UK-Brazil Joint Centre for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology (CADDE)

Lead Research Organisation: University of Oxford
Department Name: Biology

Abstract

Recently, Brazil has been affected by unexpected and explosive epidemics of insect-transmitted viruses (arboviruses), most notably Zika, chikungunya, dengue, and yellow fever viruses. The huge economic burden of the Zika epidemic in Brazil and the widespread presence of urban mosquitos in the country highlight an urgent need for accurate predictions of disease spread, particularly in large, densely populated regions. Our UK-Brazil Partnership (CADDE) will enhance and expand an excellent existing collaborations, with the aim of anticipating and controlling future epidemics of arboviruses in Brazil. It is our vision for CADDE to become a strategic centre of excellence for research in South America that focuses on providing timely analysis, based on genomic, epidemiological and geographic evidence, to anticipate and control transmission of arboviruses, today and in the future..

Our research questions include: 1) What arboviruses circulate in human, mosquito and reservoir populations in Brazil? 2) Where and how do arboviruses persist during non-epidemic periods? 3) What are the biological and medical implications of the genetic diversity of circulating arboviruses and of mutations in their genomes? 4) What factors control the transformation of a single introduction of a new arbovirus into human populations into sizeable epidemic, and 5) how quickly can we detect and characterise such epidemics, and how best to respond? Active virus surveillance in vectors and reservoirs will be combined with seroprevalence surveys in blood donors (to characterise features such as virus genomics, transmission, and immunity). Novel portable genome sequencing technologies and modern real-time epidemiological analyses will be applied to the most important arboviruses in Brazil.

Using modern techniques that can unify the information from genomics and epidemiology, CADDE will strengthen the evidence base for public health actions, and strengthen the capacity of Brazilian health system to respond to emerging arboviral diseases. We will transform local capacity by training research scientists and public health personnel in field epidemiology, laboratory testing, the use of portable genomic technologies, and computational and statistical methods.

Technical Summary

1. What is the genetic diversity of Brazilian arboviruses?
We will develop rapid cost-effective sequencing protocols (specific & untargeted) for Brazilian arboviruses and apply them to human, vector & animal samples from 5 established cohorts. We will test hypotheses of associations between arbovirus genetic diversity and key phenotypes, e.g. (1) Are there viral mutations linked to Zika-associated microcephaly cases? (2) What is the epidemiological impact of ZIKV sexual transmission? (3) Are there viral genomic signatures of sylvatic vs urban YFV transmission cycles? (4) Are there genomic signatures associated with disease severity or vector specificity for Brazilian arboviruses?
2. Why do arbovirus epidemics spread & persist?
To better understand local arbovirus transmission in São Paulo and how this relates to wider virus spread , we will investigate factors driving the spread and persistence of transmission in vector, human and non-human primate populations. We will determine when and where is transmission risk for arbovirus infection is highest, and whether risk zones vary under different scenarios.
3. Can we quantify mobility and anticipate transmission?
Prevention and control measures are hindered by poor understanding of how human, vector and reservoir species mobility contributes to arbovirus spatial spread. Through geospatial modelling we will identify hotspots of transmission in São Paulo and Brazil, with the aim of anticipating arbovirus dissemination. We will develop a platform for real-time arbovirus detection and epidemiological analysis.
4. How do we develop a precision public health model for Brazil?
We propose that precise public health inventions are possible through the integration of data from multiple data sources. Specifically we will combine primary surveillance data with rapid analysis systems to track and predict disease distributions. Crucially we will develop Brazilian technical expertise and capacity to act upon this information.

Planned Impact

The Brazil-UK Centre for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology (CADDE) will enhance the ability of the Brazilian health system to prepare for and to respond to future outbreaks of arboviruses. We will improve the integration of cutting-edge genomic, bioinformatics and epidemiological approaches within existing public health systems in Brazil. We will develop and apply new techniques to collect and integrate genomic and epidemiological data in order to better understand viral transmission. Basing public health policy and response on scientific data analysis will allow response to new outbreaks to be deployed more rapidly and more efficiently by local and national public health bodies across São Paulo and Brazil.

We will share the data that we generate within Brazil in an open-access manner with international public health agencies, including WHO and PAHO. The early identification of newly emerging arboviral pathogens in humans via metagenomic protocols will allow rapid development of standardized assays for high-throughput surveillance that can be adopted cross-continentally by WHO and PAHO. Additionally, CADDE will improve the global understanding of the epidemiology of emerging and existing arboviral pathogens. We will quantify risk-factors for arboviral transmission hotspots that can be translated to international scales, and also provide estimates of the prevalence of asymptomatic infections. This knowledge is will help guide the WHO and PAHO to make effective policy to protect public health, including the evaluation of vaccination targets.

We will improve the capacity of laboratories in Brazil to generate and access genomic and epidemiological data through a detailed training programme and development of simple platforms to display epidemiological data in real-time. By developing simple, free-to-use platforms that automatically display real-time analyses of collated epidemiological data to local public health personnel, we will maximise the use of scientific data in public health response. We will provide training in basic epidemiological and computation analyses to public health personnel in São Paulo, empowering them to perform additional analyses and allow a flexible and localised response to new outbreaks. We will introduce public health laboratories in Brazil to novel, portable genomic technologies, allowing local laboratories to generate critically important sequence data within 24 hours of sample collection. The widespread adoption of rapid sequencing technologies across Brazil will allow hypotheses about the transmission of arboviruses to be tested in real-time with genomic data, and enable genomic data to directly guide the design of local public health interventions.

The wider scientific community will benefit from the data generated by CADDE. All data, methods and results that will be generated during this project will be made available in an open-access manner, allowing the highest possible impact of our work. Techniques that are developed through CADDE will drive further research into integrated epidemiological and genomic analyses that can be deployed in real-time to help control viral transmission.

The general public in São Paulo and across Brazil will benefit from improved public healthcare as a result of the use of new technologies to improve outbreak responsiveness. We hope that the general public will gain a better understanding of arboviral transmission and modern sequencing technologies through the provision of regular media interviews by members of the CADDE team about our ongoing work, and opportunities to discuss directly with scientists at dedicated public engagement events.
 
Title Aedes aegypti illustration by designer Paulo Presti 
Description Artwork for CADDE website 
Type Of Art Artwork 
Year Produced 2019 
Impact The illustration has attracted considerable attention to our website and helped to increase awareness of mosquito surveillance and taxonomy in Brazil. 
URL https://www.caddecentre.org/arbovirology/
 
Description Our work to date has dramatically improved the availability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), yellow fever virus (YFV), zika virus (ZIKV), dengue virus (DENV) and chikungunya virus (CHIKV) genome sequences in Brazil. We are using these genomes to generate new epidemiological findings about viral evolution and spread (CADDE Deliverable 9). In total, we have developed new sequencing protocols that we used to generate over 3000 new viral genomes. Data and protocols are important public resources for pandemic preparedness and development of possible treatment and preventive medicines. Data has been shared with the scientific community on our project website (https://www.caddecentre.org/genomics/) and dedicated repositories such as GitHub, Dryad, GISAID, International Nucleotide Sequence Database Collaboration (INSDC), which includes NCBI Genbank. We have developed new sequencing protocols that sequence up to 8 arboviruses simultaneously using the same protocol (Deliverable 1). Importantly, we have also fully developed a new metaviromic portable sequencing approach (Deliverable 3 and 4), and published these protocols freely on our website so others could further validate and use for virus discovery (Deliverable 14).

Working closely with the Brazilian Ministry of Health and the reference laboratory Instituto Adolfo Lutz in São Paulo, we sequenced the first SARS-CoV-2 virus genomes from Brazil (also the first in Latin America) in only 48 hours. When combined with the patient travel information, our data showed that the two first cases in Brazil were the result of separate introductions to the country rather than the localized spread in Brazil. SARS-CoV-2 has brought a new research direction for our project. Since we first detected circulation of this virus in February 2020, we have contributed to the SARS-CoV-2 epidemic response with >44 studies on the evolution and epidemic spread of SARS-CoV-2 in Brazil and Latin America, including early assessments of risk of transmission across the country, generation of the first large representative dataset of SARS-CoV-2, and the earliest detection and characterization of a novel variant of concern (VOC), the P.1/Gamma VOC, in Manaus. We found that P.1/Gamma emerged in mid-November 2020 and was 1.7 to 2.4 more transmissible compared to previous non-P.1 infections. Our studies further showed that >75% of the population in Manaus had been exposed to SARS-CoV-2 until October 2020 and provided conclusive evidence that unmitigated epidemics result in devastating levels of mortality. Our findings were shared rapidly with local and global teams, including the World Health Organization (WHO) and Pan American Health Organization (PAHO).

In December 2019, we led a practical workshop on genomic sequencing and analysis for approximately 30 participants from across the globe, and trained 7 people from laboratories at the Brazilian Ministry of Health. Several of these researchers used learned genomic techniques to sequence the first cases of SARS-CoV-2 in their own countries. Through these activities, we established 6 new research collaborations within Brazil, Ecuador, Panama, Angola and the UK.

We mapped to unprecedented detail the ecological niche for sylvatic yellow fever transmission in Brazil, identified the mode and tempo of the virus' recent introduction in Sao Paulo state. More recently, we identified the key ecological and epidemiological drivers of yellow fever virus transmission in Brazil, with implications for vaccination campaigns and public health efforts to curb this viral threat.

We have also investigated the clinical impact of multiple arboviruses, including CHIKV and ZIKV. Specifically, we have recently shown that the dominant CHIKV lineage (ECSA) circulating in Brazil can cause death in individuals from both risk and non-risk groups, including young adults. We have also sequenced 7 new genomes of ZIKV from infants with microcephaly (only 3 where available at the beginning of the project), and have identified that there are no shared viral variants that could specifically explain the occurrence of microcephaly (https://cadde.herokuapp.com/ZIKV).

The novel data, insights and rapid protocols for untargeted virus sequencing provide new avenues for global pandemic preparedness toolkits. For example, the new sequencing methods can be deployed to discover and flexibly sequence many different virus genomes from clinical cases with unknown etiology. We have used this protocol to investigate the virome of two fatal hemorrhagic cases who tested negative for YFV. Using our new protocols, we identified two deadly infections caused by the Sabiá virus, a New World arenavirus for which only 3 naturally occurring cases had been known to date. This finding has led us to question what proportion of cases and deaths are not diagnosed due to the lack of suitable rapid diagnostic tools and capacity. Going forward, we will focus on virus-agnostic genomic strategies to detect viral outbreaks in wildlife, vector and human populations. Only armed with such information can we prevent the next pandemic.
Exploitation Route CADDE has strengthened the scientific evidence base for public health in Brazil, enhanced the capacity of the Brazilian research and health systems, and has improved the preparation for, and response to, current and future outbreaks of emerging and re-emerging viruses. Our discovery of P.1/Gamma VOC and of the hidden deadly hemorrhagic fever infections in Sao Paulo that were previously attributed to yellow fever, as well as the rapid development of new tools to identify its transmission are prime examples of the project's commitment to provide key information for public health response in real-time. CADDE has also revolutionized data sharing in Brazil during pandemics, with methods and thousands of viral genomes shared via findable, accessible, interoperable and reusable (FAIR) principles. CADDE has strengthened collaborative links between public health researchers, clinical virologists and world leaders in genomics, virus evolution and genomic epidemiology. Moreover, the project has developed epidemiological, mathematical, spatial and genomic approaches to quantify arboviral transmission and inform disease control at fine spatial scales. Knowledge and expertise will continue to be transferred through capacity-building and technology-transfer initiatives, with the aim of improving the preparedness of the Brazilian health system to future arboviral disease outbreaks. This will be relevant for any pathogen threat. As an example of CADDE's flexibility, our project generated the first genome and corresponding phylogenetic analysis of the first COVID-19 in South America in a record time of 48 hours and provided significant contributions towards mapping SARS-CoV-2 in Brazil (detailed elsewhere). CADDE will also continue to build on our existing communication corridors with policymakers, such as the WHO. CADDE's legacy will continue in the name of Prof Ester Sabino, an award created in her name for Women Scientists of the State of São Paulo, in partnership with the Academy of Sciences of the State of São Paulo Paulo (ACIESP), and Prof Faria is a member of the GLAD-HP Alliance and the new Technical Advisory Group on Arbovirus (TAG-Arbovirus) from the World Health Organisation (23 November 2021). 'The PIs will continue to serve in their personal capacities to represent the broad range of disciplines relevant to emerging and re-emerging viruses). CADDE collaborated extensively with WHO, PAHO, UKSHA, CoG-UK (Co-PIs of CADDE, Profs. Nick Loman and Oliver Pybus), Brazil and UK Government, and the local Ministries of Health to communicate our findings and maximize their societal impact.
Sectors Communities and Social Services/Policy,Education,Environment,Healthcare,Leisure Activities, including Sports, Recreation and Tourism,Government, Democracy and Justice,Culture, Heritage, Museums and Collections,Pharmaceuticals and Medical Biotechnology
URL https://www.caddecentre.org/
 
Description Our findings had a broad impact both on health policy and on wider society and we have adapted to researching the SARS-CoV-2 epidemic. We initiate strong links with the WHO, PAHO, UKHSA and the Brazilian and UK Ministry of Health that are allowing project findings to directly impact governmental and regional health policies nationally, and internationally. All of our research findings to date have been directly communicated with the local and national public health institutes and stakeholders, including the finding that arenavirus had caused cases of haemorrhagic fever in Brazil and more recently the discovery of a novel SARS-CoV-2 variant of concern. Jornal da Cultura noted that Brazil stands out in the production of research and scientific articles during the pandemic, and was responsible for almost three percent of all world production, ahead of countries like Holland, Switzerland and Japan. The University of São Paulo is among the twenty institutions that are the most published in the world. The leading PI of CADDE, Prof Nuno Faria, remains a member of WHO's Global Laboratory Alliance for the Detection of High-Threat Pathogens (GLAD-HP) and together with Prof. Ester Sabino they participate in weekly update meetings on SARS-CoV-2. Prof Nuno Faria was a member of the drafting group to create a WHO implementation guide that was developed in consultation with experts with experience in the various fields of genome sequencing. He facilitates knowledge transfer from the WHO directly to PAHO, the Brazilian Ministry of Health and CADDE team members. Prof Faria is also in communication via WhatsApp with the Secretary of Health Surveillance at the Brazilian Ministry of Health and is helping to provide consultancy during the current outbreak. The acting British Ambassador to Brazil tweeted this year, '...United Kingdom is doing dedicated work to identify and monitor variants of the #COVID19. Part of this task is the result of a very relevant exchange of knowledge with Brazil, with the brilliant scientists of the @CaddeProject'. CADDE outputs have directly impacted preparedness by the Brazillian Government, who recommended a reassessment of flexibility in Amazonas in order to reverse the upward trend of SARS-CoV-2 cases. Findings have also had an impact internationally, as the UK Government issued a travel ban to the UK from the following countries: South America, Cape Verde and Portugal, due to early data sharing of our research on the variant of concern, SARS-CoV-2 P.1/Gamma VOC in Manaus, Amazonas. In addition to the impact within Brazil, we have helped improve preparedness and genomic sequencing capacity in other laboratories across South America and more widely. CADDE directly trained >100 participants in virus sequencing technologies. Several participants are now using the techniques to sequence arboviruses and emerging viruses such as SARS-CoV-2 in their own states and countries, including in Ministry of Health laboratories. We continue to support their activities, through openly sharing expertise and shipping limited specific reagents (e.g., primers for sequencing of SARS-CoV-2 and other reagents) to Ministry of Health laboratories including those in Panama, Mexico, Angola and Portugal. We have actively engaged with the media to share our findings and activities with a wide audience. To date, our outputs have been featured in >5000 articles globally, including New York Times, Globo, BBC (UK and Brazil), and Washington Post reaching an international audience. We have given many TV interviews including Globo and Sky news, and podcasts with BBC Science in Action. The Director of the National Institute of Health, Dr Frances S. Collins highlighted CADDE research in his blog ' Tracking the evolution of a variant of concern'. A collaborative effort of the UK-Brazil CADDE Project further included the creation of an online web app to monitor the development of the COVID-19 epidemic in Brazil in real time at a local level - the CLIC-Brazil app. Members of the CADDE group have been honoured by various awards, including acceptance into the Turing Enrichment Scheme at the Alan Turing Institute, Personalities of the Year (British Chamber, 2020), Brazilians of the year (ISTOÉ, 2020), and captured by the famous Brazilian cartoonist Mauricio Sousa. PI Ester Sabino and Postdoctoral researcher Jaqueline Goes de Jesus have been highlighted in Forbes Brasil as the top 20 Successful Women of 2020, and 2021 respectively. Dr Goes was honored with a Barbie doll as chosen by Mattel, for leading the sequencing of the first SARS-CoV-2 genomes from Latin America. Prof. Ester Sabino was awarded the Armando de Salles Oliveria medal from USP and hosts an award in her own name, the Ester Sabino award which recognises the invaluable contribution of female scientists to the scientific, technological and economic development of the State of São Paulo. Dr Jaqueline Goes awarded with Zilda Arms Commenda (CNS Resolution - to grace personalities who have offered relevant contributions to the defense of the universal right to health and to the Unique Health System in Brazil). DPhil candidate, Darlan Candido, won the Applied Bioinformatics & Public Health Microbiology prize, awarded by Wellcome Connecting Science for his short talk 'Genomic surveillance of a novel SARS-CoV-2 variant of concern in Manaus, Brazil', part of CADDE's research portfolio. The CADDE Project has been featured in several case studies: the Newton Fund wrote a case study on CADDE and the fast and effective response to COVID-19 (September 2021). The Medical Research Council is currently also writing a case study for our project entitled "CADDE Project - genomic surveillance in the time of COVID-19"; the UKRI wrote of CADDE's global contribution towards SARS CoV-2 in an editorial 'Tracking COVID-19 in Brazil' and in Revista Piaui highlighted our successful teamwork strategy in a 3-page report named "The story of CADDE's research mapping Sars-Cov-2'- De Pelotas a Boa Vista". Many of these awards feature the key role of the women (including women of colour) thereby driving the agenda of supporting women in STEM to a wider audience, and more broadly inclusivity and diversity in our collaboration in the research performed. We hope that this will inspire an increasingly diverse segment of society to enter careers in science or engage with scientific findings. We hold weekly meetings with an international group of collaborators from over 10 countries, and our publication collaborators span over 12 countries. We have produced over 50 publications to date, including invited commentaries in the Lancet and Nature Medicine. Several of our publications reached very high Altmetric scores (>1000), with our publication in The Lancet reaching an Altmetric score of 8421. One of our publications has been cited in three WHO Policy documents and by the Inter-American Development Bank. Our two posts in Virological.org are the 5th and 8th most viewed of all time, attracting over 83.8K views (First cases of coronavirus disease (COVID-19) in Brazil, South America) and 135K (Genomic characterisation of an emergent SARS-CoV-2 lineage in Manaus: preliminary findings) views respectively, and have been reported in numerous news outlets. Our outreach has also grown on a large scale; our website has had 43,268 page views, 13,370 new users, with 23,679 sessions with users from 155 countries. Our Twitter account, @CADDEProject, has over 4000 followers and there have been over 3 million tweet impressions and over 25K profile visits.
First Year Of Impact 2019
Sector Communities and Social Services/Policy,Education,Environment,Healthcare,Leisure Activities, including Sports, Recreation and Tourism,Government, Democracy and Justice,Culture, Heritage, Museums and Collections
Impact Types Cultural,Societal,Economic,Policy & public services
 
Description CADDE Posters approved for presentation at Brazilian National Congress
Geographic Reach National 
Policy Influence Type Contribution to a national consultation/review
URL https://www.cbv2021.com.br/e-p%C3%B4ster
 
Description CADDE Website and Twitter
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact The CADDE website (https://www.caddecentre.org/) reached 3849 new users in its first 3 months (Google Analytics). We had a total of 4,504 sessions and 7,617 page views. Most of its audience is Brazilian (77%) and we are currently translating the website to Portuguese and Spanish so we can further increase CADDE's visibility throughout Latin America. Regarding our Twitter Account, @CaddeProject has already 865 followers (as of 12 March 2020). Since the beginning of the @CaddeProject account, we have had 253,481 Tweet Impressions (number of times a tweet shows up in a person's timeline). Both the website and the Twitter analytics attest to the significant impact that CADDE is having in the scientific community by influencing research and improving knowledge in the field of emergent infectious diseases. Our outreach has grown on a large scale; our website has had 30,800 page views, 13,370 new users, with 17,315 sessions with users from 148 countries. Our twitter account, @CADDEProject, has over 3400 followers; from 12/20-02/21 there have been over 1.3 million tweet impressions and over 21K profile visits.
URL https://www.caddecentre.org/
 
Description CADDE presented to UK Embassy in Brazil
Geographic Reach Multiple continents/international 
Policy Influence Type Contribution to a national consultation/review
Impact Nuno Faria presented CADDE Projects to the UK Embassy in Brazil/SBMT.
 
Description CADDE presented to WHO
Geographic Reach Multiple continents/international 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
Impact Ester Sabino and Lewis Buss present CADDE serological survey updates to the World Health Organisation on 27/11/2020.
 
Description Citation in SAGE document (NERVTAG) 27 Jan 2021
Geographic Reach National 
Policy Influence Type Citation in other policy documents
Impact There is currently insufficient evidence to assess whether variant P.1 is associated with any change in disease severity, but the information provided in this document has been used to guide policy and decision-making for international leaders.
URL https://www.bbc.co.uk/news/uk-politics-55655388
 
Description Citation in WHO Policy Document - COVID-19 variants
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
URL https://www.who.int/publications/m/item/weekly-epidemiological-update-on-covid-19---23-march-2021
 
Description Consultancy to SVS Ministry of Health on COVID19 Surveillance
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
Impact Upon the first detection of COVID19 in Brazil (26 Feb 2020), PI Nuno Faria provided upon request information to the SVS Ministry of Health in how to proceed. One major limitation of rapid and equitable access to diagnostic was the lack of positive control for COVID laboratory screening. Following our suggestions, SVS requested a local laboratory to amplify the virus which was then inactivated and distributed across the network of public health laboratories in Brazil.
 
Description Engagement with FCDO Science Envoy
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Epidemiological and clinical characteristics of the COVID-19 epidemic in Brazil has been included in COVID Reference's Top 10
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact On the 2nd August 2020 the CADDE Publication 'Epidemiological and clinical characteristics of the COVID-19 epidemic in Brazil' was included in COVID Reference Top 10. CADDE Principal Investigator, Dr Nuno Rodrigues Faria, Dr Julio Croda and colleagues present and contextualise Brazilian COVID-19 cases for March, April and May 2020.
URL https://covidreference.com/top-10-august-2
 
Description Fiocruz recommends reassessment of flexibility in Amazonas
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
Impact Publication directly impacted preparedness by the Brazilian government. Fiocruz recommended reassessment of flexibility in Amazonas: '(Fiocruz) recommends reinforcing measures to prevent Covid-19 in Manaus and the state of Amazonas, in order to reverse the upward trend in cases of severe acute respiratory syndrome. since Epidemiological Week 34 (16 to 22 August)'
URL https://agenciabrasil.ebc.com.br/saude/noticia/2020-09/fiocruz-recomenda-reavaliacao-da-flexibilizac...
 
Description First CADDE workshop on Genomic Epidemiology
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact The CADDE Genomic Epidemiology Workshop (2 to 6 December 2019) was a training hands-on course based on integrating Oxford Nanopore MinION sequencing with genetic data analysis for outbreak investigation. Researchers were trained in library preparation, running the MinION sequencer, and analyzing sequencing data using bioinformatics and phylogenetic tools. Using novel protocols developed by the CADDE project, researchers generated dengue virus genomes in only a few hours. The workshop trained 16 researchers across different regions in Brazil and 18 other researchers from 16 different countries, including from 7 Ministry of Health laboratories: Brazil, Puerto Rico, Panama, Mexico, Colombia, Angola, and Portugal. Three months after our workshop, 6 of these laboratories are using methods learnt during our CADDE workshop to sequence SARS-CoV-2 genomes cases from the new outbreak that will be key to monitor the efficacy of current diagnostic tools, design vaccines and track the international spread of the virus.
URL https://www.caddecentre.org/programme-for-the-cadde-genomic-epidemiology-workshop/
 
Description Global Laboratories Alliance for the Diagnosis of High Threat Pathogens
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a guidance/advisory committee
Impact World Health Organization (WHO) headquarters coordinate the Global Laboratories Alliance for the Diagnosis of High Threat Pathogens (GLAD HP). CADDE PI Prof Faria has been invited to the GLAD HP alliance as an expert in genetic analyses and data sharing in November 2019. As a result of his involvement in GLAD HP, CADDE has been able to capitalize on rapid knowledge and international capacity from weekly GLAD HP TC calls sharing important information concerning laboratory testing and the dynamics of COVID-19.
 
Description Leading International Guidelines for COVID19 sequencing (WHO) (ongoing)
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a guidance/advisory committee
 
Description Publication 'Evolution and epidemic spread of SARS-CoV-2 in Brazil' - Citation in three WHO Policy Documents, and by The Inter-American Development Bank.
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
URL https://science.altmetric.com/details/86328003/policy-documents
 
Description Study highlighted as an example of 'international collaboration and focus in science'
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Tweet from the UK Ambassador on our work highlighting our study (Evolution and epidemic spread of SARS-CoV-2 in Brazil) as an example of "international collaboration and focus in science to draw the path we need to follow to move forwards [as a society]".
URL https://twitter.com/VijayR_HMG/status/1286688712752009220?s=20
 
Description UK Academy of Sciences
Geographic Reach South America 
Policy Influence Type Participation in a guidance/advisory committee
 
Description A translational study for the identification, characterisation and validation of severity biomarkers in arbovirus infections
Amount R$ 4,000,000 (BRL)
Organisation São Paulo Research Foundation (FAPESP) 
Sector Public
Country Brazil
Start 12/2017 
End 12/2021
 
Description An actionable framework for surveillance of mosquito-borne viral diseases in Mexico - QMUL Global Challenge Research Fund, Large Grant Scheme 2019-20
Amount £20,000 (GBP)
Organisation Queen Mary University of London 
Sector Academic/University
Country United Kingdom
Start 12/2020 
End 12/2021
 
Title CMMID COVID-19 Repository and Interactive App 
Description Epiforcasts is a tool to identify estimates of changes in the reproduction number, rate of spread and doubling time during the COVID-19 epidemic in Brazil, providing national estimates for municipality level analyses. The tool can report state level Rt plots to report varying epidemic trajectories across Brazil and a possible strategy for targeted genotyping of samples. 
Type Of Material Improvements to research infrastructure 
Year Produced 2021 
Provided To Others? Yes  
Impact The tool has been used by several Governors and Public Health decision makers across Brazil to monitor SARS-CoV-2 on local scales. 
URL https://epiforecasts.io/covid/posts/national/brazil/
 
Title COVID-19 Local Information Comparison (CLIC Brazil) 
Description The COVID-19 Local Information Comparison (CLIC Brazil) web application allows local public health decision makers and researchers to compare the current COVID-19 epidemic in different local areas (municipalities) across Brazil. It aims to: 1) Identify hotspots of COVID-19 disease, 2) Compare the outbreak trajectories between municipalities to understand where the epidemic is growing fastest, 3) Assess the socioeconomic drivers of COVID-19 risk. Was/is useful for local decision makers in planning and evaluating their response to the pandemic and how it compares to other areas in real time. 
Type Of Material Improvements to research infrastructure 
Year Produced 2021 
Provided To Others? Yes  
Impact Publication: how online web apps can be used to give real time insights into disease spread with the example of COVID-19 in Brazil: 'Tracking the emergence of disparities in the subnational spread of COVID-19 in Brazil using an online application for real-time data visualisation: a longitudinal analysis' https://www.sciencedirect.com/science/article/pii/S2667193X21001150 (The Lancet Regional Health - Americas). 
URL https://cmmid.github.io/visualisations/lacpt
 
Title Code and data to reproduce analysis of the preprint: [Genomics and epidemiology of a novel SARS-CoV-2 lineage in Manaus, Brazil] 
Description Code and data to reproduce analysis of the preprint: [Genomics and epidemiology of a novel SARS-CoV-2 lineage in Manaus, Brazil] 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2021 
Provided To Others? Yes  
Impact The code for a novel multi-strain epidemiological model was added to our GitHub repository on 28 Feb 2021, and will allow others to model the epidemiology of SARS-CoV-2 variants of concern. 
URL https://github.com/CADDE-CENTRE/Novel-SARS-CoV-2-P1-Lineage-in-Brazil
 
Title Metagenomics protocol for laboratory diagnostic 
Description We report a Smart-Seq (Switch Mechanism at the 5' End of RNA Templates) protocol using random 9-n priming. The protocol is compatible with the Oxford Nanopore Technologies RLB rapid, barcoded adapters available from the SQK-RPB004 kit. This protocol has been developed and tested by the CADDE team and has been used to successfully identify Sabia virus infections in yellow fever suspected cases. 
Type Of Material Technology assay or reagent 
Year Produced 2020 
Provided To Others? Yes  
Impact The method was able to successfully identify a virus that hadn't been detected since 1990 (see our Publication List). Our results suggested that several yellow fever suspected cases that tested negative by PCR may have been caused by Sabia virus, an arenavirus that causes hemorrhagic fever. 
URL https://www.caddecentre.org/protocols/
 
Title PCR protocol to detect SARS-CoV-2 VOC in Brazil 
Description The recently emerged variants of concern (VOC) B.1.1.7 in UK, B.1.1.35 in South Africa and P.1 in Brazil have increased transmissibility and are rapidly spreading worldwide. These variants have several substitutions that allow them to bypass the immune responses and are up to 10 times more contagious than the previous circulating SARS-COV-2 lineages. While in some regions P.1 predominates (as several estates in Brazil), in other countries B.1.1.7 or B.1.1.35 are most prevalent. Therefore, real-time surveillance of VOC is the key for rapid public health responses. In this matter, RT-PCR protocols that are capable of detecting VOCs easily and rapidly are needed. We developed and validated a protocol that detect simultaneously the 3 most widespread VOC. Although this protocol does not discriminate among the VOCs, it can reliably detect mixed infection. Importantly, our protocol successfully identified a co-infection by two SARS-COV-2 lineages (P.1 and B.1), confirmed through complete genome sequencing. 
Type Of Material Technology assay or reagent 
Year Produced 2021 
Provided To Others? Yes  
Impact The protocol has already been used to identify mixed infections and is now been implemented across the largest diagnostic laboratory in Brazil. 
URL https://www.protocols.io/view/real-time-pcr-protocol-to-screen-for-sars-cov-2-va-bszbnf2n
 
Title Real-time genetic analysis of arboviruses in Brazil 
Description We designed a CADDE auspice-nextstrain platform to have real-time visualizations of yellow fever, chikungunya, dengue, and oropouche virus phylogenies and correspondent diversity along virus genomes. 
Type Of Material Improvements to research infrastructure 
Year Produced 2020 
Provided To Others? Yes  
Impact The tool has been used by the Secretary of Health in Sao Paulo, with the Ministry of Health and the Pan American Health Organization to detect spread into new regions and changes in arbovirus genomes. 
URL https://www.caddecentre.org/genomics/
 
Title Code and the data necessary to run the model and associated Bayesian analysis to estimate SARS-CoV-2 HFR 
Description his repository contains the code and the data necessary to run the model and associated Bayesian analysis via Stan in A Brizzi, C Whittaker, LMS Servo et al. "Factors driving extensive spatial and temporal fluctuations in COVID-19 fatality rates in Brazilian hospitals". Imperial College London (06-10-2021), doi https://doi.org/10.25561/91875. 
Type Of Material Computer model/algorithm 
Year Produced 2022 
Provided To Others? Yes  
Impact This research dataset contains curated hospital admission data, Brazilian registry death data, hospital resource data obtained from the National Register of Health Facilities (processed and redistributed under CC BY-4.0), vaccination data, genomic data, population projections and data on daily burials from Manaus. . 
URL https://github.com/CADDE-CENTRE/covid19_brazil_hfr
 
Title Data and covariates from "Human movement and environmental barriers shape the emergence of dengue" 
Description Contains municipality level dengue data for Mexico and Brazil and a range of environmental and mobility covariates summarised at the admin2 level for use in the linked paper. Further details on each covariate available in the full paper. 
Type Of Material Database/Collection of data 
Year Produced 2023 
Provided To Others? Yes  
URL https://figshare.com/articles/dataset/Data_and_covariates_from_Human_movement_and_environmental_barr...
 
Title Data and covariates from "Human movement and environmental barriers shape the emergence of dengue" 
Description Contains municipality level dengue data for Mexico and Brazil and a range of environmental and mobility covariates summarised at the admin2 level for use in the linked paper. Further details on each covariate available in the full paper. 
Type Of Material Database/Collection of data 
Year Produced 2023 
Provided To Others? Yes  
URL https://figshare.com/articles/dataset/Data_and_covariates_from_Human_movement_and_environmental_barr...
 
Title Dataset to estimate SARS-CoV-2 seroprevalence in 8 cities in Brazil 
Description We provide 4 datasets needed to reproduce the analyses: https://datadryad.org/stash/dataset/doi:10.5061/dryad.dz08kps08. We also provide a dataset containing convalescent plasma donors used to estimate sensitivity; a dataset containing tested samples collected before the beginning of the SARS-CoV-2 pandemic in Brazil; a dataset containing repeat blood donors used to estimate the seroreversion probability curve. 
Type Of Material Database/Collection of data 
Year Produced 2022 
Provided To Others? Yes  
Impact This dataset shed light on the attack rates and infection fatality ratio across age-groups in 8 cities in Brazil. 
URL https://github.com/CADDE-CENTRE/seroprevalence_eight_cities
 
Title Datasets of genome sequences from arboviruses 
Description Our research database includes updated visualizations of genomic data generated by CADDE and other groups for improved epidemiological understanding and outbreak response in Brazil. 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
Impact The database has been used by Pan American Health Organization and the Brazilian Ministry of Health. Five publications are currently being prepared to describe in detail the >800 genome sequences (>500 yellow fever virus, 200 dengue, 100 chikungunya ) generated over the first year of the project. 
URL https://www.caddecentre.org/genomics/
 
Title Dengue Sao Paulo database 
Description The database is composed of dengue notified cases that were extracted from the Health Surveillance System database. Notification of every suspect dengue case is mandatory, and dengue surveillance is considered a priority in the epidemiological surveillance system in Brazil. About 50% of cases were reported within 3 days after the first symptoms, and 90% of cases were digitized within 7 days of notification. A suspect dengue case is defined as any person presenting with acute fever and at least two of the following symptoms: nausea, vomiting, rash, myalgia, headache, retro-orbital pain, petechiae, positive loop test or leukopenia. The database encompasses information on age, gender, home address, clinical symptoms, specific laboratory investigation, probable site of dengue infection, name of health facility notifying the case (assumed to also be the location of treatment), disease severity and outcome. After notification from health professionals, the epidemiological surveillance department collects information and inputs the data into the digital database. At the central level, the database is post-processed: duplicate records are deleted, and medical and laboratory records are requested when needed for completeness of data. 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? No  
Impact To the best of our knowledge, the database is the largest of its kind in the Americas. It will inform decision making in dengue control in Sao Paulo and Brazil. 
 
Title Downloadable datasets as part of the CLIC Brazil online web app 
Description Includes age-standardised COVID-19 incidence rates around other variables all at a municipality level in Brazil. 
Type Of Material Database/Collection of data 
Year Produced 2021 
Provided To Others? Yes  
Impact Ongoing 
URL https://cmmid.github.io/visualisations/lacpt
 
Title Field Survey Entomological Zones 
Description the largest concentration of fragments and continuous areas of the Atlantic forest in São Paulo State follows the coastline. Aiming to find genetically and statistically significant sampling zones for YFV, we conducted surveys in three forest areas, two of which are more than 150 km to north and south of the São Paulo city and a forested area adjacent to the metropolitan zone: A) Survey zone in São Paulo State (SPS) south coast - presenting the largest remaining area of preserved and original Atlantic Forest in Brazil. Several locations are being sampled in this area, especially in the cities: Itapitangui, Cananéia, and Pariquera-Açu; B) Survey zone in Cantareira Mountain Range in the north of São Paulo City (SPC) - areas with large amounts of parks, vegetated fragments and forest reserves very adjacent to the metropolitan zone of SPC. This zone covers sampling locations of different cities, notably: Caieiras, Diadema, São Paulo, Mairiporã; C) Survey zone in SPS north coast - presenting important Atlantic Forest coastline reserves with several quilombo settlements (high human presence integrated with forests), with primary and secondary forests. This sampling zone covers several localities surrounding Ubatuba city: Enseada, Itaguá, Perequê-Açu, and Barra Seca. 
Type Of Material Data handling & control 
Year Produced 2020 
Provided To Others? No  
Impact Data is currently being generated and as such, no impact has been achieved so far. 
 
Title Metadata record for: Dataset on SARS-CoV-2 non-pharmaceutical interventions in Brazilian municipalities 
Description This dataset contains key characteristics about the data described in the Data Descriptor Dataset on SARS-CoV-2 non-pharmaceutical interventions in Brazilian municipalities. Contents: 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format 
Type Of Material Database/Collection of data 
Year Produced 2021 
Provided To Others? Yes  
Impact This database offers an opportunity for researchers and policymakers to examine the potential impacts of NPIs on COVID-19 transmission and control in Brazil. 
URL https://springernature.figshare.com/articles/dataset/Metadata_record_for_Dataset_on_SARS-CoV-2_non-p...
 
Title Mobility data (local, national and international) from Manaus 
Description Number of passengers moving from Manaus to other cities, states (Brazil), and countries. 
Type Of Material Database/Collection of data 
Year Produced 2021 
Provided To Others? Yes  
Impact This data has been used to track P.1 spread over the world. See e.g. https://cov-lineages.org/global_report_P.1.html 
URL https://www.medrxiv.org/content/10.1101/2021.02.26.21252554v1
 
Title Monkeypox genome data 
Description Raw sequence genome data from earliest case in Brazil. 
Type Of Material Database/Collection of data 
Year Produced 2022 
Provided To Others? Yes  
Impact The publication of raw sequence data from the first mpox case in Brazil aimed to encourage researchers to make data available to the community. 
URL https://github.com/CADDE-CENTRE/Monkeypox
 
Title Mosquito species database from Sao Paulo 
Description Our current mosquto database comprises the geographical extension of the entire State of São Paulo and adjacent areas from neighboring brazilian states. The current database has a total of 16266 records of specimens from the Culicidae family, and this amount is composed of records of 31 different genus and 239 different species. The database was collated from five different sources: (1) SpeciesLink biodiversity database, contributing with 6456 records, (2) Global Biodiversity Information Facility - GBIF adding more 224 records; (3) The global compendium of Aedes aegypti and Ae. albopictus occurrence from Kraemer and collaborators (2015), providing 2551 records, (4) 7035 records from São Paulo State Superintendence for Control of Endemic Diseases - SUCEN from collaborators Juliana Nogueira, Rosa Maria Tubaki, Gerson Laurindo Barbosa, Luis Filipe Mucci and Antonio Henrique Alves Gomes. 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? No  
Impact The complete database was finalized in February 2020 and is currently being analyzed. 
 
Title Phylodynamic Subsampling 
Description This code and data were used for the analysis presented in "Using multiple sampling strategies to estimate SARS-CoV-2 epidemiological parameters from genomic sequencing data" - https://www.medrxiv.org/content/10.1101/2022.02.04.22270165v1 
Type Of Material Data analysis technique 
Year Produced 2022 
Provided To Others? Yes  
Impact We found that analysis using unsampled datasets result in the most biased estimates of epidemiological parameters. Sampling strategy choices may be an influential yet neglected component of sequencing analysis pipelines. 
URL https://github.com/rhysinward/Phylodynamic-Subsampling
 
Title SARS-CoV-2 Genomic data from Brazil 
Description We generated and shared >850 SARS-CoV-2 genomes from Brazil in GISAID, including 184 genomes for the P.1 variant of concern. 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
Impact This data represents the largest dataset compiled by a single lab in Brazil and has been used extensively utilized by other researchers. 
URL https://www.gisaid.org/
 
Title Serosurvey data for Manaus and Sao Paulo 
Description Openly sharing in real-time monthly curated serosurvey data from blood donors through the Brazil-UK Centre for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology (CADDE) Centre GitHub website. 
Type Of Material Database/Collection of data 
Year Produced 2021 
Provided To Others? Yes  
Impact Other research teams are now designing new models to account to accurately estimate attack rates while accounting for waning of immunity in Manaus. 
URL https://github.com/CADDE-CENTRE/Manaus_Blood_Donors_Seroprevalence
 
Title Yellow fever human database (2014-2019) 
Description This is the largest yellow fever database of human cases available from the Americas. From 2016-2019 alone it contains 1959 confirmed cases in humans with detailed information. This data was obtained through our collaborator in FUNED Minas Gerais, Ministry of Health. 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? No  
Impact The data was received in early March 2020. A publication and a Scientific Data paper will be prepared to share this data as soon as possible. 
 
Description CADDE Collaboration with INIS Angola 
Organisation Ministry of Health
Country Angola 
Sector Public 
PI Contribution We have trained several members of the Angola Ministry of Health laboratory in the detection and sequencing of mosquito-borne viruses such as dengue and yellow fever, viruses also circulating in Brazil.
Collaborator Contribution Transfer of knowledge and information about ongoing circulation of mosquito-borne viruses.
Impact Genomic sequencing and epidemiological analysis. Outcome was a publication: https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0010255
Start Year 2020
 
Description Federal University of Rio de Janeiro 
Organisation Federal University of Rio de Janeiro
Country Brazil 
Sector Academic/University 
PI Contribution Our CADDE project has provided expertise and intellectual input in several genomic and phylodynamic projects from Renato Aguiar's team members. Given the role of human mobility in arbovirus spread, the partnership with the Federal University of Rio de Janeiro (Prof Renato Aguiar) will bring critical insight as it allow us to put our findings from Sao Paulo into a larger geographic context.
Collaborator Contribution Prof. Renato Aguiar (Federal University of Rio de Janeiro) has provided access to unique data - 7 genomes of Zika microcephaly samples (from 2015 to 2020 only 4 genomes have been made available). This data is directly relevant to test the association between Zika virus mutations and microcephaly status, the main goal of Deliverable 5. A visualization of the new Zika virus-associated microcephaly genomes being analyzed by the CADDE project together with Prof. Renato Aguiar can be visualized here: https://cadde.herokuapp.com/ZIKV?c=Microcephaly.
Impact This partnership will help to successfully complete Deliverable 5, and will help to put into context any genomic findings from data collected in Sao Paulo.
Start Year 2019
 
Description Instituto Evandro Chagas 
Organisation Evandro Chagas Institute
Country Brazil 
Sector Charity/Non Profit 
PI Contribution Our CADDE project has provided formal expertise in genomic sequencing to the Evandro Chagas Institute (IEC), one of the three reference laboratories in Brazil, through our first genomic epidemiology workshop entitled "CADDE Genomic Epidemiology Workshop" (Program here: https://www.caddecentre.org/programme-for-the-cadde-genomic-epidemiology-workshop/). Two members from IEC participated in the workshop where CADDE provided expertise in genomic sequencing using the latest technologies.
Collaborator Contribution IEC (Prof Marcio Nunes) has contributed with >150 yellow fever genomes from non-human primates and humans that are currently being analyzed to address key deliverables. The collaboration between CADDE and IEC has been very fruitful, and we have now gathered a total of >600 new yellow fever virus genomes from the recent outbreak. The novel genomic data will allow us to quantify arboviral transmission and inform arbovirus disease control (deliverables 7 and 8). A visualization of the yellow fever virus complete genome data that has been generated by the CADDE team can be found here: https://cadde.herokuapp.com/YFV.
Impact The collaboration with IEC reference laboratory has resulted in access to additional yellow fever data from the north of Brazil. This will be critical to the successful completion of key deliverables in our project. The partnership with IEC has the potential opens doors to future important collaborative links in arbovirus research.
Start Year 2019
 
Description Oswaldo Cruz Foundation 
Organisation Oswaldo Cruz Foundation (Fiocruz)
Country Brazil 
Sector Public 
PI Contribution Our CADDE project has provided formal expertise in genomic sequencing to the Oswaldo Cruz Foundation through our first genomic epidemiology workshop entitled "CADDE Genomic Epidemiology Workshop" (Program here: https://www.caddecentre.org/programme-for-the-cadde-genomic-epidemiology-workshop/). Three members from Fiocruz participated in the workshop where CADDE provided expertise in genomic sequencing using the latest technologies.
Collaborator Contribution Oswaldo Cruz Foundation (Prof Ana Bispo) has contributed with 200 yellow fever positive from non-human primates and humans that are currently being analyzed to address key deliverables. The collaboration between CADDE and FioCruz has been very fruitful and we have now gathered >600 new yellow fever virus genomes from the recent outbreak. The novel genomic data will allow us to quantify arboviral transmission and inform arbovirus disease control (deliverables 7 and 8). A visualization of the yellow fever virus complete genome data that has been generated by the CADDE team can be found here: https://cadde.herokuapp.com/YFV.
Impact The collaboration with FioCruz has resulted in knowledge transfer and has helped facilitated the exchange of material between the CADDE team in Sao Paulo and FioCruz in Rio de Janeiro. It has contributed to a better understanding of the yellow fever virus epidemiology during the recent outbreak in the southeast region.
Start Year 2019
 
Description Secretaria de Vigilância em Saúde - Ministério da Saúde 
Organisation Government of Brazil
Country Brazil 
Sector Public 
PI Contribution Our CADDE project has provided formal expertise in genomics to the Ministry of Health team during our CADDE through our first genomic epidemiology workshop entitled "CADDE Genomic Epidemiology Workshop" (Program here: https://www.caddecentre.org/programme-for-the-cadde-genomic-epidemiology-workshop/). One member of the Ministry of Health was invited as a keynote speaker and continued as a participant for the one week course in genomic sequencing using the latest technologies.
Collaborator Contribution The strategic partnership with the Brazilian Ministério da Saúde (Dr. Wanderson de Oliveira and Dr. Julio Croda) (May 2019) started in August 2019 (https://twitter.com/CaddeProject/status/1161711565869072384) and has provided national-level arbovirus data that be important for real-time cartographies of arbovirus transmission (deliverable 10). It will also be key to promote the rapid-response outbreak protocols (deliverable 14). Moreover, this partnership further augments CADDE's collaboration network and is providing important information to guide policy at a national level.
Impact The collaboration with the Brazilian Ministry of Health is of utmost importance for CADDE and will be important to the successful completion of key deliverables in our project. Moreover, the partnership with the Brazilian Ministry of Health (the PIs are in direct contact with head members of SVS through WhatsApp and hold annual meetings in Brasilia) has the potential opens doors to future important collaborative links in the virus outbreak research.
Start Year 2019
 
Description University of Sao Paulo Faculty of Medicine in Ribeirao Preto 
Organisation Universidade de São Paulo
Department Ribeirão Preto School of Medicine
Country Brazil 
Sector Academic/University 
PI Contribution CADDE has provided expertise, intellectual input and training in portable genomic sequencing at the University of Sao Paulo Faculty of Medicine in Ribeirao Preto between December 2019 and January 2020. Because of our contribution, we were able to provide a clinical, demographic and genomic description of the largest chikungunya cohort ever described to date (manuscript is now under review in New England Journal of Medicine).
Collaborator Contribution The new partnership with the University of Sao Paulo Faculty of Medicine in Ribeirao Preto (Prof. Luiz Tadeu Moraes Figueiredo, Chair Professor of the Virology Research Centre) has placed CADDE at the epicenter of arbovirus top research in Sao Paulo state and Brazil. Dr. William Souza from Prof. Figueiredo team has led a small group that involved several CADDE team members in a detailed investigation of the largest cohort of chikungunya fatal cases ever reported. This new collaboration with Dr. de Sousa has brought IMT-USP and Oxford together with teams from Northeast Brazil. Together with the new partnerships, we are now generating additional data that will deliverable new insights into the spread of the chikungunya virus in the northeast region (deliverable 9).
Impact The collaboration with the University of Sao Paulo Faculty of Medicine in Ribeirao Preto has resulted in access to additional chikungunya data. Moreover, Dr. William de Souza's impressive application has been selected among 18 international candidates and Dr. William will start his postdoc in Oxford in April 2020.
Start Year 2019
 
Title PCR Protocol to detect SARS-CoV-2 variants of concern 
Description Real-Time PCR protocol to screen for SARS-COV-2 variants of concern (B.1.1.7, P.1 and B.1.1.35) 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Initial development
Year Development Stage Completed 2021
Development Status Under active development/distribution
Impact Our protocol has successfully identified co-infection by two SARS-COV-2 lineages and is currently being implemented in the largest laboratory in Brazil. 
URL https://www.protocols.io/view/real-time-pcr-protocol-to-screen-for-sars-cov-2-va-bszbnf2n
 
Title CLIC Brazil online web app 
Description We created an online app called COVID-19 Local Information Comparison, or CLIC-Brazil (https://cmmid.github.io/visualisations/lacpt). This provides real-time visualisation of COVID-19 data in Brazil at the municipality level. In the app, case and death data are standardised to allow comparisons to be made between places and over time. Estimates of Rt, a measure of the rate of propagation of the epidemic, over time are also made. 
Type Of Technology Webtool/Application 
Year Produced 2021 
Impact Ongoing 
URL https://cmmid.github.io/visualisations/lacpt
 
Title GRINCH - Tracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/501Y-V2 
Description The software tool grinch (global report investigating novel coronavirus haplotypes) tracks the international spread of lineages of concern with automated daily reports. Further, it is linked to a custom tracking website (cov-lineages.org/global_report.html) which hosts this daily report and will continue to include novel SARS-CoV-2 lineages of concern as they are detected. 
Type Of Technology Webtool/Application 
Year Produced 2022 
Open Source License? Yes  
Impact GRINCH has been used widely across the globe to track SARS-CoV-2 variants of concern. 
URL http://cov-lineages.org/global_report.html
 
Description 'Sequenciamento genético da COVID-19' - CADDE PI Ester Sabino interview with State legislative Press 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact The Legislative Connection Program, carried out virtually by the Alesp Network, welcomes Ester Sabino, Associate Professor at Faculdade de Medicina USP, to speak about the genetic sequencing of COVID-19.
Year(s) Of Engagement Activity 2020
URL https://www.youtube.com/watch?v=ry5_Juzo0JI
 
Description @CADDEProject Twitter 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The @CADDEProject Twitter account has recently had a large increase in followers to over 3300 as of 03/21.
Over the last 3 months there have been over 1.3 million tweet impressions, and over 21K profile visits. The Twitter thread about our new preprint received half a million impressions and over 15,000 engagements in two days after it was published on February 27.
Year(s) Of Engagement Activity 2021
URL https://twitter.com/CaddeProject
 
Description A team of health professionals is trained to work in Genomic Surveillance in the State 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact A Genomic Surveillance area of the State Health Surveillance Center (CEVS) was developed which involved training 15 professionals, coordinated by CADDE Principal Investigator, Dr Ester Sabino due to pioneering sequencing of COVID-19 earlier this year. The group developed projects using the MinION from Oxford Nanopore for genetic sequencing, and were trained by members of the Institute of Tropical Medicine and USP biologists, Pâmela dos Santos Andrade and Thais de Moura Coletti.
Year(s) Of Engagement Activity 2020
URL https://saude.rs.gov.br/equipe-de-profissionais-da-saude-e-treinada-para-atuar-em-vigilancia-genomic...
 
Description American Committee on Arthropod-Borne Viruses ACAV 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Nuno Faria presented CADDE giving invited talk to the American Committee on Arthropod-Borne Viruses (ACAV) 6th November.
Year(s) Of Engagement Activity 2020
URL https://www.astmh.org/annual-meeting/past-meetings
 
Description Applied Bioinformatics & Public Health Microbiology prize winner 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Darlan Da Silva Candido was the recent recipient of the Applied Bioinformatics & Public Health Microbiology prize, awarded by Wellcome Connecting Science.
The prize was awarded to the CADDE PhD student for his short talk at the Applied Bioinformatics & Public Health Microbiology virtual conference, presenting findings on 'Genomic surveillance of a novel SARS-CoV-2 variant of concern in Manaus, Brazil'.
Year(s) Of Engagement Activity 2021
 
Description Article in the New York Times 'Virus Variant in Brazil Infected Many Who Had Already Recovered From Covid-19' 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The New York Times published an article titled 'Virus Variant in Brazil Infected Many Who Had Already Recovered From Covid-19' on 01/03/2021 reporting quotes from Dr Nuno Faria and Dr Ester Sabino, and findings from the manuscript published on 26 February 2021.
Year(s) Of Engagement Activity 2021
URL https://www.nytimes.com/2021/03/01/health/covid-19-coronavirus-brazil-variant.html
 
Description BBC News Brasil: Covid: Variant accelerates youth intubation and SP advises seeking help on the 1st day of symptoms 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact BBC News Brasil referenced the recent CADDE publication in Science, in an article titled 'Covid: Variant accelerates youth intubation and SP advises seeking help on the 1st day of symptoms' on 19 April 2021.
Year(s) Of Engagement Activity 2021
URL https://www.bbc.com/portuguese/brasil-56763719
 
Description BBC News article 'New cases in Brazillian city dash herd immunity hopes 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact BBC News UK wrote an article 'New cases in Brazilian city dash herd immunity hopes', in response to the publication published in medRxiv, 'COVID-19 herd immunity in the Brazilian Amazon'
.
'A scientific study posted on the website medRxiv suggested that Manaus may have reached herd immunity, the point at which enough people have antibodies to the virus that it slows or stops the spread. Scientists estimated that up to 66% of the population there had antibodies to Covid-19.' "All signs indicate that it was the very fact of being so exposed to the virus that brought about the reduction in the number of new cases and deaths in Manaus," the study's co-ordinator was quoted as saying.
Year(s) Of Engagement Activity 2020
URL https://www.bbc.co.uk/news/live/world-54315280/page/4
 
Description BBC Science in Action Podcast 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact BBC Science in Action 'The unchecked spread of Covid-19 in Manaus' podcast released on 11th December 2020.
Year(s) Of Engagement Activity 2020
URL https://www.bbc.co.uk/programmes/w3cszh1f
 
Description Brazil stands out in the production of research and scientific articles during the pandemic. 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Brazil stands out in the production of research and scientific articles during the pandemic. The country was responsible for almost three percent of all world production and was ahead of countries like Holland, Switzerland and Japan. The University of São Paulo is among the twenty institutions that most published in the world.
Year(s) Of Engagement Activity 2020
URL https://www.youtube.com/watch?app=desktop&v=I48d1nCPIyA&fbclid=IwAR19o1mI0Km52x0eCcdHxpLYQDQl4IvQDVX...
 
Description Brazil-UK team played vital role in COVID-19 response 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact News output by Imperial College London 'Recently, the director of the São Paulo Science Foundation (FAPESP) Professor Luiz Mello, and Councillor Head of Academic Section at the Embassy of Brazil in London visited the CADDE team at their new laboratory at Imperial College's White City Campus.'
Year(s) Of Engagement Activity 2022
URL https://www.imperial.ac.uk/news/236274/braziluk-team-played-vital-role-covid19/
 
Description Brazilian and Oxford scientists sequence the new coronavirus detected in Sao Paulo 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact TV Globo is the largest TV channel in Latin America. TV Globo reported the findings from the CADDE project related to preliminary analyses of the sequence of the first case (http://virological.org/t/first-cases-of-coronavirus-disease-covid-19-in-brazil-south-america-2-genomes-3rd-march-2020/409). With CADDE, it took us 2 days to get from sample to sequence, while this takes an average of 15 days in other countries.
Year(s) Of Engagement Activity 2020
URL https://g1.globo.com/bemestar/coronavirus/noticia/2020/02/28/cientistas-do-brasil-e-de-oxford-sequen...
 
Description Brazilian measures are 'insufficient' to contain coronavirus, says international task force of scientists 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact BBC News Brazil article discussed the implications of the CADDE Project study regarding NPIs and virus transmission rate, published in Science: "The study offers evidence that the interventions in force are still insufficient to keep the transmission of the virus under control in the country," says the article, first about the pandemic in Latin America to be published by the magazine Science, this Thursday'
Year(s) Of Engagement Activity 2020
URL https://www.bbc.com/portuguese/brasil-53500667
 
Description Brazilian startup seeks to develop a wholly indigenous COVID-19 diagnostic test 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact CADDE PI Ester Sabino partnered with biotech startup, Biolinker, based in São Paulo, Brazil, who were developing a low-cost high-performance COVID-19 diagnostic test using only locally sourced inputs. The project was selected by FAPESP's innovative Research in Small Business Program (PIPE) in partnership with FINEP, the Brazilian government's innovation agency.

'"Within a few months, we plan to have completed the development of a standardized kit for the detection of IgG circulating antibodies in blood serum produced in a later phase of the disease. The method used is ELISA [enzyme-linked immunosorbent assay]," Mona das Neves Oliveira, principal investigator for the project and founder of the firm, told FAPESP Innovative R&D.'
Year(s) Of Engagement Activity 2020
URL https://pesquisaparainovacao.fapesp.br/brazilian_startup_seeks_to_develop_a_wholly_indigenous_covid1...
 
Description CADDE Project Website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The CADDE Project website shares the group's contributions towards the latest COVID-19 research, publications and news. To date it has reached 30,800 page views, 13,370 new users, with 17,315 sessions with users from 148 countries (03/21).
Year(s) Of Engagement Activity 2021
URL https://www.caddecentre.org
 
Description CADDE Twitter engagement 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact CADDE Twitter has had a large outreach, over a 71 day period it received 2.0M impressions.
Year(s) Of Engagement Activity 2021
URL https://twitter.com/CaddeProject
 
Description CADDE Website and Twitter 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Currently, @CADDEProject twitter has >3640 followers and had >3.1 million tweet impressions, and our website >50k views, 20K users from 158 countries, demonstrating an international reach. @CADDEProject twitter has 3649 followers. Earlier in 2021 there were over 1.3 million tweet impressions, and over 21K profile visits. The Twitter thread on a previous preprint received half a million impressions and over 15,000 engagements in two days after it was published on February 27.
Year(s) Of Engagement Activity 2022
URL https://www.caddecentre.org/
 
Description CADDE has had over 4100 News articles published globally 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact CADDE has had over 4100 news articles published globally in the last year (from 02/20-03/21).
Year(s) Of Engagement Activity 2020,2021
URL https://bv.fapesp.br/en/auxilios/103130/brazil-uk-centre-for-arbovirus-discovery-diagnosis-genomics-...
 
Description CADDE presented at UK COVID-19 Dynamics and Evolution 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Nuno Faria presented CADDE at the UK COVID-19 Dynamics and Evolution, presenting the publication 'Evolution and epidemic spread of the SARS-CoV-2 Epidemic in Brazil'.
Year(s) Of Engagement Activity 2020
URL https://cpd.ucsd.edu/covid19/073020.html
 
Description CADDE project discovers Covid-19 P.1/Gamma variant 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact In a case study titled, 'CADDE project discovers Covid-19 P.1/Gamma variant', the Newton Fund outlined the CADDE Project and it's response to COVID-19; researchers who ensured a fast and effective response which required them to develop an extensive network of collaborators to nationally embed skills and expertise in cutting edge technologies.
Year(s) Of Engagement Activity 2021
URL https://www.newton-gcrf.org/impact/stories-of-change/cadde-project-discovers-covid-19-p-1-gamma-vari...
 
Description COVID-19 pandemic warns of need to monitor new infectious agents, say scientists - Online Seminar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact CADDE PI Ester Sabino participated in an online seminar with Agência FAPESP, highlighting the urgent need for expanding surveillance and monitoring of infectious diseases. Strategies are need to be developed to detect the risk of epidemics before they occur.
Year(s) Of Engagement Activity 2021
URL https://agencia.fapesp.br/pandemia-de-covid-19-alerta-para-necessidade-de-monitorar-novos-agentes-in...
 
Description Comment in The Lancet - Media Outreach 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The Comment published in The Lancet has received a large audience, with over 31 news mentions, 12,436 social media interactions (5434 tweets, 7002 shares, likes and comments on facebook) (as of 04/02/21).
Year(s) Of Engagement Activity 2021
URL https://plu.mx/plum/a/?doi=10.1016/S0140-6736(21)00183-5&theme=plum-jbs-theme&hideUsage=true
 
Description Coronavirus emergency declared 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Interview about the WHO declaration of coronavirus as a public health emergency of international concern.
Year(s) Of Engagement Activity 2020
URL https://www.publico.pt/2020/01/30/ciencia/noticia/coronavirus-oms-declara-emergencia-global-saude-pu...
 
Description DL News: State of SP confirms 25 infected by the Manaus variant 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact P.1 in São Paulo: Statements from an interview from the State Secretary of Health for São Paulo, Jean Gorinchteyn to Good Morning Sao Paulo (from TV Globo) on 15th February:

''Now in the morning, by coincidence, the researcher Ester Sabino [from USP's Institute of Tropical Medicine] informed us that of the three strains that had been placed as British strains, they were resequenced and the possibility of the British strain was ruled out. the statistics increased. We had eight cases in Araraquara for strain P1, which was from Amazonas, and they started to consecrate as 12 strains. Therefore, four more strains of P1 ", said the secretary, during the interview...... A meeting is scheduled for this Monday with researchers and representatives of the Coronavirus Contingency Center to define control measures for the new strain in the state.''
Year(s) Of Engagement Activity 2021
URL https://dlnews.com.br/noticias?id=55574/estado-de-sp-confirma-25-infectados-pela-variante-de-manaus
 
Description Documentary RTP Viruses (2022) 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Prof Nuno Faria provided scientific expertise for three episodes of the Documentary RTP Viruses (2022) (largest TV Portuguese channel)
Year(s) Of Engagement Activity 2022
 
Description Dr Jaqueline Goes de Jesus who led coronavirus sequencing team honoured with Barbie doll 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact On 28 Feb 2020 our team led by Dr Jaqueline Góes de Jesus sequenced the first SARS-CoV-2 genomes from Latin America. Mattel the toy manufacturer chose Brazilian biomedical scientist Jaqueline Góes de Jesus to be honoured with the Barbie doll, for her work in research into the new coronavirus and leading the fight against COVID-19 as part of their 'Thank you Heroes' program. The honour was also given to five other scientists for their contributions in response to SARS-CoV-2.
Year(s) Of Engagement Activity 2021
URL https://www.bbc.com/portuguese/geral-58077745?at_custom3=BBC+Brasil&at_medium=custom7&at_campaign=64...
 
Description Dr Jaqueline Goes representing CADDE at Lemann Foundation - Oxford University 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The Lemann Foundation held a launch event for their new initiative on the 16th November at the Blavatnik School in Oxford to discuss COVID-19, health and education in Brazil.
Dr Jaqueline Goes represented the CADDE Project in a panel discussion alongside Professor Sir Andrew Pollard (Director Oxford Vaccine Group), Dr Beatriz Kira (COVID-19 Government Response Tracker) in conversation with Miguel Lago (Executive Director, IERS - Institute for Health Policy Studies) 'Inside Oxford's COVID-19 projects - reflections on doing real time research in a period of great public need'.
Year(s) Of Engagement Activity 2021
URL https://bsg.ox.ac.uk/events/lemann-foundation-programme-public-sector-launch
 
Description Editorial in Science 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The implications of our paper 'Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic' have been discussed in an editorial in Science.
Year(s) Of Engagement Activity 2021
URL https://science.sciencemag.org/content/371/6526/230
 
Description Editorial in Science 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact CADDE research outputs discussed in the Science Editorial 'New mutations raise specter of 'immune escape'.
Year(s) Of Engagement Activity 2021
URL https://science.sciencemag.org/content/371/6527/329
 
Description Ester Sabino Interview on Flow Podcast 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact CADDE PI Ester Sabino participated in an online podcast called 'Flow' on March 08th 2022. The podcast currently has 122,821 views with an international reach.
Year(s) Of Engagement Activity 2022
URL https://www.youtube.com/watch?v=Q-RSqnutvYU
 
Description Ester Sabino and Jaqueline Goes featured in 'A Cientista Negra' 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact CADDE Principal Investigator Dr Ester Sabino and CADDE Postdoctoral Researcher Dr Jaqueline Goes De Jesus were featured in 'A Cientista Negra' due to their scientific contributions. The municipal project for the culture of São Paulo is a program developed to enhance cultural initiatives.
Year(s) Of Engagement Activity 2020
URL https://www.caddecentre.org/a-cientista-negra/
 
Description Ester Sabino presented CADDE at ILP-FAPESP CYCLE # 1 - GENOMICS: THE SCIENCE OF LIFE 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact PI Ester Sabino presented CADDE efforts sequencing the SARS-CoV-2 genome in Brazil at the ILP-FAPESP event.
Year(s) Of Engagement Activity 2020
URL https://www.al.sp.gov.br/ilp/detalheAtividade.jsp?id=6006
 
Description Evolution and epidemic spread of SARS-CoV-2 in Brazil - Altmetric Attention Score 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact The publication 'Evolution and epidemic spread of SARS-CoV-2 in Brazil' achieved an Altmetric Attention score of 1145, it was mentioned by 67 news outlets, tweeted by 810 and has had 331 readers on Mendeley to date.
Year(s) Of Engagement Activity 2020,2021
URL https://science.sciencemag.org/content/369/6508/1255
 
Description First Genomic Epidemiology CADDE Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact We organized the First CADDE Genomic Epidemiology Workshop between the 2 to 6 December 2019) as a hands-on training course based on integrating virus sequencing data generated onsite with state of the art phylogenetic data analysis for outbreak investigation. The event was extremely successful and brought together over 70 people from >15 nationalities. New protocols were tested and at the request of the Brazilian Ministry of Health outbreak team, our collaborators from the ARTIC project presented their lab in a suitcase. This workshop sparked several questions and discussions during the daily poster sessions and afterwards. Several students have stayed in touch requesting new collaborations to be made throughout the Americas (Ecuador, Colombia, Mexico and Panama).
Year(s) Of Engagement Activity 2020
URL https://twitter.com/CaddeProject/status/1203106944313106432?s=20
 
Description First cases of coronavirus disease (COVID-19) in Brazil, South America (2 genomes, 3rd March 2020) - Virological Post 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact 'First cases of coronavirus disease (COVID-19) in Brazil, South America (2 genomes, 3rd March 2020)' posted in Virological.org in February 2020, has had over 77.9k views and is the 7th most viewed post of all time.
Year(s) Of Engagement Activity 2020
URL https://virological.org/t/first-cases-of-coronavirus-disease-covid-19-in-brazil-south-america-2-geno...
 
Description From Variants to Vaccine - A Picture of the Pandemic - UNESP International Symposium on Covid-19 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Mauricio Nogueira participated in the Unesp Covid Symposium entitled 'From Variants to Vaccine - A Picture of the Pandemic - UNESP International Symposium on Covid-19'
Year(s) Of Engagement Activity 2021
URL https://www.youtube.com/watch?v=2PyQLJ12r3g
 
Description Gene sleuths are tracking the coronavirus outbreak as it happens 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Several groups from around the world have seen the MIT Review highlighting our work in Brazil and have contacted us to support rapid sequencing in their countries. Moreover, this has also been noted by representatives of the World Health Organization who informally mentioned the global impact of our achievement due to several media outlets, including this MIT Review.
Year(s) Of Engagement Activity 2020
URL https://www.technologyreview.com/s/615317/gene-sleuths-are-tracking-the-coronavirus-outbreak-as-it-h...
 
Description Genome sequencing of the new coronavirus in 48 hours | Jaqueline Góes de Jesus | TEDxLaçador 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Jaqueline Góes de Jesus who coordinated the CADDE team that sequenced the genome of the new coronavirus in 48 hours, gave a talk at TEDX, reporting this feat and explaining the importance of distance and social isolation, respiratory etiquette and hygiene measures to flatten the number of cases curve.
Year(s) Of Engagement Activity 2020
URL https://www.ted.com/talks/jaqueline_goes_de_jesus_o_sequenciamento_do_genoma_do_novo_coronavirus_em_...
 
Description Genomic characterisation of an emergent SARS-CoV-2 lineage in Manaus: preliminary findings - Virological post 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact 'Genomic characterisation of an emergent SARS-CoV-2 lineage in Manaus: preliminary findings' posted in Virological Post, has had over 89.8K views (as of 03/21) and is the 6th most viewed post of all time. The research findings have been discussed in numerous news articles internationally, including but not limited to: New York Times, WION, Folha de S.Paulo, Timmerman Report, The Wall Street Journal, Evening Express, an Editorial in Science, Bloomberg, CNBC, News Medical Life Sciences, Science Focus, The Times, Reuters, Breaking News.ie, The Telegraph, L'Occhio, Indian financial times, BMJ, World Today News, The Economist, The Washington Post, Brazilian Report, The Financial Times, The Conversation.
Year(s) Of Engagement Activity 2021
URL https://virological.org/t/genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-manaus-preli...
 
Description Genomics and epidemiology of SARS-CoV-2 in Brazil - talk at Virus Genomics and Evolution 2021 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact At the Virus Genomics and Evolution 2021 conference held by Wellcome Connecting Science, Prof Nuno Faria presented 'Genomics and epidemiology of SARS-CoV-2 in Brazil' on behalf of CADDE.
Year(s) Of Engagement Activity 2021
 
Description Guidelines for international COVID19 genome sequencing (World Health Organization) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Pi Nuno Faria has been requested by the World Health Organization to lead the international guidelines for COVID19 genome sequencing.
Year(s) Of Engagement Activity 2020
 
Description How to trace virus histories to stop new outbreaks 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Media interview to discuss to wider public how genetic data can help us to prevent new outbreaks.
Year(s) Of Engagement Activity 2019
URL https://saude.abril.com.br/medicina/entrevista-como-entender-o-passado-dos-virus-para-impedir-novos-...
 
Description Interview for national news 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact 'Brazilians participate in some of the most important studies in the world against Covid'. CADDE PhD Candidate, Darlan Candido presents CADDE and SARS-CoV-2 phylogenetic tree in National TV Journal (>50% of share of TV viewers from Brazil).
Year(s) Of Engagement Activity 2020
URL https://g1.globo.com/jornal-nacional/noticia/2020/10/12/brasileiros-participam-de-alguns-dos-estudos...
 
Description Interview with Mayor and Health Secretary of Quixeramobim 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Darlan Candido participated in a facebook live 'Vaccine is Safe - A chat about the vaccine of COVID 19. Special Guest Darlan Cândido', with the mayor and health secretary of Quixeramobim city hall. The video is also available on youtube, and has been viewed over 12,000 times.
Year(s) Of Engagement Activity 2021
URL https://www.youtube.com/watch?v=jrRgi_k3ei0&t=4s
 
Description Invited seminar at InDRE - Mexican Ministry of Health 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact About 30 people attended an invited seminar. A strategic meeting with the Director of InDRE was held to formalize collaboration between CADDE and Mexican Ministry of Health.
Year(s) Of Engagement Activity 2020
 
Description Invited seminar at MRC Glasgow, United Kingdom 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Invited talk to discuss new CADDE collaborations with the MRC-University of Glasgow Centre for Virus Research. Four new collaborations have been made during a 6 hour-long visit to MRC-University of Glasgow Centre for Virus Research that will bring advances and will complement some of CADDE's main goals.
Year(s) Of Engagement Activity 2020
 
Description Know a female scientist? Nominate her for the Ester Sabino Award - USP Journal 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact The Ester Sabino Award was created to value scientific researchers in the State of Sao Paulo, named after the CADDE PI. Two female scientists will be honoured with this award this on the 11th February 2022. This was reported by USP Journal.
Year(s) Of Engagement Activity 2022
URL https://jornal.usp.br/universidade/conhece-uma-mulher-cientista-indique-a-para-o-premio-ester-sabino...
 
Description National News - Article describing the comment in The Lancet 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact News article from acritica.com on 28th January 2021 titled 'Scientists use Manaus to warn about Covid-19 variants' presenting the recent comment published in The Lancet "Covid-19 resurgence in Manaus, despite high seroprevalence". 'the publication is signed by 23 scientists, including Dr. Henrique Pereira, professor at the Federal University of Amazonas, and one of the organizers of Atlas ODS, one of the main references about the pandemic in the AM'.
Year(s) Of Engagement Activity 2021
URL https://www.acritica.com/channels/coronavirus/news/cientistas-usam-manaus-para-alertar-sobre-variant...
 
Description Nature News Feature 18-03-21 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact CADDE publications cited and researcher's quoted in a News Feature from the Journal Nature 'Five reasons why COVID herd immunity is probably impossible'.
Year(s) Of Engagement Activity 2021
URL https://www.nature.com/articles/d41586-021-00728-2
 
Description New York Times article 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Article published on Jan 9th in the New York Times 'As coronavirus mutates, the World stumbles again to respond' on the emerging variant in Brazil quoting PI Nuno Faria on the coordination of genomic sequencing in Brazil.
Year(s) Of Engagement Activity 2021
URL https://www.nytimes.com/2021/01/09/world/europe/coronavirus-mutations.html
 
Description Nuno Faria Interview with Sky News 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Nuno Faria did an interview with Sky News on the new P.1 lineage in Brazil, discussing the need to increase genomic surveillance across locations and countries directly linked by air travel to places where local transmission of these new lineages have occurred.
Year(s) Of Engagement Activity 2021
URL https://news.sky.com/video/covid-19-what-is-the-brazil-variant-12188021
 
Description Nuno Faria interview with Danish Newspaper 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Nuno Faria interview with Zetland - Danish Newspaper on 28/01/21, with article titled 'New mutations give us a glimpse of the future.We probably never get rid of corona, but we can learn to live with it'.
Year(s) Of Engagement Activity 2021
URL https://www.zetland.dk/historie/segJGy14-aekdaa3R-cef2b
 
Description Pandemic Scientists: Ester Sabino - Piauí, Fola De S.Paulo 'We need more women leading science' 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact In an article by Piauí, Folha De S.Paulo, Prof Ester Sabino is featured as a pandemic scientist and discusses CADDE research, the coordinated sequencing of coronavirus in Brazil and the need for more women leading science.
Year(s) Of Engagement Activity 2021
URL https://piaui.folha.uol.com.br/precisamos-de-mais-mulheres-liderando-ciencia/
 
Description Patients who have not been to Amazonas are detected with a Brazilian variant of the coronavirus in SP 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact 'Patients who have not been to Amazonas are detected with a Brazilian variant of the coronavirus in SP', a report by Fantástico, with the participation of Professor Ester Sabino.
Year(s) Of Engagement Activity 2021
URL https://globoplay.globo.com/v/9268646/
 
Description Plenary at the Universidade Federal do Oeste do Pará, Santarém, Brazilian Amazon 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Plenary talk at the Universidade Federal do Oeste do Pará, Santarém, Brazilian Amazon. A full room of nearly 100 students attended the talk which had a visible impact in the community. It stimulated younger generations to ask questions and established new collaborative links that will be important for understanding yellow fever origins in the Amazon and testing metagenomic approaches to discover new viruses.
Year(s) Of Engagement Activity 2019
URL https://twitter.com/CaddeProject/status/1205487167486808064?s=20
 
Description Press release Science Minister Amanda Solloway 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Our CADDE achievements have been quoted by the Science Minister Amanda Solloway who said (press release March 11, 2020):

"UK experts are leading the scientific and medical response to the global coronavirus outbreak, and we were one of the first countries to establish a laboratory test for the virus.

"By decoding the strain discovered in Latin America, the virus is giving up its secrets - giving scientists new insights into its origins, its travels and who has been infected. This will help accelerate the development of medicines, vaccines and strategies to combat it."
Year(s) Of Engagement Activity 2020
 
Description Rapid data sharing and its impact in research 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Opinion article on how rapid sharing of genomes can help reshape public health.
Year(s) Of Engagement Activity 2020
URL https://www.publico.pt/2020/01/24/ciencia/opiniao/partilha-rapida-genomas-virais-surto-impacto-imedi...
 
Description Rapid genome sequencing contributes to vaccine development 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Globo News, an audience leader among TV news channels, interviewed Prof. Ester Sabino, CADDE PI in Brazil, on sequencing and analyzing the first coronavirus cases in South America in less than 48 hours. The interview focused on the impact of virus genomic data for vaccine design and has potentially reached millions of viewers.
Year(s) Of Engagement Activity 2020
URL http://g1.globo.com/globo-news/videos/v/especialista-sobre-coronavirus-genoma-contribui-bastante-pro...
 
Description Science Media Centre news briefing 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Dr Nuno Faria, Dr Thomas Mellan, Prof Ester Sabino and Prof Sharon Peacock discussed new insights on the P.1 lineage, transmissibility, and immunity to members of the following news outlets at a Science Media Centre news briefing, titled 'The Brazil SARS-CoV-2 variant (Lineage P.1) - what we know so far':
BBC News
https://www.bbc.co.uk/news/health-56252779

Sky News
https://news.sky.com/story/brazilian-p1-variant-may-spread-more-easily-and-could-evade-immune-system-scientists-find-12233402

Yahoo News
https://uk.style.yahoo.com/brazil-variant-evades-61-immunity-113905217.html

Times
https://www.thetimes.co.uk/article/9790d8a0-7ba0-11eb-83b7-5869de54abef

Telegraph
https://www.telegraph.co.uk/news/2021/03/02/brazilian-covid-variant-not-major-threat-uk-experts-say/

Financial Times
https://www.ft.com/content/51cf718d-e701-4292-a9dd-dd36c1b1c5ea

Independent
https://edition.independent.co.uk/editions/uk.co.independent.issue.030321/data/9732413/index.html

Independent
https://www.independent.co.uk/news/health/covid-brazil-variant-cases-uk-latest-b1810333.html

Guardian
https://www.theguardian.com/world/2021/mar/02/brazil-variant-evaded-immunity-previous-covid-cases

PA via Yahoo
https://uk.finance.yahoo.com/news/manaus-variant-cause-reinfection-61-115837370.html

Reuters
https://www.reuters.com/article/health-coronavirus-brazilvariant/contagious-brazil-covid-19-variant-evades-immunity-scientists-warn-idINKCN2AU273

Mail Online
https://www.dailymail.co.uk/news/article-9315813/Coronavirus-Oxford-vaccine-professor-says-UK-ditch-obsession-Covid-variants.html

Daily Mail (US) and Reuters
https://www.dailymail.co.uk/health/article-9318985/Brazilian-coronavirus-variant-five-states-contagious.html

Mirror
https://www.mirror.co.uk/news/uk-news/brazil-covid-variant-could-reinfect-23590461

Evening Standard
https://www.standard.co.uk/news/health/brazil-covid-variant-reinfections-natural-immunity-b921810.html

Express
https://www.express.co.uk/news/uk/1404761/brazil-variant-news-manaus-strain-latest-uk-covid-infections-research-matt-hancock

Express
https://www.express.co.uk/news/politics/1404534/brazil-covid-case-uk-variant-south-east-england-strain-matt-hancock-latest

Metro
https://metro.co.uk/2021/03/02/brazil-variant-could-reinfect-61-of-people-whove-already-had-covid-14173026/

BioWorld
https://www.bioworld.com/articles/504302-study-identifies-brazil-sars-cov-2-variant-that-can-evade-protective-immunity

CNN
https://edition.cnn.com/world/live-news/coronavirus-pandemic-vaccine-updates-03-02-21/h_7184d55d3ec81f51b9e7b23a5c28e214

New York Times
https://www.nytimes.com/2021/03/01/health/covid-19-coronavirus-brazil-variant.html

The Wall Street Journal
https://www.wsj.com/articles/covid-19-variant-in-brazil-overwhelms-local-hospitals-hits-younger-patients-11614705337

The Globe and Mail
https://www.theglobeandmail.com/world/article-head-of-uk-program-that-tracks-covid-19-variants-says-virus-may-have/
Year(s) Of Engagement Activity 2021
 
Description Sky News article 'COVID-19: Brazilian P1 variant may spread more easily and could evade immune system, scientists find' 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Sky News published an article on 02 March titled 'COVID-19: Brazilian P1 variant may spread more easily and could evade immune system, scientists find' featuring the recent findings published by the CADDE Project.
Year(s) Of Engagement Activity 2021
URL https://news.sky.com/story/brazilian-p1-variant-may-spread-more-easily-and-could-evade-immune-system...
 
Description Speaker - Genomic, Evolutionary and Epidemiological Approaches for Pandemics - Newton Gateway to Mathematics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Prof Nuno Faria was a speaker at the Genomic, Evolutionary and Epidemiological Approaches for Pandemics, the Newton Gateway to Mathematics, University of Cambridge.
Year(s) Of Engagement Activity 2022
 
Description Ten Brazilian researchers tell what they are studying about the coronavirus 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact CNN Brazil article 'Ten Brazilian researchers tell what they are studying about the coronavirus' which included CADDE PI Ester Sabino and DPhil candidate, Darlan Candido. The article highlighted their research on SARS-CoV-2, particularly sequencing the coronavirus genome in just 48 hours.
Year(s) Of Engagement Activity 2020
URL https://www.cnnbrasil.com.br/saude/2020/04/11/dez-pesquisadores-brasileiros-contam-o-que-estao-estud...
 
Description The story of CADDE's research mapping SARS-CoV-2 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact The story of Cadde's research mapping SARS-CoV-2 published in the project, 'De Pelotas A Boa Vista: parcerias científicas para enfrentar a pandemia', along with 4 other highlighted research cases about Covid in Brazil. Cadde's is the first case; launched by Bori Agência on the 23 February.
Year(s) Of Engagement Activity 2021
URL https://wttventures.net/parcerias-cientificas-para-enfrentar-a-pandemia/
 
Description Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic - Altmetric Attention Score 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact The publication 'Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic' published in the Journal Science, has an Altmetric Attention Score of 5992. It has been captured in 296 news outlets, had 5599 tweeters, and 144 readers on Mendeley to date.
Year(s) Of Engagement Activity 2020,2021
URL https://science.sciencemag.org/content/early/2020/12/07/science.abe9728
 
Description Tracking COVID-19 in Brazil 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact The CADDE Project research on tracking SARS-CoV-2 in Brazil and generating the first COVID-19 genomes from South America is presented in a case study by the UKRI.
Key research papers are highlighted by the UKRI, emphasising the importance of developing partnerships with international collaborators to track infectious diseases.
Year(s) Of Engagement Activity 2021
URL https://www.ukri.org/our-work/tackling-the-impact-of-covid-19/our-global-contribution/tracking-covid...
 
Description Tracking the Evolution of a 'Variant of Concern' in Brazil - NIH Director's Blog 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The Director of the NIH, Dr. Francis Collins, in his Director's blog titled 'Tracking the evolution of a 'variant of concern' in Brazil' details research conducted by the CADDE Project on SARS-CoV-2 research, posted on April 27 2021.
Year(s) Of Engagement Activity 2021
URL https://directorsblog.nih.gov/2021/04/27/tracking-the-evolution-of-a-variant-of-concern-in-brazil/
 
Description Tweet by the NIH Director, Francis S. Collins sharing CADDE Research on SARS-CoV-2 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact The Director of the National Institute of Health, Dr. Francis S. Collins tweeted 'Despite Prior widespread infection in the Brazilian city of Manaus, the #coronavirus came roaring back for a second wave. A new study on the #P.1 variant shows how that was possible. #NIH #COVID19', sharing CADDE research on SARS-CoV-2 and P.1 variant of concern.
Year(s) Of Engagement Activity 2021
URL https://twitter.com/NIHDirector/status/1387059597270257665?s=20
 
Description Tweet from COVID-19 Technical Lead at the WHO, sharing CADDE research. 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Tweet by the WHO COVID-19 Technical Lead, Maria Van Kerkhove sharing the CADDE Virological post 'Genomic characterisation of an emergent SARS-CoV-2 lineage in Manaus: preliminary findings - SARS-CoV-2 coronavirus / nCoV-2019 Genomic Epidemiology - Virological'
Year(s) Of Engagement Activity 2021
URL https://twitter.com/mvankerkhove/status/1366605489916764161
 
Description Tweet from acting British Ambassador to Brazil 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Liz Davidson, acting British Ambassador to Brazil tweeted on the 26th January 2021, 'O Flag of United Kingdom is doing dedicated work to identify and monitor variants of the #COVID19 . Part of this task is the result of a very relevant exchange of knowledge with Brazil, with the brilliant scientists of the @CaddeProject'.
Year(s) Of Engagement Activity 2021
URL https://twitter.com/LizDavidson_UK
 
Description UKRI article 'Tracking COVID-19 in Brazil' 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact UKRI writes about CADDE and tracking the SARS-CoV-2 virus spread in Brazil: 'Tracking COVID-19 in Brazil'.
Year(s) Of Engagement Activity 2020
URL https://www.ukri.org/our-work/tackling-the-impact-of-covid-19/our-global-contribution/tracking-covid...
 
Description Washington Post Interviews and articles 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The Washington Post has written several articles following the work of CADDE researchers reaching an international audience. They feature quotes from Nuno Faria and links to Virological Post articles on P.1 and the situation in Manaus.

19 Jan 'Why the U.K.'s Mutated Coronavirus Is Fanning Worries' : https://www.washingtonpost.com/business/why-the-uks-mutated-coronavirus-is-fanning-worries/2021/01/19/ce2eb8da-5a2d-11eb-a849-6f9423a75ffd_story.html

21 Jan 'Why the Mutated Coronavirus Variants Are So Worrisome': https://www.washingtonpost.com/business/why-themutated-coronavirus-variants-are-soworrisome/2021/01/21/2b5f7abe-5bb2-11eb-a849-6f9423a75ffd_story.html

26 Jan 'Alarmingly transmissible Brazil virus variant in U.S' : http://thewashingtonpost.newspaperdirect.com/epaper/viewer.aspx

28 Jan 'The Amazonian city that hatched the Brazil variant has been crushed by it' : https://www.washingtonpost.com/world/2021/01/27/coronavirus-brazil-variant-manaus/
Year(s) Of Engagement Activity 2021
URL https://www.washingtonpost.com/world/2021/01/27/coronavirus-brazil-variant-manaus/
 
Description Why are female scientists forgotten by history? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Coordinator of the Brazilian team that sequenced the coronavirus genome (COVID-19) in record time, CADDE Postdoc Jaqueline Goes de Jesus gave a TEDx talk 'Por que cientistas mulheres são esquecidas pela história?' (Why are female scientists forgotten by history?) using the TED conference format, but independently organized by a local community.
Year(s) Of Engagement Activity 2020
URL https://www.youtube.com/watch?v=5vhXfr4H_uA
 
Description Yellow fever outbreak 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Interview to a general audience about how ongoing research in yellow fever can help us to prevent and anticipate the forthcoming outbreaks.
Year(s) Of Engagement Activity 2019
URL https://epoca.globo.com/novo-surto-de-febre-amarela-vira-em-cinco-anos-diz-pesquisador-de-oxford-237...
 
Description Yellow fever, dengue, Zika and chikungunya circulation in Brazil 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Media interview to discuss current arbovirus surveillance activities in Sao Paulo.
Year(s) Of Engagement Activity 2019
URL https://www.uol.com.br/vivabem/noticias/redacao/2019/07/29/febre-amarela-dengue-zika-e-chikungunya-q...