Driving synaptic repair in early neurodegeneration

Lead Research Organisation: University of Cambridge

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The UK Dementia Research Institute (UK DRI) is an initiative funded by the Medical Research Council, Alzheimer's Society and Alzheimer's Research UK. Funding details for UK DRI programmes will be added in 2019.

Synapse loss underlies the earliest symptoms in several neurodegenerative diseases; its progression eventually leads to neuronal loss. Critically, it is an early stage in pathogenesis that can be rescued (Science 2003; 302, 871-4; Neuron 2007; 53, 325-35) and is therefore a key therapeutic target for intervention. In the healthy adult brain synapses are continually lost and replaced, through structural plasticity, a process critical for repair that also underlies learning and memory. We have shown that neurodegeneration results, at least in part, from a failure of structural synaptic plasticity early in the disease process (Nature 2015; 518, 236-9). Using the paradigm of cooling-induced structural plasticity that occurs in hibernation in prion-diseased and AD mouse models (5xFAD mice and tauopathy frontotemporal dementia (FTD) mice), we: 1) showed that the capacity for synaptic repair and reassembly is impaired in several mouse models of neurodegenerative disease; 2) found that this results from failure to induce the cold shock
protein, the RNA chaperone: RNA binding motif 3 (RBM3); and 3) defined the major role of RBM3 in maintaining structural plasticity and driving synaptic repair. Critically, we have shown the therapeutic potential of manipulation of RBM3 levels for neuroprotection

Publications

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Gonzalez-Teuber V (2019) Small Molecules to Improve ER Proteostasis in Disease. in Trends in pharmacological sciences

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Halliday M (2017) Reply: Trazodone to change the risk of neurodegeneration: bedside to bench. in Brain : a journal of neurology

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Halliday M (2017) Fine-tuning PERK signaling for neuroprotection. in Journal of neurochemistry

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Halliday M (2019) Translating translation in Down syndrome. in Science (New York, N.Y.)

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Knight JRP (2020) Control of translation elongation in health and disease. in Disease models & mechanisms

 
Description Chan Zuckerberg initiative Neuro Collaborative Pairs RFA Panel member
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description International Scientific Advisory Board, Wallenberg Center for Molecular Medicine, Linkoping, Sweden
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
 
Description MRC Unit and Centre Portfolio Review's Molecular and Cell Domain Panel
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Scientific Advisory Board Astex Pharmaceuticals
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Scientific review panel: Scientific Foundation of Ireland
Geographic Reach Europe 
Policy Influence Type Membership of a guideline committee
 
Description Wellcome Trust Cell and Molecular Neuroscience Panel
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description CoEN
Amount £196,033 (GBP)
Funding ID MR/S00503X/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 05/2018 
End 04/2020
 
Description Developing a cell-based, high-throughput assay to repurpose drugs for the treatment of neurodegeneration
Amount £28,000 (GBP)
Funding ID RG93172/MALLUCCI/31840 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 12/2018 
End 05/2019
 
Description Developing the repurposed neuroprotective drug trazodone for clinical trials
Amount £55,000 (GBP)
Organisation Medical Research Council (MRC) 
Department MRC Confidence in Concept Scheme
Sector Charity/Non Profit
Country United Kingdom
Start 01/2019 
End 09/2019
 
Description Frances and Augustus Newman Foundation postgraduate scholarship between the UK DRI and Dept. Chemistry at the University of Cambridge. £264K. Co-PI
Amount £264,000 (GBP)
Organisation The Frances and Augustus Newman Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Gnodde Goldman Sachs Translational Neuroscience Group
Amount £1,124,054 (GBP)
Organisation Goldman Sachs 
Department Goldman Sachs Gives UK
Sector Charity/Non Profit
Country United Kingdom
Start 01/2019 
End 01/2024
 
Description Identification of neurodegenerative stress response modulators in young and aged iNeurons Collaborators
Amount £555,000 (GBP)
Funding ID OTAR2-054 
Organisation The Wellcome Trust Sanger Institute 
Department Open Targets
Sector Academic/University
Country United Kingdom
Start 04/2018 
End 04/2021
 
Description Joint Programming in Neurodegenerative Diseases
Amount £348,913 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 02/2018 
End 01/2021
 
Description Altered mRNA translation as a pathogenic mechanism across ND 
Organisation Max Planck Society
Department Max Planck Institute for Brain Research
Country Germany 
Sector Academic/University 
PI Contribution Expertise in the field of neurodegeneration and the unfolded protein response
Collaborator Contribution Expertise in mRNA translation and neurodegenerative diseases
Impact None so far
Start Year 2018
 
Description Altered mRNA translation as a pathogenic mechanism across ND 
Organisation Max Planck Society
Department Max Planck Institute for Molecular Biomedicine
Country Germany 
Sector Academic/University 
PI Contribution Expertise in the field of neurodegeneration and the unfolded protein response
Collaborator Contribution Expertise in mRNA translation and neurodegenerative diseases
Impact None so far
Start Year 2018
 
Description Altered mRNA translation as a pathogenic mechanism across ND 
Organisation McGill University
Country Canada 
Sector Academic/University 
PI Contribution Expertise in the field of neurodegeneration and the unfolded protein response
Collaborator Contribution Expertise in mRNA translation and neurodegenerative diseases
Impact None so far
Start Year 2018
 
Description Altered mRNA translation as a pathogenic mechanism across ND 
Organisation National Institute of Health and Medical Research (INSERM)
Country France 
Sector Academic/University 
PI Contribution Expertise in the field of neurodegeneration and the unfolded protein response
Collaborator Contribution Expertise in mRNA translation and neurodegenerative diseases
Impact None so far
Start Year 2018
 
Description Collaboration: David Rowitch, Cambridge 
Organisation University of Cambridge
Department Department of Clinical Neurosciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Expertise in neurodegeneration, unfolded protein response, cold shock response and mouse models of ND
Collaborator Contribution Expertise in glial biology
Impact Joint paper Astrocytic UPR causes non-cell autonomous neurotoxicity and represents new therapeutic target for neurodegenerative disease. Smith H, Freeman OJ, Butcher AJ, Holmqvist S, Humoud I, Schätzl T, Hughes DT, Verity NC, Swinden DP, Hayes J, de Weerd L, Rowitch DH, Franklin RJM, Mallucci GR. Neuron. 2020 Jan 2. pii: S0896-6273(19)31056-6. doi: 10.1016/j.neuron.2019.12.014.
Start Year 2017
 
Description Collaboration: David Rubinsztein UKDRI@Cambridge 
Organisation UK Dementia Research Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Expertise in UPR and neurodegeneration
Collaborator Contribution Expertise in autophagy and HD
Impact joint project successful PhD studentship
Start Year 2017
 
Description Collaboration: Edward Avezov UKDRI@Cambridge 
Organisation UK Dementia Research Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Expertise in neurodegeneration, unfolded protein response, cold shock response and mouse models of ND
Collaborator Contribution Expertise in ER structure and regulation
Impact none yet
Start Year 2018
 
Description Collaboration: Henrik Zetterburg UKDRI@Cambridge 
Organisation UK Dementia Research Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Expertise in neurodegeneration, unfolded protein response, cold shock response and mouse models of ND
Collaborator Contribution Expertise in biomarkers for AD and dementia
Impact Joint project
Start Year 2018
 
Description Collaboration: Kobi Rozenblum Haifa 
Organisation University of Haifa
Country Israel 
Sector Academic/University 
PI Contribution Expertise in UPR, Neurodegeration and cold shock response
Collaborator Contribution Expertise in Cellular mechanisms of learning and memory
Impact joint project
Start Year 2017
 
Description Collaboration: Marc -David Ruepp UKDRI@ King's 
Organisation UK Dementia Research Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Expertise in Cold shock response and ND, Experiments in mouse models of ND
Collaborator Contribution Expertise in cell stress
Impact Joint funded project
Start Year 2020
 
Description Collaboration: Marie-Christine Chartier-Harlin, INSERM, 
Organisation National Institute of Health and Medical Research (INSERM)
Country France 
Sector Academic/University 
PI Contribution Expertise and scientific knowledge in UPR, neurodegeneration and the cold shock response
Collaborator Contribution Expertise in molecular mechanisms of AD and PD
Impact none to date
Start Year 2017
 
Description Collaboration: Mark Kotter, BitBio, 
Organisation Bit.Bio
Country United Kingdom 
Sector Private 
PI Contribution Scientific knowledge and expertise in neurodegeneration, UPR regulation and RBM3 induced synaptic plasticity
Collaborator Contribution Scientific knowledge and expertise in stem cell research
Impact none to date
Start Year 2019
 
Description Collaboration: Robin Franklin, Cambridge 
Organisation University of Cambridge
Department Cambridge Stem Cell Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Expertise in neurodegeneration, unfolded protein response, cold shock response and mouse models of ND
Collaborator Contribution Expertise in glial biology
Impact Joint paper: Astrocytic UPR causes non-cell autonomous neurotoxicity and represents new therapeutic target for neurodegenerative disease. Smith H, Freeman OJ, Butcher AJ, Holmqvist S, Humoud I, Schätzl T, Hughes DT, Verity NC, Swinden DP, Hayes J, de Weerd L, Rowitch DH, Franklin RJM, Mallucci GR. Neuron. 2020 Jan 2. pii: S0896-6273(19)31056-6. doi: 10.1016/j.neuron.2019.12.014.
Start Year 2017
 
Description Collaboration: Tuomas Knowles, Uni of Cambridge 
Organisation University of Cambridge
Department Department of Chemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution Expertise in neurodegeneration, unfolded protein response, cold shock repsonse
Collaborator Contribution Expertise in biophysics , chemical kinetics
Impact Donation from the Newman Trust Foundation to part fund two translational PhD studentships shared between UK DRI@Cambridge and Dept. Chemistry, University of Cambridge. Studentships to start in Jan 2021
Start Year 2020
 
Description Collabration; E.Metzakopian (UKDRI), Alex Gutteridge (GSK), Andrew Bassett (Sanger), Sandi Engle (Biogen) 
Organisation Biogen
Country United Kingdom 
Sector Private 
PI Contribution Expertise in neurodegeneration, unfolded protein response, cold shock response and mouse models of ND
Collaborator Contribution Expertise in iPSC cells and CRISPR screens
Impact Joint Open Targets grant
Start Year 2019
 
Description Collabration; E.Metzakopian (UKDRI), Alex Gutteridge (GSK), Andrew Bassett (Sanger), Sandi Engle (Biogen) 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution Expertise in neurodegeneration, unfolded protein response, cold shock response and mouse models of ND
Collaborator Contribution Expertise in iPSC cells and CRISPR screens
Impact Joint Open Targets grant
Start Year 2019
 
Description Collabration; E.Metzakopian (UKDRI), Alex Gutteridge (GSK), Andrew Bassett (Sanger), Sandi Engle (Biogen) 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Expertise in neurodegeneration, unfolded protein response, cold shock response and mouse models of ND
Collaborator Contribution Expertise in iPSC cells and CRISPR screens
Impact Joint Open Targets grant
Start Year 2019
 
Description Collabration; E.Metzakopian (UKDRI), Alex Gutteridge (GSK), Andrew Bassett (Sanger), Sandi Engle (Biogen) 
Organisation UK Dementia Research Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Expertise in neurodegeneration, unfolded protein response, cold shock response and mouse models of ND
Collaborator Contribution Expertise in iPSC cells and CRISPR screens
Impact Joint Open Targets grant
Start Year 2019
 
Description Glial biology and brain stem cells 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Expertise in in ND and matching funds toward equipment
Collaborator Contribution Expertise in Glial biology and funds towards equipment
Impact Publication: Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration. Smith HL, Freeman OJ, Butcher AJ, Holmqvist S, Humoud I, Schätzl T, Hughes DT, Verity NC, Swinden DP, Hayes J, de Weerd L, Rowitch DH, Franklin RJM, Mallucci GR. Neuron. 2020 Mar 4;105(5):855-866.e5. doi: 10.1016/j.neuron.2019.12.014. Epub 2020 Jan 7.
Start Year 2018
 
Description Glial biology and brain stem cells 
Organisation Wellcome Trust
Department Wellcome - MRC Cambridge Stem Cell Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Expertise in in ND and matching funds toward equipment
Collaborator Contribution Expertise in Glial biology and funds towards equipment
Impact Publication: Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration. Smith HL, Freeman OJ, Butcher AJ, Holmqvist S, Humoud I, Schätzl T, Hughes DT, Verity NC, Swinden DP, Hayes J, de Weerd L, Rowitch DH, Franklin RJM, Mallucci GR. Neuron. 2020 Mar 4;105(5):855-866.e5. doi: 10.1016/j.neuron.2019.12.014. Epub 2020 Jan 7.
Start Year 2018
 
Description Identification of compounds targeting RBM3 
Organisation Alzheimer's Research UK
Department Cambridge Drug Discovery Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Scientific knowledge and expertise in synaptic plasticity, RBM3 and neurodegeneration
Collaborator Contribution Scientific knowledge and expertise in drug discovery
Impact none so far
Start Year 2018
 
Description In-vivo PET imagining of Neurodegeneration 
Organisation University of Cambridge
Department Wolfson Brain Imaging Centre
Country United Kingdom 
Sector Academic/University 
PI Contribution mice for the study and biochemical and histological analyses for confirmation of disease progression and efficacy of treatment.
Collaborator Contribution development and preparations of PET radiotracers for imaging research PET data acquisition and analysis
Impact none yet
Start Year 2013
 
Description Investigating chromatin landscapes in ND models 
Organisation German Centre for Neurodegenerative Diseases
Country Germany 
Sector Public 
PI Contribution Expertise in neurodegenerative models
Collaborator Contribution Expertise in chromatin remodelling and analysis
Impact None so far
Start Year 2018
 
Description Investigation RBM3 and RTN3 function, with super-resolution microscopy and biophysical 
Organisation University of Cambridge
Department Department of Chemical Engineering and Biotechnology
Country United Kingdom 
Sector Academic/University 
PI Contribution Scientific knowleldge, expertise and samples relating to RBM3 and neurodegernation
Collaborator Contribution Prof C.Kaminski : Scientific knowledge and expertise in super-resolution microscopy and super-resolution equipment.
Impact None yet
Start Year 2017
 
Description Modulation of local synaptic translation 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Scientific knowledge and expertise in neurodegeneration, UPR regulation and RBM3 induced synaptic plasticity 1 post doc 1 student
Collaborator Contribution Prof. C.Holt: Scientific knowledge and expertise neuronal RNA translation regulation
Impact Article publication: 3. Non-canonical modulation of eIF2 pathway controls increase in local translation during neural wiring. Cagnetta E, Wong HH, Free CK, Mallucci GR, Krijgsveld J, Holt CE. Molecular Cell 2019 l doi.org /10.1016/ j.molcel.2018.11.013
Start Year 2017
 
Description Regulation of protein synthesis by elongation control in health and disease 
Organisation Beatson Institute for Cancer Research
Country United Kingdom 
Sector Academic/University 
PI Contribution Expertise in protein synthesis regulation in neurodegenerative disease
Collaborator Contribution Expertise and resources in RNA biology, systems biology and cancer biology
Impact None so far
Start Year 2016
 
Description Regulation of protein synthesis by elongation control in health and disease 
Organisation Medical Research Council (MRC)
Department MRC Toxicology Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution Expertise in protein synthesis regulation in neurodegenerative disease
Collaborator Contribution Expertise and resources in RNA biology, systems biology and cancer biology
Impact None so far
Start Year 2016
 
Description Regulation of protein synthesis by elongation control in health and disease 
Organisation University of Kent
Country United Kingdom 
Sector Academic/University 
PI Contribution Expertise in protein synthesis regulation in neurodegenerative disease
Collaborator Contribution Expertise and resources in RNA biology, systems biology and cancer biology
Impact None so far
Start Year 2016
 
Title SUPER-D and SUPER-D2 
Description experimental medicines studies; trazodone and cerebral protein synthesis rates 
Type Support Tool - For Fundamental Research
Current Stage Of Development Initial development
Year Development Stage Completed 2018
Development Status Under active development/distribution
Impact None so far 
 
Description 27th Annual Meeting of the Network for European CNS Transplantation & Restoration (NECTAR), Dublin 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Definite increased interest from the students/patients at the conference as the following tweets show:

Tour de force from Giovanna Mallucci from the Dementia Research Institute on pharmacological approaches to prion disease and neurodegeneration. Outstanding data and superb speaker.

Wow! #NECTAR2017 - What an epic rollercoaster ride of a conference! We cannot thank you all enough for making it so great. The science, the emotion, the tears and all of the Tweets.

Sitting in at @NECTAR_EU Conference in Malahide, Dublin for the past few days. I won't lie, this stuff is way over my head but these guys at #NECTAR2017 are rooting for me and everyone with #Parkinsons and I'm eternally grateful

Back in the lab. Those stem cells won't grow themselves! #teamdowd #NECTAR2017 #WomenInSTEM
Year(s) Of Engagement Activity 2017
 
Description 2nd Molecular Biology of Ageing Meeting 2017, The Netherlands 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk on Manipulating the Unfolded Protein Response for treatment of neurodegeneration
Year(s) Of Engagement Activity 2017
 
Description 6th European Synapse Meeting, Milan 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The aim of this meeting is to bring together junior and senior neuroscientists working on synapses and to provide a forum for new directions and ideas in synapse research. This serves to create a European research community with an active role in promoting synaptic research and its funding within the EU. The meeting welcomes participation from all neuroscientists within and outside the EU.
Year(s) Of Engagement Activity 2017
URL https://www.fens.org/News-Activities/Calendar/Meetings/2017/12/6th-EUROPEAN-SYNAPSE-MEETING/
 
Description 7th Optic Nerve Meeting, Obergurgl, Austria 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Intended for basic scientists and clinicians to address important topics in translational research, including scientists in interdisciplinary areas such as neurology, neurodegenerations and autoimmunity
Year(s) Of Engagement Activity 2017
URL http://www.optic-nerve-online.com/images/Agenda/2017OpticNerveMeeting_FinalAgenda.pdf
 
Description Alzheimer's Research UK - Staff Away Day 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Supporters
Results and Impact Talk at the Alzheimer's Research UK annual staff away day. Raising awareness about the activities of the Cambridge DRI.
Year(s) Of Engagement Activity 2019
 
Description Alzheimer's Research UK Conference 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact tba
Year(s) Of Engagement Activity 2017
 
Description Cambridge Festival of Science 2019 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Cambridge Science Festival brings science, technology, engineering, maths and medicine to an audience of all ages through demonstrations, talks, performances and debates. Run by the University of Cambridge, the Festival draws together independent organisations in addition to many University Departments, Centres and Museums. Most events are free.
Year(s) Of Engagement Activity 2019
URL https://www.sciencefestival.cam.ac.uk/news/biomedical-campus-welcomes-back-science-festival
 
Description Cambridge Society of Paris, Annual Dinner 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The Cambridge Society of Paris has been active since 1996 and provides a platform for Cambridge graduates, mostly based in and around Paris, to retain a contact with the University through the activities and events of the Society.
We aim to be a focal point to enable University alumni to enjoy themselves, to meet others to mutual benefit and to use the talents they honed during their time at Cambridge to help others on their way.
Year(s) Of Engagement Activity 2019
URL https://cambridgesocietyofparis.com/event/the-2019-annual-dinner-with-our-guest-speaker-sir-christop...
 
Description Clinician Scientist Symposium on Translational Medicine 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Giovanna Mallucci was invited to present the keynote lecture.
This is a two-day Clinician Scientist Symposium on Translational Medicine is held in Berlin every two years. The Clinician Scientists can invite internationally renowned physicians and researchers to attend the event as speakers and this means the Clinician Scientists can discuss their project in person with leading figures in their own research field. The Clinician Scientists also have the opportunity to present their research during the symposium (in the form of a short talk or poster presentation).

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Year(s) Of Engagement Activity 2018
 
Description Dementias Conference 2019, London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Keynote address on 'The UK Dementia Research Institute', delivered by its Associate Director Professor Giovanna Mallucci. This initiative aims at accelerating the discovery of new treatments and better care for people with dementia by focusing research on how dementias develop and progress.
Year(s) Of Engagement Activity 2019
URL https://www.acnr.co.uk/2019/08/dementias-2019/
 
Description From synapses to memory: RNA based regulatory mechanisms 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The meeting aimed to bring together leading investigators and young scientists from the field. These investigators employ a wide range of techniques such as computational modeling, genome-wide sequencing, genetic manipulation and cellular imaging. They discussed fundamental aspects of RNA based regulation of memory formation and its alterations in neurodevelopmental disorders associated with memory dysfunction. This meeting will be a platform for stimulating informal yet intense discussions and also foster active collaboration that will certainly take this field into a new direction.

Professor Mallucci delivered the Keynote Lecture entitled "Cooling synapses: RNA chaperones and neuroprotection"
Year(s) Of Engagement Activity 2018
 
Description Futures Congress in Santiago de Chile 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Invited by Senator Girardi, President of the Senate's Future Challenges, Science, Technology and Innovation Commission in Chile, to participate as a Guest Speaker in the VIII Futures Congress (Congreso Futuro in Spanish), "a global flagship knowledge engagement event set to take place between the 14th-20th January 2019". Since the establishment of the Futures Congress in 2011, it has become a major forum in Latin America for addressing the many challenges that humanity is faced with and brings together scientists and humanists to discuss how we can achieve a better future.
Congreso Futuro is unique in the region for providing Nobel laureates, scientists, researchers, artists, opinion leaders and citizens alike "the opportunity to experience some of the world's most cutting-edge research, participate in the understanding of emerging trends and actively engage in the innovation of ideas and debates that directly influence the globe."
Approximately 40,000 people directly attended events of last year's Congreso Futuro around the country. The talks are live-streamed and covered on national TV.
Year(s) Of Engagement Activity 2019
 
Description Glioma/Translation/Metabolism Workshop, Glasgow 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Glioma/translation/metabolism grant workshop at Glasgow University
Year(s) Of Engagement Activity 2019
 
Description Isle of Man Dementia Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Supporters
Results and Impact Talk on the potential use of Trazadone in preventing the formation of tau tangles at the Isle of Man Dementia Conference - Alzheimer's Society.
Year(s) Of Engagement Activity 2019
 
Description MRC Protein Phosphorylation Unit, Dundee 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Talk to MRC Phosphorylation Unit staff
Year(s) Of Engagement Activity 2018
 
Description Media interviews 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Cold water swimming may protect the brain from degenerative diseases like dementia, researchers from Cambridge University have discovered.
Radio and TV interviews with BBC, news articles in the Independent and the Telegraph.
'Could cold water hold a clue to a dementia cure?'
https://www.bbc.co.uk/news/health-54531075
https://www.telegraph.co.uk/news/2020/10/19/cold-water-swimming-could-help-protect-dementia/ https://www.independent.co.uk/news/health/cold-water-swimming-dementia-cure-research-cambridge-university-b1152441.html
Year(s) Of Engagement Activity 2020
URL https://www.bbc.co.uk/news/health-54531075
 
Description Media interviews 2017-2021 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact I have discussed my research for lay audiences over the years on international and national television and radio (BBC, ITV, Channel 5, Sky, CNN, ABC, Al Jazeera; Radio 4 Today programme and World service; local radio stations) and to various national (Times, Telegraph, Guardian, Independent) and international newspapers and news agencies, and I have given interviews to the scientific press (including Nature, Science, Scientific American, New Scientist).
Year(s) Of Engagement Activity 2017,2018,2019,2020,2021
 
Description Neurodegenerative Diseases: Biology & Therapeutics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A primary goal of the meeting is to provide a forum where medical scientists from academia can interact with scientists from the biopharmaceutical industry, thus forging a community of academic and industry researchers who recognize that they have much to learn from each other. Rational drug discovery for neurodegenerative diseases has begun to yield compounds and treatments that are now entering clinical settings. For human studies utilizing these compounds and treatments to be maximally informative, it is crucial that scientists from academia and industry meet regularly to exchange data and ideas.

Professor Mallucci delivered a talk on: UPR activation in astrocytes induces non-cell autonomous neurotoxicity in neurodegenerative disease.
Year(s) Of Engagement Activity 2018
URL https://meetings.cshl.edu/meetings.aspx?meet=DEGEN&year=18
 
Description Old Age Psychiatry Meeting, Newmarket 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Invited to give a talk at the Old Age Psychiatry meeting on 12th February. Half an hour talk on translation.
Year(s) Of Engagement Activity 2020
 
Description Pamela MacKinnon Lecture: St Hilda's Medical Society Conference, "The Road to New Dementia Treatments" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact St Hilda's Medical Society Conference, 'Depths of the Mind: Exploring Issues in Mental Health', was a very warm reunion for our alumnae and alumni who read Medicine and Experimental Psychology and also current students and recent graduates.
Professor Giovanna Mallucci, Department of Clinical Neurosciences and Associate Director of the UK Dementia Research Institute at the University of Cambridge, gave the Pamela MacKinnon Lecture: The Road to New Dementia Treatments. Our alumna, Professor Mallucci, spoke of how her career had been inspired by Pamela MacKinnon and our Emeritus Fellow, Professor Jane Mellanby, who introduced her. Professor Mallucci shared groundbreaking research with the potential to lead to treatments to delay neuronal loss, which would allow people to stay at home for longer and help them to have meaningful lives.
Year(s) Of Engagement Activity 2018
URL https://www.sthildas.ox.ac.uk/sites/www.st-hildas.ox.ac.uk/files/Medical%20Society%20Conference%2020...
 
Description SONA Webinars 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Society of Neuroscientists of Africa SONA WEBINAR SERIES
Title: Mechanisms to Medicines in Neurodegeneration
Speaker: Prof. Giovanna Mallucci
Associate Director of the UK Dementia Research Institute
University of Cambridge, UK
Year(s) Of Engagement Activity 2019
URL https://www.youtube.com/watch?v=n0-OCVPP6EE
 
Description The 2017 UCD Conway Festival of Research & Innovation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact Below is a media report from the Conference which shows that (1) Giovanna Mallucci was THE presenter worth mentioning and (2) is able to instil major interest in her field.

"The 2017 UCD Conway Festival of Research & Innovation got under way last week with lectures and presentations by leading scientists from varied fields.
The festival, now in its seventeenth year, serves to highlight the substantial scientific research and innovation achievements being undertaken by the scientists and researchers of the UCD Conway Institute of Biomolecular and Biomedical Research. The annual event aims to celebrate the work that is going on at the moment with lectures from scientists from industry, academia, and clinical settings complemented with scientific talks, poster presentations and a career discussion forum for budding researchers.
"It's about linking ideas, linking people, getting discussions going and starting new collaborations" -

Topics covered ranged from cell signalling, cancer cell state maintenance, neurodegeneration, yeast evolution, comparative and integrative genomics, obesity, and botany.
Giovanna Mallucci from the Department of Clinical Neurosciences at Cambridge University gave superb insight into the mechanisms and possible treatment in neurodegenerative diseases in her lecture, 'Neurodegeneration: from molecules to medicines'. In her talk, Mallucci expressed how the combination of a decrease in synapse number and increase in the accumulation of misfolded proteins lead to neuronal loss."
Orla Daly - Science Editor
Year(s) Of Engagement Activity 2016,2017
 
Description The Edinburgh Parkinson's Lecture 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Guest Lecture: The Road to New Treatments for Dementia and Parkinson's

An audience of around 200 people, predominantly members of the Edinburgh Branch of Parkinson's UK, but including also many health professionals and researchers, came to the Queens Medical Research Institute, University of Edinburgh, to hear Giovanna Mallucci deliver the seventh annual Edinburgh Parkinson's Lecture.

Professor Mallucci answered questions from the audience, in a lively session chaired by Dr Conor Maguire. Themes included the importance of sleep in the maintenance of synaptic health and repair; the desirability of early intervention, although more will be known when clinical trials are underway about whether it is ever too late for treatment; the role of exercise in boosting synapses; and optimism about the future as new ways of slowing progress of dementia and Parkinson's are developed.
Year(s) Of Engagement Activity 2018
URL https://www.edinburghparkinsons.org/wp-content/uploads/2018/09/Mallucci-lecture-2018-1.pdf
 
Description The Scripps Research Institute, Neuroscience Seminar Series, University of California 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Scripps Research ranks as the most influential scientific organization in the world, unparalleled in propelling innovation in science and medicine. Their unique structure merges foundational studies in biology, chemistry and computer science with translational science to produce the next generation of drugs and advances in digital and precision medicine. Scientists in the institute's five academic research departments work hand-in-hand with researchers of the Scripps Research Translational Institute and Calibr. The neuroscience seminar series is designed to expose the graduate students to invited experts in their field from around the world to cultivate the next generation of scientific leaders and expand the frontiers of knowledge to drive innovation that improves lives around the planet.
Year(s) Of Engagement Activity 2019
 
Description Translating Translation: From Basic Mechanisms to Molecular Medicine - 38th Blankenese Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The Blankenese Conference focused on basic molecular mechanisms of mRNA translation will be brought together with those who study diseases where effects on translation are prominent. Its goal is to foster discussions between these groups. It will provide a perfect forum for advanced scientific exchange in these interconnected areas
Year(s) Of Engagement Activity 2018
 
Description UK-Japan Neuroscience Symposium, London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact This meeting will bring together leading neuroscientists from the UK and Japan to explore exciting new techniques in Neuroscience and ways in which new technologies and new methods of working can be applied to solving some of the most pressing health issues of our time such as dementia and mental health conditions.

Provided the plenary lecture, Cooling synapses: insights into neurodegeneration.
Year(s) Of Engagement Activity 2018
URL https://www.evensi.uk/uk-japan-neuroscience-symposium-royal-society-wolfson-library/238517176