IMPRINT: IMmunising PRegnant women and INfants neTwork

Lead Research Organisation: Imperial College London
Department Name: Dept of Medicine

Abstract

Far too many newborns continue to die in early life, particularly in low-and middle income countries (LMIC). Many die from infections, some of which could be prevented. During the late stages of pregnancy, antibody is transferred across the placenta from mother to child, providing protection to the infant in the early weeks of life. However, if the mother has insufficient protection against certain infections, the infant will also not be protected.

Vaccinating women in pregnancy can enhance the level of antibody in the mother, thereby protecting the mother, and increasing the amount of antibody transferred across the placenta - protecting the infant from birth too. This concept has already been successfully established for the prevention of tetanus, influenza and pertussis (whooping cough). Many investigators and stakeholders are interested in using this strategy to protect infants from other serious infections, for example group B streptococcus or respiratory syncytial virus (RSV), and vaccines against these infections are in development. Some fundamental gaps in our understanding remain about the immune response to vaccines in pregnancy and in newborn infants which are essential for us to address in order to accelerate development of new vaccines. It is also very important that the scientific community tackles how best to implement such vaccine programmes in both high-income countries and LMIC.

Our unique inter-disciplinary network represents stakeholders from basic science, immunology, vaccinology, social sciences, industry, public health and national and international policy makers who have come together in order to tackle the key challenges in the best use of vaccines in pregnancy and in newborns, and in the long term, improve maternal and newborn health.

Specifically, the IMPRINT network will implement collaborative research projects to answer fundamental biological questions about antibody transfer of antibody across the placenta, how to induce the "best" antibody, and its effect on the maturing newborn immune system. We will investigate if maternal vaccines interfere with the way in which the baby responds to vaccines later in infancy and childhood, to ensure that protection is not compromised at any stage. Co-factors such as nutrition or other infections might also change the way in which mothers and infants are protected by vaccines. Hence we need to take them into consideration if we are to ensure optimal protection of vaccines in pregnancy and early life. We will also find out why women decide to receive or not to accept vaccines in different countries in order to optimise the uptake of current and new vaccines. We will endeavour to work out how vaccine safety and effectiveness can be best monitored, given the different health care systems in different countries. Addressing these implementation challenges will enable us to better understand the issues and site-preparedness in the many geographical areas and populations in which IMPRINT investigators work.

IMPRINT is a multi-disciplinary network linking investigators in Europe, Africa and Asia and can therefore address these questions comprehensively. We are uniquely set up to investigate these challenges through the diversity of expertise, availability of samples and datasets already available through our collaboration, which the members are happy to share. Through our network, we will train researchers in LMIC to take forward these important questions, and we will be the forum to provide the best evidence for the safe and efficient use of vaccines in pregnancy and newborns for the ultimate goal of lowering maternal and newborn deaths from infections.

Technical Summary

To improve maternal and neonatal health remains a focus of international investment in global health, given that Millennium Goals 4 and 5 were not achieved. 40% of all mortality in children under the age of 5 now falls into the neonatal period, with significant impact on economic development and welfare of the populations affected, primarily in LMIC. Infections are a major contributor to this burden.
There is increasing momentum to develop and implement maternal vaccines to prevent infections, in particular in LMIC, where the bulk of neonatal deaths continue to occur. In addition to its impact on the neonate, maternal vaccination offers the potential to improve maternal health and reduce stillbirths and prematurity, significant and under-appreciated problems in LMIC.
Our inter-disciplinary network will bring together national and international stakeholders representing basic science, vaccinology, social sciences, industry, public health and national and international policy makers around the opportunity of improving maternal and neonatal health by vaccination in pregnancy and the neonatal period. The applicants for the IMPRINT network have an established focus on LMIC and strong links with ODA-qualifying sites through collaborative sites in West (Gambia, Senegal, Sierra Leone), East (Malawi, Uganda) and South Africa, as well as Asia (India, China, Vietnam), providing the global context for this network.

Planned Impact

The vision of IMPRINT is the widespread implementation and uptake of safe and effective pregnancy and neonatal vaccination programmes that lead to improved long-term neonatal and maternal health, in all relevant settings.

The potential academic benefits of IMPRINT are in the advancement of our understanding of the critical aspects of immunity in pregnancy and early infancy. Our focus is on the mechanisms of protection of maternal immunization and its impact on neonatal immune ontogeny, however our work is also of relevance to other maternal and neonatal infections, for which vaccines have not yet been developed. Achievement of the IMPRINT objectives concerning acceptability, safety and effectiveness of vaccination will facilitate our understanding of how to successfully implement vaccination programmes in all settings. Maintaining the trust of both vaccinators and the general public in a range of settings requires that clear and appropriate messages are conveyed to them, including that vaccine safety is being assessed robustly and proactively. There is clear academic benefit from this work to infant and childhood vaccination in general and also to other health interventions that may be required in pregnancy. These academic benefits extend to the ongoing work of all members of the IMPRINT network, some of which currently collaborate, but many of which currently do not. This is particularly so for members in LMICs and we aim within our pilot projects and fellowships to identify, support and train candidates who will then continue to develop and work in this field and bring added future value.

Achievement of our objectives would have potential economic benefits from the prevention of infection-related deaths and disabilities in neonates, young infants and their mothers. As the bulk of global neonatal deaths and disabilities occur in LMICs the widespread implementation and uptake of effective pregnancy and neonatal vaccination programmes will be most evident in these settings. For certain candidate vaccines, such as group B streptococcus, the potential benefits extend to the young infant, the mother and with the additional benefit of reducing stillbirths and prematurity, significant and under-appreciated problems in LMIC.

The potential societal benefits anticipated include the improvement in child and family health and quality of life through avoidance of the disruption and disabilities that result from maternal and neonatal infections. These often result in additional burdens (including loss of income) for families in caring for affected patients and prevents them from receiving adequate education and ultimately reduces their contributions to society. Additionally, the lessons learned can be transferred for the benefit of other initiatives in pregnant women and young infants such as improving the uptake of other antenatal initiatives and of routine vaccinations, with resultant societal benefits.

Publications

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Le Doare K (2017) Intrapartum Antibiotic Chemoprophylaxis Policies for the Prevention of Group B Streptococcal Disease Worldwide: Systematic Review. in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

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Saso A (2017) Vaccine responses in newborns. in Seminars in immunopathology

 
Title Develppment of a "Speaking Book" to explain chidlhood vaccines 
Description we developed a book that has recorded messages about childhood vaccines in teh two most prevalent languages in The Gambia 
Type Of Art Film/Video/Animation 
Year Produced 2018 
Impact We are currently assessing impact on vaccine up[take and use of the book to generate better knowledge about childhood vaccines from caregivers and healthcare professionals post introduction in sentinel sites in The Gambia 
 
Title Videos about IMPRINT - our passion, global network, our innovative approach and impact on the life of mothers and infants 
Description We taped videos during our IMPRINT full network meeting (for more details, please refer to the Engagement activity section). We let two people have conversations on why they joined the network, the benefits of our network, our innovative approach and the impact on the life of mothers and infants. the half an hour interviews/conversations were cut together to approx one minute clips and are presented on our website. We aim to show our passion for our network, why it is important and why more people should join. 
Type Of Art Film/Video/Animation 
Year Produced 2018 
Impact After the meeting, we received new membership applications and feedback from the meeting participants that the videos caught perfectly the spirit of the network. 
URL http://www.imprint-network.co.uk
 
Description Advisory Board Maternal Immunisation
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact Via setting up immunisation services in antenatal clinics we have improved uptake
 
Description The Advancing Maternal Immunization collaboration (AMI) analysis report on respiratory syncytial virus (RSV) maternal immunization
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact Beate Kampmann, our IMPRINT network PI, and Naor Bar-Zeev, our challenge 6 co-lead, joined 58 other individuals across 25 organizations in 14 countries to publish the AMI gap analysis report on respiratory syncytial virus (RSV) maternal immunization . The Advancing Maternal Immunization collaboration (AMI), coordinated by PATH in collaboration with the WHO, brings together diverse stakeholders from around the world and across immunization and maternal, newborn, and child health programs to identify a pathway to enable informed decision-making and introduction of maternal RSV vaccines, particularly in LMICs, and to provide tools to help decision-makers, implementers, researchers, and others navigate that pathway successfully.
URL https://www.path.org/resources/advancing-rsv-maternal-immunization-gap-analysis-report/
 
Description GCRF Vaccine network
Amount £2,600,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 06/2017 
End 06/2020
 
Description Pfizer-MatImms Africa project
Amount £450,000 (GBP)
Organisation Pfizer Ltd 
Sector Private
Country United Kingdom
Start 03/2017 
End 10/2019
 
Description British Columbia University 
Organisation University of British Columbia
Department Department of Pediatrics
Country Canada 
Sector Academic/University 
PI Contribution provided support for field sample collections and vaccinations, plus laboratory facilities
Collaborator Contribution access to protocols
Impact publication, presentation at international meeting, visibility
Start Year 2014
 
Description Collaboration with MRC/GCRF funded International Veterinary Vaccinology Network, University of Edinburgh, UK 
Organisation University of Edinburgh
Department The Roslin Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution The MRC/GCRF funded sister "Networks in Vaccine R&D" Hic-Vac, BactiVac, IntVetVacc, Validate and IMPRINT support each other by exchange of knowledge, administrative issues, the network PIs supporting network meeting by presenting their own networks and joint presentation of the networks during the BSI meeting 2017 (please refer to Engagement activities for more details).
Collaborator Contribution The MRC/GCRF funded sister "Networks in Vaccine R&D" Hic-Vac, BactiVac, IntVetVacc, Validate and IMPRINT support each other by exchange of knowledge, administrative issues, the network PIs supporting network meeting by presenting their own networks and joint presentation of the networks during the BSI meeting 2017 (please refer to Engagement activities for more details).
Impact Joint meeting attendance. Exchange of knowledge on reporting to funders and administrative matters.
Start Year 2017
 
Description Collaboration with MRC/GCRF funded network Hic-Vac, Imperial College, UK 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution the MRC/GCRF funded sister "Networks in Vaccine R&D" Hic-Vac, BactiVac, IntVetVacc, Validate and IMPRINT support each other by exchange of knowledge, administrative issues, the network PIs supporting network meeting by presenting their own networks and joint presentation of the networks during the BSI meeting 2017 (please refer to Engagement activities for more details).
Collaborator Contribution the MRC/GCRF funded sister "Networks in Vaccine R&D" Hic-Vac, BactiVac, IntVetVacc, Validate and IMPRINT support each other by exchange of knowledge, administrative issues, the network PIs supporting network meeting by presenting their own networks and joint presentation of the networks during the BSI meeting 2017 (please refer to Engagement activities for more details).
Impact Joint meetings and exchange of knowledge on reporting and administrative issues.
Start Year 2017
 
Description Collaboration with the MRC/GCRF funded network BactiVac, University of Birmingham, UK 
Organisation University of Birmingham
Country United Kingdom 
Sector Academic/University 
PI Contribution The MRC/GCRF funded sister "Networks in Vaccine R&D" Hic-Vac, BactiVac, IntVetVacc, Validate and IMPRINT support each other by exchange of knowledge, administrative issues, the network PIs supporting network meeting by presenting their own networks and joint presentation of the networks during the BSI meeting 2017 (please refer to Engagement activities for more details).
Collaborator Contribution The MRC/GCRF funded sister "Networks in Vaccine R&D" Hic-Vac, BactiVac, IntVetVacc, Validate and IMPRINT support each other by exchange of knowledge, administrative issues, the network PIs supporting network meeting by presenting their own networks and joint presentation of the networks during the BSI meeting 2017 (please refer to Engagement activities for more details).
Impact Joint meeting attendance. Exchange of knowledge on reporting to funders and administrative matters.
Start Year 2017
 
Description Collaboration with the MRC/GCRF funded network Validate , University of Oxford, UK 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution The MRC/GCRF funded sister "Networks in Vaccine R&D" Hic-Vac, BactiVac, IntVetVacc, Validate and IMPRINT support each other by exchange of knowledge, administrative issues, the network PIs supporting network meeting by presenting their own networks and joint presentation of the networks during the BSI meeting 2017 (please refer to Engagement activities for more details).
Collaborator Contribution The MRC/GCRF funded sister "Networks in Vaccine R&D" Hic-Vac, BactiVac, IntVetVacc, Validate and IMPRINT support each other by exchange of knowledge, administrative issues, the network PIs supporting network meeting by presenting their own networks and joint presentation of the networks during the BSI meeting 2017 (please refer to Engagement activities for more details).
Impact Joint meeting attendance, exchange of knowledge on reporting to funders and administrative matters.
Start Year 2017
 
Description Imperial College London, UK; Dr Holder 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Dr Holder is member of our network Steering Committee
Collaborator Contribution Dr. Beth Holder is a Lecturer in Maternal and Fetal Health in the Institute of Reproductive Biology (IRDB) and our IMPRINT challenge 1 "Mechanism of production and transfer of maternal antibody via the placenta and breast milk" co-lead. She supports the network with her expertise.
Impact IMPRINT joint events (e.g. London Midwifery Festival, please refer to the section Engagement Activities) and publications. MatImms App for pregnant women (please refer to Engagement Activities).
Start Year 2017
 
Description Johns Hopkins Bloomberg School of Public Health, USA; Dr Bar-Zeev 
Organisation Johns Hopkins University
Department Johns Hopkins Bloomberg School of Public Health
Country United States 
Sector Academic/University 
PI Contribution Narr Bar-Zeev is one of our IMPRINT Steering Committee members
Collaborator Contribution Dr Naor Bar-Zeev is a pediatric infectious diseases physician and statistical epidemiologist. His research interest is in understanding how to maximise the benefit of existing and future vaccines in low-resourced high mortality settings, how best to protect vulnerable groups like newborns and pregnant women and how to optimise methods to evaluate vaccine impact and effectiveness. He is part of our IMPRINT Steering Committee and challenge 6 "Development of comparable methodologies for assessing efficacy in clinical trials" co-lead.
Impact Joint IMPRINT events.
Start Year 2017
 
Description Levy Lab 
Organisation Boston Children's Hospital
Department Levy Laboratory
Country United States 
Sector Hospitals 
PI Contribution set up of systems vaccinology research for studies of EPI vaccines
Collaborator Contribution bioinformatics support
Impact several publications and a grant submission to the nIH
Start Year 2014
 
Description London School of Hygiene and Tropical Medicine and the Vaccine Confidence Project, UK, Prof. Larson 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Heidi Larson is a member of our IMPRINT Steering Committee.
Collaborator Contribution Prof. Heidi J. Larson is an anthropologist and Director of The Vaccine Confidence Project™ (VCP); Professor of Anthropology, Risk and Decision Science, Dept. Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine; Clinical Professor, Institute of Health Metrics & Evaluation, University of Washington; and Chatham House Centre on Global Health Security Fellow. She is a member of our IMPRINT Steering Committee and one of our challenge 4 "Vaccine acceptancy and preparedness for maternal immunisation, including in emergencies" co-leads. IMPRINT is featured as a partner on the vaccine confidence.org website (please refer to Engagement activities for more details).
Impact Joint IMPRINT events.
Start Year 2017
 
Description National Health Services, UK; Dr Mehring-Le Doare 
Organisation National Health Service
PI Contribution Dr Kirsty Mehring-le Doare is one of our IMPRINT Steering Committee members.
Collaborator Contribution Dr Mehring is consultant in Paediatric Infectious Diseases and Immunology, CSAC Training Advisor (PIID). She also functions as one of our IMPRINT Steering Committee members and co-lead of our challenge "Mechanism of production and transfer of maternal antibody via the placenta and breast milk".
Impact Joint IMPRINT events and publications.
Start Year 2017
 
Description PATH 
Organisation PATH
Country Global 
Sector Private 
PI Contribution Path vaccine roadmap work
Collaborator Contribution scientific advice
Impact funding
Start Year 2016
 
Description UCAD 
Organisation University Cheikh Anta Diop de Dakar
Country Senegal 
Sector Academic/University 
PI Contribution Professor Mboup and Professor Gaye are partners in our West African Global Health Research initiative and a number of members of their respective departments are now involved in our research
Collaborator Contribution exchange of ideas and potential for join grant applications
Impact scientific workshops
Start Year 2016
 
Description University of Liverpool, Prof. French 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution Neil French is member of our IMPRINT Steering Committee
Collaborator Contribution Neil French is Professor of Infectious Diseases and Global Health and Hon Consultant Infectious Diseases Royal Liverpool & Broadgreen University Hospitals Trust. He is a member of our IMPRINT Steering Committee and challenge 6 "Development of comparable methodologies for assessing efficacy in clinical trials" co-lead.
Impact Joint IMPRINT events and publications.
Start Year 2017
 
Description University of Oxford, UK; Dr Drakesmith 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Alexander Drakesmith is member of our IMPRINT Steering Committee
Collaborator Contribution Dr Drakesmith´s lab is at the Weatherall Institute of Molecular of Medicine where he studies the role of iron in infectious diseases and the immune response. He is member of our IMPRINT Steering Committee and challenge 3 "Impact of globally important co-factors on maternal and neonatal immunity" co-lead.
Impact Joint IMPRINT events.
Start Year 2017
 
Description University of the Witwatersrand, South Africa; Dr Clare Cutland 
Organisation University of the Witwatersrand
Department Respiratory And Meningeal Pathogens Unit
Country South Africa 
Sector Academic/University 
PI Contribution Clare Cutland is one of our network Executive Committee members.
Collaborator Contribution Dr. Clare Cutland is the Deputy Director at the Respiratory and Meningeal Pathogens Research Unit (RMPRU) based at Chris Hani Baragwanath Academic Hospital (CHBAH), Soweto, South Africa. She has been a sub-investigator/ senior doctor on numerous phase I, II and III paediatric vaccine trials and principal investigator on a phase II paediatric measles vaccine trial and a phase III quadrivalent influenza vaccine trial in children. She is part of our IMPRINT Steering committee group and co-lead of our challenge "Vaccine Safety and Monitorgin in LMIC".
Impact Joint events related to IMPRINT. Publications are currently in preparation.
Start Year 2017
 
Description Blog feature MatIMMS project, Patient Experience Research Center Imperial College London 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The MatImms project consists of a multi-disciplinary research team of midwives, doctors and scientists that investigates vaccination in pregnancy. The project is led by Prof. Beate Kampmann. MatImms encourages vaccination in pregnancy to protect newborn babies from preventable infections. In the laboratory, MatImms studies the impact of vaccines on immunity in mothers and babies. In order to connect with pregnant women, the MatImms Smartphone App has been developed to improve vaccine information available, enabling pregnant women and their support networks to make informed choices. Our challenge 1 co-lead Beth Holder co-developed the App and its contents. IMPRINT is mentioned on the blog news.
Year(s) Of Engagement Activity 2019
URL http://wwwf.imperial.ac.uk/blog/perc/2019/02/11/case-study-15-matimms-involve-women-in-research-addr...
 
Description British Society for Immunology (BSI) Meeting, UK 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Our IMPRINT network manager, Dr Claudia Schacht, together with our sister Network Managers from the VALIDATE Network (Vaccine development for complex intracellular neglected pathogens), IntVetVac (the International Veterinary Vaccinology Network), HIC-Vac (The Human Challenge Model Network) and BactiVac (the Bacterial Vaccines Network) joined forces during the British Society for Immunology (BSI) meeting in Brighton to introduce the networks, attracts new members and talk about the start or our first rounds of funding calls.
Year(s) Of Engagement Activity 2017
URL https://www.immunology.org/events/bsi-congress
 
Description Community sensitisation events 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Participants in your research and patient groups
Results and Impact The community sensitisation events are regularly conducted to inform past, present and future participants in our research on the results of previous studies and upcoming new research studies and clinical trials. They serve as a link to the community decision makers and are well supported by community members and MRC researchers.

Increased participation in clincial trials and ongoign research
Year(s) Of Engagement Activity 2010,2011,2012,2013,2014
 
Description European Society for Pediatric Infectious Diseases (ESPID) meeting cum IMPRINT Research Session, Sweden 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact At the European Society for Pediatric Infectious Diseases meeting in Malmö, Sweden, our network Co-PI Dr Chrissie Jones organized a research session for IMPRINT members and people interested in our network. We aimed to meet with IMPRINT network members attending the conference as well as attracting new members. In addition, Dr Chrissie Jones was also available at the "Meet the Professor" Session and present "a randomized controlled trial comparing two pertussis-containing vaccines in pregnancy and vaccine responses in UK mothers and their infants (Immunizing Mums Against Pertussis, IMAP2).
Year(s) Of Engagement Activity 2018
 
Description IMPRINT Full Network Meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact We held our first full network meeting in Sept 2018 in Kingston upon Thames with a total of 87 participants. At that time, the network was running for 14 months and had a total of 200 members. Travel funds for young scientists, postdocs as well as grant holders were provided. 30% of the participants came from LMIC, 70% from HIC and from a total of 22 different countries. During the meeting, we not only had scientific talks by our pump priming and fellowship holders on their IMPRINT sponsored projects, but also from our GCRF sister network PIs and stakeholders from policy (Ghana Standards Authority and WHO), as well as the Group Strep B support group.. We also had an industry panel discussion with representatives from Pfizer, GSK and Sanofi Pasteur. We offered workshops on the topic of Patient and Public Involvement and grant writing as media training. A speed dating session for networking fostered the interaction between the participants.
Additionally, we supported the career of our IMPRINT sponsored fellows by recording video interviews about their research and career which we will display at the IMPRINT website and provide to the fellows.
We also recorded videos and interviews with our network members on our passion for research, our network of members, our innovational approach and impact. All videos can be seen on our website.
Year(s) Of Engagement Activity 2018
URL http://www.imprint-network.co.uk
 
Description IMPRINT kickoff at INMIS 2017, Brussels 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact IMPRINT official kickoff meeting during 4th International Neonatal & Maternal Immunization Symposium in Brussels in Sept 2017. The network was introduced by the network PIs, Prof. Beate Kampmann, Dr Chrissie Jones, the network manager Dr Claudia Schacht. Presentations were also given by members of the IMPRINT Steering Committee (Heidi Larson, Clare Cutland, Sonali Kochhar). The meeting attracted the first round of membership applicants to our network.
A Steering committee kickoff meeting was held with 8 out of 13 members.
A stakeholder meeting with participants from the Bill and Melinda Gates Foundation, PATH, GSK, Minervax, NIAID, Pfizer and UNICEF was held.
Year(s) Of Engagement Activity 2017
URL http://www.inmis.org/index.php?p=previousInmis
 
Description INMIS media interveiw 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact as part of the International Symposium for neonatal and maternal immunisations hick I organised in The Gambia I gave a television interview to the national media which was broadcasted on the same day
Year(s) Of Engagement Activity 2015
 
Description Impact Science Report 2018 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact IMPRINT was featured in the latest Impact Science Report. Our network PIs Beate Kampmann and Chrissie Jones talked about the "value of vaccination in pregnancy". They discussed our innovative and game-changing network activities as well as the network´s long-term global impact. Our IMPRINT fellow Alansana Darboe is also featured and shares how the IMPRINT fellowship will foster his research career. The article aimed at increasing our visibility and attract new members.
Year(s) Of Engagement Activity 2018
URL http://impact.pub/December2018-2digitaledition/
 
Description Introduction of IMPRINT at the Department of Public Health, Erasmus MC, University Medical Center, Rotterdam 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Sonali Kochhar, one of our network steering committee members presented on maternal immunization to the Department of Public Health, Erasmus MC, University Medical Center, Rotterdam, The Netherlands on 5th Sept 2018 - it was attended by Public Health, Infectious Disease,  Vaccine and clinical research experts at Erasmus MC, University Medical Center, Rotterdam. There was a lot of interest in the IMPRINT network as the attendees hadn´t heard of it. The aim was to increase our network and attract new members.
Year(s) Of Engagement Activity 2018
 
Description London Maternity and Midwifery Festival 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact IMPRINT was promoted at the first London Maternity & Midwifery Festival that took place on February 13th 2018 with over 1600 participants. This national professional festival, with leadership speakers and exhibitions, is to be held annually to highlight developments in maternity and midwifery across the South East of the United Kingdom.

Our IMPRINT network member Beth Holder and a team from London School of Hygiene and Tropical Medicine attended the event to promote MatImms, a free Smartphone App designed by leading experts of paediatric infectious diseases at London School of Hygiene and Tropical Medicine that aims to improve vaccine information available to pregnant women, enabling them to make informed choices and encourages vaccination in pregnancy to protect newborn babies from preventable infections. MatImms collaborate with pregnant women alongside academic, clinical and policy partners such as Public Health England and antenatal services, in the UK and globally through the Centre for International Child Health.
Matimms is led by Professor Beate Kampmann.
We aimed to attract midwifes to our network and spark interest of the general public.
Year(s) Of Engagement Activity 2018
URL http://www.maternityandmidwifery.co.uk/events/london-2018/
 
Description Midwifery conference 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Open Day and midwifery conference at earls Court London, large exhibition of activities, promotion of our App for maternal immunisation
Year(s) Of Engagement Activity 2018
 
Description Partner: IMPRINT and the Vaccine Confidence Project 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Prof Heidi Larson, one of our network challenge leads also holds the position of the director of the Vaccine Confidence Project, based at the London School of Hygiene and Tropical Medicine. The purpose of the project is to monitor public confidence in immunisation programmes by building an information surveillance system for early detection of public concerns around vaccines. IMPRINT is featured as the Vaccine Confidence Partner on their website. We plan to open a call in the near future about patient and public engagement in vaccination, and the Vaccine Confidence project display gives us more visibility.
Year(s) Of Engagement Activity 2018,2019
URL http://www.vaccineconfidence.org
 
Description Project website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact With our website, we aim to build a sustainable network of stakeholders from basic science, immunology, vaccinology, social sciences, industry, public health and national and international policy makers, to tackle the challenges in the best use of vaccines in pregnancy and in newborns, and in the long term to improve maternal and newborn health.
The website helps us to foster capacity for research and innovation within the UK and in developing countries and set up new collaborations.
Year(s) Of Engagement Activity 2017,2018,2019
URL http://www.imprint-network.co.uk
 
Description RE:Action 2017, Magazin of the University of Southampton 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Chrissie Jones and IMPRINT were featured in the The RE:Action Magazine of the University of Southampton, Re:action is the University of Southampton's bi-annual Research and Enterprise newsletter offering insight into public policy related research conducted at the University as well as public engagement and business activities. the article aimed to increase our visibility and attract potential new members to the network.
Year(s) Of Engagement Activity 2017
URL https://e.issuu.com/anonymous-embed.html?u=university_of_southampton&d=web_version_reaction_magazine...
 
Description Stakeholders meeting on Maternal Interventions Vigilance: Safety Monitoring and Surveillance in Vaccine and other Research Settings, WHO Geneva 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Sonali Kochhar introduced IMPRINT during the stakeholder meeting on Maternal Interventions Vigilance at the WHO in Geneva.
Year(s) Of Engagement Activity 2017
URL http://apps.who.int/medicinedocs/documents/s23416en/s23416en.pdf
 
Description Twitter Account 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Our Twitter account engages mainly scientists and the general public. We tweet about the topic of vaccination in general, retweet worldwide funding opportunities and engage with other GRCF funded networks on the topic of immunization. We also tweet about our own funding options. We attracted over 200 followers since Sept 2017.
Year(s) Of Engagement Activity 2017,2018,2019
URL https://twitter.com/imprint_network
 
Description Workshop cum Expert Review Meeting on Maternal Immunization, New Delhi 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Beate Kampmann, our network PI, Beth Holder, our challenge 1 co-lead and Sonali Kochhar, our challenge 5 co-lead, introduced IMPRINT at the "Workshop cum Expert Review Meeting on Maternal Immunization" September 10th in New Delhi, organized by the PRERNA Platform, KEM Hospital Research Centre Pune, with support from WHO-TDR Fellowship in Clinical Research and Development and the Bill and Melinda Gates Foundation. The meeting was attended by global and Indian public health, infectious disease, vaccine and clinical experts.

The objectives of the meeting were to:

- foster discussion among national and global leaders in maternal immunization to identify and prioritise research areas in maternal immunization in India
- initiate research proposals
- development in maternal immunization in collaboration with national and international partners
Year(s) Of Engagement Activity 2018
URL http://www.prernaindia.in/images/mi.pdf