economic modelling; |
| Impact | No outputs yet. Disciplines include epidemiology, public health, statistics, qualitative research |
| Start Year | 2017 |
| Description | Stronger SAFE |
| Organisation | The Wellcome Trust Sanger Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Study design, statistical advice, analysis |
| Collaborator Contribution | study design; coordination; field work; economic modelling; |
| Impact | No outputs yet. Disciplines include epidemiology, public health, statistics, qualitative research |
| Start Year | 2017 |
| Description | Support for design and analysis of clinical research projects & support for data management and reporting of clinical projects |
| Organisation | Drugs for Neglected Diseases initiative (DNDi) |
| Country | Switzerland |
| Sector | Charity/Non Profit |
| PI Contribution | We provide ongoing statistical and epidemiological support for trials of the treatment of visceral leishmaniasis in multi-centre studies in East Africa, coordinated from a data centre in KEMRI, Nairobi. The grant also supports participation in a Data Safety and Monitoring Committee for similar trials, also conducted under the sponsorship of DNDi in India and Bangladesh. |
| Collaborator Contribution | Implementation of trial, coordination and management. |
| Impact | Paper led to informing national treatment policy in Sudan, Kenya, Uganda and Ethiopia. (Sodium stibogluconate plus paramomycin incorporated as the new standard treatment regimin for patients with VL) |
| Description | TB & NCDs in the Philippines |
| Organisation | Nagasaki University |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | study design & analysis |
| Collaborator Contribution | study design & analysis, field visits |
| Impact | none yet. Multidisciplinary: epidemiology, public health, statistics |
| Start Year | 2016 |
| Description | TB China: CRT of medication monitor in TB case management |
| Organisation | Bill and Melinda Gates Foundation |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | Contributed to trial design, statistical support, data analysis |
| Collaborator Contribution | Expertise in TB epidemiology, field studies |
| Impact | Design of current cluster-randomized trial including economic costing of intervention; ongoing analysis of previous trial. Disciplines involved - Epidemiology, public health, health economics |
| Start Year | 2010 |
| Description | TB China: CRT of medication monitor in TB case management |
| Organisation | Chinese Center for Disease Control and Prevention (China CDC) |
| Country | China |
| Sector | Public |
| PI Contribution | Contributed to trial design, statistical support, data analysis |
| Collaborator Contribution | Expertise in TB epidemiology, field studies |
| Impact | Design of current cluster-randomized trial including economic costing of intervention; ongoing analysis of previous trial. Disciplines involved - Epidemiology, public health, health economics |
| Start Year | 2010 |
| Description | TB China: CRT of medication monitor in TB case management |
| Organisation | Government of China |
| Department | Ministry of Health of the People's Republic of China |
| Country | China |
| Sector | Public |
| PI Contribution | Contributed to trial design, statistical support, data analysis |
| Collaborator Contribution | Expertise in TB epidemiology, field studies |
| Impact | Design of current cluster-randomized trial including economic costing of intervention; ongoing analysis of previous trial. Disciplines involved - Epidemiology, public health, health economics |
| Start Year | 2010 |
| Description | TB adherence |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration with Dr Helen Stagg on measuring adherence to TB treatment |
| Collaborator Contribution | Collaboration with Prof Katherine Fielding on measuring adherence to TB treatment |
| Impact | Multi-disciplinary: epidemiology, public health, statistics. Paper published- doi: 10.1513/AnnalsATS.201905-394OC |
| Start Year | 2018 |
| Description | TB042 |
| Organisation | Medical Research Council (MRC) |
| Department | MRC/UVRI and LSHTM Research Unit Uganda |
| Country | Uganda |
| Sector | Academic/University |
| PI Contribution | trial statistician |
| Collaborator Contribution | trial design and coordination; field activities |
| Impact | None yet. Multidisciplinary: public health, vaccines, clinical trials |
| Start Year | 2018 |
| Description | TB042 |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | trial statistician |
| Collaborator Contribution | trial design and coordination; field activities |
| Impact | None yet. Multidisciplinary: public health, vaccines, clinical trials |
| Start Year | 2018 |
| Description | TREATS |
| Organisation | HST |
| PI Contribution | Epidemiological and statistical input to study design and analysis. Liaison between TREATS and parent PopART trial. |
| Collaborator Contribution | Expertise in TB epidemiology, diagnostics, field studies and modelling |
| Impact | None yet. Multidisciplinary: Epidemiology, public health, diagnostics, modelling |
| Start Year | 2017 |
| Description | TREATS |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Epidemiological and statistical input to study design and analysis. Liaison between TREATS and parent PopART trial. |
| Collaborator Contribution | Expertise in TB epidemiology, diagnostics, field studies and modelling |
| Impact | None yet. Multidisciplinary: Epidemiology, public health, diagnostics, modelling |
| Start Year | 2017 |
| Description | TREATS |
| Organisation | International Union Against Tuberculosis and Lung Disease (The Union) |
| Country | Global |
| Sector | Academic/University |
| PI Contribution | Epidemiological and statistical input to study design and analysis. Liaison between TREATS and parent PopART trial. |
| Collaborator Contribution | Expertise in TB epidemiology, diagnostics, field studies and modelling |
| Impact | None yet. Multidisciplinary: Epidemiology, public health, diagnostics, modelling |
| Start Year | 2017 |
| Description | TREATS |
| Organisation | Royal Netherlands Chemical Society |
| Country | Netherlands |
| Sector | Learned Society |
| PI Contribution | Epidemiological and statistical input to study design and analysis. Liaison between TREATS and parent PopART trial. |
| Collaborator Contribution | Expertise in TB epidemiology, diagnostics, field studies and modelling |
| Impact | None yet. Multidisciplinary: Epidemiology, public health, diagnostics, modelling |
| Start Year | 2017 |
| Description | TREATS |
| Organisation | University of Sheffield |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Epidemiological and statistical input to study design and analysis. Liaison between TREATS and parent PopART trial. |
| Collaborator Contribution | Expertise in TB epidemiology, diagnostics, field studies and modelling |
| Impact | None yet. Multidisciplinary: Epidemiology, public health, diagnostics, modelling |
| Start Year | 2017 |
| Description | TREATS |
| Organisation | Zambia AIDS Related Tuberculosis |
| Country | Zambia |
| Sector | Academic/University |
| PI Contribution | Epidemiological and statistical input to study design and analysis. Liaison between TREATS and parent PopART trial. |
| Collaborator Contribution | Expertise in TB epidemiology, diagnostics, field studies and modelling |
| Impact | None yet. Multidisciplinary: Epidemiology, public health, diagnostics, modelling |
| Start Year | 2017 |
| Description | Targetted control to eliminate malaria in Senegal |
| Organisation | University Cheikh Anta Diop de Dakar |
| Country | Senegal |
| Sector | Academic/University |
| PI Contribution | Design and coordination and analysis of the cluster randomized trial |
| Collaborator Contribution | They led the coordination of field activities |
| Impact | The trial result will be available Q4 2015. This collaboration is multi-disciplinary involving epidemiology, statistics, economics, social science, clinical medicine, molecular biology, entomology, public health, parasitology. |
| Start Year | 2011 |
| Description | Trial to evaluate targeted parasite elimination (TPE) as a strategy to interrupt malaria transmission |
| Organisation | Clinton Health Access Initiative |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | Trial design; funding of vector control component through Wits University. |
| Collaborator Contribution | Funding of trial; logistics; trial management and governance |
| Impact | Trial protocol. Multi disciplinary - Epidemiology, Disease Control, Pharmacology, Entomology. Vector Control, Statistics. Modelling, Immunology |
| Start Year | 2015 |
| Description | Trial to evaluate targeted parasite elimination (TPE) as a strategy to interrupt malaria transmission |
| Organisation | National Vector-borne Diseases Control Programme (NVDCP) |
| Country | Namibia |
| Sector | Public |
| PI Contribution | Trial design; funding of vector control component through Wits University. |
| Collaborator Contribution | Funding of trial; logistics; trial management and governance |
| Impact | Trial protocol. Multi disciplinary - Epidemiology, Disease Control, Pharmacology, Entomology. Vector Control, Statistics. Modelling, Immunology |
| Start Year | 2015 |
| Description | Trial to evaluate targeted parasite elimination (TPE) as a strategy to interrupt malaria transmission |
| Organisation | University of California, San Francisco |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Trial design; funding of vector control component through Wits University. |
| Collaborator Contribution | Funding of trial; logistics; trial management and governance |
| Impact | Trial protocol. Multi disciplinary - Epidemiology, Disease Control, Pharmacology, Entomology. Vector Control, Statistics. Modelling, Immunology |
| Start Year | 2015 |
| Description | Trial to evaluate targeted parasite elimination (TPE) as a strategy to interrupt malaria transmission |
| Organisation | University of Namibia |
| Country | Namibia |
| Sector | Academic/University |
| PI Contribution | Trial design; funding of vector control component through Wits University. |
| Collaborator Contribution | Funding of trial; logistics; trial management and governance |
| Impact | Trial protocol. Multi disciplinary - Epidemiology, Disease Control, Pharmacology, Entomology. Vector Control, Statistics. Modelling, Immunology |
| Start Year | 2015 |
| Description | Trial to evaluate targeted parasite elimination (TPE) as a strategy to interrupt malaria transmission |
| Organisation | University of the Witwatersrand |
| Country | South Africa |
| Sector | Academic/University |
| PI Contribution | Trial design; funding of vector control component through Wits University. |
| Collaborator Contribution | Funding of trial; logistics; trial management and governance |
| Impact | Trial protocol. Multi disciplinary - Epidemiology, Disease Control, Pharmacology, Entomology. Vector Control, Statistics. Modelling, Immunology |
| Start Year | 2015 |
| Description | UT3C (Universal Testing and Treatment Trials Consortium) |
| Organisation | National Institute for Medical Research, Tanzania |
| Department | Mwanza Intervention Trials Unit (MITU) |
| Country | Tanzania, United Republic of |
| Sector | Public |
| PI Contribution | Coordination of Consortium. Chairing of Consortium calls. Partnering in joint analyses and publications between PopART and other UTT trials. |
| Collaborator Contribution | Partnering in joint analyses and publications. |
| Impact | Joint paper on UTT trial designs. Disciplines include epidemiology and public health. |
| Start Year | 2015 |
| Description | VMB S.Francis |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Principal investigator - leading the project |
| Collaborator Contribution | 16SrRNA sequencing; metabolomics; Luminex testing |
| Impact | 2 papers and more in progress.Multidisciplinary: Epidemiology and laboratory science |
| Start Year | 2013 |
| Description | VMB S.Francis |
| Organisation | The Wellcome Trust Sanger Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Principal investigator - leading the project |
| Collaborator Contribution | 16SrRNA sequencing; metabolomics; Luminex testing |
| Impact | 2 papers and more in progress.Multidisciplinary: Epidemiology and laboratory science |
| Start Year | 2013 |
| Description | Vanderbilt-collaboration |
| Organisation | Vanderbilt University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Study design |
| Collaborator Contribution | Study design |
| Impact | Discipline: Trial design |