A multi-country analysis of temperature-mortality associations from a climate change perspective

Lead Research Organisation: London Sch of Hygiene and Trop Medicine
Department Name: Epidemiology and Population Health

Abstract

Non-optimal outdoor temperature is a known risk factor for human health, with increased mortality risk associated with both high and low exposures. Several studies have attempted to quantify the related impact in a changing climate, considering the predicted increase in average temperature and extreme weather events. However, temperature-mortality associations show a substantial geographical and temporal heterogeneity that is still largely unexplained, and little is known about the factors determining vulnerability or resilience of populations to the effects of temperature. This information is critical to produce reliable impact projections under climate change, and to develop effective public health policies to attenuate the health burden. This project aims to address these research gaps by offering a systematic evaluation of the association and future impact of temperature on mortality across populations with markedly different characteristics. This project benefits from the availability of the largest data set ever collected for this purpose, including data from 384 locations within 13 countries between 1972 and 2012. Analyses will be based on flexible analytical methods recently developed for modelling complex temperature-health relationships. A first assessment will explore the role of climatological, demographic, socio-economic and infrastructural characteristics in modifying the mortality risk of temperature. This information will be used in second assessment to project the impact under composite scenarios accounting for potential changes in susceptibility due to secular trends and implementation of mitigation and adaptation strategies. This project will provide a comprehensive characterization of the health effects of temperature and the related climate change impact, and a platform to quantitatively evaluate the benefits of alternative public health policies and adaptation measures.

Technical Summary

Non-optimal outdoor temperature is a known risk factor for human health, with increased mortality risk associated with both high and low exposures. Several studies have attempted to quantify the related impact in a changing climate, considering the predicted increase in average temperature and extreme weather events. However, temperature-mortality associations show a substantial geographical and temporal heterogeneity that is still largely unexplained, and little is known about the factors determining vulnerability or resilience of populations to the effects of temperature. This information is critical to produce reliable impact projections under climate change, and to develop effective public health policies to attenuate the health burden. This project aims to address these research gaps by offering a systematic evaluation of the association and future impact of temperature on mortality across populations with markedly different characteristics. This project benefits from the availability of the largest data set ever collected for this purpose, including data from 384 locations within 13 countries between 1972 and 2012. Analyses will be based on flexible analytical methods recently developed for modelling complex temperature-health relationships. A first assessment will explore the role of climatological, demographic, socio-economic and infrastructural characteristics in modifying the mortality risk of temperature. This information will be used in second assessment to project the impact under composite scenarios accounting for potential changes in susceptibility due to secular trends and implementation of mitigation and adaptation strategies. This project will provide a comprehensive characterization of the health effects of temperature and the related climate change impact, and a platform to quantitatively evaluate the benefits of alternative public health policies and adaptation measures.

Planned Impact

The project will primarily benefit the community of researchers and public health practitioners working in academia, governmental health organisations or charities. The multi-country nature of the project, and the provision of projections of climate change impact at a small geographical scale including different scenarios of adaptation strategies, will ensure a large audience to the research findings, feeding a discussion about the possible public health responses. More generally, the results of this study will also benefit politicians, non-governmental organisations or members of associations involved in the discussion and decision-making. The question of climate change is a hotly debated topic, in which potential health consequences have to be considered within a broad assessment of economical, technical and societal issues. This study will offer scientific evidence on temperature-related health impact to inform such discussion.

Publications

10 25 50

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Oudin Åström D (2018) Investigating changes in mortality attributable to heat and cold in Stockholm, Sweden. in International journal of biometeorology

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Martínez-Solanas È (2018) Evaluation of the Impact of Ambient Temperatures on Occupational Injuries in Spain. in Environmental health perspectives

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Mitchell D (2018) Extreme heat-related mortality avoided under Paris Agreement goals. in Nature climate change

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Analitis A (2018) Synergistic Effects of Ambient Temperature and Air Pollution on Health in Europe: Results from the PHASE Project. in International journal of environmental research and public health

 
Description Modern methods for time series analysis
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Temperature, climate change and health
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Use of DLNMs in temperature-health studies
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
URL http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/10kxh85C77hGm5PFkch6qfQ/
 
Title Personal website 
Description The website provides access to the outputs of my research, such as pdf versions and supplemental material of the published papers, summaries and updates of my research activity, and other information. In particular, scripts and data for reproducing the results of methodological or substantive papers are made available thorough the website. 
Type Of Material Improvements to research infrastructure 
Year Produced 2012 
Provided To Others? Yes  
Impact The website is visited by 5-10 visitors each day. They download materials such as articles, scripts and data. 
URL http://www.ag-myresearch.com/
 
Title R package dlnm 
Description The package contains functions and data examples for running distributed lag non-linear models. It is provided within the free software R and downloadable from internet through the R program. 
Type Of Material Improvements to research infrastructure 
Year Produced 2009 
Provided To Others? Yes  
Impact The software implementation in a free program has boosted the use of DLNMs among researchers in different countries, primarily (but not only) for studies on temperature and air pollution. Also, the package, developed in parallel with the statistical framework, offer a vehicle to promote the methodology and its use among non-statisticians. 
URL http://cran.r-project.org/web/packages/dlnm/index.html
 
Title R package mvmeta 
Description The package contains functions and data examples for running univariate or multivariate meta-analysis and meta-regression. It is provided within the free software R and downloadable from internet through the R program. 
Type Of Material Improvements to research infrastructure 
Year Produced 2011 
Provided To Others? Yes  
Impact The software implementation in a free program facilitates the use of multivariate meta-analytical techniques in the research community. Also, the package, developed in parallel with the statistical framework, offer a vehicle to promote the methodology and its use among non-statisticians. 
URL http://cran.r-project.org/web/packages/mvmeta/index.html
 
Title Distributed lag non-linear models 
Description Flexible modelling technique for describing the temporal pattern of linear or non-linear exposure-response associations, termed exposure-lag-response associations. 
Type Of Material Data analysis technique 
Year Produced 2009 
Provided To Others? Yes  
Impact Huge impact on research on the health effects of temperature and other risk factors, certified by the use of the technique in several peer-reviewed articles by different research groups: http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/10kxh85C77hGm5PFkch6qfQ/ 
 
Title Multivariate meta-analysis 
Description Application of multivariate-meta-analysis to pool complex associations defined by multiple parameters 
Type Of Material Data analysis technique 
Year Produced 2012 
Provided To Others? Yes  
Impact Impact on applications of meta-analysis approaches, certified by the use of the technique in several peer-reviewed articles by different research groups: http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1bE6r3sM055G4oxSb_eqi8o/ 
 
Title Personal website 
Description The website provides access to the outputs of my research, such as pdf versions and supplemental material of the published papers, summaries and updates of my research activity, and other information. In particular, scripts and data for reproducing the results of methodological or substantive papers are made available thorough the website. 
Type Of Material Database/Collection of data 
Year Produced 2012 
Provided To Others? Yes  
Impact The website is visited by 5-10 visitors each day. They download materials such as articles, scripts and data. 
URL http://www.ag-myresearch.com/
 
Title R package dlnm 
Description The package contains functions and data examples for running distributed lag non-linear models. It is provided within the free software R and downloadable from internet through the R program. 
Type Of Material Computer model/algorithm 
Year Produced 2009 
Provided To Others? Yes  
Impact The software implementation in a free program has boosted the use of DLNMs among researchers in different countries, primarily (but not only) for studies on temperature and air pollution. Also, the package, developed in parallel with the statistical framework, offer a vehicle to promote the methodology and its use among non-statisticians. Huge impact on research on the health effects of temperature and other risk factors, certified by the use of the technique in several peer-reviewed articles by different research groups: http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1bE6r3sM055G4oxSb_eqi8o/ 
URL http://cran.r-project.org/web/packages/dlnm/index.html
 
Title R package mvmeta 
Description The package contains functions and data examples for running univariate or multivariate meta-analysis and meta-regression. It is provided within the free software R and downloadable from internet through the R program. 
Type Of Material Computer model/algorithm 
Year Produced 2011 
Provided To Others? Yes  
Impact The software implementation in a free program facilitates the use of multivariate meta-analytical techniques in the research community. Also, the package, developed in parallel with the statistical framework, offer a vehicle to promote the methodology and its use among non-statisticians. Impact on application of meta-analytical approaches, certified by the use of the technique in several peer-reviewed articles by different research groups: http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/10kxh85C77hGm5PFkch6qfQ/ 
URL http://cran.r-project.org/web/packages/mvmeta/index.html
 
Description Developing Methods to Enhance Environmental Epidemiological Risk Assessments 
Organisation Centers for Disease Control and Prevention (CDC)
Department Division of Parasitic Diseases and Malaria
Country United States 
Sector Public 
PI Contribution Technical contribution on statistical methods and software programs, intellectual contribution to publications
Collaborator Contribution Leading the development of the research project, leading on writing up of peer-review publications
Impact Not yet
Start Year 2014
 
Description Methodological work on distributed lag linear and non-linear models 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Leading the development of the methodological research, leading on writing up of peer-review publications
Collaborator Contribution Technical contribution on statistical methods and software programs, intellectual contribution to publications
Impact Peer-reviewed publications in international journals and oral presentations in international congresses
Start Year 2014
 
Description Methodological work on distributed lag linear and non-linear models 
Organisation Ludwig Maximilian University of Munich (LMU Munich)
Department Department of Neurology
Country Germany 
Sector Academic/University 
PI Contribution Leading the development of the methodological research, leading on writing up of peer-review publications
Collaborator Contribution Technical contribution on statistical methods and software programs, intellectual contribution to publications
Impact Peer-reviewed publications in international journals and oral presentations in international congresses
Start Year 2014
 
Description Modelling health effects of environmental exposures 
Organisation Children's Hospital of Philadelphia
Department Center for Pediatric Clinical Effectiveness
Country United States 
Sector Hospitals 
PI Contribution Technical contribution on statistical methods and software programs, intellectual contribution to publications
Collaborator Contribution Leading the development of the methodological research, leading on writing up of peer-review publications
Impact Peer-reviewed publications in international journals and oral presentations in international congresses
Start Year 2012
 
Description Modelling health effects of environmental exposures 
Organisation Columbia University
Department Department of Environmental Health Sciences
Country United States 
Sector Academic/University 
PI Contribution Technical contribution on statistical methods and software programs, intellectual contribution to publications
Collaborator Contribution Leading the development of the methodological research, leading on writing up of peer-review publications
Impact Peer-reviewed publications in international journals and oral presentations in international congresses
Start Year 2012
 
Description Modelling health effects of environmental exposures 
Organisation Harvard University
Department Harvard T.H. Chan School of Public Health
Country United States 
Sector Academic/University 
PI Contribution Technical contribution on statistical methods and software programs, intellectual contribution to publications
Collaborator Contribution Leading the development of the methodological research, leading on writing up of peer-review publications
Impact Peer-reviewed publications in international journals and oral presentations in international congresses
Start Year 2012
 
Description Modelling health effects of environmental exposures 
Organisation Public Health Agency of Canada
Department Canada Prenatal Nutrition Program
Country Canada 
Sector Public 
PI Contribution Technical contribution on statistical methods and software programs, intellectual contribution to publications
Collaborator Contribution Leading the development of the methodological research, leading on writing up of peer-review publications
Impact Peer-reviewed publications in international journals and oral presentations in international congresses
Start Year 2012
 
Description Modelling health effects of environmental exposures 
Organisation University of Hasselt
Department Centre for Environmental Sciences
Country Belgium 
Sector Academic/University 
PI Contribution Technical contribution on statistical methods and software programs, intellectual contribution to publications
Collaborator Contribution Leading the development of the methodological research, leading on writing up of peer-review publications
Impact Peer-reviewed publications in international journals and oral presentations in international congresses
Start Year 2012
 
Description Modelling health effects of environmental exposures 
Organisation University of Leuven
Department Department of Public Health and Primary Care
Country Belgium 
Sector Academic/University 
PI Contribution Technical contribution on statistical methods and software programs, intellectual contribution to publications
Collaborator Contribution Leading the development of the methodological research, leading on writing up of peer-review publications
Impact Peer-reviewed publications in international journals and oral presentations in international congresses
Start Year 2012
 
Description Modelling health effects of environmental exposures 
Organisation University of Ottawa
Country Canada 
Sector Academic/University 
PI Contribution Technical contribution on statistical methods and software programs, intellectual contribution to publications
Collaborator Contribution Leading the development of the methodological research, leading on writing up of peer-review publications
Impact Peer-reviewed publications in international journals and oral presentations in international congresses
Start Year 2012
 
Description Multi-Country Multi-City (MCC) Collaborative Research Network 
Organisation Harvard University
Department Harvard T.H. Chan School of Public Health
Country United States 
Sector Academic/University 
PI Contribution I have established and currently coordinating an international collaboration of more than 80 researchers from more than 40 countries, working on a program aiming to produce epidemiological evidence on associations between environmental stressors, climate, and health (http://mccstudy.lshtm.ac.uk/). The list of partners is long: see http://mccstudy.lshtm.ac.uk/participants/.
Collaborator Contribution It is collaborative network that has produced already important research outputs (http://mccstudy.lshtm.ac.uk/publications/).
Impact http://mccstudy.lshtm.ac.uk/publications/
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation Fudan University
Country China 
Sector Academic/University 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation Harvard University
Department Harvard T.H. Chan School of Public Health
Country United States 
Sector Academic/University 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation Lazio Regional Health Service
Country Italy 
Sector Public 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation Nagasaki University
Country Japan 
Sector Academic/University 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation National Taiwan University
Country Taiwan, Province of China 
Sector Academic/University 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation Public Health England
Country United Kingdom 
Sector Public 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation Queensland University of Technology (QUT)
Country Australia 
Sector Academic/University 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation Seoul National University
Country Korea, Republic of 
Sector Academic/University 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation Spanish National Research Council (CSIC)
Country Spain 
Sector Public 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation Umea University
Country Sweden 
Sector Academic/University 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation Universidade de São Paulo
Country Brazil 
Sector Academic/University 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation University of Ottawa
Country Canada 
Sector Academic/University 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation University of Queensland
Country Australia 
Sector Academic/University 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation University of Tsukuba
Country Japan 
Sector Academic/University 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description PHASE project 
Organisation Center for Research in Environmental Epidemiology
Country Spain 
Sector Academic/University 
PI Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact One peer-reviewed article: de' Donato FK, Leone M, Scortichini M, De Sario M, Katsouyanni K, Lanki T, Basagana X, Ballester F, Astrom C, Paldy A, Pascal M, Gasparrini A, Menne B, Michelozzi M. Changes in the effect of heat on mortality in the last 20 years in nine European cities. Results from the PHASE project. International Journal of Environmental Research and Public Health. 2015;12(12):15567-15583. Oral contributions in international conferences: Scortichini M, de'Donato F, Astrom DO, Basagana X, Gasparrini A, Iniguez C, Katsouyanni K, Lanki T, Paldy A, Pascal M, Michelozzi P, Analitis A. An annual comparison of the effects of summer temperatures on mortality for 9 European cities. International Society for Environmental Epidemiology (ISEE) Conference - Seattle, 24-28 August 2014. de'Donato F, Leone M, Analitis A, Paldy A, Lanki T, Gasparrini A, Pascal M, Astrom C, Ballester F, Basagana X, Michelozzi P. Temporal variations in the effect heat and cold, by age group and cause of death in 9 European cities. International Society for Environmental Epidemiology (ISEE) Conference - Seattle, 24-28 August 2014.
Start Year 2012
 
Description PHASE project 
Organisation Lazio Regional Health Service
Country Italy 
Sector Public 
PI Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact One peer-reviewed article: de' Donato FK, Leone M, Scortichini M, De Sario M, Katsouyanni K, Lanki T, Basagana X, Ballester F, Astrom C, Paldy A, Pascal M, Gasparrini A, Menne B, Michelozzi M. Changes in the effect of heat on mortality in the last 20 years in nine European cities. Results from the PHASE project. International Journal of Environmental Research and Public Health. 2015;12(12):15567-15583. Oral contributions in international conferences: Scortichini M, de'Donato F, Astrom DO, Basagana X, Gasparrini A, Iniguez C, Katsouyanni K, Lanki T, Paldy A, Pascal M, Michelozzi P, Analitis A. An annual comparison of the effects of summer temperatures on mortality for 9 European cities. International Society for Environmental Epidemiology (ISEE) Conference - Seattle, 24-28 August 2014. de'Donato F, Leone M, Analitis A, Paldy A, Lanki T, Gasparrini A, Pascal M, Astrom C, Ballester F, Basagana X, Michelozzi P. Temporal variations in the effect heat and cold, by age group and cause of death in 9 European cities. International Society for Environmental Epidemiology (ISEE) Conference - Seattle, 24-28 August 2014.
Start Year 2012
 
Description PHASE project 
Organisation National and Kapodistrian University of Athens
Country Greece 
Sector Academic/University 
PI Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact One peer-reviewed article: de' Donato FK, Leone M, Scortichini M, De Sario M, Katsouyanni K, Lanki T, Basagana X, Ballester F, Astrom C, Paldy A, Pascal M, Gasparrini A, Menne B, Michelozzi M. Changes in the effect of heat on mortality in the last 20 years in nine European cities. Results from the PHASE project. International Journal of Environmental Research and Public Health. 2015;12(12):15567-15583. Oral contributions in international conferences: Scortichini M, de'Donato F, Astrom DO, Basagana X, Gasparrini A, Iniguez C, Katsouyanni K, Lanki T, Paldy A, Pascal M, Michelozzi P, Analitis A. An annual comparison of the effects of summer temperatures on mortality for 9 European cities. International Society for Environmental Epidemiology (ISEE) Conference - Seattle, 24-28 August 2014. de'Donato F, Leone M, Analitis A, Paldy A, Lanki T, Gasparrini A, Pascal M, Astrom C, Ballester F, Basagana X, Michelozzi P. Temporal variations in the effect heat and cold, by age group and cause of death in 9 European cities. International Society for Environmental Epidemiology (ISEE) Conference - Seattle, 24-28 August 2014.
Start Year 2012
 
Description PHASE project 
Organisation Sorbonne University
Country France 
Sector Academic/University 
PI Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact One peer-reviewed article: de' Donato FK, Leone M, Scortichini M, De Sario M, Katsouyanni K, Lanki T, Basagana X, Ballester F, Astrom C, Paldy A, Pascal M, Gasparrini A, Menne B, Michelozzi M. Changes in the effect of heat on mortality in the last 20 years in nine European cities. Results from the PHASE project. International Journal of Environmental Research and Public Health. 2015;12(12):15567-15583. Oral contributions in international conferences: Scortichini M, de'Donato F, Astrom DO, Basagana X, Gasparrini A, Iniguez C, Katsouyanni K, Lanki T, Paldy A, Pascal M, Michelozzi P, Analitis A. An annual comparison of the effects of summer temperatures on mortality for 9 European cities. International Society for Environmental Epidemiology (ISEE) Conference - Seattle, 24-28 August 2014. de'Donato F, Leone M, Analitis A, Paldy A, Lanki T, Gasparrini A, Pascal M, Astrom C, Ballester F, Basagana X, Michelozzi P. Temporal variations in the effect heat and cold, by age group and cause of death in 9 European cities. International Society for Environmental Epidemiology (ISEE) Conference - Seattle, 24-28 August 2014.
Start Year 2012
 
Description PHASE project 
Organisation Umea University
Country Sweden 
Sector Academic/University 
PI Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact One peer-reviewed article: de' Donato FK, Leone M, Scortichini M, De Sario M, Katsouyanni K, Lanki T, Basagana X, Ballester F, Astrom C, Paldy A, Pascal M, Gasparrini A, Menne B, Michelozzi M. Changes in the effect of heat on mortality in the last 20 years in nine European cities. Results from the PHASE project. International Journal of Environmental Research and Public Health. 2015;12(12):15567-15583. Oral contributions in international conferences: Scortichini M, de'Donato F, Astrom DO, Basagana X, Gasparrini A, Iniguez C, Katsouyanni K, Lanki T, Paldy A, Pascal M, Michelozzi P, Analitis A. An annual comparison of the effects of summer temperatures on mortality for 9 European cities. International Society for Environmental Epidemiology (ISEE) Conference - Seattle, 24-28 August 2014. de'Donato F, Leone M, Analitis A, Paldy A, Lanki T, Gasparrini A, Pascal M, Astrom C, Ballester F, Basagana X, Michelozzi P. Temporal variations in the effect heat and cold, by age group and cause of death in 9 European cities. International Society for Environmental Epidemiology (ISEE) Conference - Seattle, 24-28 August 2014.
Start Year 2012
 
Description PHASE project 
Organisation University of Valencia
Country Spain 
Sector Academic/University 
PI Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact One peer-reviewed article: de' Donato FK, Leone M, Scortichini M, De Sario M, Katsouyanni K, Lanki T, Basagana X, Ballester F, Astrom C, Paldy A, Pascal M, Gasparrini A, Menne B, Michelozzi M. Changes in the effect of heat on mortality in the last 20 years in nine European cities. Results from the PHASE project. International Journal of Environmental Research and Public Health. 2015;12(12):15567-15583. Oral contributions in international conferences: Scortichini M, de'Donato F, Astrom DO, Basagana X, Gasparrini A, Iniguez C, Katsouyanni K, Lanki T, Paldy A, Pascal M, Michelozzi P, Analitis A. An annual comparison of the effects of summer temperatures on mortality for 9 European cities. International Society for Environmental Epidemiology (ISEE) Conference - Seattle, 24-28 August 2014. de'Donato F, Leone M, Analitis A, Paldy A, Lanki T, Gasparrini A, Pascal M, Astrom C, Ballester F, Basagana X, Michelozzi P. Temporal variations in the effect heat and cold, by age group and cause of death in 9 European cities. International Society for Environmental Epidemiology (ISEE) Conference - Seattle, 24-28 August 2014.
Start Year 2012
 
Title R package dlnm 
Description The package contains functions and data examples for running distributed lag non-linear models. The software is freely downloadable by everybody, and it is licensed under the GNU General Public License, meaning that, under appropriate reference and the assurance that novel material is provided under the same licence terms, it can be modified and extended by other researchers. 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted 2009
Licensed Yes
Impact The software implementation in a free program has boosted the use of DLNMs among researchers in different countries, primarily (but not only) for studies on temperature and air pollution. Also, the package, developed in parallel with the statistical framework, offer a vehicle to promote the methodology and its use among non-statisticians.
 
Title R package mvmeta 
Description The package contains functions and data examples for running univariate or multivariate meta-analysis and meta-regression. The software is freely downloadable by everybody, and it is licensed under the GNU General Public License, meaning that, under appropriate reference and the assurance that novel material is provided under the same licence terms, it can be modified and extended by other researchers. 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted 2011
Licensed Yes
Impact The software implementation in a free program facilitates the use of multivariate meta-analytical techniques in the research community. Also, the package, developed in parallel with the statistical framework, offer a vehicle to promote the methodology and its use among non-statisticians.
 
Title R package dlnm 
Description The package contains functions and data examples for running distributed lag non-linear models. It is provided within the free software R and downloadable from internet through the R program. 
Type Of Technology Software 
Year Produced 2009 
Open Source License? Yes  
Impact The software implementation in a free program has boosted the use of DLNMs among researchers in different countries, primarily (but not only) for studies on temperature and air pollution. Also, the package, developed in parallel with the statistical framework, offer a vehicle to promote the methodology and its use among non-statisticians. 
URL http://cran.r-project.org/web/packages/dlnm/index.html
 
Title R package mvmeta 
Description The package contains functions and data examples for running univariate or multivariate meta-analysis and meta-regression. It is provided within the free software R and downloadable from internet through the R program. 
Type Of Technology Software 
Year Produced 2011 
Open Source License? Yes  
Impact The software implementation in a free program facilitates the use of multivariate meta-analytical techniques in the research community. Also, the package, developed in parallel with the statistical framework, offer a vehicle to promote the methodology and its use among non-statisticians. 
URL http://cran.r-project.org/web/packages/mvmeta/index.html
 
Description Centre for Statistical Modelling (CSM) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Centre of the London School of Hygiene & Tropical Medicine

Seminars and other activities are usually attended by 50-100 researchers, PhD or MSc students
Year(s) Of Engagement Activity 2011,2012,2013,2014,2015,2016,2017,2018,2019,2020
URL http://csm.lshtm.ac.uk/
 
Description Invited talks 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Series of invited talks and workshops in well-known research institutions and companies, such as Harvard School of Public Health, Karolinska Institute, Royal Statistical Society, The Children Hospital of Philadelphia, Centre for Research in Environmental Epidemiology (CREAL), University of Pennsylvania, Ludwig Maximilians University, Swiss Tropical and Public Health Institute, Open University, St George's University of London, IQVIA, European Centre for Medium-Range Weather Forecasts (ECMWF), Centers for Disease Control and Prevention (CDC), Emory University
Year(s) Of Engagement Activity 2010,2011,2012,2013,2014,2015,2016,2017,2018,2019,2020