AMBROSIAC - A Menu for Brain Responses Opposing Stress-Induced Alterations in Cognition
Lead Research Organisation:
King's College London
Department Name: Psychological Medicine
Abstract
Diet and nutritional habits significantly impact on brain fitness, mental and cognitive health throughout life. The relative abundance of specific dietary nutrients, depending on intake, bioavailability and metabolism, affects mental health and cognitive ability via direct and indirect mechanisms that modulate neuronal function and synaptic plasticity. Optimum nutrition is a key determinant in the well-being of the healthy ageing population world-wide, as ageing is characterized by a decline in metabolism and homeostatic processes as well as age-related cognitive impairment over time, leading to functional decline and increased risk for disease. Chronic stress has been shown to negatively impact brain plasticity and cognitive performance, in particular in the ageing brain. Interestingly, the aged brain resembles the stressed brain on both behavioural and cellular levels and stress-induced cognitive alterations are likely to be more marked in the elderly. Likewise, poor nutritional habits are hypothesized to correlate with a heightened stress reactivity and susceptibility and greater cognitive decline in elderly, supporting the notion that interactions between nutritional factors and stress susceptibility represent critical determinants of cognitive performance and age-related cognitive decline.
Technical Summary
This proposal investigates how diet through stress-related mechanisms affects cognition across the lifespan using preclinical and clinical approaches. Particular focus will be on the influence of nutrition on increased susceptibility for stress-induced cognitive deficits in memory and executive functioning from adulthood to old age (aim 1) and the impact of a nutritional intervention on cognitive ability, stress vulnerability and stress perception (aim 2). Next, the molecular mechanisms by which targeted nutritional interventions can improve stress-induced vulnerabilities in cognition will be investigated using preclinical models (aim 3). Throughout the 3 aims, the gut microbiota will be investigated as a novel critical signalling mediator between nutritional intake, stress susceptibility and maintenance of cognitive health in ageing (using samples from aims 1, 2 and 3). Elucidating the cellular and molecular mechanisms and pathways through which nutrition can promote the resistance of neurons to insults and enhance mental fitness will help us to determine how best to modulate diet composition in order to attenuate stress vulnerability, reduce susceptibility to metabolic disorders, and ultimately promote brain health during healthy ageing.
Planned Impact
In line with the vision of the JPI to strengthen Europe's competiveness, AMBROSIAC aims to positively impact population health, society and the economy though influencing industry (food, pharma, biotechnology) via the project outcomes. AMBROSIAC will provide a platform to uncover the interactions between diet and targeted nutritional interventions with stress vulnerability and cognitive performance throughout life. The cooperation between several of the partners of the AMBROSIAC project is already existent, as collaborative efforts have already been initiated in the context of different research projects investigating the relationship between metabolic, nutritional and inflammatory processes and mental health, including the relationship between stress and cognition.
Organisations
- King's College London (Lead Research Organisation)
- H. Lundbeck A/S (Collaboration)
- University College London (Collaboration)
- Wellcome Trust (Collaboration)
- Newcastle University (Collaboration)
- Royal College of Surgeons in Ireland (Collaboration)
- Vall d'Hebron University Hospital (Collaboration)
- Pfizer Ltd (Collaboration)
- China Medical University Hospital (Collaboration)
- European College of Neuropsychopharmacology (ECNP) (Collaboration)
- Johnson & Johnson (Collaboration)
- Guy's and St Thomas' NHS Foundation Trust (Collaboration)
- UNIVERSITY OF EDINBURGH (Collaboration)
- Medical Research Council (MRC) (Collaboration)
- GlaxoSmithKline (GSK) (Collaboration)
- University of Barcelona (Collaboration)
- Erasmus University Rotterdam (Collaboration)
- University of Bristol (Collaboration)
- KING'S COLLEGE LONDON (Collaboration)
Publications
Estevao C
(2021)
Scaling-up Health-Arts Programmes: the largest study in the world bringing arts-based mental health interventions into a national health service.
in BJPsych bulletin
Evans R
(2022)
Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study
in The Lancet Respiratory Medicine
Fusté M
(2017)
Brain structure in women at risk of postpartum psychosis: an MRI study.
in Translational psychiatry
Genel O
(2021)
The role of AQP4 in the pathogenesis of depression, and possible related mechanisms.
in Brain, behavior, and immunity
Giacobbe J
(2021)
A systematic, integrative review of the effects of the endocannabinoid system on inflammation and neurogenesis in animal models of affective disorders
in Brain, Behavior, and Immunity
Giacobbe J
(2020)
The innate immune system and neurogenesis as modulating mechanisms of electroconvulsive therapy in pre-clinical studies.
in Journal of psychopharmacology (Oxford, England)
Giacobbe J
(2020)
The Anti-Inflammatory Role of Omega-3 Polyunsaturated Fatty Acids Metabolites in Pre-Clinical Models of Psychiatric, Neurodegenerative, and Neurological Disorders.
in Frontiers in psychiatry
Goozee R
(2017)
Effects of aripiprazole and haloperidol on neural activation during a simple motor task in healthy individuals: A functional MRI study.
in Human brain mapping
Guu TW
(2020)
A multi-national, multi-disciplinary Delphi consensus study on using omega-3 polyunsaturated fatty acids (n-3 PUFAs) for the treatment of major depressive disorder.
in Journal of affective disorders
| Title | For all sad words |
| Description | Developed in collaboration with Prof Carmine Pariante, this work is a metaphorical blood exchange. It draws from Prof Pariante's research at King's College on blood inflammation in patients with depression, Stanford University's studies that show transfusion of young blood in old mice reversed aging, and Lund University's proposition that a protein found in beetroot (incidentally an anti-inflammatory food) could substitute human blood. The artist, Lynn Lu, invited participants to tell her about a significant personal regret. Then she pricked their finger and place a drop of blood in a petri dish. In exchange, she offers them a shot of anti-inflammatory beet juice. Over the weekend, the petri dishes fill with blood "inflamed" with lament, while vials of detoxifying beetroot empty one by one. |
| Type Of Art | Performance (Music, Dance, Drama, etc) |
| Year Produced | 2017 |
| Impact | Engagement with the Science Gallery and other artistic organisation interested in using art to disseminate science |
| URL | https://lynnlu.info/for-of-all-sad-words-of-tongue-and-pen-the-saddest-are-these-it-might-have-been/... |
| Title | How do you keep sane as a creative? An interview with our new columnist, novelist Natali J Simmonds |
| Description | How do you keep sane as a creative? An interview with our new columnist, novelist Natali J Simmonds I meet Natali over Zoom from her house in the Netherlands. This is not our first online meeting - in fact, online is how I met her a couple of years ago, attending one of her Raindance film school courses on self-branding for creatives. This time it's just the two of us talking one-on-one. I'm keen to know the person behind the novelist, marketing consultant, and creative lecturer, now also a regular columnist on Inspire the Mind. "I've always been interested in mental health", she says. "All my books are about women who are struggling." But where does this struggle come from? |
| Type Of Art | Creative Writing |
| Year Produced | 2023 |
| Impact | Read by almost 50 people, promoted collaboration with writer Natali Simmonds |
| URL | https://www.inspirethemind.org/post/how-do-you-keep-sane-as-a-creative-an-interview-with-our-new-col... |
| Title | The London Riots, a Psychiatrist's Perspective |
| Description | A blog on the 2012 London Riots. In 2012, one year after the London riots, I wrote a blog for the Huffington Post UK, and longer academic paper, where I tried to interpret the terrible events of 2011 London's burning through a psychosocial perspective. As you will read in the blog, republished below, I lamented that, one year on at that time, there had been no attempt to understand the youth's suffering that had led to the protest, and that all the events were brushed under the carpet as a public order problem. Unfortunately, 10 years on and the situation has not changed: lessons have still not been learned, and there is a clear concern that the same factors operating then can make the same events happen again today. |
| Type Of Art | Creative Writing |
| Year Produced | 2021 |
| Impact | Impact on the knowledge of the public |
| URL | https://www.inspirethemind.org/blog/the-london-riots-a-psychiatrists-perspective?rq=pariante |
| Description | A Multi-National, Multi-Disciplinary Delphi Consensus Study on Using omega-3 Polyunsaturated Fatty Acids (n-3 PUFAs) for the Treatment of Major Depressive Disorder |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| URL | https://pubmed.ncbi.nlm.nih.gov/32090746-a-multi-national-multi-disciplinary-delphi-consensus-study-... |
| Description | Inspire the Mind - a digital mental health magazine |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Our digital magazine aims to reduce stigma on mental health We have reached >250K people so far, we have an average of 10K readers per month in the last months We have published >500 articles often by new and aspiring writers in science or with lived experience of mental health problems |
| URL | https://www.inspirethemind.org/ |
| Description | Lead of a new consensus statement on treatment resistant depression |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| Description | AMBROSIAC - A Menu for Brain Responses Opposing Stress-Induced Alterations in Cognition |
| Amount | £169,306 (GBP) |
| Funding ID | MR/N029488/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2016 |
| End | 08/2018 |
| Description | APIRE award |
| Amount | £24,000 (GBP) |
| Organisation | American Psychiatric Institute for Research and Education |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 01/2007 |
| End | 01/2009 |
| Description | BA Project Grant |
| Amount | £100,000 (GBP) |
| Organisation | The British Academy |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2007 |
| End | 01/2010 |
| Description | Biomedical Research Centre - Affective Disorder and Interface with Medicine Theme |
| Amount | £50,000,000 (GBP) |
| Funding ID | NIHR Biomedical Research Centre at the South London and Maudsley NHS Trust and King's College London |
| Organisation | National Institute for Health Research |
| Department | NIHR Biomedical Research Centre |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2017 |
| End | 03/2022 |
| Description | Causative mechanisms & integrative models linking early-life-stress to psycho-cardio-metabolic multi-morbidity EC - European Commission |
| Amount | € 6,000,000 (EUR) |
| Funding ID | Earlycause |
| Organisation | European Commission H2020 |
| Sector | Public |
| Country | Belgium |
| Start | 12/2019 |
| End | 12/2023 |
| Description | Distinguished Investigator Award |
| Amount | $100,000 (USD) |
| Organisation | Brain & Behaviour Research Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 07/2018 |
| End | 06/2019 |
| Description | Do steroid transporters regulate the effects of glucocorticoid hormones on the brain - in cells, in animals and humans? |
| Amount | £866,288 (GBP) |
| Funding ID | G108/603 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2004 |
| End | 12/2009 |
| Description | Does COVID-19 affect the brain?(JBCF) |
| Amount | £25,000 (GBP) |
| Funding ID | M970 |
| Organisation | Rosetrees Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2021 |
| End | 02/2022 |
| Description | EC FP7 Collaborative Project Grant (Agreement n°22963 (Mood Inflame)) |
| Amount | £484,000 (GBP) |
| Organisation | European Commission |
| Department | Seventh Framework Programme (FP7) |
| Sector | Public |
| Country | European Union (EU) |
| Start | 01/2008 |
| End | 01/2012 |
| Description | ECNP Young Researcher Grant/European College of Neuropsychopharmacology (ECNP) Studenstships |
| Amount | £80,000 (GBP) |
| Organisation | European College of Neuropsychopharmacology (ECNP) |
| Sector | Charity/Non Profit |
| Country | Netherlands |
| Start | 01/2009 |
| End | 01/2011 |
| Description | EU Patient-cEntric clinicAl tRial pLatforms |
| Amount | € 12,000,000 (EUR) |
| Organisation | European Commission H2020 |
| Sector | Public |
| Country | Belgium |
| Start | 11/2019 |
| End | 04/2023 |
| Description | FSID Project Grant |
| Amount | £50,000 (GBP) |
| Organisation | The Lullaby Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2010 |
| End | 01/2011 |
| Description | Jannsen Investigator Initiated |
| Amount | £680,000 (GBP) |
| Organisation | Johnson & Johnson |
| Department | Janssen Pharmaceuticals |
| Sector | Private |
| Country | United States |
| Start | 01/2013 |
| End | 12/2017 |
| Description | King's College Development Trust Studentship |
| Amount | £63,000 (GBP) |
| Organisation | King's College London |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2006 |
| End | 01/2009 |
| Description | MRC Immunopsychiatry consortium |
| Amount | £200,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2014 |
| End | 09/2016 |
| Description | MRC Research Grant (Eurostress) |
| Amount | £66,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2009 |
| End | 01/2012 |
| Description | Marie Curie |
| Amount | £180,000 (GBP) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 04/2013 |
| End | 03/2015 |
| Description | NARSAD Young and Intermediate Investigator Awards |
| Amount | £310,000 (GBP) |
| Organisation | Autism Speaks |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 01/2006 |
| End | 01/2011 |
| Description | NIHR Senior Investigator |
| Amount | £45,000 (GBP) |
| Funding ID | NF-SI-0616-10074 |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2017 |
| End | 03/2020 |
| Description | Persistent Fatigue Induced by Interferon-alpha: A New Immunological Model for Chronic Fatigue Syndrome |
| Amount | £373,075 (GBP) |
| Funding ID | MR/J002739/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2012 |
| End | 08/2016 |
| Description | Post-doctorate fellowship to Martin Egeland to study inflammation and neurogenesis in rodents |
| Amount | £182,000 (GBP) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 05/2013 |
| End | 04/2015 |
| Description | Professor, Carmine M. Pariante |
| Amount | £100,000 (GBP) |
| Funding ID | NIHR201376 |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2020 |
| End | 03/2025 |
| Description | Scaling-up Health-Arts Programmes: Implementation and Effectiveness Research (SHAPER) |
| Amount | £1,999,998 (GBP) |
| Funding ID | 219425/Z/19/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2019 |
| End | 09/2022 |
| Description | South London and Maudsley NHS Foundation Trust & Institute of Psychiatry NIHR Biomedical Research Centre for Mental Health |
| Amount | £250,000 (GBP) |
| Organisation | South London and Maudsley (SLAM) NHS Foundation Trust |
| Department | NIHR Maudsley Biomedical Research Centre |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2007 |
| End | 01/2012 |
| Description | The Impact of Early Adversity on Trajectories of Brain Maturation and Mental Health in Young Adolescents |
| Amount | £100,144 (GBP) |
| Funding ID | MR/S003444/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 09/2022 |
| Description | To investigate inflammation-related cellular models of depression |
| Amount | £680,000 (GBP) |
| Organisation | Johnson & Johnson |
| Department | Janssen Pharmaceutica |
| Sector | Private |
| Country | Global |
| Start | 11/2013 |
| End | 12/2016 |
| Description | Understanding the role of gender, inflammation and sex hormones in the prevention and treatment of affective disorders Psychiatry Research Trust |
| Amount | £83,444 (GBP) |
| Funding ID | Psychiatry Research Trust |
| Organisation | King's College London |
| Department | Psychiatry Research Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 09/2021 |
| Description | Understanding, predicting, and treating depression in pregnancy to improve mothers and offspring mental health outcomes Research Funder |
| Amount | € 11,293,266 (EUR) |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2022 |
| End | 10/2026 |
| Description | WHAT ARE THE IMMUNE SYSTEM RISK FACTORS FOR DEVELOPING CHRONIC POST-VIRAL FATIGUE FOLLOWING SARS-COV |
| Amount | £99,998 (GBP) |
| Funding ID | KENN192010 |
| Organisation | The Kennedy Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2020 |
| End | 11/2021 |
| Description | Wellcome Project grant |
| Amount | £447,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2009 |
| End | 01/2013 |
| Description | Wellcome Trust Neuroimmunology Consortium |
| Amount | £1,100,000 (GBP) |
| Organisation | Wellcome Trust |
| Department | Wellcome Trust Institutional Strategic Support Fund |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2015 |
| End | 12/2019 |
| Description | Covid research network |
| Organisation | Guy's and St Thomas' NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | We are leading a consortium of scientists interested in the molecular mechanisms underpinning the effects of COVID on the brain |
| Collaborator Contribution | We have led our first submitted publication and our first grant submission |
| Impact | 1) For submission to Molecular Psychiatry Neurogenesis is disrupted in human hippocampal progenitor cells upon exposure to serum samples from hospitalized COVID-19 patients with neurological symptoms Alessandra Borsini, PhD1*, Blair Merrick, MD2, Jonathan Edgeworth, PhD, MD3, Deepak Srivastava, PhD4,5, Anthony C. Vernon, PhD4,5, Gaia Nebbia, PhD, MD3, Sandrine Thuret, PhD4, Carmine M. Pariante, PhD, MD1 1 Stress, Psychiatry and Immunology Laboratory, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, King's College London, UK 2 Centre for Clinical Infection and Diagnostics Research, Guy's and St Thomas' NHS Foundation Trust, London, UK 3 School of Immunology and Microbial Sciences, Guy's and St Thomas' NHS Foundation Trust, London, UK 4 Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK 5MRC Centre for Neurodevelopmental Disorders, King's College London, UK 2) King's Together: Round 10 - Support for re-starting research and research careers post-COVID (NOT FUNDED): Gaining mechanistic insight "in vitro" on how hippocampal brain cells function isare disrupted upon exposure to serum from long-COVID-19 patients with neurological manifestations (neuro long-COVID-19) Role in project Name Faculty Department Position Joint Principal Investigator Carmine M. Pariante (F) Psychiatry, Psychology and Neuroscience Psychological Medicine Academic (Professor) Joint Principal Investigator Alessandra Borsini Psychiatry, Psychology and Neuroscience Psychological Medicine PDRA Joint Principal Investigator Tom Pollak Psychiatry, Psychology and Neuroscience Psychosis Studies Academic (Lecturer) Joint Principal Investigator Leonie Taams Life Sciences & Medicine Immunology, Infection & Inflammatory Disease Academic (Professor) Joint Principal Investigator Clare Brant Arts & Humanities English Language & Literature Academic (Professor) Joint Principal Investigator Anna Reading Arts & Humanities Culture, Media & Creative Industries Academic (Professor) CoI Sandrine Thuret Neuroscience Basic and Clinical Neuroscience Academic (Reader) CoI Tony Vernon Neuroscience Basic and Clinical Neuroscience Academic (Senior Lecturer) CoI Deepak Srivastava Neuroscience Basic and Clinical Neuroscience Academic (Reader) CoI Tim Nicolson Psychiatry, Psychology and Neuroscience Psychosis Studies Academic (Lecturer) CoI Ester Coutinho Neuroscience Clinical and Basic Neurosciences Research Fellow CoI Francesca Capon Life Sciences & Medicine Medical & Molecular Genetics Academic (Reader) CoI Beatrice Pembroke KCL Culture Team Not applicable Executive Director CoI Johanna Kieniewicz KCL Culture Team Not applicable Head of Education and Research Collaborations 3) - Rosetrees Trust - Borsini (PI) 01/02/2021-31/01/2022 £25,000 Effects of COVID-19 on the brain and gaining mechanistic insight "in vitro" - 1 hour/week |
| Start Year | 2021 |
| Description | Department of Psychiatry and Mind-Body Interface Research Centre, China Medical University Hospital, Taichung, Taiwan |
| Organisation | China Medical University Hospital |
| Department | Department of Psychiatry and Mind-Body Interface Research Centre |
| Country | Taiwan, Province of China |
| Sector | Hospitals |
| PI Contribution | Exchange visit between Dr. Su (Taiwan) and Dr. Pariante |
| Collaborator Contribution | Research collaboration with Dr. Su |
| Impact | Many publications have arisen from this collaboration, built on work conducted both in London and in Taiwan: PMID: 18370571; 17888811; 17591516; 17503999; 17070845; 17017838; 20034614. |
| Start Year | 2006 |
| Description | Department of Psychiatry, Newcastle University, UK |
| Organisation | Newcastle University |
| Department | Academic Psychiatry and Regional Affective Disorders Service |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | A study was conducted on EEG and cortisol in the collaborator's laboratory; the study was funded by this grant and was in the original research proposal. |
| Collaborator Contribution | Collaboration with Dr. H. McAllister-Williams for a clinical study on EEG. |
| Impact | The study has been completed and a publication is currently in preparation. |
| Start Year | 2008 |
| Description | EU EARLYCAUSE |
| Organisation | University of Barcelona |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Karim Lekadir, PhD, is the Director of the Artificial Intelligence in Medicine Lab at the Universitat de Barcelona, and is the coordinator for the EU consortium EarlyCause H2020 project. I am the workpackage leader for the celular component, but the overal consortium aims to study the causative mechanisms linking early-life-stress to psycho-cardio-metabolic multi-morbidity |
| Collaborator Contribution | Dr Kadir has led the application phase and contonue to succesfully lead the programme |
| Impact | EU EARLYSTART 06/12/2019-05/12/2023 £391,175 research grant to KCL, Euro6M to the whole consortium |
| Start Year | 2018 |
| Description | EU IMI EU-PEARL |
| Organisation | Vall d'Hebron University Hospital |
| Country | Spain |
| Sector | Hospitals |
| PI Contribution | I am WP leader for depression for a IMI application led by Vall d'Hebron University Hospital. The overal IMI application is dedicated to set up a European platform for clinical trials. |
| Collaborator Contribution | Vall d'Hebron University Hospital has offered scientific and management leadership both during the application phase and now during the grant |
| Impact | - EU IMI EU-PEARL 01/10/2019-30/09/2024 £514,145 to KCL (Euro 12M to the consortium) |
| Start Year | 2018 |
| Description | Erasmus University, Rotterdam |
| Organisation | Erasmus University Rotterdam |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Exchange of researchers and data |
| Collaborator Contribution | Training in laboratory expertise and exchange of data |
| Impact | Papers and new grant applications. |
| Start Year | 2008 |
| Description | Immuno-NeuroPsychiatry Thematic Working Group |
| Organisation | European College of Neuropsychopharmacology (ECNP) |
| Country | Netherlands |
| Sector | Charity/Non Profit |
| PI Contribution | The TWG on "Immuno-NeuroPsychiatry" comprise internationally recognized clinical centers particularly helpful for the development of data bases, pathophysiological and therapeutic studies in humans. They will be completed by the implementation of research groups using laboratory animal models to perform high-level translational research projects, enabling to substantially improve mechanistic and functional knowledge about the exact nature of the relationships of inflammatory state with relevant clinical dimensions, treatment resistance and therefore promote appropriate pharmacological interventions. I am a senior member of this initiative, andmany members of my research group also are part of this. |
| Collaborator Contribution | ECNP has led the process bringing the many scientist together and offered infrastructure support for the relevant publications, including dissemination and press support. |
| Impact | De Picker LJ, Dias MC, Benros ME, Vai B, Branchi I, Benedetti F, Borsini A, Leza JC, Kärkkäinen H, Männikkö M, Pariante CM, Güngör ES, Szczegielniak A, Tamouza R, van der Markt A, Fusar-Poli P, Beezhold J, Leboyer M. Severe mental illness and European COVID-19 vaccination strategies. Lancet Psychiatry. 2021 Feb 17:S2215-0366(21)00046-8. doi: 10.1016/S2215-0366(21)00046-8. Epub ahead of print. Erratum in: Lancet Psychiatry. 2021 Feb 25;: PMID: 33609450; PMCID: PMC7906735. De Picker LJ, Yolken R, Benedetti F, Borsini A, Branchi I, Fusar-Poli P, Carlos Leza J, Pariante C, Pollak T, Tamouza R, Vai B, Vernon AC, Benros ME, Leboyer M; ECNP Immuno-NeuroPsychiatry TWG. Viewpoint | European COVID-19 exit strategy for people with severe mental disorders: Too little, but not yet too late. Brain Behav Immun. 2021 Jan 23:S0889-1591(21)00012-X. doi: 10.1016/j.bbi.2021.01.008. Epub ahead of print. PMID: 33493625. Branchi I, Poggini S, Capuron L, Benedetti F, Poletti S, Tamouza R, Drexhage HA, Penninx BWJH, Pariante CM; European College of Neuropsychopharmacology (ECNP) ImmunoNeuroPsychiatry Thematic Working Group and Marion Leboyer. Brain- immune crosstalk in the treatment of major depressive disorder. Eur Neuropsychopharmacol. 2020 Dec 29:S0924-977X(20)30968-8. doi: 10.1016/j.euroneuro.2020.11.016. Epub ahead of print. PMID: 33386229. |
| Start Year | 2019 |
| Description | MRC Immunopsychiatry Consortium |
| Organisation | GlaxoSmithKline (GSK) |
| Department | Psychiatry (GSK) |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Design of studies, execution of studies and experiments |
| Collaborator Contribution | Funding of studies, contribution to research strategy and design |
| Impact | Data exchange, publications (in preparation) |
| Start Year | 2014 |
| Description | MRC Immunopsychiatry Consortium |
| Organisation | Medical Research Council (MRC) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Design of studies, execution of studies and experiments |
| Collaborator Contribution | Funding of studies, contribution to research strategy and design |
| Impact | Data exchange, publications (in preparation) |
| Start Year | 2014 |
| Description | MRC Social Genetic and Developmental Psychiatry Centre (SDGP |
| Organisation | King's College London |
| Department | MRC Social Genetic and Developmental Psychiatry Centre (SDGP) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration with Dr. Aitchison and Professors Moffitt and Caspi. |
| Collaborator Contribution | Development of a parallel clinical and pre-clinical research strategy linked with the current proposal. |
| Impact | PMID 19751968, 19074533, 18458677, 19996051, 18391129, 17229839, 20157309 |
| Start Year | 2006 |
| Description | Pharmaceutical Science Research Division, Kings College London (KCL), UK |
| Organisation | King's College London |
| Department | School of Medicine KCL |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The experiments on blood-brain barrier permeability have been conducted in the collaborator's laboratory but funded by this grant. |
| Collaborator Contribution | Collaboration with Dr. Sarah Thomas in joint supervision of a PhD student and conducting animal studies. |
| Impact | PMID: 18556350, 17356567, 20881247 |
| Description | Queen's Medical Research Institute, University of Edinburgh, UK |
| Organisation | University of Edinburgh |
| Department | Queen's Medical Research Institute Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I have been in Edinburgh several times to plan the experiments with the collaborators. The collaborators have funded and conducted the study |
| Collaborator Contribution | Collaboration with Professor Seckl in an animal study |
| Impact | PMID: 17356567 |
| Start Year | 2006 |
| Description | Royal College of Surgeons in Ireland |
| Organisation | Royal College of Surgeons in Ireland |
| Department | Department of Psychiatry |
| Country | Ireland |
| Sector | Academic/University |
| PI Contribution | Scientific collaboration on in vitro models relevant to the present project |
| Collaborator Contribution | Collaboration on in vitro models based on present grant |
| Impact | PMID: 18562437, 17938637 |
| Description | SHAPER |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I am co-leading a research programme on art and mental health together with Daisy Fancourt (at UCL) |
| Collaborator Contribution | Dr. Fancourt is co-leading with me and is offering both scientific and managerial leadership |
| Impact | - Wellcome Trust SHAPER 01/10/2019-30/09/2022 £1,999,998 To Scale-up Health-Arts Programmes: Implementation and Effectiveness Research |
| Start Year | 2019 |
| Description | University of Bristol |
| Organisation | University of Bristol |
| Department | School of Clinical Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have planned together animal and human research funded by this grant. |
| Collaborator Contribution | Scientific collaboration with Professor Stafford Lightman |
| Impact | PMID 19336786, 18675469, 17356567, 17016711, 20558006 |
| Description | Wellcome Trust Neuroimmunology Consortium |
| Organisation | H. Lundbeck A/S |
| Department | Neuroscience; Lundbeck |
| Country | Denmark |
| Sector | Private |
| PI Contribution | A research consortium; we recruit and select patients and deliver research |
| Collaborator Contribution | They participate to the research strategy |
| Impact | Data collection, publications (all still in preparation), novel potential targets for antidepressants discovery |
| Start Year | 2014 |
| Description | Wellcome Trust Neuroimmunology Consortium |
| Organisation | Johnson & Johnson |
| Country | United States |
| Sector | Private |
| PI Contribution | A research consortium; we recruit and select patients and deliver research |
| Collaborator Contribution | They participate to the research strategy |
| Impact | Data collection, publications (all still in preparation), novel potential targets for antidepressants discovery |
| Start Year | 2014 |
| Description | Wellcome Trust Neuroimmunology Consortium |
| Organisation | Pfizer Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | A research consortium; we recruit and select patients and deliver research |
| Collaborator Contribution | They participate to the research strategy |
| Impact | Data collection, publications (all still in preparation), novel potential targets for antidepressants discovery |
| Start Year | 2014 |
| Description | Wellcome Trust Neuroimmunology Consortium |
| Organisation | Wellcome Trust |
| Department | Wellcome Trust Strategic Award |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | A research consortium; we recruit and select patients and deliver research |
| Collaborator Contribution | They participate to the research strategy |
| Impact | Data collection, publications (all still in preparation), novel potential targets for antidepressants discovery |
| Start Year | 2014 |
| Title | Clinical Trial with Minocycline in depressed patients with high-inflammation |
| Description | The trial has been completed and publiished as Nettis MA, Lombardo G, Hastings C, Zajkowska Z, Mariani N, Nikkheslat N, Worrell C, Enache D, McLaughlin A, Kose M, Sforzini L, Bogdanova A, Cleare A, Young AH, Pariante CM, Mondelli V. Augmentation therapy with minocycline in treatment-resistant depression patients with low-grade peripheral inflammation: results from a double-blind randomised clinical trial. Neuropsychopharmacology. 2021 Jan 28. doi: 10.1038/s41386-020-00948-6. Epub ahead of print. PMID: 33504955. This study aimed to investigate the role of baseline levels of peripheral inflammation when testing the efficacy of antidepressant augmentation with minocycline in patients with treatment-resistant depression. We conducted a 4-week, placebo-controlled, randomised clinical trial of minocycline (200 mg/day) added to antidepressant treatment in 39 patients selected for elevated levels of serum C-reactive protein (CRP = 1 mg/L), n = 18 randomised to minocycline (M) and n = 21 to placebo (P). The main outcome was the change in Hamilton Depression Rating Scale (HAM-D-17) score from baseline to week 4, expressed both as mean and as full or partial response, in the overall sample and after further stratification for baseline CRP=3 mg/L. Secondary outcomes included changes in other clinical and inflammatory measures. Changes in HAM-D-17 scores and the proportion of partial responders did not differ between study arms. After stratification for CRP levels <3 mg/L (CRP-) or =3 mg/L (CRP+), CRP+/M patients showed the largest changes in HAM-D-17 scores (mean ± SD = 12.00 ± 6.45) compared with CRP-/M (2.42 ± 3.20, p < 0.001), CRP+/P (3.50 ± 4.34, p = 0.003) and CRP-/P (2.11 ± 3.26, p = 0.006) patients, and the largest proportion (83.3%, p = 0.04) of partial treatment response at week 4. The threshold point for baseline CRP to distinguish responders from non-responders to minocycline was 2.8 mg/L. Responders to minocycline had higher baseline IL-6 concentrations than non-responders (p = 0.03); IFN? was significantly reduced after treatment with minocycline compared with placebo (p = 0.03). Our data show some evidence of efficacy of add-on treatment with minocycline in MDD patients but only in those with low-grade inflammation defined as CRP =3 mg/L. |
| Type | Therapeutic Intervention - Drug |
| Current Stage Of Development | Early clinical assessment |
| Year Development Stage Completed | 2021 |
| Development Status | Closed |
| Clinical Trial? | Yes |
| Impact | This is the first trial selecting depressed patients based on a blood-test, hence the first attempt to bring personalised medicine into psychiatry. The paper has just been published and so impact is ongoing. |
| URL | https://pubmed.ncbi.nlm.nih.gov/33504955/ |
| Description | A follow-up interview after one year of pandemic, for the Science Weekly Guardian Podcast |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Ian Sample is joined again by Prof Carmine Pariante to discuss pandemic burnout and how to look after our mental health over the coming months |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.theguardian.com/science/audio/2021/mar/02/covid-19-why-are-we-feeling-burnt-out |
| Description | Antidepressants may not be perfect, but they DO save lives: Expert reveals how life-changing the drug can be when used in the right way |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Professor Carmine Pariante has treated thousands of patients with depression Despite expert claims the pills have devastating side-effects, he stands by them They work when used correctly, especially alongside psychological therapy Read more: http://www.dailymail.co.uk/health/article-4243156/Antidepressants-not-perfect-save-lives.html#ixzz4awYvDP2Q |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.dailymail.co.uk/health/article-4243156/Antidepressants-not-perfect-save-lives.html |
| Description | Article for The Independent |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | An opinion piece defending the safe use of antidepressants. As a psychiatrist, I know that Johann Hari is wrong to cast doubt on antidepressants Suggesting that prescribing antidepressants to a patient who suffers from clinical depression is the equivalent of treating them as a 'machine with malfunctioning parts' is wrong, unhelpful and even dangerous Carmine Pariante Wednesday 10 January 2018 14:00 GMT |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.independent.co.uk/voices/johann-hari-depression-anti-depressants-psychiatrists-pills-ther... |
| Description | BBC Radio 4 - Phantoms in the Brain, an interview on inflammation and mental health |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | BBC Radio 4 - Phantoms in the Brain, an interview on inflammation and mental health - |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://tr.ee/aobhoiaxi6 |
| Description | Blog on the Huffington Post |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A regular blog entry that I have on the Huffington Post on topics of mental health |
| Year(s) Of Engagement Activity | 2012,2015,2016,2017 |
| URL | http://www.huffingtonpost.co.uk/author/carmine-pariante |
| Description | CNN Interview on COVID |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Carmine Pariante, talks live on CNN with Victor Blackwell on "re-entry syndrome" after COVID. Broadcasted on18 June 2021, the interview discusses the anxiety that people might feel after the lockdown, when we are invited to go back of our offices and to socialise with our friends. And what can we all do about it - both as employers and employees. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.youtube.com/watch?v=1HgXqHCXZe4 |
| Description | Immune reactions to severe Covid may trigger brain problems, study finds |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview to the Guardian related to one of my papers, Neurogenesis is disrupted in human hippocampal progenitor cells upon exposure to serum samples from hospitalized COVID-19 patients with neurological symptoms, https://www.nature.com/articles/s41380-022-01741-1 |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.theguardian.com/world/2022/oct/05/immune-reactions-to-severe-covid-may-trigger-brain-pro... |
| Description | Inspire the Mind - a new online publication on mental health |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | InSPIre the Mind is new online publication directed by Carmine Pariante. It will bring the point of view of a group of clinicians and researchers working in mental health. In this new publication, we want to complement people's accounts by discussing the clinical and the scientific evidence underpinning these personal experiences, while also sharing with the readers our research, our clinical work, and or our cultural and societal considerations. We are the members of the Stress, Psychiatry and Immunology (SPI) Lab at the Institute of Psychiatry, Psychology and Neuroscience, at King' College London, and these are our stories. So far, the website has been visited more than 100,000 times |
| Year(s) Of Engagement Activity | 2019,2020,2021 |
| URL | http://www.inspirethemind.org |
| Description | Interview for BBC Radio 4 Programme |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | BBC health reporter James Gallagher explores the increasing body of evidence that a dysfunctional immune system is responsible for the depression or psychotic illness experienced by hundreds of thousands, perhaps millions, of people in the UK. James talks to the psychiatrists investigating this new understanding of mental illness and to people who may benefit from treatments aimed at the immune systems rather than their brain cells. "I believe this is one of the strongest discoveries in psychiatry in the last twenty years", says Professor Carmine Pariante of his and other research on the immune system and depression. "It allows us to understand depression no longer as just a disorder of the mind and not even a disorder of the brain, but a disorder of the whole body. It shifts conceptually what we understand about depression." James also talks to New York journalist Susannah Cahalan. She began to experience paranoid delusions and florid hallucinations when her immune system made damaging antibodies against part of the molecular circuitry in her brain. Treatment to eliminate the antibodies prevented her committal to psychiatric hospital. Psychiatrist Professor Belinda Lennox at the University of Oxford says she has evidence that a significant proportion of people presenting for the first time with psychotic symptoms are victims of a similar autoimmune problem. Producer: Rachael Buchanan and Andrew Luck-Baker. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.bbc.co.uk/programmes/b07pj2pw |
| Description | Interview for The Guardian Science Weekly Podcast on the Impact of the pandemic on mental health |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | As the lockdown in the UK looks set to continue, Ian Sample speaks to Prof Carmine Pariante about the physiological and psychological effects of social isolation. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.theguardian.com/science/audio/2020/apr/15/covid-19-how-can-social-isolation-affect-us-po... |
| Description | Interview on the Daily Mail on my research on CFS/ME |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Journalist Jo MacFarlane interviewed me on my research on CFS/ME and its relevance to Long Covid |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.dailymail.co.uk/health/article-8303305/Will-Covid-19-survivors-face-lifetime-illness-lik... |
| Description | Interview with New York Times on my research on CFS/ME |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Journalist Moises Velasquez-Manoff interviewed me on my research on CFS/ME and its relevance to long-covid |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.nytimes.com/2021/01/21/magazine/covid-aftereffects.html |
| Description | Interview with Vice.com on my research on CFS/ME |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Journalist Nichola Kelly interviewed me on my research on CFS/ME and its relevance to Long Covid |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.vice.com/en/article/z3evby/young-people-with-coronavirus-symptoms-relapse |
| Description | Laboratory Facebook account |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | This is the Facebook page of the Stress, Psychiatry and Immunology Laboratory; The Stress, Psychiatry and Immunology Laboratory (SPI Lab) is an academic research laboratory within King's College London, led by Professor Carmine Pariante. Our team is made up of clinicians, research and postgraduate students who work across a range of clinical settings. Some of the disorders we investigate include depression, first-episode psychosis, women in the perinatal period (and their infants), individuals with history of trauma, and patients with inflammation-related medical disorders such as viral hepatitis and chronic fatigue. We place a strong emphasis on biological and molecular research relevant to mental health, using biological samples derived from patient populations, experimental cellular and animal models. |
| Year(s) Of Engagement Activity | 2015,2016,2017,2018,2019,2020,2021 |
| URL | https://www.facebook.com/SPILabKCL/ |
| Description | Live radio interviews on BBC Woman's Hour |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | For my paper on fish oil in children with ADHD, I was interviewed on BBC radio for Woman's Hour |
| Year(s) Of Engagement Activity | 2017,2019 |
| URL | https://www.bbc.co.uk/programmes/p07y5vdb |
| Description | Marking #WorldMentalHealthDay with a European Patients' Podcast |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | European Patients' Podcast: The Voice of Patients in Europe By eupatientsforum The European Patients' Podcast is your source for conversation and news around the world of patient advocacy and empowerment. This podcast is brought to you by the European Patients' Forum, the leading voice of patient organisations in Europe with 77 members across the continent. Marking #WorldMentalHealthDay with a European Patients' Podcast |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://anchor.fm/eupatients/episodes/Marking-WorldMentalHealthDay-with-the-EU-PEARL-project-e1ossck... |
| Description | Personal twitter account |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | This is my personal twitter account: Carmine M. Pariante @ParianteSPILab - Psychiatrist and researcher @SPILabKCL. Writer & Editor @inspirethemind_ @BrainBehavImm @BBI_Health. President @ISPNE. Creativity. Social justice. And kung fu. |
| Year(s) Of Engagement Activity | 2015,2016,2017,2018,2019,2020,2021 |
| URL | https://twitter.com/ParianteSPILab |
| Description | Plenary Lecture at the Conference of Forensic Psychiatry of the Royal College of Psychiatrists |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | A plenary lecture on my research on depression and inflammation |
| Year(s) Of Engagement Activity | 2017 |
| Description | Plenary Lecture at the Italian Society for Psychopathology |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A plenary lecture on my research on depression and the immune system |
| Year(s) Of Engagement Activity | 2017 |
| Description | Salon London public event on stress and mental health |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | More than 100 people attended this public event as part of Salon London, an established series of cultural events in London. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.salon-london.com/event/the-science-of-stress |
| Description | Visit of HRH The Duchess of Cambridge to Professor Pariante's laboratory |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The Duchess of Cambridge visits King's College London's IoPPN and the Mother and Baby Unit at Bethlem Royal Hospital The Duchess of Cambridge visited Professor Pariante's laboratory at the Maurice Wohl Clinical Neuroscience Institute at King's College London to find out more about the Institute of Psychiatry, Psychology & Neuroscience's (IoPPN) pioneering 'bench to bedside' mental health research and to meet leading scientists in the area. The Duchess continued to the Mother and Baby Unit, Royal Bethlem Hospital, South London and Maudsley NHS Foundation Trust, to meet clinicians and patients. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.kcl.ac.uk/ioppn/news/records/2018/january/duchess-of-cambridge-visits-kings-college-lond... |