Using genetic variability in whole transcriptome expression in cells and tissues to understand the pathogenesis of Parkinson's and Alzheimer's disease
Lead Research Organisation:
University College London
Department Name: Institute of Neurology
Abstract
Parkinson's and Alzheimer's disease (PD & AD) are common diseases that affect the brain, causing certain cells to die. When these cells are lost people experience, amongst other problems, difficulty remembering recent events in the case of AD and difficulties moving in the case of PD. At the moment these diseases affect over 1 million people in the United Kingdom with a devastating impact on patients and their families. Since both these diseases become more common with age, the number of sufferers is likely to increase as the number of elderly people rises in the UK. Unfortunately, at the moment we know relatively little about why certain people suffer from these diseases and until we do it is hard for researchers and doctors to develop effective treatments.
In the past 3 years scientists have been able to show that some individuals have common changes in their DNA (the instruction manual for all the building blocks needed to make the human body) that put them at higher risk of developing these conditions. Although this has been an amazing step forward, it has not been easy for scientists to understand how these changes in the DNA, termed genetic risk factors, act to help cause disease. Many people believe that one way in which these genetic risk factors might cause disease is by changing how much or the way in which particular genes (the basic building blocks) are expressed in brain cells. In order to check this, researchers need to make measurements about the genetic variation an individual carries and link this information to the genes they express in their cells.
Although this type of investigation is particularly challenging for diseases that affect the brain, it is possible and meeting those challenges is the aim of this project. One of the difficulties is accurately measuring the amount of the gene expressed in the right cells in the brain. The brain is extremely complex and even within a single region there are many different types of cells. We will address this problem by making use of a technique called laser capture microdissection to obtain pure collections of cells from brain regions relevant to PD and AD. In this technique, using very thin slices of the human brain tissue, we shoot out just the cells we are interested in collecting with a high power laser and then extract the RNA (the gene copies) from the pellets we shoot out. Another advance is the advent of new technology for measuring all the genes expressed in a single cell type or tissue sample. This technology is called "RNA-seq" or "whole transcriptome sequencing" and it allows us to measure all kinds of gene product from any gene. It also allows us to measure the relative quantities of alternative versions of the same gene, and to measure these quantities in such a way that the influence of genetic risk factors can be more sensitively detected by directly comparing the relative product quantities in individuals who happen to have both a "good" and a "bad" copy of a given genetic variant.
We believe that we are in an ideal position to complete this project and so add important insights to the understanding of PD and AD. We already have many of the RNA samples needed to perform this study and while some new RNA samples will be created during the project, through our close collaboration with the MRC Sudden Death Brain and Tissue Bank in Edinburgh we have the brain samples needed to do this (all of which have been donated for research). We have also already carried out extensive analysis of DNA from these samples, which means that the new information we generate during this grant can be quickly and cost-effectively added to existing sources of data in order to progress this research. As a final benefit, all the data we will generate on the human brain will be made publically available so that other scientists interested in understanding how the human brain works in health and disease can use this information.
In the past 3 years scientists have been able to show that some individuals have common changes in their DNA (the instruction manual for all the building blocks needed to make the human body) that put them at higher risk of developing these conditions. Although this has been an amazing step forward, it has not been easy for scientists to understand how these changes in the DNA, termed genetic risk factors, act to help cause disease. Many people believe that one way in which these genetic risk factors might cause disease is by changing how much or the way in which particular genes (the basic building blocks) are expressed in brain cells. In order to check this, researchers need to make measurements about the genetic variation an individual carries and link this information to the genes they express in their cells.
Although this type of investigation is particularly challenging for diseases that affect the brain, it is possible and meeting those challenges is the aim of this project. One of the difficulties is accurately measuring the amount of the gene expressed in the right cells in the brain. The brain is extremely complex and even within a single region there are many different types of cells. We will address this problem by making use of a technique called laser capture microdissection to obtain pure collections of cells from brain regions relevant to PD and AD. In this technique, using very thin slices of the human brain tissue, we shoot out just the cells we are interested in collecting with a high power laser and then extract the RNA (the gene copies) from the pellets we shoot out. Another advance is the advent of new technology for measuring all the genes expressed in a single cell type or tissue sample. This technology is called "RNA-seq" or "whole transcriptome sequencing" and it allows us to measure all kinds of gene product from any gene. It also allows us to measure the relative quantities of alternative versions of the same gene, and to measure these quantities in such a way that the influence of genetic risk factors can be more sensitively detected by directly comparing the relative product quantities in individuals who happen to have both a "good" and a "bad" copy of a given genetic variant.
We believe that we are in an ideal position to complete this project and so add important insights to the understanding of PD and AD. We already have many of the RNA samples needed to perform this study and while some new RNA samples will be created during the project, through our close collaboration with the MRC Sudden Death Brain and Tissue Bank in Edinburgh we have the brain samples needed to do this (all of which have been donated for research). We have also already carried out extensive analysis of DNA from these samples, which means that the new information we generate during this grant can be quickly and cost-effectively added to existing sources of data in order to progress this research. As a final benefit, all the data we will generate on the human brain will be made publically available so that other scientists interested in understanding how the human brain works in health and disease can use this information.
Technical Summary
The aim of this study is to determine the effect of genetic risk factors on whole transcriptome expression in brain regions and cell types most vulnerable to Parkinson's and Alzheimer's disease (PD and AD) in order to understand the pathogenic processes underlying these conditions. This project is inspired by the recent discovery of 15 new genetic risk variants for PD and 13 new loci for AD. However, knowing the genomic position of risk variants is not equivalent to knowing how they act in terms of the underlying molecular processes or where they act in terms of the regional or cellular location. We aim to address both these issues. Using control post-mortem human brain tissue originating from 150 individuals, we will use expression quantitative trait locus (eQTL) mapping and allele-specific expression (ASE) analysis to identify loci that both change disease risk and regulate the expression of specific gene transcripts within specific tissues/cells. We will conduct these studies within the tissues and cells most relevant to PD and AD, namely the substantia nigra, hippocampus, temporal cortex, dopaminergic neurons, CA1 neurons, pyramidal neurons and astrocytes. Existing exome sequencing and SNP array data will be combined with whole transcriptome RNA sequencing data generated on the Illumina HiSeq2000 platform for downstream analysis. These two types of information - genetic variation and transcript expression - will be used for eQTL mapping in tissues and ASE analysis in cells. In both cases the eQTLs identified will be annotated for disease-relevance in the first instance. All the data generated by this project will be publicly released as both raw data files for re-analysis and processed information suitable for non-expert users through NCBI's Gene Expression Omnibus repository and Phenotype-Genotype Integrator sites. Thus, we will generate novel disease-relevant findings and provide the neuroscience community with a world-class resource.
Planned Impact
The goal of this work is to develop comprehensive databases which allow the interpretation of the genome wide association studies (GWAS) for the two most common neurodegenerative diseases, Parkinson's and Alzheimer's disease (PD and AD). In this way, we will improve our understanding of the pathogenic processes underlying these diseases and in the long term improve the diagnosis and treatment of patients struggling to cope with these debilitating diseases. Reaching this goal will require many intermediate steps and we describe who we envisage using our research findings and how this data will help them.
Researchers interested in the follow up of GWAS data: This study was designed to improve our understanding of the molecular mode of action and cellular location in which genetic risk variants for PD and AD act. Therefore, the most obvious users of our data are the original AD and PD consortia. However, the results of this study will also be useful for the interpretation of GWAS for other neurological and psychiatric disorders, making it relevant to researchers interested in the results of GWAS in frontotemporal dementia, epilepsy, depression and schizophrenia to name a few. Since we are publicly releasing all findings through the NCBI's searchable database, Phenotype-Genotype Integrator, we envisage other less specialist researchers also accessing and using the data. These individuals include clinicians, epidemiologists and drug companies interested in following up GWAS hits for clinical trial design or biomarker development.
Researchers interested in the creation and use of in vitro model systems: The cell-specific whole transcriptome sequencing data produced in this project will be a baseline for the detailed molecular assessment of stem cell-based disease models. We will work collaboratively with researchers in the University of Edinburgh (Dr. Kunath & Dr. Chandran) and Cambridge University (Dr. Livesey) to identify the strengths and weaknesses of existing cell models and work to improve the accuracy of these systems. Thus, we will contribute to the development of new research tools for use by the neuroscience research community within universities and in the private setting.
Basic neurobiologists: The large gene expression data sets we are producing will provide insights into other aspects of basic neurobiology. For example, it will be of value to those researchers interested in analysing sex differences in transcript expression. Using this data it will be possible to improve our understanding of the basis of well recognised differences in the incidence, presentation and response to treatment of many neurological disorders. This could in turn contribute to the drive towards individualised patient assessment and care.
Bioinformaticians & statistical geneticists: The raw genotyping, exome and RNA sequencing data will be used by statistical genetics and bioinformatics wishing to test and develop new statistical and analytical methods. In particular, the existence of paired exome sequencing and SNP array data will allow researchers to objectively test and improve methods for the imputation of genetic data. Therefore, we will directly contribute to one of the MRC's stated aims, the training of more researchers and clinicians in bioinformatics.
Charities & patient groups: The discovery of genetic risk variants for PD and AD represent one of the most significant steps forward in the understanding of these diseases in the last 10 years. Therefore, they are hugely important to patients and carers who desperately want to see progress in the diagnosis and treatment of their diseases. From our own experience of hosting visits for Parkinson's Disease UK, Alzheimer's Research UK and the Michael J Fox Foundation, we recognise the importance of engaging with patients and communicating the findings generated from our research in order to maintain hope, create novel resources and improve the uptake of clinical trials.
Researchers interested in the follow up of GWAS data: This study was designed to improve our understanding of the molecular mode of action and cellular location in which genetic risk variants for PD and AD act. Therefore, the most obvious users of our data are the original AD and PD consortia. However, the results of this study will also be useful for the interpretation of GWAS for other neurological and psychiatric disorders, making it relevant to researchers interested in the results of GWAS in frontotemporal dementia, epilepsy, depression and schizophrenia to name a few. Since we are publicly releasing all findings through the NCBI's searchable database, Phenotype-Genotype Integrator, we envisage other less specialist researchers also accessing and using the data. These individuals include clinicians, epidemiologists and drug companies interested in following up GWAS hits for clinical trial design or biomarker development.
Researchers interested in the creation and use of in vitro model systems: The cell-specific whole transcriptome sequencing data produced in this project will be a baseline for the detailed molecular assessment of stem cell-based disease models. We will work collaboratively with researchers in the University of Edinburgh (Dr. Kunath & Dr. Chandran) and Cambridge University (Dr. Livesey) to identify the strengths and weaknesses of existing cell models and work to improve the accuracy of these systems. Thus, we will contribute to the development of new research tools for use by the neuroscience research community within universities and in the private setting.
Basic neurobiologists: The large gene expression data sets we are producing will provide insights into other aspects of basic neurobiology. For example, it will be of value to those researchers interested in analysing sex differences in transcript expression. Using this data it will be possible to improve our understanding of the basis of well recognised differences in the incidence, presentation and response to treatment of many neurological disorders. This could in turn contribute to the drive towards individualised patient assessment and care.
Bioinformaticians & statistical geneticists: The raw genotyping, exome and RNA sequencing data will be used by statistical genetics and bioinformatics wishing to test and develop new statistical and analytical methods. In particular, the existence of paired exome sequencing and SNP array data will allow researchers to objectively test and improve methods for the imputation of genetic data. Therefore, we will directly contribute to one of the MRC's stated aims, the training of more researchers and clinicians in bioinformatics.
Charities & patient groups: The discovery of genetic risk variants for PD and AD represent one of the most significant steps forward in the understanding of these diseases in the last 10 years. Therefore, they are hugely important to patients and carers who desperately want to see progress in the diagnosis and treatment of their diseases. From our own experience of hosting visits for Parkinson's Disease UK, Alzheimer's Research UK and the Michael J Fox Foundation, we recognise the importance of engaging with patients and communicating the findings generated from our research in order to maintain hope, create novel resources and improve the uptake of clinical trials.
Organisations
- University College London (Lead Research Organisation)
- Pitié-Salpêtrière Hospital (Collaboration)
- National Center for Biotechnology Information (NCBI) (Collaboration)
- UNIVERSITY OF EDINBURGH (Collaboration)
- UNIVERSITY OF LIVERPOOL (Collaboration)
- German Centre for Neurodegenerative Diseases (Collaboration)
Publications
Adams HH
(2016)
Novel genetic loci underlying human intracranial volume identified through genome-wide association.
in Nature neuroscience
Altmann A
(2020)
A comprehensive analysis of methods for assessing polygenic burden on Alzheimer's disease pathology and risk beyond APOE.
in Brain communications
Andersen MS
(2021)
Heritability Enrichment Implicates Microglia in Parkinson's Disease Pathogenesis.
in Annals of neurology
Arber C
(2019)
Amyloid precursor protein processing in human neurons with an allelic series of the PSEN1 intron 4 deletion mutation and total presenilin-1 knockout.
in Brain communications
Bandres-Ciga S
(2020)
Large-scale pathway specific polygenic risk and transcriptomic community network analysis identifies novel functional pathways in Parkinson disease
in Acta Neuropathologica
Bandres-Ciga S
(2019)
The Genetic Architecture of Parkinson Disease in Spain: Characterizing Population-Specific Risk, Differential Haplotype Structures, and Providing Etiologic Insight
in Movement Disorders
Bandres-Ciga S
(2019)
Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis.
in Annals of neurology
Bandres-Ciga S
(2019)
The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease.
in Movement disorders : official journal of the Movement Disorder Society
Barber IS
(2017)
Mutation analysis of sporadic early-onset Alzheimer's disease using the NeuroX array.
in Neurobiology of aging
Benitez DP
(2021)
Knock-in models related to Alzheimer's disease: synaptic transmission, plaques and the role of microglia.
in Molecular neurodegeneration
Bettencourt C
(2014)
Insights from cerebellar transcriptomic analysis into the pathogenesis of ataxia.
in JAMA neurology
Billingsley KJ
(2019)
Mitochondria function associated genes contribute to Parkinson's Disease risk and later age at onset.
in NPJ Parkinson's disease
Blauwendraat C
(2021)
Investigation of Autosomal Genetic Sex Differences in Parkinson's Disease.
in Annals of neurology
Blauwendraat C
(2019)
Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and a-synuclein mechanisms.
in Movement disorders : official journal of the Movement Disorder Society
Blauwendraat C
(2017)
NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases.
in Neurobiology of aging
Blauwendraat C
(2020)
Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia.
in Brain : a journal of neurology
Botía JA
(2017)
An additional k-means clustering step improves the biological features of WGCNA gene co-expression networks.
in BMC systems biology
Brown EE
(2021)
Analysis of DNM3 and VAMP4 as genetic modifiers of LRRK2 Parkinson's disease.
in Neurobiology of aging
Chaudhury S
(2019)
Alzheimer's disease polygenic risk score as a predictor of conversion from mild-cognitive impairment.
in Translational psychiatry
Chaudhury S
(2019)
Correction: Alzheimer's disease polygenic risk score as a predictor of conversion from mild-cognitive impairment.
in Translational psychiatry
Chelban V
(2021)
Spastic paraplegia preceding PSEN1-related familial Alzheimer's disease.
in Alzheimer's & dementia (Amsterdam, Netherlands)
Chelban V
(2017)
Mutations in NKX6-2 Cause Progressive Spastic Ataxia and Hypomyelination.
in American journal of human genetics
Chen Z
(2021)
Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage.
in Nature communications
COVID-19 Host Genetics Initiative
(2021)
Mapping the human genetic architecture of COVID-19.
in Nature
Cruchaga C
(2014)
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease.
in Nature
Cruchaga C
(2014)
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease.
in Nature
D'Souza H
(2020)
Differential Associations of Apolipoprotein E e4 Genotype With Attentional Abilities Across the Life Span of Individuals With Down Syndrome.
in JAMA network open
Darwent L
(2017)
Mutations in TYROBP are not a common cause of dementia in a Turkish cohort
in Neurobiology of Aging
Desikan RS
(2017)
Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score.
in PLoS medicine
Escott-Price V
(2019)
Genetic analysis suggests high misassignment rates in clinical Alzheimer's cases and controls.
in Neurobiology of aging
Espuny-Camacho I
(2017)
Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.
in Neuron
Feleke R
(2021)
Cross-platform transcriptional profiling identifies common and distinct molecular pathologies in Lewy body diseases.
in Acta neuropathologica
Fernández-Santiago R
(2019)
SNCA and mTOR Pathway Single Nucleotide Polymorphisms Interact to Modulate the Age at Onset of Parkinson's Disease.
in Movement disorders : official journal of the Movement Disorder Society
Ferrari R
(2014)
Assessment of common variability and expression quantitative trait loci for genome-wide associations for progressive supranuclear palsy.
in Neurobiology of aging
Ferrari R
(2017)
Effects of Multiple Genetic Loci on Age at Onset in Frontotemporal Dementia.
in Journal of Alzheimer's disease : JAD
Ferrari R
(2019)
Genetics and molecular mechanisms of frontotemporal lobar degeneration: an update and future avenues.
in Neurobiology of aging
Fogh I
(2014)
A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis.
in Human molecular genetics
Forabosco P
(2013)
Insights into TREM2 biology by network analysis of human brain gene expression data.
in Neurobiology of aging
Gagliano SA
(2016)
Genomics implicates adaptive and innate immunity in Alzheimer's and Parkinson's diseases.
in Annals of clinical and translational neurology
García-Ruiz S
(2021)
CoExp: A Web Tool for the Exploitation of Co-expression Networks
in Frontiers in Genetics
Glass D
(2013)
Gene expression changes with age in skin, adipose tissue, blood and brain
in Genome Biology
Guelfi S
(2020)
Regulatory sites for splicing in human basal ganglia are enriched for disease-relevant information.
in Nature communications
Guelfi S
(2019)
Transcriptomic and genetic analyses reveal potential causal drivers for intractable partial epilepsy.
in Brain : a journal of neurology
Guerreiro R
(2019)
Heritability and genetic variance of dementia with Lewy bodies.
in Neurobiology of disease
Guven G
(2019)
Peripheral GRN mRNA and Serum Progranulin Levels as a Potential Indicator for Both the Presence of Splice Site Mutations and Individuals at Risk for Frontotemporal Dementia.
in Journal of Alzheimer's disease : JAD
| Description | Attachment with Genomics England |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Joint Lead for Bioinformatics in Neurology GeCIP |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Description | EU Joint Programme Grant |
| Amount | € 530,000 (EUR) |
| Organisation | JPND Research |
| Sector | Academic/University |
| Country | Global |
| Start | 01/2014 |
| End | 01/2017 |
| Description | Project Grant |
| Amount | £1,000,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2010 |
| End | 03/2013 |
| Description | Project Grant |
| Amount | £1,300,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2013 |
| End | 03/2016 |
| Description | Wellcome Biomedical Resource Grant |
| Amount | £200,000 (GBP) |
| Organisation | Wellcome Trust |
| Department | Wellcome Trust Bloomsbury Centre |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2016 |
| End | 10/2019 |
| Title | A web-based tool for quality control of eQTL data |
| Description | This is a web-based tool to allow users to check whether reported eQTLs may be due to systematic errors arising from the presence of polymorphisms within expression microarray probes. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2012 |
| Provided To Others? | Yes |
| Impact | This is currently being used by our collaborators based in the NIH, but will soon be made publicly available. It has resulted in the identification of a significant number of false positive results. |
| Title | A web-based tool for eQTL analysis and expression profiles |
| Description | We have created a web-based tool to allow researchers to access the eQTL data we have generated and expression profiles in human brain. |
| Type Of Material | Biological samples |
| Year Produced | 2013 |
| Provided To Others? | Yes |
| Impact | This is presently being used by groups within KCL and UCL to follow up GWAS results. |
| Title | Database on genetic variation in neurologically normal individuals over the age of 60 years old |
| Description | I contributed to the HEXdatabase which provides information on genetic variation in individuals with no evidence of a neurological disorder. |
| Type Of Material | Biological samples |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | This tool will be released on the Alzform website. |
| Title | Genome-wide gene expression in 10 human brain regions |
| Description | This is a database of exon-specific gene expression generated from over 800 RNA samples extracted from post-mortem human brain tissue. |
| Type Of Material | Biological samples |
| Provided To Others? | No |
| Impact | This collection of data when released will provide researchers working in the field of neuroscience comprehensive imformation on the expression of all genes within multiple human brain regions. |
| Title | Human genome expression database |
| Description | Gene expression database. http://caprica.genetics.kcl.ac.uk:51519/BRAINEAC/ |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Year Produced | 2010 |
| Provided To Others? | Yes |
| Impact | It has been accessed several thousand times and data from it incorporated into at least 100 publications |
| URL | http://smarturl.it/braineac |
| Title | StemBANCC |
| Description | Stem cell biobank. Freely available. |
| Type Of Material | Cell line |
| Year Produced | 2012 |
| Provided To Others? | Yes |
| Impact | This has been a successful application and many drug companies are using stem cell lines supplied by our group |
| URL | http://stembancc.org |
| Description | Collection and analysis of control human post-mortem brain tissue |
| Organisation | University of Edinburgh |
| Department | Neuropathology Unit |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have supplied our collaborators with information regarding the degree of RNA preservation within banked control human brain tissue. |
| Collaborator Contribution | This collaboration has allowed to collect high quality control human brain tissue for analysis. |
| Impact | This collaboration has allowed us to build a database of exon-specific gene expression in multiple human brain regions. |
| Start Year | 2009 |
| Description | PARK7 gene structure and expression |
| Organisation | University of Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expression and RNAseq data and data interpretation relating to PARK7 expression in human brain |
| Collaborator Contribution | Expertise regarding the structure and function of PARK7 |
| Impact | Manuscript in preparation |
| Start Year | 2012 |
| Description | The International Parkinson Disease Genomics Consortium |
| Organisation | German Centre for Neurodegenerative Diseases |
| Country | Germany |
| Sector | Public |
| PI Contribution | This is a hugem consortium. WE are founder members. WE help manage the consortium, we obtain grant funds for it and we contribute patient samples and data |
| Collaborator Contribution | They contribute in the same way we do |
| Impact | Huge number of publications: too many to list. Genetics, Gene expression and Neurology |
| Start Year | 2007 |
| Description | The International Parkinson Disease Genomics Consortium |
| Organisation | Pitié-Salpêtrière Hospital |
| Country | France |
| Sector | Hospitals |
| PI Contribution | This is a hugem consortium. WE are founder members. WE help manage the consortium, we obtain grant funds for it and we contribute patient samples and data |
| Collaborator Contribution | They contribute in the same way we do |
| Impact | Huge number of publications: too many to list. Genetics, Gene expression and Neurology |
| Start Year | 2007 |
| Description | Whole genome expression analysis for the assessment of hESC-derived neuronal maturation |
| Organisation | University of Edinburgh |
| Department | Centre for Clinical Brain Sciences (CCBS) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I have performed the expression and splicing analysis of these samples. |
| Collaborator Contribution | They have provided samples of hESCs, neural precursors and hESc-derived neurons. They have also provided expertise on the process of neural differentiation. |
| Impact | We currently have a paper in submission to Human Molecular Genetics. This collaboration is multidisciplinary with specialist cell and developmental biologists. |
| Start Year | 2011 |
| Description | Whole genome expression in iPS-derived neurons in health and disease |
| Organisation | University of Edinburgh |
| Department | MRC Centre for Regenerative Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have performed the analysis of geen expression and splicing in these samples. |
| Collaborator Contribution | It has resulted in the provision of unique samples for the investigation of the impact of specific genetic mutations known to cause Parkinson's Disease on gene expression. |
| Impact | This collaboration has resulted in a publication in Nature Communications and also prompted the submission of a successful project grant to the Alzheimer's Research Trust (£30,000). This is a project using the skills and knowledge of specialist cell biologists with my own technical skills in expression analysis. |
| Start Year | 2011 |
| Description | eQTL analysis in control human cerebellum and frontal cortex |
| Organisation | National Center for Biotechnology Information (NCBI) |
| Country | United States |
| Sector | Public |
| PI Contribution | We have provided a considerable amount of processed gene expression data. |
| Collaborator Contribution | This collaboration has allowed us to increase the power of our study by increasing the n number and has provided us with technical expertise regarding the analysis of eQTL data. |
| Impact | We have a publication in submission as a direct result of this study. |
| Start Year | 2010 |
| Description | "Alpha-synuclein & Parkinson's disease Conference: lessons from the past 20 years" Barcelona |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker to The University of Barcelona Medical School - Talk title: "Genetics of synucleinopathies" |
| Year(s) Of Engagement Activity | 2017 |
| Description | "Do Genetic Findings Converge on Discrete Pathophysiological Pathways?" invited lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 12th National Alzheimer Disease Conference, Virtual Eskisehir Turkey |
| Year(s) Of Engagement Activity | 2022 |
| Description | "Genomics in Neurodegenerative disease -- what are we up to" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited Lecture as HKUST IAS fellow, Hong Kong |
| Year(s) Of Engagement Activity | 2019 |
| Description | "Neurogenetic Foundations of Movement Disorders - The Key to Cure?" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Keynote Lecture |
| Year(s) Of Engagement Activity | 2019 |
| Description | "The Genetics of the Dementias" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited teaching lecture at Queen Square on MSc Human Genetics course 2018-19 |
| Year(s) Of Engagement Activity | 2019 |
| Description | 2017 EMBO conference on "Mechanisms of Neurodegeneration" at the EMBL Advanced Training Centre (ATC) in Heidelberg |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk at EMO - Genomics of Neurodegeneration |
| Year(s) Of Engagement Activity | 2017 |
| Description | 24th IUBMB Congress & 15th FAOBMB Congress - [IUBMB Seoul 2018] Invitation to be a Plenary Speaker |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited Plenary speaker - Talk title: 'Genomic analysis of late onset neurodegenerative diseases' |
| Year(s) Of Engagement Activity | 2018 |
| Description | 2nd Regional DBS meeting - 'Deep brain stimulation: New Horizons in Neurology and Psychiatry' Westin Zagreb hotel. Zagreb, Croatia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited speaker - talk: Genomic analysis of neurological diseases and possible implications on society |
| Year(s) Of Engagement Activity | 2017 |
| Description | 2nd international Taiwanese Congress of Neurology and 2017 Annual meeting of Taiwan Neurological Society |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited speaker - Talk title: Current Advance in Genetic Understanding of Parkinson's Disease |
| Year(s) Of Engagement Activity | 2017 |
| Description | 5th Venusberg Meeting, Bonn |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited speaker to the meeting talk title: "The genomics of neurodegeneration" |
| Year(s) Of Engagement Activity | 2017 |
| Description | AD research and future interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Virtual Interview Yasemin Saplakoglu Biology Staff Writer Quanta Magazine C: (347) 585-9167 New York, New York |
| Year(s) Of Engagement Activity | 2022 |
| Description | Advances in Alzheimer's Disease |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker - The 10th Xiangya International Symposium of the Clinical and Basic Research on Neurodegenerative Disorders, China |
| Year(s) Of Engagement Activity | 2019 |
| Description | Alzheimer's Association International Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Mouseac Project: A Genome Wide Expression Analysis of Murine Models of Dementia According to Age and Brain Region Signifies the Importance of Microglial Pathways |
| Year(s) Of Engagement Activity | 2018 |
| Description | Alzheimer's disease pathogenesis: what do we know and why have clinical trials failed |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Invited public lecture |
| Year(s) Of Engagement Activity | 2019 |
| Description | Amyloid hypoithesis.. what was right and what was wrong Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | 6th Rijeka Forum on Neurodegenerative Disease Croatian Academy of Sciences and Arts Department of Biomedical Sciences in Rijeka |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://neurolab.uniri.hr/?page_id=24#:~:text=The%206th%20Rijeka%20Forum%20of,of%20the%20amyloid%20c... |
| Description | Aß hypothesis, AD genetics" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited lecture - Wenner-Gren Center (Sveavägen 166), Stockholm, Sweden symposium : "Amyloid diseases: from biochemistry to clinical applications" |
| Year(s) Of Engagement Activity | 2019 |
| Description | Boston Neuroimmunology/AD Think Tank, Beauport Hotel |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | What are the genetics of AD teaching us about the neuroimmune axis in neurodegeneration? |
| Year(s) Of Engagement Activity | 2018 |
| Description | Brain Prize Lectures Royal Danish Academy of Science and Letters in Copenhagen |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Supporters |
| Results and Impact | Brain Prize Lecture - "Genomic Analysis outlines the pathogenesis of Alzheimers´s disease" |
| Year(s) Of Engagement Activity | 2018 |
| Description | Crispr Talk - John and Selina |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Lecture Royal London Hospital |
| Year(s) Of Engagement Activity | 2019 |
| Description | Dementias - Invited Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | "Preserving the Brain" is a forum on neurodegenerative diseases presented in September and October 2022, as the fourth phase of "Human Brains," Fondazione Prada's neuroscience project. Realized in collaboration with thirteen of the most prestigious international neuroscience institutes and universities, "Human Brains: Preserving the Brain - Forum on Neurodegenerative Diseases" comprises an exhibition (16 September - 10 October 2022) and a conference (6 and 7 October 2022) at Fondazione Prada's Milan premises and online. "Preserving the Brain" aims to stimulate an open and critical exchange between international scientists and experts on neurodegenerative diseases, such as Alzheimer's, Parkinson's, Amyotrophic lateral sclerosis and Multiple sclerosis, which are widely spread and as yet incurable. The forum participants include researchers, patient associations, and representatives of health care institutions and the pharmaceutical and biotechnology industries. They will debate the current state of knowledge of these diseases and the tools currently used to fight them, while also seeking to identify lacunae in the search for possible therapies, and jointly defining priorities and strategies to sustain scientific research. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.fondazioneprada.org/project/human-brains-preserving-the-brain/?lang=en#:~:text=Realized%... |
| Description | Dementias - Invited Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | https://www.fondazioneprada.org/project/human-brains-preserving-the-brain/?lang=en#:~:text=Realized%20in%20collaboration%20with%20thirteen,2022)%20at%20Fondazione%20Prada's%20Milan invited Lecture |
| Year(s) Of Engagement Activity | 2022 |
| Description | Department of Pharmacology, Mansfield Road, Oxford |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Pharmacology, Anatomical Neuropharmacology and Drug Discovery Seminars - Talk title: Genomics of neurodegenerative diseases |
| Year(s) Of Engagement Activity | 2018 |
| Description | Epidemiology of Alzheimer's Disease and Related Disorders |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited Keynote speaker on teaching course at Bordeaux School of Neuroscience |
| Year(s) Of Engagement Activity | 2019 |
| Description | ExCel - Humans Theatre New Scientist Live |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | When will we cure Alzheimer's and Parkinson's? |
| Year(s) Of Engagement Activity | 2017 |
| Description | Faculty of Medicine, University of Iceland Vatnsmyrarvegur 16 101 Reykjavik - Iceland |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Distinguished speakers series |
| Year(s) Of Engagement Activity | 2017 |
| Description | Failures in Damage Response Underlie Late Onset Neurodegenerative Diseases and Explain the Relationship Between Pathology and Genetics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Virtual UK-Russia online forum on Neurodegenerative Diseases and Brain Plasticity Requested by Alena Gureva | Science and Innovation Officer, UK Science & Innovation Network in Russia British Embassy Moscow | Smolenskaya Naberezhnaya, 10 | Moscow 121099 |
| Year(s) Of Engagement Activity | 2022 |
| Description | Francis Crick Institute - main auditorium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Crick Lecture - Genomic analysis of neurodegenerative disease |
| Year(s) Of Engagement Activity | 2018 |
| Description | Genetic Analysis of Neurodegeneration Implicates a Failure of Damage Response Pathways Pre-recorded and live Q&A |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Neural Pathways Underlying Brain Function and Pathologies Organized by: Nature Portfolio, Chinese Institute for Brain Research, Beijing (CIBR) Supported by: Beijing Municipal Science & Technology Commission, Administrative Committee of Zhongguancun This event aims to bring together Chinese and international researchers at the forefront of brain science to share their recent achievements in helping to push our understanding forward under both normal and pathological conditions. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://neuralpathways.natureresearch.cn/ |
| Description | Genetic analysis of late onset degenerative diseases implicates failures of damage response |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Speaker invitation and Announcement of The Brain Prize Awardee 2019 Copenhagen, Denmark |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genetics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Supporters |
| Results and Impact | Invited Lecture Weston's meeting - 50th Year Anniversary Symposium, 33 Queen Square |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genetics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Supporters |
| Results and Impact | Wolfson final symposium - Institute of Child Health London |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genetics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Lecture - Wolfson Institute for Biomedical Research (WIBR) mini-symposium - Sainsbury Wellcome Centre London |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genetics and neurodegeneration |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited to present a teaching lecture to the Basal Ganglia Club Gilliatt Lecture Theatre Queen Square by Dr Amit Batla MBBS, MA (Clin Ed), MD (Med), DM (Neurology), FRCP Clinical Associate Professor (teaching), Department of Clinical and Movement Neuroscience, UCL Queen Square Institute of Neurology |
| Year(s) Of Engagement Activity | 2022 |
| Description | Genetics in neurodegenerative disease |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited lecture at 2019 International Conference of Korean Dementia Association, (IC-KDA 2019) Seoul |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genetics in neurodegenerative diseases |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited teaching to PhD students on Biomarkers for neurodegenerative diseases PhD course |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genetics of Alzheimer's |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited lecture at Hong Kong University of Science and Technology ShenZhen branch |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genetics of Alzheimer's and other neuro-degenerative disease |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited Lecture - China National Genebank - Jinsha Road, Dapeng New District, Shenzhen |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genetics of Dementias |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Lecture XXIV World Congress of Neurology, Dubai - AE |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genetics of Neurodegeneration |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited Lecture at Lisbon AD/PD meeting |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genomic Analysis of Neurodegeneration |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Zoom Teaching lecture - invited by Dr Kerri Kinghorn ucl lectures Neurological diseases module GENE003 |
| Year(s) Of Engagement Activity | 2022 |
| Description | Genomic analysis of neurodegenerative diseases |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited lecture Scientific Talk (to senior scientists) Odense University Hospital, Denmark |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genomic analysis of the mechanisms of neurodegenerative disease in Denmark to PhD students |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Teaching Lecture to PhD students in neuroscience at the NeuroGrad Winter School, Copenhagen |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://neurograd.ku.dk/neurograd-winter-school/ |
| Description | Genomic clues to neurodegenerative disease mechanisms |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Brain Prize Special Lecture/ keynote lecture at ECNP Congress in Copenhagen |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genomics of Neurodegeneration |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited lecture - 3rd Rijeka Forum on Neurodegenerative diseases, Croatia Rijeka |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genomics of neurodegenerative disease |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Keynote speaker FENS The Serbian Neuroscience Society. with the Neuroscience societies of Romania and Turkey. Belgrade Serbia. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Grand Rounds Invitation: Albert Einstein College of Medicine - Montefiore Medical Center |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Grand Rounds Invitation: Albert Einstein College of Medicine - Montefiore Medical Center talk entitled: Genomic analysis of neurodegenerative diseases implicates failures of damage clearance with Q&A |
| Year(s) Of Engagement Activity | 2021 |
| Description | Hong Kong Student Association of Neuroscience (HKSAN) - Neuroscience: Past, Present, Future Symposium of 1st Asia-Pacific Neuroscience Student Congress and HKSAN 2nd Annual Conference (APNSC-HKSAN) 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited speaker to Hong Kong Student Association of Neuroscience (HKSAN) - Neuroscience: Past, Present, Future Symposium of 1st Asia-Pacific Neuroscience Student Congress and HKSAN 2nd Annual Conference (APNSC-HKSAN) 2021. Talk entitled: Whole genome analysis of neurodegeneration |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.hksaneuroscience.org/apnsc-hksan-programme |
| Description | Inaugural Baillieu Myer Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Inaugural Baillieu Myer Lecture, in honour of contribution to medical research, in particular dementia research |
| Year(s) Of Engagement Activity | 2019 |
| Description | Institute of Neurology seminar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | The Fifteenth Pewterers' Lecture "What is the basis of selective vulnerability in neurodegenerative diseases?" |
| Year(s) Of Engagement Activity | 2018 |
| Description | Interview with USA Today Health Reporter Ken Alltucker |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with USA Today Health Reporter Ken Alltucker about results of new Alzheimer drug trials |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited Interview/Q&A - Biomarkers for neurodegenerative diseases |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Cars and Scientists short film series, now supported by Jackie Stewart's charity Race Against Dementia |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.raceagainstdementia.com/research/accelerating-research/ |
| Description | Invited Round table public talk |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited public round table - Brain Prize Evening - Lundbeck - BNA Festival, The Convention Centre Dublin |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited Speaker - 5th RIJEKA FORUM ON NEURODEGENERATIVE DISEASES NEURODEGENERATIVE DISEASES: TOWARD THERAPY |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker to 5th RIJEKA FORUM ON NEURODEGENERATIVE DISEASES NEURODEGENERATIVE DISEASES: TOWARD THERAPY Talk entitled: Genetic analysis of decline of disease rate |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://uniri.hr/wp-content/uploads/2021/11/Simpozij-49_finalno.pdf |
| Description | Invited Speaker 30th Adler Symposium on Alzheimer's Disease |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Supporters |
| Results and Impact | Goal of the Symposium The 30th anniversary Adler Symposium will focus on issues that are directly relevant to Alzheimer's disease (AD) or on therapies for other disorders that may impact AD. There are four major themes: 1) AD diagnostics and therapeutics; 2) Non-AD therapies that could impact our thinking about AD; 3) Role of genetics, epigenetics, and innate immunity in AD; 4) Brain cell senescence and systemic factors that influence neurodegeneration. The overall format of the meeting should also provide plentiful opportunities for informal interchanges among all the speakers and participants. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Invited lecture - Alector Seminar and round table |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Invited speaker entitled: Genomic analysis of neurodegeneration implicates proteostasis as the key problem in late-onset disease followed by round-table discussions |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited speaker - The Genetics Society of Korea |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Invited Plenary Speaker to The Genetics Society of Korea |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.illumina.com/content/illumina-marketing/spac/en_AU/events/conferences/2021/icgsk-2021.ht... |
| Description | Invited speaker NIH Clinical Neuroscience Grand Rounds Main Lecture Speaker |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker talk entitled: Genomic Analysis of the Major Neurodegenerative Diseases - NIH Clinical Neuroscience Grand Rounds with Q&A |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited speaker to 45th FEBS Congress |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk entitled: Failures in Protein Clearance Partly Underlie Late Onset Neurodegenerative Diseases and Link Pathology to Genetic Risk at 45th FEBS conference |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://2021.febscongress.org/ |
| Description | Invited speaker to The 15th International Conference on Alzheimer's & Parkinson's Diseases (AD/PD) Eisai-sponsored Satellite symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk entitled:The biological and genetic evidence of the Aß pathway The 15th International Conference on Alzheimer's & Parkinson's Diseases (AD/PD) Eisai-sponsored Satellite symposium |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://adpd2021.kenes.com/ |
| Description | Invited talk to the Elderly |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Invited speaker at Chinese Dementia Meeting at Community Elder Center at Hebei, China |
| Year(s) Of Engagement Activity | 2019 |
| Description | Keynote Presentation Molecular Neurodegeneration and Therapeutic Approaches course: Genomic analysis of neurodegeneration |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Keynote Presentation Molecular Neurodegeneration and Therapeutic Approaches course - Genomic analysis of neurodegeneration Wellcome Genome Campus in person Hinxton, Cambridgeshire |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://coursesandconferences.wellcomeconnectingscience.org/event/molecular-neurodegeneration-and-th... |
| Description | Keynote Speaker of the Karolinska Institute StratNeuro Neuroscience Symposium 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited speaker - talk title: Genomics of neurodegeneration |
| Year(s) Of Engagement Activity | 2018 |
| Description | Keynote at CTAD 2017 10th edition of Clinical Trials on Alzheimer's Disease (CtaD2017) held in Boston, MA - USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Genetic Aspects In Clinical Trials |
| Year(s) Of Engagement Activity | 2017 |
| Description | Keystone Conference in Colorado - New Frontiers in Neuroinflammation: What Happens When CNS and Periphery Meet? |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited speaker - Talk title: Genetics in Neurodegenerative Diseases |
| Year(s) Of Engagement Activity | 2018 |
| Description | MRC/BTR event - Neurosciences and Brain Tumour Research: Joining Forces for Greater Impact BEIS Conference Centre, 1 Victoria Street, London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited speaker - Plenary talk |
| Year(s) Of Engagement Activity | 2018 |
| Description | Meet the Professors |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited Round table public talk |
| Year(s) Of Engagement Activity | 2019 |
| Description | Meeting EMBO - Basal Life |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Plenary session 4 Genes to disease and therapies - René Bernards, Botond Roska, Christine Petit, John Hardy |
| Year(s) Of Engagement Activity | 2017 |
| Description | Neanderthals - talk for The National Trust |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Lecture in response to a request to talk to a regional National Trust membership |
| Year(s) Of Engagement Activity | 2019 |
| Description | Opening lecture: Alzheimer's disease: a personal view on early diagnosis and treatment |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited Lecture - XVIII Teófilo Hernando's International Summer School of Pharmacology Frontier Biomarkers and Drug Discovery for the Early Diagnosis and Treatment of Alzheimer's Disease |
| Year(s) Of Engagement Activity | 2019 |
| Description | Pan-London regional teaching day for all the neurology registrars in London |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Pan-London regional teaching day for all the neurology registrars in London - talk - Genomics and neurology |
| Year(s) Of Engagement Activity | 2017 |
| Description | Parkinson's Disease Gordon Research Conference. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Parkinson's Disease Genetics and Systems Biology- Discussion Leader |
| Year(s) Of Engagement Activity | 2017 |
| Description | Progress in the genomic analysis of neurodegeneration |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Lecture to the department of Neurodegenerative Disease as an update on work in progress |
| Year(s) Of Engagement Activity | 2019 |
| Description | Promoting Healthy Brain Aging and Preventing Dementia: Research and Translation, taking place from the Banff Centre for Arts and Creativity in Banff, Alberta |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | keynote address - Genomic analysis of neurodegeneration |
| Year(s) Of Engagement Activity | 2018 |
| Description | Rethinking PD: From a Single Disease to Multiple Diseases:: Genetics, Epigenetics and Environmental Factors |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited Lecture by The Preuss Foundation Seminar on State of the Art Parkinson's Disease Research ~ La Jolla, California |
| Year(s) Of Engagement Activity | 2019 |
| Description | Second Rijeka Forum for neurodegenerative diseases 2018 Croatia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited Speaker - Talk title: Genomic analysis of neurodegenerative diseases and possible implications on society |
| Year(s) Of Engagement Activity | 2018 |
| Description | Session 4 - Panel discussion: 'The Future of Neuroscience' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited Lecture - UCL Neuroscience Symposium 10th Anniversary, UCL Institute of Education |
| Year(s) Of Engagement Activity | 2019 |
| Description | Skype 2 hour lecture to students |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited Teaching Lecture to Masters Students "Athens International Master's Programme in Neurosciences" University of Athens Department of Biology |
| Year(s) Of Engagement Activity | 2019 |
| Description | Stanford University - Brain Rejuvenation Mini-symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited speaker Stanford University - Brain Rejuvenation Mini-symposium |
| Year(s) Of Engagement Activity | 2018 |
| Description | Talk for the Cardiff Gene Park to sixthformers |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | The talk sparked discussion following the event No notable impact yet |
| Year(s) Of Engagement Activity | 2014 |
| Description | Tau 2020 Conference in Washington |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invitation to Present latest updates at Tau 2020 - On behalf of the Alzheimer's Association, the Rainwater Foundation, and CurePSP to move Tau research forward |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.alz.org/tau2020/overview.asp |
| Description | Teaching lecture UCL |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Genetics of Neurological diseases module GENE003 UCL |
| Year(s) Of Engagement Activity | 2021 |
| Description | Teaching lecture UCL - The importance of genetics and molecular biology in neurodegenerative diseases |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Teaching lecture - for the Clinical Neuroscience MSc 33 QS Lecture Theatre |
| Year(s) Of Engagement Activity | 2022 |
| Description | The 12th World Congress on Controversies in Neurology (CONy), Warsaw, Poland |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited speaker - talk title: Insights from genomic analysis of neurodegeneration |
| Year(s) Of Engagement Activity | 2018 |
| Description | The Roy M. Huffington Distinguished Lecture at Baylor College of Medicine |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited Speaker - Genomic Analysis of Neurodegeneration |
| Year(s) Of Engagement Activity | 2017 |
| Description | The importance of genetics and molecular biology in neurodegenerative diseases |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited teaching UCL - Basic neuroscience and investigation of Nervous system - CLNE0009 Queen Square |
| Year(s) Of Engagement Activity | 2019 |
| Description | The importance of genetics and molecular biology in neurodegenerative diseases |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Invitation to Lecture on MRes Translational Neuroscience programme - 7 Queen Square |
| Year(s) Of Engagement Activity | 2019 |
| Description | The role of genetics and genetic testing in PD |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Lecture at World Parkinson Coalition 2019 Kyoto, Japan |
| Year(s) Of Engagement Activity | 2019 |
| Description | University Menéndez Pelayo, in the course XVI International School of Pharmacology < |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Teaching session - Understanding Brain Diseases - Alzheimer's Disease |
| Year(s) Of Engagement Activity | 2017 |
| Description | University of Manchester 2nd Lecture Series |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | 'Nanotechnology in Neurology and Neurosciences - Keynote Lecture |
| Year(s) Of Engagement Activity | 2017 |
| Description | Visit and seminar Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taiwan |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker - Talk title: Genomic clues as to the reasons for selective vulnerability in neurodegenerative disease |
| Year(s) Of Engagement Activity | 2017 |
| Description | Visit to Columbia University New York |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Advances in Precision Medicine: Genetics - Dr Hardy focuses on the genetic analysis of complex traits related to neurological disease, and in population genetics to understand the underlying genetics of a disorder so he can work with those making cellular and animal models of the disease to help, both in the understanding of disease mechanisms and to help in the search for treatments |
| Year(s) Of Engagement Activity | 2017 |
| Description | Visit to First AoE IAB Meeting - Hong Kong HKUST Jockey Club Institute for Advanced Study |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker - IAS Distinguished Lecture - Genomic analysis of neurodegenerative disorders |
| Year(s) Of Engagement Activity | 2018 |
| Description | Visit to Japan University of Tokyo |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Alzheimer's Scientific Roundtable |
| Year(s) Of Engagement Activity | 2018 |
| Description | Visit to Lecture Theatre 2 Southampton General Hospital |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | PDA Christmas Lecture Genomic analysis of neurodegenerative diseases suggests that failure in damage response is a critical issue |
| Year(s) Of Engagement Activity | 2018 |
| Description | Visit to Lundbeck Institute Denmark |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Why has amyloid therapy not worked; Genomics of neurodegeration |
| Year(s) Of Engagement Activity | 2018 |
| Description | Visit to The Medical School Queen's Medical Centre Nottingham NG7 2UH |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Life Sciences Annual Lecture - 12 July 2018 - Genomics and neurodegenerative disease |
| Year(s) Of Engagement Activity | 2018 |
| Description | Visit to The Rockefeller University 1230 York Ave. New York, NY 10065 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | The Rockefeller University Friday Lecture - Genomic analysis of Alzheimer's disease and other neurodegenerative disorders |
| Year(s) Of Engagement Activity | 2018 |
| Description | Visit to Yale University School of Medicine |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 2018 Sackler Lectureship at Yale |
| Year(s) Of Engagement Activity | 2018 |
| Description | Webinar Series Lecture Neuroscience in Africa |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The Genetics of Parkinson's Disease: Understanding the Differences between European & African Populations. to raise awareness in Africa |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.youtube.com/watch?v=Lf6woi9zKCs |
| Description | Website - Alzforum |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview has sparked online comments Requests for data sharing |
| Year(s) Of Engagement Activity | 2014 |
| Description | Website - SAFARI |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | The report has sparked interest in our data set and resources I have been e-mailed for specific data |
| Year(s) Of Engagement Activity | 2014 |
| Description | What is the relationship between mendelian disease and sporadic disease (and how does the environment fit in?) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Third UCL Queen Square Motor Neuron Disease Centre International Symposium Lecture Theatre, 33 QS Invited KEYNOYE Speaker |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.ucl.ac.uk/ion/events/2022/sep/third-ucl-queen-square-motor-neuron-disease-centre-virtual... |
| Description | Where is genetics leading us: The future of genetics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | UCL Teaching lecture - Neuromuscular Disease MSc/MRes Advanced genetic technologies and clinical applications module invited by David Blundred - Education Unit - Institute of Neurology |
| Year(s) Of Engagement Activity | 2022 |
| Description | Wolfson Seminar on Neurodegeneration |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | I spoke about the potential clinical use of transcriptomics in clinical practice and for the understanding of neurodegenerative disorders. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Workshop on Alzheimer's Disease and Related Disorders, FBRI Meeting, Kronberg, Germany |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Type Of Presentation | workshop facilitator |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof Hardy led the workshop. Exchange of ideas and information. Excellent feedback. Participants reported being pleased with the intellectual stimulation. |
| Year(s) Of Engagement Activity | 2015 |
| Description | invited interview |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview to discuss the latest study in the Lancet which suggests By 2050, more than 153 million people could have dementia, up from 57 million in 2019, and that more than one in 50 people in Britain will be living with dementia by 2050. Public knowledge The interview in English, around 5min, aired on BBC World TV and ran several times in full. As a reminder BBC world TV has more than 122 million viewers a week and in more than 200 countries. Their website receives more than a billion views a month |
| Year(s) Of Engagement Activity | 2022 |
| Description | invited lecture 25th National Dementia Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | presentation - Alzheimer's disease: from genetic analysis to mechanistic treatments, with Q&A Thursday 9th February |
| Year(s) Of Engagement Activity | 2023 |
| Description | invited speaker - Understanding the endosomal pathway in neurodegeneration' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Royal Society Hooke Discussion Meeting Organised by Professor Peter Cullen, Professor Peter St George-Hyslop FRS, Professor Scott Small and Dr Henne Holstege Understanding the endosomal network in neurodegeneration 21 - 22 November 2022 The Royal Society, London and online |
| Year(s) Of Engagement Activity | 2022 |
| Description | invited speaker 12th European Congress of Neuropathology |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Lecture entitled: Clues to the aetiology of neurodegenerative diseases from genomic analysis at 12th European Congress of Neuropathology |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.ecnp2020.dk/ |
| Description | talk on Genetics at McGill University in Canada |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited Lecture |
| Year(s) Of Engagement Activity | 2019 |