IMPRINT: IMmunising PRegnant women and INfants neTwork

Lead Research Organisation: Imperial College London
Department Name: Dept of Medicine

Abstract

Far too many newborns continue to die in early life, particularly in low-and middle income countries (LMIC). Many die from infections, some of which could be prevented. During the late stages of pregnancy, antibody is transferred across the placenta from mother to child, providing protection to the infant in the early weeks of life. However, if the mother has insufficient protection against certain infections, the infant will also not be protected.

Vaccinating women in pregnancy can enhance the level of antibody in the mother, thereby protecting the mother, and increasing the amount of antibody transferred across the placenta - protecting the infant from birth too. This concept has already been successfully established for the prevention of tetanus, influenza and pertussis (whooping cough). Many investigators and stakeholders are interested in using this strategy to protect infants from other serious infections, for example group B streptococcus or respiratory syncytial virus (RSV), and vaccines against these infections are in development. Some fundamental gaps in our understanding remain about the immune response to vaccines in pregnancy and in newborn infants which are essential for us to address in order to accelerate development of new vaccines. It is also very important that the scientific community tackles how best to implement such vaccine programmes in both high-income countries and LMIC.

Our unique inter-disciplinary network represents stakeholders from basic science, immunology, vaccinology, social sciences, industry, public health and national and international policy makers who have come together in order to tackle the key challenges in the best use of vaccines in pregnancy and in newborns, and in the long term, improve maternal and newborn health.

Specifically, the IMPRINT network will implement collaborative research projects to answer fundamental biological questions about antibody transfer of antibody across the placenta, how to induce the "best" antibody, and its effect on the maturing newborn immune system. We will investigate if maternal vaccines interfere with the way in which the baby responds to vaccines later in infancy and childhood, to ensure that protection is not compromised at any stage. Co-factors such as nutrition or other infections might also change the way in which mothers and infants are protected by vaccines. Hence we need to take them into consideration if we are to ensure optimal protection of vaccines in pregnancy and early life. We will also find out why women decide to receive or not to accept vaccines in different countries in order to optimise the uptake of current and new vaccines. We will endeavour to work out how vaccine safety and effectiveness can be best monitored, given the different health care systems in different countries. Addressing these implementation challenges will enable us to better understand the issues and site-preparedness in the many geographical areas and populations in which IMPRINT investigators work.

IMPRINT is a multi-disciplinary network linking investigators in Europe, Africa and Asia and can therefore address these questions comprehensively. We are uniquely set up to investigate these challenges through the diversity of expertise, availability of samples and datasets already available through our collaboration, which the members are happy to share. Through our network, we will train researchers in LMIC to take forward these important questions, and we will be the forum to provide the best evidence for the safe and efficient use of vaccines in pregnancy and newborns for the ultimate goal of lowering maternal and newborn deaths from infections.

Technical Summary

To improve maternal and neonatal health remains a focus of international investment in global health, given that Millennium Goals 4 and 5 were not achieved. 40% of all mortality in children under the age of 5 now falls into the neonatal period, with significant impact on economic development and welfare of the populations affected, primarily in LMIC. Infections are a major contributor to this burden.
There is increasing momentum to develop and implement maternal vaccines to prevent infections, in particular in LMIC, where the bulk of neonatal deaths continue to occur. In addition to its impact on the neonate, maternal vaccination offers the potential to improve maternal health and reduce stillbirths and prematurity, significant and under-appreciated problems in LMIC.
Our inter-disciplinary network will bring together national and international stakeholders representing basic science, vaccinology, social sciences, industry, public health and national and international policy makers around the opportunity of improving maternal and neonatal health by vaccination in pregnancy and the neonatal period. The applicants for the IMPRINT network have an established focus on LMIC and strong links with ODA-qualifying sites through collaborative sites in West (Gambia, Senegal, Sierra Leone), East (Malawi, Uganda) and South Africa, as well as Asia (India, China, Vietnam), providing the global context for this network.

Planned Impact

The vision of IMPRINT is the widespread implementation and uptake of safe and effective pregnancy and neonatal vaccination programmes that lead to improved long-term neonatal and maternal health, in all relevant settings.

The potential academic benefits of IMPRINT are in the advancement of our understanding of the critical aspects of immunity in pregnancy and early infancy. Our focus is on the mechanisms of protection of maternal immunization and its impact on neonatal immune ontogeny, however our work is also of relevance to other maternal and neonatal infections, for which vaccines have not yet been developed. Achievement of the IMPRINT objectives concerning acceptability, safety and effectiveness of vaccination will facilitate our understanding of how to successfully implement vaccination programmes in all settings. Maintaining the trust of both vaccinators and the general public in a range of settings requires that clear and appropriate messages are conveyed to them, including that vaccine safety is being assessed robustly and proactively. There is clear academic benefit from this work to infant and childhood vaccination in general and also to other health interventions that may be required in pregnancy. These academic benefits extend to the ongoing work of all members of the IMPRINT network, some of which currently collaborate, but many of which currently do not. This is particularly so for members in LMICs and we aim within our pilot projects and fellowships to identify, support and train candidates who will then continue to develop and work in this field and bring added future value.

Achievement of our objectives would have potential economic benefits from the prevention of infection-related deaths and disabilities in neonates, young infants and their mothers. As the bulk of global neonatal deaths and disabilities occur in LMICs the widespread implementation and uptake of effective pregnancy and neonatal vaccination programmes will be most evident in these settings. For certain candidate vaccines, such as group B streptococcus, the potential benefits extend to the young infant, the mother and with the additional benefit of reducing stillbirths and prematurity, significant and under-appreciated problems in LMIC.

The potential societal benefits anticipated include the improvement in child and family health and quality of life through avoidance of the disruption and disabilities that result from maternal and neonatal infections. These often result in additional burdens (including loss of income) for families in caring for affected patients and prevents them from receiving adequate education and ultimately reduces their contributions to society. Additionally, the lessons learned can be transferred for the benefit of other initiatives in pregnant women and young infants such as improving the uptake of other antenatal initiatives and of routine vaccinations, with resultant societal benefits.

Publications

10 25 50

 
Title Develppment of a "Speaking Book" to explain chidlhood vaccines 
Description we developed a book that has recorded messages about childhood vaccines in teh two most prevalent languages in The Gambia 
Type Of Art Film/Video/Animation 
Year Produced 2018 
Impact We are currently assessing impact on vaccine up[take and use of the book to generate better knowledge about childhood vaccines from caregivers and healthcare professionals post introduction in sentinel sites in The Gambia 
 
Title Videos about IMPRINT - our passion, global network, our innovative approach and impact on the life of mothers and infants 
Description We taped videos during our IMPRINT full network meeting (for more details, please refer to the Engagement activity section). We let two people have conversations on why they joined the network, the benefits of our network, our innovative approach and the impact on the life of mothers and infants. the half an hour interviews/conversations were cut together to approx one minute clips and are presented on our website. We aim to show our passion for our network, why it is important and why more people should join. 
Type Of Art Film/Video/Animation 
Year Produced 2018 
Impact After the meeting, we received new membership applications and feedback from the meeting participants that the videos caught perfectly the spirit of the network. 
URL http://www.imprint-network.co.uk
 
Description Vaccinating women in pregnancy is increasingly recognised as a safe and effective tool to prevent morbidity and mortality in early life of the newborn baby. Our network has established collaborations across 45 countries worldwide and set the research agenda for future steps of the research and implementation. We are now firmly recognised as authorative voices in international advisory boards, by vaccine producers and policy makers.
We continue to conduct research projects and fellowships and a lot of the outcome is yet to be measurable. The award was transferred to the London School of Hygiene and Tropical Medicine in 2018 with the PI (Prof Kampmann), hence it is not truey ended- we have a no-cost extension until May 2021. hence further reporting of output is to follow.
Exploitation Route the networks remit is to engage the vaccine community and enable them to take away ideas, projects, new collaborations so that they are able to apply for independent funds. This is precisely what is happening
Sectors Healthcare

URL http://www.imprint-network.co.uk
 
Description We have incorporated findings into a Speaking Book which explains vaccines in a LMIC settign with high illiteracy. We have used findings from our work to contribute to an APP for pregnant women
First Year Of Impact 2018
Sector Healthcare
Impact Types Societal

 
Description Advisory Board Maternal Immunisation
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact Via setting up immunisation services in antenatal clinics we have improved uptake
 
Description Membership in the Advisory Boards for WHO, BMGF and CEPI on maternal immunisation
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact Our work in vaccines and particularly within the IMPRINT network has gained visibility at high levels and we have regularly acted as advisors to the WHO, BMGF, CEPI on issues relating to the implementation of vaccines in pregnancy. This is an ongoing process- an example is our contribution to the roadmap for the development of RSV vaccines for pregnant women, cited in the URL
URL https://www.path.org/articles/roadmap-advancing-maternal-immunization-against-rsv/
 
Description The Advancing Maternal Immunization collaboration (AMI) analysis report on respiratory syncytial virus (RSV) maternal immunization
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact Beate Kampmann, our IMPRINT network PI, and Naor Bar-Zeev, our challenge 6 co-lead, joined 58 other individuals across 25 organizations in 14 countries to publish the AMI gap analysis report on respiratory syncytial virus (RSV) maternal immunization . The Advancing Maternal Immunization collaboration (AMI), coordinated by PATH in collaboration with the WHO, brings together diverse stakeholders from around the world and across immunization and maternal, newborn, and child health programs to identify a pathway to enable informed decision-making and introduction of maternal RSV vaccines, particularly in LMICs, and to provide tools to help decision-makers, implementers, researchers, and others navigate that pathway successfully.
URL https://www.path.org/resources/advancing-rsv-maternal-immunization-gap-analysis-report/
 
Description BMGF award to Dr Merryn Vossey for furtehr studeis of antibody dynamics ot measles using IMPRINT consortium samples
Amount $200,000 (USD)
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 10/2019 
End 10/2021
 
Description EDCTP award to Dr LeDoare for conduct of Group B strep clinical trial in Uganda
Amount € 6,000,000 (EUR)
Organisation European Union 
Sector Public
Country European Union (EU)
Start 08/2019 
End 08/2024
 
Description GCRF Vaccine network
Amount £2,600,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 06/2017 
End 06/2020
 
Description Pfizer-MatImms Africa project
Amount £450,000 (GBP)
Organisation Pfizer Ltd 
Sector Private
Country United Kingdom
Start 03/2017 
End 04/2022
 
Description Thrasher Foundation
Amount $25,000 (USD)
Organisation Thrasher Research Fund 
Sector Charity/Non Profit
Country United States
Start 04/2020 
End 04/2022
 
Description UKRI-Future Leaders fellowship to Dr Kirsty LeDaore, memebr of steering committee
Amount £3,000,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 06/2019 
End 06/2024
 
Description British Columbia University 
Organisation University of British Columbia
Department Department of Pediatrics
Country Canada 
Sector Academic/University 
PI Contribution provided support for field sample collections and vaccinations, plus laboratory facilities
Collaborator Contribution access to protocols
Impact publication, presentation at international meeting, visibility
Start Year 2014
 
Description Centre for Infectious Disease Research, Zambia, Dr Roma Chilengi 
Organisation Centre for Infectious Disease Research in Zambia
Country Zambia 
Sector Charity/Non Profit 
PI Contribution Roma Chilengi has been serving on our IMPRINT Executive Committee since August 2019
Collaborator Contribution Beate please add
Impact Further visibility for IMPRINT in Zambia
Start Year 2019
 
Description Collaboration with MRC/GCRF funded International Veterinary Vaccinology Network, University of Edinburgh, UK 
Organisation University of Edinburgh
Department The Roslin Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution The MRC/GCRF funded sister "Networks in Vaccine R&D" Hic-Vac, BactiVac, IntVetVacc, Validate and IMPRINT support each other by exchange of knowledge, administrative issues, the network PIs supporting network meeting by presenting their own networks and joint presentation of the networks during the BSI meeting 2017 (please refer to Engagement activities for more details).
Collaborator Contribution The MRC/GCRF funded sister "Networks in Vaccine R&D" Hic-Vac, BactiVac, IntVetVacc, Validate and IMPRINT support each other by exchange of knowledge, administrative issues, the network PIs supporting network meeting by presenting their own networks and joint presentation of the networks during the BSI meeting 2017 (please refer to Engagement activities for more details).
Impact Joint meeting attendance. Exchange of knowledge on reporting to funders and administrative matters.
Start Year 2017
 
Description Collaboration with MRC/GCRF funded network Hic-Vac, Imperial College, UK 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution the MRC/GCRF funded sister "Networks in Vaccine R&D" Hic-Vac, BactiVac, IntVetVacc, Validate and IMPRINT support each other by exchange of knowledge, administrative issues, the network PIs supporting network meeting by presenting their own networks and joint presentation of the networks during the BSI meeting 2017 (please refer to Engagement activities for more details).
Collaborator Contribution the MRC/GCRF funded sister "Networks in Vaccine R&D" Hic-Vac, BactiVac, IntVetVacc, Validate and IMPRINT support each other by exchange of knowledge, administrative issues, the network PIs supporting network meeting by presenting their own networks and joint presentation of the networks during the BSI meeting 2017 (please refer to Engagement activities for more details).
Impact Joint meetings and exchange of knowledge on reporting and administrative issues.
Start Year 2017
 
Description Collaboration with the MRC/GCRF funded network BactiVac, University of Birmingham, UK 
Organisation University of Birmingham
Country United Kingdom 
Sector Academic/University 
PI Contribution The MRC/GCRF funded sister "Networks in Vaccine R&D" Hic-Vac, BactiVac, IntVetVacc, Validate and IMPRINT support each other by exchange of knowledge, administrative issues, the network PIs supporting network meeting by presenting their own networks and joint presentation of the networks during the BSI meeting 2017 (please refer to Engagement activities for more details).
Collaborator Contribution The MRC/GCRF funded sister "Networks in Vaccine R&D" Hic-Vac, BactiVac, IntVetVacc, Validate and IMPRINT support each other by exchange of knowledge, administrative issues, the network PIs supporting network meeting by presenting their own networks and joint presentation of the networks during the BSI meeting 2017 (please refer to Engagement activities for more details).
Impact Joint meeting attendance. Exchange of knowledge on reporting to funders and administrative matters.
Start Year 2017
 
Description Collaboration with the MRC/GCRF funded network Validate , University of Oxford, UK 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution The MRC/GCRF funded sister "Networks in Vaccine R&D" Hic-Vac, BactiVac, IntVetVacc, Validate and IMPRINT support each other by exchange of knowledge, administrative issues, the network PIs supporting network meeting by presenting their own networks and joint presentation of the networks during the BSI meeting 2017 (please refer to Engagement activities for more details).
Collaborator Contribution The MRC/GCRF funded sister "Networks in Vaccine R&D" Hic-Vac, BactiVac, IntVetVacc, Validate and IMPRINT support each other by exchange of knowledge, administrative issues, the network PIs supporting network meeting by presenting their own networks and joint presentation of the networks during the BSI meeting 2017 (please refer to Engagement activities for more details).
Impact Joint meeting attendance, exchange of knowledge on reporting to funders and administrative matters.
Start Year 2017
 
Description Imperial College London, UK; Dr Holder 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Dr Holder is member of our network Steering Committee
Collaborator Contribution Dr. Beth Holder is a Lecturer in Maternal and Fetal Health in the Institute of Reproductive Biology (IRDB) and our IMPRINT challenge 1 "Mechanism of production and transfer of maternal antibody via the placenta and breast milk" co-lead. She supports the network with her expertise.
Impact IMPRINT joint events (e.g. London Midwifery Festival, please refer to the section Engagement Activities) and publications. MatImms App for pregnant women (please refer to Engagement Activities).
Start Year 2017
 
Description Johns Hopkins Bloomberg School of Public Health, USA; Dr Bar-Zeev 
Organisation Johns Hopkins University
Department Johns Hopkins Bloomberg School of Public Health
Country United States 
Sector Academic/University 
PI Contribution Naor Bar-Zeev served as an IMPRINT Steering Committee Member from the start of IMPRINT until July 2019.
Collaborator Contribution Dr Naor Bar-Zeev is a pediatric infectious diseases physician and statistical epidemiologist. His research interest is in understanding how to maximise the benefit of existing and future vaccines in low-resourced high mortality settings, how best to protect vulnerable groups like newborns and pregnant women and how to optimise methods to evaluate vaccine impact and effectiveness. He is part of our IMPRINT Steering Committee and challenge 6 "Development of comparable methodologies for assessing efficacy in clinical trials" co-lead.
Impact Joint IMPRINT events.
Start Year 2017
 
Description Levy Lab 
Organisation Boston Children's Hospital
Department Levy Laboratory
Country United States 
Sector Hospitals 
PI Contribution set up of systems vaccinology research for studies of EPI vaccines
Collaborator Contribution bioinformatics support
Impact several publications and a grant submission to the nIH
Start Year 2014
 
Description London School of Hygiene and Tropical Medicine and the Vaccine Confidence Project, UK, Prof. Larson 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Heidi Larson is a member of our IMPRINT Steering Committee.
Collaborator Contribution Prof. Heidi J. Larson is an anthropologist and Director of The Vaccine Confidence Project™ (VCP); Professor of Anthropology, Risk and Decision Science, Dept. Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine; Clinical Professor, Institute of Health Metrics & Evaluation, University of Washington; and Chatham House Centre on Global Health Security Fellow. She is a member of our IMPRINT Steering Committee and one of our challenge 4 "Vaccine acceptancy and preparedness for maternal immunisation, including in emergencies" co-leads. IMPRINT is featured as a partner on the vaccine confidence.org website (please refer to Engagement activities for more details).
Impact Joint IMPRINT events.
Start Year 2017
 
Description National Health Services, UK; Dr Mehring-Le Doare 
Organisation National Health Service
Country United Kingdom 
Sector Hospitals 
PI Contribution Dr Kirsty Mehring-le Doare is one of our IMPRINT Steering Committee members.
Collaborator Contribution Dr Mehring is consultant in Paediatric Infectious Diseases and Immunology, CSAC Training Advisor (PIID). She also functions as one of our IMPRINT Steering Committee members and co-lead of our challenge "Mechanism of production and transfer of maternal antibody via the placenta and breast milk".
Impact Joint IMPRINT events and publications.
Start Year 2017
 
Description PATH 
Organisation PATH
Country Global 
Sector Charity/Non Profit 
PI Contribution Path vaccine roadmap work
Collaborator Contribution scientific advice
Impact funding
Start Year 2016
 
Description UCAD 
Organisation University Cheikh Anta Diop de Dakar
Country Senegal 
Sector Academic/University 
PI Contribution Professor Mboup and Professor Gaye are partners in our West African Global Health Research initiative and a number of members of their respective departments are now involved in our research
Collaborator Contribution exchange of ideas and potential for join grant applications
Impact scientific workshops
Start Year 2016
 
Description University of Liverpool, Prof. French 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution Neil French is member of our IMPRINT Steering Committee
Collaborator Contribution Neil French is Professor of Infectious Diseases and Global Health and Hon Consultant Infectious Diseases Royal Liverpool & Broadgreen University Hospitals Trust. He is a member of our IMPRINT Steering Committee and challenge 6 "Development of comparable methodologies for assessing efficacy in clinical trials" co-lead.
Impact Joint IMPRINT events and publications.
Start Year 2017
 
Description University of Oxford, UK; Dr Drakesmith 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Alexander Drakesmith is member of our IMPRINT Steering Committee
Collaborator Contribution Dr Drakesmith´s lab is at the Weatherall Institute of Molecular of Medicine where he studies the role of iron in infectious diseases and the immune response. He is member of our IMPRINT Steering Committee and challenge 3 "Impact of globally important co-factors on maternal and neonatal immunity" co-lead.
Impact Joint IMPRINT events.
Start Year 2017
 
Description University of the Witwatersrand, South Africa; Dr Clare Cutland 
Organisation University of the Witwatersrand
Department Respiratory And Meningeal Pathogens Unit
Country South Africa 
Sector Academic/University 
PI Contribution Clare Cutland is one of our network Executive Committee members.
Collaborator Contribution Dr. Clare Cutland is the Deputy Director at the Respiratory and Meningeal Pathogens Research Unit (RMPRU) based at Chris Hani Baragwanath Academic Hospital (CHBAH), Soweto, South Africa. She has been a sub-investigator/ senior doctor on numerous phase I, II and III paediatric vaccine trials and principal investigator on a phase II paediatric measles vaccine trial and a phase III quadrivalent influenza vaccine trial in children. She is part of our IMPRINT Steering committee group and co-lead of our challenge "Vaccine Safety and Monitorgin in LMIC".
Impact Joint events related to IMPRINT. Publications are currently in preparation.
Start Year 2017
 
Description At Radcliffe Department of Medicine, University of Oxford 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact IMPRINT Pump Priming awardee Dr Andrew Armitage will give a presentation on 23 March 2020 to all members of Radcliffe Department of Medicine, University of Oxford. Non-clinical and clinician scientists including graduate students, postdocs, clinicians and Principal Investigators. The presentation is titled: "Ins and Outs of Iron in Infants"
Year(s) Of Engagement Activity 2020
 
Description At UVRI Uganda - Simon Kimuda 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact On 20-22 February, IMPRINT pump priming awardee Simon Kimuda gave a presentation at UVRI in Entebbe, Uganda titled: "TB vaccine research at UVRI".
Year(s) Of Engagement Activity 2019
URL https://twitter.com/muiiplus/status/1098531500092465152?s=21
 
Description At Uganda's National Tuberculosis and Leprosy Programem - Simon Kimuda 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact On 4 October 2019, IMPRINT pump priming awardee Simon Kimuda gave a presentation on TB vaccine research studies at Uganda's National Tuberculosis and Leprosy Programme in Kampala. He presented on his IMPRINT funded study investigating factors influencing BCG-mediated in vitro growth inhibition in Ugandan infants.
Year(s) Of Engagement Activity 2019
 
Description Blog feature MatIMMS project, Patient Experience Research Center Imperial College London 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The MatImms project consists of a multi-disciplinary research team of midwives, doctors and scientists that investigates vaccination in pregnancy. The project is led by Prof. Beate Kampmann. MatImms encourages vaccination in pregnancy to protect newborn babies from preventable infections. In the laboratory, MatImms studies the impact of vaccines on immunity in mothers and babies. In order to connect with pregnant women, the MatImms Smartphone App has been developed to improve vaccine information available, enabling pregnant women and their support networks to make informed choices. Our challenge 1 co-lead Beth Holder co-developed the App and its contents. IMPRINT is mentioned on the blog news.
Year(s) Of Engagement Activity 2019
URL http://wwwf.imperial.ac.uk/blog/perc/2019/02/11/case-study-15-matimms-involve-women-in-research-addr...
 
Description British Society for Immunology (BSI) Meeting, UK 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Our IMPRINT network manager, Dr Claudia Schacht, together with our sister Network Managers from the VALIDATE Network (Vaccine development for complex intracellular neglected pathogens), IntVetVac (the International Veterinary Vaccinology Network), HIC-Vac (The Human Challenge Model Network) and BactiVac (the Bacterial Vaccines Network) joined forces during the British Society for Immunology (BSI) meeting in Brighton to introduce the networks, attracts new members and talk about the start or our first rounds of funding calls.
Year(s) Of Engagement Activity 2017
URL https://www.immunology.org/events/bsi-congress
 
Description Community sensitisation events 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Participants in your research and patient groups
Results and Impact The community sensitisation events are regularly conducted to inform past, present and future participants in our research on the results of previous studies and upcoming new research studies and clinical trials. They serve as a link to the community decision makers and are well supported by community members and MRC researchers.

Increased participation in clincial trials and ongoign research
Year(s) Of Engagement Activity 2010,2011,2012,2013,2014
 
Description European Society for Pediatric Infectious Diseases (ESPID) meeting cum IMPRINT Research Session, Sweden 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact At the European Society for Pediatric Infectious Diseases meeting in Malmö, Sweden, our network Co-PI Dr Chrissie Jones organized a research session for IMPRINT members and people interested in our network. We aimed to meet with IMPRINT network members attending the conference as well as attracting new members. In addition, Dr Chrissie Jones was also available at the "Meet the Professor" Session and present "a randomized controlled trial comparing two pertussis-containing vaccines in pregnancy and vaccine responses in UK mothers and their infants (Immunizing Mums Against Pertussis, IMAP2).
Year(s) Of Engagement Activity 2018
 
Description IMPRINT Full Network Meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact We held our first full network meeting in Sept 2018 in Kingston upon Thames with a total of 87 participants. At that time, the network was running for 14 months and had a total of 200 members. Travel funds for young scientists, postdocs as well as grant holders were provided. 30% of the participants came from LMIC, 70% from HIC and from a total of 22 different countries. During the meeting, we not only had scientific talks by our pump priming and fellowship holders on their IMPRINT sponsored projects, but also from our GCRF sister network PIs and stakeholders from policy (Ghana Standards Authority and WHO), as well as the Group Strep B support group.. We also had an industry panel discussion with representatives from Pfizer, GSK and Sanofi Pasteur. We offered workshops on the topic of Patient and Public Involvement and grant writing as media training. A speed dating session for networking fostered the interaction between the participants.
Additionally, we supported the career of our IMPRINT sponsored fellows by recording video interviews about their research and career which we will display at the IMPRINT website and provide to the fellows.
We also recorded videos and interviews with our network members on our passion for research, our network of members, our innovational approach and impact. All videos can be seen on our website.
Year(s) Of Engagement Activity 2018
URL http://www.imprint-network.co.uk
 
Description IMPRINT Session & Network Meeting at INMIS 2019 in Vancouver 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact On 17 September 2019, IMPRINT held a session and network meeting in conjunction with the 5th International Maternal and Neonatal Immunisation symposium (INMIS) in Vancouver, Canada. INMIS takes place bi-annually and is the world leading conference in the field of maternal and neonatal immunisation and as such the most important conference for IMPRINT to reach our main target audience, namely researchers, industry partners, funders and other stakeholders in our field.

IMPRINT was one of the sponsors for INMIS contributing travel funds for IMPRINT members and the IMPRINT Steering Group. The session took place directly after INMIS and was advertised to all INMIS attendees as well as the whole IMPRINT network. In total, the session was attended by over 70 people.

The session consisted of presentations by all IMPRINT funded Pump Priming projects and IMPRINT Fellows, as well a select presentations by one of our newly funded Public Engagement projects. In addition to the research and engagement projects, The Vaccine Confidence Project presented on its measures to monitore vaccine confidence across media & social media, utilizing machine learning, digital analytics and confidence mapping. The project is co-funded by IMPRINT.

Impact: The session offered excellent networking opportunity for all IMPRINT awardees to form future research collaborations. Both industry representatives (e. g from GSK) and representatives from the Bill & Melinda Gates Foundation attended the meeting fostering dialogue about potential collaborations on network level as well as sustainability for the IMPRINT network. In addition, the session led to a spike in membership applications. Due to our presence at INMIS, approx. 20 new members joined the network.
Year(s) Of Engagement Activity 2019
URL http://www.inmis.org
 
Description IMPRINT kickoff at INMIS 2017, Brussels 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact IMPRINT official kickoff meeting during 4th International Neonatal & Maternal Immunization Symposium in Brussels in Sept 2017. The network was introduced by the network PIs, Prof. Beate Kampmann, Dr Chrissie Jones, the network manager Dr Claudia Schacht. Presentations were also given by members of the IMPRINT Steering Committee (Heidi Larson, Clare Cutland, Sonali Kochhar). The meeting attracted the first round of membership applicants to our network.
A Steering committee kickoff meeting was held with 8 out of 13 members.
A stakeholder meeting with participants from the Bill and Melinda Gates Foundation, PATH, GSK, Minervax, NIAID, Pfizer and UNICEF was held.
Year(s) Of Engagement Activity 2017
URL http://www.inmis.org/index.php?p=previousInmis
 
Description INMIS media interveiw 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact as part of the International Symposium for neonatal and maternal immunisations hick I organised in The Gambia I gave a television interview to the national media which was broadcasted on the same day
Year(s) Of Engagement Activity 2015
 
Description Immunisation Reminder App - Dr Dan Kajungu 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Smart Phone Application to remind mothers and caretakers about scheduled immunisations
Year(s) Of Engagement Activity 2019
 
Description Impact Science Report 2018 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact IMPRINT was featured in the latest Impact Science Report. Our network PIs Beate Kampmann and Chrissie Jones talked about the "value of vaccination in pregnancy". They discussed our innovative and game-changing network activities as well as the network´s long-term global impact. Our IMPRINT fellow Alansana Darboe is also featured and shares how the IMPRINT fellowship will foster his research career. The article aimed at increasing our visibility and attract new members.
Year(s) Of Engagement Activity 2018
URL http://impact.pub/December2018-2digitaledition/
 
Description Introducing the importance of biomedical sciences in the development of The Gambian health sector - Dr Alansana Darboe 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact On 6-9 January, IMPRINT Fellow Dr Alansana Darboe gave a workshop to Gambian University students titled "Introduction of biomedical scineces to The Gambia university students"
Year(s) Of Engagement Activity 2020
 
Description Introduction of IMPRINT at the Department of Public Health, Erasmus MC, University Medical Center, Rotterdam 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Sonali Kochhar, one of our network steering committee members presented on maternal immunization to the Department of Public Health, Erasmus MC, University Medical Center, Rotterdam, The Netherlands on 5th Sept 2018 - it was attended by Public Health, Infectious Disease,  Vaccine and clinical research experts at Erasmus MC, University Medical Center, Rotterdam. There was a lot of interest in the IMPRINT network as the attendees hadn´t heard of it. The aim was to increase our network and attract new members.
Year(s) Of Engagement Activity 2018
 
Description Keynote at RIVM Vaccine Preventable Diseases research day - Dr Merryn Voysey 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact On 6 February 2020, IMPRINT pump priming awardee Dr Merryn Voysey was invited to give a keynote speech at the RIVM Vaccine Preventable Diseases research day in the Netherlands.
Year(s) Of Engagement Activity 2020
 
Description King's College London, Institute of Psychiatry, Psychology & Neuroscience - Dr Sonali Kochhar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact On 7 February 2019, IMPRINT Steering Group member Dr Sonali Kochar gave a presentation at King's College London, Institute of Psychiatry, Psychology & Neuroscience titled: Maternal Immunization Clinical Research in Low and Middle Income Countries: Study Design, Regulatory, Ethical and Safety Considerations.
Year(s) Of Engagement Activity 2019
URL https://www.kcl.ac.uk/events/maternal-immunization-clinical-research-in-low-and-middle-income-countr...
 
Description London Maternity and Midwifery Festival 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact IMPRINT was promoted at the first London Maternity & Midwifery Festival that took place on February 13th 2018 with over 1600 participants. This national professional festival, with leadership speakers and exhibitions, is to be held annually to highlight developments in maternity and midwifery across the South East of the United Kingdom.

Our IMPRINT network member Beth Holder and a team from London School of Hygiene and Tropical Medicine attended the event to promote MatImms, a free Smartphone App designed by leading experts of paediatric infectious diseases at London School of Hygiene and Tropical Medicine that aims to improve vaccine information available to pregnant women, enabling them to make informed choices and encourages vaccination in pregnancy to protect newborn babies from preventable infections. MatImms collaborate with pregnant women alongside academic, clinical and policy partners such as Public Health England and antenatal services, in the UK and globally through the Centre for International Child Health.
Matimms is led by Professor Beate Kampmann.
We aimed to attract midwifes to our network and spark interest of the general public.
Year(s) Of Engagement Activity 2018
URL http://www.maternityandmidwifery.co.uk/events/london-2018/
 
Description Meeting with UNEPI, Ministry of Health - Dr Dan Kajungu 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact IMPRINT Fellow Dr Dan Kajungu met with the UNEPI team of the Ugandan Ministry of Health on 10 November 2019 to introduce the project activities of his fellowship to stakeholders
Year(s) Of Engagement Activity 2019
 
Description Midwifery conference 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Open Day and midwifery conference at earls Court London, large exhibition of activities, promotion of our App for maternal immunisation
Year(s) Of Engagement Activity 2018
 
Description Oral abstract presentation at FIS 2019: Federation of Infection Societies Conference - Dr Merryn Voysey 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact On 11 November 2019, IMPRINT pump priming awardee Dr Merryn Voysey gave an oral abstract presentation on her research at the Federation of Infection Societies Conference 2019 in Edinburgh.
Year(s) Of Engagement Activity 2019
 
Description Orientation and Training of research assistants, interviewers, women leaders, actors and crew members; Public Engagement Project Ugochukwu Madubueze 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact On 26 October 2019, IMPRINT public engagement awardee Ugochukwu Madubueze held a workshop for her project, training 31 research assistants/ interviewers and 30 community celebrities/role models
Year(s) Of Engagement Activity 2019
 
Description Partner: IMPRINT and the Vaccine Confidence Project 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Prof Heidi Larson, one of our network challenge leads also holds the position of the director of the Vaccine Confidence Project, based at the London School of Hygiene and Tropical Medicine. The purpose of the project is to monitor public confidence in immunisation programmes by building an information surveillance system for early detection of public concerns around vaccines. IMPRINT is featured as the Vaccine Confidence Partner on their website. We plan to open a call in the near future about patient and public engagement in vaccination, and the Vaccine Confidence project display gives us more visibility.
Year(s) Of Engagement Activity 2018,2019
URL http://www.vaccineconfidence.org
 
Description Poster Presentation at INMIS 2019 - Alansana Darboe 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Our IMPRINT Fellow Dr Alansana Darboe had a poster presentation at the International Neonatal and Maternal Immunization Symposia (INMIS) on 11 September 2019 in Vancouver, Canada. His presentation was titled: Understanding the interaction between maternal anitbodies & monocytes
Year(s) Of Engagement Activity 2019
 
Description Poster Presentation at INMIS 2019 - Merryn Voysey 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Our IMPRINT pump priming awardee Dr Merryn Voysey gave a poster presentation at the International Neonatal and Maternal Immunization Symposia (INMIS) on 15 September 2019 in Vancouver, Canada.
Year(s) Of Engagement Activity 2019
 
Description Poster Presentation at INMIS 2019 - Shadia Khandaker 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact On 15 September 2019, IMPRINT pump priming awardee gave a poster presentation at INMIS 2019 titled: "Humanised FcRn mouse model: a novel tool for preclinical testing of vaccine induced immune correlates and maternofetal transfer of humoral immunity"
Year(s) Of Engagement Activity 2019
URL http://www.inmis.org/
 
Description Poster Presentation at The annual meeting of the 'Centre for Global Vaccine Research', University of Liverpool 2019 - Shadia Khandaker 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact On 01 November 2018, IMPRINT Fellow Dr Shadia Khandaker gave a presentation at the the annual meeting of the 'Centre for Global Vaccine Research', University of Liverpool. The presentation was titled: Understanding GBS protective immunity in high- vs. low- GBS prevalence settings exploiting a novel humanised mouse model
Year(s) Of Engagement Activity 2018
 
Description Presentation at The annual meeting of the 'Centre for Global Vaccine Research', University of Liverpool 2019 - Shadia Khandaker 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact On 24 October 2019, IMPRINT Fellow Dr Shadia Khandaker gave a presentation at the the annual meeting of the 'Centre for Global Vaccine Research', University of Liverpool. The presentation was titled: Towards the understanding of anti-Group B Streptococcus (GBS) protective immunity: characterisation of maternal sera in high- vs. low- GBS prevalence countries
Year(s) Of Engagement Activity 2019
 
Description Presentation in Dar es salaam, Tanzania - Simon Kimuda 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact On 27-28 November 2019, IMPRINT pump priming awardee Simon Kimuda gave a presentation at priMe (A multi-centre phase III double-blind, randomised, controlled study evaluating the efficacy and safety of VPM1002 in comparison to BCG) investigators meeting in Dar es salaam, Tanzania describing recruitment and retention strategies learned from our IMPRINT funded study. The presentation was titled: "Recruitment and retention strategies: Lessons learned from a pilot study at UVRI"
Year(s) Of Engagement Activity 2019
URL https://www.prime-vaccine.eu/news-press/?we_objectID=188
 
Description Project website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact With our website, we aim to build a sustainable network of stakeholders from basic science, immunology, vaccinology, social sciences, industry, public health and national and international policy makers, to tackle the challenges in the best use of vaccines in pregnancy and in newborns, and in the long term to improve maternal and newborn health.
The website helps us to foster capacity for research and innovation within the UK and in developing countries and set up new collaborations.

In February 2020, the released a complete redesign of the website, including a separate events page to announce and advertise IMPRINT network meetings and other events supported by IMPRINT.
Year(s) Of Engagement Activity 2017,2018,2019,2020
URL http://www.imprint-network.co.uk
 
Description RE:Action 2017, Magazin of the University of Southampton 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Chrissie Jones and IMPRINT were featured in the The RE:Action Magazine of the University of Southampton, Re:action is the University of Southampton's bi-annual Research and Enterprise newsletter offering insight into public policy related research conducted at the University as well as public engagement and business activities. the article aimed to increase our visibility and attract potential new members to the network.
Year(s) Of Engagement Activity 2017
URL https://e.issuu.com/anonymous-embed.html?u=university_of_southampton&d=web_version_reaction_magazine...
 
Description Regular IMPRINT newsletter for members 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact We regularly send out an email newsletter to all IMPRINT members to keep them engaged with the network and informed about IMPRINT activities, such as new calls for proposals (e. g. in 2019/2020 our Public Engagement, Pump Priming and Industry Placement), travel bursaries (e. g. for members from LMIC to attend vaccinology courses), relevant publications, IMPRINT network meetings, etc.

The newsletter is a central communication tool for the network and has helped us attract around 5-20 applications for each call we issue. As of 8 March 2020, we reach all our 281 members with the newsletter. We send out newsletters between 1-4 times per month.
Year(s) Of Engagement Activity 2017,2018,2019,2020
 
Description Regular appearances on BBC, BBC World Service, BBC radio for vaccine related questions throughout the last 12 months 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact I am a regular guest on various media channels, Victoria Derbyshire program, mainly BBC- there are too many to list individually. I have spoken about measles, HPV, corona virus and vaccine confidence, including in pregnant women.
Year(s) Of Engagement Activity 2019,2020
URL https://www.bbc.co.uk/news/health-47787908
 
Description Stakeholders meeting on Maternal Interventions Vigilance: Safety Monitoring and Surveillance in Vaccine and other Research Settings, WHO Geneva 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Sonali Kochhar introduced IMPRINT during the stakeholder meeting on Maternal Interventions Vigilance at the WHO in Geneva.
Year(s) Of Engagement Activity 2017
URL http://apps.who.int/medicinedocs/documents/s23416en/s23416en.pdf
 
Description TB vaccine research at the Uganda Virus Research Institute (UVRI) - Simon Kimuda 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact On 12 February 2020, IMPRINT pump priming awardee Simon Kimuda gave a presentation on TB vaccine research studies at UVRI. He presented updates from his IMPRINT funded study investigating factors influencing BCG-mediated in vitro growth inhibition in Ugandan infants.
Year(s) Of Engagement Activity 2020
URL https://twitter.com/muiiplus/status/1227217108901224448?s=21
 
Description The Value of vacciens to soceities- a presentation in Valencia, Spain on invitation of the British Council 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact On invitation of the British Council, I presented on the topic of Value of Vaccines in society- do we really appreciate them? the session was held in the museum of Sciences in Valencia, Spain and is available on youtube. This was part of a regular open forum for general public organsied by the British Council in Spain.

https://www.youtube.com/watch?v=oiBam59ErFg
Year(s) Of Engagement Activity 2020
URL https://www.youtube.com/watch?v=oiBam59ErFg
 
Description Twitter Account 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Our Twitter account engages mainly scientists and the general public. We tweet about the topic of vaccination in general, retweet worldwide funding opportunities and engage with other GRCF funded networks on the topic of immunization. We also tweet about our own funding options. We attracted over 320 followers since Sept 2017 (up from 200 since the 2019 report).
Year(s) Of Engagement Activity 2017,2018,2019,2020
URL https://twitter.com/imprint_network
 
Description Workshop cum Expert Review Meeting on Maternal Immunization, New Delhi 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Beate Kampmann, our network PI, Beth Holder, our challenge 1 co-lead and Sonali Kochhar, our challenge 5 co-lead, introduced IMPRINT at the "Workshop cum Expert Review Meeting on Maternal Immunization" September 10th in New Delhi, organized by the PRERNA Platform, KEM Hospital Research Centre Pune, with support from WHO-TDR Fellowship in Clinical Research and Development and the Bill and Melinda Gates Foundation. The meeting was attended by global and Indian public health, infectious disease, vaccine and clinical experts.

The objectives of the meeting were to:

- foster discussion among national and global leaders in maternal immunization to identify and prioritise research areas in maternal immunization in India
- initiate research proposals
- development in maternal immunization in collaboration with national and international partners
Year(s) Of Engagement Activity 2018
URL http://www.prernaindia.in/images/mi.pdf