Acquisition and Selection of Antibiotic Resistance in Companion and Farmed Animals and Implications for Transmission to Humans

Lead Research Organisation: University of Bristol
Department Name: Cellular and Molecular Medicine

Abstract

Without antimicrobial drugs, the risk of bacterial infection would render many common medical procedures too dangerous to contemplate because of the risk of infections caused by "opportunistic bacteria". They can live on the patient's skin, or in their intestines, and infection occurs when bacteria get into parts of the body that are normally sterile. A perfect example is urinary tract infection (UTI) caused by faecal bacteria. E. coli is particularly abundant in human faeces so is perfectly placed to cause opportunistic infections. It is one of the most common causes of healthcare pneumonia, surgical site infection, bloodstream infection and UTI in the UK. In order to prevent against and treat opportunistic infections, patients are given antimicrobials.

Almost all antimicrobials are "antibiotics", which means they are derived from natural chemicals produced by microbes found in the environment. Natural antibiotics have been present in the environment for millions of years, and so bacteria living in their presence have had time to evolve mechanisms that can resist their actions, encoded by "resistance genes". Opportunistic bacteria like E. coli can randomly acquire these pre-evolved resistance genes and in a single step, they become insusceptible to a particular antimicrobial. If that insusceptible E. coli colonises a person and then causes an opportunistic infection, the infection will not be treatable with that particular antimicrobial. We refer to this as "antimicrobial resistance" (AMR); however AMR bacteria don't just resist clinical antimicrobial therapy, they beat it.

Animals also carry an abundance of E. coli in their intestines and are frequently treated with antimicrobials. This can select for the acquisition of AMR E. coli which can then be passed on to another animals, directly, or via contamination of the environment with faeces. Theoretically, the AMR E. coli could also be passed on to people, and there is much debate about whether such "zoonotic transmission" happens to any significant degree. This is an important debate because it has led to calls from some to dramatically reduce the amount of antimicrobials that are given to animals with the view that it will reduce the level of AMR in animals, and so the possibility of zoonotic transmission to people. But the potential impact on welfare and food production means this should only be done if there is evidence that it will work.

In this project we will identify what drives acquisition of AMR in animals using E. coli as the exemplar bacterium and dairy cows and dogs as exemplar farmed and companion animals. We will test whether AMR bacteria encountered by an animal as it interacts with the environment influence the AMR profile in its faeces, and/or whether early life antimicrobial use plays a part in selection of AMR bacteria in animals. We will also test whether reducing antimicrobial use in dairy cows actually does reduce AMR in the near-farm environment that is contaminated with their faeces. We will test whether exercising in these contaminated near-farm environments influences the abundance of AMR bacteria in dogs, and whether there is any evidence of direct acquisition of AMR E. coli by dogs from near-farm environments, which might be brought into the home.

Finally, we will investigate whether AMR abundance in human UTI E. coli reduces as antimicrobial drug prescribing reduces in primary care; whether living close to a farm affects AMR abundance in UTI E. coli; whether there is direct evidence for E. coli carried by dogs or found in near-farm environments contaminated by cattle faeces also causing UTIs in humans.

These interlaced studies will provide much needed data about the management changes that might reduce AMR in animals and in humans, and are designed to address the fundamental question of whether zoonotic transmission is particularly significant as a driver of AMR in people relative to antimicrobial drug use by doctors.

Planned Impact

INDUSTRY
This project addresses the impact that the Farming and Veterinary Medicine industries might have on human health through animal-mediated contamination of publically accessible land with AMR bacteria, and because zoonosis is a recognised health and safety risk for farmers and veterinarians. Understanding risk factors for acquisition of AMR in farmed and companion animals and possible ways to mitigate them will help these industries react to growing public concern about AMR and possible legislation in an informed way. Directly involving businesses from these sectors in our project will allow them to advocate for our findings in their own industries. For example, provision of first-hand evidence on the positive effect of reducing antibiotic use on AMR levels on the farms in our study may stimulate a peer-led process to encourage other businesses to consider how to reduce levels further. Limiting the rise of AMR will make farming in the UK more productive (via less untreatable disease) and more economically successful, and will provide a model for tackling AMR elsewhere in the world.

REGULATORY BODIES
The Veterinary Medicines Directorate (VMD) has confirmed its interest in this project, and we have had meetings with the VMD AMR Surveillance Team about our work. VMD is responsible for channelling EU regulations for reducing AMR in the veterinary controlled environment. VMD recognise, however, that there are significant knowledge gaps, and this study will address three of these: how antibiotic use selects for resistance; current AMR levels in healthy animals and in the environment; what might be done to reduce these levels. Other Defra executive agencies such as Natural England are likely to be interested in our research as it pertains to footpaths and we have included significant Public Health England involvement in the project, so our findings can feed back to provide public information about the importance of reducing exposure to AMR in the environment. Local authorities also have responsibility for establishing areas in which dog faeces must be collected and enforcing bylaws, so the may also be interested.

THIRD SECTOR
Approximately 130,000 dogs were estimated to enter rescue centres run by animal charities in 2009. Dogs mixing in these environments may be an important aspect of AMR transmission, impacting on the management of such centres. Charities also place dogs into new homes (e.g. Dogs Trust re-homed almost 15,000 dogs last year), and information on risk to human health from this project will help inform the best policy. Walking groups including those convened through the Ramblers' Association and the U3A will be interested in the findings of this study. U3A members are likely to be aware through personal experience of the rise of AMR and its role in healthcare-associated and opportunistic community infections, and may benefit from any simple risk mitigation strategies that our findings might suggest.

WIDER PUBLIC
According to Natural England, >800 million visits to the natural environment were made by people in England and Wales between March and May 2015. An estimated 10.5 million dogs are kept as companion animals in the UK, and are often regarded as members of the family. If zoonotic transmission of AMR from the environment, directly or via companion animals, is a significant health risk, then our research promises considerable benefits for the health and wellbeing of the UK population by attempting to identify risk factors for acquisition of AMR in farmed and companion animals, but also by simply highlighting such a risk. For instance, basic hand hygiene is a simple intervention that might be all that is required to have a considerable effect on decreasing the transmission of AMR pathogens.

Publications

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Hay AD (2019) Antibiotic prescribing in primary care. in BMJ (Clinical research ed.)

 
Description We have surveyed bacteria that cause urinary tract infections in bacteria from people presenting at GP practices in the Bristol, North Somerset and South Gloucestershire CCG. We have identified that these bacteria are infrequently resistant to key antibiotics - the third generation cephalosporins - but that resistance does occur. We have identified the mechanisms of resistance in these bacteria and have characterised their relationships between each other. This will form the basis for future work in this ongoing project.

We have confirmed that antibiotic use in humans in primary care is reducing and that this has driven down the prevalence of antibiotic resistant bacteria causing urinary tract infections in our region, but not in all cases. We have identified paradoxical effects were antibiotic use has reduced, but resistance to that antibiotic has increased. We are focussing our attention on hospital use of antibiotics in order to try and explain this.

We have established novel methods to quantify the amount of antibiotics used in dairy farming, and these methods will be used for this ongoing project.

We have surveyed bacteria found in faecal samples from 53 dairy farms in the South West of England. We have quantified the prevalence of bacteria resistant to five important antibiotics. Some are very common, others, particularly the critically important antibiotics, very rare. We have identified the mechanisms of critically important antibiotic resistance, and have clearly demonstrated farm to farm transmission of resistant bacteria. We have compared the bacteria from farms with those found in people living in the same region, but have identified very little overlap, suggesting that humans pass resistant bacteria between each other, and very rarely acquire resistant bacteria that cause urinary tract infections from farms.

We have identified the factors that influence the prevalence of antibiotic resistant bacteria on dairy farms in our study. The key risk factor is ambient temperature - in warmer months resistant bacteria are more common, in cold months they are almost nonexistant. We have also identified that calves carry more antibiotic resistant bacteria than adult cows, and will now proceed to try to understand why. We have identified a few farm management practice drivers of antibiotic resistance, including some instances where antibiotic use drives up resistance, and these will form the bases of policy changes aimed at reducing antibiotic resistance in dairy farms.
Exploitation Route A baseline survey of mechanisms of antibiotic resistance in the community (human and farms) is important because it allows changes over time to be established, for example, if antibiotic use changes or there are changes to the population. The survey can also be used to start predicting which antibiotics are best given for the infections caused by these bacteria in the local region studied. We are potentially above to track transmission of resistant bacteria, which will inform interventions aimed at reducing transmission.
Sectors Agriculture, Food and Drink,Communities and Social Services/Policy,Healthcare

 
Description Contribution to POST-PN-0588 "Reducing UK Antibiotic Use in Animals"
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
URL https://researchbriefings.parliament.uk/ResearchBriefing/Summary/POST-PN-0588
 
Description Contribution to POST-PN-0595 "Reservoirs of Antimicrobial Resistance"
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
URL https://researchbriefings.parliament.uk/ResearchBriefing/Summary/POST-PN-0595#fullreport
 
Description Guideline Development Group for the NICE 'Managing Common Infections' Guideline - Alastair Hay
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
URL https://www.nice.org.uk/guidance/indevelopment/gid-ng10050/documents
 
Description RUMA Scientific Committee
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Diagnostic innovation and livestock (DIAL): towards more effective and sustainable applications of antibiotics in livestock farming
Amount £1,399,619 (GBP)
Funding ID ES/P008194/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 07/2017 
End 06/2021
 
Description FARMS-SAFE: Future-proofing Antibacterial resistance Risk Management Surveillance and Stewardship in the Argentinian Farming Environment
Amount £989,327 (GBP)
Funding ID BB/T004592/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 07/2019 
End 05/2022
 
Description Improving empiric antibiotic prescribing by applying a Bayesian decision theory approach to phenotypic and genomic resistance data.
Amount £223,521 (GBP)
Funding ID MR/T005408/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2020 
End 12/2022
 
Description One Health Drivers of Antibacterial Resistance in Thailand
Amount £2,919,177 (GBP)
Funding ID MR/S004769/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 05/2018 
End 04/2021
 
Description One Health Drivers of Antibacterial Resistance in Thailand
Amount £70,825 (GBP)
Funding ID MR/R014922/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 11/2017 
End 04/2018
 
Description The Medical Research Foundation National PhD Training Programme in Antimicrobial Resistance Research
Amount £2,838,607 (GBP)
Funding ID MRF-145-0004-TPG-AVISO 
Organisation Medical Research Council (MRC) 
Department Medical Research Foundation
Sector Charity/Non Profit
Country United Kingdom
Start 10/2017 
End 01/2023
 
Description Collaboration with Nora Mestorino, University of La Plata 
Organisation University of La Plata
Country Argentina 
Sector Academic/University 
PI Contribution We have developed a collaboration to test AMR in bacteria from farms in Argentina, which will be isolated by Dr Mestorino, and analysed by us. This has also resulted in a BBSRC grant, funded to extend this work from the preliminary.
Collaborator Contribution They have provided bacterial isolates for our analysis
Impact BBSRC grant awarded.
Start Year 2019
 
Description (Bruce and Reyher) Food Industry Initiative on Antimicrobials R&D group, London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Attending meeting
Year(s) Of Engagement Activity 2019
 
Description (Reyher and Buller) Fieldwork, presentations and meetings in Bangkok, Thailand 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Study participants or study members
Results and Impact Presentation of DIAL research and engagement with academic and research community through MRC funded OH-DART project
Year(s) Of Engagement Activity 2018
 
Description (Reyher) DARC, Stonleigh 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Attendance at Meeting as member of DIAL project (and other projects)
Year(s) Of Engagement Activity 2018
 
Description (Reyher) Food Industry Initiative on Antimicrobials R&D group, London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Presentation of DIAL project and other engaged AMR research
Year(s) Of Engagement Activity 2018
 
Description (Reyher) RSM AMR Meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Attendance and presentation of DIAL project and related research
Year(s) Of Engagement Activity 2018
 
Description (Reyher) RUMA, Stoneleigh 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Attended meeting as member of DIAL team (and other research teams)
Year(s) Of Engagement Activity 2018
 
Description (Reyher) SEFARI AMR conference, Glasgow 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Presentation as a member of DIAL Research team (and other teams)
Year(s) Of Engagement Activity 2018
 
Description (Reyher) UK AMR Strategy Stakeholder Forum, Surrey 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Attended as member of Forum and as member of DIAL research team (and other research teams)
Year(s) Of Engagement Activity 2018
 
Description (Reyher) UK-Israel AMR workshop, Birmingham 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Attended meeting as member of DIAL research team (and others)
Year(s) Of Engagement Activity 2018
 
Description 2019/20 OH-STAR Farmers Meetings 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact We presented the OH-STAR Dairy AMR project findings to the farmers who had participated in the project. They showed considerable interest in the results, and many requested to be involved in future projects. Some stated that they would modify their practice based on our findings, in an attempt to reduce AMR.
Year(s) Of Engagement Activity 2020
 
Description AMR Force (Reyher) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Exploration of collaboration opportunities with VMD, Langford
Year(s) Of Engagement Activity 2019,2020
 
Description AMR talk at Monkton Coombe School 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Matthew Avison visited Monkton Coombe School to give a talk on AMR entitled 'Superbugs: Is Resistance Futile?' Pupils came up with imaginative questions and the school reported increased interest in the subject within the school population.
Year(s) Of Engagement Activity 2017
 
Description Access to Bristol schools event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact About 50 motivated college students came to Bristol from the region to get a taster for microbiology. Matthew gave a talked entitled Superbugs: Is Resistance Futile? Some students reported it had given them an interest in going into the field of microbiology.
Year(s) Of Engagement Activity 2016
 
Description Agriculture and Horticulture Development Board Mastitis Control Plan Management Group meeting (Reyher) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Mastitis Control Plan Management Group Committee meeting in Wells
Year(s) Of Engagement Activity 2019
 
Description Alastair Hay - University of Washington School of Medicine Research Seminar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Alastair was invited to speak at the University of Washington to present "Improving Use of Antibiotics for Children in Primary Care - International Research from the United Kingdom". Faculty staff and junior doctors discussed how educational practitioners should be educated in policy and feedback was that lessons Alastair has learnt will be useful for our US counterparts.
Year(s) Of Engagement Activity 2016
URL https://depts.washington.edu/fammed/blog/dfm-research-seminar-improving-use-of-antibiotics-for-child...
 
Description American and Canadian High School visit to UoB 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact Pupils from American and Canadian High Schools attended a day at UoB. Matthew gave a talk entitled Superbugs: Is Resistance Futile? Pupils had many challenging questions and some said afterwards that they had no idea you could select for an antibiotic resistance gene by using another antimicrobial like ammonium compounds.
Year(s) Of Engagement Activity 2016
 
Description Attributed quotes for Observer/Guardian article "'Antibiotic apocalypse': doctors sound alarm over drug resistance" 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Matthew Avison was interviewed about colistin resistance emergence in humans and the folly of expecting to re-use a drug so heavily used in veterinary medicine. The article was heavily discussed on social media, and has been cited to influence policy around licencing of antimicrobial products.
Year(s) Of Engagement Activity 2017
URL https://www.theguardian.com/society/2017/oct/08/world-faces-antibiotic-apocalypse-says-chief-medical...
 
Description Award Press Release - University of Bristol 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Press release about the award and its aims. Several news outlets picked this up.
Year(s) Of Engagement Activity 2016
URL http://www.bristol.ac.uk/news/2016/june/animals-humans-amr.html
 
Description BBC Points West TV interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Dr Kristen Reyher from Bristol Vet School was interviewed about AMR research on BBC Points West (5 mins) (local television prime time news)
Year(s) Of Engagement Activity 2017
 
Description BBC Radio 4 Farming Today interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Kristen Ryher was on BBC Radio 4 Farming Today discussing AMR research and particularly the link between medicines usage and AMR.
Year(s) Of Engagement Activity 2017
 
Description BBC Radio 4 Inside Science Interview 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Matthew Avison was invited to take part in a 10 minute interview/discussion about the impact of antimicrobial usage in farming on antimicrobial resistance in human medicine, and the way UK farmers have led the way in antibiotic usage reduction. The piece was broadcast and podcasted, and led to a significant secondary media and social media interest.
Year(s) Of Engagement Activity 2017
URL https://www.bbc.co.uk/programmes/b0977v58
 
Description BBC Radio Bristol Interview 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Matthew Avison had 30 minute interview with Steve Yabsley on BBC Radio Bristol about AMR research project. Stimulated discussion via phone in comment from members of the public
Year(s) Of Engagement Activity 2016
URL http://www.bbc.co.uk/programmes/p04dxl57
 
Description BBC Radio Bristol about Puppy AMR Project 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Matthew Avison was interviewed by Emma Britton on BBC Radio Bristol for 10 mins about our project investigating risk factors for the carriage of AMR in puppies. The main purpose of the interview was to advertise our recruitment of puppies and their owners. There was a tremendous response and more than 250 puppies were recruited
Year(s) Of Engagement Activity 2017
 
Description BridgeBridge AMR Schools Outreach Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact 160 students from the region came to a cross-faculty schools conference recently for post-16 biology and chemistry students held within the School of Chemistry to examine why AMR is an escalating global threat. Matthew opened the conference and gave a talk entitled 'Superbugs: Is Resistance Futile?'
Year(s) Of Engagement Activity 2016
URL http://www.bristol.ac.uk/news/2016/december/schools-conference-amr.html
 
Description Bristol AMR/Colston Research Symposium. The Antibiotic Age: The End or a New Beginning? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Gave a speech entitled: 'Antibiotics Anonymous - Antimicrobial stewardship and voluntary reduction across the UK livestock sectors' and networked with conference attendees
Year(s) Of Engagement Activity 2019
URL https://www.bristol.ac.uk/amr/events/2019/colston-research-society-symposium.html
 
Description Bristol Grammar School 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Matthew Avison gave a talk entitled 'Superbugs: Is Resistance Futile?' to Bristol Grammar Senior School pupils. Pupils gave feedback such as "I used to think antibiotics were normal when you have a bad cold but I now know it's more likely to be a virus so will only use them if I have to."
Year(s) Of Engagement Activity 2017
 
Description Bristol Health Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Matthew gave a talk to over 100 members of the general public during a session called Bristol Love Bugs. His talk was about the Impact of Antibiotic Use on the Microbiome.
Year(s) Of Engagement Activity 2016
URL http://www.bristolhealthpartners.org.uk/events/view/2016/10/22/bristol-loves-bugs-the-human-microbio...
 
Description Bristol Tackles Global Challenges World Café 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Matthew Avison and Kristen Reyher gave presentations on their work and discussed potential areas of collaboration in the future with researchers from the UK as well as abroad, including many delegates from Thailand. Many interesting ideas came from this week of talks and workshops.
Year(s) Of Engagement Activity 2017
URL http://www.bristol.ac.uk/bristolbridge/events/2017/bristol-tackles-global-challenges.html
 
Description Bristol, North Somerset, South Gloucestershire CCG, One Health AMR meeting (Reyher) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Meeting of the Bristol, North Somerset, South Gloucestershire Clincial Commissioning Group One Health AMR meeting at Bristol Royal Infirmary
Year(s) Of Engagement Activity 2019
 
Description CHAWG AMU Steering group (Reyher) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cattle Health and Welfare Group, Antimicrobial Use Group steering group committee meeting in London
Year(s) Of Engagement Activity 2019
 
Description Capacity Building Workshop for FARMS-SAFE research group 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact The Capacity Building Workshop was held at the Faculty of Veterinary Medicine of University of La Plata from 3rd to 7th February 2020. The workshop was facilitated by the UK & Argentine PIs and CoIs to learn more about farm systems and the data that exists in Argentina, especially in La Plata and Cordoba.
By adopting a participatory approach SOPs were designed for data and sample collection for: i) drafting a national survey & tools for WS1 and WS2, ii) AMU and AMR for WS3, iv) AMR and AM/chemical contamination for WS4 and v) developing a risk-based approach to targeting AMR for WS5. National Autorities from SENASA, academics and postgraduate students from UNLP and Rio Cuarto as well as the team from UoB participated in the meeting.
During the workshop farm visits were organised for both the UK and Argentine colleagues to interview and participatorily observe and analyse the different farming practices among dairy and pig farms around La Plata.
Year(s) Of Engagement Activity 2020
 
Description Cattle Health and Welfare AMU Steering Group (Reyher) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact committee meeting of the steering group on Cattle Health and Welfare at Stoneleigh
Year(s) Of Engagement Activity 2019
 
Description Cheltenham Ladies' College - talk on AMR 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Matthew Avison gave a talk called "Superbugs: Is Resistance Futile?" to 90 students at Cheltenham Ladies College. This talk provoked questions and debate about AMR and Matthew was also approached by students afterwards with further queries.
Year(s) Of Engagement Activity 2017
 
Description Chulabhorn Royal Academy (CRA) Visit 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Worked with Bristol Veterinary School to welcome and discuss opportunities for training and research alongside the Chulabhorn Royal Academy in Thailand
Year(s) Of Engagement Activity 2019
 
Description Clare Phythian (Reyher) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Collaboration with Clare Phythian, visiting researcher from Norwegian University of Life Sciences
Year(s) Of Engagement Activity 2019
URL https://www.nmbu.no/emp/clare.phythian
 
Description Collaborative meeting with Rothamsted Research 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact North Wyke Farm Platform researchers visiting Langford as a collaborative meeting with Rothamsted Research; talked about potential collaborations and updated on work
Year(s) Of Engagement Activity 2019
 
Description Dairy Health Management Continuing Education Programme 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact invited headline presenter as an expert on AMR at Canada's premier training programme for diary veterinarians
Year(s) Of Engagement Activity 2019
URL https://guelphdhmcp.ca/
 
Description Elizabeth Blackwell Institute Research Without Borders Event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Matthew Avison organised and chaired an evening discussion session about AMR from a wide range of perspectives which was conducted as part of a week of events to highlight postgraduate research at the university. The discussion was wide ranging, and members of the public who attended were left clear about the quality of research being conducted, and the complexity of AMR as a problem.
Year(s) Of Engagement Activity 2017
URL http://www.bristol.ac.uk/media-library/sites/doctoral-college/documents/4931_UoB_RwB_A5_Conference_B...
 
Description Filton College 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Matthew gave a talk entitled 'Superbugs: Is Resistance Futile?'. Response was good and some students asked about careers in microbiology.
Year(s) Of Engagement Activity 2016
 
Description Food Industry Initiative on Antimicrobials Research & Development Committee + Data Committee - Quarterly Meeting (Reyher) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Quarterly committee meeting of the Food Industry Initiative on Antimicrobials Research & Development Committee + Data Committee
Year(s) Of Engagement Activity 2019
 
Description GW4 AMR Crucible Talk 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Avison gave a presentation and answered questions about interdisciplinary AMR research to a group of early career researchers from across the GW4 group of universities. The attendees engaged with this online event, and reported being inspired to engage in interdisciplinary research, which was the focus of the event
Year(s) Of Engagement Activity 2020
 
Description Gave talk at Sidmouth Science Festival 2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact About 100 members of the general public attended my talk, "Superbugs: Is Resistance Futile?". Feedback included surprise at "cross resistance caused by biocides," that "antibiotics occur in soils" and "how long E.coli can live in the body". The audience reported changed views such as "I used to think basically that the more antibiotics you used, the healthier and better prepared you were. Now I'll be more cautious."
Year(s) Of Engagement Activity 2016
 
Description Gloucestershire One Health AMR group (Reyher) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Prepared communication plan for Gloucestershire on One Health AMR
Year(s) Of Engagement Activity 2019
 
Description Grant Launch Workshop - UK & Argentina AMR in the environment 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Study participants or study members
Results and Impact The Grant Launch Workshop was organised by BBSRC & CONICET. Five projects funded through DoHSC/UKAid (along with BBSRC & NERC) in the UK and CONICET in Argentina presented their workpackages in order to create a collective proposal to develop a Pan-Program Intregration Project (PPIP) and policy translation activities within the Argentine context. A draft PPIP document was gathered from the workshop aiming to:

- Aim 1 Combine expertise and data from all five project teams to provide consistency to (i) the co-design of policy with agricultural livestock sectors (ii) the measurement of antimicriobial use (AMU) and resistance (AMR), and (iii) knowledge exchange messages across all the livestock species and production systems encompassed by the program.
- Aim 2 "A whole that is greater than the sum of its parts" - to generate research outcomes at the level of the program that would not be possible for any one project alone through combining effort and new work in specifically defined areas.

The aims will be addressed through four work packages. UoB through the FARMS-SAFE project leads Work Package 1 (WP1) - Harmonising antimicrobial use and data collection.
Year(s) Of Engagement Activity 2019
URL https://bbsrc.ukri.org/news/events/2018/1806-argentina-antimicrobial-resistance/
 
Description Host Head of Population Health and Head of Research, Ontario Veterinary College, Guelph University, Ontario, Canada 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Discuss AMR research and possible overlaps in collaborations
Year(s) Of Engagement Activity 2019
 
Description IDF Conference Keynote Speech (Reyher) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Keynote speech by Kristen Reyher on AMR to the International Diary Federation Mastitis Conference 2019 - Social sciences and antimicrobial usage session, title "Antibiotic Anonymous - Playing Our Part in Reducing Antibiotic Usage"
Year(s) Of Engagement Activity 2019
URL https://www.idfmastitis2019.com/keynote-speakers.html
 
Description Inaugural Lecture (Avison) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Avison gave an overview of AMR and focussed on several UKRI funded research projects. The audience asked many questions and there was a vibrant discussion at the reception held afterwards.
Year(s) Of Engagement Activity 2018
 
Description Initial engagement w/ Pan-American Center for Foot and Mouth Disease and Veterinary Public Health, PANAFTOSA-PAHO/WHO 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact The project had an initial engagement with the Food Safety Specialist of the Pan-American Center for Foot and Mouth Disease and Veterinary Public Health at PAHO. It is intended to work closely to boost the AMR information in Argentina jointly with SENASA across the Americas.
Year(s) Of Engagement Activity 2020
 
Description International Antibiotic Usage Forum (Reyher) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Collaborative catch-up with AMR groups around the world - collaborations and contributions to practice
Year(s) Of Engagement Activity 2019
 
Description Interview for BBC Points West 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Discussed AMR research at the Bristol Veterinary School on 14th November 2019.
Year(s) Of Engagement Activity 2019
 
Description Interview with FAIRR re: AMR in livestock 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Interview on 25/09/20 - informed evidence gathering for use in advising a global network of investors - fed into international webinar regarding antimicrobial stewardship by companies
Year(s) Of Engagement Activity 2020
 
Description Involvement in AMR in a Global Context Meeting, Bangkok. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Avison chaired and spoke at a two-day workshop about AMR in Thailand, involving representatives from academia, medicine, agriculture and government ministries. This led to the establishment of a research collaboration and successful GCRF project grant
Year(s) Of Engagement Activity 2017
 
Description Involvement in TV Documentary - Hidden Killers of the Post-War Home 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Matthew Avison participated in a BBC4 documentary produced by Modern Television in a segment about zoonotic pathogens in food and the importance of hand hygine. Significant response on social media and via BBC online fora.
Year(s) Of Engagement Activity 2016
URL http://www.bbc.co.uk/programmes/b07chyly
 
Description Langford Vets Antibiotic Awareness Evening 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact CPD evening for vets, although was also attended by a medical microbiologist and a medical pharmacist. There was much discussion between the speakers and audience, and feedback included: "As a medical microbiologist working in human health in a local hospital, I found it refreshing and very interesting to see the extent, commitment and drive to work to combat antimicrobial resistance in the animal sector - really for the greater good of population health." One vet enquired about consultancy for their practice.
Year(s) Of Engagement Activity 2016
 
Description Lecture to vet students - Bristol University 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Training of practitioners and professionals: Lecture on "Big ideas in veterinary medicine: AMR" to veterinary students
Year(s) Of Engagement Activity 2019
 
Description MOOC, Creating course on antimicrobial stewardship for vets (Reyher) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Discussion about AMR Massive Open Online Course phone meeting re training of practitioners and professionals
Year(s) Of Engagement Activity 2019
 
Description Media Release about Recruitment for Puppy AMR study 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact University of Bristol press release about the initiation of our recruitment drive for Puppies in order to investigate drivers of AMR in these puppies. Picked up by local paper (Bristol Post) and several trade papers (e.g. Dogs Monthly, MRCVS online). Resulted in recruitment of over 250 puppies for the project.
Year(s) Of Engagement Activity 2017
URL https://www.bristol.ac.uk/news/2017/november/puppypoo.html
 
Description Medical Research Foundation AMR PhD student cohort meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Gave a talk at the training day for PhD students - discussed my background and journey in research and AMR research at Bristol - 15th November 2020.
Year(s) Of Engagement Activity 2019
 
Description Meeting with National Milk Labs (Reyher) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Collaboration with FarmAssist, thinking about AMU metrics. Meeting in Langford
Year(s) Of Engagement Activity 2019
 
Description Meeting with representatives of the Welsh Government 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Phone meeting with Welsh Government to discuss about AMR
Year(s) Of Engagement Activity 2019
 
Description NAMRIP/FSA joint workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Kristen Reyher gave a presentation entitled "Auditing for Responsible Antibiotic Use" at a at a Food Standards Agency/University of Southampton workshop tackling AMR and the retail supply chain.
Year(s) Of Engagement Activity 2016
URL http://www.southampton.ac.uk/namrip/news/2016/12/joint-fsa-workshop.page
 
Description NFU Dairy Board Meeting, Bristol Vet School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Matthew Avison, Kristen Reyher and David Barrett spoke to members of the National Farmers Union Dairy board about antimicrobial usage and resistance on Dairy Farms, and other drivers uncovered by this project. Participants expressed satisfaction at the low levels of antimicrobial resistance on farm, and were particularly interested in the non-medicines usage drivers of AMR, particularly the importance of biosecurity.
Year(s) Of Engagement Activity 2017
 
Description NFU Dairy Science Forum Visit 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Visit from NFU expert group on Dairy farming. Presentations to the group about AMR in farming and the OH-STAR project in particular. Stimulated plenty of discussion.
Year(s) Of Engagement Activity 2018
 
Description News Announcement in "Farming UK" 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Write-up about study aims and award details in farming press. Stimulated requests for involvement in the project from farmers and retailers/milk buyers.
Year(s) Of Engagement Activity 2016
URL https://www.farminguk.com/News/-1-5m-research-grant-allows-scientists-to-test-antibiotic-resistance-...
 
Description OH-STAR Farmer Meetings 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Study participants or study members
Results and Impact 71 farmers and 7 vets attended our farmer meetings, where we reminded our farm participants what the project was for, what we were doing, what we were finding so far on their farms. Many farmers said they were surprised that the average level of AMR was so low on farms, and that they were surprised at how little evidence policy has been based on in the dairy industry. One farmer said his trust in scientists was improved.
Year(s) Of Engagement Activity 2017
 
Description OH-STAR Farmers Meetings 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact 80 farmers and 12 vets attended our farmer meetings, where we reminded our farm participants what the project was for, what we were doing, what we were finding so far on their farms. We provided farm level metrics for antimicrobial usage and AMR on the farms at the start of the study and explained how the work would move forward. Many farmers were surprised that their levels of resistance did not seem to associate with their levels of medicines usage, and a significant discussion about other drivers of AMR opened up in which transmission of resistance was highlighted. The likely effect of waste milk feeding was also discussed and there is a changing view on its appropriateness.
Year(s) Of Engagement Activity 2018
 
Description OH-STAR Vet Feedback Meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact We met with veterinary surgeons who had provided data for the OH-STAR Dairy AMR project and fed back key findings of the project. There was much discussion and lots of interest from the practitioners involved. Most agreed to consider their practice in the light of our observations.
Year(s) Of Engagement Activity 2019
 
Description PHE Taunton Workshop - AMR: Working Together to Stem the Tide 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact At this event, which was organised by Public Health England, David Barrett gave a presentation on our AMR work and presented a poster on OH STAR. Feedback, both formal and informal, from the day was very positive. For example, 84% of delegates agreed or strongly agreed that national and local learning had been shared to aid the development of local AMR plans, whilst 92% of delegates felt that they developed an increased understanding of the shared national priorities for AMR.
Year(s) Of Engagement Activity 2016
URL https://www.phe-events.org.uk/HPA/media/uploaded/EVHPA/event_622/AMR_Final_Slides.pdf
 
Description Podcast 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Podcast with Royal College of Veterinary Surgeons Trust on AMR with the UK's Chief Veterinary Officer
Year(s) Of Engagement Activity 2019
 
Description Presentation to Chief Scientific Advisor Chris Whitty 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Professor Chris Whitty, Chief Scientific Advisor for the Department of Health visited University of Bristol to hear of our work and latest findings. Matthew Avison and Ashley Bryce gave presentations, and Professor Whitty sent feedback later in the week saying he'd taken our findings on board and had found the visit useful.
Year(s) Of Engagement Activity 2017
 
Description Project presentation to the research community at University of La Plata 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Organised by the Faculty of Veterinary Medicine of the University of La Plata, up to 60 Postgraduate students and Senior Researchers attended this talk on:

1.Selection and transmission of AMR in a One Health context, Matthew Avison.
2.Investigating prescription, usage and control of veterinary medicines: methods and insights from a social science approach, Maria Paula Escobar.
3.Strategies to optimize antimicrobial efficacy in veterinary medicine in the context of One Health, Nora Mestorino
4.FARMS-SAFE, an overview of the project, Kristen Reyher
Year(s) Of Engagement Activity 2019
 
Description Public Health England/BSAC webinar series on antibiotic prescribing for children - Alastair Hay 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Major contribution to the creation of the TARGET Antibiotic Training Modules, along with Public Health England and BSAC. These are free open access modules to help practitioners improve antibiotic prescribing and the patient experience. These are now accredited for CPD by the Royal College of GPs.
Year(s) Of Engagement Activity 2016
URL http://target-webinars.com/
 
Description RCVS Veterinary Antibiotic Champions initiative 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Engaging with industry and charity stakeholders to offer antimicrobial stewardship to veterinary surgeons across the UK. Stakeholder meeting 26/2/21.
Year(s) Of Engagement Activity 2021
 
Description RUMA Independent Scientific Group committee meeting (Reyher) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Responsible Use of medicines in Agriculture Alliance (RUMA) scientific group meeting in London
Year(s) Of Engagement Activity 2019
 
Description Radio 4 Farming Today - David Barrett Jan 2017 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact David Barrett talked to Farming Today about reducing antibiotics in farming.
Year(s) Of Engagement Activity 2017
URL http://www.bbc.co.uk/programmes/b088b84z
 
Description Research meeting with representative from Boehringer Ingelheim 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Research meeting with representative from Boehringer Ingelheim to discuss AMR topics
Year(s) Of Engagement Activity 2019
 
Description Responsible Use of Medicines in Agriculture Alliance (RUMA) meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact RUMA Cattle Antibiotic Use Targets meeting on 01/09/20 - engaged with industry to encourage reduction of antimicrobials in the cattle sectors
Year(s) Of Engagement Activity 2020
 
Description Responsible use of medicines in Agriculture Alliance (RUMA) Targets Task Force 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Gave an invited talk to challenge livestock industries in AM stewardship targets in Stoneleigh on 10th September 2019
Year(s) Of Engagement Activity 2019
 
Description Royal Society of Biology meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited by the Royal Society of Biology to talk about AMR research, specifically transmission of AMR - overview of talk will be loaded on their blog
Year(s) Of Engagement Activity 2019
 
Description SENASA / ANLIS - Seminar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The seminar "Antimicrobials, One Animal Health and Production" was held at the Laboratory of the National Service of Agrifood Health and Quality (Senasa) in Buenos Aires. Presentations were oriented to the impact of AMR on the environment, animal production, public health and regional economies seeking to highlight the importance of AMR surveillance programs and the way AMR affects national production.

At the end of the event, a discussion table was set up to analyse the perspectives of the different actors working on reducing the impact of AMR and to assess the possible options for a better and coordinated efforts. FARMS-SAFE PI and CoIs attended and contributed to discussions and networking.
Year(s) Of Engagement Activity 2019
 
Description Science Talk on AMR At Beechen Cliffe School, Bath 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Plenty of questions from the audience and general interest by teachers in use of slides in teaching materials.
Year(s) Of Engagement Activity 2018
 
Description Science Talk on AMR At New College Swindon 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Plenty of questions from the audience and general interest by teachers in use of slides in teaching materials.
Year(s) Of Engagement Activity 2018
 
Description Science Talk on AMR at Abbywood School 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Plenty of questions from the audience and general interest by teachers in use of slides in teaching materials.
Year(s) Of Engagement Activity 2018
 
Description Semex International Dairy Conference Glasgow 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact David Barrett gave a talk at the Semex Conference, whose delegation is mainly farmers and associated professionals. Questions and tweets ensued, so an audience was reached far outside those hundreds present.
Year(s) Of Engagement Activity 2017
 
Description Sheldon School - AMR talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Matthew Avison gave a talk entitled 'Superbugs: Is Resistance Futile?' to 80 secondary school pupils. Students asked questions about antibiotics and resistant bacteria and the school sent good feedback about the talk.
Year(s) Of Engagement Activity 2017
 
Description South West Zoonoses Liason Group meeting - Nov 2016 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact David Barrett was invited to talk to the South West Zoonoses Group about our AMR work at University of Bristol. This group is made up of medical practitioners and members of Public Health England. Some misconceptions of the group's medical delegates were discussed and reinformed.
Year(s) Of Engagement Activity 2016
 
Description Speak with BBC Radio4 Costing the Earth 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Phone interview with the BBC Radio4 to discuss AMR research - background information to be used in radio presentation
Year(s) Of Engagement Activity 2020
 
Description Speak with Channel 4 Dispatches 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Phone interview with Channel 4 Dispatches to inform a documentary about food safety
Year(s) Of Engagement Activity 2020
 
Description St Lawrence School talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Matthew gave a talk entitled 'Superbugs: Is Resistance Futile?' There were many interesting questions from pupils and teachers reported the kids felt they had learnt a lot.
Year(s) Of Engagement Activity 2016
 
Description Surgeon X Comic 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Matthew Avison was asked to advise and contribute to the Surgeon X comic (Wellcome Trust Funded), which imagines a world beyond the antibiotic age, which was published via Wowbagger Productions. The comic is sold in print form and via an app. There has been significant international impact.
Year(s) Of Engagement Activity 2016
URL http://surgeonx.co.uk/our-team/
 
Description Swindon College AMR talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Matthew Avison gave a talk entitled 'Superbugs: Is Resistance Futile?' This was to inspire a new generation of microbiologists and raise awareness of AMR. Students fed back change in perceptions and increased interest in microbiology.
Year(s) Of Engagement Activity 2017
 
Description Talk At OH-DART Launch Bangkok 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Avison gave a talk at the launch of the OH-DART AMR project, attended by Thai government ministers and other key stakeholders. The aim was to discuss the aims of the project and to obtain feedback about deliverables and stakeholder engagement.
Year(s) Of Engagement Activity 2019
 
Description Talk at "AMR in the Real World" Meeting Bristol 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Avison organised, chaired and spoke at a one day symposium at the university of Bristol bringing together the 13 consortia funded under the NERC AMR Theme 3 call, alongside stakeholders, funders and other relevant parties. There was much important discussion about the findings of the project and future potential collaborations. One attendee, from the U3A - a key stakeholder group - wrote a report about the event published in the U3A national magazine (125,000 circulation) entitled "No pooh-poohing research".
Year(s) Of Engagement Activity 2017
 
Description Talk at BSAC Antimicrobial Resistance Mechanisms Meeting, Birmingham 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Matthew Avison was invited to speak about the links between antibiotic resistance in animals and antibiotic resistant infections at the annual British Society for Antimicrobial Chemotherapy meeting in Birmingham. Attendees were primarily postgraduate students, who used this session as a primer for their understanding of the complexities of this problem. There was significant discussion afterwards.
Year(s) Of Engagement Activity 2017
 
Description Talk at Chulabhorn Research Institute, Bangkok (Avison) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Avison delivered a talk at Chulabhorn research institute about his AMR research portfolio, which led to discussions about collaboration, and ultimately, a GCRF funded collaborative project
Year(s) Of Engagement Activity 2017
 
Description Talk at One Health Eden Antimicrobial Resistance Conference, Cornwall 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Avison spoke on the links between antimicrobial usage in farming and AMR in humans for an NHS organised One-Health research day covering AMR from a number of angles. There was a wide range of questions and discussion. The talk was filmed and is available on You-Tube.
Year(s) Of Engagement Activity 2017
URL https://www.youtube.com/watch?v=ewW7gDGYVxM
 
Description Talk at University of La Plata Argentina 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Avison gave a talk about the findings of the OH-STAR Dairy farm AMR project to an expert audience in the Faculty of Veterinary Sciences. This was the start of a wider collaboration with partners in Argentina.
Year(s) Of Engagement Activity 2019
 
Description Talk at Warwick SWON Alliance Industry day. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Talk at the SWAN industry day to industry and academic representatives. Significant interest generated in methods for determining antibiotic action via proteomics
Year(s) Of Engagement Activity 2016
URL https://www2.warwick.ac.uk/fac/cross_fac/wamic/swon/industry/
 
Description Veterinary Record News Article 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Announced the award and the aims of the project to veterinary professionals and stakeholders; a number of enquiries about involvement in the project were received.
Year(s) Of Engagement Activity 2016
URL http://veterinaryrecord.bmj.com/content/178/25/622
 
Description Veterinary Schools Council AMR (Reyher) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact phone meeting
Year(s) Of Engagement Activity 2019
 
Description Veterinary Schools Council, AMR (Reyher) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Phone meeting with committee
Year(s) Of Engagement Activity 2019
 
Description Webinar training Welsh farm vets on antimicrobial stewardship, UK 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Arwain Vet Cymru Webinar for veterinary practitioners on 14/10/20 - inspired veterinarians to design antimicrobial stewardship interventions in their veterinary practices
Year(s) Of Engagement Activity 2020
 
Description Winterbourne International Academy - school talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact Parents and pupils of Winterbourne Academy attended their Festival of Science lectures, one of which was a talk by Matthew entitled "No more drugs for superbugs"
Year(s) Of Engagement Activity 2016
URL http://www.myyate.co.uk/yate/e/18972/festival-of-science-lectures
 
Description World Antibiotic Awareness Week - with Public Health England at WeTheCurious, Bristol 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact We talked to members of the public and children about our research, explaining how it impacts them.
Year(s) Of Engagement Activity 2017