VAccine deveLopment for complex Intracellular neglecteD pAThogEns (VALIDATE)

Lead Research Organisation: University of Oxford
Department Name: The Jenner Institute

Abstract

For several complex pathogens, we have an incomplete understanding of the kind of immune response we need an effective vaccine to induce. In part this is because these pathogens live inside cells and can hide from the host immune response. This makes it very difficult to develop vaccines against these pathogens. The diseases caused by these pathogens, including tuberculosis (TB), leprosy, leishmaniasis and melioidosis, disproportionately affect people in low and middle-income countries (LMICs) and are often neglected due to the poor predicted commercial return and marginalisation of affected populations. The current approach to vaccine development is to identify a part of the immune response that might be important, develop vaccines that induce that kind of immune response and then test that vaccine to see if it works, first in animal models and then in human clinical trials. This approach does not work for these complex pathogens and is slow and inefficient. In this Network we will adopt an iterative approach and develop more accurate working models of the immune response by cycles of repeated integration of data from human clinical studies and animal models across the different pathogens. The inclusion of vets working in large animal models will mean the results obtained are relevant for the development of animal vaccines as well. The inclusion of partners from LMIC where these diseases are endemic, together with partners from industry will help ensure real world relevance. Furthermore, the smaller animal models will allow us to easily look at single components of the immune system. The insight gained into immune mechanisms will allow us to design and develop vaccines more efficiently and more effectively.

This Network will provide a unique opportunity to bring together individuals working on four exemplar complex intracellular pathogens (M.tb, M.leprae, Leishmania spp. and B.pseudomallei), which share a common lifestyle as pathogens that live in a particular host cell called macrophages, induce similar end-stage pathologies in humans and are known to affect host immune and metabolic responses. The horizontal collaborations established throughout this network, together with the provision of a protected environment for early data sharing, will exploit the biological synergies between these pathogens. Positive and negative results can be disseminated rapidly, and partners working on each of the complex diseases can learn from the successes and failures of those working on the other diseases. By understanding mechanisms that lead from infection to disease, we plan to uncover common approaches to inform vaccine development strategies for these and other complex intracellular pathogens.

Key Network activities and deliverables include annual meetings for knowledge sharing; creation of a virtual network for real-time data sharing; pump-priming funding to fill knowledge gaps, and provide data to enhance the competitiveness of larger grant applications; a website and other communications to enhance collaborations and research dissemination; and career development by funding, training and mentoring of early post-doctoral and new PI researchers. All activities work towards more effective vaccine development for these important diseases, and the improvement of research capabilities in our partner LMICs.

Technical Summary

For several complex intracellular pathogens, we have an incomplete understanding of protective immunity. These diseases, including TB, leprosy, leishmaniasis and melioidosis, disproportionately affect LMICs and are often neglected due to the poor predicted commercial return and marginalisation of affected populations. The current linear approaches, which identify a component of the immune response, induce it by vaccination and evaluate efficacy in animal models and clinical trials, are flawed and have proven inefficient for intracellular pathogens. In this Network we will adopt an iterative approach and develop accurate working models of immunity by repeated integration of data from human experimental studies and animal models across the different pathogens. Veterinary vaccinologists and large animal models will facilitate the One Health agenda, and experimental medicine studies and LMIC and industrial partners will ensure relevance and translational value. The smaller animal models will provide the tools with which to easily dissect mechanisms and immune pathways. The integrated approach incorporates in-silico and in-vitro tools to delineate mechanisms, that will feed directly into vaccine design and development.

This Network will provide a unique opportunity to bring together individuals working on four exemplar complex intracellular pathogens (M.tb, M.leprae, Leishmania spp. and B.pseudomallei), which share a common lifestyle as pathogens of macrophages, induce similar end-stage pathologies (granulomatous inflammation, tissue remodeling) and alter host immune and metabolic responses. The horizontal collaborations established throughout this network, together with the provision of a protected environment for early data sharing, will exploit the biological synergies. By interrogating mechanisms that lead from infection to disease, we plan to uncover common approaches to inform vaccine development strategies for these and other complex intracellular pathogens.

Planned Impact

There are many beneficiaries of the work carried out under this Network.

The first obvious beneficiaries of this work are basic scientists, clinicians, veterinarians, epidemiologists and clinical trial investigators working in the field of vaccinology, particularly vaccines for the exemplar pathogens that are the focus of this Network. The scientific data sharing, pump-priming funding, and support to existing and new collaborations that are all supported by this Network will lead to new scientific insights which will facilitate vaccine research and development. The networking activities are designed to maximise the impact of the Network. Furthermore, the academic community will gain from the training, mentoring and knowledge sharing that will occur as part of this network.

Industrial colleagues in vaccinology will also benefit from this work, both in SMEs and in large pharmaceutical companies. Industrial involvement in these complex pathogens is currently limited, in part because of a predicted poor return on investment. This Network aims to 'de-risk' vaccine development by providing novel insights into host immunity and in sharing across pathogens any lessons learned so the broader applicability of any novel findings can be rapidly evaluated.

Ultimately, this Network will 'de-risk' vaccine development for complex intracellular pathogens and allow the design and development of vaccine candidates that are more likely to succeed. The development of effective vaccines for any of the pathogens outlined here would have a very significant impact on global mortality and morbidity, particularly in LMIC where these diseases are endemic. The health and ultimately wealth of LMIC will improve with the development of effective vaccines against these devastating pathogens.

Policy makers, in the UK and LMIC, together with the funders of scientific research, also have the potential to benefit from the work outlined in this Network. The insights gained will allow better selection and prioritisation of vaccine candidates at an earlier stage, and a greater likelihood of success.

Organisations

 
Description Liaison with MPs
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
URL https://www.validate-network.org/un-high-level-tb-meeting-2018
 
Description Industrial Challenge Strategy Fund
Amount £600,000 (GBP)
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 03/2018 
End 03/2019
 
Description NIHR Senior Investigator - Prof Helen McShane (ref NIHR200225)
Amount £60,000 (GBP)
Funding ID NIHR200225 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2019 
End 03/2023
 
Title Sharing of documents with other GCRF networks 
Description Items shared with the other GCRF Vaccine Networks (HIC-VAC, Bactivac, IMPRINT, IVVN) to streamline their processes and help them with their procedural set up: VALIDATE pump-priming call template and guidance documents, training grant template and guidance (all shared with BBSRC Vector Networks as well), Network Management Board confidentiality agreement, tiered membership structure, membership and members' directory templates, member terms & conditions, first annual meeting agenda, as well as being asked for feedback and lessons learned from our various grant calls and procedures. 
Type Of Material Improvements to research infrastructure 
Year Produced 2018 
Provided To Others? No  
Impact The sharing of our documents enabled the other networks to more quickly and easily set up their processes and procedures, and template documents. 
 
Title VALIDATE Data Sharing Portal and VALIDATE Research Data Analyst 
Description In January 2019 we launched the VALIDATE Data Sharing Portal, which aims to facilitate and encourage the sharing of published and unpublished data amongst our members, to enable cross-comparisons (e.g. of similar assays across pathogens, or across assays for one pathogen, or across species or countries) that will accelerate vaccine development, as well as to avoid duplication of effort where unpublished negative data already exists. Our VALIDATE Research Data Analyst is in charge of the database and will further optimise its processes, and facilitate the uploading and analyses of data by our members. 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
Impact We have several publications in progress that have arisen from data sharing amongst VALIDATE members and advanced analyses performed by our Research Data Analyst. 
URL https://www.validate-network.org/data-sharing-portal
 
Description VALIDATE members 
Organisation Abbottabad University of Science and Technology
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Aberystwyth University
Country United Kingdom 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Addis Ababa University
Country Ethiopia 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Advantage Bio Consultants Inc
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Animal and Plant Health Agency
Country United Kingdom 
Sector Public 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Armauer Hansen Research Institute
Country Ethiopia 
Sector Charity/Non Profit 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation B.P. Koirala Institute of Health Sciences
Country Nepal 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Banaras Hindu University
Country India 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Barcelona Institute for Global Health
Country Spain 
Sector Multiple 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Baylor College of Medicine
Country United States 
Sector Hospitals 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC)
Country United Kingdom 
Sector Public 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation British Society For Immunology
Country United Kingdom 
Sector Learned Society 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Central University of Rajasthan
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Centre for Biological Research (CIB)
Country Spain 
Sector Public 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Centre for Infectious Disease Research in Zambia
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Certara, L.P.
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Covenant University
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Defence Science & Technology Laboratory (DSTL)
Country United Kingdom 
Sector Public 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Dhaka Medical College and Hospital
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Ebonyi State University
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Eduardo Mondlane University
Country Mozambique 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Elizade University
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Federal Polytechnic
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Federal Teaching hospital Abakaliki
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Federal University of Bahia
Country Brazil 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Federal University of Minas Gerais
Country Brazil 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Federal University of Rio de Janeiro
Country Brazil 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Francis Crick Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Hull York Medical School
Country United Kingdom 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Immunobiology Ltd, Babraham, UK
Country United Kingdom 
Sector Private 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Immunocore Ltd
Country United Kingdom 
Sector Private 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Infectious Disease Research Institute (IDRI)
Country United States 
Sector Charity/Non Profit 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Infectious Diseases Research Collaboration (IDRC)
Country Uganda 
Sector Charity/Non Profit 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation KEM Hospital Research Centre
Country India 
Sector Hospitals 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Kebbi State University of Science and Technology
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Khon Kaen University
Country Thailand 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Leiden University Medical Center
Country Netherlands 
Sector Multiple 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation MRC/UVRI Uganda Research Unit on AIDS
Country Uganda 
Sector Public 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Mahidol University
Country Thailand 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Manhiça Health Research Centre (CISM)
Country Mozambique 
Sector Charity/Non Profit 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Moredun Research Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Mount Kenya University
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation National Institute for Biological Standards and Control (NIBSC)
Country United Kingdom 
Sector Public 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation National Veterinary Research Institute, Nigeria
Country Nigeria 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Nepal Medical College Teaching Hospital
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Oswaldo Cruz Foundation (Fiocruz)
Country Brazil 
Sector Public 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Oxford Immunotec Global
Country United Kingdom 
Sector Private 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Pasteur Institute, Lille
Country France 
Sector Charity/Non Profit 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Public Health England
Country United Kingdom 
Sector Public 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation QIMR Berghofer Medical Research Institute
Country Australia 
Sector Multiple 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Queen's University Belfast
Country United Kingdom 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Red Sea University
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Royal Veterinary College (RVC)
Country United Kingdom 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Simomics Ltd
Country United Kingdom 
Sector Private 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Sindh Agriculture University
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation St George's University of London
Country United Kingdom 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation The Federal Institute for Drugs and Medical Devices
Country Germany 
Sector Public 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University College Dublin
Country Ireland 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University Libre Bruxelles (Université Libre de Bruxelles ULB)
Country Belgium 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of Buea
Country Cameroon 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of Cape Town
Country South Africa 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of Colombo
Country Sri Lanka 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of Debrecen
Country Hungary 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of Florida
Country United States 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of Ghana
Country Ghana 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of Ibadan
Country Nigeria 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of Indonesia
Country Indonesia 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of Leicester
Country United Kingdom 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of Milan
Country Italy 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of Nevada
Department School of Medicine
Country United States 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of Oxford
Department Oxford University Clinical Research Unit Vietnam (OUCRU)
Country Viet Nam 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of Pavia
Country Italy 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of Rajshahi
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of Reading
Country United Kingdom 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of Sao Paulo
Country Brazil 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of Southampton
Country United Kingdom 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of Sri Jayawardanapura
Country Sri Lanka 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of Stellenbosch
Country South Africa 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of Surrey
Country United Kingdom 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of Texas
Department University of Texas Medical Branch
Country United States 
Sector Hospitals 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of Veterinary & Animal Sciences
Country Pakistan 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of Washington
Country United States 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of Western Australia
Country Australia 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of York
Country United Kingdom 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation University of the Punjab
Country Pakistan 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Vaccitech Ltd
Country United Kingdom 
Sector Private 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description VALIDATE members 
Organisation Vietnam National University
Country Viet Nam 
Sector Academic/University 
PI Contribution I am Co-Director, with Prof Helen Fletcher from LSHTM, of the VALIDATE Network.
Collaborator Contribution The 221 members of VALIDATE come from the above institutes, comprising academia, governmental and non-governmental organisations, industry, and other types of organisation from 38 countries (25 LMIC). We are particularly pleased that our gender balance in the VALIDATE network is good, with 105 women and 116 men.
Impact All aspects of VALIDATE listed in this grant report have resulted from this partnership. This is a multi-disciplinary collaboration, involving biomedical scientists (clinical trialists, human immunologists, animal and human modellers, basic scientists), veterinarians, bioinformaticians and computer modellers, social scientists, epidemiologists, structural biologists and chemists.
Start Year 2017
 
Description Representation of VALIDATE at Events, Workshops or similar 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact VALIDATE has been represented at various events to promote our network and encourage new membership, as well as to speak to funding bodies about our work:

29 Jan 2019, Director Prof Helen McShane met with Ole Olesen at EDCTP to discuss VALIDATE.

29 Jan 2019, Director Prof Helen McShane gave a talk about VALIDATE at the TBVAC2020 Les Diablerets meeting, as part of the TBVI Symposium "TB Vaccines Global Collaboration and Recent Advances in the Field."

9 Jan 2019, representation of VALIDATE by Network Director Prof Helen McShane and Network Management Board member Prof Paul Kaye at HIC-VAC Regulatory Workshop "Human challenge agents: scoping potential manufacturing guidelines".

12 Nov 2018, Prof Helen McShane and Samantha Vermaak met with Prof Sarah Rowland-Jones, President of RSTMH, to discuss how our two networks could work together to mutual benefit.

10 Oct 2018, Prof Helen McShane and Samantha Vermaak had a teleconference with Willem Hanekom and Anne Kasmar at the Gates Foundation re VALIDATE.

25 Sep 2018, Network Manager Samantha Vermaak gave a talk about VALIDATE at the IMPRINT 2nd Annual Meeting (leaflets available too).

19 Sep 2018, Network Manager Samantha Vermaak gave a talk about VALIDATE at the 9th EDCTP Forum.

30 Jul 2018, Helen McShane and Samantha Vermaak attended the MRC GCRF Vaccine Network first year meeting.

5 Jul 2018, VALIDATE Network Manager Samantha Vermaak gave a talk about VALIDATE at the Acid Fast Club meeting.

10 May 2018, VALIDATE Research Data Analyst Dr Deniz Cizmeci gave a talk about VALIDATE at an IDDO meeting.

19 Apr 2018, VALIDATE Co-Director Prof Helen Fletcher gave a careers talk to 30+ PhD students from LSHTM/UCL, mentioning VALIDATE.

26-27 Mar 2018, VALIDATE Network Management Board member Prof Paul Kaye mentioned VALIDATE in his talk at IVVN's 1st Annual Meeting (leaflets at meeting).

23 Mar 2018, VALIDATE Director Prof Helen McShane had VALIDATE slide at UCL/LSHTM/UCSF World TB Day Super-Symposium https://panopto.lshtm.ac.uk/Panopto/Pages/Viewer.aspx?id=5ddad554-12f4-42e3-bab8-8bdc83ecbfb2

20 Mar 2018, VALIDATE talk by Network Manager Samantha Vermaak at European Melioidosis Congress. Our Associate Dr Panjaporn Chaichana (MORU, Thailand) also presented her VALIDATE-funded research and thanked VALIDATE for our funding.

26-27 Feb 2018, VALIDATE talk by Director Prof Helen McShane at Bactivac Annual Meeting (leaflets too).

22 Feb 2018, VALIDATE leaflets and representation (Samantha Vermaak) at University of Oxford's 'Global Research Day: Tackling International Challenges" event.

12 Feb 2018, VALIDATE Co-Director Prof Helen Fletcher had a slide about VALIDATE in her talk at the UCL-AHRI Symposium "Towards HIV and TB elimination in South Africa".

18 Jan 2018, VALIDATE Director Prof Helen McShane mentioned VALIDATE in her talk at the UK Veterinary Vaccinology Network Conference, and had leaflets.

15 Jan 2018, VALIDATE Director Prof Helen McShane presented a slide about VALIDATE, and had leaflets at the event to promote VALIDATE.

5 Dec 2017, VALIDATE Network Manager Samantha Vermaak co-hosted a stand at the BSI Congress with the other GCRF MRC-funded Vaccine Networks, with a pull-up banner and leaflets about VALIDATE, speaking to the event delegates about our Network and the benefits of membership.

23-24 Nov 2017, talk about VALIDATE given by Dr Iman Satti (VALIDATE Associate) at HIC-VAC 1st Annual Meeting.

30 Jul 2017, VALIDATE Management Team Prof Helen McShane (Director), Prof Helen Fletcher (Co-Director) and Samantha Vermaak (Network Manager) attended the MRC Vaccines Network meeting in London hosted by MRC.
Year(s) Of Engagement Activity 2017,2018,2019
 
Description VALIDATE 1st Annual Meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact On 5-6 Sept 2017 we hosted our first VALIDATE Annual Meeting, with 35 members attending from 5 countries (UK, India, Brazil, Thailand, and Uganda), plus our 3 Scientific Advisory Board members. We awarded 3 travel scholarships to facilitate LMIC attendees. This was a fantastic opportunity for our members to meet face-to-face, many for the first time, and it gave our Management Team a chance to showcase VALIDATE and its aims, vision, and upcoming grant calls, as well as all the opportunities and benefits we provide for our members. We had talks by world-leading researchers about each of our focus pathogens (to spark cross-pathogen thinking), presentations by our industry partners (to spark academic-industry collaborations), a speed-dating session (to facilitate new collaborations and networking), as well as a session to find out what workshops our members would find useful, and a Dragons Den style session where we showcased the type of pump-priming projects VALIDATE was looking for (to encourage successful ideas and applications from our members), followed by a session that facilitated cross-pathogen discussion and idea sharing to set up future pump-priming ideas. We had positive feedback from our members about the relevance and usefulness of this first meeting, and it was a very successful couple of days for jump-starting our Network and engaging our members in this new community.
Year(s) Of Engagement Activity 2017
URL https://www.validate-network.org/annual-meeting#collapse1-0
 
Description VALIDATE 2nd Annual Meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact On 6-7th November 2018, we held our 2nd Annual Meeting in York, UK. The meeting contained updates about VALIDATE, Prof Heidi Larson (LSHTM) talking about vaccine hesitancy, our pump-priming funded projects each giving an update about their research, as well as some animated and engaged networking to get our members meeting each other and sparking collaboration ideas. We had an ECR showcase, where our network's ECRs hosted posters outlining their current research and future career and research ambitions to facilitate and spark new collaborative relationships amongst our members and to network them with both their peers and senior scientists and PIs in VALIDATE. We also had an industry showcase where our industry members had posters highlighting their research experience and expertise, again to network them in with other members.

On day 2 we held a facilitated 'Ideas Laboratory' aiming to help our delegates think big to tackle vaccine development for our focus pathogens - what breakthroughs need to be achieved, what challenges need to be overcome, what do we need to start/stop/continue doing to achieve success? The room buzzed with energy as people exchanged ideas, gradually building up to concrete research project concepts that everyone worked collaboratively on to develop further, and some of which have been submitted as pump-priming grants in our subsequent round of funding.

62 delegates from 13 countries (Brazil, Cameroon, Ireland, Italy, Mexico, Mozambique, Nepal, Nigeria, South Africa, Thailand, Uganda, UK, USA) attended, as well as two members of our SAB. We awarded 9 travel scholarships to LMIC members to encourage and facilitate their attendance (7 to female scientists), 7 or which were to ECRs.

The meeting had excellent feedback from our members. We also used the meeting to produce three short videos, showcasing VALIDATE to encourage further new members to join and to highlight the benefits of VALIDATE membership (viewable at https://www.youtube.com/channel/UC4jnwrHLkvK-xJjYJYpnYog).
Year(s) Of Engagement Activity 2018
URL https://www.validate-network.org/article/validate-2nd-annual-meeting-report
 
Description VALIDATE LinkedIn 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact We have set up a closed LinkedIn VALIDATE group with three aims:
1. To make it easier for our members to connect to each other.
2. To create a further social media forum on a different platform for dissemination of relevant and interesting news as well as VALIDATE outputs, to reach members who may not be using Twitter.
3. To add a way to keep up to date with outputs and news from our members e.g. job vacancies are often posted to LinkedIn, that we can then share and also publicise on our website and Twitter accounts.

Currently 82 of our members have connected and are now following our account.
Year(s) Of Engagement Activity 2018,2019
URL https://www.linkedin.com/in/validate-network/
 
Description VALIDATE Seminars 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact VALIDATE aims to host regular seminars by our members about their research to inform members and the general public, and to spark new research ideas and collaborations. These are live-streamed online to enable all our members and the general public, no matter where they are based in the world, to join and benefit from the information, ideas, and findings being disseminated.

Our first talk was held on 6 Dec 2017, by Assoc Prof Helen Fletcher and Dr Andrea Zelmer at LSHTM, entitled "Correlates of risk of TB disease and their back-translation into animal models", and was viewed by c.43 people.

Our second talk was held on 15 Feb 2019, by Prof Helen McShane and Dr Rachel Tanner at University of Oxford, entitled "Developing a better vaccine against TB" and was viewed by 52 unique viewers.
Year(s) Of Engagement Activity 2017,2019
URL https://www.validate-network.org/seminars
 
Description VALIDATE Twitter account 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact On 28 July 2017 we launched our VALIDATE Twitter account @NetworkVALIDATE. We post regularly about news, opinions and activities relevant to our Network members, including grant calls, training opportunities, events, journal articles, opinion pieces, tips/advice, and disease stats from VALIDATE and relevant external organisations, to promote both our activities and items that could help our members advance their research and careers - or inform general public followers about our research, vaccine development, vaccine hesitancy etc. To date we have 457 followers, which we hope to continue to increase.
Year(s) Of Engagement Activity 2017,2018,2019
URL https://twitter.com/NetworkValidate
 
Description VALIDATE in the spotlight - in writing 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact 8 Mar 2019, VALIDATE blog post for International Women's Day 2019 interviewing 5 of our female scientists https://www.validate-network.org/article/international-womens-day-2019

26 Nov 2018, VALIDATE featured in RSTMH newsletter

18 Jun 2018, VALIDATE Director Helen McShane spoke to www.openaccessgovernment.org about "The current status of tuberculosis vaccine development" https://www.openaccessgovernment.org/current-status-tuberculosis-vaccine-development/46726/

30 Apr 2018, VALIDATE blog post for World Immunization week https://www.validate-network.org/article/vaccineswork-world-immunization-week-vaccines-validate

5 Dec 2017, VALIDATE featured in a blog post "Building international partnerships to tackle disease" on the University of Oxford Science blog, which has an extensive worldwide reach. http://www.ox.ac.uk/news/science-blog/building-international-partnerships-tackle-disease

22 Nov 2017, VALIDATE featured in article on GCRF Networks by Martin Broadstock for BSI Immunology News magazine https://www.immunology.org/news/the-network-effect-promoting-collaborative-research?utm_content=buffer15fca&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer

24 Oct 2017, VALIDATE launch featured on TBVI website 'news' https://www.tbvi.eu/new-international-vaccine-rd-network-validate/
Year(s) Of Engagement Activity 2017,2018,2019
 
Description VALIDATE in the spotlight - media 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact 4 Dec 2018, VALIDATE launched its You Tube Channel, with videos of our members talking about VALIDATE and the benefits of membership, to promote our network in another format and to hopefully encourage new members to join VALIDATE. https://www.youtube.com/channel/UC4jnwrHLkvK-xJjYJYpnYog

24 Mar 2018, VALIDATE Director Prof Helen McShane gave an interview for World TB Day at BBCOxford Radio https://www.bbc.co.uk/programmes/p060zj9g 1:02:30 for the headline; 1:09:05 for the interview.
Year(s) Of Engagement Activity 2018,2019
 
Description VALIDATE website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact On 28 July 2017 we launched the VALIDATE Network website www.validate-network.org. The website publicises our network, our members (including a searchable members' directory to facilitate new collaborations), our funding opportunities, events, our mentoring scheme, projects and grants we have funded, seminars and workshops provided, external funding and training/job opportunities relevant to our members, and a weekly round-up of new grant calls/jobs/training/events and news. According to Google Analytics, to date the website has been viewed by 19,994 users from 173 countries.

Our aim is to make our website a central 'go to' hub for all relevant information for researchers working in our field (from academia, industry, government and non-profits), and for it to act as a hub of reliable information about vaccine research and our focus diseases for the general public and other interested parties. We have already had 3 ECR members feedback outputs from our website information (all LMIC members) - one saw the Newton Travel Award listed in our external grants list and applied for and was awarded a grant; a second ECR member (from Uganda) applied for the "Data Management for Early Career Researchers" workshop in Nairobi that we listed in our training opportunities and was given a place and has now attended this course; while a 3rd ECR member from Cameroon applied for the Oxford University summer internship 2019 programme, having seen it advertised on the VALIDATE website.
Year(s) Of Engagement Activity 2017,2018,2019
URL http://www.validate-network.org
 
Description VALIDATE work experience 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact In February 2019 a Six Form student from a school in Surrey attended two days' work experience/shadowing at the Jenner Institute, visiting the laboratories and the clinical trial clinics and talking to staff about their research and careers in science, after contacting VALIDATE with a request to visit. This hopefully helped Zack with choosing his degree and future career plans.
Year(s) Of Engagement Activity 2017,2019