THE IMPACT OF EARLY ADVERSITY ON TRAJECTORIES OF BRAIN MATURATION AND MENTAL HEALTH IN YOUNG ADOLESCENTS

Lead Research Organisation: King's College London
Department Name: Psychosis Studies

Abstract

WHAT IS THE PROPOSED STUDY ABOUT?
Psychiatric disorders, like depression, schizophrenia, bipolar disorder, and anxiety affect millions of people around the world. They disturb thinking, mood, and behaviour, and can interfere with daily life with devastating effects. They usually strike at a young age and it is very important to understand how early in the life of an individual we are still able to intervene and modify the risk of developing these disorders. For example, the risk is higher in those who have experienced trauma and adversity, and in those living in deprived social conditions. However, we do not know if the brain develops differently in those adolescents with adversity, and whether this explains why they are more likely to experience certain types of mental health problems. Furthermore, we do not know whether factors such as growing up in a very supportive family environment, or having higher general intelligence, may protect some adolescents from the effects of early adversity, preventing the brain from developing differently and from experiencing psychiatric symptoms later on.

WHAT IS ALREADY KNOWN ABOUT THIS AREA?
We know that individuals who have suffered traumatic experiences, and those with mental health problems, show alterations in the structure of the brain. For example, regions involved in memory (frontal lobe, hippocampus) are smaller in volumes. However, we do not know when these alterations start, or whether they stay the same throughout adolescence. Also, we do not know whether they particularly occur in those adolescents that have an activation of the body's response to stress. In fact, the activation of the stress system triggers a response in the "immune system", the system dedicated to fight infections in our body. This is a situation also seen in patients with depression and schizophrenia, whose bodies behave as if they were fighting an infective agent, even though they do not have an ongoing infection.

Therefore, it is possible that social adversity and this immune response interact with an underlying vulnerability in the brain, causing the brain to develop differently across adolescence, and making the person more likely to experience certain mental health problems, such as depression or psychosis. Unfortunately, the development of the brain throughout the full adolescence, and its relationship with the environment, and the immune system, in adolescents from the general community has never been studied. This is what we are planning to do in this study.

WHAT WILL THE STUDY INVOLVE?
We propose to evaluate and follow up 440 school adolescents (age 11-14 years), with and without an experience of adversity, who are already participating in other studies on risk factors for poor mental health. These studies are being conducted in the UK and in six other European countries. We will evaluate these adolescents three times, over a few years. Each time, we will assess brain structure and immune response. We will use an approach called "magnetic resonance", which allows us to look at the brain structure without using radiations, and to look at how brain changes over time. We will measure immune response in a blood sample. This study has the big advantage that more than half of these adolescents have already been evaluated with these measures in the two studies, and we will simply access the existing assessments.

HOW WILL THE STUDY HELP PEOPLE WITH MENTAL HEALTH PROBLEMS?
We are confident that this study can help us understand what are the times when adolescents are most vulnerable to mental health problems, when interventions (talking therapy or medications) can reduce risk of adverse mental health outcomes.

Technical Summary

RESEARCH OBJECTIVES: Mental disorders usually develop in young individuals, and the risk is increased by exposure to early adversity, such as childhood maltreatment, adverse life events, and area-level disadvantage. We will establish: 1) How and when individual and area-level early adversity affects brain development (i.e., longitudinal growth trajectory of brain areas involved in psychiatric disorders, built on three longitudinal brain MRI scans); 2) Whether these alterations in growth trajectory are associated with the onset of specific psychopathology domains; and 3) If these alterations in growth trajectory are explained by persistent alterations in the levels of inflammatory markers.

EXPERIMENTAL DESIGN: We will study n=440 children and young adolescents (age 11-14) from two funded school-based longitudinal cohorts. We will enrich the existing data by collecting additional neuroimaging and immune markers measures in n=220 subjects from each cohort, selected for presence (n=110) or absence (n=110) of early adversity:
- In REACH (UK; original sample n=4010), with three MRI assessments over three years, and serum samples for immune biomarkers;
- In IMAGEN (Six EU countries; original sample n=2000) (three MRI assessments already available), with measures of immune markers in already collected serum samples;

We will model the relationship between early adversity, brain growth, psychopathology domains, and immune markers, using multivariable statistical models.

APPLICATION OF RESULTS: Characterising the biological changes associated with risk of mental health problems can ultimately provide evidence for targeting interventions to the most vulnerable individuals.

Planned Impact

The lack of knowledge on the neurobiological link between early individual and environmental adversity and poor mental health has hindered the development of targeted, cost-effective prophylactic and therapeutic interventions for those most at risk. Therefore, the impact of this study will go far beyond that of academic research (see Academic beneficiaries for details on this aspect), starting to pave the way for novel interventions and personalised medicine where treatment decisions can be made based on the individual's characteristics.

IMPACT ON NATIONAL HEALTH:
- We will benefit young people with a history of early adversity and poor mental health, offering a model that may help identify the most vulnerable individuals, at a crucial developmental point. We will offer them a rationale for stress management and innovative pathways for potential future drug discovery (such as anti-inflammatory agents). We will benefit patients' families and loved ones will benefit from improvement in the conceptualisation of how adversity drives poor mental health and how resilience can be strengthened, with available intervention strategies. The timescale for this is medium to long-term: if brain and immune markers can reliably help identifying times of maximum vulnerability for the onset of psychopathology, anti-inflammatory agents could be trialled in this population as they are currently trialled in clinically manifest depression and psychosis; furthermore, stress-coping strategies could be delivered in a cost-effective way in the context of limited health care resources.
- The lay public will also benefit from our work: a non-stigmatising approach based on a sound biological basis to understand vulnerability to poor mental health, and an explanatory model that emphasises not only risk factors but also resilience and possible future therapeutic interventions. The time-scale for this is therefore immediate, as we intend to vigorously disseminate our findings to the general public.
- Stakeholders in health care, such as charities and non-governmental organisations, will benefit from the model we propose. Understanding how neurobiological changes at specific time points in adolescence allow early adversity to drive poor mental health can inform how interventions could be used in a more selective and personalized way, potentially improving mental health outcomes and avoiding unnecessary exposure to drugs or long-term psychological interventions. The time-scale for this is also immediate, and we have an effective communication strategy to reach stakeholders and third-sector organisations.
- Research & Development leaders, from service developers, pharmaceuticals and biotech companies, will benefit from the evidence offered by our study: it will guide them in prioritizing resources, in the difficult times ahead, identifying potential new mechanisms for novel agents relevant to brain plasticity, neurodevelopment and peripheral biomarkers, as well as biomarkers for personalised medicine and stratification. With effective communication, the time-scale for this is medium/long-term.

IMPACT ON NATIONAL WEALTH:
- Mental health problems in adolescence often persist into adulthood and consequently have long term impacts on individuals and their families and friends, with knock on effects on productivity, use of health care services, and demand for welfare assistance. That is, there are large associated direct costs to individuals, families, and health and other services, and indirect costs for the loss of productivity. Any study that can help elucidate the processes underpinning the development of mental health problems and inform strategies for prevention and intervention, will be beneficial to society at large. This is particularly important at a time when healthcare and social resources are increasingly stretched.

Publications

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Grande AJ (2022) Mental health interventions for suicide prevention among indigenous adolescents: a systematic review. in Sao Paulo medical journal = Revista paulista de medicina

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Hazelgrove K (2021) The role of the immune system in postpartum psychosis. in Brain, behavior, & immunity - health

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Jelen LA (2022) The opioid system in depression. in Neuroscience and biobehavioral reviews

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Lawrence A (2022) Neurocognitive Measures of Self-blame and Risk Prediction Models of Recurrence in Major Depressive Disorder in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

 
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Description Collaboration with GUSTO cohort 
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Description Collaboration with GUSTO cohort 
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PI Contribution Please note that the Department with which we collaborate is not the Genome Institute but the Translational Research Group. The system did not allow me to modify what it entered automatically. The collaboration also involves National University of Singapore (Department of Psychological Medicine). We are collaborating on the analysis of data that have been acquired in a similar way across the two studies. We have one PhD student that is using the two cohorts in her project. In addition, the PI (Dazzan) has spent time at AStar in Singapore discussing and conducting analysis of data from the two cohorts. We are planning some publications together, with one already undergoing second revision in Biological Psychiatry. Several presentations have been given to International conferences.
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PI Contribution We have contributed to establish a network of longitudinal studies in first episode psychosis. We have given intellectual contribution to the use of the partner innovative imaging analysis approaches to test hypotheses relevant to psychosis.
Collaborator Contribution Our partners have provided innovative pipelines and analytical approaches to the use of neuroimaging data in the study of psychosis outcomes.
Impact We have published three high impact papers together and have another one in submission.
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PI Contribution We have contributed to establish a network of longitudinal studies in first episode psychosis. We have given intellectual contribution to the use of the partner innovative imaging analysis approaches to test hypotheses relevant to psychosis.
Collaborator Contribution Our partners have provided innovative pipelines and analytical approaches to the use of neuroimaging data in the study of psychosis outcomes.
Impact We have published three high impact papers together and have another one in submission.
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Description City Heights Academy - Careers in STEM talk 
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Results and Impact Delivered 4 x workshops to Y9 students about Careers in STEM which generated excellent discussion about the realities of working in research.
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Description Harris City Academy Crystal Palace Mental Health Assembly 
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Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact 4 presentations/sessions pre-recorded and delivered during assemblies at Harris City Academy focusing on Mental health awareness, Recognising anxiety and depression, Managing anxiety and depression, and Mindfulness.
Year(s) Of Engagement Activity 2020
 
Description Harris City Academy Crystal Palace Mood Regulation Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact A one-hour workshop with students at Harris City Academy from a mix of year groups. The workshop focussed on mood regulation skills with interactive activities and discussion within the group.
Year(s) Of Engagement Activity 2020
 
Description Harris Girls Academy Careers event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact A careers event where a number of members of the public submitted videos speaking about their careers.
Year(s) Of Engagement Activity 2020
 
Description How do you keep sane as a creative? An interview with our new columnist, novelist Natali J Simmonds - blog 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog written on Inspire the Mind by CELEBRATE project Investigator
Year(s) Of Engagement Activity 2023
URL https://www.inspirethemind.org/post/how-do-you-keep-sane-as-a-creative-an-interview-with-our-new-col...
 
Description In for 2024: Tackling stress by embracing the power of routine - blog 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog written on Inspire the Mind by CELEBRATE project team member.
Year(s) Of Engagement Activity 2024
URL https://www.inspirethemind.org/post/in-for-2024-tackling-stress-by-embracing-the-power-of-routine
 
Description Inflammation might be one of the keys to unlock depression - blog 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog written on Inspire the Mind by CELEBRATE project team member.
Year(s) Of Engagement Activity 2023
URL https://www.inspirethemind.org/post/inflammation-might-be-one-of-the-keys-to-unlock-depression
 
Description Is it on Brand? Sexual Harassment Within, and Beyond, the Comedy World. - blog 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog written on Inspire the Mind by CELEBRATE project member
Year(s) Of Engagement Activity 2023
URL https://www.inspirethemind.org/post/is-it-on-brand-sexual-harassment-within-and-beyond-the-comedy-wo...
 
Description It's More Than Just a Sport: A Self-Discovery Journey - blog 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog written on Inspire the Mind by CELEBRATE project team member.
Year(s) Of Engagement Activity 2023
URL https://www.inspirethemind.org/post/it-s-more-than-just-a-sport-a-self-discovery-journey
 
Description Karl Lagerfeld: A Line of Beauty and a History of Hate Speech - blog 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog written on Inspire the Mind by CELEBRATE project team member
Year(s) Of Engagement Activity 2023
URL https://www.inspirethemind.org/post/karl-lagerfeld-a-line-of-beauty-and-a-history-of-hate-speech
 
Description Key note speech 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Key note speech at the event "Women on the Move through Relationships", organised by University of Bologna
Year(s) Of Engagement Activity 2022
 
Description Language We Should and Shouldn't Use When Talking About Mental Health - blog 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog written on Inspire the Mind but CELEBRATE project team member.
Year(s) Of Engagement Activity 2023
URL https://www.inspirethemind.org/post/language-we-should-and-shouldn-t-use-when-talking-about-mental-h...
 
Description Managing Anxiety Workshops - Canary Wharf Crossharbour School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact We were invited to the school to lead a series of workshops to small groups of students in Key Stage 3; 4 workshops for 3 groups. Participants in the workshops learnt about anxiety and had good discussions about what anxiety feels like, how to manage anxiety.
Participants in the workshops made
Year(s) Of Engagement Activity 2021
 
Description Managing Stress Workshops - Harris City Academy Crystal Palace 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Presentations to students in Y7, 8, 9, 10, 11 at City Academy regarding mental health awareness, managing anxiety and stress management.
Year(s) Of Engagement Activity 2022
 
Description Managing stress 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact I was interviewed by a member of News.UK on stress, consequences of stress, and top tips to cope with stress and burnout, and my research on the topic.
Year(s) Of Engagement Activity 2024
 
Description Mental Health Assembly @ Harris Academy Peckham 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact 30 minute long assembly to whole year group at Harris Academy Peckham about mental health and the eBRAIN study
Year(s) Of Engagement Activity 2022
 
Description Mental Health Assembly @ Harris Boys East Dulwich 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact 45 minute assembly at Harris Academy Boys to years 7, 8 and 9 about mental health and the eBRAIN study at KCL
Year(s) Of Engagement Activity 2022
 
Description Mental Health Awareness Assembly 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact We gave a virtual presentation (over Teams) to students in Year 7 regarding Mental health awareness and stigma which resulted in discussion with students.
Year(s) Of Engagement Activity 2021
 
Description Mental Health School Workshops 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Spoke to students at a local school about mental health, stress and anxiety and about the eBRAIN study at KCL
Year(s) Of Engagement Activity 2022
 
Description Mental Health, Young People and the Arts 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Third sector organisations
Results and Impact An event discussing the potential role of arts to help mental health problems
Year(s) Of Engagement Activity 2022
 
Description Presentation to Harvard Grand Rounds 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact I was invited to give a presentation to the Beth Israel Deaconess Medical Center Harvard Psychiatry Grand Round. This increased awareness of the challenges of personalised medicine in psychiatry
Year(s) Of Engagement Activity 2024
 
Description Presentation to National University of Singapore 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact I gave a presentation on my research and increased awareness on new approaches in neuroimaging applied to psychiatric disorders.
Year(s) Of Engagement Activity 2023
 
Description Professor Matthew Hotopf on 'Where is psychiatry going?' - blog 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog written on Inspire the Mind by CELEBRATE project Investigator
Year(s) Of Engagement Activity 2023
URL https://www.inspirethemind.org/post/professor-matthew-hotopf-on-where-is-psychiatry-going
 
Description Reach Festival of Young People 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Attended the Young Person Festival in Brixton hosted by the REACH study and Big Kid Foundation. Researchers for eBRAIN spoke at the event, hosted a stall and networked with other 3rd sector orgs and young people people who attended the event. Had many conversations about the eBRAIN study and mental health research in general which generated good discussion.
Year(s) Of Engagement Activity 2021
 
Description School visit (Harris City Academy Crystal Palace) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact About 20-25 teachers attended the Workshop that focused on wellbeing at work, the impact of stress on mental health and stress management. This raised interest in the teachers on the effects of stress on biological mechanisms of response to stress and the consequences on mental health as well as on the developing brain. The audience gave excellent feedback and asked for more of these engagement activities to be carried out in their school.
Year(s) Of Engagement Activity 2020
 
Description School visit (Harris City Academy Crystal Palace), Parents Evening 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact We attended a Parents Evening where we had a stand on this MRC funded study and spoke to a large number of parents and pupils about the study as well as about resilience, mental health, brain development and stress coping. We had really positive engagement and this was also an opportunity to see again some of the pupils and parents who had already taken part in the study.
Year(s) Of Engagement Activity 2020
 
Description School visit (Oasis Academy Arena) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact This was a Personal Social Health Education 1-hour talk delivered to about 120 pupils from Year 7 about mental health awareness and destigmatising mental health problems. There was a good Q&A session afterwords, including questions about how to support pupils or friends with mental health problems.
Year(s) Of Engagement Activity 2020
 
Description St Mary's School Croydon - Careers in STEM sessions 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Workshops given to small groups of Y9 students regarding careers in STEM.
Year(s) Of Engagement Activity 2021
 
Description St Mary's School Croydon - Mental Health Workshops 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Workshops on managing anxiety and stress to Y9 students in small groups.
Year(s) Of Engagement Activity 2021
 
Description St Thomas More School - maintaining boundaries workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact We provided an hour long workshop to classes in KS3 at St Thomas More School in Eltham by request of the wellbeing lead at the school. The workshops lead to good discussion between the students and resulted in us being invited back for further sessions.
Year(s) Of Engagement Activity 2021
 
Description Supporting blog writing from one of my research team members 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Series of blogs in the IoPPN on a section on Postgraduate Studies, covering academic life and mental wellbeing.
Year(s) Of Engagement Activity 2020,2021
URL https://blogs.kcl.ac.uk/ioppn-students/author/k1803052/
 
Description Supporting blog writing on mental health topics related to our work 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact I encourage blog writing from my researchers. This has been a blog on how to destigmatise and find support when having suicidal ideation, a very important topic for both our adolescent population and youths with mental health problems..
Year(s) Of Engagement Activity 2021
URL https://www.inspirethemind.org/blog/finding-tranquillity-in-the-raging-sea-of-suicide
 
Description The Burden of Catcalling and Street Harassment - blog 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog written on Inspire the Mind by CELEBRATE project team member.
Year(s) Of Engagement Activity 2023
URL https://www.inspirethemind.org/post/the-burden-of-catcalling-and-street-harassment
 
Description The Met Police to Stop Attending Mental Health Callouts: The Inspire The Mind View (Part 1) - blog 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog written on Inspire the Mind by CELEBRATE project team member.
Year(s) Of Engagement Activity 2023
URL https://www.inspirethemind.org/post/the-met-police-to-stop-attending-mental-health-callouts-the-insp...
 
Description The Met to Stop Attending Mental Health Callouts in London: The Inspire The Mind View (Part 2) - blog 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog written on Inspire the Mind by CELEBRATE project team member
Year(s) Of Engagement Activity 2023
URL https://www.inspirethemind.org/post/the-met-to-stop-attending-mental-health-callouts-in-london-the-i...
 
Description The Trials and Tribulations of Moral Perfectionism - Blog 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog written for Inspire the Mind by CELEBRATE project team member.
Year(s) Of Engagement Activity 2023
URL https://www.inspirethemind.org/post/the-trials-and-tribulations-of-moral-perfectionism
 
Description The eBRAIN Study: My Thoughts and Experiences - blog 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog written on Inspire the Mind by former participant of the eBRAIN study about their why they wanted to take part in the study and their experience of taking part.
Year(s) Of Engagement Activity 2023
URL https://www.inspirethemind.org/post/the-ebrain-study-my-thoughts-and-experiences
 
Description The life of a Third Culture Kid - blog 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog written on Inspire the Mind by CELEBRATE project team member
Year(s) Of Engagement Activity 2024
URL https://www.inspirethemind.org/post/the-life-of-a-third-culture-kid
 
Description The status of psychiatric research - blog 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog written on Inspire the Mind by CELEBRATE project Team Member
Year(s) Of Engagement Activity 2022
URL https://www.inspirethemind.org/post/the-status-of-psychiatric-research
 
Description Training Day for L2 Biomed students at Brunel University London 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Host a stall at a careers event at Brunel University London which was attended by >100 undergraduate and postgraduate students who were studying Biomedical Sciences and were interested in doing a placement year. I spoke to them about my work experience abroad during my undergraduate studies, my experience working as a research assistant on the eBRAIN study and provided advice and help with career development.
Year(s) Of Engagement Activity 2023
 
Description Twitter account 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact I use Twitter to disseminate information about mental health and diversity and inclusion.
Year(s) Of Engagement Activity 2019,2020,2021
URL https://twitter.com/paola_DZN
 
Description Voices of Tomorrow: A CELEBRATE Project Event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact One of our YEWG members, Kirsten, moderated and co-facilitated a panel discussion. She asked our panel members questions including "How can young people benefit from being involved in mental health research?", or "What is the role of social media in helping or hindering mental health online? What role can influencers play in addressing these issues?". Fera, another YEWG member, spoke about her personal experience surrounding inclusivity in research and represented today's youth. Including our YEWG members on the panel was a great opportunity for the audience to actively engage and hear all about their experiences, as well as their opinions on the CELEBRATE project. Niyah Campbell, our youth involvement co-lead from the University of Birmingham was on our panel, which also included Dr Gillian Brooks who co-moderated as our representative of King's Business School.
Year(s) Of Engagement Activity 2024
URL https://www.kcl.ac.uk/voices-of-tomorrow-a-celebrate-project-event
 
Description Voices of Tomorrow: Celebrating young people in mental health research 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact We held a CELEBRATE project event which included a panel discussion and networking opportunities. ~80 people attended, including some young people, academics, influencers, and members of the general public. The event was an opportunity to promote the project and highlight the importance of including young people in research. New partnership opportunities have arisen from the event.
Year(s) Of Engagement Activity 2024
 
Description Work Experience Students 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Hosted 5 students for 1 week long work experience placements at IoPPN
Year(s) Of Engagement Activity 2023
 
Description Workshop for school children 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact About 50 pupils attended the school visit, oriented towards providing an introduction to science, laboratory work and how the brain works. This stimulated discussion on mental health and how to remain healthy.
Year(s) Of Engagement Activity 2019
 
Description World Refugee Day: Mental Health after Fleeing - blog 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog on Inspire the Mind by CELEBRATE project team member.
Year(s) Of Engagement Activity 2023
URL https://www.inspirethemind.org/post/world-refugee-day-mental-health-after-fleeing
 
Description Year 11 School Visit (Harris City Academy Crystal Palace) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact We delivered a 30 minutes talk on How to Manage Exam Stress to approximately 150 Year 11 pupils, followed by a lively Q&A session.
Year(s) Of Engagement Activity 2020
 
Description Year 12 School visit (Harris City Academy Crystal Palace) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact We delivered two workshops, lasting 2 hours each part of a Career Day, to an audience of school Year 12 pupils, as well as representatives from industry, business, counselling and supporters, as well as general public. The workshop focused on managing your mental health throughout University and while developing your career. This was a very lively session, with many questions and positive feedback.
Year(s) Of Engagement Activity 2020
 
Description Youth Expert Working Group 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact We have set up a Youth Expert Working Group (YEWG) which includes young people interested in research, aged between 11-18. In this group, the YEWG members are active contributors to the research and dissemination of the project. We have monthly meetings, were the YEWG members are updated on the project and asked to provide input and feedback.
Year(s) Of Engagement Activity 2023,2024
 
Description Youth Expert Working Group Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Assisted in forming a youth expert working group of young people from across the country, including a number of young people from London who have participated or been involved with eBRAIN.
The primary function of the working group was to help co produce a new study 'CELEBRATE' which aims to investigate the barriers and facilitators for young people being involved with biological research.
Meetings of this YEWG are ongoing.
Year(s) Of Engagement Activity 2022,2023
 
Description e-BRAIN Spring Newsletter May 2023 - Newsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Study participants or study members
Results and Impact A newsletter that is created by members of the eBRAIN research team and sent out to participants and their families so that they can find out about any outcomes of the research, provide updates related to the study as well as digestible scientific information and small activities like quizzes or crosswords etc.
Year(s) Of Engagement Activity 2023
URL https://www.ebrainstudy.com/blog
 
Description e-BRAIN Winter Newsletter December 2023 - Newsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Study participants or study members
Results and Impact A newsletter that is created by members of the eBRAIN research team and sent out to participants and their families so that they can find out about any outcomes of the research, provide updates related to the study as well as digestible scientific information and small activities like quizzes or crosswords etc.
Year(s) Of Engagement Activity 2023
URL https://www.ebrainstudy.com/blog
 
Description eBRAIN Facebook page 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact eBRAIN Facebook page set up to disseminate information about the study. Highest reach for a single post was over 1000 people.
Year(s) Of Engagement Activity 2020,2021
URL https://www.facebook.com/ebrainstudy
 
Description eBRAIN Spring newsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact First edition of the eBRAIN newsletter published, emailed to study participants, their parents and collaborating schools.
Year(s) Of Engagement Activity 2020
URL https://www.ebrainstudy.com/blog
 
Description eBRAIN twitter 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact eBRAIN Twitter feed set up to disseminate information and news about the study, and generally share information regarding youth mental health and related topics. Tweet impressions have peaked so far at 17.5k in March 2021.
Year(s) Of Engagement Activity 2020,2021
URL https://twitter.com/e_brainstudy?lang=en
 
Description eBRAIN website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact eBRAIN study website contains information about the study and how to participate, an option to get in touch with the study team, and links to additional resources including blogs and information about mental health.
Year(s) Of Engagement Activity 2020,2021
URL https://www.ebrainstudy.com/
 
Description eBRAIN winter newsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Study participants or study members
Results and Impact Winter edition of the eBRAIN study newsletter emailed out to participants, parents, and collaborating schools.
Year(s) Of Engagement Activity 2021
URL https://www.ebrainstudy.com/blog
 
Description https://www.inspirethemind.org/post/like-the-white-rabbit-we-re-late-or-so-says-social-media - blog 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog written on Inspire the Mind by CELEBRATE project member.
Year(s) Of Engagement Activity 2023
URL https://www.inspirethemind.org/post/like-the-white-rabbit-we-re-late-or-so-says-social-media
 
Description https://www.inspirethemind.org/post/stuck-in-the-spiral-of-what-if-understanding-the-basics-of-catastrophising - blog 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog written on Inspire the Mind by CELEBRATE project team member.
Year(s) Of Engagement Activity 2023
URL https://www.inspirethemind.org/post/stuck-in-the-spiral-of-what-if-understanding-the-basics-of-catas...
 
Description • The Johnny Depp Defamation Trial: The Media's Damaging Portrayal of Personality Disorders 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Blog written for Inspire the Mind written by eBRAIN team member
Year(s) Of Engagement Activity 2022