Developmental origins of child neurodevelopment: Novel approaches to clinical risk prediction using an international metadataset.
Lead Research Organisation:
University of Oxford
Department Name: Paediatrics
Abstract
Approximately 1 in 10 children under 5 years of age, globally, are at risk of delayed development. The lifecourse impact of this is substantial with cognitive, motor and language delays, and behavioural problems, during early childhood, associated with poorer educational attainment, lower personal finances, poorer physical health and increased risk of substance abuse and mental illness during adulthood.
There is strong evidence that the period between conception and the child's 3rd birthday is 'a golden window of opportunity' for brain development. Brain stimulation activities during the early postnatal years, when compared with others administered at older ages, have been shown to have the greatest and most enduring beneficial impact on educational, health and economic outcomes through childhood and adult life.
While it is technically challenging to assess cognitive, language and motor skills at birth and during very early life, a number of foetal, birth-related and childhood factors (such as foetal growth, prematurity, child growth, health, and social environment) have been associated with these outcomes during early childhood. However, these associations are not universally observed, and different patterns have been reported from populations in different countries. Moreover, studies have used different techniques to assess child development, limiting the comparability between them.
Understanding, in international populations, the risk factors associated with development delay are key to identifying, as early as possible, children at risk of delay. Where neurodevelopmental assessments are not feasible (such as in the newborn or in resource-limited settings) or limited in sensitivity (such as during infancy), the use of risk profiles presents an alternative, low-cost strategy for the identification children at risk and for the appropriate targeting of interventions. However, as yet, there is no such risk-prediction tool for developmental delay that can be applied during very early life and across international populations.
To address these issues, my project will bring together data already collected from 9 studies to examine, across high-, middle- and low-income countries, the associations between growth, health and environmental influences, in the period between conception and the child's second birthday, on cognitive, motor, language and behavioural outcomes at 2 years. Taken together, this metadataset will represent 8,015 children from 13 countries (Brazil, DRC, Finland, Grenada, Guatemala, India, Italy, Kenya, Pakistan, Thailand, Slovakia, South Africa and the UK). Importantly, child development at 2 years is measured, in all contributing studies, on one standardised development test (the INTER-NDA).
I will undertake statistical analyses to quantify the association between multiple early life influences and developmental delay at 2 years and study how these factors interact with each other to modify risk. I will apply statistical and machine-learning approaches to group risk factors into clusters and use these to construct models to predict, at birth and at 1 year, the risk for developmental delay at 2 years. I will evaluate the performance of this risk-model in an independent dataset (not included in the metadataset, and in which developmental milestones were not assessed at 2 years on the INTER-NDA) of 500 children from the Mysore, India.
This project will significantly benefit researchers and clinicians working in child health, across high-, middle- and low-income countries, by (1) extending the understanding of the risk factors associated with early developmental delay and (2) construction of a tool with which to predict, during early life, the risk of developmental delay. Identifying children at risk of developmental delay early, in order to target treatment strategies within sensitive window of brain development, is key to preventing the loss of developmental potential in children.
There is strong evidence that the period between conception and the child's 3rd birthday is 'a golden window of opportunity' for brain development. Brain stimulation activities during the early postnatal years, when compared with others administered at older ages, have been shown to have the greatest and most enduring beneficial impact on educational, health and economic outcomes through childhood and adult life.
While it is technically challenging to assess cognitive, language and motor skills at birth and during very early life, a number of foetal, birth-related and childhood factors (such as foetal growth, prematurity, child growth, health, and social environment) have been associated with these outcomes during early childhood. However, these associations are not universally observed, and different patterns have been reported from populations in different countries. Moreover, studies have used different techniques to assess child development, limiting the comparability between them.
Understanding, in international populations, the risk factors associated with development delay are key to identifying, as early as possible, children at risk of delay. Where neurodevelopmental assessments are not feasible (such as in the newborn or in resource-limited settings) or limited in sensitivity (such as during infancy), the use of risk profiles presents an alternative, low-cost strategy for the identification children at risk and for the appropriate targeting of interventions. However, as yet, there is no such risk-prediction tool for developmental delay that can be applied during very early life and across international populations.
To address these issues, my project will bring together data already collected from 9 studies to examine, across high-, middle- and low-income countries, the associations between growth, health and environmental influences, in the period between conception and the child's second birthday, on cognitive, motor, language and behavioural outcomes at 2 years. Taken together, this metadataset will represent 8,015 children from 13 countries (Brazil, DRC, Finland, Grenada, Guatemala, India, Italy, Kenya, Pakistan, Thailand, Slovakia, South Africa and the UK). Importantly, child development at 2 years is measured, in all contributing studies, on one standardised development test (the INTER-NDA).
I will undertake statistical analyses to quantify the association between multiple early life influences and developmental delay at 2 years and study how these factors interact with each other to modify risk. I will apply statistical and machine-learning approaches to group risk factors into clusters and use these to construct models to predict, at birth and at 1 year, the risk for developmental delay at 2 years. I will evaluate the performance of this risk-model in an independent dataset (not included in the metadataset, and in which developmental milestones were not assessed at 2 years on the INTER-NDA) of 500 children from the Mysore, India.
This project will significantly benefit researchers and clinicians working in child health, across high-, middle- and low-income countries, by (1) extending the understanding of the risk factors associated with early developmental delay and (2) construction of a tool with which to predict, during early life, the risk of developmental delay. Identifying children at risk of developmental delay early, in order to target treatment strategies within sensitive window of brain development, is key to preventing the loss of developmental potential in children.
Technical Summary
Approximately 250 million children under 5 years, worldwide, are at risk of delayed development. Early neurodevelopmental delays (ENDs) are associated with poorer educational, economic, and health outcomes across the lifecourse. As developmental interventions during this period have enduring positive impacts, identifying children at risk early is key to targeting interventions within this window of sensitivity.
While it technically challenging to assess neurocognitive skills during early infancy, the use of risk profiles presents an alternative, low-cost strategy for the identification of children at risk. However, as yet, there is no such tool to identify, at scale and across international populations, children at high risk of ENDs. Multiple prenatal, perinatal and postnatal risk factors (including prematurity, growth, and health) have been associated with ENDs. However, patterns of associations vary between populations limiting the generalisability of findings.
Understanding risk factors associated with developmental delay, is key to identifying, as early as possible, children at high risk of delay. To study this, I will bring together already collected data from 9 studies, representing 8,015 children from 13 high-, middle- and low-income countries. For all children, neurodevelopment at 2 years was measured on the INTER-NDA test. I will examine associations between early risk factors and ENDs using hierarchical association analyses; identify risk clusters and construct models to predict risk of developmental delay during early childhood. I will validate these models in an independent study from Mysore, India (n=500). My hypothesis is that these risk models will satisfactorily predict ENDs, and if proven, I will translate these findings into a tool for early identification of developmental delay.
This project leverages on established collaborations with data contributors and the epidemiological expertise of Southampton's MRC Lifecourse Epidemiology Unit.
While it technically challenging to assess neurocognitive skills during early infancy, the use of risk profiles presents an alternative, low-cost strategy for the identification of children at risk. However, as yet, there is no such tool to identify, at scale and across international populations, children at high risk of ENDs. Multiple prenatal, perinatal and postnatal risk factors (including prematurity, growth, and health) have been associated with ENDs. However, patterns of associations vary between populations limiting the generalisability of findings.
Understanding risk factors associated with developmental delay, is key to identifying, as early as possible, children at high risk of delay. To study this, I will bring together already collected data from 9 studies, representing 8,015 children from 13 high-, middle- and low-income countries. For all children, neurodevelopment at 2 years was measured on the INTER-NDA test. I will examine associations between early risk factors and ENDs using hierarchical association analyses; identify risk clusters and construct models to predict risk of developmental delay during early childhood. I will validate these models in an independent study from Mysore, India (n=500). My hypothesis is that these risk models will satisfactorily predict ENDs, and if proven, I will translate these findings into a tool for early identification of developmental delay.
This project leverages on established collaborations with data contributors and the epidemiological expertise of Southampton's MRC Lifecourse Epidemiology Unit.
Organisations
- University of Oxford (Collaboration, Lead Research Organisation, Project Partner)
- John Radcliffe Hospital (Collaboration)
- Chris Hani Baragwanath Hospital (Collaboration)
- University of Colorado Denver (Collaboration, Project Partner)
- Umea University (Collaboration)
- Aga Khan Hospital (Collaboration)
- Beijing Obstetrics and Gynecology Hospital (Collaboration)
- Swedish Medical Center (Collaboration)
- Global Alliance to Prevent Prematurity and Stillbirth (Collaboration)
- Kenyan Institute for Medical Research (KEMRI) (Collaboration)
- Ministry of Health Sultanate of Oman (Collaboration)
- Windward Islands Research & Education Foundation (Collaboration)
- Hospital of the University of Health and Science of Turin (Collaboration)
- Starlab (Collaboration)
- Providence Regional Medical Center Everett (Collaboration)
- Research Institute of Child Psychology and Psychopathology (Collaboration)
- Stanford University (Collaboration)
- Polytechnic University of Catalonia (Collaboration)
- Ketkar Hospital (Collaboration)
- University of Sharjah (Collaboration)
- International Atomic Energy Agency (Collaboration)
- University of Southampton (Collaboration)
- Holdsworth Memorial Hospital, Mysore (Collaboration)
- Cesta Von (Collaboration)
- University of Turku (Collaboration)
- University of Paris - Descartes (Collaboration)
- University College London (Collaboration)
- United Arab Emirates University (Collaboration)
- Aga Khan University (Collaboration)
- Aga Khan University Hospital (Collaboration)
- University of Turin (Collaboration)
- Mahidol University (Collaboration)
- University of Washington (Collaboration)
- University Hospital Southampton NHS Foundation Trust (Collaboration)
- Federal University of Pelotas (UFPel) (Collaboration)
- University Hospital Southampton NHS Foundation Trust (Project Partner)
- University of Turku (Project Partner)
- University of Southampton (Project Partner)
- WINDREF (Windward Islands Res & Edu Fdn) (Project Partner)
- Aga Khan University (Pakistan) (Project Partner)
- NIHR Centre for Biomedical Research (Project Partner)
- CSI Holdsworth Memorial Hospital (Project Partner)
- Road out (Cesta von) (Project Partner)
Publications
Ariff S
(2024)
Differential associations between body composition indices and neurodevelopment during early life in term-born infants: findings from the Pakistan cohort: Multi-Center Body Composition Reference Study.
in European journal of clinical nutrition
Benz F
(2025)
Early neurophysiological markers of aberrant auditory processing associated with increased risk of autism spectrum disorder: A systematic review
in Pediatric Investigation
Berg K
(2024)
Causes of Musculoskeletal Pain in Paget's Disease of Bone
in Calcified Tissue International
Bevilacqua G
(2024)
General self-efficacy, not musculoskeletal health, was associated with social isolation and loneliness in older adults during the COVID-19 pandemic: findings from the Hertfordshire Cohort Study.
in Aging clinical and experimental research
Fernandes M
(2025)
A community-based intervention (the Omama Project) improves neurodevelopment in impoverished 2-year-old Roma children: a quasi-experimental observational study.
in European journal of pediatrics
Fernandes M
(2024)
50 Studies Every Neonatologist Should Know
Filteau S
(2024)
Associations of linear growth with body composition of perinatally HIV-infected African adolescents.
in The British journal of nutrition
Gregson CL
(2024)
Perinatal HIV infection is associated with deficits in muscle function in children and adolescents in Zimbabwe.
in AIDS (London, England)
Hageman SHJ
(2024)
Prediction of individual lifetime cardiovascular risk and potential treatment benefit: development and recalibration of the LIFE-CVD2 model to four European risk regions.
in European journal of preventive cardiology
Related Projects
| Project Reference | Relationship | Related To | Start | End | Award Value |
|---|---|---|---|---|---|
| MR/V029169/1 | 01/11/2021 | 03/03/2024 | £364,325 | ||
| MR/V029169/2 | Transfer | MR/V029169/1 | 04/03/2024 | 31/10/2028 | £229,830 |
| Title | Promotional video to support selection as finalist for the MRC Impact Prize: Early Career Impact 2024 |
| Description | Promotional video to support my selection as finalist for the MRC Impact Prize: Early Career Impact 2024, created by the Department of Paediatrics University of Oxford and edited by UKRI Creative Services. This brief video explained the reason for my nomination and the impact of my research in developing scalable tools and building capacity in early child development assessments globally. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2024 |
| Impact | Presentation at the MRC Impact Prize Awards ceremony |
| URL | https://www.youtube.com/watch?v=mKMcD3opDEE |
| Description | Contribution to international early child development monitoring policy in the capacity of technical expert on the WHO's Global Scales of Early Child Development Project Consultative Group (PCG) |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | INTER-NDA toolkit endorsed for neonatal neurodevelopment follow-up by the British Association of Perinatal Medicine |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| Impact | Since this endorsement, plans are in place to train developmental follow-up teams from the neonatal units in four trusts and for a national webminar about the INTER-NDA toolkit: https://www.bapm.org/events/the-inter-nda-toolkit-a-rapid-standardised-neurodevelopmental-assessment |
| URL | https://www.bapm.org/events/the-inter-nda-toolkit-a-rapid-standardised-neurodevelopmental-assessment |
| Description | Led revision of THAMES VALLEY & WESSEX GUIDELINES FOR ASSESSMENT AND INITIATION OF THERAPEUTIC HYPOTHERMIA (COOLING) TREATMENT FOR BABIES PRESENTING WITH MODERATE OR SEVERE HYPOXIC ISCHAEMIC ENCEPHALOPATHY |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Contribution to new or improved professional practice |
| Description | Multiple international OX-NDA training sessions |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | These training sessions equipped non-specialist field workers with the necessary skills in standardized neurodevelopment assessments to enable them to identify children at risk of developmental delay within the first year of life at scale, so as to target interventions effectively. |
| Description | Presentation at national Education Forum policy conference |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| Description | Training of international teams in the INTER-NDA neurodevelopment assessment |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Detailed training, reliability testing and standardization of assessors in multiple countries in a rapid, standardized, psychometrically valid test for early child development (the INTER-NDA) whose development and dissemination I have led since 2014. |
| Description | Training of two international research and clinical teams in the Neo-NBA |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Improved educational and skill level of workforce - both research and clinical - in the neurological and neurobiobehavioural assessment of newborns in a standardized, rapid and scalable manner so as to identify newborns at risk of developmental and neurological problems as early as possible. |
| Description | Virtual training sessions for the INTER-NDA and Neo-NBA |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Training of non specialists from 5 countries in a rapid, standardized neonatal neurobiobehavioural assessment to detect babies at risk of developmental delay and neurological abormality as early as possible |
| Description | Fetal brain maturation, infant feeding and neurodevelopment: Influences on sleep patterns of 2-year old children in geographically diverse populations |
| Amount | £64,700 (GBP) |
| Funding ID | 900-5376 |
| Organisation | The Waterloo Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2024 |
| End | 09/2025 |
| Description | MRC Clinical Research Training Fellowship |
| Amount | £444,497 (GBP) |
| Funding ID | MR/V029169/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2021 |
| End | 10/2028 |
| Description | Sa~o Paulo T21 Birth Cohort Study: longitudinal study of health and development of children with Down syndrome in the city of Sa~o Paulo |
| Amount | R$Â 72,761,250 (BRL) |
| Funding ID | 2022/12022-8 |
| Organisation | São Paulo Research Foundation (FAPESP) |
| Sector | Public |
| Country | Brazil |
| Start | 07/2023 |
| End | 08/2027 |
| Title | INTER-NDA e-calculator |
| Description | A web-app for the easy recording of INTER-NDA item scores, with automated calculation of standardized domain scores, their interpretation and rapid identification of children at risk of severe cognitive, language, fine motor and/or gross motor delay; and behavioural problems, at age 2 years. Open source, very user-friendly, web-based (no download required), accessible on multiple devices with need for special software/settings, results downloadable in PDF format, GDPR compliant - no data stored, no personal information collected Limitation: available in English only, suitable only for individual assessments - not suitable for research study group calculations https://inter-nda.shinyapps.io/inter-nda/ I led the design of this app and oversaw its coding and development by my colleague Dr Young I led piloting and testing of the app and its international launch and dissemination |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | Multiple international users including clinical and research staff Being applied in the NIHR-funded INTER-NEO study for the follow-up of high risk NICU graduates at University Hospitals Southampton NHS Foundation Trust |
| URL | https://inter-nda.shinyapps.io/inter-nda/ |
| Title | OX-NDA E-form |
| Description | Web-based form to assist with data collection when applying the OX-NDA test to measure developmental outcomes in 1 year olds |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Web-based form to assist with data collection and test administration Easy data entry with integrated QCs to prevent missing and multiple entries Easy data upload and download, including automated datasheet creation in csv format |
| Title | The Neonatal Neurobehavioral Assessment (Neo-NBA) |
| Description | The Neonatal Neurobehavioural Assessment (Neo-NBA) is a novel, neonatal neurobiobehavioural assessment that measures neurodevelopment, neuromotor, behavioural, responsivity to stimuli, vision and hearing outcomes in babies aged 0-4 weeks. It is a mixed-methodology assessment and is based on techniques of direct assessment, direct observation, and caregiver reports. It consists of 5 conceptual elements: (1) a structured clinical neurological examination, (2) a behavioural and neuromotor assessment, (3) an assessment of responsivity to stimuli, (4) an assessment of vision and hearing and (5) a caregiver-reported behaviour questionnaire. Its 37 items are scored on a 5-point scale. Its items were designed to map onto neurodevelopment domains frequently assessed in older children (cognition, language, motor and behaviour domains) and to be comparable with the HHNE; the NBAS and the Prechtl assessment of general movements. The total duration of the newborn assessment is aimed to be 20-30 minutes. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Validation study ongoing in Turin Italy |
| Title | First international actigraphy-based preschool sleep metadataset |
| Description | This dataset is the first prospective, international, standardised, infant sleep meta-dataset, representing 791 children from eight geographically and culturally diverse populations. The dataset contains longitudinal, growth, health, neurodevelopment, vision and sleep data from two existing cohorts: The INTERGROWTH-21st Project6 (healthy, low-risk mother-child dyads, n=24) and INTERBIO-21st Study7 (medium- to high-risk mother-child dyads, n=514) from study sites in Brazil, India, Italy, Kenya, Pakistan, South Africa, Thailand and the UK. In addition to socio-environmental, maternal health, child health, growth, nutritional and environmental variables, the dataset contains information on: 1) Sleep Parameters: (a) Sleep Quantity: sleep timing (onset, offset), sleep period (SP), total sleep time (TST), SP and TST in 24 hours; (b) Sleep Quality: Sleep %, Fragmentation Index; (c) Circadian Rest-Activity Parameters: Relative Amplitude, Intra-Daily Variability; (d) Parent reported infant sleep disturbances. 2) Neurodevelopment: (a) At 2 years: (i) INTER-NDA continuous scores and presence of severe, mild-to-moderate and no delay for cognitive, language, gross motor, fine motor, positive behavior and negative behavior domains; (ii) low visual acuity and contrast sensitivity scores (b) At 1 and 2 years: (i) age of acquisition of motor milestones and (ii) presence of motor delay. 3) Indices of fetal brain maturity: Total brain volume, cerebral cortex (and lobular) volumes, choroid plexus volume, cerebellar volume, cortical plate surface area and regional morphological asymmetry index from 18 to 26 gestational weeks. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2024 |
| Provided To Others? | No |
| Impact | Ongoing analysis: (1) To further mechanistic understanding of the association between child sleep and neurodevelopment by examining: (a) if sleep patterns among 2-year old children at low NDD risk are similar across diverse populations and (b) associations between disordered sleep and NDDs, in the light of key socioecological drivers. (2) To identify early markers of disordered child sleep by: (a) examining ultrasound markers of fetal brain maturation and (b) characterising high-risk phenotypes that predict both disordered sleep and NDD risk at 2 years of age so as to provide targeted interventions. 2 x publications submitted, 1 x manuscript in preparation, analysis for 4th manuscript ongoing 1 x research grant from Waterloo Foundations Engagement with the sleep charity and with relevant special interest groups such as the ESRS, BSS, BAPM and the RCPCH ICHG to disseminate findings planned after first 2 publications. |
| Title | INTERBIO-21st Project: Neurodevelopment database |
| Description | Neurodevelopment database of the INTERBIO-21st Project which contains INTER-NDA raw and domain scores from 3000 2-year-old children from the study sites in Brazil, Italy, Kenya (Kilifi and Nairobi), South Africa, Pakistan, Thailand and the UK. The database also contains information on the children's birth outcomes; growth, health and nutritional outcomes during the 1st two years of life; children's environments, maternal health and nutritional outcomes and fetal scans. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | This database is still being organised, and cleaned. Analysis will begin shortly. |
| Title | Neo-NBA validation dataset |
| Description | Dataset containing data on (i) neonatal neurobehavioural assessments (for a new tool, the Neo-NBA and validation assessment, the HNNE) and (ii) socio-demographic, pre-, peri- and neonatal characteristics on preterm and term babies assessed between 0-5 days of life in Turin, Italy |
| Type Of Material | Database/Collection of data |
| Year Produced | 2024 |
| Provided To Others? | No |
| Impact | Ongoing analysis validating the Neo-NBA against the HNNE for term and preterm babies |
| Title | Neurodevelopmental outcomes in Zika exposed children |
| Description | Database of neurodevelopment outcomes of children exposed to the Zika virus during intra-uterine life in the island nation of Grenada, West Indies during the peak of the 2015-2016 Zika epidemic there. These children were assessed on the OX-NDA and INTER-NDA developmental assessments, which I have authored, and which I have trained, standardised and supervised the local teams in. This database also contains information on the mothers' and children's ZIKA status post birth, children's anthropometry and health information and information on the children's home environment. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | 1) Analysis of data to characterise the spectrum of neurodevelopment in Zika exposed children |
| Title | Neurodevelopmental outcomes in children exposed to the Chikungunya virus during intra-uterine life |
| Description | Database consisting of neurodevelopment outcomes of children exposed to the Chikungunya virus during intra-uterine life, from the island nation of Grenada, West Indies. This dataset includes information on the children's age, sex, birth outcomes, infection status, health and growth outcomes. The neurodevelopment assessment consisted of the INTER-NDA, the novel test which I have authored and which I trained and standardised the local team in. It also contains data on the Cardiff tests of vision, and EEG data to assess cortical auditory processing, which I also trained the team in. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | No |
| Impact | 1) Profiling the spectrum of child developmental outcomes in children exposed to the Chikungunya virus during various periods of development, including during intra-uterine life 2) Determining whether Chikungunya exposure / infection is associated with adverse child developmental outcomes at age 2 years 3) Communication of results to public health authorities in Grenada and to the general public to encourage the promotion of measures to prevent exposure. |
| Title | The BRAINENDEVR early child development international metadataset |
| Description | This dataset, funded by an MRC CRTF towards the project titled "Developmental Origins of Child Neurodevelopment: Novel approaches to clinical risk prediction using an international meta-dataset", contains detailed data from early fetal life through to 2 years on heath, maternal, socio-environmental, growth and development indicators including detailed developmental outcomes measured on the INTER-NDA test at age 2 years in 5797 children from 13 countries. Data on over 500 variables is represented in the dataset. This is the first International metadatset of its kind in the field of early child development, and focusses on the environmental determinants of developmental risk during the first 1000 days if life in International populations of children. All information is de-identified, and the dataset was constructed (merged, harmonized, and standardized) according to the INSPIRE guidelines. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2025 |
| Provided To Others? | No |
| Impact | Ongoing analysis: I. To examine and quantify, in the metadataset, risk factors for NDD at 2 Y: i. To examine and quantify the risk contribution of growth, health and environmental risk factors during the prenatal, perinatal and postnatal periods to cognitive, language and motor delay at 2Y measured on the INTER-NDA. ii. To identify clusters of risk factors with the greatest predictive value for NDD at 2 Y. iii. To determine whether differential risk clusters exist based on sex and country. II. To develop and validate clinical risk prediction models for NDD at 2Y: i. To construct models of clinical risk prediction, at birth and at 1 year, for NDD at 2Y. ii. To test these models for reproducibility and evaluate their predictive ability in children participating in a study not included in the meta-dataset (the Mysore Parthenon Birth Cohort, India) and in whom 2Y developmental milestones were not measured on the INTER-NDA. Advanced statistical and data science techniques are being employed for these analyses. |
| URL | http://www.brainendevr.org/ |
| Title | The FinnBrain Birth Cohort Study |
| Description | This database includes detailed prospective data on child health, growth and brains development from early fetal life to 9 years of age in a cohort of prospectively recruited children from Turku, Finland. Data collection is still ongoing and will be collected beyond the 9 year time point. The data includes detailed psychometric, clinical, neuroendocrinological and neuro-imaging information from these children. As a collaborator on the FinnBrain project, which has utilised the INTER-NDA (the novel tool which I have authored) in its 2 year follow-up of children, I am working closely with this team on the analysis of all reproach questions which involve the 2 year assessment. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | No |
| Impact | 1) Understanding the mechanisms governing child brain development in the context of maternal stress during pregnancy 2) Correlating early child outcome measures with outcomes during middle and late childhood 3) Elucidating windows of vulnerability during child brain development during the early years. |
| Title | The INTER-NDA consortium |
| Description | This is a collection of neurodevelopment data for children aged 2 years assessed with the INTER-NDA tool. The database is populated from assessments carried out by the adopters (research groups/institutions) through the NeuroApp, in real-time. All data are anonymised prior to upload into the consortium database. Key variables including gender, date of birth, date of assessment and study location are not anonymised. The aim is to eventually utilise the INTER-NDA consortium database to inform living / contemporaneous reference ranges for the INTER-NDA domains (cognitivee, language, motor, behaviour, attention and social-emotional). |
| Type Of Material | Database/Collection of data |
| Year Produced | 2014 |
| Provided To Others? | No |
| Impact | None at the moment |
| URL | https://www.inter-nda.com/database.html |
| Title | The INTERGROWTH-21st Project Neurodevelopment Database |
| Description | Collection of cognitive, motor, language, behavioural, vision, EEG and sleep data from 1300 children from the study sites in Brazil, India, Italy, Kenya and the UK. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2013 |
| Provided To Others? | No |
| Impact | Used for the creation of the INTERGROWTH-21st INTER-NDA standards of early child development. |
| Description | Developmental Origins of Child Neurodevelopment: Novel approaches to clinical risk prediction using an international meta-dataset |
| Organisation | Aga Khan University |
| Country | Pakistan |
| Sector | Academic/University |
| PI Contribution | 1) I led the proposal design and funding application, and was responsible for securing funding for this exciting project 2) I led all aspects of the research methodology and design including protocol development, data management and statistical analysis plan 3) I led the ethics application and obtained approval from the University's ethics community 4) I led the execution of collaboration agreements and MTAs with all data sharing partners 5) I led all aspects of dataset template creation, data requests, data consistency and completion checks for all contributor datasets 6) Together with CIRU I led the construction of the Project's bespoke secure data hosting platform 7) Together with CIRU I led the the construction harmonization and standardization of the metadataset 8) Together with CIRU I led the analysis of neurodevelopment data for the identification of novel phenotypes of developmental delay 9) I am currently leading the statistical analysis of this project involving both regression and tree-based approaches 10) I lead all PPI activities for this Project 11) I will be responsible for all reports and publication outputs, and other research outputs including creating of a web app for the risk estimator and dissemination activities - I am currently working on the first 2 papers relating to this project (a cohort profile and a commentary on ethics considerations in the use of big data and data science for early child development research) |
| Collaborator Contribution | 1) Data sharing of raw datasets 2) Technical advice on the datasets 3) Mentorship (Turku and Oxford) in child psychiatry, paediatric neuroscience and early child development 4) Collaborative efforts in data science, data analysis and data management with CIRU team at Southampton |
| Impact | This collaboration is multi-disciplinary, disciplines involved are: 1. Paediatrics and child health 2. Child Development and Psychology 3. Child Psychiatry 4. Paediatric Neuroscience 5. Perinatal Epidemiology 6. Global Child Health 7. Data Science 8. Data Sharing 9. Neonatal Medicine 10. Statistics 11. Public Health Research outputs so far: 1) Project website 2) Ethics approval 3) Data synthesis and standardization protocols and management plans 4) Compilation of first international early child development metadataset 5) Keynote presentations at international conferences including NeuroDays (University of Aix Marseille, France) and FinnBrain Congress (University of Turku, Finland) |
| Start Year | 2021 |
| Description | Developmental Origins of Child Neurodevelopment: Novel approaches to clinical risk prediction using an international meta-dataset |
| Organisation | Cesta Von |
| Country | Slovakia |
| Sector | Charity/Non Profit |
| PI Contribution | 1) I led the proposal design and funding application, and was responsible for securing funding for this exciting project 2) I led all aspects of the research methodology and design including protocol development, data management and statistical analysis plan 3) I led the ethics application and obtained approval from the University's ethics community 4) I led the execution of collaboration agreements and MTAs with all data sharing partners 5) I led all aspects of dataset template creation, data requests, data consistency and completion checks for all contributor datasets 6) Together with CIRU I led the construction of the Project's bespoke secure data hosting platform 7) Together with CIRU I led the the construction harmonization and standardization of the metadataset 8) Together with CIRU I led the analysis of neurodevelopment data for the identification of novel phenotypes of developmental delay 9) I am currently leading the statistical analysis of this project involving both regression and tree-based approaches 10) I lead all PPI activities for this Project 11) I will be responsible for all reports and publication outputs, and other research outputs including creating of a web app for the risk estimator and dissemination activities - I am currently working on the first 2 papers relating to this project (a cohort profile and a commentary on ethics considerations in the use of big data and data science for early child development research) |
| Collaborator Contribution | 1) Data sharing of raw datasets 2) Technical advice on the datasets 3) Mentorship (Turku and Oxford) in child psychiatry, paediatric neuroscience and early child development 4) Collaborative efforts in data science, data analysis and data management with CIRU team at Southampton |
| Impact | This collaboration is multi-disciplinary, disciplines involved are: 1. Paediatrics and child health 2. Child Development and Psychology 3. Child Psychiatry 4. Paediatric Neuroscience 5. Perinatal Epidemiology 6. Global Child Health 7. Data Science 8. Data Sharing 9. Neonatal Medicine 10. Statistics 11. Public Health Research outputs so far: 1) Project website 2) Ethics approval 3) Data synthesis and standardization protocols and management plans 4) Compilation of first international early child development metadataset 5) Keynote presentations at international conferences including NeuroDays (University of Aix Marseille, France) and FinnBrain Congress (University of Turku, Finland) |
| Start Year | 2021 |
| Description | Developmental Origins of Child Neurodevelopment: Novel approaches to clinical risk prediction using an international meta-dataset |
| Organisation | Holdsworth Memorial Hospital, Mysore |
| Country | India |
| Sector | Hospitals |
| PI Contribution | 1) I led the proposal design and funding application, and was responsible for securing funding for this exciting project 2) I led all aspects of the research methodology and design including protocol development, data management and statistical analysis plan 3) I led the ethics application and obtained approval from the University's ethics community 4) I led the execution of collaboration agreements and MTAs with all data sharing partners 5) I led all aspects of dataset template creation, data requests, data consistency and completion checks for all contributor datasets 6) Together with CIRU I led the construction of the Project's bespoke secure data hosting platform 7) Together with CIRU I led the the construction harmonization and standardization of the metadataset 8) Together with CIRU I led the analysis of neurodevelopment data for the identification of novel phenotypes of developmental delay 9) I am currently leading the statistical analysis of this project involving both regression and tree-based approaches 10) I lead all PPI activities for this Project 11) I will be responsible for all reports and publication outputs, and other research outputs including creating of a web app for the risk estimator and dissemination activities - I am currently working on the first 2 papers relating to this project (a cohort profile and a commentary on ethics considerations in the use of big data and data science for early child development research) |
| Collaborator Contribution | 1) Data sharing of raw datasets 2) Technical advice on the datasets 3) Mentorship (Turku and Oxford) in child psychiatry, paediatric neuroscience and early child development 4) Collaborative efforts in data science, data analysis and data management with CIRU team at Southampton |
| Impact | This collaboration is multi-disciplinary, disciplines involved are: 1. Paediatrics and child health 2. Child Development and Psychology 3. Child Psychiatry 4. Paediatric Neuroscience 5. Perinatal Epidemiology 6. Global Child Health 7. Data Science 8. Data Sharing 9. Neonatal Medicine 10. Statistics 11. Public Health Research outputs so far: 1) Project website 2) Ethics approval 3) Data synthesis and standardization protocols and management plans 4) Compilation of first international early child development metadataset 5) Keynote presentations at international conferences including NeuroDays (University of Aix Marseille, France) and FinnBrain Congress (University of Turku, Finland) |
| Start Year | 2021 |
| Description | Developmental Origins of Child Neurodevelopment: Novel approaches to clinical risk prediction using an international meta-dataset |
| Organisation | University of Colorado Denver |
| Department | Anschutz Medical Campus |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | 1) I led the proposal design and funding application, and was responsible for securing funding for this exciting project 2) I led all aspects of the research methodology and design including protocol development, data management and statistical analysis plan 3) I led the ethics application and obtained approval from the University's ethics community 4) I led the execution of collaboration agreements and MTAs with all data sharing partners 5) I led all aspects of dataset template creation, data requests, data consistency and completion checks for all contributor datasets 6) Together with CIRU I led the construction of the Project's bespoke secure data hosting platform 7) Together with CIRU I led the the construction harmonization and standardization of the metadataset 8) Together with CIRU I led the analysis of neurodevelopment data for the identification of novel phenotypes of developmental delay 9) I am currently leading the statistical analysis of this project involving both regression and tree-based approaches 10) I lead all PPI activities for this Project 11) I will be responsible for all reports and publication outputs, and other research outputs including creating of a web app for the risk estimator and dissemination activities - I am currently working on the first 2 papers relating to this project (a cohort profile and a commentary on ethics considerations in the use of big data and data science for early child development research) |
| Collaborator Contribution | 1) Data sharing of raw datasets 2) Technical advice on the datasets 3) Mentorship (Turku and Oxford) in child psychiatry, paediatric neuroscience and early child development 4) Collaborative efforts in data science, data analysis and data management with CIRU team at Southampton |
| Impact | This collaboration is multi-disciplinary, disciplines involved are: 1. Paediatrics and child health 2. Child Development and Psychology 3. Child Psychiatry 4. Paediatric Neuroscience 5. Perinatal Epidemiology 6. Global Child Health 7. Data Science 8. Data Sharing 9. Neonatal Medicine 10. Statistics 11. Public Health Research outputs so far: 1) Project website 2) Ethics approval 3) Data synthesis and standardization protocols and management plans 4) Compilation of first international early child development metadataset 5) Keynote presentations at international conferences including NeuroDays (University of Aix Marseille, France) and FinnBrain Congress (University of Turku, Finland) |
| Start Year | 2021 |
| Description | Developmental Origins of Child Neurodevelopment: Novel approaches to clinical risk prediction using an international meta-dataset |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | 1) I led the proposal design and funding application, and was responsible for securing funding for this exciting project 2) I led all aspects of the research methodology and design including protocol development, data management and statistical analysis plan 3) I led the ethics application and obtained approval from the University's ethics community 4) I led the execution of collaboration agreements and MTAs with all data sharing partners 5) I led all aspects of dataset template creation, data requests, data consistency and completion checks for all contributor datasets 6) Together with CIRU I led the construction of the Project's bespoke secure data hosting platform 7) Together with CIRU I led the the construction harmonization and standardization of the metadataset 8) Together with CIRU I led the analysis of neurodevelopment data for the identification of novel phenotypes of developmental delay 9) I am currently leading the statistical analysis of this project involving both regression and tree-based approaches 10) I lead all PPI activities for this Project 11) I will be responsible for all reports and publication outputs, and other research outputs including creating of a web app for the risk estimator and dissemination activities - I am currently working on the first 2 papers relating to this project (a cohort profile and a commentary on ethics considerations in the use of big data and data science for early child development research) |
| Collaborator Contribution | 1) Data sharing of raw datasets 2) Technical advice on the datasets 3) Mentorship (Turku and Oxford) in child psychiatry, paediatric neuroscience and early child development 4) Collaborative efforts in data science, data analysis and data management with CIRU team at Southampton |
| Impact | This collaboration is multi-disciplinary, disciplines involved are: 1. Paediatrics and child health 2. Child Development and Psychology 3. Child Psychiatry 4. Paediatric Neuroscience 5. Perinatal Epidemiology 6. Global Child Health 7. Data Science 8. Data Sharing 9. Neonatal Medicine 10. Statistics 11. Public Health Research outputs so far: 1) Project website 2) Ethics approval 3) Data synthesis and standardization protocols and management plans 4) Compilation of first international early child development metadataset 5) Keynote presentations at international conferences including NeuroDays (University of Aix Marseille, France) and FinnBrain Congress (University of Turku, Finland) |
| Start Year | 2021 |
| Description | Developmental Origins of Child Neurodevelopment: Novel approaches to clinical risk prediction using an international meta-dataset |
| Organisation | University of Southampton |
| Department | Clinical Informatics Research Unit |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | 1) I led the proposal design and funding application, and was responsible for securing funding for this exciting project 2) I led all aspects of the research methodology and design including protocol development, data management and statistical analysis plan 3) I led the ethics application and obtained approval from the University's ethics community 4) I led the execution of collaboration agreements and MTAs with all data sharing partners 5) I led all aspects of dataset template creation, data requests, data consistency and completion checks for all contributor datasets 6) Together with CIRU I led the construction of the Project's bespoke secure data hosting platform 7) Together with CIRU I led the the construction harmonization and standardization of the metadataset 8) Together with CIRU I led the analysis of neurodevelopment data for the identification of novel phenotypes of developmental delay 9) I am currently leading the statistical analysis of this project involving both regression and tree-based approaches 10) I lead all PPI activities for this Project 11) I will be responsible for all reports and publication outputs, and other research outputs including creating of a web app for the risk estimator and dissemination activities - I am currently working on the first 2 papers relating to this project (a cohort profile and a commentary on ethics considerations in the use of big data and data science for early child development research) |
| Collaborator Contribution | 1) Data sharing of raw datasets 2) Technical advice on the datasets 3) Mentorship (Turku and Oxford) in child psychiatry, paediatric neuroscience and early child development 4) Collaborative efforts in data science, data analysis and data management with CIRU team at Southampton |
| Impact | This collaboration is multi-disciplinary, disciplines involved are: 1. Paediatrics and child health 2. Child Development and Psychology 3. Child Psychiatry 4. Paediatric Neuroscience 5. Perinatal Epidemiology 6. Global Child Health 7. Data Science 8. Data Sharing 9. Neonatal Medicine 10. Statistics 11. Public Health Research outputs so far: 1) Project website 2) Ethics approval 3) Data synthesis and standardization protocols and management plans 4) Compilation of first international early child development metadataset 5) Keynote presentations at international conferences including NeuroDays (University of Aix Marseille, France) and FinnBrain Congress (University of Turku, Finland) |
| Start Year | 2021 |
| Description | Developmental Origins of Child Neurodevelopment: Novel approaches to clinical risk prediction using an international meta-dataset |
| Organisation | University of Turku |
| Country | Finland |
| Sector | Academic/University |
| PI Contribution | 1) I led the proposal design and funding application, and was responsible for securing funding for this exciting project 2) I led all aspects of the research methodology and design including protocol development, data management and statistical analysis plan 3) I led the ethics application and obtained approval from the University's ethics community 4) I led the execution of collaboration agreements and MTAs with all data sharing partners 5) I led all aspects of dataset template creation, data requests, data consistency and completion checks for all contributor datasets 6) Together with CIRU I led the construction of the Project's bespoke secure data hosting platform 7) Together with CIRU I led the the construction harmonization and standardization of the metadataset 8) Together with CIRU I led the analysis of neurodevelopment data for the identification of novel phenotypes of developmental delay 9) I am currently leading the statistical analysis of this project involving both regression and tree-based approaches 10) I lead all PPI activities for this Project 11) I will be responsible for all reports and publication outputs, and other research outputs including creating of a web app for the risk estimator and dissemination activities - I am currently working on the first 2 papers relating to this project (a cohort profile and a commentary on ethics considerations in the use of big data and data science for early child development research) |
| Collaborator Contribution | 1) Data sharing of raw datasets 2) Technical advice on the datasets 3) Mentorship (Turku and Oxford) in child psychiatry, paediatric neuroscience and early child development 4) Collaborative efforts in data science, data analysis and data management with CIRU team at Southampton |
| Impact | This collaboration is multi-disciplinary, disciplines involved are: 1. Paediatrics and child health 2. Child Development and Psychology 3. Child Psychiatry 4. Paediatric Neuroscience 5. Perinatal Epidemiology 6. Global Child Health 7. Data Science 8. Data Sharing 9. Neonatal Medicine 10. Statistics 11. Public Health Research outputs so far: 1) Project website 2) Ethics approval 3) Data synthesis and standardization protocols and management plans 4) Compilation of first international early child development metadataset 5) Keynote presentations at international conferences including NeuroDays (University of Aix Marseille, France) and FinnBrain Congress (University of Turku, Finland) |
| Start Year | 2021 |
| Description | Developmental Origins of Child Neurodevelopment: Novel approaches to clinical risk prediction using an international meta-dataset |
| Organisation | Windward Islands Research & Education Foundation |
| Country | Grenada |
| Sector | Charity/Non Profit |
| PI Contribution | 1) I led the proposal design and funding application, and was responsible for securing funding for this exciting project 2) I led all aspects of the research methodology and design including protocol development, data management and statistical analysis plan 3) I led the ethics application and obtained approval from the University's ethics community 4) I led the execution of collaboration agreements and MTAs with all data sharing partners 5) I led all aspects of dataset template creation, data requests, data consistency and completion checks for all contributor datasets 6) Together with CIRU I led the construction of the Project's bespoke secure data hosting platform 7) Together with CIRU I led the the construction harmonization and standardization of the metadataset 8) Together with CIRU I led the analysis of neurodevelopment data for the identification of novel phenotypes of developmental delay 9) I am currently leading the statistical analysis of this project involving both regression and tree-based approaches 10) I lead all PPI activities for this Project 11) I will be responsible for all reports and publication outputs, and other research outputs including creating of a web app for the risk estimator and dissemination activities - I am currently working on the first 2 papers relating to this project (a cohort profile and a commentary on ethics considerations in the use of big data and data science for early child development research) |
| Collaborator Contribution | 1) Data sharing of raw datasets 2) Technical advice on the datasets 3) Mentorship (Turku and Oxford) in child psychiatry, paediatric neuroscience and early child development 4) Collaborative efforts in data science, data analysis and data management with CIRU team at Southampton |
| Impact | This collaboration is multi-disciplinary, disciplines involved are: 1. Paediatrics and child health 2. Child Development and Psychology 3. Child Psychiatry 4. Paediatric Neuroscience 5. Perinatal Epidemiology 6. Global Child Health 7. Data Science 8. Data Sharing 9. Neonatal Medicine 10. Statistics 11. Public Health Research outputs so far: 1) Project website 2) Ethics approval 3) Data synthesis and standardization protocols and management plans 4) Compilation of first international early child development metadataset 5) Keynote presentations at international conferences including NeuroDays (University of Aix Marseille, France) and FinnBrain Congress (University of Turku, Finland) |
| Start Year | 2021 |
| Description | Evaluation of the Neonatal Neurobehavioural Assessment (Neo-NBA) in identifying risk of developmental delay in newborns |
| Organisation | Hospital of the University of Health and Science of Turin |
| Country | Italy |
| Sector | Hospitals |
| PI Contribution | I am the author of the Neo-NBA and led the design of this study validating it against the HNNE in term and preterm babies. I have trained the team in the Neo-NBA and have been involved in all aspects of research methodology including protocol development and designs, ethics application, and the training of teams. I am leading the data analysis and report writing. |
| Collaborator Contribution | Contributions to research methodology including protocol development and designs, ethics application, and data collection. Training and standardization of team Project set up and implementation Research Governance and ethics Participant recruitment Preliminary analysis |
| Impact | Pilot data analysis (unplublished) International virtual training workshop 24/7/2023 attending by 18 persons from 6 countries Implementation in (i) INTERPRACTICE-21st study in 4 countries and (ii) UAE Birth cohort Study (UAE) |
| Start Year | 2022 |
| Description | Fetal brain maturation, infant feeding and neurodevelopment: Influences on sleep patterns of 2-year old children in geographically diverse populations |
| Organisation | Umea University |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | (1) Construction of the first prospective, international, standardised, infant sleep meta-dataset, representing 791 children from eight geographically and culturally diverse populations; (2) Description of the first transcultural sleep times, patterns and phenotypes during early childhood to guide risk estimation and clinical recommendations; (3) Improved understanding of the associations between sleep, environment and neurodevelopment during early childhood, including: (a) transcultural comparisons; (b) identification of high-risk sleep patterns for targeting early interventions, and (c) identification of novel, ultrasound-derived fetal brain markers of childhood sleep disturbances, NDDs and co-occurring interactions. |
| Collaborator Contribution | (1) Provision of data from the INTERGROWTH-21st and INTERBIO-21st datasets (2) Variance component analysis and SSD analysis |
| Impact | 1. Grant award from the Waterloo Foundation 2. 2 x publications submitted to Nature's special issue on Sleep in Health and Disease 3. 1 x publication in progress 4. Analysis for 4th publication underway |
| Start Year | 2024 |
| Description | Fetal brain maturation, infant feeding and neurodevelopment: Influences on sleep patterns of 2-year old children in geographically diverse populations |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | (1) Construction of the first prospective, international, standardised, infant sleep meta-dataset, representing 791 children from eight geographically and culturally diverse populations; (2) Description of the first transcultural sleep times, patterns and phenotypes during early childhood to guide risk estimation and clinical recommendations; (3) Improved understanding of the associations between sleep, environment and neurodevelopment during early childhood, including: (a) transcultural comparisons; (b) identification of high-risk sleep patterns for targeting early interventions, and (c) identification of novel, ultrasound-derived fetal brain markers of childhood sleep disturbances, NDDs and co-occurring interactions. |
| Collaborator Contribution | (1) Provision of data from the INTERGROWTH-21st and INTERBIO-21st datasets (2) Variance component analysis and SSD analysis |
| Impact | 1. Grant award from the Waterloo Foundation 2. 2 x publications submitted to Nature's special issue on Sleep in Health and Disease 3. 1 x publication in progress 4. Analysis for 4th publication underway |
| Start Year | 2024 |
| Description | FinnBrain Birth Cohort Study |
| Organisation | University of Oxford |
| Department | Nuffield Department of Obstetrics & Gynaecology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | 1) Training in team in INTER-NDA, and NeuroApp (2) Reliability assessments and standardisation (3) Assistance in data analysis and manuscript preparation. Funding Source: The Finnish Academy; Professional Status on Project: Collaborator |
| Collaborator Contribution | Overall design, funding, ethics, implementation and management of the study |
| Impact | Outcomes: i. Nolvi S, Tuulari JJ, Pelto J, Bridgett DJ, Eskola E, Lehtola SJ, Hashempou N, Korja R, Kataja E.-L, Saunavaara J, Parkkola R, Lähdesmäki T, Scheinin NM, Fernandes M, Karlsson L, Lewis JD, Fonov VS, Collins DL, & Karlsson, H. Neonatal amygdala Vols. and the development of self-regulation from early infancy to toddlerhood. Neuropsychology. 2021 35(3), 285-299. https://doi.org/10.1037/neu0000724 ii. Morales-Muñoz I, Nolvi S, Mäkelä T, Eskola E, Korja R, Fernandes M, Karlsson H, Paavonen EJ, Karlsson L. Sleep during infancy, inhibitory control and working memory in toddlers: findings from the FinnBrain cohort study. Sleep Science and Practice. 2021 Dec;5(1):1-5. |
| Start Year | 2015 |
| Description | FinnBrain Birth Cohort Study |
| Organisation | University of Turku |
| Department | Research Centre for Child Psychiatry |
| Country | Finland |
| Sector | Academic/University |
| PI Contribution | 1) Training in team in INTER-NDA, and NeuroApp (2) Reliability assessments and standardisation (3) Assistance in data analysis and manuscript preparation. Funding Source: The Finnish Academy; Professional Status on Project: Collaborator |
| Collaborator Contribution | Overall design, funding, ethics, implementation and management of the study |
| Impact | Outcomes: i. Nolvi S, Tuulari JJ, Pelto J, Bridgett DJ, Eskola E, Lehtola SJ, Hashempou N, Korja R, Kataja E.-L, Saunavaara J, Parkkola R, Lähdesmäki T, Scheinin NM, Fernandes M, Karlsson L, Lewis JD, Fonov VS, Collins DL, & Karlsson, H. Neonatal amygdala Vols. and the development of self-regulation from early infancy to toddlerhood. Neuropsychology. 2021 35(3), 285-299. https://doi.org/10.1037/neu0000724 ii. Morales-Muñoz I, Nolvi S, Mäkelä T, Eskola E, Korja R, Fernandes M, Karlsson H, Paavonen EJ, Karlsson L. Sleep during infancy, inhibitory control and working memory in toddlers: findings from the FinnBrain cohort study. Sleep Science and Practice. 2021 Dec;5(1):1-5. |
| Start Year | 2015 |
| Description | First UAE National-Representative Birth Cohort Study |
| Organisation | United Arab Emirates University |
| Country | United Arab Emirates |
| Sector | Academic/University |
| PI Contribution | Study design and application for initial funding, intellectual and implementation components relating to the measurement of neudevelopmental outcomes, training and standardization, data analysis and input into reports and publications, applications for additional funding |
| Collaborator Contribution | Study design and application for initial funding, measurement of health, growth and nutritional components relating to the cohort, ethics, recruitment and project implementation, data management and cleaning, initial analysis and report generation, applications for additional funding |
| Impact | Publications: 1. Mutare S, Feehan J, Cheikh Ismail L, Ali HI, Stojanovska L, Shehab A, Khair H, Ali R, Hwalla N, Kharroubi S, Hills AP. The first United Arab Emirates national representative birth cohort study: study protocol. Frontiers in Pediatrics. 2022 Apr 7;10:857034. 2. Mutare, Sharon, Maysm Mohamad, Jack Feehan, Leila Cheikh Ismail, Habiba Ali, Lily Stojanovska, Howaida Khair et al. "First Trimester Nutrition Insights from the United Arab Emirates Birth Cohort Study (UAE-BCS): Assessment of Dietary Intake, Micronutrient Profiles and Folic Acid Supplementation in Emirati Women." British Journal of Nutrition (2024). Research Grant: First UAE National-Representative Birth Cohort Study , UAE University (Co-PI, 2018-2026, Funder: UAE University, ~GBP 191,500) |
| Start Year | 2018 |
| Description | INTER-NEO Study |
| Organisation | University Hospital Southampton NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | 1. Project conceptualisation and design 2. Project protocols and all project documentation 3. Research governance: ethics and ethics amendments compilation and submission, responding to queries from ethics committee 4. Training and standardization of research team in the INTER-NDA 5. Compiling data analysis plan 6. Management of study implementation and supervision of research team 7. Communication with parents of participating children when necessary 8. Review of results and manuscripts |
| Collaborator Contribution | 1. Obtaining sponsor permission 2. Recruitment and data collection 3. Data curation and management 4. Data analysis 5. Drafting of reports and review of manuscripts, submission of manuscripts to scientific journals 6. Project presentations at conferences and internally |
| Impact | 1. NIHR ARC Wessex & Southampton Academy of Research (SOAR) - Research Initiation Internship Awards to R Lima with myself, Prof J Dorling and Dr M Johnson as supervisors 2. PhD Fellowship award to R Lima mentored by myself 3. Upcoming 2025 abstract submission to Neonatal Society spring meeting UK Multi-disciplinary collaboration: Neonatal medicine, neonatal neurology, paediatrics and child health, early brain science and early child development with cross-disciplinary woking between nursing and medical teams |
| Start Year | 2023 |
| Description | INTERGROWTH, INTERBIO and BRAINENDEVR (MRC award) integration analysis with Stanford University Prematurity Research Center |
| Organisation | Stanford University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | 1. Conceptual framework for analysis 2. Data overview, presentation and explanation of variables 3. Drafting concept note 4. Ideas for primary and secondary analyses --- Overview of work ---- Objective: To integrate various sources of maternal and newborn information (including both biological and phenotypical) to predict long-term newborn outcomes, focusing on neurocognitive, vision/auditory (EEG), sleep (actigraphy), growth and health outcomes at 2 years [1] Primary research question: Can a combination of detailed maternal characteristics, nutritional and medical conditions, genetic and metabolomic data throughout pregnancy, predict neurocognitive, vision, auditory, sleep, growth and health outcomes in newborns at 2 years? Secondary research questions: 1. How do specific maternal conditions like plasmogen deficiency, Phosphatidylcholine Imbalance, and Inflammatory Response influence newborn and early child neurodevelopment, growth and health? 2. How are pregnancy outcomes specifically PTB and SGA associated with 2-year neurocognitive, health and growth outcomes? 3. What is the impact of maternal metabolic and genetic factors, such as GWAS and EWAS profiles, on newborn neurocognitive, vision, sleep, auditory, health and growth outcomes? 4. Can fetal and neonatal nutritional deficits be linked to specific sleep, neurocognitive, growth and health patterns in newborns? |
| Collaborator Contribution | 1. Data science methodology overview and application of data science expertise to the conceptual framework developed by my team 2. Drafting data analysis plan which includes: i. Long Short-Term Memory (LSTM) neural network to predict long-term outcomes ii. High-dimensional correlation network across all variables iii. Interrogation of dataset to identify a biological signature for all measured phenotypical covariates and outcomes iv. Examine if a neural network predict newborn outcomes using actigraphy and EEG data v. Examine the generalizability/robustness of discovered biomarkers across different populations |
| Impact | None so far - this collaboration is in its initial stages |
| Start Year | 2023 |
| Description | INTERGROWTH, INTERBIO and BRAINENDEVR (MRC award) integration analysis with Stanford University Prematurity Research Center |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | 1. Conceptual framework for analysis 2. Data overview, presentation and explanation of variables 3. Drafting concept note 4. Ideas for primary and secondary analyses --- Overview of work ---- Objective: To integrate various sources of maternal and newborn information (including both biological and phenotypical) to predict long-term newborn outcomes, focusing on neurocognitive, vision/auditory (EEG), sleep (actigraphy), growth and health outcomes at 2 years [1] Primary research question: Can a combination of detailed maternal characteristics, nutritional and medical conditions, genetic and metabolomic data throughout pregnancy, predict neurocognitive, vision, auditory, sleep, growth and health outcomes in newborns at 2 years? Secondary research questions: 1. How do specific maternal conditions like plasmogen deficiency, Phosphatidylcholine Imbalance, and Inflammatory Response influence newborn and early child neurodevelopment, growth and health? 2. How are pregnancy outcomes specifically PTB and SGA associated with 2-year neurocognitive, health and growth outcomes? 3. What is the impact of maternal metabolic and genetic factors, such as GWAS and EWAS profiles, on newborn neurocognitive, vision, sleep, auditory, health and growth outcomes? 4. Can fetal and neonatal nutritional deficits be linked to specific sleep, neurocognitive, growth and health patterns in newborns? |
| Collaborator Contribution | 1. Data science methodology overview and application of data science expertise to the conceptual framework developed by my team 2. Drafting data analysis plan which includes: i. Long Short-Term Memory (LSTM) neural network to predict long-term outcomes ii. High-dimensional correlation network across all variables iii. Interrogation of dataset to identify a biological signature for all measured phenotypical covariates and outcomes iv. Examine if a neural network predict newborn outcomes using actigraphy and EEG data v. Examine the generalizability/robustness of discovered biomarkers across different populations |
| Impact | None so far - this collaboration is in its initial stages |
| Start Year | 2023 |
| Description | National Birth Cohort Study of Preterm Infants in the United Arab Emirates |
| Organisation | University of Sharjah |
| Country | United Arab Emirates |
| Sector | Academic/University |
| PI Contribution | Study protocol and design, initial and follow-on applications for funding, aspects relating to neurodevelopmental assessments including protocol design, training, implementation, analysis and report writing |
| Collaborator Contribution | Study protocol and design, initial and follow-on applications for funding, aspects relating to health, growth and nutritional assessments including protocol design, training, implementation, analysis and report writing, ethics, recruitment and follow-up, data collection, data management, team management, statistical analysis, first draft of reports |
| Impact | Research Grant: National Birth Cohort Study of Preterm Infants in the United Arab Emirates, University of Sharjah, UAE (Co-PI, 2022-2025, Funder: UAE University & University of Sharjah, ~GBP 94,677) |
| Start Year | 2022 |
| Description | Neurodevelopmental outcomes in children born during the COVID-19 pandemic in Gujarat, India |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Training in the OX-NDA and INTER-NDA Statistical and intellectual contributions to data analysis plan and report writing |
| Collaborator Contribution | Research design, methodology and implementation |
| Impact | New collaborations - no outputs yet |
| Start Year | 2022 |
| Description | The EveryPrem Project: Standardized neurodevelopmental screening for children born preterm |
| Organisation | John Radcliffe Hospital |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | I am a co-PI of this Project. My key contributions so far have been: 1) Project conceptualisation, design and drafting of first project protocol 2) Compilation of ethics application 3) Compilation of the first draft of patient forms, participant invitation letters, participant follow-up documents and data collection forms 4) Training of the research assistants in the neurodevelopment assessment 5) Providing data into the costing of the INTER-NDA 6) Application to an NIHR RfPB grant for this project (this was rejected in Nov 2018) My further input will be: 1) Ongoing oversight of the project implementation, particularly in aspects pertaining to the neurodevelopment assessment 2) Data management including database creation 3) Data analysis 4) Manuscript preparation and submission for publication |
| Collaborator Contribution | My co-PI (Dr Frances O'Brien) and my CI (Professor S. Kennedy) have made the following contributions to this partnership: 1) Securing of internal university funding to cover RA costs and participant travel expenses 2) Reviewing of all study documents, including the project protocol 3) Attending the ethics interview (Professor Kennedy) 4) Participant contact and recruitment (Dr O'Brien) 5) Liaising with the Trust for the necessary approvals (Prof. Kennedy and Dr O'Brien) They will also be providing further input into: 1) Costing of the BSID-III 2) Ongoing oversight of the project implementation, particularly in aspects pertaining to the neurodevelopment assessment 3) Data management including database creation 4) Data analysis 5) Manuscript preparation and submission for publication 6) Urgent referral of participants with serious delay to a paediatrician |
| Impact | Outcomes/Outputs at present: 1) Ethics approval 2) Securing of university funding 3) Training of research team 4) Participant recruitment Expected outcomes in the next 12 months: 1) 100 neurodevelopment assessments of children born preterm 2) Fist phase of data analysis 3) Costing analysis for novel neurodevelopment test vs standard of care The collaboration is multi-disciplinary and includes collaborations with paediatricians (myself), neonatologists (Dr O'Brien), obstetricians and gynaecologists (Professor S Kennedy) and the department of health economics at the University of Oxford.The disciplines involved are: 1) Paediatrics, including neonatology 2) O&G 3) Health Economics |
| Start Year | 2019 |
| Description | The EveryPrem Project: Standardized neurodevelopmental screening for children born preterm |
| Organisation | University of Oxford |
| Department | Nuffield Department of Obstetrics & Gynaecology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I am a co-PI of this Project. My key contributions so far have been: 1) Project conceptualisation, design and drafting of first project protocol 2) Compilation of ethics application 3) Compilation of the first draft of patient forms, participant invitation letters, participant follow-up documents and data collection forms 4) Training of the research assistants in the neurodevelopment assessment 5) Providing data into the costing of the INTER-NDA 6) Application to an NIHR RfPB grant for this project (this was rejected in Nov 2018) My further input will be: 1) Ongoing oversight of the project implementation, particularly in aspects pertaining to the neurodevelopment assessment 2) Data management including database creation 3) Data analysis 4) Manuscript preparation and submission for publication |
| Collaborator Contribution | My co-PI (Dr Frances O'Brien) and my CI (Professor S. Kennedy) have made the following contributions to this partnership: 1) Securing of internal university funding to cover RA costs and participant travel expenses 2) Reviewing of all study documents, including the project protocol 3) Attending the ethics interview (Professor Kennedy) 4) Participant contact and recruitment (Dr O'Brien) 5) Liaising with the Trust for the necessary approvals (Prof. Kennedy and Dr O'Brien) They will also be providing further input into: 1) Costing of the BSID-III 2) Ongoing oversight of the project implementation, particularly in aspects pertaining to the neurodevelopment assessment 3) Data management including database creation 4) Data analysis 5) Manuscript preparation and submission for publication 6) Urgent referral of participants with serious delay to a paediatrician |
| Impact | Outcomes/Outputs at present: 1) Ethics approval 2) Securing of university funding 3) Training of research team 4) Participant recruitment Expected outcomes in the next 12 months: 1) 100 neurodevelopment assessments of children born preterm 2) Fist phase of data analysis 3) Costing analysis for novel neurodevelopment test vs standard of care The collaboration is multi-disciplinary and includes collaborations with paediatricians (myself), neonatologists (Dr O'Brien), obstetricians and gynaecologists (Professor S Kennedy) and the department of health economics at the University of Oxford.The disciplines involved are: 1) Paediatrics, including neonatology 2) O&G 3) Health Economics |
| Start Year | 2019 |
| Description | The INTERBIO-21st Study |
| Organisation | Aga Khan Hospital |
| Country | Kenya |
| Sector | Hospitals |
| PI Contribution | Neurodevelopment Lead for Project, training of site teams in the INTERGROWTH-21st Neurodevelopment Package, reliability testing and standardisation, implementation of Package at 8 project sites, QC, data analysis, manuscript preparation and publication, presentation of results. Funding Source: The Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator |
| Collaborator Contribution | Overall study design, funding, ethics and implementation of fetal (ultrasound), anthropometric and nutritional, and biosample collection aspects of the study. Data analysis and manuscript preparation. Development and maintenance of biobank. |
| Impact | Outputs: (i) establishment a biobank (INTERBIO-Bank) of maternal blood, maternal faeces and cord blood/placental samples from healthy and complicated pregnancies to allow nutritional, epigenetic and other biomarker studies to be performed (ii) Villar J, Ochieng R, Gunier RB, Papageorghiou AT, Rauch S, McGready R, Gauglitz JM, Barros FC, Vatish M, Fernandes M, Zammit V. Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity: prospective observational multinational INTERBIO-21st fetal study. The Lancet Diabetes & Endocrinology. 2022 Oct 1;10(10):710-9. (iii) Papageorghiou AT, Restrepo-Me´ndez MC, McGready R, Barros FC, Nosten F, Munim S, Ochieng R, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Winsey A, Uauy R, Bhutta ZA, Kennedy SH, Villar J. Aetiologically-Based Small for Gestational Age Phenotypes Have Differential Morbidity, Growth and Neurodevelopment at Age 2: The INTERBIO-21st Newborn Study. Lancet Child Adolesc Health. 28 March 2022. http://dx.doi.org/10.2139/ssrn.4068252. (iv) Villar J, Restrepo-Méndez M-C, McGready R, Barros FC, Victora CG, Munim S, Papageorghiou AT, Ochieng, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Zondervan KT, Winsey A, Nosten F, Uauy R, Bhutta ZA, and Kennedy SH. Preterm birth phenotypes have differential morbidity, growth and neurodevelopment at age 2: the INTERBIO-21st Newborn Study.JAMA Peds 2021 Mar 1;e206087. doi: 10.1001/jamapediatrics.2020.6087 (v) Kennedy SH, Victora CG, Craik R, Ash S, Barros FC, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Ismail LC, Lambert A. Deep clinical and biological phenotyping of the preterm birth and small for gestational age syndromes: The INTERBIO-21 st Newborn Case-Control Study protocol. Gates open research. 2018;2. (vi) Villar J, Restrepo-Méndez MC, McGready R, Fernandes M Bhutta ZA and Kennedy SH. Association Between Preterm-Birth Phenotypes and Differential Morbidity, Growth, and Neurodevelopment at Age 2 Years: Results From the INTERBIO-21st Newborn Study. JAMA Pediatrics. March 2021. doi:10.1001/jamapediatrics.2020.6087 (vii) Villar J, Gunier RB, Tshivuila-Matala CO, Rauch SA, Nosten F, Ochieng R, Restrepo-Méndez MC, McGready R, Barros FC, Fernandes M, Carrara VI. Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study. Nature Medicine. 2021 Mar 18:1-6. (viii) Ohuma EO, Jabin J, Young MF Fernandes M Kennedy SH and Villar J. Association between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study. The Lancet Haematology (2023),https://doi.org/10.1016/S2352-3026(23)00170-9. |
| Start Year | 2014 |
| Description | The INTERBIO-21st Study |
| Organisation | Aga Khan University Hospital |
| Country | Pakistan |
| Sector | Hospitals |
| PI Contribution | Neurodevelopment Lead for Project, training of site teams in the INTERGROWTH-21st Neurodevelopment Package, reliability testing and standardisation, implementation of Package at 8 project sites, QC, data analysis, manuscript preparation and publication, presentation of results. Funding Source: The Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator |
| Collaborator Contribution | Overall study design, funding, ethics and implementation of fetal (ultrasound), anthropometric and nutritional, and biosample collection aspects of the study. Data analysis and manuscript preparation. Development and maintenance of biobank. |
| Impact | Outputs: (i) establishment a biobank (INTERBIO-Bank) of maternal blood, maternal faeces and cord blood/placental samples from healthy and complicated pregnancies to allow nutritional, epigenetic and other biomarker studies to be performed (ii) Villar J, Ochieng R, Gunier RB, Papageorghiou AT, Rauch S, McGready R, Gauglitz JM, Barros FC, Vatish M, Fernandes M, Zammit V. Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity: prospective observational multinational INTERBIO-21st fetal study. The Lancet Diabetes & Endocrinology. 2022 Oct 1;10(10):710-9. (iii) Papageorghiou AT, Restrepo-Me´ndez MC, McGready R, Barros FC, Nosten F, Munim S, Ochieng R, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Winsey A, Uauy R, Bhutta ZA, Kennedy SH, Villar J. Aetiologically-Based Small for Gestational Age Phenotypes Have Differential Morbidity, Growth and Neurodevelopment at Age 2: The INTERBIO-21st Newborn Study. Lancet Child Adolesc Health. 28 March 2022. http://dx.doi.org/10.2139/ssrn.4068252. (iv) Villar J, Restrepo-Méndez M-C, McGready R, Barros FC, Victora CG, Munim S, Papageorghiou AT, Ochieng, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Zondervan KT, Winsey A, Nosten F, Uauy R, Bhutta ZA, and Kennedy SH. Preterm birth phenotypes have differential morbidity, growth and neurodevelopment at age 2: the INTERBIO-21st Newborn Study.JAMA Peds 2021 Mar 1;e206087. doi: 10.1001/jamapediatrics.2020.6087 (v) Kennedy SH, Victora CG, Craik R, Ash S, Barros FC, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Ismail LC, Lambert A. Deep clinical and biological phenotyping of the preterm birth and small for gestational age syndromes: The INTERBIO-21 st Newborn Case-Control Study protocol. Gates open research. 2018;2. (vi) Villar J, Restrepo-Méndez MC, McGready R, Fernandes M Bhutta ZA and Kennedy SH. Association Between Preterm-Birth Phenotypes and Differential Morbidity, Growth, and Neurodevelopment at Age 2 Years: Results From the INTERBIO-21st Newborn Study. JAMA Pediatrics. March 2021. doi:10.1001/jamapediatrics.2020.6087 (vii) Villar J, Gunier RB, Tshivuila-Matala CO, Rauch SA, Nosten F, Ochieng R, Restrepo-Méndez MC, McGready R, Barros FC, Fernandes M, Carrara VI. Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study. Nature Medicine. 2021 Mar 18:1-6. (viii) Ohuma EO, Jabin J, Young MF Fernandes M Kennedy SH and Villar J. Association between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study. The Lancet Haematology (2023),https://doi.org/10.1016/S2352-3026(23)00170-9. |
| Start Year | 2014 |
| Description | The INTERBIO-21st Study |
| Organisation | Beijing Obstetrics and Gynecology Hospital |
| Country | China |
| Sector | Hospitals |
| PI Contribution | Neurodevelopment Lead for Project, training of site teams in the INTERGROWTH-21st Neurodevelopment Package, reliability testing and standardisation, implementation of Package at 8 project sites, QC, data analysis, manuscript preparation and publication, presentation of results. Funding Source: The Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator |
| Collaborator Contribution | Overall study design, funding, ethics and implementation of fetal (ultrasound), anthropometric and nutritional, and biosample collection aspects of the study. Data analysis and manuscript preparation. Development and maintenance of biobank. |
| Impact | Outputs: (i) establishment a biobank (INTERBIO-Bank) of maternal blood, maternal faeces and cord blood/placental samples from healthy and complicated pregnancies to allow nutritional, epigenetic and other biomarker studies to be performed (ii) Villar J, Ochieng R, Gunier RB, Papageorghiou AT, Rauch S, McGready R, Gauglitz JM, Barros FC, Vatish M, Fernandes M, Zammit V. Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity: prospective observational multinational INTERBIO-21st fetal study. The Lancet Diabetes & Endocrinology. 2022 Oct 1;10(10):710-9. (iii) Papageorghiou AT, Restrepo-Me´ndez MC, McGready R, Barros FC, Nosten F, Munim S, Ochieng R, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Winsey A, Uauy R, Bhutta ZA, Kennedy SH, Villar J. Aetiologically-Based Small for Gestational Age Phenotypes Have Differential Morbidity, Growth and Neurodevelopment at Age 2: The INTERBIO-21st Newborn Study. Lancet Child Adolesc Health. 28 March 2022. http://dx.doi.org/10.2139/ssrn.4068252. (iv) Villar J, Restrepo-Méndez M-C, McGready R, Barros FC, Victora CG, Munim S, Papageorghiou AT, Ochieng, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Zondervan KT, Winsey A, Nosten F, Uauy R, Bhutta ZA, and Kennedy SH. Preterm birth phenotypes have differential morbidity, growth and neurodevelopment at age 2: the INTERBIO-21st Newborn Study.JAMA Peds 2021 Mar 1;e206087. doi: 10.1001/jamapediatrics.2020.6087 (v) Kennedy SH, Victora CG, Craik R, Ash S, Barros FC, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Ismail LC, Lambert A. Deep clinical and biological phenotyping of the preterm birth and small for gestational age syndromes: The INTERBIO-21 st Newborn Case-Control Study protocol. Gates open research. 2018;2. (vi) Villar J, Restrepo-Méndez MC, McGready R, Fernandes M Bhutta ZA and Kennedy SH. Association Between Preterm-Birth Phenotypes and Differential Morbidity, Growth, and Neurodevelopment at Age 2 Years: Results From the INTERBIO-21st Newborn Study. JAMA Pediatrics. March 2021. doi:10.1001/jamapediatrics.2020.6087 (vii) Villar J, Gunier RB, Tshivuila-Matala CO, Rauch SA, Nosten F, Ochieng R, Restrepo-Méndez MC, McGready R, Barros FC, Fernandes M, Carrara VI. Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study. Nature Medicine. 2021 Mar 18:1-6. (viii) Ohuma EO, Jabin J, Young MF Fernandes M Kennedy SH and Villar J. Association between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study. The Lancet Haematology (2023),https://doi.org/10.1016/S2352-3026(23)00170-9. |
| Start Year | 2014 |
| Description | The INTERBIO-21st Study |
| Organisation | Chris Hani Baragwanath Hospital |
| Country | South Africa |
| Sector | Hospitals |
| PI Contribution | Neurodevelopment Lead for Project, training of site teams in the INTERGROWTH-21st Neurodevelopment Package, reliability testing and standardisation, implementation of Package at 8 project sites, QC, data analysis, manuscript preparation and publication, presentation of results. Funding Source: The Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator |
| Collaborator Contribution | Overall study design, funding, ethics and implementation of fetal (ultrasound), anthropometric and nutritional, and biosample collection aspects of the study. Data analysis and manuscript preparation. Development and maintenance of biobank. |
| Impact | Outputs: (i) establishment a biobank (INTERBIO-Bank) of maternal blood, maternal faeces and cord blood/placental samples from healthy and complicated pregnancies to allow nutritional, epigenetic and other biomarker studies to be performed (ii) Villar J, Ochieng R, Gunier RB, Papageorghiou AT, Rauch S, McGready R, Gauglitz JM, Barros FC, Vatish M, Fernandes M, Zammit V. Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity: prospective observational multinational INTERBIO-21st fetal study. The Lancet Diabetes & Endocrinology. 2022 Oct 1;10(10):710-9. (iii) Papageorghiou AT, Restrepo-Me´ndez MC, McGready R, Barros FC, Nosten F, Munim S, Ochieng R, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Winsey A, Uauy R, Bhutta ZA, Kennedy SH, Villar J. Aetiologically-Based Small for Gestational Age Phenotypes Have Differential Morbidity, Growth and Neurodevelopment at Age 2: The INTERBIO-21st Newborn Study. Lancet Child Adolesc Health. 28 March 2022. http://dx.doi.org/10.2139/ssrn.4068252. (iv) Villar J, Restrepo-Méndez M-C, McGready R, Barros FC, Victora CG, Munim S, Papageorghiou AT, Ochieng, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Zondervan KT, Winsey A, Nosten F, Uauy R, Bhutta ZA, and Kennedy SH. Preterm birth phenotypes have differential morbidity, growth and neurodevelopment at age 2: the INTERBIO-21st Newborn Study.JAMA Peds 2021 Mar 1;e206087. doi: 10.1001/jamapediatrics.2020.6087 (v) Kennedy SH, Victora CG, Craik R, Ash S, Barros FC, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Ismail LC, Lambert A. Deep clinical and biological phenotyping of the preterm birth and small for gestational age syndromes: The INTERBIO-21 st Newborn Case-Control Study protocol. Gates open research. 2018;2. (vi) Villar J, Restrepo-Méndez MC, McGready R, Fernandes M Bhutta ZA and Kennedy SH. Association Between Preterm-Birth Phenotypes and Differential Morbidity, Growth, and Neurodevelopment at Age 2 Years: Results From the INTERBIO-21st Newborn Study. JAMA Pediatrics. March 2021. doi:10.1001/jamapediatrics.2020.6087 (vii) Villar J, Gunier RB, Tshivuila-Matala CO, Rauch SA, Nosten F, Ochieng R, Restrepo-Méndez MC, McGready R, Barros FC, Fernandes M, Carrara VI. Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study. Nature Medicine. 2021 Mar 18:1-6. (viii) Ohuma EO, Jabin J, Young MF Fernandes M Kennedy SH and Villar J. Association between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study. The Lancet Haematology (2023),https://doi.org/10.1016/S2352-3026(23)00170-9. |
| Start Year | 2014 |
| Description | The INTERBIO-21st Study |
| Organisation | Federal University of Pelotas (UFPel) |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | Neurodevelopment Lead for Project, training of site teams in the INTERGROWTH-21st Neurodevelopment Package, reliability testing and standardisation, implementation of Package at 8 project sites, QC, data analysis, manuscript preparation and publication, presentation of results. Funding Source: The Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator |
| Collaborator Contribution | Overall study design, funding, ethics and implementation of fetal (ultrasound), anthropometric and nutritional, and biosample collection aspects of the study. Data analysis and manuscript preparation. Development and maintenance of biobank. |
| Impact | Outputs: (i) establishment a biobank (INTERBIO-Bank) of maternal blood, maternal faeces and cord blood/placental samples from healthy and complicated pregnancies to allow nutritional, epigenetic and other biomarker studies to be performed (ii) Villar J, Ochieng R, Gunier RB, Papageorghiou AT, Rauch S, McGready R, Gauglitz JM, Barros FC, Vatish M, Fernandes M, Zammit V. Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity: prospective observational multinational INTERBIO-21st fetal study. The Lancet Diabetes & Endocrinology. 2022 Oct 1;10(10):710-9. (iii) Papageorghiou AT, Restrepo-Me´ndez MC, McGready R, Barros FC, Nosten F, Munim S, Ochieng R, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Winsey A, Uauy R, Bhutta ZA, Kennedy SH, Villar J. Aetiologically-Based Small for Gestational Age Phenotypes Have Differential Morbidity, Growth and Neurodevelopment at Age 2: The INTERBIO-21st Newborn Study. Lancet Child Adolesc Health. 28 March 2022. http://dx.doi.org/10.2139/ssrn.4068252. (iv) Villar J, Restrepo-Méndez M-C, McGready R, Barros FC, Victora CG, Munim S, Papageorghiou AT, Ochieng, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Zondervan KT, Winsey A, Nosten F, Uauy R, Bhutta ZA, and Kennedy SH. Preterm birth phenotypes have differential morbidity, growth and neurodevelopment at age 2: the INTERBIO-21st Newborn Study.JAMA Peds 2021 Mar 1;e206087. doi: 10.1001/jamapediatrics.2020.6087 (v) Kennedy SH, Victora CG, Craik R, Ash S, Barros FC, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Ismail LC, Lambert A. Deep clinical and biological phenotyping of the preterm birth and small for gestational age syndromes: The INTERBIO-21 st Newborn Case-Control Study protocol. Gates open research. 2018;2. (vi) Villar J, Restrepo-Méndez MC, McGready R, Fernandes M Bhutta ZA and Kennedy SH. Association Between Preterm-Birth Phenotypes and Differential Morbidity, Growth, and Neurodevelopment at Age 2 Years: Results From the INTERBIO-21st Newborn Study. JAMA Pediatrics. March 2021. doi:10.1001/jamapediatrics.2020.6087 (vii) Villar J, Gunier RB, Tshivuila-Matala CO, Rauch SA, Nosten F, Ochieng R, Restrepo-Méndez MC, McGready R, Barros FC, Fernandes M, Carrara VI. Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study. Nature Medicine. 2021 Mar 18:1-6. (viii) Ohuma EO, Jabin J, Young MF Fernandes M Kennedy SH and Villar J. Association between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study. The Lancet Haematology (2023),https://doi.org/10.1016/S2352-3026(23)00170-9. |
| Start Year | 2014 |
| Description | The INTERBIO-21st Study |
| Organisation | Global Alliance to Prevent Prematurity and Stillbirth |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | Neurodevelopment Lead for Project, training of site teams in the INTERGROWTH-21st Neurodevelopment Package, reliability testing and standardisation, implementation of Package at 8 project sites, QC, data analysis, manuscript preparation and publication, presentation of results. Funding Source: The Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator |
| Collaborator Contribution | Overall study design, funding, ethics and implementation of fetal (ultrasound), anthropometric and nutritional, and biosample collection aspects of the study. Data analysis and manuscript preparation. Development and maintenance of biobank. |
| Impact | Outputs: (i) establishment a biobank (INTERBIO-Bank) of maternal blood, maternal faeces and cord blood/placental samples from healthy and complicated pregnancies to allow nutritional, epigenetic and other biomarker studies to be performed (ii) Villar J, Ochieng R, Gunier RB, Papageorghiou AT, Rauch S, McGready R, Gauglitz JM, Barros FC, Vatish M, Fernandes M, Zammit V. Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity: prospective observational multinational INTERBIO-21st fetal study. The Lancet Diabetes & Endocrinology. 2022 Oct 1;10(10):710-9. (iii) Papageorghiou AT, Restrepo-Me´ndez MC, McGready R, Barros FC, Nosten F, Munim S, Ochieng R, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Winsey A, Uauy R, Bhutta ZA, Kennedy SH, Villar J. Aetiologically-Based Small for Gestational Age Phenotypes Have Differential Morbidity, Growth and Neurodevelopment at Age 2: The INTERBIO-21st Newborn Study. Lancet Child Adolesc Health. 28 March 2022. http://dx.doi.org/10.2139/ssrn.4068252. (iv) Villar J, Restrepo-Méndez M-C, McGready R, Barros FC, Victora CG, Munim S, Papageorghiou AT, Ochieng, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Zondervan KT, Winsey A, Nosten F, Uauy R, Bhutta ZA, and Kennedy SH. Preterm birth phenotypes have differential morbidity, growth and neurodevelopment at age 2: the INTERBIO-21st Newborn Study.JAMA Peds 2021 Mar 1;e206087. doi: 10.1001/jamapediatrics.2020.6087 (v) Kennedy SH, Victora CG, Craik R, Ash S, Barros FC, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Ismail LC, Lambert A. Deep clinical and biological phenotyping of the preterm birth and small for gestational age syndromes: The INTERBIO-21 st Newborn Case-Control Study protocol. Gates open research. 2018;2. (vi) Villar J, Restrepo-Méndez MC, McGready R, Fernandes M Bhutta ZA and Kennedy SH. Association Between Preterm-Birth Phenotypes and Differential Morbidity, Growth, and Neurodevelopment at Age 2 Years: Results From the INTERBIO-21st Newborn Study. JAMA Pediatrics. March 2021. doi:10.1001/jamapediatrics.2020.6087 (vii) Villar J, Gunier RB, Tshivuila-Matala CO, Rauch SA, Nosten F, Ochieng R, Restrepo-Méndez MC, McGready R, Barros FC, Fernandes M, Carrara VI. Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study. Nature Medicine. 2021 Mar 18:1-6. (viii) Ohuma EO, Jabin J, Young MF Fernandes M Kennedy SH and Villar J. Association between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study. The Lancet Haematology (2023),https://doi.org/10.1016/S2352-3026(23)00170-9. |
| Start Year | 2014 |
| Description | The INTERBIO-21st Study |
| Organisation | International Atomic Energy Agency |
| Department | Division of Human Health |
| Country | Austria |
| Sector | Public |
| PI Contribution | Neurodevelopment Lead for Project, training of site teams in the INTERGROWTH-21st Neurodevelopment Package, reliability testing and standardisation, implementation of Package at 8 project sites, QC, data analysis, manuscript preparation and publication, presentation of results. Funding Source: The Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator |
| Collaborator Contribution | Overall study design, funding, ethics and implementation of fetal (ultrasound), anthropometric and nutritional, and biosample collection aspects of the study. Data analysis and manuscript preparation. Development and maintenance of biobank. |
| Impact | Outputs: (i) establishment a biobank (INTERBIO-Bank) of maternal blood, maternal faeces and cord blood/placental samples from healthy and complicated pregnancies to allow nutritional, epigenetic and other biomarker studies to be performed (ii) Villar J, Ochieng R, Gunier RB, Papageorghiou AT, Rauch S, McGready R, Gauglitz JM, Barros FC, Vatish M, Fernandes M, Zammit V. Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity: prospective observational multinational INTERBIO-21st fetal study. The Lancet Diabetes & Endocrinology. 2022 Oct 1;10(10):710-9. (iii) Papageorghiou AT, Restrepo-Me´ndez MC, McGready R, Barros FC, Nosten F, Munim S, Ochieng R, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Winsey A, Uauy R, Bhutta ZA, Kennedy SH, Villar J. Aetiologically-Based Small for Gestational Age Phenotypes Have Differential Morbidity, Growth and Neurodevelopment at Age 2: The INTERBIO-21st Newborn Study. Lancet Child Adolesc Health. 28 March 2022. http://dx.doi.org/10.2139/ssrn.4068252. (iv) Villar J, Restrepo-Méndez M-C, McGready R, Barros FC, Victora CG, Munim S, Papageorghiou AT, Ochieng, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Zondervan KT, Winsey A, Nosten F, Uauy R, Bhutta ZA, and Kennedy SH. Preterm birth phenotypes have differential morbidity, growth and neurodevelopment at age 2: the INTERBIO-21st Newborn Study.JAMA Peds 2021 Mar 1;e206087. doi: 10.1001/jamapediatrics.2020.6087 (v) Kennedy SH, Victora CG, Craik R, Ash S, Barros FC, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Ismail LC, Lambert A. Deep clinical and biological phenotyping of the preterm birth and small for gestational age syndromes: The INTERBIO-21 st Newborn Case-Control Study protocol. Gates open research. 2018;2. (vi) Villar J, Restrepo-Méndez MC, McGready R, Fernandes M Bhutta ZA and Kennedy SH. Association Between Preterm-Birth Phenotypes and Differential Morbidity, Growth, and Neurodevelopment at Age 2 Years: Results From the INTERBIO-21st Newborn Study. JAMA Pediatrics. March 2021. doi:10.1001/jamapediatrics.2020.6087 (vii) Villar J, Gunier RB, Tshivuila-Matala CO, Rauch SA, Nosten F, Ochieng R, Restrepo-Méndez MC, McGready R, Barros FC, Fernandes M, Carrara VI. Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study. Nature Medicine. 2021 Mar 18:1-6. (viii) Ohuma EO, Jabin J, Young MF Fernandes M Kennedy SH and Villar J. Association between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study. The Lancet Haematology (2023),https://doi.org/10.1016/S2352-3026(23)00170-9. |
| Start Year | 2014 |
| Description | The INTERBIO-21st Study |
| Organisation | Kenyan Institute for Medical Research (KEMRI) |
| Country | Kenya |
| Sector | Public |
| PI Contribution | Neurodevelopment Lead for Project, training of site teams in the INTERGROWTH-21st Neurodevelopment Package, reliability testing and standardisation, implementation of Package at 8 project sites, QC, data analysis, manuscript preparation and publication, presentation of results. Funding Source: The Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator |
| Collaborator Contribution | Overall study design, funding, ethics and implementation of fetal (ultrasound), anthropometric and nutritional, and biosample collection aspects of the study. Data analysis and manuscript preparation. Development and maintenance of biobank. |
| Impact | Outputs: (i) establishment a biobank (INTERBIO-Bank) of maternal blood, maternal faeces and cord blood/placental samples from healthy and complicated pregnancies to allow nutritional, epigenetic and other biomarker studies to be performed (ii) Villar J, Ochieng R, Gunier RB, Papageorghiou AT, Rauch S, McGready R, Gauglitz JM, Barros FC, Vatish M, Fernandes M, Zammit V. Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity: prospective observational multinational INTERBIO-21st fetal study. The Lancet Diabetes & Endocrinology. 2022 Oct 1;10(10):710-9. (iii) Papageorghiou AT, Restrepo-Me´ndez MC, McGready R, Barros FC, Nosten F, Munim S, Ochieng R, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Winsey A, Uauy R, Bhutta ZA, Kennedy SH, Villar J. Aetiologically-Based Small for Gestational Age Phenotypes Have Differential Morbidity, Growth and Neurodevelopment at Age 2: The INTERBIO-21st Newborn Study. Lancet Child Adolesc Health. 28 March 2022. http://dx.doi.org/10.2139/ssrn.4068252. (iv) Villar J, Restrepo-Méndez M-C, McGready R, Barros FC, Victora CG, Munim S, Papageorghiou AT, Ochieng, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Zondervan KT, Winsey A, Nosten F, Uauy R, Bhutta ZA, and Kennedy SH. Preterm birth phenotypes have differential morbidity, growth and neurodevelopment at age 2: the INTERBIO-21st Newborn Study.JAMA Peds 2021 Mar 1;e206087. doi: 10.1001/jamapediatrics.2020.6087 (v) Kennedy SH, Victora CG, Craik R, Ash S, Barros FC, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Ismail LC, Lambert A. Deep clinical and biological phenotyping of the preterm birth and small for gestational age syndromes: The INTERBIO-21 st Newborn Case-Control Study protocol. Gates open research. 2018;2. (vi) Villar J, Restrepo-Méndez MC, McGready R, Fernandes M Bhutta ZA and Kennedy SH. Association Between Preterm-Birth Phenotypes and Differential Morbidity, Growth, and Neurodevelopment at Age 2 Years: Results From the INTERBIO-21st Newborn Study. JAMA Pediatrics. March 2021. doi:10.1001/jamapediatrics.2020.6087 (vii) Villar J, Gunier RB, Tshivuila-Matala CO, Rauch SA, Nosten F, Ochieng R, Restrepo-Méndez MC, McGready R, Barros FC, Fernandes M, Carrara VI. Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study. Nature Medicine. 2021 Mar 18:1-6. (viii) Ohuma EO, Jabin J, Young MF Fernandes M Kennedy SH and Villar J. Association between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study. The Lancet Haematology (2023),https://doi.org/10.1016/S2352-3026(23)00170-9. |
| Start Year | 2014 |
| Description | The INTERBIO-21st Study |
| Organisation | Ketkar Hospital |
| Country | India |
| Sector | Hospitals |
| PI Contribution | Neurodevelopment Lead for Project, training of site teams in the INTERGROWTH-21st Neurodevelopment Package, reliability testing and standardisation, implementation of Package at 8 project sites, QC, data analysis, manuscript preparation and publication, presentation of results. Funding Source: The Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator |
| Collaborator Contribution | Overall study design, funding, ethics and implementation of fetal (ultrasound), anthropometric and nutritional, and biosample collection aspects of the study. Data analysis and manuscript preparation. Development and maintenance of biobank. |
| Impact | Outputs: (i) establishment a biobank (INTERBIO-Bank) of maternal blood, maternal faeces and cord blood/placental samples from healthy and complicated pregnancies to allow nutritional, epigenetic and other biomarker studies to be performed (ii) Villar J, Ochieng R, Gunier RB, Papageorghiou AT, Rauch S, McGready R, Gauglitz JM, Barros FC, Vatish M, Fernandes M, Zammit V. Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity: prospective observational multinational INTERBIO-21st fetal study. The Lancet Diabetes & Endocrinology. 2022 Oct 1;10(10):710-9. (iii) Papageorghiou AT, Restrepo-Me´ndez MC, McGready R, Barros FC, Nosten F, Munim S, Ochieng R, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Winsey A, Uauy R, Bhutta ZA, Kennedy SH, Villar J. Aetiologically-Based Small for Gestational Age Phenotypes Have Differential Morbidity, Growth and Neurodevelopment at Age 2: The INTERBIO-21st Newborn Study. Lancet Child Adolesc Health. 28 March 2022. http://dx.doi.org/10.2139/ssrn.4068252. (iv) Villar J, Restrepo-Méndez M-C, McGready R, Barros FC, Victora CG, Munim S, Papageorghiou AT, Ochieng, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Zondervan KT, Winsey A, Nosten F, Uauy R, Bhutta ZA, and Kennedy SH. Preterm birth phenotypes have differential morbidity, growth and neurodevelopment at age 2: the INTERBIO-21st Newborn Study.JAMA Peds 2021 Mar 1;e206087. doi: 10.1001/jamapediatrics.2020.6087 (v) Kennedy SH, Victora CG, Craik R, Ash S, Barros FC, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Ismail LC, Lambert A. Deep clinical and biological phenotyping of the preterm birth and small for gestational age syndromes: The INTERBIO-21 st Newborn Case-Control Study protocol. Gates open research. 2018;2. (vi) Villar J, Restrepo-Méndez MC, McGready R, Fernandes M Bhutta ZA and Kennedy SH. Association Between Preterm-Birth Phenotypes and Differential Morbidity, Growth, and Neurodevelopment at Age 2 Years: Results From the INTERBIO-21st Newborn Study. JAMA Pediatrics. March 2021. doi:10.1001/jamapediatrics.2020.6087 (vii) Villar J, Gunier RB, Tshivuila-Matala CO, Rauch SA, Nosten F, Ochieng R, Restrepo-Méndez MC, McGready R, Barros FC, Fernandes M, Carrara VI. Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study. Nature Medicine. 2021 Mar 18:1-6. (viii) Ohuma EO, Jabin J, Young MF Fernandes M Kennedy SH and Villar J. Association between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study. The Lancet Haematology (2023),https://doi.org/10.1016/S2352-3026(23)00170-9. |
| Start Year | 2014 |
| Description | The INTERBIO-21st Study |
| Organisation | Mahidol University |
| Department | Faculty of Tropical Medicine |
| Country | Thailand |
| Sector | Academic/University |
| PI Contribution | Neurodevelopment Lead for Project, training of site teams in the INTERGROWTH-21st Neurodevelopment Package, reliability testing and standardisation, implementation of Package at 8 project sites, QC, data analysis, manuscript preparation and publication, presentation of results. Funding Source: The Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator |
| Collaborator Contribution | Overall study design, funding, ethics and implementation of fetal (ultrasound), anthropometric and nutritional, and biosample collection aspects of the study. Data analysis and manuscript preparation. Development and maintenance of biobank. |
| Impact | Outputs: (i) establishment a biobank (INTERBIO-Bank) of maternal blood, maternal faeces and cord blood/placental samples from healthy and complicated pregnancies to allow nutritional, epigenetic and other biomarker studies to be performed (ii) Villar J, Ochieng R, Gunier RB, Papageorghiou AT, Rauch S, McGready R, Gauglitz JM, Barros FC, Vatish M, Fernandes M, Zammit V. Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity: prospective observational multinational INTERBIO-21st fetal study. The Lancet Diabetes & Endocrinology. 2022 Oct 1;10(10):710-9. (iii) Papageorghiou AT, Restrepo-Me´ndez MC, McGready R, Barros FC, Nosten F, Munim S, Ochieng R, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Winsey A, Uauy R, Bhutta ZA, Kennedy SH, Villar J. Aetiologically-Based Small for Gestational Age Phenotypes Have Differential Morbidity, Growth and Neurodevelopment at Age 2: The INTERBIO-21st Newborn Study. Lancet Child Adolesc Health. 28 March 2022. http://dx.doi.org/10.2139/ssrn.4068252. (iv) Villar J, Restrepo-Méndez M-C, McGready R, Barros FC, Victora CG, Munim S, Papageorghiou AT, Ochieng, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Zondervan KT, Winsey A, Nosten F, Uauy R, Bhutta ZA, and Kennedy SH. Preterm birth phenotypes have differential morbidity, growth and neurodevelopment at age 2: the INTERBIO-21st Newborn Study.JAMA Peds 2021 Mar 1;e206087. doi: 10.1001/jamapediatrics.2020.6087 (v) Kennedy SH, Victora CG, Craik R, Ash S, Barros FC, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Ismail LC, Lambert A. Deep clinical and biological phenotyping of the preterm birth and small for gestational age syndromes: The INTERBIO-21 st Newborn Case-Control Study protocol. Gates open research. 2018;2. (vi) Villar J, Restrepo-Méndez MC, McGready R, Fernandes M Bhutta ZA and Kennedy SH. Association Between Preterm-Birth Phenotypes and Differential Morbidity, Growth, and Neurodevelopment at Age 2 Years: Results From the INTERBIO-21st Newborn Study. JAMA Pediatrics. March 2021. doi:10.1001/jamapediatrics.2020.6087 (vii) Villar J, Gunier RB, Tshivuila-Matala CO, Rauch SA, Nosten F, Ochieng R, Restrepo-Méndez MC, McGready R, Barros FC, Fernandes M, Carrara VI. Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study. Nature Medicine. 2021 Mar 18:1-6. (viii) Ohuma EO, Jabin J, Young MF Fernandes M Kennedy SH and Villar J. Association between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study. The Lancet Haematology (2023),https://doi.org/10.1016/S2352-3026(23)00170-9. |
| Start Year | 2014 |
| Description | The INTERBIO-21st Study |
| Organisation | Ministry of Health Sultanate of Oman |
| Country | Oman |
| Sector | Public |
| PI Contribution | Neurodevelopment Lead for Project, training of site teams in the INTERGROWTH-21st Neurodevelopment Package, reliability testing and standardisation, implementation of Package at 8 project sites, QC, data analysis, manuscript preparation and publication, presentation of results. Funding Source: The Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator |
| Collaborator Contribution | Overall study design, funding, ethics and implementation of fetal (ultrasound), anthropometric and nutritional, and biosample collection aspects of the study. Data analysis and manuscript preparation. Development and maintenance of biobank. |
| Impact | Outputs: (i) establishment a biobank (INTERBIO-Bank) of maternal blood, maternal faeces and cord blood/placental samples from healthy and complicated pregnancies to allow nutritional, epigenetic and other biomarker studies to be performed (ii) Villar J, Ochieng R, Gunier RB, Papageorghiou AT, Rauch S, McGready R, Gauglitz JM, Barros FC, Vatish M, Fernandes M, Zammit V. Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity: prospective observational multinational INTERBIO-21st fetal study. The Lancet Diabetes & Endocrinology. 2022 Oct 1;10(10):710-9. (iii) Papageorghiou AT, Restrepo-Me´ndez MC, McGready R, Barros FC, Nosten F, Munim S, Ochieng R, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Winsey A, Uauy R, Bhutta ZA, Kennedy SH, Villar J. Aetiologically-Based Small for Gestational Age Phenotypes Have Differential Morbidity, Growth and Neurodevelopment at Age 2: The INTERBIO-21st Newborn Study. Lancet Child Adolesc Health. 28 March 2022. http://dx.doi.org/10.2139/ssrn.4068252. (iv) Villar J, Restrepo-Méndez M-C, McGready R, Barros FC, Victora CG, Munim S, Papageorghiou AT, Ochieng, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Zondervan KT, Winsey A, Nosten F, Uauy R, Bhutta ZA, and Kennedy SH. Preterm birth phenotypes have differential morbidity, growth and neurodevelopment at age 2: the INTERBIO-21st Newborn Study.JAMA Peds 2021 Mar 1;e206087. doi: 10.1001/jamapediatrics.2020.6087 (v) Kennedy SH, Victora CG, Craik R, Ash S, Barros FC, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Ismail LC, Lambert A. Deep clinical and biological phenotyping of the preterm birth and small for gestational age syndromes: The INTERBIO-21 st Newborn Case-Control Study protocol. Gates open research. 2018;2. (vi) Villar J, Restrepo-Méndez MC, McGready R, Fernandes M Bhutta ZA and Kennedy SH. Association Between Preterm-Birth Phenotypes and Differential Morbidity, Growth, and Neurodevelopment at Age 2 Years: Results From the INTERBIO-21st Newborn Study. JAMA Pediatrics. March 2021. doi:10.1001/jamapediatrics.2020.6087 (vii) Villar J, Gunier RB, Tshivuila-Matala CO, Rauch SA, Nosten F, Ochieng R, Restrepo-Méndez MC, McGready R, Barros FC, Fernandes M, Carrara VI. Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study. Nature Medicine. 2021 Mar 18:1-6. (viii) Ohuma EO, Jabin J, Young MF Fernandes M Kennedy SH and Villar J. Association between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study. The Lancet Haematology (2023),https://doi.org/10.1016/S2352-3026(23)00170-9. |
| Start Year | 2014 |
| Description | The INTERBIO-21st Study |
| Organisation | Providence Regional Medical Center Everett |
| Country | United States |
| Sector | Hospitals |
| PI Contribution | Neurodevelopment Lead for Project, training of site teams in the INTERGROWTH-21st Neurodevelopment Package, reliability testing and standardisation, implementation of Package at 8 project sites, QC, data analysis, manuscript preparation and publication, presentation of results. Funding Source: The Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator |
| Collaborator Contribution | Overall study design, funding, ethics and implementation of fetal (ultrasound), anthropometric and nutritional, and biosample collection aspects of the study. Data analysis and manuscript preparation. Development and maintenance of biobank. |
| Impact | Outputs: (i) establishment a biobank (INTERBIO-Bank) of maternal blood, maternal faeces and cord blood/placental samples from healthy and complicated pregnancies to allow nutritional, epigenetic and other biomarker studies to be performed (ii) Villar J, Ochieng R, Gunier RB, Papageorghiou AT, Rauch S, McGready R, Gauglitz JM, Barros FC, Vatish M, Fernandes M, Zammit V. Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity: prospective observational multinational INTERBIO-21st fetal study. The Lancet Diabetes & Endocrinology. 2022 Oct 1;10(10):710-9. (iii) Papageorghiou AT, Restrepo-Me´ndez MC, McGready R, Barros FC, Nosten F, Munim S, Ochieng R, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Winsey A, Uauy R, Bhutta ZA, Kennedy SH, Villar J. Aetiologically-Based Small for Gestational Age Phenotypes Have Differential Morbidity, Growth and Neurodevelopment at Age 2: The INTERBIO-21st Newborn Study. Lancet Child Adolesc Health. 28 March 2022. http://dx.doi.org/10.2139/ssrn.4068252. (iv) Villar J, Restrepo-Méndez M-C, McGready R, Barros FC, Victora CG, Munim S, Papageorghiou AT, Ochieng, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Zondervan KT, Winsey A, Nosten F, Uauy R, Bhutta ZA, and Kennedy SH. Preterm birth phenotypes have differential morbidity, growth and neurodevelopment at age 2: the INTERBIO-21st Newborn Study.JAMA Peds 2021 Mar 1;e206087. doi: 10.1001/jamapediatrics.2020.6087 (v) Kennedy SH, Victora CG, Craik R, Ash S, Barros FC, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Ismail LC, Lambert A. Deep clinical and biological phenotyping of the preterm birth and small for gestational age syndromes: The INTERBIO-21 st Newborn Case-Control Study protocol. Gates open research. 2018;2. (vi) Villar J, Restrepo-Méndez MC, McGready R, Fernandes M Bhutta ZA and Kennedy SH. Association Between Preterm-Birth Phenotypes and Differential Morbidity, Growth, and Neurodevelopment at Age 2 Years: Results From the INTERBIO-21st Newborn Study. JAMA Pediatrics. March 2021. doi:10.1001/jamapediatrics.2020.6087 (vii) Villar J, Gunier RB, Tshivuila-Matala CO, Rauch SA, Nosten F, Ochieng R, Restrepo-Méndez MC, McGready R, Barros FC, Fernandes M, Carrara VI. Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study. Nature Medicine. 2021 Mar 18:1-6. (viii) Ohuma EO, Jabin J, Young MF Fernandes M Kennedy SH and Villar J. Association between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study. The Lancet Haematology (2023),https://doi.org/10.1016/S2352-3026(23)00170-9. |
| Start Year | 2014 |
| Description | The INTERBIO-21st Study |
| Organisation | Swedish Medical Center |
| Country | United States |
| Sector | Hospitals |
| PI Contribution | Neurodevelopment Lead for Project, training of site teams in the INTERGROWTH-21st Neurodevelopment Package, reliability testing and standardisation, implementation of Package at 8 project sites, QC, data analysis, manuscript preparation and publication, presentation of results. Funding Source: The Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator |
| Collaborator Contribution | Overall study design, funding, ethics and implementation of fetal (ultrasound), anthropometric and nutritional, and biosample collection aspects of the study. Data analysis and manuscript preparation. Development and maintenance of biobank. |
| Impact | Outputs: (i) establishment a biobank (INTERBIO-Bank) of maternal blood, maternal faeces and cord blood/placental samples from healthy and complicated pregnancies to allow nutritional, epigenetic and other biomarker studies to be performed (ii) Villar J, Ochieng R, Gunier RB, Papageorghiou AT, Rauch S, McGready R, Gauglitz JM, Barros FC, Vatish M, Fernandes M, Zammit V. Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity: prospective observational multinational INTERBIO-21st fetal study. The Lancet Diabetes & Endocrinology. 2022 Oct 1;10(10):710-9. (iii) Papageorghiou AT, Restrepo-Me´ndez MC, McGready R, Barros FC, Nosten F, Munim S, Ochieng R, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Winsey A, Uauy R, Bhutta ZA, Kennedy SH, Villar J. Aetiologically-Based Small for Gestational Age Phenotypes Have Differential Morbidity, Growth and Neurodevelopment at Age 2: The INTERBIO-21st Newborn Study. Lancet Child Adolesc Health. 28 March 2022. http://dx.doi.org/10.2139/ssrn.4068252. (iv) Villar J, Restrepo-Méndez M-C, McGready R, Barros FC, Victora CG, Munim S, Papageorghiou AT, Ochieng, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Zondervan KT, Winsey A, Nosten F, Uauy R, Bhutta ZA, and Kennedy SH. Preterm birth phenotypes have differential morbidity, growth and neurodevelopment at age 2: the INTERBIO-21st Newborn Study.JAMA Peds 2021 Mar 1;e206087. doi: 10.1001/jamapediatrics.2020.6087 (v) Kennedy SH, Victora CG, Craik R, Ash S, Barros FC, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Ismail LC, Lambert A. Deep clinical and biological phenotyping of the preterm birth and small for gestational age syndromes: The INTERBIO-21 st Newborn Case-Control Study protocol. Gates open research. 2018;2. (vi) Villar J, Restrepo-Méndez MC, McGready R, Fernandes M Bhutta ZA and Kennedy SH. Association Between Preterm-Birth Phenotypes and Differential Morbidity, Growth, and Neurodevelopment at Age 2 Years: Results From the INTERBIO-21st Newborn Study. JAMA Pediatrics. March 2021. doi:10.1001/jamapediatrics.2020.6087 (vii) Villar J, Gunier RB, Tshivuila-Matala CO, Rauch SA, Nosten F, Ochieng R, Restrepo-Méndez MC, McGready R, Barros FC, Fernandes M, Carrara VI. Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study. Nature Medicine. 2021 Mar 18:1-6. (viii) Ohuma EO, Jabin J, Young MF Fernandes M Kennedy SH and Villar J. Association between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study. The Lancet Haematology (2023),https://doi.org/10.1016/S2352-3026(23)00170-9. |
| Start Year | 2014 |
| Description | The INTERBIO-21st Study |
| Organisation | University of Oxford |
| Department | Nuffield Department of Obstetrics & Gynaecology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Neurodevelopment Lead for Project, training of site teams in the INTERGROWTH-21st Neurodevelopment Package, reliability testing and standardisation, implementation of Package at 8 project sites, QC, data analysis, manuscript preparation and publication, presentation of results. Funding Source: The Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator |
| Collaborator Contribution | Overall study design, funding, ethics and implementation of fetal (ultrasound), anthropometric and nutritional, and biosample collection aspects of the study. Data analysis and manuscript preparation. Development and maintenance of biobank. |
| Impact | Outputs: (i) establishment a biobank (INTERBIO-Bank) of maternal blood, maternal faeces and cord blood/placental samples from healthy and complicated pregnancies to allow nutritional, epigenetic and other biomarker studies to be performed (ii) Villar J, Ochieng R, Gunier RB, Papageorghiou AT, Rauch S, McGready R, Gauglitz JM, Barros FC, Vatish M, Fernandes M, Zammit V. Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity: prospective observational multinational INTERBIO-21st fetal study. The Lancet Diabetes & Endocrinology. 2022 Oct 1;10(10):710-9. (iii) Papageorghiou AT, Restrepo-Me´ndez MC, McGready R, Barros FC, Nosten F, Munim S, Ochieng R, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Winsey A, Uauy R, Bhutta ZA, Kennedy SH, Villar J. Aetiologically-Based Small for Gestational Age Phenotypes Have Differential Morbidity, Growth and Neurodevelopment at Age 2: The INTERBIO-21st Newborn Study. Lancet Child Adolesc Health. 28 March 2022. http://dx.doi.org/10.2139/ssrn.4068252. (iv) Villar J, Restrepo-Méndez M-C, McGready R, Barros FC, Victora CG, Munim S, Papageorghiou AT, Ochieng, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Zondervan KT, Winsey A, Nosten F, Uauy R, Bhutta ZA, and Kennedy SH. Preterm birth phenotypes have differential morbidity, growth and neurodevelopment at age 2: the INTERBIO-21st Newborn Study.JAMA Peds 2021 Mar 1;e206087. doi: 10.1001/jamapediatrics.2020.6087 (v) Kennedy SH, Victora CG, Craik R, Ash S, Barros FC, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Ismail LC, Lambert A. Deep clinical and biological phenotyping of the preterm birth and small for gestational age syndromes: The INTERBIO-21 st Newborn Case-Control Study protocol. Gates open research. 2018;2. (vi) Villar J, Restrepo-Méndez MC, McGready R, Fernandes M Bhutta ZA and Kennedy SH. Association Between Preterm-Birth Phenotypes and Differential Morbidity, Growth, and Neurodevelopment at Age 2 Years: Results From the INTERBIO-21st Newborn Study. JAMA Pediatrics. March 2021. doi:10.1001/jamapediatrics.2020.6087 (vii) Villar J, Gunier RB, Tshivuila-Matala CO, Rauch SA, Nosten F, Ochieng R, Restrepo-Méndez MC, McGready R, Barros FC, Fernandes M, Carrara VI. Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study. Nature Medicine. 2021 Mar 18:1-6. (viii) Ohuma EO, Jabin J, Young MF Fernandes M Kennedy SH and Villar J. Association between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study. The Lancet Haematology (2023),https://doi.org/10.1016/S2352-3026(23)00170-9. |
| Start Year | 2014 |
| Description | The INTERBIO-21st Study |
| Organisation | University of Paris - Descartes |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Neurodevelopment Lead for Project, training of site teams in the INTERGROWTH-21st Neurodevelopment Package, reliability testing and standardisation, implementation of Package at 8 project sites, QC, data analysis, manuscript preparation and publication, presentation of results. Funding Source: The Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator |
| Collaborator Contribution | Overall study design, funding, ethics and implementation of fetal (ultrasound), anthropometric and nutritional, and biosample collection aspects of the study. Data analysis and manuscript preparation. Development and maintenance of biobank. |
| Impact | Outputs: (i) establishment a biobank (INTERBIO-Bank) of maternal blood, maternal faeces and cord blood/placental samples from healthy and complicated pregnancies to allow nutritional, epigenetic and other biomarker studies to be performed (ii) Villar J, Ochieng R, Gunier RB, Papageorghiou AT, Rauch S, McGready R, Gauglitz JM, Barros FC, Vatish M, Fernandes M, Zammit V. Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity: prospective observational multinational INTERBIO-21st fetal study. The Lancet Diabetes & Endocrinology. 2022 Oct 1;10(10):710-9. (iii) Papageorghiou AT, Restrepo-Me´ndez MC, McGready R, Barros FC, Nosten F, Munim S, Ochieng R, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Winsey A, Uauy R, Bhutta ZA, Kennedy SH, Villar J. Aetiologically-Based Small for Gestational Age Phenotypes Have Differential Morbidity, Growth and Neurodevelopment at Age 2: The INTERBIO-21st Newborn Study. Lancet Child Adolesc Health. 28 March 2022. http://dx.doi.org/10.2139/ssrn.4068252. (iv) Villar J, Restrepo-Méndez M-C, McGready R, Barros FC, Victora CG, Munim S, Papageorghiou AT, Ochieng, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Zondervan KT, Winsey A, Nosten F, Uauy R, Bhutta ZA, and Kennedy SH. Preterm birth phenotypes have differential morbidity, growth and neurodevelopment at age 2: the INTERBIO-21st Newborn Study.JAMA Peds 2021 Mar 1;e206087. doi: 10.1001/jamapediatrics.2020.6087 (v) Kennedy SH, Victora CG, Craik R, Ash S, Barros FC, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Ismail LC, Lambert A. Deep clinical and biological phenotyping of the preterm birth and small for gestational age syndromes: The INTERBIO-21 st Newborn Case-Control Study protocol. Gates open research. 2018;2. (vi) Villar J, Restrepo-Méndez MC, McGready R, Fernandes M Bhutta ZA and Kennedy SH. Association Between Preterm-Birth Phenotypes and Differential Morbidity, Growth, and Neurodevelopment at Age 2 Years: Results From the INTERBIO-21st Newborn Study. JAMA Pediatrics. March 2021. doi:10.1001/jamapediatrics.2020.6087 (vii) Villar J, Gunier RB, Tshivuila-Matala CO, Rauch SA, Nosten F, Ochieng R, Restrepo-Méndez MC, McGready R, Barros FC, Fernandes M, Carrara VI. Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study. Nature Medicine. 2021 Mar 18:1-6. (viii) Ohuma EO, Jabin J, Young MF Fernandes M Kennedy SH and Villar J. Association between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study. The Lancet Haematology (2023),https://doi.org/10.1016/S2352-3026(23)00170-9. |
| Start Year | 2014 |
| Description | The INTERBIO-21st Study |
| Organisation | University of Southampton |
| Department | Paediatrics |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Neurodevelopment Lead for Project, training of site teams in the INTERGROWTH-21st Neurodevelopment Package, reliability testing and standardisation, implementation of Package at 8 project sites, QC, data analysis, manuscript preparation and publication, presentation of results. Funding Source: The Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator |
| Collaborator Contribution | Overall study design, funding, ethics and implementation of fetal (ultrasound), anthropometric and nutritional, and biosample collection aspects of the study. Data analysis and manuscript preparation. Development and maintenance of biobank. |
| Impact | Outputs: (i) establishment a biobank (INTERBIO-Bank) of maternal blood, maternal faeces and cord blood/placental samples from healthy and complicated pregnancies to allow nutritional, epigenetic and other biomarker studies to be performed (ii) Villar J, Ochieng R, Gunier RB, Papageorghiou AT, Rauch S, McGready R, Gauglitz JM, Barros FC, Vatish M, Fernandes M, Zammit V. Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity: prospective observational multinational INTERBIO-21st fetal study. The Lancet Diabetes & Endocrinology. 2022 Oct 1;10(10):710-9. (iii) Papageorghiou AT, Restrepo-Me´ndez MC, McGready R, Barros FC, Nosten F, Munim S, Ochieng R, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Winsey A, Uauy R, Bhutta ZA, Kennedy SH, Villar J. Aetiologically-Based Small for Gestational Age Phenotypes Have Differential Morbidity, Growth and Neurodevelopment at Age 2: The INTERBIO-21st Newborn Study. Lancet Child Adolesc Health. 28 March 2022. http://dx.doi.org/10.2139/ssrn.4068252. (iv) Villar J, Restrepo-Méndez M-C, McGready R, Barros FC, Victora CG, Munim S, Papageorghiou AT, Ochieng, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Zondervan KT, Winsey A, Nosten F, Uauy R, Bhutta ZA, and Kennedy SH. Preterm birth phenotypes have differential morbidity, growth and neurodevelopment at age 2: the INTERBIO-21st Newborn Study.JAMA Peds 2021 Mar 1;e206087. doi: 10.1001/jamapediatrics.2020.6087 (v) Kennedy SH, Victora CG, Craik R, Ash S, Barros FC, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Ismail LC, Lambert A. Deep clinical and biological phenotyping of the preterm birth and small for gestational age syndromes: The INTERBIO-21 st Newborn Case-Control Study protocol. Gates open research. 2018;2. (vi) Villar J, Restrepo-Méndez MC, McGready R, Fernandes M Bhutta ZA and Kennedy SH. Association Between Preterm-Birth Phenotypes and Differential Morbidity, Growth, and Neurodevelopment at Age 2 Years: Results From the INTERBIO-21st Newborn Study. JAMA Pediatrics. March 2021. doi:10.1001/jamapediatrics.2020.6087 (vii) Villar J, Gunier RB, Tshivuila-Matala CO, Rauch SA, Nosten F, Ochieng R, Restrepo-Méndez MC, McGready R, Barros FC, Fernandes M, Carrara VI. Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study. Nature Medicine. 2021 Mar 18:1-6. (viii) Ohuma EO, Jabin J, Young MF Fernandes M Kennedy SH and Villar J. Association between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study. The Lancet Haematology (2023),https://doi.org/10.1016/S2352-3026(23)00170-9. |
| Start Year | 2014 |
| Description | The INTERBIO-21st Study |
| Organisation | University of Turin |
| Country | Italy |
| Sector | Academic/University |
| PI Contribution | Neurodevelopment Lead for Project, training of site teams in the INTERGROWTH-21st Neurodevelopment Package, reliability testing and standardisation, implementation of Package at 8 project sites, QC, data analysis, manuscript preparation and publication, presentation of results. Funding Source: The Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator |
| Collaborator Contribution | Overall study design, funding, ethics and implementation of fetal (ultrasound), anthropometric and nutritional, and biosample collection aspects of the study. Data analysis and manuscript preparation. Development and maintenance of biobank. |
| Impact | Outputs: (i) establishment a biobank (INTERBIO-Bank) of maternal blood, maternal faeces and cord blood/placental samples from healthy and complicated pregnancies to allow nutritional, epigenetic and other biomarker studies to be performed (ii) Villar J, Ochieng R, Gunier RB, Papageorghiou AT, Rauch S, McGready R, Gauglitz JM, Barros FC, Vatish M, Fernandes M, Zammit V. Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity: prospective observational multinational INTERBIO-21st fetal study. The Lancet Diabetes & Endocrinology. 2022 Oct 1;10(10):710-9. (iii) Papageorghiou AT, Restrepo-Me´ndez MC, McGready R, Barros FC, Nosten F, Munim S, Ochieng R, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Winsey A, Uauy R, Bhutta ZA, Kennedy SH, Villar J. Aetiologically-Based Small for Gestational Age Phenotypes Have Differential Morbidity, Growth and Neurodevelopment at Age 2: The INTERBIO-21st Newborn Study. Lancet Child Adolesc Health. 28 March 2022. http://dx.doi.org/10.2139/ssrn.4068252. (iv) Villar J, Restrepo-Méndez M-C, McGready R, Barros FC, Victora CG, Munim S, Papageorghiou AT, Ochieng, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Zondervan KT, Winsey A, Nosten F, Uauy R, Bhutta ZA, and Kennedy SH. Preterm birth phenotypes have differential morbidity, growth and neurodevelopment at age 2: the INTERBIO-21st Newborn Study.JAMA Peds 2021 Mar 1;e206087. doi: 10.1001/jamapediatrics.2020.6087 (v) Kennedy SH, Victora CG, Craik R, Ash S, Barros FC, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Ismail LC, Lambert A. Deep clinical and biological phenotyping of the preterm birth and small for gestational age syndromes: The INTERBIO-21 st Newborn Case-Control Study protocol. Gates open research. 2018;2. (vi) Villar J, Restrepo-Méndez MC, McGready R, Fernandes M Bhutta ZA and Kennedy SH. Association Between Preterm-Birth Phenotypes and Differential Morbidity, Growth, and Neurodevelopment at Age 2 Years: Results From the INTERBIO-21st Newborn Study. JAMA Pediatrics. March 2021. doi:10.1001/jamapediatrics.2020.6087 (vii) Villar J, Gunier RB, Tshivuila-Matala CO, Rauch SA, Nosten F, Ochieng R, Restrepo-Méndez MC, McGready R, Barros FC, Fernandes M, Carrara VI. Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study. Nature Medicine. 2021 Mar 18:1-6. (viii) Ohuma EO, Jabin J, Young MF Fernandes M Kennedy SH and Villar J. Association between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study. The Lancet Haematology (2023),https://doi.org/10.1016/S2352-3026(23)00170-9. |
| Start Year | 2014 |
| Description | The INTERBIO-21st Study |
| Organisation | University of Washington |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Neurodevelopment Lead for Project, training of site teams in the INTERGROWTH-21st Neurodevelopment Package, reliability testing and standardisation, implementation of Package at 8 project sites, QC, data analysis, manuscript preparation and publication, presentation of results. Funding Source: The Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator |
| Collaborator Contribution | Overall study design, funding, ethics and implementation of fetal (ultrasound), anthropometric and nutritional, and biosample collection aspects of the study. Data analysis and manuscript preparation. Development and maintenance of biobank. |
| Impact | Outputs: (i) establishment a biobank (INTERBIO-Bank) of maternal blood, maternal faeces and cord blood/placental samples from healthy and complicated pregnancies to allow nutritional, epigenetic and other biomarker studies to be performed (ii) Villar J, Ochieng R, Gunier RB, Papageorghiou AT, Rauch S, McGready R, Gauglitz JM, Barros FC, Vatish M, Fernandes M, Zammit V. Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity: prospective observational multinational INTERBIO-21st fetal study. The Lancet Diabetes & Endocrinology. 2022 Oct 1;10(10):710-9. (iii) Papageorghiou AT, Restrepo-Me´ndez MC, McGready R, Barros FC, Nosten F, Munim S, Ochieng R, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Winsey A, Uauy R, Bhutta ZA, Kennedy SH, Villar J. Aetiologically-Based Small for Gestational Age Phenotypes Have Differential Morbidity, Growth and Neurodevelopment at Age 2: The INTERBIO-21st Newborn Study. Lancet Child Adolesc Health. 28 March 2022. http://dx.doi.org/10.2139/ssrn.4068252. (iv) Villar J, Restrepo-Méndez M-C, McGready R, Barros FC, Victora CG, Munim S, Papageorghiou AT, Ochieng, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Zondervan KT, Winsey A, Nosten F, Uauy R, Bhutta ZA, and Kennedy SH. Preterm birth phenotypes have differential morbidity, growth and neurodevelopment at age 2: the INTERBIO-21st Newborn Study.JAMA Peds 2021 Mar 1;e206087. doi: 10.1001/jamapediatrics.2020.6087 (v) Kennedy SH, Victora CG, Craik R, Ash S, Barros FC, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Ismail LC, Lambert A. Deep clinical and biological phenotyping of the preterm birth and small for gestational age syndromes: The INTERBIO-21 st Newborn Case-Control Study protocol. Gates open research. 2018;2. (vi) Villar J, Restrepo-Méndez MC, McGready R, Fernandes M Bhutta ZA and Kennedy SH. Association Between Preterm-Birth Phenotypes and Differential Morbidity, Growth, and Neurodevelopment at Age 2 Years: Results From the INTERBIO-21st Newborn Study. JAMA Pediatrics. March 2021. doi:10.1001/jamapediatrics.2020.6087 (vii) Villar J, Gunier RB, Tshivuila-Matala CO, Rauch SA, Nosten F, Ochieng R, Restrepo-Méndez MC, McGready R, Barros FC, Fernandes M, Carrara VI. Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study. Nature Medicine. 2021 Mar 18:1-6. (viii) Ohuma EO, Jabin J, Young MF Fernandes M Kennedy SH and Villar J. Association between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study. The Lancet Haematology (2023),https://doi.org/10.1016/S2352-3026(23)00170-9. |
| Start Year | 2014 |
| Description | The INTERGROWTH-21st Project |
| Organisation | Federal University of Pelotas (UFPel) |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | (1) Design and development of the INTERGROWTH-21st Neurodevelopment Assessment Package, a holistic tool to measure multiple domains of neurodevelopment at 2 years of age in 45 minutes by non-specialists. I designed and supervised the implementation of the piloting of this tool. (2) Design and co-development of software associated with this tool, including the design of the NeuroApp (a tablet based application for data recording and upload with integrated QCs and manuals), and the ERP processing pipeline (together with STARLAB Barcelona) (3) Design of training packages and training of team in 5 project sites (India, Italy, Kenya, the UK and Brazil) (4) Regular QC and management of site teams as NEURODEVELOPMENT LEAD for the Project (5) Development and implementation of Standardization protocol in 4 sites (6) Initiation and management of research collaborations, including IP issues and the founding of the INTER-NDA consortium (a data sharing initiative between adopters of the Package) (7) Development and maintenance of the INTER-NDA website (8) Data analysis and key publication generation (ONGOING) (9) Dissemination of the package and support for adopters through training, consultancy, implementation, data analysis and publications (ONGOING) (10) Presentation of the Package at key meetings including at the WHO, the Bill and Melinda Gates Foundation, and the Carlos Slim Health Foundation. Funding Source: Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator, OMPHI Fellow (previous) |
| Collaborator Contribution | My partners in neurodevelopment have contributed through supporting me, by providing expert advice, in the design and development of the package and in the analysis and writing up of the data. My technical partners in Mexico and Spain have worked with me on the software and hardware aspects of the Package. My site-based collaborators have implemented the package. My partners (and PIs) in Obstetrics and Gynaecology in Oxford were responsible for securing the grant and for the fetal and neonatal growth aspects of the INTERGROWTH-21st Project, whose primary aim was to develop international prescriptive standards of fetal and newborn growth. |
| Impact | Outcomes: Products - (i) The INTERGROWTH-21st Neurodevelopment Package (ii) the INTER-NDA and (iii) The INTER-NDA consortium (see www.inter-nda.com). Publications - 4 background and methodology papers published, 1 accepted by PLoS One (awaiting publication), 2 being amended for re-sbumission following rejection from PLoS One, 3 in process of data being analysed and papers writing up. 5 operation manuals have been published online - see www.inter-nda.com. Adoption - the Package/INTER-NDA has been adopted by 8 independent research studies spanning 9 countries. Recognition - the Package has featured as one of the top 10 candidates for neurodevelopment assessment by the WHO technical consultation on early child development. This collaboration is multi-disciplinary and involves the following disciplines: Paediatrics, Neonatology, Obstetrics and Gynaecology, Child Psychiatry, Epidemiology, Statistics, Clinical Neurosciences, Child Health Publications: 1. Fernandes M*, Villar J, Stein A, Urias ES, Garza C, Victora CG, Barros FC, Bertino E, Purwar M, Carvalho M, Giuliani F. INTERGROWTH-21st Project international INTER-NDA standards for child development at 2 years of age: an international prospective population-based study. BMJ Open. 2020 Jun 1;10(6):e035258. 2. Villar J, Fernandes M, Purwar M, Staines-Urias E, Di Nicola P, Ismail LC, Ochieng R, Barros F, Albernaz E, Victora C, Kunnawar N. Neurodevelopmental milestones and associated behaviours are similar among healthy children across diverse geographical locations. Nature communications. 2019 Jan 30;10(1):1-0. 3. Fernandes M*, Ayede AI & Blackmon K. Addressing racial inequities in neuropsychological assessment requires international prescriptive standards, not demographically adjusted norms. Nat Rev Neurol (2022). https://doi.org/10.1038/s41582-022-00652-7 4. Namburete AIL, Papiez BW, Fernandes M. et al. Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years. Nature (2023). https://doi.org/10.1038/s41586-023-06630-3 5. Fernandes M*, Stein A, Newton CR, Cheikh-Ismail L, Kihara M, Wulff K, de León Quintana E, Aranzeta L, Soria-Frisch A, Acedo J, Ibanez D. The INTERGROWTH-21 st Project Neurodevelopment Package: a novel method for the multi-dimensional assessment of neurodevelopment in pre-school age children. PloS one. 2014 Nov 25;9(11):e113360. 6. Frenquelli R, Ratcliff M, Villar De Onis J, Fernandes M, Barros F, Stein A, Hirst J, Papageorghiou AT, Kennedy SH, Villar J. Complex perinatal syndromes affecting early human growth and development: issues to consider to understand their aetiology and postnatal effects. Frontiers in Neuroscience.:439, 2022. 7. Villar J, Ochieng R, Staines-Urias E, Fernandes M, Ratcliff M, Purwar M, Barros F, Horta B, Ismail LC, Albernaz E, Kunnawar N. Late weaning and maternal closeness, associated with advanced motor and visual maturation, reinforce autonomy in healthy, 2-year-old children. Scientific reports. 2020 Mar 23;10(1):1-27. 8. Fernandes M*. Child developmental follow up in obstetric RCTs: a unique opportunity. BJOG: An International Journal of Obstetrics & Gynaecology. 2020 Mar;127(4):518-. 9. Villar J, Ismail LC, Urias ES, Giuliani F, Ohuma EO, Victora CG, Papageorghiou AT, Altman DG, Garza C, Barros FC, Puglia FFernandes M, Bhutta Z and Kennedy S. The satisfactory growth and development at 2 years of age of the INTERGROWTH-21st Fetal Growth Standards cohort support its appropriateness for constructing international standards. American journal of obstetrics and gynecology. 2018 Feb 1;218(2):S841-54. 10. Murray E, Fernandes M*, Newton CR, Abubakar A, Kennedy SH, Villar J, Stein A. Evaluation of the INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) in 2 year-old children. PLoS One. 2018 Feb 28;13(2):e0193406. 11. Murray E, Fernandes M, Fazel M, Kennedy SH, Villar J, Stein A. Differential effect of intrauterine growth restriction on childhood neurodevelopment: a systematic review. BJOG: An International Journal of Obstetrics & Gynaecology. 2015 Jul;122(8):1062-72. 12. Fernandes M*, Yang X, Li JY, Cheikh Ismail L. Smoking during pregnancy and vision difficulties in children: a systematic review. Acta Ophthalmologica. 2015 May;93(3):213-23. INTER-NDA e-calculator https://inter-nda.shinyapps.io/inter-nda/ Invited keynote presentations: 1. FinnBrain Congress, Turku, Finland, June 2023 2. Neurodays Conference, University of Aix Marseille, November 2023 Invited keynote speaker, Westminster Education Forum policy conference Child development in the first 1,001 days of life - Family Hubs programme implementation, early skills priorities, parental support and engagement, and creating a joined-up approach (June 2022) 3. British Association for Neonatal Neurodevelopmental Follow Up Study Day (BANNFU) (October 2022) 4. Infants Meet Neuroscience Workshop, University of Regensburg, Regensburg, Germany, funded by the Deutsche Forschungsgemeinschaft (October 2022) 5. The Matthews Fund and International Neuropsychological Society (INS) conference on "Strengthening Capacity for Neuropsychological Assessment in the English-Speaking Caribbean", Grenada, West Indies (2022) International Conferences Organised The RCPCH International Child Health Group Conference on "International Early Child Development: Silent Emergency or Unique Opportunity", November 2021 Capacity Development and International Trainings: 1. Author of the INTER-NDA and INTERGROWTH-21st Neurodevelopment Assessment Training Course (2013-): over 350 assessors trained in 19 countries, approx. 5-7 e-training sessions and 1-2 in person workshops a year. 2. Early child development training workshops (2 to 5 days) for undergraduate and postgraduate researchers: Brazil (2016), Finland (2014), India (2015 and 2018), Kenya (2014), Slovakia (2019), the UK (2012, 2014 and 2020), the USA (2016), and the West Indies (2014, 2016, 2018). Virtual workshops 2-3/year since 2019. Early career researchers: 1. Raquel Lima, research initiation award (2022-23) Medical students: 1. Fee Benz, University of Oxford (2022-4) PhD students: 1. PhD Steering Committee Member, Paula Mustonen and Inka Mattel, University of Turku, Finland (2015 to date) 2. PhD Steering Committee Member, Harsha Behura, KLE University, Bangalore, India (2024-) |
| Start Year | 2012 |
| Description | The INTERGROWTH-21st Project |
| Organisation | Kenyan Institute for Medical Research (KEMRI) |
| Country | Kenya |
| Sector | Public |
| PI Contribution | (1) Design and development of the INTERGROWTH-21st Neurodevelopment Assessment Package, a holistic tool to measure multiple domains of neurodevelopment at 2 years of age in 45 minutes by non-specialists. I designed and supervised the implementation of the piloting of this tool. (2) Design and co-development of software associated with this tool, including the design of the NeuroApp (a tablet based application for data recording and upload with integrated QCs and manuals), and the ERP processing pipeline (together with STARLAB Barcelona) (3) Design of training packages and training of team in 5 project sites (India, Italy, Kenya, the UK and Brazil) (4) Regular QC and management of site teams as NEURODEVELOPMENT LEAD for the Project (5) Development and implementation of Standardization protocol in 4 sites (6) Initiation and management of research collaborations, including IP issues and the founding of the INTER-NDA consortium (a data sharing initiative between adopters of the Package) (7) Development and maintenance of the INTER-NDA website (8) Data analysis and key publication generation (ONGOING) (9) Dissemination of the package and support for adopters through training, consultancy, implementation, data analysis and publications (ONGOING) (10) Presentation of the Package at key meetings including at the WHO, the Bill and Melinda Gates Foundation, and the Carlos Slim Health Foundation. Funding Source: Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator, OMPHI Fellow (previous) |
| Collaborator Contribution | My partners in neurodevelopment have contributed through supporting me, by providing expert advice, in the design and development of the package and in the analysis and writing up of the data. My technical partners in Mexico and Spain have worked with me on the software and hardware aspects of the Package. My site-based collaborators have implemented the package. My partners (and PIs) in Obstetrics and Gynaecology in Oxford were responsible for securing the grant and for the fetal and neonatal growth aspects of the INTERGROWTH-21st Project, whose primary aim was to develop international prescriptive standards of fetal and newborn growth. |
| Impact | Outcomes: Products - (i) The INTERGROWTH-21st Neurodevelopment Package (ii) the INTER-NDA and (iii) The INTER-NDA consortium (see www.inter-nda.com). Publications - 4 background and methodology papers published, 1 accepted by PLoS One (awaiting publication), 2 being amended for re-sbumission following rejection from PLoS One, 3 in process of data being analysed and papers writing up. 5 operation manuals have been published online - see www.inter-nda.com. Adoption - the Package/INTER-NDA has been adopted by 8 independent research studies spanning 9 countries. Recognition - the Package has featured as one of the top 10 candidates for neurodevelopment assessment by the WHO technical consultation on early child development. This collaboration is multi-disciplinary and involves the following disciplines: Paediatrics, Neonatology, Obstetrics and Gynaecology, Child Psychiatry, Epidemiology, Statistics, Clinical Neurosciences, Child Health Publications: 1. Fernandes M*, Villar J, Stein A, Urias ES, Garza C, Victora CG, Barros FC, Bertino E, Purwar M, Carvalho M, Giuliani F. INTERGROWTH-21st Project international INTER-NDA standards for child development at 2 years of age: an international prospective population-based study. BMJ Open. 2020 Jun 1;10(6):e035258. 2. Villar J, Fernandes M, Purwar M, Staines-Urias E, Di Nicola P, Ismail LC, Ochieng R, Barros F, Albernaz E, Victora C, Kunnawar N. Neurodevelopmental milestones and associated behaviours are similar among healthy children across diverse geographical locations. Nature communications. 2019 Jan 30;10(1):1-0. 3. Fernandes M*, Ayede AI & Blackmon K. Addressing racial inequities in neuropsychological assessment requires international prescriptive standards, not demographically adjusted norms. Nat Rev Neurol (2022). https://doi.org/10.1038/s41582-022-00652-7 4. Namburete AIL, Papiez BW, Fernandes M. et al. Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years. Nature (2023). https://doi.org/10.1038/s41586-023-06630-3 5. Fernandes M*, Stein A, Newton CR, Cheikh-Ismail L, Kihara M, Wulff K, de León Quintana E, Aranzeta L, Soria-Frisch A, Acedo J, Ibanez D. The INTERGROWTH-21 st Project Neurodevelopment Package: a novel method for the multi-dimensional assessment of neurodevelopment in pre-school age children. PloS one. 2014 Nov 25;9(11):e113360. 6. Frenquelli R, Ratcliff M, Villar De Onis J, Fernandes M, Barros F, Stein A, Hirst J, Papageorghiou AT, Kennedy SH, Villar J. Complex perinatal syndromes affecting early human growth and development: issues to consider to understand their aetiology and postnatal effects. Frontiers in Neuroscience.:439, 2022. 7. Villar J, Ochieng R, Staines-Urias E, Fernandes M, Ratcliff M, Purwar M, Barros F, Horta B, Ismail LC, Albernaz E, Kunnawar N. Late weaning and maternal closeness, associated with advanced motor and visual maturation, reinforce autonomy in healthy, 2-year-old children. Scientific reports. 2020 Mar 23;10(1):1-27. 8. Fernandes M*. Child developmental follow up in obstetric RCTs: a unique opportunity. BJOG: An International Journal of Obstetrics & Gynaecology. 2020 Mar;127(4):518-. 9. Villar J, Ismail LC, Urias ES, Giuliani F, Ohuma EO, Victora CG, Papageorghiou AT, Altman DG, Garza C, Barros FC, Puglia FFernandes M, Bhutta Z and Kennedy S. The satisfactory growth and development at 2 years of age of the INTERGROWTH-21st Fetal Growth Standards cohort support its appropriateness for constructing international standards. American journal of obstetrics and gynecology. 2018 Feb 1;218(2):S841-54. 10. Murray E, Fernandes M*, Newton CR, Abubakar A, Kennedy SH, Villar J, Stein A. Evaluation of the INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) in 2 year-old children. PLoS One. 2018 Feb 28;13(2):e0193406. 11. Murray E, Fernandes M, Fazel M, Kennedy SH, Villar J, Stein A. Differential effect of intrauterine growth restriction on childhood neurodevelopment: a systematic review. BJOG: An International Journal of Obstetrics & Gynaecology. 2015 Jul;122(8):1062-72. 12. Fernandes M*, Yang X, Li JY, Cheikh Ismail L. Smoking during pregnancy and vision difficulties in children: a systematic review. Acta Ophthalmologica. 2015 May;93(3):213-23. INTER-NDA e-calculator https://inter-nda.shinyapps.io/inter-nda/ Invited keynote presentations: 1. FinnBrain Congress, Turku, Finland, June 2023 2. Neurodays Conference, University of Aix Marseille, November 2023 Invited keynote speaker, Westminster Education Forum policy conference Child development in the first 1,001 days of life - Family Hubs programme implementation, early skills priorities, parental support and engagement, and creating a joined-up approach (June 2022) 3. British Association for Neonatal Neurodevelopmental Follow Up Study Day (BANNFU) (October 2022) 4. Infants Meet Neuroscience Workshop, University of Regensburg, Regensburg, Germany, funded by the Deutsche Forschungsgemeinschaft (October 2022) 5. The Matthews Fund and International Neuropsychological Society (INS) conference on "Strengthening Capacity for Neuropsychological Assessment in the English-Speaking Caribbean", Grenada, West Indies (2022) International Conferences Organised The RCPCH International Child Health Group Conference on "International Early Child Development: Silent Emergency or Unique Opportunity", November 2021 Capacity Development and International Trainings: 1. Author of the INTER-NDA and INTERGROWTH-21st Neurodevelopment Assessment Training Course (2013-): over 350 assessors trained in 19 countries, approx. 5-7 e-training sessions and 1-2 in person workshops a year. 2. Early child development training workshops (2 to 5 days) for undergraduate and postgraduate researchers: Brazil (2016), Finland (2014), India (2015 and 2018), Kenya (2014), Slovakia (2019), the UK (2012, 2014 and 2020), the USA (2016), and the West Indies (2014, 2016, 2018). Virtual workshops 2-3/year since 2019. Early career researchers: 1. Raquel Lima, research initiation award (2022-23) Medical students: 1. Fee Benz, University of Oxford (2022-4) PhD students: 1. PhD Steering Committee Member, Paula Mustonen and Inka Mattel, University of Turku, Finland (2015 to date) 2. PhD Steering Committee Member, Harsha Behura, KLE University, Bangalore, India (2024-) |
| Start Year | 2012 |
| Description | The INTERGROWTH-21st Project |
| Organisation | Ketkar Hospital |
| Country | India |
| Sector | Hospitals |
| PI Contribution | (1) Design and development of the INTERGROWTH-21st Neurodevelopment Assessment Package, a holistic tool to measure multiple domains of neurodevelopment at 2 years of age in 45 minutes by non-specialists. I designed and supervised the implementation of the piloting of this tool. (2) Design and co-development of software associated with this tool, including the design of the NeuroApp (a tablet based application for data recording and upload with integrated QCs and manuals), and the ERP processing pipeline (together with STARLAB Barcelona) (3) Design of training packages and training of team in 5 project sites (India, Italy, Kenya, the UK and Brazil) (4) Regular QC and management of site teams as NEURODEVELOPMENT LEAD for the Project (5) Development and implementation of Standardization protocol in 4 sites (6) Initiation and management of research collaborations, including IP issues and the founding of the INTER-NDA consortium (a data sharing initiative between adopters of the Package) (7) Development and maintenance of the INTER-NDA website (8) Data analysis and key publication generation (ONGOING) (9) Dissemination of the package and support for adopters through training, consultancy, implementation, data analysis and publications (ONGOING) (10) Presentation of the Package at key meetings including at the WHO, the Bill and Melinda Gates Foundation, and the Carlos Slim Health Foundation. Funding Source: Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator, OMPHI Fellow (previous) |
| Collaborator Contribution | My partners in neurodevelopment have contributed through supporting me, by providing expert advice, in the design and development of the package and in the analysis and writing up of the data. My technical partners in Mexico and Spain have worked with me on the software and hardware aspects of the Package. My site-based collaborators have implemented the package. My partners (and PIs) in Obstetrics and Gynaecology in Oxford were responsible for securing the grant and for the fetal and neonatal growth aspects of the INTERGROWTH-21st Project, whose primary aim was to develop international prescriptive standards of fetal and newborn growth. |
| Impact | Outcomes: Products - (i) The INTERGROWTH-21st Neurodevelopment Package (ii) the INTER-NDA and (iii) The INTER-NDA consortium (see www.inter-nda.com). Publications - 4 background and methodology papers published, 1 accepted by PLoS One (awaiting publication), 2 being amended for re-sbumission following rejection from PLoS One, 3 in process of data being analysed and papers writing up. 5 operation manuals have been published online - see www.inter-nda.com. Adoption - the Package/INTER-NDA has been adopted by 8 independent research studies spanning 9 countries. Recognition - the Package has featured as one of the top 10 candidates for neurodevelopment assessment by the WHO technical consultation on early child development. This collaboration is multi-disciplinary and involves the following disciplines: Paediatrics, Neonatology, Obstetrics and Gynaecology, Child Psychiatry, Epidemiology, Statistics, Clinical Neurosciences, Child Health Publications: 1. Fernandes M*, Villar J, Stein A, Urias ES, Garza C, Victora CG, Barros FC, Bertino E, Purwar M, Carvalho M, Giuliani F. INTERGROWTH-21st Project international INTER-NDA standards for child development at 2 years of age: an international prospective population-based study. BMJ Open. 2020 Jun 1;10(6):e035258. 2. Villar J, Fernandes M, Purwar M, Staines-Urias E, Di Nicola P, Ismail LC, Ochieng R, Barros F, Albernaz E, Victora C, Kunnawar N. Neurodevelopmental milestones and associated behaviours are similar among healthy children across diverse geographical locations. Nature communications. 2019 Jan 30;10(1):1-0. 3. Fernandes M*, Ayede AI & Blackmon K. Addressing racial inequities in neuropsychological assessment requires international prescriptive standards, not demographically adjusted norms. Nat Rev Neurol (2022). https://doi.org/10.1038/s41582-022-00652-7 4. Namburete AIL, Papiez BW, Fernandes M. et al. Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years. Nature (2023). https://doi.org/10.1038/s41586-023-06630-3 5. Fernandes M*, Stein A, Newton CR, Cheikh-Ismail L, Kihara M, Wulff K, de León Quintana E, Aranzeta L, Soria-Frisch A, Acedo J, Ibanez D. The INTERGROWTH-21 st Project Neurodevelopment Package: a novel method for the multi-dimensional assessment of neurodevelopment in pre-school age children. PloS one. 2014 Nov 25;9(11):e113360. 6. Frenquelli R, Ratcliff M, Villar De Onis J, Fernandes M, Barros F, Stein A, Hirst J, Papageorghiou AT, Kennedy SH, Villar J. Complex perinatal syndromes affecting early human growth and development: issues to consider to understand their aetiology and postnatal effects. Frontiers in Neuroscience.:439, 2022. 7. Villar J, Ochieng R, Staines-Urias E, Fernandes M, Ratcliff M, Purwar M, Barros F, Horta B, Ismail LC, Albernaz E, Kunnawar N. Late weaning and maternal closeness, associated with advanced motor and visual maturation, reinforce autonomy in healthy, 2-year-old children. Scientific reports. 2020 Mar 23;10(1):1-27. 8. Fernandes M*. Child developmental follow up in obstetric RCTs: a unique opportunity. BJOG: An International Journal of Obstetrics & Gynaecology. 2020 Mar;127(4):518-. 9. Villar J, Ismail LC, Urias ES, Giuliani F, Ohuma EO, Victora CG, Papageorghiou AT, Altman DG, Garza C, Barros FC, Puglia FFernandes M, Bhutta Z and Kennedy S. The satisfactory growth and development at 2 years of age of the INTERGROWTH-21st Fetal Growth Standards cohort support its appropriateness for constructing international standards. American journal of obstetrics and gynecology. 2018 Feb 1;218(2):S841-54. 10. Murray E, Fernandes M*, Newton CR, Abubakar A, Kennedy SH, Villar J, Stein A. Evaluation of the INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) in 2 year-old children. PLoS One. 2018 Feb 28;13(2):e0193406. 11. Murray E, Fernandes M, Fazel M, Kennedy SH, Villar J, Stein A. Differential effect of intrauterine growth restriction on childhood neurodevelopment: a systematic review. BJOG: An International Journal of Obstetrics & Gynaecology. 2015 Jul;122(8):1062-72. 12. Fernandes M*, Yang X, Li JY, Cheikh Ismail L. Smoking during pregnancy and vision difficulties in children: a systematic review. Acta Ophthalmologica. 2015 May;93(3):213-23. INTER-NDA e-calculator https://inter-nda.shinyapps.io/inter-nda/ Invited keynote presentations: 1. FinnBrain Congress, Turku, Finland, June 2023 2. Neurodays Conference, University of Aix Marseille, November 2023 Invited keynote speaker, Westminster Education Forum policy conference Child development in the first 1,001 days of life - Family Hubs programme implementation, early skills priorities, parental support and engagement, and creating a joined-up approach (June 2022) 3. British Association for Neonatal Neurodevelopmental Follow Up Study Day (BANNFU) (October 2022) 4. Infants Meet Neuroscience Workshop, University of Regensburg, Regensburg, Germany, funded by the Deutsche Forschungsgemeinschaft (October 2022) 5. The Matthews Fund and International Neuropsychological Society (INS) conference on "Strengthening Capacity for Neuropsychological Assessment in the English-Speaking Caribbean", Grenada, West Indies (2022) International Conferences Organised The RCPCH International Child Health Group Conference on "International Early Child Development: Silent Emergency or Unique Opportunity", November 2021 Capacity Development and International Trainings: 1. Author of the INTER-NDA and INTERGROWTH-21st Neurodevelopment Assessment Training Course (2013-): over 350 assessors trained in 19 countries, approx. 5-7 e-training sessions and 1-2 in person workshops a year. 2. Early child development training workshops (2 to 5 days) for undergraduate and postgraduate researchers: Brazil (2016), Finland (2014), India (2015 and 2018), Kenya (2014), Slovakia (2019), the UK (2012, 2014 and 2020), the USA (2016), and the West Indies (2014, 2016, 2018). Virtual workshops 2-3/year since 2019. Early career researchers: 1. Raquel Lima, research initiation award (2022-23) Medical students: 1. Fee Benz, University of Oxford (2022-4) PhD students: 1. PhD Steering Committee Member, Paula Mustonen and Inka Mattel, University of Turku, Finland (2015 to date) 2. PhD Steering Committee Member, Harsha Behura, KLE University, Bangalore, India (2024-) |
| Start Year | 2012 |
| Description | The INTERGROWTH-21st Project |
| Organisation | Polytechnic University of Catalonia |
| Department | Center for Innovation and Technology |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | (1) Design and development of the INTERGROWTH-21st Neurodevelopment Assessment Package, a holistic tool to measure multiple domains of neurodevelopment at 2 years of age in 45 minutes by non-specialists. I designed and supervised the implementation of the piloting of this tool. (2) Design and co-development of software associated with this tool, including the design of the NeuroApp (a tablet based application for data recording and upload with integrated QCs and manuals), and the ERP processing pipeline (together with STARLAB Barcelona) (3) Design of training packages and training of team in 5 project sites (India, Italy, Kenya, the UK and Brazil) (4) Regular QC and management of site teams as NEURODEVELOPMENT LEAD for the Project (5) Development and implementation of Standardization protocol in 4 sites (6) Initiation and management of research collaborations, including IP issues and the founding of the INTER-NDA consortium (a data sharing initiative between adopters of the Package) (7) Development and maintenance of the INTER-NDA website (8) Data analysis and key publication generation (ONGOING) (9) Dissemination of the package and support for adopters through training, consultancy, implementation, data analysis and publications (ONGOING) (10) Presentation of the Package at key meetings including at the WHO, the Bill and Melinda Gates Foundation, and the Carlos Slim Health Foundation. Funding Source: Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator, OMPHI Fellow (previous) |
| Collaborator Contribution | My partners in neurodevelopment have contributed through supporting me, by providing expert advice, in the design and development of the package and in the analysis and writing up of the data. My technical partners in Mexico and Spain have worked with me on the software and hardware aspects of the Package. My site-based collaborators have implemented the package. My partners (and PIs) in Obstetrics and Gynaecology in Oxford were responsible for securing the grant and for the fetal and neonatal growth aspects of the INTERGROWTH-21st Project, whose primary aim was to develop international prescriptive standards of fetal and newborn growth. |
| Impact | Outcomes: Products - (i) The INTERGROWTH-21st Neurodevelopment Package (ii) the INTER-NDA and (iii) The INTER-NDA consortium (see www.inter-nda.com). Publications - 4 background and methodology papers published, 1 accepted by PLoS One (awaiting publication), 2 being amended for re-sbumission following rejection from PLoS One, 3 in process of data being analysed and papers writing up. 5 operation manuals have been published online - see www.inter-nda.com. Adoption - the Package/INTER-NDA has been adopted by 8 independent research studies spanning 9 countries. Recognition - the Package has featured as one of the top 10 candidates for neurodevelopment assessment by the WHO technical consultation on early child development. This collaboration is multi-disciplinary and involves the following disciplines: Paediatrics, Neonatology, Obstetrics and Gynaecology, Child Psychiatry, Epidemiology, Statistics, Clinical Neurosciences, Child Health Publications: 1. Fernandes M*, Villar J, Stein A, Urias ES, Garza C, Victora CG, Barros FC, Bertino E, Purwar M, Carvalho M, Giuliani F. INTERGROWTH-21st Project international INTER-NDA standards for child development at 2 years of age: an international prospective population-based study. BMJ Open. 2020 Jun 1;10(6):e035258. 2. Villar J, Fernandes M, Purwar M, Staines-Urias E, Di Nicola P, Ismail LC, Ochieng R, Barros F, Albernaz E, Victora C, Kunnawar N. Neurodevelopmental milestones and associated behaviours are similar among healthy children across diverse geographical locations. Nature communications. 2019 Jan 30;10(1):1-0. 3. Fernandes M*, Ayede AI & Blackmon K. Addressing racial inequities in neuropsychological assessment requires international prescriptive standards, not demographically adjusted norms. Nat Rev Neurol (2022). https://doi.org/10.1038/s41582-022-00652-7 4. Namburete AIL, Papiez BW, Fernandes M. et al. Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years. Nature (2023). https://doi.org/10.1038/s41586-023-06630-3 5. Fernandes M*, Stein A, Newton CR, Cheikh-Ismail L, Kihara M, Wulff K, de León Quintana E, Aranzeta L, Soria-Frisch A, Acedo J, Ibanez D. The INTERGROWTH-21 st Project Neurodevelopment Package: a novel method for the multi-dimensional assessment of neurodevelopment in pre-school age children. PloS one. 2014 Nov 25;9(11):e113360. 6. Frenquelli R, Ratcliff M, Villar De Onis J, Fernandes M, Barros F, Stein A, Hirst J, Papageorghiou AT, Kennedy SH, Villar J. Complex perinatal syndromes affecting early human growth and development: issues to consider to understand their aetiology and postnatal effects. Frontiers in Neuroscience.:439, 2022. 7. Villar J, Ochieng R, Staines-Urias E, Fernandes M, Ratcliff M, Purwar M, Barros F, Horta B, Ismail LC, Albernaz E, Kunnawar N. Late weaning and maternal closeness, associated with advanced motor and visual maturation, reinforce autonomy in healthy, 2-year-old children. Scientific reports. 2020 Mar 23;10(1):1-27. 8. Fernandes M*. Child developmental follow up in obstetric RCTs: a unique opportunity. BJOG: An International Journal of Obstetrics & Gynaecology. 2020 Mar;127(4):518-. 9. Villar J, Ismail LC, Urias ES, Giuliani F, Ohuma EO, Victora CG, Papageorghiou AT, Altman DG, Garza C, Barros FC, Puglia FFernandes M, Bhutta Z and Kennedy S. The satisfactory growth and development at 2 years of age of the INTERGROWTH-21st Fetal Growth Standards cohort support its appropriateness for constructing international standards. American journal of obstetrics and gynecology. 2018 Feb 1;218(2):S841-54. 10. Murray E, Fernandes M*, Newton CR, Abubakar A, Kennedy SH, Villar J, Stein A. Evaluation of the INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) in 2 year-old children. PLoS One. 2018 Feb 28;13(2):e0193406. 11. Murray E, Fernandes M, Fazel M, Kennedy SH, Villar J, Stein A. Differential effect of intrauterine growth restriction on childhood neurodevelopment: a systematic review. BJOG: An International Journal of Obstetrics & Gynaecology. 2015 Jul;122(8):1062-72. 12. Fernandes M*, Yang X, Li JY, Cheikh Ismail L. Smoking during pregnancy and vision difficulties in children: a systematic review. Acta Ophthalmologica. 2015 May;93(3):213-23. INTER-NDA e-calculator https://inter-nda.shinyapps.io/inter-nda/ Invited keynote presentations: 1. FinnBrain Congress, Turku, Finland, June 2023 2. Neurodays Conference, University of Aix Marseille, November 2023 Invited keynote speaker, Westminster Education Forum policy conference Child development in the first 1,001 days of life - Family Hubs programme implementation, early skills priorities, parental support and engagement, and creating a joined-up approach (June 2022) 3. British Association for Neonatal Neurodevelopmental Follow Up Study Day (BANNFU) (October 2022) 4. Infants Meet Neuroscience Workshop, University of Regensburg, Regensburg, Germany, funded by the Deutsche Forschungsgemeinschaft (October 2022) 5. The Matthews Fund and International Neuropsychological Society (INS) conference on "Strengthening Capacity for Neuropsychological Assessment in the English-Speaking Caribbean", Grenada, West Indies (2022) International Conferences Organised The RCPCH International Child Health Group Conference on "International Early Child Development: Silent Emergency or Unique Opportunity", November 2021 Capacity Development and International Trainings: 1. Author of the INTER-NDA and INTERGROWTH-21st Neurodevelopment Assessment Training Course (2013-): over 350 assessors trained in 19 countries, approx. 5-7 e-training sessions and 1-2 in person workshops a year. 2. Early child development training workshops (2 to 5 days) for undergraduate and postgraduate researchers: Brazil (2016), Finland (2014), India (2015 and 2018), Kenya (2014), Slovakia (2019), the UK (2012, 2014 and 2020), the USA (2016), and the West Indies (2014, 2016, 2018). Virtual workshops 2-3/year since 2019. Early career researchers: 1. Raquel Lima, research initiation award (2022-23) Medical students: 1. Fee Benz, University of Oxford (2022-4) PhD students: 1. PhD Steering Committee Member, Paula Mustonen and Inka Mattel, University of Turku, Finland (2015 to date) 2. PhD Steering Committee Member, Harsha Behura, KLE University, Bangalore, India (2024-) |
| Start Year | 2012 |
| Description | The INTERGROWTH-21st Project |
| Organisation | Starlab |
| Country | Spain |
| Sector | Private |
| PI Contribution | (1) Design and development of the INTERGROWTH-21st Neurodevelopment Assessment Package, a holistic tool to measure multiple domains of neurodevelopment at 2 years of age in 45 minutes by non-specialists. I designed and supervised the implementation of the piloting of this tool. (2) Design and co-development of software associated with this tool, including the design of the NeuroApp (a tablet based application for data recording and upload with integrated QCs and manuals), and the ERP processing pipeline (together with STARLAB Barcelona) (3) Design of training packages and training of team in 5 project sites (India, Italy, Kenya, the UK and Brazil) (4) Regular QC and management of site teams as NEURODEVELOPMENT LEAD for the Project (5) Development and implementation of Standardization protocol in 4 sites (6) Initiation and management of research collaborations, including IP issues and the founding of the INTER-NDA consortium (a data sharing initiative between adopters of the Package) (7) Development and maintenance of the INTER-NDA website (8) Data analysis and key publication generation (ONGOING) (9) Dissemination of the package and support for adopters through training, consultancy, implementation, data analysis and publications (ONGOING) (10) Presentation of the Package at key meetings including at the WHO, the Bill and Melinda Gates Foundation, and the Carlos Slim Health Foundation. Funding Source: Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator, OMPHI Fellow (previous) |
| Collaborator Contribution | My partners in neurodevelopment have contributed through supporting me, by providing expert advice, in the design and development of the package and in the analysis and writing up of the data. My technical partners in Mexico and Spain have worked with me on the software and hardware aspects of the Package. My site-based collaborators have implemented the package. My partners (and PIs) in Obstetrics and Gynaecology in Oxford were responsible for securing the grant and for the fetal and neonatal growth aspects of the INTERGROWTH-21st Project, whose primary aim was to develop international prescriptive standards of fetal and newborn growth. |
| Impact | Outcomes: Products - (i) The INTERGROWTH-21st Neurodevelopment Package (ii) the INTER-NDA and (iii) The INTER-NDA consortium (see www.inter-nda.com). Publications - 4 background and methodology papers published, 1 accepted by PLoS One (awaiting publication), 2 being amended for re-sbumission following rejection from PLoS One, 3 in process of data being analysed and papers writing up. 5 operation manuals have been published online - see www.inter-nda.com. Adoption - the Package/INTER-NDA has been adopted by 8 independent research studies spanning 9 countries. Recognition - the Package has featured as one of the top 10 candidates for neurodevelopment assessment by the WHO technical consultation on early child development. This collaboration is multi-disciplinary and involves the following disciplines: Paediatrics, Neonatology, Obstetrics and Gynaecology, Child Psychiatry, Epidemiology, Statistics, Clinical Neurosciences, Child Health Publications: 1. Fernandes M*, Villar J, Stein A, Urias ES, Garza C, Victora CG, Barros FC, Bertino E, Purwar M, Carvalho M, Giuliani F. INTERGROWTH-21st Project international INTER-NDA standards for child development at 2 years of age: an international prospective population-based study. BMJ Open. 2020 Jun 1;10(6):e035258. 2. Villar J, Fernandes M, Purwar M, Staines-Urias E, Di Nicola P, Ismail LC, Ochieng R, Barros F, Albernaz E, Victora C, Kunnawar N. Neurodevelopmental milestones and associated behaviours are similar among healthy children across diverse geographical locations. Nature communications. 2019 Jan 30;10(1):1-0. 3. Fernandes M*, Ayede AI & Blackmon K. Addressing racial inequities in neuropsychological assessment requires international prescriptive standards, not demographically adjusted norms. Nat Rev Neurol (2022). https://doi.org/10.1038/s41582-022-00652-7 4. Namburete AIL, Papiez BW, Fernandes M. et al. Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years. Nature (2023). https://doi.org/10.1038/s41586-023-06630-3 5. Fernandes M*, Stein A, Newton CR, Cheikh-Ismail L, Kihara M, Wulff K, de León Quintana E, Aranzeta L, Soria-Frisch A, Acedo J, Ibanez D. The INTERGROWTH-21 st Project Neurodevelopment Package: a novel method for the multi-dimensional assessment of neurodevelopment in pre-school age children. PloS one. 2014 Nov 25;9(11):e113360. 6. Frenquelli R, Ratcliff M, Villar De Onis J, Fernandes M, Barros F, Stein A, Hirst J, Papageorghiou AT, Kennedy SH, Villar J. Complex perinatal syndromes affecting early human growth and development: issues to consider to understand their aetiology and postnatal effects. Frontiers in Neuroscience.:439, 2022. 7. Villar J, Ochieng R, Staines-Urias E, Fernandes M, Ratcliff M, Purwar M, Barros F, Horta B, Ismail LC, Albernaz E, Kunnawar N. Late weaning and maternal closeness, associated with advanced motor and visual maturation, reinforce autonomy in healthy, 2-year-old children. Scientific reports. 2020 Mar 23;10(1):1-27. 8. Fernandes M*. Child developmental follow up in obstetric RCTs: a unique opportunity. BJOG: An International Journal of Obstetrics & Gynaecology. 2020 Mar;127(4):518-. 9. Villar J, Ismail LC, Urias ES, Giuliani F, Ohuma EO, Victora CG, Papageorghiou AT, Altman DG, Garza C, Barros FC, Puglia FFernandes M, Bhutta Z and Kennedy S. The satisfactory growth and development at 2 years of age of the INTERGROWTH-21st Fetal Growth Standards cohort support its appropriateness for constructing international standards. American journal of obstetrics and gynecology. 2018 Feb 1;218(2):S841-54. 10. Murray E, Fernandes M*, Newton CR, Abubakar A, Kennedy SH, Villar J, Stein A. Evaluation of the INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) in 2 year-old children. PLoS One. 2018 Feb 28;13(2):e0193406. 11. Murray E, Fernandes M, Fazel M, Kennedy SH, Villar J, Stein A. Differential effect of intrauterine growth restriction on childhood neurodevelopment: a systematic review. BJOG: An International Journal of Obstetrics & Gynaecology. 2015 Jul;122(8):1062-72. 12. Fernandes M*, Yang X, Li JY, Cheikh Ismail L. Smoking during pregnancy and vision difficulties in children: a systematic review. Acta Ophthalmologica. 2015 May;93(3):213-23. INTER-NDA e-calculator https://inter-nda.shinyapps.io/inter-nda/ Invited keynote presentations: 1. FinnBrain Congress, Turku, Finland, June 2023 2. Neurodays Conference, University of Aix Marseille, November 2023 Invited keynote speaker, Westminster Education Forum policy conference Child development in the first 1,001 days of life - Family Hubs programme implementation, early skills priorities, parental support and engagement, and creating a joined-up approach (June 2022) 3. British Association for Neonatal Neurodevelopmental Follow Up Study Day (BANNFU) (October 2022) 4. Infants Meet Neuroscience Workshop, University of Regensburg, Regensburg, Germany, funded by the Deutsche Forschungsgemeinschaft (October 2022) 5. The Matthews Fund and International Neuropsychological Society (INS) conference on "Strengthening Capacity for Neuropsychological Assessment in the English-Speaking Caribbean", Grenada, West Indies (2022) International Conferences Organised The RCPCH International Child Health Group Conference on "International Early Child Development: Silent Emergency or Unique Opportunity", November 2021 Capacity Development and International Trainings: 1. Author of the INTER-NDA and INTERGROWTH-21st Neurodevelopment Assessment Training Course (2013-): over 350 assessors trained in 19 countries, approx. 5-7 e-training sessions and 1-2 in person workshops a year. 2. Early child development training workshops (2 to 5 days) for undergraduate and postgraduate researchers: Brazil (2016), Finland (2014), India (2015 and 2018), Kenya (2014), Slovakia (2019), the UK (2012, 2014 and 2020), the USA (2016), and the West Indies (2014, 2016, 2018). Virtual workshops 2-3/year since 2019. Early career researchers: 1. Raquel Lima, research initiation award (2022-23) Medical students: 1. Fee Benz, University of Oxford (2022-4) PhD students: 1. PhD Steering Committee Member, Paula Mustonen and Inka Mattel, University of Turku, Finland (2015 to date) 2. PhD Steering Committee Member, Harsha Behura, KLE University, Bangalore, India (2024-) |
| Start Year | 2012 |
| Description | The INTERGROWTH-21st Project |
| Organisation | University College London |
| Department | Institute of Child Health |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | (1) Design and development of the INTERGROWTH-21st Neurodevelopment Assessment Package, a holistic tool to measure multiple domains of neurodevelopment at 2 years of age in 45 minutes by non-specialists. I designed and supervised the implementation of the piloting of this tool. (2) Design and co-development of software associated with this tool, including the design of the NeuroApp (a tablet based application for data recording and upload with integrated QCs and manuals), and the ERP processing pipeline (together with STARLAB Barcelona) (3) Design of training packages and training of team in 5 project sites (India, Italy, Kenya, the UK and Brazil) (4) Regular QC and management of site teams as NEURODEVELOPMENT LEAD for the Project (5) Development and implementation of Standardization protocol in 4 sites (6) Initiation and management of research collaborations, including IP issues and the founding of the INTER-NDA consortium (a data sharing initiative between adopters of the Package) (7) Development and maintenance of the INTER-NDA website (8) Data analysis and key publication generation (ONGOING) (9) Dissemination of the package and support for adopters through training, consultancy, implementation, data analysis and publications (ONGOING) (10) Presentation of the Package at key meetings including at the WHO, the Bill and Melinda Gates Foundation, and the Carlos Slim Health Foundation. Funding Source: Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator, OMPHI Fellow (previous) |
| Collaborator Contribution | My partners in neurodevelopment have contributed through supporting me, by providing expert advice, in the design and development of the package and in the analysis and writing up of the data. My technical partners in Mexico and Spain have worked with me on the software and hardware aspects of the Package. My site-based collaborators have implemented the package. My partners (and PIs) in Obstetrics and Gynaecology in Oxford were responsible for securing the grant and for the fetal and neonatal growth aspects of the INTERGROWTH-21st Project, whose primary aim was to develop international prescriptive standards of fetal and newborn growth. |
| Impact | Outcomes: Products - (i) The INTERGROWTH-21st Neurodevelopment Package (ii) the INTER-NDA and (iii) The INTER-NDA consortium (see www.inter-nda.com). Publications - 4 background and methodology papers published, 1 accepted by PLoS One (awaiting publication), 2 being amended for re-sbumission following rejection from PLoS One, 3 in process of data being analysed and papers writing up. 5 operation manuals have been published online - see www.inter-nda.com. Adoption - the Package/INTER-NDA has been adopted by 8 independent research studies spanning 9 countries. Recognition - the Package has featured as one of the top 10 candidates for neurodevelopment assessment by the WHO technical consultation on early child development. This collaboration is multi-disciplinary and involves the following disciplines: Paediatrics, Neonatology, Obstetrics and Gynaecology, Child Psychiatry, Epidemiology, Statistics, Clinical Neurosciences, Child Health Publications: 1. Fernandes M*, Villar J, Stein A, Urias ES, Garza C, Victora CG, Barros FC, Bertino E, Purwar M, Carvalho M, Giuliani F. INTERGROWTH-21st Project international INTER-NDA standards for child development at 2 years of age: an international prospective population-based study. BMJ Open. 2020 Jun 1;10(6):e035258. 2. Villar J, Fernandes M, Purwar M, Staines-Urias E, Di Nicola P, Ismail LC, Ochieng R, Barros F, Albernaz E, Victora C, Kunnawar N. Neurodevelopmental milestones and associated behaviours are similar among healthy children across diverse geographical locations. Nature communications. 2019 Jan 30;10(1):1-0. 3. Fernandes M*, Ayede AI & Blackmon K. Addressing racial inequities in neuropsychological assessment requires international prescriptive standards, not demographically adjusted norms. Nat Rev Neurol (2022). https://doi.org/10.1038/s41582-022-00652-7 4. Namburete AIL, Papiez BW, Fernandes M. et al. Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years. Nature (2023). https://doi.org/10.1038/s41586-023-06630-3 5. Fernandes M*, Stein A, Newton CR, Cheikh-Ismail L, Kihara M, Wulff K, de León Quintana E, Aranzeta L, Soria-Frisch A, Acedo J, Ibanez D. The INTERGROWTH-21 st Project Neurodevelopment Package: a novel method for the multi-dimensional assessment of neurodevelopment in pre-school age children. PloS one. 2014 Nov 25;9(11):e113360. 6. Frenquelli R, Ratcliff M, Villar De Onis J, Fernandes M, Barros F, Stein A, Hirst J, Papageorghiou AT, Kennedy SH, Villar J. Complex perinatal syndromes affecting early human growth and development: issues to consider to understand their aetiology and postnatal effects. Frontiers in Neuroscience.:439, 2022. 7. Villar J, Ochieng R, Staines-Urias E, Fernandes M, Ratcliff M, Purwar M, Barros F, Horta B, Ismail LC, Albernaz E, Kunnawar N. Late weaning and maternal closeness, associated with advanced motor and visual maturation, reinforce autonomy in healthy, 2-year-old children. Scientific reports. 2020 Mar 23;10(1):1-27. 8. Fernandes M*. Child developmental follow up in obstetric RCTs: a unique opportunity. BJOG: An International Journal of Obstetrics & Gynaecology. 2020 Mar;127(4):518-. 9. Villar J, Ismail LC, Urias ES, Giuliani F, Ohuma EO, Victora CG, Papageorghiou AT, Altman DG, Garza C, Barros FC, Puglia FFernandes M, Bhutta Z and Kennedy S. The satisfactory growth and development at 2 years of age of the INTERGROWTH-21st Fetal Growth Standards cohort support its appropriateness for constructing international standards. American journal of obstetrics and gynecology. 2018 Feb 1;218(2):S841-54. 10. Murray E, Fernandes M*, Newton CR, Abubakar A, Kennedy SH, Villar J, Stein A. Evaluation of the INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) in 2 year-old children. PLoS One. 2018 Feb 28;13(2):e0193406. 11. Murray E, Fernandes M, Fazel M, Kennedy SH, Villar J, Stein A. Differential effect of intrauterine growth restriction on childhood neurodevelopment: a systematic review. BJOG: An International Journal of Obstetrics & Gynaecology. 2015 Jul;122(8):1062-72. 12. Fernandes M*, Yang X, Li JY, Cheikh Ismail L. Smoking during pregnancy and vision difficulties in children: a systematic review. Acta Ophthalmologica. 2015 May;93(3):213-23. INTER-NDA e-calculator https://inter-nda.shinyapps.io/inter-nda/ Invited keynote presentations: 1. FinnBrain Congress, Turku, Finland, June 2023 2. Neurodays Conference, University of Aix Marseille, November 2023 Invited keynote speaker, Westminster Education Forum policy conference Child development in the first 1,001 days of life - Family Hubs programme implementation, early skills priorities, parental support and engagement, and creating a joined-up approach (June 2022) 3. British Association for Neonatal Neurodevelopmental Follow Up Study Day (BANNFU) (October 2022) 4. Infants Meet Neuroscience Workshop, University of Regensburg, Regensburg, Germany, funded by the Deutsche Forschungsgemeinschaft (October 2022) 5. The Matthews Fund and International Neuropsychological Society (INS) conference on "Strengthening Capacity for Neuropsychological Assessment in the English-Speaking Caribbean", Grenada, West Indies (2022) International Conferences Organised The RCPCH International Child Health Group Conference on "International Early Child Development: Silent Emergency or Unique Opportunity", November 2021 Capacity Development and International Trainings: 1. Author of the INTER-NDA and INTERGROWTH-21st Neurodevelopment Assessment Training Course (2013-): over 350 assessors trained in 19 countries, approx. 5-7 e-training sessions and 1-2 in person workshops a year. 2. Early child development training workshops (2 to 5 days) for undergraduate and postgraduate researchers: Brazil (2016), Finland (2014), India (2015 and 2018), Kenya (2014), Slovakia (2019), the UK (2012, 2014 and 2020), the USA (2016), and the West Indies (2014, 2016, 2018). Virtual workshops 2-3/year since 2019. Early career researchers: 1. Raquel Lima, research initiation award (2022-23) Medical students: 1. Fee Benz, University of Oxford (2022-4) PhD students: 1. PhD Steering Committee Member, Paula Mustonen and Inka Mattel, University of Turku, Finland (2015 to date) 2. PhD Steering Committee Member, Harsha Behura, KLE University, Bangalore, India (2024-) |
| Start Year | 2012 |
| Description | The INTERGROWTH-21st Project |
| Organisation | University of Oxford |
| Department | Centre for Statistics in Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | (1) Design and development of the INTERGROWTH-21st Neurodevelopment Assessment Package, a holistic tool to measure multiple domains of neurodevelopment at 2 years of age in 45 minutes by non-specialists. I designed and supervised the implementation of the piloting of this tool. (2) Design and co-development of software associated with this tool, including the design of the NeuroApp (a tablet based application for data recording and upload with integrated QCs and manuals), and the ERP processing pipeline (together with STARLAB Barcelona) (3) Design of training packages and training of team in 5 project sites (India, Italy, Kenya, the UK and Brazil) (4) Regular QC and management of site teams as NEURODEVELOPMENT LEAD for the Project (5) Development and implementation of Standardization protocol in 4 sites (6) Initiation and management of research collaborations, including IP issues and the founding of the INTER-NDA consortium (a data sharing initiative between adopters of the Package) (7) Development and maintenance of the INTER-NDA website (8) Data analysis and key publication generation (ONGOING) (9) Dissemination of the package and support for adopters through training, consultancy, implementation, data analysis and publications (ONGOING) (10) Presentation of the Package at key meetings including at the WHO, the Bill and Melinda Gates Foundation, and the Carlos Slim Health Foundation. Funding Source: Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator, OMPHI Fellow (previous) |
| Collaborator Contribution | My partners in neurodevelopment have contributed through supporting me, by providing expert advice, in the design and development of the package and in the analysis and writing up of the data. My technical partners in Mexico and Spain have worked with me on the software and hardware aspects of the Package. My site-based collaborators have implemented the package. My partners (and PIs) in Obstetrics and Gynaecology in Oxford were responsible for securing the grant and for the fetal and neonatal growth aspects of the INTERGROWTH-21st Project, whose primary aim was to develop international prescriptive standards of fetal and newborn growth. |
| Impact | Outcomes: Products - (i) The INTERGROWTH-21st Neurodevelopment Package (ii) the INTER-NDA and (iii) The INTER-NDA consortium (see www.inter-nda.com). Publications - 4 background and methodology papers published, 1 accepted by PLoS One (awaiting publication), 2 being amended for re-sbumission following rejection from PLoS One, 3 in process of data being analysed and papers writing up. 5 operation manuals have been published online - see www.inter-nda.com. Adoption - the Package/INTER-NDA has been adopted by 8 independent research studies spanning 9 countries. Recognition - the Package has featured as one of the top 10 candidates for neurodevelopment assessment by the WHO technical consultation on early child development. This collaboration is multi-disciplinary and involves the following disciplines: Paediatrics, Neonatology, Obstetrics and Gynaecology, Child Psychiatry, Epidemiology, Statistics, Clinical Neurosciences, Child Health Publications: 1. Fernandes M*, Villar J, Stein A, Urias ES, Garza C, Victora CG, Barros FC, Bertino E, Purwar M, Carvalho M, Giuliani F. INTERGROWTH-21st Project international INTER-NDA standards for child development at 2 years of age: an international prospective population-based study. BMJ Open. 2020 Jun 1;10(6):e035258. 2. Villar J, Fernandes M, Purwar M, Staines-Urias E, Di Nicola P, Ismail LC, Ochieng R, Barros F, Albernaz E, Victora C, Kunnawar N. Neurodevelopmental milestones and associated behaviours are similar among healthy children across diverse geographical locations. Nature communications. 2019 Jan 30;10(1):1-0. 3. Fernandes M*, Ayede AI & Blackmon K. Addressing racial inequities in neuropsychological assessment requires international prescriptive standards, not demographically adjusted norms. Nat Rev Neurol (2022). https://doi.org/10.1038/s41582-022-00652-7 4. Namburete AIL, Papiez BW, Fernandes M. et al. Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years. Nature (2023). https://doi.org/10.1038/s41586-023-06630-3 5. Fernandes M*, Stein A, Newton CR, Cheikh-Ismail L, Kihara M, Wulff K, de León Quintana E, Aranzeta L, Soria-Frisch A, Acedo J, Ibanez D. The INTERGROWTH-21 st Project Neurodevelopment Package: a novel method for the multi-dimensional assessment of neurodevelopment in pre-school age children. PloS one. 2014 Nov 25;9(11):e113360. 6. Frenquelli R, Ratcliff M, Villar De Onis J, Fernandes M, Barros F, Stein A, Hirst J, Papageorghiou AT, Kennedy SH, Villar J. Complex perinatal syndromes affecting early human growth and development: issues to consider to understand their aetiology and postnatal effects. Frontiers in Neuroscience.:439, 2022. 7. Villar J, Ochieng R, Staines-Urias E, Fernandes M, Ratcliff M, Purwar M, Barros F, Horta B, Ismail LC, Albernaz E, Kunnawar N. Late weaning and maternal closeness, associated with advanced motor and visual maturation, reinforce autonomy in healthy, 2-year-old children. Scientific reports. 2020 Mar 23;10(1):1-27. 8. Fernandes M*. Child developmental follow up in obstetric RCTs: a unique opportunity. BJOG: An International Journal of Obstetrics & Gynaecology. 2020 Mar;127(4):518-. 9. Villar J, Ismail LC, Urias ES, Giuliani F, Ohuma EO, Victora CG, Papageorghiou AT, Altman DG, Garza C, Barros FC, Puglia FFernandes M, Bhutta Z and Kennedy S. The satisfactory growth and development at 2 years of age of the INTERGROWTH-21st Fetal Growth Standards cohort support its appropriateness for constructing international standards. American journal of obstetrics and gynecology. 2018 Feb 1;218(2):S841-54. 10. Murray E, Fernandes M*, Newton CR, Abubakar A, Kennedy SH, Villar J, Stein A. Evaluation of the INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) in 2 year-old children. PLoS One. 2018 Feb 28;13(2):e0193406. 11. Murray E, Fernandes M, Fazel M, Kennedy SH, Villar J, Stein A. Differential effect of intrauterine growth restriction on childhood neurodevelopment: a systematic review. BJOG: An International Journal of Obstetrics & Gynaecology. 2015 Jul;122(8):1062-72. 12. Fernandes M*, Yang X, Li JY, Cheikh Ismail L. Smoking during pregnancy and vision difficulties in children: a systematic review. Acta Ophthalmologica. 2015 May;93(3):213-23. INTER-NDA e-calculator https://inter-nda.shinyapps.io/inter-nda/ Invited keynote presentations: 1. FinnBrain Congress, Turku, Finland, June 2023 2. Neurodays Conference, University of Aix Marseille, November 2023 Invited keynote speaker, Westminster Education Forum policy conference Child development in the first 1,001 days of life - Family Hubs programme implementation, early skills priorities, parental support and engagement, and creating a joined-up approach (June 2022) 3. British Association for Neonatal Neurodevelopmental Follow Up Study Day (BANNFU) (October 2022) 4. Infants Meet Neuroscience Workshop, University of Regensburg, Regensburg, Germany, funded by the Deutsche Forschungsgemeinschaft (October 2022) 5. The Matthews Fund and International Neuropsychological Society (INS) conference on "Strengthening Capacity for Neuropsychological Assessment in the English-Speaking Caribbean", Grenada, West Indies (2022) International Conferences Organised The RCPCH International Child Health Group Conference on "International Early Child Development: Silent Emergency or Unique Opportunity", November 2021 Capacity Development and International Trainings: 1. Author of the INTER-NDA and INTERGROWTH-21st Neurodevelopment Assessment Training Course (2013-): over 350 assessors trained in 19 countries, approx. 5-7 e-training sessions and 1-2 in person workshops a year. 2. Early child development training workshops (2 to 5 days) for undergraduate and postgraduate researchers: Brazil (2016), Finland (2014), India (2015 and 2018), Kenya (2014), Slovakia (2019), the UK (2012, 2014 and 2020), the USA (2016), and the West Indies (2014, 2016, 2018). Virtual workshops 2-3/year since 2019. Early career researchers: 1. Raquel Lima, research initiation award (2022-23) Medical students: 1. Fee Benz, University of Oxford (2022-4) PhD students: 1. PhD Steering Committee Member, Paula Mustonen and Inka Mattel, University of Turku, Finland (2015 to date) 2. PhD Steering Committee Member, Harsha Behura, KLE University, Bangalore, India (2024-) |
| Start Year | 2012 |
| Description | The INTERGROWTH-21st Project |
| Organisation | University of Oxford |
| Department | Department of Psychiatry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | (1) Design and development of the INTERGROWTH-21st Neurodevelopment Assessment Package, a holistic tool to measure multiple domains of neurodevelopment at 2 years of age in 45 minutes by non-specialists. I designed and supervised the implementation of the piloting of this tool. (2) Design and co-development of software associated with this tool, including the design of the NeuroApp (a tablet based application for data recording and upload with integrated QCs and manuals), and the ERP processing pipeline (together with STARLAB Barcelona) (3) Design of training packages and training of team in 5 project sites (India, Italy, Kenya, the UK and Brazil) (4) Regular QC and management of site teams as NEURODEVELOPMENT LEAD for the Project (5) Development and implementation of Standardization protocol in 4 sites (6) Initiation and management of research collaborations, including IP issues and the founding of the INTER-NDA consortium (a data sharing initiative between adopters of the Package) (7) Development and maintenance of the INTER-NDA website (8) Data analysis and key publication generation (ONGOING) (9) Dissemination of the package and support for adopters through training, consultancy, implementation, data analysis and publications (ONGOING) (10) Presentation of the Package at key meetings including at the WHO, the Bill and Melinda Gates Foundation, and the Carlos Slim Health Foundation. Funding Source: Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator, OMPHI Fellow (previous) |
| Collaborator Contribution | My partners in neurodevelopment have contributed through supporting me, by providing expert advice, in the design and development of the package and in the analysis and writing up of the data. My technical partners in Mexico and Spain have worked with me on the software and hardware aspects of the Package. My site-based collaborators have implemented the package. My partners (and PIs) in Obstetrics and Gynaecology in Oxford were responsible for securing the grant and for the fetal and neonatal growth aspects of the INTERGROWTH-21st Project, whose primary aim was to develop international prescriptive standards of fetal and newborn growth. |
| Impact | Outcomes: Products - (i) The INTERGROWTH-21st Neurodevelopment Package (ii) the INTER-NDA and (iii) The INTER-NDA consortium (see www.inter-nda.com). Publications - 4 background and methodology papers published, 1 accepted by PLoS One (awaiting publication), 2 being amended for re-sbumission following rejection from PLoS One, 3 in process of data being analysed and papers writing up. 5 operation manuals have been published online - see www.inter-nda.com. Adoption - the Package/INTER-NDA has been adopted by 8 independent research studies spanning 9 countries. Recognition - the Package has featured as one of the top 10 candidates for neurodevelopment assessment by the WHO technical consultation on early child development. This collaboration is multi-disciplinary and involves the following disciplines: Paediatrics, Neonatology, Obstetrics and Gynaecology, Child Psychiatry, Epidemiology, Statistics, Clinical Neurosciences, Child Health Publications: 1. Fernandes M*, Villar J, Stein A, Urias ES, Garza C, Victora CG, Barros FC, Bertino E, Purwar M, Carvalho M, Giuliani F. INTERGROWTH-21st Project international INTER-NDA standards for child development at 2 years of age: an international prospective population-based study. BMJ Open. 2020 Jun 1;10(6):e035258. 2. Villar J, Fernandes M, Purwar M, Staines-Urias E, Di Nicola P, Ismail LC, Ochieng R, Barros F, Albernaz E, Victora C, Kunnawar N. Neurodevelopmental milestones and associated behaviours are similar among healthy children across diverse geographical locations. Nature communications. 2019 Jan 30;10(1):1-0. 3. Fernandes M*, Ayede AI & Blackmon K. Addressing racial inequities in neuropsychological assessment requires international prescriptive standards, not demographically adjusted norms. Nat Rev Neurol (2022). https://doi.org/10.1038/s41582-022-00652-7 4. Namburete AIL, Papiez BW, Fernandes M. et al. Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years. Nature (2023). https://doi.org/10.1038/s41586-023-06630-3 5. Fernandes M*, Stein A, Newton CR, Cheikh-Ismail L, Kihara M, Wulff K, de León Quintana E, Aranzeta L, Soria-Frisch A, Acedo J, Ibanez D. The INTERGROWTH-21 st Project Neurodevelopment Package: a novel method for the multi-dimensional assessment of neurodevelopment in pre-school age children. PloS one. 2014 Nov 25;9(11):e113360. 6. Frenquelli R, Ratcliff M, Villar De Onis J, Fernandes M, Barros F, Stein A, Hirst J, Papageorghiou AT, Kennedy SH, Villar J. Complex perinatal syndromes affecting early human growth and development: issues to consider to understand their aetiology and postnatal effects. Frontiers in Neuroscience.:439, 2022. 7. Villar J, Ochieng R, Staines-Urias E, Fernandes M, Ratcliff M, Purwar M, Barros F, Horta B, Ismail LC, Albernaz E, Kunnawar N. Late weaning and maternal closeness, associated with advanced motor and visual maturation, reinforce autonomy in healthy, 2-year-old children. Scientific reports. 2020 Mar 23;10(1):1-27. 8. Fernandes M*. Child developmental follow up in obstetric RCTs: a unique opportunity. BJOG: An International Journal of Obstetrics & Gynaecology. 2020 Mar;127(4):518-. 9. Villar J, Ismail LC, Urias ES, Giuliani F, Ohuma EO, Victora CG, Papageorghiou AT, Altman DG, Garza C, Barros FC, Puglia FFernandes M, Bhutta Z and Kennedy S. The satisfactory growth and development at 2 years of age of the INTERGROWTH-21st Fetal Growth Standards cohort support its appropriateness for constructing international standards. American journal of obstetrics and gynecology. 2018 Feb 1;218(2):S841-54. 10. Murray E, Fernandes M*, Newton CR, Abubakar A, Kennedy SH, Villar J, Stein A. Evaluation of the INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) in 2 year-old children. PLoS One. 2018 Feb 28;13(2):e0193406. 11. Murray E, Fernandes M, Fazel M, Kennedy SH, Villar J, Stein A. Differential effect of intrauterine growth restriction on childhood neurodevelopment: a systematic review. BJOG: An International Journal of Obstetrics & Gynaecology. 2015 Jul;122(8):1062-72. 12. Fernandes M*, Yang X, Li JY, Cheikh Ismail L. Smoking during pregnancy and vision difficulties in children: a systematic review. Acta Ophthalmologica. 2015 May;93(3):213-23. INTER-NDA e-calculator https://inter-nda.shinyapps.io/inter-nda/ Invited keynote presentations: 1. FinnBrain Congress, Turku, Finland, June 2023 2. Neurodays Conference, University of Aix Marseille, November 2023 Invited keynote speaker, Westminster Education Forum policy conference Child development in the first 1,001 days of life - Family Hubs programme implementation, early skills priorities, parental support and engagement, and creating a joined-up approach (June 2022) 3. British Association for Neonatal Neurodevelopmental Follow Up Study Day (BANNFU) (October 2022) 4. Infants Meet Neuroscience Workshop, University of Regensburg, Regensburg, Germany, funded by the Deutsche Forschungsgemeinschaft (October 2022) 5. The Matthews Fund and International Neuropsychological Society (INS) conference on "Strengthening Capacity for Neuropsychological Assessment in the English-Speaking Caribbean", Grenada, West Indies (2022) International Conferences Organised The RCPCH International Child Health Group Conference on "International Early Child Development: Silent Emergency or Unique Opportunity", November 2021 Capacity Development and International Trainings: 1. Author of the INTER-NDA and INTERGROWTH-21st Neurodevelopment Assessment Training Course (2013-): over 350 assessors trained in 19 countries, approx. 5-7 e-training sessions and 1-2 in person workshops a year. 2. Early child development training workshops (2 to 5 days) for undergraduate and postgraduate researchers: Brazil (2016), Finland (2014), India (2015 and 2018), Kenya (2014), Slovakia (2019), the UK (2012, 2014 and 2020), the USA (2016), and the West Indies (2014, 2016, 2018). Virtual workshops 2-3/year since 2019. Early career researchers: 1. Raquel Lima, research initiation award (2022-23) Medical students: 1. Fee Benz, University of Oxford (2022-4) PhD students: 1. PhD Steering Committee Member, Paula Mustonen and Inka Mattel, University of Turku, Finland (2015 to date) 2. PhD Steering Committee Member, Harsha Behura, KLE University, Bangalore, India (2024-) |
| Start Year | 2012 |
| Description | The INTERGROWTH-21st Project |
| Organisation | University of Oxford |
| Department | Nuffield Department of Clinical Neurosciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | (1) Design and development of the INTERGROWTH-21st Neurodevelopment Assessment Package, a holistic tool to measure multiple domains of neurodevelopment at 2 years of age in 45 minutes by non-specialists. I designed and supervised the implementation of the piloting of this tool. (2) Design and co-development of software associated with this tool, including the design of the NeuroApp (a tablet based application for data recording and upload with integrated QCs and manuals), and the ERP processing pipeline (together with STARLAB Barcelona) (3) Design of training packages and training of team in 5 project sites (India, Italy, Kenya, the UK and Brazil) (4) Regular QC and management of site teams as NEURODEVELOPMENT LEAD for the Project (5) Development and implementation of Standardization protocol in 4 sites (6) Initiation and management of research collaborations, including IP issues and the founding of the INTER-NDA consortium (a data sharing initiative between adopters of the Package) (7) Development and maintenance of the INTER-NDA website (8) Data analysis and key publication generation (ONGOING) (9) Dissemination of the package and support for adopters through training, consultancy, implementation, data analysis and publications (ONGOING) (10) Presentation of the Package at key meetings including at the WHO, the Bill and Melinda Gates Foundation, and the Carlos Slim Health Foundation. Funding Source: Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator, OMPHI Fellow (previous) |
| Collaborator Contribution | My partners in neurodevelopment have contributed through supporting me, by providing expert advice, in the design and development of the package and in the analysis and writing up of the data. My technical partners in Mexico and Spain have worked with me on the software and hardware aspects of the Package. My site-based collaborators have implemented the package. My partners (and PIs) in Obstetrics and Gynaecology in Oxford were responsible for securing the grant and for the fetal and neonatal growth aspects of the INTERGROWTH-21st Project, whose primary aim was to develop international prescriptive standards of fetal and newborn growth. |
| Impact | Outcomes: Products - (i) The INTERGROWTH-21st Neurodevelopment Package (ii) the INTER-NDA and (iii) The INTER-NDA consortium (see www.inter-nda.com). Publications - 4 background and methodology papers published, 1 accepted by PLoS One (awaiting publication), 2 being amended for re-sbumission following rejection from PLoS One, 3 in process of data being analysed and papers writing up. 5 operation manuals have been published online - see www.inter-nda.com. Adoption - the Package/INTER-NDA has been adopted by 8 independent research studies spanning 9 countries. Recognition - the Package has featured as one of the top 10 candidates for neurodevelopment assessment by the WHO technical consultation on early child development. This collaboration is multi-disciplinary and involves the following disciplines: Paediatrics, Neonatology, Obstetrics and Gynaecology, Child Psychiatry, Epidemiology, Statistics, Clinical Neurosciences, Child Health Publications: 1. Fernandes M*, Villar J, Stein A, Urias ES, Garza C, Victora CG, Barros FC, Bertino E, Purwar M, Carvalho M, Giuliani F. INTERGROWTH-21st Project international INTER-NDA standards for child development at 2 years of age: an international prospective population-based study. BMJ Open. 2020 Jun 1;10(6):e035258. 2. Villar J, Fernandes M, Purwar M, Staines-Urias E, Di Nicola P, Ismail LC, Ochieng R, Barros F, Albernaz E, Victora C, Kunnawar N. Neurodevelopmental milestones and associated behaviours are similar among healthy children across diverse geographical locations. Nature communications. 2019 Jan 30;10(1):1-0. 3. Fernandes M*, Ayede AI & Blackmon K. Addressing racial inequities in neuropsychological assessment requires international prescriptive standards, not demographically adjusted norms. Nat Rev Neurol (2022). https://doi.org/10.1038/s41582-022-00652-7 4. Namburete AIL, Papiez BW, Fernandes M. et al. Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years. Nature (2023). https://doi.org/10.1038/s41586-023-06630-3 5. Fernandes M*, Stein A, Newton CR, Cheikh-Ismail L, Kihara M, Wulff K, de León Quintana E, Aranzeta L, Soria-Frisch A, Acedo J, Ibanez D. The INTERGROWTH-21 st Project Neurodevelopment Package: a novel method for the multi-dimensional assessment of neurodevelopment in pre-school age children. PloS one. 2014 Nov 25;9(11):e113360. 6. Frenquelli R, Ratcliff M, Villar De Onis J, Fernandes M, Barros F, Stein A, Hirst J, Papageorghiou AT, Kennedy SH, Villar J. Complex perinatal syndromes affecting early human growth and development: issues to consider to understand their aetiology and postnatal effects. Frontiers in Neuroscience.:439, 2022. 7. Villar J, Ochieng R, Staines-Urias E, Fernandes M, Ratcliff M, Purwar M, Barros F, Horta B, Ismail LC, Albernaz E, Kunnawar N. Late weaning and maternal closeness, associated with advanced motor and visual maturation, reinforce autonomy in healthy, 2-year-old children. Scientific reports. 2020 Mar 23;10(1):1-27. 8. Fernandes M*. Child developmental follow up in obstetric RCTs: a unique opportunity. BJOG: An International Journal of Obstetrics & Gynaecology. 2020 Mar;127(4):518-. 9. Villar J, Ismail LC, Urias ES, Giuliani F, Ohuma EO, Victora CG, Papageorghiou AT, Altman DG, Garza C, Barros FC, Puglia FFernandes M, Bhutta Z and Kennedy S. The satisfactory growth and development at 2 years of age of the INTERGROWTH-21st Fetal Growth Standards cohort support its appropriateness for constructing international standards. American journal of obstetrics and gynecology. 2018 Feb 1;218(2):S841-54. 10. Murray E, Fernandes M*, Newton CR, Abubakar A, Kennedy SH, Villar J, Stein A. Evaluation of the INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) in 2 year-old children. PLoS One. 2018 Feb 28;13(2):e0193406. 11. Murray E, Fernandes M, Fazel M, Kennedy SH, Villar J, Stein A. Differential effect of intrauterine growth restriction on childhood neurodevelopment: a systematic review. BJOG: An International Journal of Obstetrics & Gynaecology. 2015 Jul;122(8):1062-72. 12. Fernandes M*, Yang X, Li JY, Cheikh Ismail L. Smoking during pregnancy and vision difficulties in children: a systematic review. Acta Ophthalmologica. 2015 May;93(3):213-23. INTER-NDA e-calculator https://inter-nda.shinyapps.io/inter-nda/ Invited keynote presentations: 1. FinnBrain Congress, Turku, Finland, June 2023 2. Neurodays Conference, University of Aix Marseille, November 2023 Invited keynote speaker, Westminster Education Forum policy conference Child development in the first 1,001 days of life - Family Hubs programme implementation, early skills priorities, parental support and engagement, and creating a joined-up approach (June 2022) 3. British Association for Neonatal Neurodevelopmental Follow Up Study Day (BANNFU) (October 2022) 4. Infants Meet Neuroscience Workshop, University of Regensburg, Regensburg, Germany, funded by the Deutsche Forschungsgemeinschaft (October 2022) 5. The Matthews Fund and International Neuropsychological Society (INS) conference on "Strengthening Capacity for Neuropsychological Assessment in the English-Speaking Caribbean", Grenada, West Indies (2022) International Conferences Organised The RCPCH International Child Health Group Conference on "International Early Child Development: Silent Emergency or Unique Opportunity", November 2021 Capacity Development and International Trainings: 1. Author of the INTER-NDA and INTERGROWTH-21st Neurodevelopment Assessment Training Course (2013-): over 350 assessors trained in 19 countries, approx. 5-7 e-training sessions and 1-2 in person workshops a year. 2. Early child development training workshops (2 to 5 days) for undergraduate and postgraduate researchers: Brazil (2016), Finland (2014), India (2015 and 2018), Kenya (2014), Slovakia (2019), the UK (2012, 2014 and 2020), the USA (2016), and the West Indies (2014, 2016, 2018). Virtual workshops 2-3/year since 2019. Early career researchers: 1. Raquel Lima, research initiation award (2022-23) Medical students: 1. Fee Benz, University of Oxford (2022-4) PhD students: 1. PhD Steering Committee Member, Paula Mustonen and Inka Mattel, University of Turku, Finland (2015 to date) 2. PhD Steering Committee Member, Harsha Behura, KLE University, Bangalore, India (2024-) |
| Start Year | 2012 |
| Description | The INTERGROWTH-21st Project |
| Organisation | University of Oxford |
| Department | Nuffield Department of Obstetrics & Gynaecology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | (1) Design and development of the INTERGROWTH-21st Neurodevelopment Assessment Package, a holistic tool to measure multiple domains of neurodevelopment at 2 years of age in 45 minutes by non-specialists. I designed and supervised the implementation of the piloting of this tool. (2) Design and co-development of software associated with this tool, including the design of the NeuroApp (a tablet based application for data recording and upload with integrated QCs and manuals), and the ERP processing pipeline (together with STARLAB Barcelona) (3) Design of training packages and training of team in 5 project sites (India, Italy, Kenya, the UK and Brazil) (4) Regular QC and management of site teams as NEURODEVELOPMENT LEAD for the Project (5) Development and implementation of Standardization protocol in 4 sites (6) Initiation and management of research collaborations, including IP issues and the founding of the INTER-NDA consortium (a data sharing initiative between adopters of the Package) (7) Development and maintenance of the INTER-NDA website (8) Data analysis and key publication generation (ONGOING) (9) Dissemination of the package and support for adopters through training, consultancy, implementation, data analysis and publications (ONGOING) (10) Presentation of the Package at key meetings including at the WHO, the Bill and Melinda Gates Foundation, and the Carlos Slim Health Foundation. Funding Source: Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator, OMPHI Fellow (previous) |
| Collaborator Contribution | My partners in neurodevelopment have contributed through supporting me, by providing expert advice, in the design and development of the package and in the analysis and writing up of the data. My technical partners in Mexico and Spain have worked with me on the software and hardware aspects of the Package. My site-based collaborators have implemented the package. My partners (and PIs) in Obstetrics and Gynaecology in Oxford were responsible for securing the grant and for the fetal and neonatal growth aspects of the INTERGROWTH-21st Project, whose primary aim was to develop international prescriptive standards of fetal and newborn growth. |
| Impact | Outcomes: Products - (i) The INTERGROWTH-21st Neurodevelopment Package (ii) the INTER-NDA and (iii) The INTER-NDA consortium (see www.inter-nda.com). Publications - 4 background and methodology papers published, 1 accepted by PLoS One (awaiting publication), 2 being amended for re-sbumission following rejection from PLoS One, 3 in process of data being analysed and papers writing up. 5 operation manuals have been published online - see www.inter-nda.com. Adoption - the Package/INTER-NDA has been adopted by 8 independent research studies spanning 9 countries. Recognition - the Package has featured as one of the top 10 candidates for neurodevelopment assessment by the WHO technical consultation on early child development. This collaboration is multi-disciplinary and involves the following disciplines: Paediatrics, Neonatology, Obstetrics and Gynaecology, Child Psychiatry, Epidemiology, Statistics, Clinical Neurosciences, Child Health Publications: 1. Fernandes M*, Villar J, Stein A, Urias ES, Garza C, Victora CG, Barros FC, Bertino E, Purwar M, Carvalho M, Giuliani F. INTERGROWTH-21st Project international INTER-NDA standards for child development at 2 years of age: an international prospective population-based study. BMJ Open. 2020 Jun 1;10(6):e035258. 2. Villar J, Fernandes M, Purwar M, Staines-Urias E, Di Nicola P, Ismail LC, Ochieng R, Barros F, Albernaz E, Victora C, Kunnawar N. Neurodevelopmental milestones and associated behaviours are similar among healthy children across diverse geographical locations. Nature communications. 2019 Jan 30;10(1):1-0. 3. Fernandes M*, Ayede AI & Blackmon K. Addressing racial inequities in neuropsychological assessment requires international prescriptive standards, not demographically adjusted norms. Nat Rev Neurol (2022). https://doi.org/10.1038/s41582-022-00652-7 4. Namburete AIL, Papiez BW, Fernandes M. et al. Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years. Nature (2023). https://doi.org/10.1038/s41586-023-06630-3 5. Fernandes M*, Stein A, Newton CR, Cheikh-Ismail L, Kihara M, Wulff K, de León Quintana E, Aranzeta L, Soria-Frisch A, Acedo J, Ibanez D. The INTERGROWTH-21 st Project Neurodevelopment Package: a novel method for the multi-dimensional assessment of neurodevelopment in pre-school age children. PloS one. 2014 Nov 25;9(11):e113360. 6. Frenquelli R, Ratcliff M, Villar De Onis J, Fernandes M, Barros F, Stein A, Hirst J, Papageorghiou AT, Kennedy SH, Villar J. Complex perinatal syndromes affecting early human growth and development: issues to consider to understand their aetiology and postnatal effects. Frontiers in Neuroscience.:439, 2022. 7. Villar J, Ochieng R, Staines-Urias E, Fernandes M, Ratcliff M, Purwar M, Barros F, Horta B, Ismail LC, Albernaz E, Kunnawar N. Late weaning and maternal closeness, associated with advanced motor and visual maturation, reinforce autonomy in healthy, 2-year-old children. Scientific reports. 2020 Mar 23;10(1):1-27. 8. Fernandes M*. Child developmental follow up in obstetric RCTs: a unique opportunity. BJOG: An International Journal of Obstetrics & Gynaecology. 2020 Mar;127(4):518-. 9. Villar J, Ismail LC, Urias ES, Giuliani F, Ohuma EO, Victora CG, Papageorghiou AT, Altman DG, Garza C, Barros FC, Puglia FFernandes M, Bhutta Z and Kennedy S. The satisfactory growth and development at 2 years of age of the INTERGROWTH-21st Fetal Growth Standards cohort support its appropriateness for constructing international standards. American journal of obstetrics and gynecology. 2018 Feb 1;218(2):S841-54. 10. Murray E, Fernandes M*, Newton CR, Abubakar A, Kennedy SH, Villar J, Stein A. Evaluation of the INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) in 2 year-old children. PLoS One. 2018 Feb 28;13(2):e0193406. 11. Murray E, Fernandes M, Fazel M, Kennedy SH, Villar J, Stein A. Differential effect of intrauterine growth restriction on childhood neurodevelopment: a systematic review. BJOG: An International Journal of Obstetrics & Gynaecology. 2015 Jul;122(8):1062-72. 12. Fernandes M*, Yang X, Li JY, Cheikh Ismail L. Smoking during pregnancy and vision difficulties in children: a systematic review. Acta Ophthalmologica. 2015 May;93(3):213-23. INTER-NDA e-calculator https://inter-nda.shinyapps.io/inter-nda/ Invited keynote presentations: 1. FinnBrain Congress, Turku, Finland, June 2023 2. Neurodays Conference, University of Aix Marseille, November 2023 Invited keynote speaker, Westminster Education Forum policy conference Child development in the first 1,001 days of life - Family Hubs programme implementation, early skills priorities, parental support and engagement, and creating a joined-up approach (June 2022) 3. British Association for Neonatal Neurodevelopmental Follow Up Study Day (BANNFU) (October 2022) 4. Infants Meet Neuroscience Workshop, University of Regensburg, Regensburg, Germany, funded by the Deutsche Forschungsgemeinschaft (October 2022) 5. The Matthews Fund and International Neuropsychological Society (INS) conference on "Strengthening Capacity for Neuropsychological Assessment in the English-Speaking Caribbean", Grenada, West Indies (2022) International Conferences Organised The RCPCH International Child Health Group Conference on "International Early Child Development: Silent Emergency or Unique Opportunity", November 2021 Capacity Development and International Trainings: 1. Author of the INTER-NDA and INTERGROWTH-21st Neurodevelopment Assessment Training Course (2013-): over 350 assessors trained in 19 countries, approx. 5-7 e-training sessions and 1-2 in person workshops a year. 2. Early child development training workshops (2 to 5 days) for undergraduate and postgraduate researchers: Brazil (2016), Finland (2014), India (2015 and 2018), Kenya (2014), Slovakia (2019), the UK (2012, 2014 and 2020), the USA (2016), and the West Indies (2014, 2016, 2018). Virtual workshops 2-3/year since 2019. Early career researchers: 1. Raquel Lima, research initiation award (2022-23) Medical students: 1. Fee Benz, University of Oxford (2022-4) PhD students: 1. PhD Steering Committee Member, Paula Mustonen and Inka Mattel, University of Turku, Finland (2015 to date) 2. PhD Steering Committee Member, Harsha Behura, KLE University, Bangalore, India (2024-) |
| Start Year | 2012 |
| Description | The INTERGROWTH-21st Project |
| Organisation | University of Southampton |
| Department | Paediatrics |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | (1) Design and development of the INTERGROWTH-21st Neurodevelopment Assessment Package, a holistic tool to measure multiple domains of neurodevelopment at 2 years of age in 45 minutes by non-specialists. I designed and supervised the implementation of the piloting of this tool. (2) Design and co-development of software associated with this tool, including the design of the NeuroApp (a tablet based application for data recording and upload with integrated QCs and manuals), and the ERP processing pipeline (together with STARLAB Barcelona) (3) Design of training packages and training of team in 5 project sites (India, Italy, Kenya, the UK and Brazil) (4) Regular QC and management of site teams as NEURODEVELOPMENT LEAD for the Project (5) Development and implementation of Standardization protocol in 4 sites (6) Initiation and management of research collaborations, including IP issues and the founding of the INTER-NDA consortium (a data sharing initiative between adopters of the Package) (7) Development and maintenance of the INTER-NDA website (8) Data analysis and key publication generation (ONGOING) (9) Dissemination of the package and support for adopters through training, consultancy, implementation, data analysis and publications (ONGOING) (10) Presentation of the Package at key meetings including at the WHO, the Bill and Melinda Gates Foundation, and the Carlos Slim Health Foundation. Funding Source: Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator, OMPHI Fellow (previous) |
| Collaborator Contribution | My partners in neurodevelopment have contributed through supporting me, by providing expert advice, in the design and development of the package and in the analysis and writing up of the data. My technical partners in Mexico and Spain have worked with me on the software and hardware aspects of the Package. My site-based collaborators have implemented the package. My partners (and PIs) in Obstetrics and Gynaecology in Oxford were responsible for securing the grant and for the fetal and neonatal growth aspects of the INTERGROWTH-21st Project, whose primary aim was to develop international prescriptive standards of fetal and newborn growth. |
| Impact | Outcomes: Products - (i) The INTERGROWTH-21st Neurodevelopment Package (ii) the INTER-NDA and (iii) The INTER-NDA consortium (see www.inter-nda.com). Publications - 4 background and methodology papers published, 1 accepted by PLoS One (awaiting publication), 2 being amended for re-sbumission following rejection from PLoS One, 3 in process of data being analysed and papers writing up. 5 operation manuals have been published online - see www.inter-nda.com. Adoption - the Package/INTER-NDA has been adopted by 8 independent research studies spanning 9 countries. Recognition - the Package has featured as one of the top 10 candidates for neurodevelopment assessment by the WHO technical consultation on early child development. This collaboration is multi-disciplinary and involves the following disciplines: Paediatrics, Neonatology, Obstetrics and Gynaecology, Child Psychiatry, Epidemiology, Statistics, Clinical Neurosciences, Child Health Publications: 1. Fernandes M*, Villar J, Stein A, Urias ES, Garza C, Victora CG, Barros FC, Bertino E, Purwar M, Carvalho M, Giuliani F. INTERGROWTH-21st Project international INTER-NDA standards for child development at 2 years of age: an international prospective population-based study. BMJ Open. 2020 Jun 1;10(6):e035258. 2. Villar J, Fernandes M, Purwar M, Staines-Urias E, Di Nicola P, Ismail LC, Ochieng R, Barros F, Albernaz E, Victora C, Kunnawar N. Neurodevelopmental milestones and associated behaviours are similar among healthy children across diverse geographical locations. Nature communications. 2019 Jan 30;10(1):1-0. 3. Fernandes M*, Ayede AI & Blackmon K. Addressing racial inequities in neuropsychological assessment requires international prescriptive standards, not demographically adjusted norms. Nat Rev Neurol (2022). https://doi.org/10.1038/s41582-022-00652-7 4. Namburete AIL, Papiez BW, Fernandes M. et al. Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years. Nature (2023). https://doi.org/10.1038/s41586-023-06630-3 5. Fernandes M*, Stein A, Newton CR, Cheikh-Ismail L, Kihara M, Wulff K, de León Quintana E, Aranzeta L, Soria-Frisch A, Acedo J, Ibanez D. The INTERGROWTH-21 st Project Neurodevelopment Package: a novel method for the multi-dimensional assessment of neurodevelopment in pre-school age children. PloS one. 2014 Nov 25;9(11):e113360. 6. Frenquelli R, Ratcliff M, Villar De Onis J, Fernandes M, Barros F, Stein A, Hirst J, Papageorghiou AT, Kennedy SH, Villar J. Complex perinatal syndromes affecting early human growth and development: issues to consider to understand their aetiology and postnatal effects. Frontiers in Neuroscience.:439, 2022. 7. Villar J, Ochieng R, Staines-Urias E, Fernandes M, Ratcliff M, Purwar M, Barros F, Horta B, Ismail LC, Albernaz E, Kunnawar N. Late weaning and maternal closeness, associated with advanced motor and visual maturation, reinforce autonomy in healthy, 2-year-old children. Scientific reports. 2020 Mar 23;10(1):1-27. 8. Fernandes M*. Child developmental follow up in obstetric RCTs: a unique opportunity. BJOG: An International Journal of Obstetrics & Gynaecology. 2020 Mar;127(4):518-. 9. Villar J, Ismail LC, Urias ES, Giuliani F, Ohuma EO, Victora CG, Papageorghiou AT, Altman DG, Garza C, Barros FC, Puglia FFernandes M, Bhutta Z and Kennedy S. The satisfactory growth and development at 2 years of age of the INTERGROWTH-21st Fetal Growth Standards cohort support its appropriateness for constructing international standards. American journal of obstetrics and gynecology. 2018 Feb 1;218(2):S841-54. 10. Murray E, Fernandes M*, Newton CR, Abubakar A, Kennedy SH, Villar J, Stein A. Evaluation of the INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) in 2 year-old children. PLoS One. 2018 Feb 28;13(2):e0193406. 11. Murray E, Fernandes M, Fazel M, Kennedy SH, Villar J, Stein A. Differential effect of intrauterine growth restriction on childhood neurodevelopment: a systematic review. BJOG: An International Journal of Obstetrics & Gynaecology. 2015 Jul;122(8):1062-72. 12. Fernandes M*, Yang X, Li JY, Cheikh Ismail L. Smoking during pregnancy and vision difficulties in children: a systematic review. Acta Ophthalmologica. 2015 May;93(3):213-23. INTER-NDA e-calculator https://inter-nda.shinyapps.io/inter-nda/ Invited keynote presentations: 1. FinnBrain Congress, Turku, Finland, June 2023 2. Neurodays Conference, University of Aix Marseille, November 2023 Invited keynote speaker, Westminster Education Forum policy conference Child development in the first 1,001 days of life - Family Hubs programme implementation, early skills priorities, parental support and engagement, and creating a joined-up approach (June 2022) 3. British Association for Neonatal Neurodevelopmental Follow Up Study Day (BANNFU) (October 2022) 4. Infants Meet Neuroscience Workshop, University of Regensburg, Regensburg, Germany, funded by the Deutsche Forschungsgemeinschaft (October 2022) 5. The Matthews Fund and International Neuropsychological Society (INS) conference on "Strengthening Capacity for Neuropsychological Assessment in the English-Speaking Caribbean", Grenada, West Indies (2022) International Conferences Organised The RCPCH International Child Health Group Conference on "International Early Child Development: Silent Emergency or Unique Opportunity", November 2021 Capacity Development and International Trainings: 1. Author of the INTER-NDA and INTERGROWTH-21st Neurodevelopment Assessment Training Course (2013-): over 350 assessors trained in 19 countries, approx. 5-7 e-training sessions and 1-2 in person workshops a year. 2. Early child development training workshops (2 to 5 days) for undergraduate and postgraduate researchers: Brazil (2016), Finland (2014), India (2015 and 2018), Kenya (2014), Slovakia (2019), the UK (2012, 2014 and 2020), the USA (2016), and the West Indies (2014, 2016, 2018). Virtual workshops 2-3/year since 2019. Early career researchers: 1. Raquel Lima, research initiation award (2022-23) Medical students: 1. Fee Benz, University of Oxford (2022-4) PhD students: 1. PhD Steering Committee Member, Paula Mustonen and Inka Mattel, University of Turku, Finland (2015 to date) 2. PhD Steering Committee Member, Harsha Behura, KLE University, Bangalore, India (2024-) |
| Start Year | 2012 |
| Description | The INTERGROWTH-21st Project |
| Organisation | University of Turin |
| Country | Italy |
| Sector | Academic/University |
| PI Contribution | (1) Design and development of the INTERGROWTH-21st Neurodevelopment Assessment Package, a holistic tool to measure multiple domains of neurodevelopment at 2 years of age in 45 minutes by non-specialists. I designed and supervised the implementation of the piloting of this tool. (2) Design and co-development of software associated with this tool, including the design of the NeuroApp (a tablet based application for data recording and upload with integrated QCs and manuals), and the ERP processing pipeline (together with STARLAB Barcelona) (3) Design of training packages and training of team in 5 project sites (India, Italy, Kenya, the UK and Brazil) (4) Regular QC and management of site teams as NEURODEVELOPMENT LEAD for the Project (5) Development and implementation of Standardization protocol in 4 sites (6) Initiation and management of research collaborations, including IP issues and the founding of the INTER-NDA consortium (a data sharing initiative between adopters of the Package) (7) Development and maintenance of the INTER-NDA website (8) Data analysis and key publication generation (ONGOING) (9) Dissemination of the package and support for adopters through training, consultancy, implementation, data analysis and publications (ONGOING) (10) Presentation of the Package at key meetings including at the WHO, the Bill and Melinda Gates Foundation, and the Carlos Slim Health Foundation. Funding Source: Bill and Melinda Gates Foundation; Professional Status on Project: Neurodevelopment Lead, Collaborator, OMPHI Fellow (previous) |
| Collaborator Contribution | My partners in neurodevelopment have contributed through supporting me, by providing expert advice, in the design and development of the package and in the analysis and writing up of the data. My technical partners in Mexico and Spain have worked with me on the software and hardware aspects of the Package. My site-based collaborators have implemented the package. My partners (and PIs) in Obstetrics and Gynaecology in Oxford were responsible for securing the grant and for the fetal and neonatal growth aspects of the INTERGROWTH-21st Project, whose primary aim was to develop international prescriptive standards of fetal and newborn growth. |
| Impact | Outcomes: Products - (i) The INTERGROWTH-21st Neurodevelopment Package (ii) the INTER-NDA and (iii) The INTER-NDA consortium (see www.inter-nda.com). Publications - 4 background and methodology papers published, 1 accepted by PLoS One (awaiting publication), 2 being amended for re-sbumission following rejection from PLoS One, 3 in process of data being analysed and papers writing up. 5 operation manuals have been published online - see www.inter-nda.com. Adoption - the Package/INTER-NDA has been adopted by 8 independent research studies spanning 9 countries. Recognition - the Package has featured as one of the top 10 candidates for neurodevelopment assessment by the WHO technical consultation on early child development. This collaboration is multi-disciplinary and involves the following disciplines: Paediatrics, Neonatology, Obstetrics and Gynaecology, Child Psychiatry, Epidemiology, Statistics, Clinical Neurosciences, Child Health Publications: 1. Fernandes M*, Villar J, Stein A, Urias ES, Garza C, Victora CG, Barros FC, Bertino E, Purwar M, Carvalho M, Giuliani F. INTERGROWTH-21st Project international INTER-NDA standards for child development at 2 years of age: an international prospective population-based study. BMJ Open. 2020 Jun 1;10(6):e035258. 2. Villar J, Fernandes M, Purwar M, Staines-Urias E, Di Nicola P, Ismail LC, Ochieng R, Barros F, Albernaz E, Victora C, Kunnawar N. Neurodevelopmental milestones and associated behaviours are similar among healthy children across diverse geographical locations. Nature communications. 2019 Jan 30;10(1):1-0. 3. Fernandes M*, Ayede AI & Blackmon K. Addressing racial inequities in neuropsychological assessment requires international prescriptive standards, not demographically adjusted norms. Nat Rev Neurol (2022). https://doi.org/10.1038/s41582-022-00652-7 4. Namburete AIL, Papiez BW, Fernandes M. et al. Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years. Nature (2023). https://doi.org/10.1038/s41586-023-06630-3 5. Fernandes M*, Stein A, Newton CR, Cheikh-Ismail L, Kihara M, Wulff K, de León Quintana E, Aranzeta L, Soria-Frisch A, Acedo J, Ibanez D. The INTERGROWTH-21 st Project Neurodevelopment Package: a novel method for the multi-dimensional assessment of neurodevelopment in pre-school age children. PloS one. 2014 Nov 25;9(11):e113360. 6. Frenquelli R, Ratcliff M, Villar De Onis J, Fernandes M, Barros F, Stein A, Hirst J, Papageorghiou AT, Kennedy SH, Villar J. Complex perinatal syndromes affecting early human growth and development: issues to consider to understand their aetiology and postnatal effects. Frontiers in Neuroscience.:439, 2022. 7. Villar J, Ochieng R, Staines-Urias E, Fernandes M, Ratcliff M, Purwar M, Barros F, Horta B, Ismail LC, Albernaz E, Kunnawar N. Late weaning and maternal closeness, associated with advanced motor and visual maturation, reinforce autonomy in healthy, 2-year-old children. Scientific reports. 2020 Mar 23;10(1):1-27. 8. Fernandes M*. Child developmental follow up in obstetric RCTs: a unique opportunity. BJOG: An International Journal of Obstetrics & Gynaecology. 2020 Mar;127(4):518-. 9. Villar J, Ismail LC, Urias ES, Giuliani F, Ohuma EO, Victora CG, Papageorghiou AT, Altman DG, Garza C, Barros FC, Puglia FFernandes M, Bhutta Z and Kennedy S. The satisfactory growth and development at 2 years of age of the INTERGROWTH-21st Fetal Growth Standards cohort support its appropriateness for constructing international standards. American journal of obstetrics and gynecology. 2018 Feb 1;218(2):S841-54. 10. Murray E, Fernandes M*, Newton CR, Abubakar A, Kennedy SH, Villar J, Stein A. Evaluation of the INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) in 2 year-old children. PLoS One. 2018 Feb 28;13(2):e0193406. 11. Murray E, Fernandes M, Fazel M, Kennedy SH, Villar J, Stein A. Differential effect of intrauterine growth restriction on childhood neurodevelopment: a systematic review. BJOG: An International Journal of Obstetrics & Gynaecology. 2015 Jul;122(8):1062-72. 12. Fernandes M*, Yang X, Li JY, Cheikh Ismail L. Smoking during pregnancy and vision difficulties in children: a systematic review. Acta Ophthalmologica. 2015 May;93(3):213-23. INTER-NDA e-calculator https://inter-nda.shinyapps.io/inter-nda/ Invited keynote presentations: 1. FinnBrain Congress, Turku, Finland, June 2023 2. Neurodays Conference, University of Aix Marseille, November 2023 Invited keynote speaker, Westminster Education Forum policy conference Child development in the first 1,001 days of life - Family Hubs programme implementation, early skills priorities, parental support and engagement, and creating a joined-up approach (June 2022) 3. British Association for Neonatal Neurodevelopmental Follow Up Study Day (BANNFU) (October 2022) 4. Infants Meet Neuroscience Workshop, University of Regensburg, Regensburg, Germany, funded by the Deutsche Forschungsgemeinschaft (October 2022) 5. The Matthews Fund and International Neuropsychological Society (INS) conference on "Strengthening Capacity for Neuropsychological Assessment in the English-Speaking Caribbean", Grenada, West Indies (2022) International Conferences Organised The RCPCH International Child Health Group Conference on "International Early Child Development: Silent Emergency or Unique Opportunity", November 2021 Capacity Development and International Trainings: 1. Author of the INTER-NDA and INTERGROWTH-21st Neurodevelopment Assessment Training Course (2013-): over 350 assessors trained in 19 countries, approx. 5-7 e-training sessions and 1-2 in person workshops a year. 2. Early child development training workshops (2 to 5 days) for undergraduate and postgraduate researchers: Brazil (2016), Finland (2014), India (2015 and 2018), Kenya (2014), Slovakia (2019), the UK (2012, 2014 and 2020), the USA (2016), and the West Indies (2014, 2016, 2018). Virtual workshops 2-3/year since 2019. Early career researchers: 1. Raquel Lima, research initiation award (2022-23) Medical students: 1. Fee Benz, University of Oxford (2022-4) PhD students: 1. PhD Steering Committee Member, Paula Mustonen and Inka Mattel, University of Turku, Finland (2015 to date) 2. PhD Steering Committee Member, Harsha Behura, KLE University, Bangalore, India (2024-) |
| Start Year | 2012 |
| Description | The Omama Project: Profiling Neurodevelopment in Disadvantaged Roma Children |
| Organisation | Cesta Von |
| Country | Slovakia |
| Sector | Charity/Non Profit |
| PI Contribution | Contributions made my myself: 1) Training of the team in the novel 2 year neurodevelopment assessment (the INTER-NDA) of which I am co-author 2) Troubleshooting during implementation of this assessment 3) Designing and formalising the project protocols to include assessments of child growth, health and development - including drafting forms 4) Translation process and cultural customisation process for the neurodevelopment assessment Contributions in the next 1 year: I will be responsible for the analysis of the data generated from this work and for manuscript preparation and submission for publication. Moreover, I, together with my academic supervisor and collaborators plan to apply for a scale up grant for this Project. |
| Collaborator Contribution | Contributions made by my partners: 1) Funding acquisition 2) Set up of the Omama Project 3) Training of omamas 4) On-site implementation and project management 5) Local ethics approval 6) Design of the play-based intervention, its training and implementation 7) Data collection 8) Initial data management 9) Dissemination of results 10) Discussion with policy makers in Slovakia |
| Impact | Current outputs: 1) Research protocol - completed 2) Ethics application - completed 3) Site base training and standardisation of the team - completed during 5 day residential training 4) Database creation - completed 5) e-form creation - completed 6) Implementation of assessments, 61 Roma children assessed from Nov 2019 to date. 7) Presentations in Sept 2022 at Cesta Von Fundraiser event, Bratislava; results presentation at FinnBrain congress (Jun 2023) and Neurodays meeting, University of Aix Marseille (Nov 2023) 8) Abstract publication: Shaw O, Hrica P, Matuskova O, and Fernandes, M. The omama project: supporting the early development of roma children living in poverty. Archives of Disease in Childhood 2022;107:A5. This collaboration is multidisciplinary and includes the following disciplines: 1) Paediatrics 2) Psychology 3) Education 4) Public policy |
| Start Year | 2019 |
| Description | The Omama Project: Profiling Neurodevelopment in Disadvantaged Roma Children |
| Organisation | Research Institute of Child Psychology and Psychopathology |
| Country | Slovakia |
| Sector | Academic/University |
| PI Contribution | Contributions made my myself: 1) Training of the team in the novel 2 year neurodevelopment assessment (the INTER-NDA) of which I am co-author 2) Troubleshooting during implementation of this assessment 3) Designing and formalising the project protocols to include assessments of child growth, health and development - including drafting forms 4) Translation process and cultural customisation process for the neurodevelopment assessment Contributions in the next 1 year: I will be responsible for the analysis of the data generated from this work and for manuscript preparation and submission for publication. Moreover, I, together with my academic supervisor and collaborators plan to apply for a scale up grant for this Project. |
| Collaborator Contribution | Contributions made by my partners: 1) Funding acquisition 2) Set up of the Omama Project 3) Training of omamas 4) On-site implementation and project management 5) Local ethics approval 6) Design of the play-based intervention, its training and implementation 7) Data collection 8) Initial data management 9) Dissemination of results 10) Discussion with policy makers in Slovakia |
| Impact | Current outputs: 1) Research protocol - completed 2) Ethics application - completed 3) Site base training and standardisation of the team - completed during 5 day residential training 4) Database creation - completed 5) e-form creation - completed 6) Implementation of assessments, 61 Roma children assessed from Nov 2019 to date. 7) Presentations in Sept 2022 at Cesta Von Fundraiser event, Bratislava; results presentation at FinnBrain congress (Jun 2023) and Neurodays meeting, University of Aix Marseille (Nov 2023) 8) Abstract publication: Shaw O, Hrica P, Matuskova O, and Fernandes, M. The omama project: supporting the early development of roma children living in poverty. Archives of Disease in Childhood 2022;107:A5. This collaboration is multidisciplinary and includes the following disciplines: 1) Paediatrics 2) Psychology 3) Education 4) Public policy |
| Start Year | 2019 |
| Description | UKRI Action Against Stunting Project |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Training and standardization of hubs in Indonesia, Senegal and India in the 1 and 2 year neurodevelopmental assessments (the OX-NDA and the INTER-NDA) Design of data analysis plan |
| Collaborator Contribution | Project set-up and implementation, securing funding, study design, design of the intervention, growth outcome measurements |
| Impact | Training of Indonesian hub in the OX-NDA and INTER-NDA Training of the Senegal hub in the INTER-NDA Compilation of data analysis plan |
| Start Year | 2020 |
| Description | Women First: Preconception Maternal Nutrition Randomized Controlled Trial |
| Organisation | University of Colorado Denver |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | 1) Assistance in follow-up grant application preparation (2) Training of follow-up lead and project manager in the INTERGROWTH-21st neurodevelopment Package (Vision tests, INTER-NDA and EEG) (3) Assistance of project team in kit assembly (4) Assistance with translation and back translation of questionnaires (5) Site visit to Belgavi, Karnataka, India for standardisation (6) QC through standardisation videos (7) Reliability exercise and analysis of results followed by report generation (8) 3 monthly site phone calls for trouble shooting and support (9) Input into data analysis and manuscript preparation. Funding Source: NIHR & The Bill and Melinda Gates Foundation; Professional Status on Project: Collaborator |
| Collaborator Contribution | Overall study design, ethics, funding, implementation, and management. The objective of this study is to determine the benefits to the offspring of women in poor, food-insecure environments of commencing a daily comprehensive maternal nutrition supplement (with additional balanced calorie/protein supplement for underweight participants) = 3 months prior to conception versus the benefits of commencing the same supplement at 12 weeks gestation and also to compare offspring outcomes with those of a control group which receives no supplement. |
| Impact | Outputs: (i) Effect of pre conceptional maternal nutrition supplement on fetal and infant growth, health, neurodevelopment and epigenome. See https://clinicaltrials.gov/ct2/show/NCT01883193 for more details. This collaboration is multi-discilinary: Paediatrics, Neonatology, Perinatal Medicine, Nutrition. (ii) Fernandes M*, Krebs NF, Westcott J, et al Neurodevelopment, vision and auditory outcomes at age 2 years in offspring of participants in the 'Women First' maternal preconception nutrition randomised controlled trial. Archives of Disease in Childhood (2023) May 4. doi: 10.1136/archdischild-2023-325352 2023 May 4. |
| Start Year | 2016 |
| Description | Women First: Preconception Maternal Nutrition Randomized Controlled Trial |
| Organisation | University of Oxford |
| Department | Nuffield Department of Obstetrics & Gynaecology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | 1) Assistance in follow-up grant application preparation (2) Training of follow-up lead and project manager in the INTERGROWTH-21st neurodevelopment Package (Vision tests, INTER-NDA and EEG) (3) Assistance of project team in kit assembly (4) Assistance with translation and back translation of questionnaires (5) Site visit to Belgavi, Karnataka, India for standardisation (6) QC through standardisation videos (7) Reliability exercise and analysis of results followed by report generation (8) 3 monthly site phone calls for trouble shooting and support (9) Input into data analysis and manuscript preparation. Funding Source: NIHR & The Bill and Melinda Gates Foundation; Professional Status on Project: Collaborator |
| Collaborator Contribution | Overall study design, ethics, funding, implementation, and management. The objective of this study is to determine the benefits to the offspring of women in poor, food-insecure environments of commencing a daily comprehensive maternal nutrition supplement (with additional balanced calorie/protein supplement for underweight participants) = 3 months prior to conception versus the benefits of commencing the same supplement at 12 weeks gestation and also to compare offspring outcomes with those of a control group which receives no supplement. |
| Impact | Outputs: (i) Effect of pre conceptional maternal nutrition supplement on fetal and infant growth, health, neurodevelopment and epigenome. See https://clinicaltrials.gov/ct2/show/NCT01883193 for more details. This collaboration is multi-discilinary: Paediatrics, Neonatology, Perinatal Medicine, Nutrition. (ii) Fernandes M*, Krebs NF, Westcott J, et al Neurodevelopment, vision and auditory outcomes at age 2 years in offspring of participants in the 'Women First' maternal preconception nutrition randomised controlled trial. Archives of Disease in Childhood (2023) May 4. doi: 10.1136/archdischild-2023-325352 2023 May 4. |
| Start Year | 2016 |
| Description | Women First: Preconception Maternal Nutrition Randomized Controlled Trial |
| Organisation | University of Southampton |
| Department | Paediatrics |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | 1) Assistance in follow-up grant application preparation (2) Training of follow-up lead and project manager in the INTERGROWTH-21st neurodevelopment Package (Vision tests, INTER-NDA and EEG) (3) Assistance of project team in kit assembly (4) Assistance with translation and back translation of questionnaires (5) Site visit to Belgavi, Karnataka, India for standardisation (6) QC through standardisation videos (7) Reliability exercise and analysis of results followed by report generation (8) 3 monthly site phone calls for trouble shooting and support (9) Input into data analysis and manuscript preparation. Funding Source: NIHR & The Bill and Melinda Gates Foundation; Professional Status on Project: Collaborator |
| Collaborator Contribution | Overall study design, ethics, funding, implementation, and management. The objective of this study is to determine the benefits to the offspring of women in poor, food-insecure environments of commencing a daily comprehensive maternal nutrition supplement (with additional balanced calorie/protein supplement for underweight participants) = 3 months prior to conception versus the benefits of commencing the same supplement at 12 weeks gestation and also to compare offspring outcomes with those of a control group which receives no supplement. |
| Impact | Outputs: (i) Effect of pre conceptional maternal nutrition supplement on fetal and infant growth, health, neurodevelopment and epigenome. See https://clinicaltrials.gov/ct2/show/NCT01883193 for more details. This collaboration is multi-discilinary: Paediatrics, Neonatology, Perinatal Medicine, Nutrition. (ii) Fernandes M*, Krebs NF, Westcott J, et al Neurodevelopment, vision and auditory outcomes at age 2 years in offspring of participants in the 'Women First' maternal preconception nutrition randomised controlled trial. Archives of Disease in Childhood (2023) May 4. doi: 10.1136/archdischild-2023-325352 2023 May 4. |
| Start Year | 2016 |
| Title | Neo-NBA |
| Description | Novel, standardized, mixed methdology neurobehavioual assessment for newborn 0-28 days old |
| IP Reference | |
| Protection | Trade Mark |
| Year Protection Granted | 2022 |
| Licensed | Yes |
| Impact | Validation study ongoing in Turin Italy |
| Title | Tele-INTER-NDA |
| Description | Virtual INTER-NDA assessment |
| IP Reference | |
| Protection | Trade Mark |
| Year Protection Granted | 2022 |
| Licensed | No |
| Impact | Virtual standardised neurodevelopment assessment for 2 year olds developed for use during the OCVID-19 pandemic when face to face assessments were not possible |
| Title | INTER-NDA E-calculator |
| Description | A web-app for the easy recording of INTER-NDA item scores, with automated calculation of standardized domain scores, their interpretation and rapid identification of children at risk of severe cognitive, language, fine motor and/or gross motor delay; and behavioural problems, at age 2 years. Open source, very user-friendly, web-based (no download required), accessible on multiple devices with need for special software/settings, results downloadable in PDF format, GDPR compliant - no data stored, no personal information collected Limitation: available in English only, suitable only for individual assessments - not suitable for research study group calculations. I led the design of this app and oversaw its coding and development by my colleague Dr Young I led piloting and testing of the app and its international launch and dissemination. |
| Type Of Technology | Webtool/Application |
| Year Produced | 2023 |
| Impact | Multiple international users including clinical and research staff Being applied in the NIHR-funded INTER-NEO study for the follow-up of high risk NICU graduates at University Hospitals Southampton NHS Foundation Trust |
| URL | https://inter-nda.shinyapps.io/inter-nda/ |
| Title | OX-NDA E-form |
| Description | E-form for data entry and data download of OX-NDA assessments |
| Type Of Technology | Webtool/Application |
| Year Produced | 2021 |
| Impact | Ease of data entry and download with integrated manual and QCs preventing missing and multiple entries Automated dataset creation |
| Description | 1.5 hour invited lecture at the University of Sharjah, Sharjah, UAE on 1 March 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | I delivered a 1.5 hour lecture to the MSc Maternal and Child health students at the University of Sharjah, Sharjah, UAE on 1 Marcha 2023 on the topic of "The importance of health, growth and development in the first 1000 days of life". This resulted in about 25 minutes of healthy discussion with the audience who reported changes in their knowledge and understanding and much new interest in early life research. |
| Year(s) Of Engagement Activity | 2023 |
| Description | 2 day visit to early life programme |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | 2 day visit to early life programme funded by the Frank Field Education Trust at Ellesmere Port |
| Year(s) Of Engagement Activity | 2022 |
| Description | Capacity Building in the majority world - promoting psychological science in LMICs |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 1. Invited presentation on "Capacity building [in early child development] in the majority world: From lessons to ideas" talking about my experience in building "neuro-hubs" internationally and next steps 2. Summary of my research in this area 3. Linking with the workshop to discuss barriers and solutions, and how to best engage stakeholders 4. Drafting concept paper with atendees |
| Year(s) Of Engagement Activity | 2023 |
| Description | Expert advisor in child development to WHO GSED goup |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Project Expert Group advisory meeting for WHO Global Scales of Early Development hosted by the WHO in Dec 22, next meeting Jan 22. Approx. 35 attendees from a range of disciplines and organisations including UNICEF and the World Bank |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited keynote lecture at Westminster Education Forum policy conference on Child development in the first 1,001 days of life - Family Hubs programme implementation, early skills priorities, parental support and engagement, and creating a joined-up approach |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Invited keynote lecture at Westminster Education Forum policy conference on "Child development in the first 1,001 days of life - Family Hubs programme implementation, early skills priorities, parental support and engagement, and creating a joined-up approach" on the topic of "Adopting a whole-child approach to early child development". About 200 persons attended this virtual lecture. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited keynote lecture at the British Association for Neonatal Neurodevelopmental Follow Up Study Day (BANNFU) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited keynote lecture at the British Association for Neonatal Neurodevelopmental Follow Up Study Day (BANNFU) on the topic of "Measuring early child development on the INTER-NDA and its standards" |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited keynote lecture at the NeuroDays 2023 conference entitled, "The Brain Chronicles: A journey throughout the brain's lifetime" on November 16, organised by the University of Aix Marseille. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | I delivered an inited keynote lecture entitled "Fulfilling their Developmental Potential: Lessons on Early Child Development Across Populations & Geographies" during the NeuroDays 2023 conference entitled, "The Brain Chronicles: A journey throughout the brain's life&me" on November 16, organised by the University of Aix Marseille. This 35 minute presentation was followed by over 30 minutes of lively Q&A with a very engaged audience, and followed up by many emails of appreciation and requests for further information about my research and tools, and inquiries about internships / opportunities with my research team. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Invited keynote presentation at Infants Meet Neuroscience Workshop at the University of Regensburg, Germany |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited keynote presentation at Infants Meet Neuroscience Workshop at the University of Regensburg, Germany on the topic of "Adopting a Whole Child Approach to Early Child Development". This was a closed, expert neuroscience workshop focussing specifically on experts in infant neuroscience from Europe and the UK. This was funded by the German Research Foundation (Deutsche Forschungsgemeinschaft). |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited keynote presentation at Matthews Fund workshop on "Strengthening Capacity for Neuropsychological Assessment in the English-Speaking Caribbean" hosted by the INS and WINDREF |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited keynote presentation at Matthews Fund workshop on "Strengthening Capacity for Neuropsychological Assessment in the English-Speaking Caribbean" hosted by the INS and WINDREF, on the topic of "Developmentally, Are Children Across the World More Similar Than They Are Different? Using the First International Early Child Development Standards to Quantify Differences in Neuro-cognitive Outcomes Between Children from Diverse Populations": about 100 persons attended this hybrid lecture |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited keynote presentation at the 2nd FinnBrain International Congress on Prenatal and Early Life Stress |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited key note presentation at international conference attended to by apporximately 200 researchers, clinicians, funders, and parent groups from across the world on the topic of "Associations between early life stress and child development: Biologically determined or environmentally derived?" which sparked questions and discussion afterwards and there were requests for use of my reserach outputs (neurodevelopmental assessments) in other settings, and new collaborations which I am currently following up on. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://sites.utu.fi/finnbraincongress/ |
| Description | Invited keynote presentation at the Speech and Language Therapy Promoting Communication in the Early Years CEN Day on November 22 2023, organised by the Promoting Communication in the Early Years Clinical Excellence Network. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited keynote presentation entitled "Adopting a Whole Child Approach to Early Child Development: Lessons Across Populations & Geographies" featuring my research and outreach work, and examples of my research's real-world applications internationally in promoting early child development scalably and sustainably using communities and families as drivers of change. This one hour talk sparked over 30 minutes of lively Q&A from the audience and also resulted in a number of participants contacting me via email to ask for my publications and links to my tools, and one contacting me to volunteer her services in helping with my research and outreach programmes. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Invited keynote talk at workshop titled "Use of Psychological and Neuropsychological Test Norms with Diverse Populations: Issues, Best Practices, and Future Trends" at virtual CE conference jointly sponsored by the Massachusetts Psychological Association and the Massachusetts Neuropsychological Society. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | This workshop focussesd on a discussion of the issues and best practices in the use of psychological and neuropsychological test norms with geographically, ethnically and culturally diverse populations of children and adults, with the aim of discussing current practices and future trends with practical implications on the measurement of neuropsychological outcomes in clinical practice and in research. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Invited presentation at CESTA VON annual fundraiser at Slovakia, Sept 22 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | Invited keynote presentation on results of the Omama Project on improving child development outcomes at the CESTA VON annual fundraiser event, Sept 2022. Approx. 75-90 people attended |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://cestavon.sk/en/home |
| Description | Invited talk on fellowship applications for clinical academics |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | This was a workshop organised by the Institute of Developmental and Regenerative Medicine at the University of Oxford, titled "Fellowship Applications: Lessons Learned from Recent Successes" where I was invited to speak about my experience and to share my learning about successful obtaining a clinical academic fellowship. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Joint press release with Oxford University and Cesta Von, titled "Early support for children living in marginalised communities can improve developmental outcomes" featuring results of the Omama project |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Joint press release with Oxford University and Cesta Von, titled "Early support for children living in marginalised communities can improve developmental outcomes" featuring results of the Omama project. The press release presented the results of the Omama study, undertaken by Dr Michelle Fernandes and the F1000 research group, focused on Roma children living in poor communities in Eastern Slovakia who are subjected to the "triple threat" of poverty, stunting and early developmental delays, with many prevented from achieving their full developmental potential by age five years. The study compared neurodevelopmental outcomes at age two years between Roma children receiving a community-based early child development (ECD) intervention, and age and sex-matched Roma and non-Roma children who did not receive the intervention. Results of the comparison show that the interventions significantly improved the neurodevelopmental outcomes of children at age two years, including their cognitive, language, and motor skills without directly intervening on nutritional and poverty status. The Roma are Europe's largest ethnic minority with high rates of neurodisability, malnutrition and poverty reported in preschoolers. The interventions delivered in the study were multi-modal and delivered by trained Roma women (termed Omamas which is Slovak for grandmothers) to Roma children aged three weeks to 24 months. They were delivered in weekly, 1-hour sessions in the child's home in the presence of the primary caregiver who was trained in the activities and encouraged to continue these during the week. The Omamas received a pre-defined schedule of age-appropriate activities via the INTER-NDA, a mobile-device-based application which included aspects of kangaroo mother care, infant massage, play, reading, music and responsive caregiving. The assessments showed that where the Omamas intervened, children were 88% less likely to be delayed in their neurodevelopment and demonstrated significantly better cognitive, language, and motor skills, compared to their peers living in the same communities who had not received the same stimulation. |
| Year(s) Of Engagement Activity | 2025 |
| URL | https://www.ox.ac.uk/news/2025-01-30-early-support-children-living-marginalised-communities-can-impr... |
| Description | Led the organisation and execution of the RCPCH International Child Health Group Conference on the theme of international early child development |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The first 1000 days of a child's life are the most crucial period of brain development. Early child development has been acknowledged as the single-most important predictor of human capital but has lagged behind growth, nutrition and infectious diseases on the global child health agenda. An estimated 1 in 5 children globally are at risk of not achieving their developmental potential by 5 years of age due to poverty and stunting alone. Up to 80% of these delays are preventable through early interventions if administered during the first 2 years of life. The 2021 International Child Health Group Winter Conference on the theme of "Early Child Development: Silent Emergency or Unique Opportunity" brought together the latest early child development research from across the world to answer important questions relating to risk and resilience; screening and intervention; race and ethnicity and the impact of societies in flux on early child development as we know it. The day featured plenary talks from world leading experts in the field with the opening keynote by the officer in charge of ECD from UNICEF and the final keynote by the WHO's Head of the Brain Unit. The conference includes a choice of two of 11 small group workshops. The conference had over 250 registered attendees from 43 countries and was hosted using a hybrid model i.e. virtually with in-person socially-distanced hubs in Nigeria and Slovakia. The conference was accredited for CPD by the RCPCH. Registration fees were waived for all attendees from LMICs and for students from HICs and LMICs. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://internationalchildrenshealthgroup.eventscase.com/EN/ICHGWinterMeeting2021 |
| Description | Press release by Oxford University titled "Clinical Lecturer in Paediatrics selected as finalist for the MRC Impact Prize 2023: Early Career Impact" |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | This press release by Oxford University features my nomination as a finalist for the MRC Impact Prize 2023: Early Career Impact in recognition of my achievements as a pioneer in early brain science and international early child development research. My submission was titled: The INTER-NDA: An open-source international toolkit for the simplified, rapid identification of children with developmental delay at age 2 years. It encompasses my research with the INTERGROWTH-21st Project, the INTERBIO-21st study and multi-national collaborators in leading the development and dissemination of a novel, low-cost, international toolkit for the simplified and rapid identification of young children at risk of developmental delay by non-specialist assessors. The toolkit includes a standardised, developmental assessment (the INTERGROWTH-21st Neurodevelopment Assessment, (INTER-NDA); www.inter-nda.com); its automated, web-based calculator; a bespoke educational programme and a checklist to ensure its correct implementation in research, clinical practice, and health programmes globally. The nomination was also for my leadership in constructing the first international, prescriptive standards of early child development and her research findings from the INTERGROWTH-21st project showing that that healthy, well-nourished children across diverse geographies, populations and cultures achieve very similar neurodevelopmental outcomes at age 2 if their basic health, nutritional and socio-environmental needs during early life are met (Villar, Fernandes, et al. Nature Communications. 2019). This fundamental biological finding stimulated important debate about the scientific and ethical rationale behind racially-adjusted norms for neurocognitive outcomes (Fernandes, Ayede and Blackmon, Nature Reviews Neurology 2022). The nomination also focuses on my role in training over 300 international assessors from 19 countries in the INTER-NDA toolkit and, together with regional collaborators, in formalising capacity development units in early developmental screening in the Caribbean, South India, Nigeria and Slovakia. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.paediatrics.ox.ac.uk/news/clinical-lecturer-in-paediatrics-selected-as-finalist-for-the-... |
| Description | Scientific advisor to RCPCH Global Links Lebanon Project |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Supporters |
| Results and Impact | Ongoing meetings with RCPCH Global Links Lebanon and Medical Aid for Palestinians Teams re integration of developmental screening programme in UNWRA's refugee camp healthcare programmes in Lebanon - activities suspended in 2024 in view of conflict in Gaza |
| Year(s) Of Engagement Activity | 2022,2023,2024 |