Genomic analysis of neurodegenerative disease

Lead Research Organisation: University College London

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The UK Dementia Research Institute (UK DRI) is an initiative funded by the Medical Research Council, Alzheimer's Society and Alzheimer's Research UK. Funding details for UK DRI programmes will be added in 2019.

My interest is in the genetic basis of neurodegenerative diseases: we are interested in finding the genetic causes of all mendelian neurodegenerative disease and in finding risk genes though genome sequencing and genome wide association studies. Additionally, we are interested in the genetic underpinnings of phenotypic differences between individuals with the same diagnoses: what influences the rate of progression of disease: what influences the precise clinical features etc.? Our aim is to integrate the genetic findings we and others make with gene expression changes in the human and mouse model brain and in other relevant tissues and to use statistical and bioinformatic analyses to understand more completely the pathogeneses of these diseases. Since we believe that for mechanistic treatments to be effective in disease we need to initiate them before the disease is clinically apparent, we also want to help to develop algorithms using either genetic data alone, or genetic and phenotypic data, to make risk prediction effective enough to have clinical utility in designing mechanistic trials.

Publications

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Bandres-Ciga S (2019) The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease. in Movement disorders : official journal of the Movement Disorder Society

 
Description "Genomics in Neurodegenerative disease -- what are we up to" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited Lecture as HKUST IAS fellow, Hong Kong
Year(s) Of Engagement Activity 2019
 
Description "Neurogenetic Foundations of Movement Disorders - The Key to Cure?" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited Keynote Lecture
Year(s) Of Engagement Activity 2019
 
Description "The Genetics of the Dementias" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Invited teaching lecture at Queen Square on MSc Human Genetics course 2018-19
Year(s) Of Engagement Activity 2019
 
Description Advances in Alzheimer's Disease 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited speaker - The 10th Xiangya International Symposium of the Clinical and Basic Research on Neurodegenerative Disorders, China
Year(s) Of Engagement Activity 2019
 
Description Alzheimer's disease pathogenesis: what do we know and why have clinical trials failed 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Patients, carers and/or patient groups
Results and Impact Invited public lecture
Year(s) Of Engagement Activity 2019
 
Description Aß hypothesis, AD genetics" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited lecture - Wenner-Gren Center (Sveavägen 166), Stockholm, Sweden
symposium : "Amyloid diseases: from biochemistry to clinical applications"
Year(s) Of Engagement Activity 2019
 
Description Crispr Talk - John and Selina 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Invited Lecture Royal London Hospital
Year(s) Of Engagement Activity 2019
 
Description Epidemiology of Alzheimer's Disease and Related Disorders 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited Keynote speaker on teaching course at Bordeaux School of Neuroscience
Year(s) Of Engagement Activity 2019
 
Description Genetic analysis of late onset degenerative diseases implicates failures of damage response 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Speaker invitation and Announcement of The Brain Prize Awardee 2019 Copenhagen, Denmark
Year(s) Of Engagement Activity 2019
 
Description Genetics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited Lecture - Wolfson Institute for Biomedical Research (WIBR) mini-symposium - Sainsbury Wellcome Centre London
Year(s) Of Engagement Activity 2019
 
Description Genetics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Supporters
Results and Impact Wolfson final symposium - Institute of Child Health London
Year(s) Of Engagement Activity 2019
 
Description Genetics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Supporters
Results and Impact Invited Lecture Weston's meeting - 50th Year Anniversary Symposium, 33 Queen Square
Year(s) Of Engagement Activity 2019
 
Description Genetics in neurodegenerative disease 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited lecture at 2019 International Conference of Korean Dementia Association, (IC-KDA 2019) Seoul
Year(s) Of Engagement Activity 2019
 
Description Genetics in neurodegenerative diseases 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Invited teaching to PhD students on Biomarkers for neurodegenerative diseases PhD course
Year(s) Of Engagement Activity 2019
 
Description Genetics of Alzheimer's 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited lecture at Hong Kong University of Science and Technology ShenZhen branch
Year(s) Of Engagement Activity 2019
 
Description Genetics of Alzheimer's and other neuro-degenerative disease 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited Lecture - China National Genebank - Jinsha Road, Dapeng New District, Shenzhen
Year(s) Of Engagement Activity 2019
 
Description Genetics of Dementias 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited Lecture XXIV World Congress of Neurology, Dubai - AE
Year(s) Of Engagement Activity 2019
 
Description Genetics of Neurodegeneration 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited Lecture at Lisbon AD/PD meeting
Year(s) Of Engagement Activity 2019
 
Description Genomic analysis of neurodegenerative diseases 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited lecture Scientific Talk (to senior scientists) Odense University Hospital, Denmark
Year(s) Of Engagement Activity 2019
 
Description Genomic analysis of the mechanisms of neurodegenerative disease in Denmark to PhD students 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Teaching Lecture to PhD students in neuroscience at the NeuroGrad Winter School, Copenhagen
Year(s) Of Engagement Activity 2019
URL https://neurograd.ku.dk/neurograd-winter-school/
 
Description Genomic clues to neurodegenerative disease mechanisms 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Brain Prize Special Lecture/ keynote lecture at ECNP Congress in Copenhagen
Year(s) Of Engagement Activity 2019
 
Description Genomics of Neurodegeneration 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited lecture - 3rd Rijeka Forum on Neurodegenerative diseases, Croatia Rijeka
Year(s) Of Engagement Activity 2019
 
Description Genomics of neurodegenerative disease 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Keynote speaker FENS The Serbian Neuroscience Society. with the Neuroscience societies of Romania and Turkey.
Belgrade Serbia.
Year(s) Of Engagement Activity 2019
 
Description Inaugural Baillieu Myer Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Inaugural Baillieu Myer Lecture, in honour of contribution to medical research, in particular dementia research
Year(s) Of Engagement Activity 2019
 
Description Invited Round table public talk 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited public round table - Brain Prize Evening - Lundbeck - BNA Festival, The Convention Centre Dublin
Year(s) Of Engagement Activity 2019
 
Description Invited talk to the Elderly 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Patients, carers and/or patient groups
Results and Impact Invited speaker at Chinese Dementia Meeting at Community Elder Center at Hebei, China
Year(s) Of Engagement Activity 2019
 
Description Meet the Professors 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited Round table public talk
Year(s) Of Engagement Activity 2019
 
Description Neanderthals - talk for The National Trust 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Lecture in response to a request to talk to a regional National Trust membership
Year(s) Of Engagement Activity 2019
 
Description Opening lecture: Alzheimer's disease: a personal view on early diagnosis and treatment 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited Lecture - XVIII Teófilo Hernando's International Summer School of Pharmacology
Frontier Biomarkers and Drug Discovery for the Early Diagnosis and Treatment of Alzheimer's Disease
Year(s) Of Engagement Activity 2019
 
Description Progress in the genomic analysis of neurodegeneration 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Lecture to the department of Neurodegenerative Disease as an update on work in progress
Year(s) Of Engagement Activity 2019
 
Description Rethinking PD: From a Single Disease to Multiple Diseases:: Genetics, Epigenetics and Environmental Factors 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited Lecture by The Preuss Foundation Seminar on State of the Art Parkinson's Disease Research ~ La Jolla, California
Year(s) Of Engagement Activity 2019
 
Description Session 4 - Panel discussion: 'The Future of Neuroscience' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Invited Lecture - UCL Neuroscience Symposium 10th Anniversary, UCL Institute of Education
Year(s) Of Engagement Activity 2019
 
Description Skype 2 hour lecture to students 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited Teaching Lecture to Masters Students
"Athens International Master's Programme in Neurosciences"
University of Athens
Department of Biology
Year(s) Of Engagement Activity 2019
 
Description The importance of genetics and molecular biology in neurodegenerative diseases 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Invitation to Lecture on MRes Translational Neuroscience programme - 7 Queen Square
Year(s) Of Engagement Activity 2019
 
Description The importance of genetics and molecular biology in neurodegenerative diseases 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Invited teaching UCL - Basic neuroscience and investigation of Nervous system - CLNE0009 Queen Square
Year(s) Of Engagement Activity 2019
 
Description The role of genetics and genetic testing in PD 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited Lecture at World Parkinson Coalition 2019 Kyoto, Japan
Year(s) Of Engagement Activity 2019
 
Description talk on Genetics at McGill University in Canada 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited Lecture
Year(s) Of Engagement Activity 2019