Maternal vitamin B12, folic acid and homocysteine as determinants of gestational diabetes, fetal growth and intergenerational programming of diabesity

Lead Research Organisation: University of Southampton
Department Name: Development Origin of Health and Disease

Abstract

There is a rapidly escalating epidemic of obesity and type 2 diabetes across the world, with the fastest rise occurring in low- and middle-income countries. India not only has one of the highest rates in the world, but the disease starts at a younger age and lower levels of body weight than in UK white caucasians. Among city-dwelling Indians, approximately 8% of people aged 30-40 years already have diabetes. This is creating a heavy burden of disease and disability, and an intolerable economic burden through medical costs and lost earnings. Until now, efforts to prevent diabetes have mainly focussed on modifying the diet, lifestyle and activity of at-risk adults (for example those who are overweight, have a family history of diabetes or already have high blood sugar). However, recent research has indicated that factors acting in early life (during development in the womb) place an individual at risk of later diabetes. These include maternal malnutrition and low birthweight, and diabetes in the mother during pregnancy. Our research has shown that Indian mothers often have low vitamin B12 levels, which in turn causes high blood levels of a harmful metabolite (homocysteine). We have shown that these mothers get more diabetes in pregnancy. Their children are more likely to born with a low birth weight, and develop more body fat and higher plasma insulin levels during childhood, which are signs of higher diabetes risk in later life. The risk is increased further if the mother has normal or high status for another B vitamin, folate. Thus, we have shown, for the first time a link between a specific nutritional deficiency in the mother and diabetes risk in the next generation. One possible mechanism for the effect of maternal nutrition on risk of diabetes in her children is through epigenetic effects, whereby the nutritional environment during early development affects the switches that control gene expression. Since these switches are passed on via either parent, we think it is possible that paternal vitamin B12 status could also be important.

Our proposed programme comprises 3 related projects in India and the UK:

1) A randomised controlled trial of vitamin B12 supplementation in a cohort of 700 rural Indian adolescents (Pune Maternal Nutrition Study) with the aim of improving their vitamin B12 status prior to marriage, conception and pregnancy.

The objectives are to determine

a) whether vitamin B12 supplementation of young Indian women improves the vitamin B12 status of their newborns.

b) whether vitamin B12 supplementation of young Indian women and men improves birth weight, neonatal body composition, and (beyond the time span of this grant) body composition and insulin sensitivity in the children.

2) A case-control study of mothers with gestational diabetes (N=700) and controls (N=1400) in a UK population with a high proportion of S Asians (Coventry, Nuneaton and Leicester).

The objective is to determine:

c) whether Indian and white caucasian women who develop GDM were more likely to have low vitamin B12 status, or an imbalance between B12 and folate (low B12, normal/high folate) in early pregnancy.

3) Measurement of vitamin B12, folate and homocysteine in stored maternal plasma samples from 3000 pregnancies in a UK birth cohort (Southampton Women's Survey) which has subsequently collected data on body composition in the newborns and children.

The objectives will be to determine:

d) whether lower maternal B12 status and higher homocysteine concentrations are associated with lower birthweight in a UK population.

e) whether B12-folate imbalance (low maternal B12 and normal/high folate status) are associated with a more adipose body composition at birth and during childhood.

We expect this unique research to have a major impact on future strategies to prevent diabetes.

Technical Summary

There is an escalating global epidemic of type 2 diabetes, with developing countries experiencing the most rapid increase. Current strategies for preventing the disease rely mainly on altering adult lifestyles. Recent research suggests that factors acting during early development, including fetal growth restriction, and exposure to gestational diabetes (GDM) in the mother, increase diabetes and obesity risk in later life. Our research in India has shown that maternal vitamin B12 deficiency and hyper-homocysteinaemia, in combination with normal/high folate status, is associated with an increased risk of GDM in the mother, growth restriction in her fetus, and adiposity and insulin resistance in her children. These effects could act through epigenetic mechanisms and occur in paternal as well as maternal B12 deficiency. Improving the B12 status of women and men preparing for pregnancy could be a scalable and affordable intervention to prevent diabetes in future generations. Our proposed programme includes an RCT of B12 supplementation in rural Indian adolescents who will marry and conceive within the next 4 years, aiming to improve newborn B12 status and body composition and reduce diabetes risk in their children. We will also carry out 2 observational studies in the UK, to replicate the earlier Indian findings and study their wider relevance. We will measure B12, folate and homocysteine in stored maternal samples from a UK birth cohort which has measured body composition in the children, and carry out a case-control study of mothers with and without GDM in a UK population at high risk and with a high S Asian population (W Midlands) to determine whether UK women who develop GDM have low B12 status, or B12/folate imbalance, in early pregnancy. Samples taken in all studies will be used for genetic studies, and future epigenetic research, relevant to our objectives. We expect this unique research to have a major impact on future strategies to prevent type 2 diabetes.

Planned Impact

This comprehensive programme will assess the impact of 2 B vitamins (B12 and folic acid) on metabolic risk of pregnant mothers, fetal growth and inter-generational programming of common chronic metabolic disorders (obesity and diabetes). We will assess impact in India, as well as in white Caucasians and South Asians living in the UK. We expect the work to have an influence on future strategies to prevent these disorders. This is important given the high burden of disease potentially caused by vitamin B12 deficiency and the scalable and affordable nature of widespread B12 supplementation. It is anticipated 15-20% of all pregnant mothers will develop GDM in the UK if the new International Association of Diabetes and Pregnancy Study Group (IADPSG) guidelines are adopted. Despite best efforts, childhood obesity is increasing along with the epidemic of metabolic disorders in adult life.

Apart from patients who develop GDM, the beneficiaries from this research will be: pregnant mothers of all ethnicities living in India, UK and elsewhere; diabetologists in the NHS and world-wide (if B12 deficiency predicts the risk of GDM); public health experts (involved in strategies to reduce childhood obesity); and policy makers (huge potential to reduce the burden of obesity and metabolic diseases of the next generation).

Publications

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Adaikalakoteswari A (2016) Simultaneous detection of five one-carbon metabolites in plasma using stable isotope dilution liquid chromatography tandem mass spectrometry. in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

 
Description Findings that have supported interventions in the first 1000 days
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact Caroline Fall and Clive Osmond are members of the COHORTS collaboration, which has carried out research that supports the targeting of nutritional interventions for the prevention of undernutrition in pregnancy and infancy.
 
Description Chancellor's scholarship
Amount £88,260 (GBP)
Organisation University of Warwick 
Sector Academic/University
Country United Kingdom
Start 10/2017 
End 09/2019
 
Description Department of Biotechnology, Government of India, Centre of Excellence Grant to Diabetes Research Unit, Pune, India (co-applicant K Kumaran)
Amount रू 70,000,000 (INR)
Organisation Ministry of Science and Technology India 
Department Department of Biotechnology, India
Sector Public
Country India
Start 12/2013 
End 11/2018
 
Description Research Fellows Training Scheme
Amount £226,500 (GBP)
Funding ID Fellows 
Organisation George Eliot Hospital NHS Trust 
Sector Public
Country United Kingdom
Start 03/2012 
End 10/2015
 
Description Translating cutting edge research from the University of Southampton into global health policy opportunities; a proposal to fund an intern to work with the World Health Organisation. KMG HI 2016
Amount £27,308 (GBP)
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 01/2016 
End 12/2016
 
Description WCPRS - University of Warwick and Industry collaborative scholarships (With BHR Pharmaceuticals)
Amount £96,549 (GBP)
Organisation University of Warwick 
Sector Academic/University
Country United Kingdom
Start 01/2018 
End 07/2021
 
Title Databases from 8 Indian birth cohorts 
Description Lifecourse data from 8 Indian birth cohorts. 
Type Of Material Database/Collection of data 
Provided To Others? Yes  
Impact Widening of research usage 
 
Description Maternal vitamin B12, folic acid and homocysteine as determinants of gestational diabetes, fetal growth and inter-generational programming of diabesity 
Organisation Council of Scientific and Industrial Research (CSIR)
Department Centre for Cellular and Molecular Biology (CCMB)
Country India 
Sector Academic/University 
PI Contribution Epidemiological and statistical expertise, study design, training of field and scientific staff, data interprtetation.
Collaborator Contribution Multi-disciplinary collaboration (paediatrics, obstetrics, diabetes, epidemiology, statistics, nutrition, genetics, biochemistry)
Impact 27076577. Multi-disciplinary collaboration (paediatrics, obstetrics, diabetes, epidemiology, statistics, nutrition, genetics, biochemistry). Abstracts presented at conferences. Study protocol paper for the Pune B12 interventio study ("PRIYA") published in BMC Nutrition 2017.
Start Year 2010
 
Description Maternal vitamin B12, folic acid and homocysteine as determinants of gestational diabetes, fetal growth and inter-generational programming of diabesity 
Organisation KEM Hospital Research Centre
Department Department of Diabetes
Country India 
Sector Hospitals 
PI Contribution Epidemiological and statistical expertise, study design, training of field and scientific staff, data interprtetation.
Collaborator Contribution Multi-disciplinary collaboration (paediatrics, obstetrics, diabetes, epidemiology, statistics, nutrition, genetics, biochemistry)
Impact 27076577. Multi-disciplinary collaboration (paediatrics, obstetrics, diabetes, epidemiology, statistics, nutrition, genetics, biochemistry). Abstracts presented at conferences. Study protocol paper for the Pune B12 interventio study ("PRIYA") published in BMC Nutrition 2017.
Start Year 2010
 
Description Maternal vitamin B12, folic acid and homocysteine as determinants of gestational diabetes, fetal growth and inter-generational programming of diabesity 
Organisation University of Oxford
Department Department of Pharmacology
Country United Kingdom 
Sector Academic/University 
PI Contribution Epidemiological and statistical expertise, study design, training of field and scientific staff, data interprtetation.
Collaborator Contribution Multi-disciplinary collaboration (paediatrics, obstetrics, diabetes, epidemiology, statistics, nutrition, genetics, biochemistry)
Impact 27076577. Multi-disciplinary collaboration (paediatrics, obstetrics, diabetes, epidemiology, statistics, nutrition, genetics, biochemistry). Abstracts presented at conferences. Study protocol paper for the Pune B12 interventio study ("PRIYA") published in BMC Nutrition 2017.
Start Year 2010
 
Description Maternal vitamin B12, folic acid and homocysteine as determinants of gestational diabetes, fetal growth and inter-generational programming of diabesity 
Organisation University of Warwick
Department Warwick Medical School
Country United Kingdom 
Sector Academic/University 
PI Contribution Epidemiological and statistical expertise, study design, training of field and scientific staff, data interprtetation.
Collaborator Contribution Multi-disciplinary collaboration (paediatrics, obstetrics, diabetes, epidemiology, statistics, nutrition, genetics, biochemistry)
Impact 27076577. Multi-disciplinary collaboration (paediatrics, obstetrics, diabetes, epidemiology, statistics, nutrition, genetics, biochemistry). Abstracts presented at conferences. Study protocol paper for the Pune B12 interventio study ("PRIYA") published in BMC Nutrition 2017.
Start Year 2010
 
Description Pune Children's Study 
Organisation KEM Hospital, Pune
Department Department of Paediatrics
Country India 
Sector Hospitals 
PI Contribution Contributions to study design, fieldwork training and quality control, data management, analysis and interpretation. Epidemiological, statistical and nutritional expertise.
Collaborator Contribution Expertise in long-term follow-up of birth cohorts, clinical and laboratory expertise. Day-to-day liaison with cohort members, fieldwork/data collection, data management, analysis and interpretation.
Impact Publications: 24874906, 25940643 and several abstracts presented at a major international meetings and published in peer-reviewed international journals.
Start Year 2006
 
Description Pune Maternal Nutrition Study 
Organisation KEM Hospital Research Centre
Department Department of Diabetes
Country India 
Sector Hospitals 
PI Contribution Contributions to study design, fieldwork training and quality control, data management, analysis and interpretation.Epidemiological, statistical and nutritional expertise.
Collaborator Contribution Expertise in community-based research, including interventions, in rural and urban settings in a developing country. Day-to-day liaison with cohort subjects, fieldwork management, data management, analysis and interpretation.
Impact 16480528, 16735496, 17032446, 17116720, 17620450, 17653070, 17851649, 19005641, 19498084, 19636321, 19776185, 20090113, 20103791, 20216560, 20675085, 21682572, 21731039, 22109280, 22323413, 22829248, 22941936, 22941936, 22941936, 22323413, 23349157, 23757425, 23920141, 24162586, 24459167, 25052622, 26902699 Abstracts presented at major international meetings and published in peer-reviewed international journals. Multi-disciplinary study: diabetes, paediatrics, obstetrics, radiology, nutrition, epidemiology, statistics
Start Year 2006
 
Title Vitamin B12 
Description Physiological doses of vitamin B12 for women and men before conception and (women) during pregnancy, to prevent adverse fetal programming 
Type Preventative Intervention - Nutrition and Chemoprevention
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2010
Development Status Under active development/distribution
Clinical Trial? Yes
Impact Trial ongoing. 
URL http://www.controlled-trials.com/ISRCTN32921044
 
Description "Meet the Expert Workshop" 2-4 December 2018, Kate Ward 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Kate Ward led a "Meet the Expert Workshop" at the 2018 National Osteoporosis Society Annual Conference which took place in Birmingham from 2nd to 4th December 2018
Year(s) Of Engagement Activity 2018
 
Description 2018 National Osteoporosis Society Annual Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A number of MRC LEU investigators attended the 2018 National Osteoporosis Society Annual Conference. Young Investigator Awards were received by Beth Curtis, Millie Parsons, Michael Clynes and Nick Fuggle. Kate Ward led a Meet the Expert Workshop and Professors Cyrus Cooper and Nick Harvey also gave major invited plenary presentations. Nick and Kate are also members of the Conference Organising Committee. There was a lot of social media activity surrounding this event.
Year(s) Of Engagement Activity 2018
 
Description 20th Annual Sneha Workshop, Feb 2017 (K Kumaran) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Indian meeting on DOHaD research attended by over 600 delegates and over 200 for the 2nd David Barker Memorial conference
Year(s) Of Engagement Activity 2017
 
Description 28th Seah Cheng Memorial Lecture, Singapore, 15-18th September 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Cyrus was invited to give the keynote address at the Academy of Medicine, Singapore on 'Osteoarthritis - from paediatric days to geriatric times'.
Year(s) Of Engagement Activity 2018
 
Description Address to a school audience, Mysore, India March 3016 (K Kumaran) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Chief guest: address to a school audience (students, teachers and parents) on the importance of early life nuturing to improve child development and later health. The school has subsequently asked Dr Kumaran to run regular sessions on adolescent health for the high school students
Year(s) Of Engagement Activity 2016
 
Description Annual Sneha conference, Lonavala, India, 2014 (K Kumaran) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Part of the organising team; attended by over 60 delegates for the main workshop and approx 150 for the David Barker Memorial Conference
Year(s) Of Engagement Activity 2014
 
Description Appointment to non-executive director of hospital trust 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact The University of Southampton Medicine News Page reported that Professor Cyrus Cooper has been appointed as non-executive director of hospital trust.
Year(s) Of Engagement Activity 2018
 
Description Article appeared in Healio with quotes by Nick Harvey regarding findings in his paper which was published in July 2018 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact An article appeared in healio with quotes by Nick Harvey regarding the findings in his paper which was published in July 2018
Year(s) Of Engagement Activity 2018
 
Description Article attracted great deal of media attention 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Hill WD, Marioni RE, Maghzian O, Ritchie SJ, Hagenaars SP, McIntosh AM, Gale CR, Davies GA combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence. Molecular psychiatry 2018/01/11 doi 10.1038/s41380-017-0001-5.
This article attracted a great deal of media attention - as well as appearing in a number of newspapers it was tweeted by 467 people, was on 7 facebook pages, mentioned in 3 Google+ posts, picked up by 14 news outlets, 4 Reddit and 2 videos, plus 54 readers on Mendeley.
Year(s) Of Engagement Activity 2018
 
Description Article entitled "higher inflammation in older age is linked to lower bone density" appeared in the University of Southampton medicine news and in the medicalexpress website 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Article entitled "higher inflammation in older age is linked to lower bone density" appeared in the University of Southampton medicine news and in the medicalexpress website
Year(s) Of Engagement Activity 2018
 
Description BBC Interview in Singapore for International News 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Cyrus Cooper gave an interview on BBC World News addressing recent advances in the risk assessment and treatment of osteoporosis.
Year(s) Of Engagement Activity 2018
 
Description Biostatistics and Epidemiology for Clinical and Public Health Research, Vellore, India, March 2016 and June 2016 (K Kumaran) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Faculty on a course for multi-disciplinary professionals run by Christian Medical College, Vellore in March and again in June 2016
Year(s) Of Engagement Activity 2016
 
Description Blog written by Cyrus Cooper and Nick Harvey which appeared in the Medically Spekaing section of the Unviersity of Southampton website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact Cyrus Cooper and Nick Harvey wrote a blog which appeared in the "Medically Speaking" section of the University of Southampton website. Their blog was about the National Osteoporosis Society Annual Osteoporosis Conference, at which four members of the MRC LEU, Beth Curtis, Millie Parsons, Nick Fuggle and Michael Clynes all received young investigator awards.
Year(s) Of Engagement Activity 2018
 
Description British Library Food Choices Event - HMI 2019 (2018) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact On 26th April 2018 Hazel Inskip was invited to take part in a panel discussion in front of an audience of paying guests on the topic "Food choices: What's on the Menu?". This attracted an audience of 180 people. She was on a panel with a Guardin food writer and a professional chef. A lively discussion was held and there was a lot of interest in what was said.
Year(s) Of Engagement Activity 2018
URL https://www.bl.uk/events/whats-on-the-menu-food-choices-in-contemporary-life
 
Description Calcium and Vitamin D supplementation are not associated with risk of incident ischemic cardiac events or death: findings from the UK Biobank Cohort - press release 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Press release created a lot of media interest for this paper.
Year(s) Of Engagement Activity 2018
 
Description Caroline Fall, K Kumaran, Sarah Kehoe; Organisers and chairs; 19th Annual Workshop of SNEHA India 2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Annual workshop in India on developmental origins of health and disease, under the aegis of SNEHA-INDIA (Society for natal effects on health in adults). This workshop brings senior researchers, multi-disciplinary research teams, under- and post-graduate students working on cohorts studies and trials from all over India together, along with international collaborators and invite speakers.
Year(s) Of Engagement Activity 2016
 
Description Caroline Fall: "Developmental origins of health and disease". Invited speaker to a lay audience; Nutrition of Girls and Women in Oregon, Moore Institute for Nutrition and Wellness, Portland, Oregon, USA, 14th May 2015. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Invited speaker to a lay audience; Nutrition of Girls and Women in Oregon, Moore Institute for Nutrition and Wellness, Portland, Oregon, USA, 14th May 2015.
Year(s) Of Engagement Activity 2015
 
Description Caroline Fall: "How is the memory of early life events retained, and how may it cause disease?" Invited plenary presentation at the 9th World Congress on Developmental Origins of Health and Disease, Capetown, South Africa, 8th November 2015. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact "How is the memory of early life events retained, and how may it cause disease?" Invited plenary presentation at the 9th World Congress on Developmental Origins of Health and Disease, Capetown, South Africa, 8th November 2015.
Year(s) Of Engagement Activity 2015
 
Description Caroline Fall: "The 'thin-fat' Indian and developmental origins of health and disease". Invited Keynote speaker, Wessex Paediatric Winter Meeting (organised by the Paediatric Innovation, Education and Research Network), Southampton General Hospital, 11th December 2015. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact "The 'thin-fat' Indian and developmental origins of health and disease". Invited Keynote speaker, Wessex Paediatric Winter Meeting (organised by the Paediatric Innovation, Education and Research Network), Southampton General Hospital, 11th December 2015.
Year(s) Of Engagement Activity 2015
 
Description Caroline Fall: "The environmental and developmental origins of health and disease (WHO CEH module)" and "Birth cohorts in India: An overview". Invited plenary speaker, PHFI-CHEP Workshop on Children's Environmental Health, Gurgaon, India, 23rd November 2015. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact "The environmental and developmental origins of health and disease (WHO CEH module)" and "Birth cohorts in India: An overview". Invited plenary speaker, PHFI-CHEP Workshop on Children's Environmental Health, Gurgaon, India, 23rd November 2015.
Year(s) Of Engagement Activity 2015
 
Description Caroline Fall: "The fetal origins of type 2 diabetes". Invited guest speaker to a lay audience, Center for Women's Health, Circle of Giving annual meeting, Portland, Oregon, USA,13th May 2015. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Invited guest speaker to a lay audience, Center for Women's Health, Circle of Giving annual meeting, Portland, Oregon, USA,13th May 2015.
Year(s) Of Engagement Activity 2015
 
Description Caroline Fall: "The first 1000 days". Invited plenary speaker, International Summit on the Nutrition of Adolescent Girls and Young Women, Moore Institute for Nutrition and Wellness, Portland, Oregon, USA, 16th May 2015. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited plenary speaker, International Summit on the Nutrition of Adolescent Girls and Young Women, Moore Institute for Nutrition and Wellness, Portland, Oregon, USA, 16th May 2015.
Year(s) Of Engagement Activity 2015
 
Description Caroline Fall: "Translating 'developmental origins' to benefit women and babies in low- and middle-income countries". Invited plenary speaker, 3rd Annual Harvard Catalyst Child Health Symposium, Boston, 7th October 2015. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact "Translating 'developmental origins' to benefit women and babies in low- and middle-income countries". Invited plenary speaker, 3rd Annual Harvard Catalyst Child Health Symposium, Boston, 7th October 2015.
Year(s) Of Engagement Activity 2015
 
Description Caroline Fall: Interviews with journalists at FIGO conference, Rome 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Wide public dissemination. The presentation reaced a large number of international obstetricians at their major annual conference. Presentation has been posted on the website of C3 for Health, for longer term dissemination to everyone interested in global health issues.

Requests to give further talks!
Year(s) Of Engagement Activity 2012
 
Description Caroline Fall: Invited presentation at NERC workshop on 'Early life developmental effects: unifying evolutionary and biomedical perspectives', Falmouth, 9th to 12th September 2015. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited presentation at NERC workshop on 'Early life developmental effects: unifying evolutionary and biomedical perspectives', Falmouth, 9th to 12th September 2015.
Year(s) Of Engagement Activity 2015
 
Description Caroline Fall: MRC Life Magazine article (Jun 2014) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact An article advertising the David Barker Commemorative meeting, "The Future of the Science David Barker Inspired", organised by MRC Lifecourse Epidemiology Unit and University of Southampton

Highlighting the commemorative event and work of the unit
Year(s) Of Engagement Activity
 
Description Clive Osmond: Inaugural lecture (May 2014) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Clive Osmond gate his inaugural lecture on 29 May 2014. It was entitled "Painting with numbers: exploring life's wonders"

Increased awareness of the work of the MRC LEU
Year(s) Of Engagement Activity
 
Description Cyrus Cooper and Keith Godfrey - Clarivate Highly Cited Researchers 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Both Cyrus Cooper and Keith Godfrey received congratulations for being among 2018s highly cited researchers. They were included in the Clarivate Analytics listings and also mentioned on the University of Southampton website.
Year(s) Of Engagement Activity 2018
 
Description Cyrus Cooper was interviewed for an article that was published in the Telegraph as a result of the paper that was published in the BMJ on Vitamin D. 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Cyrus Cooper was interviewed for an article that was published in the Telegraph as a result of the paper that was published in the BMJ on Vitamin D. His comments included: Cyrus Cooper, Professor of Rheumatology at the University of Southampton and President of the International Osteoporosis Foundation who contributed to the study said that bone density was probably some two to three times better at predicting someone's risk of getting osteoporosis than their level of Vitamin D level. "I don't think this paper debunks the idea that Vitamin D is useful", he said. "It's just that it is a small determinant. You'd do some good if you make sure that your Vitamin D levels are okay." Commenting on the current UK advice for management and prevention of osteoporosis he said: "The current guidelines are appropriate however a bone density evaluation needs to be done as part of fracture risk screening".
Year(s) Of Engagement Activity 2018
 
Description Engagement activity with Coventry and Warwickshire CCG 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Arden wide Annual CCG event - More than 200 people of varying sectors attended. Subsequent to this highly rated activity, a smaller CCG action group was formed and met in Feb 2019 to put action plan as a part of the next year's STP
Year(s) Of Engagement Activity 2018
 
Description Epidemiology for Clinicians course, Southampton, Jan 2017 (K Kumaran) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact On the Faculty of Epidemiology for Clinicians course hosted by University of Southampton, aimed at delegates with both clinical and non-clinical backgrounds who are interested in a career in epidemiological research
Year(s) Of Engagement Activity 2017
 
Description Fake Food Event Feedback 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Sian Robinson was one of the six panellists at the Fake Food event which took place at Lecture Theatre 1, SAB, Southampton General Hospital. The panel were asked questions by groups of local sixth formers who had been invited to the event.
Year(s) Of Engagement Activity 2018
 
Description Findings from the paper 'Calcium and Vitamin D supplementation are not associated with risk of incident ischemic cardiac events or death' appeared in the Hippocratic Post and other media 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Findings from the paper 'Calcium and Vitamin D supplementation are not associated with risk of incident ischemic cardiac events or death: Findings from the UK biobank cohort. J Bone Miner Res. 2018 May;33(5):803-811. doi: 10.1002/jbmr.3375, epub 2018 Feb 8'. appeared in the Hippocratic Post, on other websites, on 3 facebook pages, 34 tweets, and 1 blog.
Year(s) Of Engagement Activity 2018
 
Description Gestational vitamin D supplementation leads to reduced perinatal RXRA DNA methylation: results from the MAVIDOS trial - press release 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact https://www.southampton.ac.uk/medicine/news/2018/11/vitamin-d-baby-genes.page; https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbmr.3603
Gestational vitamin D supplementation leads to reduced perinatal RXRA DNA methylation: results from the MAVIDOS trial. Journal of Bone and Mineral Research. 2018 doi.10.1002/jbmr.3603
Curtis EM, Krstic N, Cook E, D'Angelo S, Crozier SR, Moon RJ, Murray R, Garratt Em, Costello P, Cleal J et al (inc Godfrey K, Cooper C and Harvey N).
Year(s) Of Engagement Activity 2018
 
Description Hertfordshire Public Meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Study participants or study members
Results and Impact Approximately 300 HLS participants and their families attended an open day, which led to discussion, questions and interest in future research studies.
Year(s) Of Engagement Activity 2018
 
Description High Commissioner, Singapore 17-18th September 2018 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact During the visit he was invited to a discussion on UK-Singapore research collaborations at Eden Hall, the residence of His Excellency Mr Scott Wightman, UK High Commissioner to Singapore.
Year(s) Of Engagement Activity 2018
 
Description Invited presentation at the 2nd annual PRIDE meeting, University of Warwick. Prof Caroline Fall "The Mumbai Maternal Nutrition Project" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited presentation at the 2nd annual PRIDE meeting, University of Warwick. November 2014
Year(s) Of Engagement Activity 2014
 
Description Invited presentation at the annual review meeting of the GIFTS consortium. Prof Caroline Fall "The Mumbai Maternal Nutrition Project" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited presentation at the annual review meeting of the GIFTS consortium, London, April 2014
Year(s) Of Engagement Activity 2014
 
Description Invited talk - Dissemination of preliminary results of PRiDE and STRiDE studies 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Nearly 200 people attended, with several national and international speakers
Year(s) Of Engagement Activity 2019
 
Description K Kumaran: 9th World Congress on Developmental Origins of Health and Disease, Cape Town, South Africa. 8-11 November 2015. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Four presentations to multi-disciplinary audience at 9th World Congress on Developmental Origins of Health and Disease, Cape Town, South Africa. 8-11 November 2015.
- Components of height and the intergenerational change in height as predictors of body composition and CVD risk in young Indian adults.
- Does change in components of childhood height influence cardiovascular risk and cognitive function in Indian adolescents?
- Stunting at 18 years is predicted by femur length in utero.
- Lifecourse evolution of diabetes related phenotypes.
Year(s) Of Engagement Activity 2015
 
Description Launch of Southampton India Centre 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact A day of presentations of research in Southampton related to India; presentations from all departments of the university. Attended by Indian High Commissioner and his team, major grant donors, media, staff and students from all faculties, general public. Official launch of University of Southampton India Centre for Sustainable Growth and Innovation.
Year(s) Of Engagement Activity 2019
 
Description MRC Festival of Medical Research 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact On 23rd June 2018 a number of MRC LEU staff (Prof Cyrus Cooper, Prof Hazel Inskip, Prof Elaine Dennison, Prof Sian Robinson, Gregorio Bevilcqua, Leo Westbury, Barbara Fariborz, Martin Stevens, Tina Horsfall, Holly Syddall, Kate Ward, Shirley Simmonds, Millie Parsons, Michael Clines, Vanessa Cox, Clare Harris, Harnish Patel and Ilsa Bloom) travelled to Hertfordshire for the MRC Festival of Medical Research where they held the Hertfordshire Cohort Study Open Day at Harpenden Public Halls. There were two sessions, one in the morning and the other in the afternoon. Many of the participants of the Hertfordshire study, their children and grandchildren attended the event which included a talk by Cyrus Cooper and hands on activities - refreshments were provided. An article appeared in MRC Life and another article about the open day was sent to Charlotte Campbell at UCL to be included in the CLOSER newsletter.
Year(s) Of Engagement Activity 2018
 
Description MRC Grant for £134K 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper and Nick Harvey were successful in securing an MRC Grant to the value of £134k which will fund a new dual energy x-ray absorptiometry (DXA) instrument and Mechanograph technology.
Year(s) Of Engagement Activity 2018
 
Description Media attention from release of paper 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact 'The impact of menopausal hormone therapy (MHT) on cardiac structure and function: insights from the UK biobank imaging enhancement study'. PLoS One 2018, March 8th.
Within a few days of being published this paper was within the top 5% of articles for this phenomenal almetrics score. The attention score showed 75 news outlets, 1 blog, 15 tweeters from around the world. Many newspapers picked up the story, including the Sun, The Daily Mirror, The Daily Mail, The Daily Star. It also appeared on a number of websites: Science Daily; Mayo Clinic, Queen Mary University of London, The Citizen and Deccan Chronicle, as well as those of the newspapers.
Year(s) Of Engagement Activity 2018
 
Description Meet the Scientist LifeLab 2017 - HMI 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact The sessions were with groups of up to 8 teenagers and Hazel carried out six sessions. Two on 3rd March 2017; 2 on 9th June 2017 and 2 on 20th November 2017. The idea was to engage the students with the excitement of working in science.
Year(s) Of Engagement Activity 2017
URL http://www.southampton.ac.uk/lifelab/
 
Description Member Expert Panel to review MSC Nutrition and Dietetics at Symbiosis School of Biomedical Sciences, Pune (K Kumaran) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Contributed to curriculum review and modification of MSC course at Symbiosis International University
Year(s) Of Engagement Activity 2016
 
Description NEWS: Dr Christopher Bell led the largest sequencing based analysis to date of genetically driven epigenetic variation in the human genome. 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact NEWS: Dr Christopher Bell (MRC-LEU & IDS), in collaboration with King's College London and BGI Shenzhen, has led the largest sequencing-based analysis to date of genetically driven epigenetic variation in the human genome. This work, published in Nature Communications, has implications for the functional dissection of common disease associated regions, as well as the interpretation of DNA methylation population studies.
Year(s) Of Engagement Activity 2018
 
Description National Diabetes in Pregnancy (DiP) Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This was organised by Prof P Saravanan, in collaboration with Diabetes UK and national DiP interest group. More than 350 professional participants attended. Highlighted the research Gaps in Gestational Diabetes and presented the preliminary results. Discussions and debate on key issue of how to manage GDM. Several positive feedback, including feedback on that it will change their practice
Year(s) Of Engagement Activity 2018
 
Description Newspaper and Magazine articles 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Wide dissemination to a lay readership

Raised public awareness
Year(s) Of Engagement Activity 2010,2011,2012
 
Description Newspaper article Daily Echo Research carried out in Southampton Hospitals - HMI 2019 (2018) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact On 27th July 2018 a newspaper article in the Southern Daily Echo stated that Southampton teaching hospitals are among the top performers in clinical research. More than 18,000 people took part in research studies at University Hospital Southampton some in collaboration with University of Southampton. The research includes studies which showed that diabetes, heart disease and cancer may be prevented by early interventions in nutrition and lifestyle of pregnant women, infants and children. Much of this research is carried out by the MRC Lifecourse Epidemiology Unit especially the nutrition and lifestyle of pregnant women, infants and children.
Year(s) Of Engagement Activity 2018
 
Description Newspaper articles in relation to LifeLab - HMI 2019 (2018) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact There were two newspaper articles, one under the heading of LEARNING FOR LIFE entitled "Government insight into city's LifeLab" which appeared on Thursday 28th June 2018 and the other on Wednesday 18th July 2018 under the heading LIFELAB SHOWCASE entitled "Celebration of a year in the LifeLab". These articles also appeared online.
Year(s) Of Engagement Activity 2018
URL https://www.dailyecho.co.uk/news/16361614.photos-celebrations-for-youngsters-over-years-successes-at...
 
Description Osteoporosis Review Editorial 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Entry for PURE: Editorial work: Elaine wrote an editorial for Osteoporosis Review. The Journal of the National Osteoporosis Society.
Year(s) Of Engagement Activity 2018
 
Description PPI and stakeholder meeting - University of Warwick 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 47 people (researchers, GPs, PPI representatives) attended the meeting which was help at University of Warwick. Emerging data from the UK GDM cohort was discussed alongside with the STRiDE study's rationale, plan and implementation and proposed rationale and plan for MAGIC in Malaysia
Year(s) Of Engagement Activity 2016
 
Description Paget's Information Event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Third sector organisations
Results and Impact Approximately 50 patients attended for an information afternoon, with Professor Elaine Dennison, which sparked questions and discussion with patients reporting better knowledge of their condition.
Year(s) Of Engagement Activity 2018
 
Description Paper appeared online in December 2017 after its press release, further media attention on 1.2.18 in MIMS 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This paper first appeared online in December 2017 after its press release. However, in 2018 it received further media attention on 1.2.18 in MIMS with an article entitled GP-led screening reduces hip fracture risk in older women and on 2.3.18 in Medical Health News net an article entitled FRAX: a nuanced tool for predicting fracture risk. There were also 149 tweets and 28 retweets.
Year(s) Of Engagement Activity 2018
 
Description Paper received a great deal of media interest, appearing on a number of websites 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact McLachlan JJ, Gale CR.
The effects of psychological distress and its interaction with socioeconomic position on risk of developing four chronic diseases. Journal of Psychosomatic Research. 2018; 109: 79-85.
This paper received a great deal of media interest, appearing on a number of websites, including: University of Southampton, the Daily Mail, University Hospitals Southampton, the Sun, ITV News, Medical News Today, reachmd.com, managed health care executive.com, anxious minds, the star and archyworldys. An article also appeared in the Daily Echo.
Year(s) Of Engagement Activity 2018
 
Description Podcast on Sarcopenia 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Health practitioners and pharmaceutical industry professionals listened to a podcast leading to discussion and follow up emails
Year(s) Of Engagement Activity 2018
 
Description Pregnancy Masterclass 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact As a part of South Asian Health Foundation (SAHF) annual Diabetes conference, an workshop on Pregnancy Masterclass was conducted. 60-70 GPs, Hospital practitioners and postgraduate students attended with several positive feedback on how their views will change re: Diabetes in Pregnancy
Year(s) Of Engagement Activity 2018
 
Description Presentations at St Swithans School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Approximately 10 sixth form students attended a talk about academic medicine which resulted in questions and discussion with follow up email correspondence, hosted by Professor Elaine Dennison on 3rd May 2018.
Year(s) Of Engagement Activity 2018
 
Description Press release followed by online publicity 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Gilbert T, Neuburger J, Kraindler J, Keeble E, Smith P, Arti C, Arora S, Street A, Parker S, Roberts HC, Bardsley M, Conroy S. Development and validation of a hospital frailty risk score focusing on older people in acute care settings using electronic hospital records: an observational study. Lancet 2018;391:1775-82.
Year(s) Of Engagement Activity 2018
 
Description Press release resulted in some media interest 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Pinedo-Villanueva R, Westbury LD, Syddall HE, Sanchez-Santos MT, Dennison EM, Robinson SM, Cooper C.
Health care costs associated with muscle weakness: a UK population based estimate. Calcified Tissue International. 2018; https://doi.org/10.1007/s00223-018-0478-1
A press release entitled "muscle weakness costs the UK £2.5 billion" resulted in some media attention, mostly on social media but also online and in the local press.
Year(s) Of Engagement Activity 2018
 
Description Press release resulting in online media attention 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact An atlas of genetic influences on osteoporosis in humans and mice. Nature Genetics https://doi.org/10. 1038/s41588-108-0302-x; https://www.uq.edu.au/news/article/2019/01/gene-map-offers-osteoporosis-hope

The paper was published on 31.12.18 and received a large amount of media attention. It is considered a ground breaking new study led by researchers from the Lady Davis Institute at the Jewish General Hospital. It has compiled an atlas of genetic factors associated with estimated bone mineral density.
Year(s) Of Engagement Activity 2018
 
Description Prof Caroline Fall: Disentangling the effects of weight and height gain in early life on chronic disease risk and human capital; data from 5 cohorts in low- and middle-income countries; the COHORTS collaboration 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation of the work of the COHORTS collaboration at the 17th Annual meeting of Sneha-India, Mysore, India, 2013
Year(s) Of Engagement Activity 2013
 
Description Professor Cyrus Cooper, Director of the MRC Lifecourse Epidemiology Unit interviewed by Wessex Monthly Magazine 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Professor Cyrus Cooper, Director of the MRC Lifecourse Epidemiology Unit was interviewed by the publication, Wessex Monthly Magazine, and explains how his research has translated into improvements in patient care and how continued exploration could lead to further discoveries in the next 70 years of the NHS. This was mentioned in the University e-news.
Year(s) Of Engagement Activity 2018
 
Description Public Health Platform Technical Advisory Group meeting, Pune, Mar 2016 (K Kumaran) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Part of a public health platform in India aimed at capacity building in public health
Year(s) Of Engagement Activity 2016
 
Description Pune Public Health Conference 2014, School of Health Sciences, University of Pune and Joint State Conference of IPHA-IAPSM (K Kumaran) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation to public health conference and IPHA-IAPSM on maternal health and pre-conceptional health
Year(s) Of Engagement Activity 2014
 
Description Social inequality and fractures - secular trends in the Danish population: a case control study. Osteoporosis International 2018;29:2243-50 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The findings of this paper received quite a bit of media attention with a number of comments being added to the online articles.
Year(s) Of Engagement Activity 2018
 
Description Social media: Lifelab Meet the Scientist 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact Using Twitter to disseminate information about the work at the MRC LEU both from the MRC LEU account and my account SHKehoe

Lifelab Meet the Scientists - regular presentations to school children about work as a scientist
Year(s) Of Engagement Activity 2016,2017,2018,2019
 
Description Southampton General Hospital Open Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact We offered two activities suitable for adults and children - measuring grip strength and making an x-ray of the hand with clay. The open day was extremely well attended and we had great interest in both the activities and also our research ongoing within the Unit, particularly among undergraduate students and their parents. People reported changes in their views and opinions and asked for further information.
Year(s) Of Engagement Activity 2018
 
Description The MRC Festival Zone, 4-29th June 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact "I'm a Scientist get me out of here", part of the MRC Festival Zone from 4th-29th June 2018 with over 1,300 students and their teachers taking part. This involved a 30 minutes live webchat where pupils were able to ask any questions they wanted and there was also the ability for students to ask further questions via the ASK function of the website. During the 4 week event Millie took part in 30 of the 30 minute webchats (15 hours in total) and then responded to a further 58 questions. The intention of the event is to encourage children to consider the importance of science and demonstrate the career options open to them in science.
Year(s) Of Engagement Activity 2018
 
Description The Opening of Southampton Paget's Centre of Excellence 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact On Thursday 31st May 2018 the MRC Lifecourse Epidemiology Unit in Southampton hosted an event to celebrate being awarded Centre of Excellence status for the Paget's Association. There was a press release and the event was recorded online, in social media and had a two page spread in Paget's News (August 2018).
Year(s) Of Engagement Activity 2018
 
Description Twitter Tweets for Recurrent back pain during working life and exit from paid employment: a 28 year follow up of the Whitehall II study. 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Lallukka T, Many M, Cooper C, Fleischmann M, Kouvonen A, Walker-Bone KE, Head JA, Halonen JI. Recurrent back pain during working life and exit from paid employment: a 28 year follow up of the Whitehall II study. Occup Environ Med. 2018; 75: 786-91.
This paper received a number of tweets putting it in the top 25% of all research outputs scored by Altmetric.
Year(s) Of Engagement Activity 2018
 
Description Wearing white for World Cancer Day 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Media (as a channel to the public)
Results and Impact 16 members of staff took part in the University of Southampton's "Wear White for World Cancer Day" with more making donations. Altogether the MRC LEU donated £41.
Year(s) Of Engagement Activity 2018
 
Description Website and enews 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact McLachlan KJJ, Gale CR. The effects of pshychological distress and its interaction with socioeconomic position on risk of developing four chronic diseases. Journal of Psychosomatic Research. 2018; 109:79-85.
The findings of the paper co-authored by Catherine Gale received a lot of media attention appearing on a number of websites.
Year(s) Of Engagement Activity 2018
 
Description Wellcome Trust Award 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact £1.6 m Wellcome Trust award and using data from the UK Biobank, is intended to reduce the impact of these common musculoskeletal disorders by providing a basis for improved means of disease prediction, prevention and treatment. The project, led by Jon Tobias, Professor of Rheumatology at Bristol Medical School, will involve a collaboration between researchers from the University of Southampton, as well as Bristol, Manchester, Aberdeen, Cardiff and Queensland Universities.

News of this award attracted media attention and was on a number of websites.
Year(s) Of Engagement Activity 2018
 
Description What is DOHaD and where is it going? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact 2nd David Barker Memorial Symposium in India on Developmental Origins of Health and Disease, held at the Integrated Research School for Health Affairs, Bharati Vidyapeeth University, Pune, India. A lecture for clinicians on what DOHaD is all about, and its relevance for cinical care.
Year(s) Of Engagement Activity 2017