Linking genetic, epidemiology and metabolic phenotyping in dementia in the context of aging, environment and lifestyle

Lead Research Organisation: Imperial College London

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The UK Dementia Research Institute (UK DRI) is an initiative funded by the Medical Research Council, Alzheimer's Society and Alzheimer's Research UK. Funding details for UK DRI programmes will be added in 2019.

Alzheimer’s disease (AD) is characterised by a prolonged pre-clinical phase involving Aß deposition but without the typical symptoms of cognitive impairment and frank dementia until relatively late on in the disease process. Though there is well described genetic predisposition to AD, most notably presence of the APOE e4 allele, known genetic factors to date explain only a small proportion of the variance in AD occurrence1. Little is known about the environmental, lifestyle and metabolic factors that, interacting with genetic background, determine who ultimately will go on to manifest clinical disease. Gaining knowledge of these risk factors is key to tackling the growing burden of AD, vascular and other dementias, as it offers the potential for lifestyle and preventive measures, and novel treatments, to delay or offset occurrence of clinical disease, with resultant gains in life expectancy and quality of life. This would be a major advance, since the current paradigm of diagnosis and treatment of overt disease is late, never-ending and largely
ineffective. Furthermore it is associated with poor quality of life, high burden for carers, and an ever
increasing cost for health services as the population ages. Reversing this trend by reducing the incidence and prevalence of dementia is an urgent priority.

Organisations

Publications

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Climaco Pinto R (2018) The Handbook of Metabolic Phenotyping

 
Description MRC Workshop on Supporting the development of future infrastructure for human phenotyping at depth and scale
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Uk Biobank Omics workshop - Determining opportunities and challenges of applying high throughut proteomic and metabolomic assays at scale in large population based prospective studies.
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Creating a national platform for molecular studies of multiple conditions: HDRUK multiomics consortium
Amount £1,088,606 (GBP)
Funding ID CFC0107 
Organisation Health Data Research UK 
Sector Private
Country United Kingdom
Start 03/2020 
End 03/2022
 
Description Harnessing diverse bioinformatics approaches to repurpose drugs for Alzheimer's disease
Amount $92,234 (USD)
Funding ID 1R56AG05063 
Organisation National Institutes of Health (NIH) 
Department National Institute on Aging
Sector Public
Country United States
Start 08/2017 
End 08/2018
 
Description Identification of Metabolic Phenotypes and Systemic Biochemical Reaction Networks Associated with Human Blood Pressure
Amount £331,486 (GBP)
Funding ID MR/S004033/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 02/2018 
End 02/2021
 
Description REACT Long COVID (REACT-LC)
Amount £5,436,399 (GBP)
Funding ID COV-LT-0040 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 03/2023 
End 02/2024
 
Description REACT-GE: Multi-omics to identify biological pathways underlying severity of SARS-CoV-2 infection
Amount £2,125,587 (GBP)
Funding ID MR/V030841/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 08/2020 
End 06/2021
 
Description APoE polymorphisms project 
Organisation University of Aberdeen
Department The Rowett Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Expertise in metabolomics pathway data analysis
Collaborator Contribution Use of metabolomics and lipidomics to understand underlying mechanisms of disease and experience in cell culture and animal studies
Impact ongoing collaboration
Start Year 2020
 
Description Air pollution and cognition project 
Organisation Imperial College London
Department School of Public Health
Country United Kingdom 
Sector Academic/University 
PI Contribution Epidemiological expertise, epidemiological cohort data
Collaborator Contribution Air polllution modelling and measurement, in-depth knowledge of health impacts of ULEZ
Impact Current grant collaboration
Start Year 2020
 
Description Airwave and CCACE - Centre for Cognitive Ageing and Cognitive Epidemiology 
Organisation University of Edinburgh
Department MRC Centre for Cognitive Ageing and Cognitive Epidemiology
Country United Kingdom 
Sector Academic/University 
PI Contribution Data collection, data quality control and analysis and database management
Collaborator Contribution Working with to enhancement baseline data collection with addition of questions on mental health and cognition to enable future analysis of work-related stressors
Impact ongoing collaboration
Start Year 2018
 
Description Airwave collaboration with DPUK - shift work and cognitive function 
Organisation MRC Dementias Platform UK
Country United Kingdom 
Sector Academic/University 
PI Contribution Work on how disruption of circadian rhythms due to shift work may be associated with various health disorders including psychological health, bringing cohort data and epidemiological expertise to the collaboration
Collaborator Contribution DPUK facilitates meta-analysis using data from various cohorts.
Impact ongoing collaboration
Start Year 2018
 
Description Airwave study - collaboration - mitochondrial disfunction project 
Organisation MRC Dementias Platform UK
Country United Kingdom 
Sector Academic/University 
PI Contribution Work to assess cognitive function through analysis of Airwave cohort study blood samples - team brings data and statistical analysis skills
Collaborator Contribution DPUK facilitates use of cohort data for epidemiological analysis
Impact ongoing collaboration
Start Year 2018
 
Description Alcohol intake and brain and cardiovascular structure project 
Organisation University of Ioannina
Department Department of Hygiene and Epidemiology
Country Greece 
Sector Academic/University 
PI Contribution Epidemiological expertise, effects of alcohol drinking on health
Collaborator Contribution Expertise in GWAS and meta-analysis
Impact manuscript under submission
Start Year 2020
 
Description Alcohol intake and brain, cardiac, aortic and liver MRI 
Organisation Brunel University London
Country United Kingdom 
Sector Academic/University 
PI Contribution Study concept and analytical supervision, critical review of data interpretation
Collaborator Contribution Ioannina - GWAS analysis; drafting manuscript; Tohoku - data processing & statistical analysis
Impact Paper published Evangelou E et al. eLife 2021 Jun 10:e65325 doi: 10.7554/eLife.65325.
Start Year 2019
 
Description Alcohol intake and brain, cardiac, aortic and liver MRI 
Organisation Tohoku University Hospital
Country Japan 
Sector Hospitals 
PI Contribution Study concept and analytical supervision, critical review of data interpretation
Collaborator Contribution Ioannina - GWAS analysis; drafting manuscript; Tohoku - data processing & statistical analysis
Impact Paper published Evangelou E et al. eLife 2021 Jun 10:e65325 doi: 10.7554/eLife.65325.
Start Year 2019
 
Description Alcohol intake and brain, cardiac, aortic and liver MRI 
Organisation University of Ioannina
Department Department of Hygiene and Epidemiology
Country Greece 
Sector Academic/University 
PI Contribution Study concept and analytical supervision, critical review of data interpretation
Collaborator Contribution Ioannina - GWAS analysis; drafting manuscript; Tohoku - data processing & statistical analysis
Impact Paper published Evangelou E et al. eLife 2021 Jun 10:e65325 doi: 10.7554/eLife.65325.
Start Year 2019
 
Description Alcohol-related genes and neuropsychiatric disorders 
Organisation King's College London
Department Institute of Psychiatry, Psychology & Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution Study design and concept; supervision of data analysis; epidemiological interpretation of data results; critical review of manuscript
Collaborator Contribution Ioannina - GWAS analysis, drafting of paper; IOP KCL - expertise in health effects of alcohol consumption, and psychiatric disorders
Impact Published paper Evangelou et al Nature Human Behaviour 2019
Start Year 2018
 
Description Alcohol-related genes and neuropsychiatric disorders 
Organisation University of Ioannina
Department Department of Hygiene and Epidemiology
Country Greece 
Sector Academic/University 
PI Contribution Study design and concept; supervision of data analysis; epidemiological interpretation of data results; critical review of manuscript
Collaborator Contribution Ioannina - GWAS analysis, drafting of paper; IOP KCL - expertise in health effects of alcohol consumption, and psychiatric disorders
Impact Published paper Evangelou et al Nature Human Behaviour 2019
Start Year 2018
 
Description Alzheimer's Disease risk loci - functional annotation 
Organisation Cardiff University
Department School of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Exploring collaboration on using multiplex modelling rechniques developed by the Cardiff research group for functional annotation of AD risk loci and understanding downstream mechanisms.
Collaborator Contribution Recent work on single-cell sequencing of Dopamine neurons and related work is of interest to our DRI group and may have applications in the data sets that we are currently analysing.
Impact new ongoing collaboration
Start Year 2021
 
Description Aortic traits and cerebrovascular disease 
Organisation Duke-NUS Graduate Medical School
Department Microbiology Duke-NUS
Country United States 
Sector Academic/University 
PI Contribution Knowledge of UK Biobank cardiac magnetic resonance imaging (CMR) and GWAS data analysis and Mendelian Randomization analytic approach.
Collaborator Contribution NHLI - expertise in vascular biology (lead author), Bordeaux - brain imaging markers of cognitive decline and dementias, Texas - cerebrovascular disease, Duke NUS - genetic regulation of molecular pathways and gene networks.
Impact Publication Francis C et al. 2021 MedRxiv https://doi.org/10.1101/2021.09.01.21262202
Start Year 2020
 
Description Aortic traits and cerebrovascular disease 
Organisation Imperial College London
Department National Heart & Lung Institute (NHLI)
Country United Kingdom 
Sector Academic/University 
PI Contribution Knowledge of UK Biobank cardiac magnetic resonance imaging (CMR) and GWAS data analysis and Mendelian Randomization analytic approach.
Collaborator Contribution NHLI - expertise in vascular biology (lead author), Bordeaux - brain imaging markers of cognitive decline and dementias, Texas - cerebrovascular disease, Duke NUS - genetic regulation of molecular pathways and gene networks.
Impact Publication Francis C et al. 2021 MedRxiv https://doi.org/10.1101/2021.09.01.21262202
Start Year 2020
 
Description Aortic traits and cerebrovascular disease 
Organisation National Institute of Health and Medical Research (INSERM)
Department Bordeaux
Country France 
Sector Public 
PI Contribution Knowledge of UK Biobank cardiac magnetic resonance imaging (CMR) and GWAS data analysis and Mendelian Randomization analytic approach.
Collaborator Contribution NHLI - expertise in vascular biology (lead author), Bordeaux - brain imaging markers of cognitive decline and dementias, Texas - cerebrovascular disease, Duke NUS - genetic regulation of molecular pathways and gene networks.
Impact Publication Francis C et al. 2021 MedRxiv https://doi.org/10.1101/2021.09.01.21262202
Start Year 2020
 
Description Aortic traits and cerebrovascular disease 
Organisation The University of Texas Health Science Center
Country United States 
Sector Academic/University 
PI Contribution Knowledge of UK Biobank cardiac magnetic resonance imaging (CMR) and GWAS data analysis and Mendelian Randomization analytic approach.
Collaborator Contribution NHLI - expertise in vascular biology (lead author), Bordeaux - brain imaging markers of cognitive decline and dementias, Texas - cerebrovascular disease, Duke NUS - genetic regulation of molecular pathways and gene networks.
Impact Publication Francis C et al. 2021 MedRxiv https://doi.org/10.1101/2021.09.01.21262202
Start Year 2020
 
Description BHF Imperial College Centre for Research Excellence - collaboration 
Organisation Imperial College London
Department British Heart Foundation Centre of Research Excellence
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Expertise in applying 'big data' approaches to investigate shared genetic and non-genetic risk factors between cardiovascular and neurodegerative diseases
Collaborator Contribution Expertise and potentially funding for geneticist with the DRI to investigate common pathways, and shared pathways to structural and functional effects on brain and heart/vasculature from imaging data
Impact new collaboration
Start Year 2020
 
Description Blood pressure traits project in UK Biobank and ICBP data 
Organisation Broad Institute
Country United States 
Sector Charity/Non Profit 
PI Contribution UKB data acquisition; contributed cohort data to GWAS analysis, epidemiological interpretation of results, reviewed and edited manuscript
Collaborator Contribution Ioannina - led GWAS analysis and drafted manuscript; Broad Inst - hosted data; QMUL - contributed ICBP data to analysis; critical data interpretation
Impact Published paper Evangelou et al Nature Genetics 2018 and continuing collaboration
Start Year 2018
 
Description Blood pressure traits project in UK Biobank and ICBP data 
Organisation Queen Mary University of London
Department William Harvey Research Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution UKB data acquisition; contributed cohort data to GWAS analysis, epidemiological interpretation of results, reviewed and edited manuscript
Collaborator Contribution Ioannina - led GWAS analysis and drafted manuscript; Broad Inst - hosted data; QMUL - contributed ICBP data to analysis; critical data interpretation
Impact Published paper Evangelou et al Nature Genetics 2018 and continuing collaboration
Start Year 2018
 
Description Blood pressure traits project in UK Biobank and ICBP data 
Organisation University of Ioannina
Department Department of Hygiene and Epidemiology
Country Greece 
Sector Academic/University 
PI Contribution UKB data acquisition; contributed cohort data to GWAS analysis, epidemiological interpretation of results, reviewed and edited manuscript
Collaborator Contribution Ioannina - led GWAS analysis and drafted manuscript; Broad Inst - hosted data; QMUL - contributed ICBP data to analysis; critical data interpretation
Impact Published paper Evangelou et al Nature Genetics 2018 and continuing collaboration
Start Year 2018
 
Description Brain ageing project 
Organisation Middlesex University
Country United Kingdom 
Sector Academic/University 
PI Contribution Study design, developed methods, analysed and interpreted the data and PhD student drafted paper.
Collaborator Contribution Expertise in machine learning and its interface with signal processing and high-dimensional statistics, Models and algorithms for learning from high-dimensional data.
Impact PhD student thesis and paper. Kolbeinsson et al . doi:10.1038/s41598-020-76518-z
Start Year 2020
 
Description CHARGE Consortium - collaboration - Cohorts for Heart and Aging Research in Genomic Epidemiology 
Organisation Erasmus MC
Country Netherlands 
Sector Hospitals 
PI Contribution Contributing cohort data and epidemiological expertise, membership of steering committee and participated in scientific meetings, as part of joint collaboration and pooling of data for analysis.
Collaborator Contribution Consortium facilitates genome wide association meta-analysis and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies and brings knowledge and skills in neuroscience, dementias and age-related diseases
Impact continuing collaboration and planned joint publications
Start Year 2017
 
Description CHARGE Consortium - collaboration - Cohorts for Heart and Aging Research in Genomic Epidemiology 
Organisation Kaiser Permanente Washington Health Research Institute
Country United States 
Sector Hospitals 
PI Contribution Contributing cohort data and epidemiological expertise, membership of steering committee and participated in scientific meetings, as part of joint collaboration and pooling of data for analysis.
Collaborator Contribution Consortium facilitates genome wide association meta-analysis and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies and brings knowledge and skills in neuroscience, dementias and age-related diseases
Impact continuing collaboration and planned joint publications
Start Year 2017
 
Description CHARGE Consortium - collaboration - Cohorts for Heart and Aging Research in Genomic Epidemiology 
Organisation National Institutes of Health (NIH)
Department National Heart, Lung, and Blood Institute (NHLBI)
Country United States 
Sector Public 
PI Contribution Contributing cohort data and epidemiological expertise, membership of steering committee and participated in scientific meetings, as part of joint collaboration and pooling of data for analysis.
Collaborator Contribution Consortium facilitates genome wide association meta-analysis and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies and brings knowledge and skills in neuroscience, dementias and age-related diseases
Impact continuing collaboration and planned joint publications
Start Year 2017
 
Description CHARGE Consortium - collaboration - Cohorts for Heart and Aging Research in Genomic Epidemiology 
Organisation National Institutes of Health (NIH)
Department National Institute on Aging
Country United States 
Sector Public 
PI Contribution Contributing cohort data and epidemiological expertise, membership of steering committee and participated in scientific meetings, as part of joint collaboration and pooling of data for analysis.
Collaborator Contribution Consortium facilitates genome wide association meta-analysis and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies and brings knowledge and skills in neuroscience, dementias and age-related diseases
Impact continuing collaboration and planned joint publications
Start Year 2017
 
Description CHARGE Consortium - collaboration - Cohorts for Heart and Aging Research in Genomic Epidemiology 
Organisation University of Massachusetts
Country United States 
Sector Academic/University 
PI Contribution Contributing cohort data and epidemiological expertise, membership of steering committee and participated in scientific meetings, as part of joint collaboration and pooling of data for analysis.
Collaborator Contribution Consortium facilitates genome wide association meta-analysis and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies and brings knowledge and skills in neuroscience, dementias and age-related diseases
Impact continuing collaboration and planned joint publications
Start Year 2017
 
Description Cardiff - ABCA7 modelling collaboration 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Metabolomics data analysis by the team and epidemiological and statistical skills to interpret the data
Collaborator Contribution Working on a ABCA7 knockout fruit fly model to validate metabolomics findings
Impact ongoing collaboration
Start Year 2019
 
Description Ceramide metabolism project (ABCA7) 
Organisation Erasmus MC
Country Netherlands 
Sector Hospitals 
PI Contribution Experience of conducting metabolome-wide association study (MWAS) of AD-associated loci from GWAS using metabolic profiling (metabolomics)
Collaborator Contribution Geriatrics and specialist knowledge in AD and dementias (Karolinska), brain ageing and neuroepidemiology (Erasmus), cellular neuroscience (Mayo)
Impact Publication by Dehghan A et al 2021 Medrxiv doi: https://doi.org/10.1101/2021.04.06.21254991
Start Year 2020
 
Description Ceramide metabolism project (ABCA7) 
Organisation Karolinska Institute
Department Department of Clinical Neuroscience
Country Sweden 
Sector Academic/University 
PI Contribution Experience of conducting metabolome-wide association study (MWAS) of AD-associated loci from GWAS using metabolic profiling (metabolomics)
Collaborator Contribution Geriatrics and specialist knowledge in AD and dementias (Karolinska), brain ageing and neuroepidemiology (Erasmus), cellular neuroscience (Mayo)
Impact Publication by Dehghan A et al 2021 Medrxiv doi: https://doi.org/10.1101/2021.04.06.21254991
Start Year 2020
 
Description Ceramide metabolism project (ABCA7) 
Organisation Karolinska Institute
Country Sweden 
Sector Academic/University 
PI Contribution Epidemiological expertise, study design and methodology, experience of MWAS, samples from Airwave study
Collaborator Contribution Expertise in metabolomics and interpretation of metabolomic signatures, mass spectrometry data (Murdoch); AD mechanisms (E Finland); samples from FINGER Trial (Karolinska)
Impact Ongoing collaboration and paper for publication in preparation
Start Year 2019
 
Description Ceramide metabolism project (ABCA7) 
Organisation Mayo Clinic
Department Department of Neuroscience
Country United States 
Sector Hospitals 
PI Contribution Experience of conducting metabolome-wide association study (MWAS) of AD-associated loci from GWAS using metabolic profiling (metabolomics)
Collaborator Contribution Geriatrics and specialist knowledge in AD and dementias (Karolinska), brain ageing and neuroepidemiology (Erasmus), cellular neuroscience (Mayo)
Impact Publication by Dehghan A et al 2021 Medrxiv doi: https://doi.org/10.1101/2021.04.06.21254991
Start Year 2020
 
Description Ceramide metabolism project (ABCA7) 
Organisation Murdoch University
Country Australia 
Sector Academic/University 
PI Contribution Epidemiological expertise, study design and methodology, experience of MWAS, samples from Airwave study
Collaborator Contribution Expertise in metabolomics and interpretation of metabolomic signatures, mass spectrometry data (Murdoch); AD mechanisms (E Finland); samples from FINGER Trial (Karolinska)
Impact Ongoing collaboration and paper for publication in preparation
Start Year 2019
 
Description Ceramide metabolism project (ABCA7) 
Organisation University of Eastern Finland
Country Finland 
Sector Academic/University 
PI Contribution Epidemiological expertise, study design and methodology, experience of MWAS, samples from Airwave study
Collaborator Contribution Expertise in metabolomics and interpretation of metabolomic signatures, mass spectrometry data (Murdoch); AD mechanisms (E Finland); samples from FINGER Trial (Karolinska)
Impact Ongoing collaboration and paper for publication in preparation
Start Year 2019
 
Description DRI - collaboration on alcohol genome wide association study 
Organisation King's College London
Department Institute of Psychiatry, Psychology & Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution Expertise in cohort data analysis and GWAS
Collaborator Contribution Expertise in health effects of alcohol and in genetic epidemiology
Impact in progress
Start Year 2017
 
Description DRI - collaboration with ARIC study investigators - on neurocognitive study 
Organisation University of North Carolina at Chapel Hill
Country United States 
Sector Academic/University 
PI Contribution Expertise in population cohort studies
Collaborator Contribution Study data and samples for analysis
Impact in progress
Start Year 2017
 
Description DRI - collaboration with CARDIA study investigators 
Organisation University of North Carolina at Chapel Hill
Country United States 
Sector Academic/University 
PI Contribution Expertise in metabolomics and molecular epidemiology
Collaborator Contribution Study data and samples
Impact in progress
Start Year 2017
 
Description DRI - collaboration with FINGER study investigators 
Organisation Karolinska Institute
Country Sweden 
Sector Academic/University 
PI Contribution Expertise in molecular epidemiology and metabolomics and metabolic phenotyping
Collaborator Contribution FINGER Trial Study data and samples and expertise in neuroscience
Impact in progress
Start Year 2017
 
Description DRI - collaboration with FINGER study investigators 
Organisation National Institute for Health and Welfare
Country Finland 
Sector Public 
PI Contribution Expertise in molecular epidemiology and metabolomics and metabolic phenotyping
Collaborator Contribution FINGER Trial Study data and samples and expertise in neuroscience
Impact in progress
Start Year 2017
 
Description DRI - collaboration with MEMENTO investigators 
Organisation University of Bordeaux
Country France 
Sector Academic/University 
PI Contribution Expertise in design and management of longitudinal epidemiological cohort studies
Collaborator Contribution Expertise in investigation of biomarkers for Alzheimer's disease and related conditions
Impact in progress
Start Year 2017
 
Description DRI - collaboration with MESA study investigators 
Organisation Wake Forest University
Country United States 
Sector Academic/University 
PI Contribution Expertise in metabolomics and epidemiology
Collaborator Contribution Has established Alzheimer's Disease Core Centre at Wake Forest with associated faculty and resources
Impact in progress
Start Year 2017
 
Description DRI - collaboration with UK Biobank 
Organisation UK Biobank
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Expertise in metabolomics analysis
Collaborator Contribution UK Biobank data/samples
Impact in progress
Start Year 2017
 
Description Dopaminergic neurodegeneration and Parkinsons project 
Organisation National Institutes of Health (NIH)
Department National Institute on Aging
Country United States 
Sector Public 
PI Contribution Expertise in clinical pharmacology and therapeutics; and in quantitative genetics and genome analysis
Collaborator Contribution Expertise in genomics, gene editing and drug repurposing. Experience in use of computational tools to analyse large human genetic datasets.
Impact Publication Wainberg M et l 2021 MedRxiv doi: https://doi.org/10.1101/2020.05.06.20089748
Start Year 2020
 
Description Dopaminergic neurodegeneration and Parkinsons project 
Organisation Stanford University
Country United States 
Sector Academic/University 
PI Contribution Expertise in clinical pharmacology and therapeutics; and in quantitative genetics and genome analysis
Collaborator Contribution Expertise in genomics, gene editing and drug repurposing. Experience in use of computational tools to analyse large human genetic datasets.
Impact Publication Wainberg M et l 2021 MedRxiv doi: https://doi.org/10.1101/2020.05.06.20089748
Start Year 2020
 
Description Drug repurposing research project 
Organisation Harvard University
Department Harvard T.H. Chan School of Public Health
Country United States 
Sector Academic/University 
PI Contribution Researching associations between currently approved drugs and risk of dementias as part of drug repurposing research programme
Collaborator Contribution Harvard - knowledge of genetics of neuro-epidemiology and MIT - statistical modelling skills
Impact ongoing collaboration
Start Year 2019
 
Description Drug repurposing research project 
Organisation Massachusetts Institute of Technology
Country United States 
Sector Academic/University 
PI Contribution Researching associations between currently approved drugs and risk of dementias as part of drug repurposing research programme
Collaborator Contribution Harvard - knowledge of genetics of neuro-epidemiology and MIT - statistical modelling skills
Impact ongoing collaboration
Start Year 2019
 
Description FINGER Trial collaboration - Association of metabolomics with cognition 
Organisation Karolinska Institute
Department Department of Public Health Sciences
Country Sweden 
Sector Academic/University 
PI Contribution Analysis of metabolomics data and data interpretation - based on data from the FINGER Trial made available by study partners
Collaborator Contribution Data from the FINGER Trial and expertise in biomarkers for cognition
Impact Work in progress aiming for paper for publication
Start Year 2020
 
Description FINGER Trial collaboration - Association of metabolomics with cognition 
Organisation University of Ioannina
Department Department of Hygiene and Epidemiology
Country Greece 
Sector Academic/University 
PI Contribution Analysis of metabolomics data and data interpretation - based on data from the FINGER Trial made available by study partners
Collaborator Contribution Data from the FINGER Trial and expertise in biomarkers for cognition
Impact Work in progress aiming for paper for publication
Start Year 2020
 
Description Gene and educational attainment and BP project 
Organisation University of Washington
Country United States 
Sector Academic/University 
PI Contribution Airwave cohort samples for genome-wide meta-analysis, data provision
Collaborator Contribution Study design and conducted meta-analysis
Impact Published paper de las Fuentes et al 2020 Mol Psychiatry
Start Year 2019
 
Description Gene-smoking interactions and blood pressure 
Organisation University of Texas
Department Health Science Center at Houston
Country United States 
Sector Academic/University 
PI Contribution Contributed Airwave cohort data, epidemiological data interpretation, critical review of manuscripts
Collaborator Contribution conducted GWAS data analysis, Contributed data - multiple consortia
Impact Published papers Sung Y et al Am J Hum Genetics 2018 and Sung Y et al Hum Mol Genetics 2019;
Start Year 2018
 
Description Gene-smoking interactions and blood pressure 
Organisation Washington University School of Medicine
Country United States 
Sector Academic/University 
PI Contribution Contributed Airwave cohort data, epidemiological data interpretation, critical review of manuscripts
Collaborator Contribution conducted GWAS data analysis, Contributed data - multiple consortia
Impact Published papers Sung Y et al Am J Hum Genetics 2018 and Sung Y et al Hum Mol Genetics 2019;
Start Year 2018
 
Description Genetic predisposition to higher BP and risk of stroke 
Organisation Ludwig Maximilian University of Munich (LMU Munich)
Country Germany 
Sector Academic/University 
PI Contribution Experience of GWAS analysis of UK Biobank and ICBP data and expertise in the application of Mendelian Randomization analytic techniques.
Collaborator Contribution Knowledge of cerebral small vessel disease and stroke sub-types and associations with dementias (lead author - Ludwig-Maximilians), role of antithrombotic drugs in preventing stroke, differences between stroke subtypes, and genes that influence stroke (Edinburgh), cerebrovascular physiology and risk of stroke (Oxford).
Impact Publication Georgiakis et al Neurology 2020 Jul 28; 95(4): e353-e361.
Start Year 2020
 
Description Genetic predisposition to higher BP and risk of stroke 
Organisation University of Edinburgh
Department Institute of Genetics & Molecular Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Experience of GWAS analysis of UK Biobank and ICBP data and expertise in the application of Mendelian Randomization analytic techniques.
Collaborator Contribution Knowledge of cerebral small vessel disease and stroke sub-types and associations with dementias (lead author - Ludwig-Maximilians), role of antithrombotic drugs in preventing stroke, differences between stroke subtypes, and genes that influence stroke (Edinburgh), cerebrovascular physiology and risk of stroke (Oxford).
Impact Publication Georgiakis et al Neurology 2020 Jul 28; 95(4): e353-e361.
Start Year 2020
 
Description Genetic predisposition to higher BP and risk of stroke 
Organisation University of Oxford
Department Nuffield Department of Clinical Neurosciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Experience of GWAS analysis of UK Biobank and ICBP data and expertise in the application of Mendelian Randomization analytic techniques.
Collaborator Contribution Knowledge of cerebral small vessel disease and stroke sub-types and associations with dementias (lead author - Ludwig-Maximilians), role of antithrombotic drugs in preventing stroke, differences between stroke subtypes, and genes that influence stroke (Edinburgh), cerebrovascular physiology and risk of stroke (Oxford).
Impact Publication Georgiakis et al Neurology 2020 Jul 28; 95(4): e353-e361.
Start Year 2020
 
Description Inflammatory pathways project 
Organisation Imperial College London
Department Department of Metabolism, Digestion and Reproduction
Country United Kingdom 
Sector Academic/University 
PI Contribution Epidemiological expertise, metabolomics data interpretation
Collaborator Contribution Expertise in inflammatory lipidomics
Impact ongoing collaboration
Start Year 2019
 
Description Inflammatory pathways project 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Epidemiological expertise, metabolomics data interpretation
Collaborator Contribution Expertise in inflammatory lipidomics
Impact ongoing collaboration
Start Year 2019
 
Description KU Leuven - APOE collaboration 
Organisation University of Leuven
Country Belgium 
Sector Academic/University 
PI Contribution Metabolomics data analysis and statistical and epidemiological skills to interpret the data
Collaborator Contribution Laboratory facilities to follow up and validate metabolomics findings in APOE knockout models and skills to interpret the results
Impact ongoing collaboration
Start Year 2019
 
Description Metabolic markers of cognitive change in the FINGER trial 
Organisation Karolinska Institute
Country Sweden 
Sector Academic/University 
PI Contribution Skills and expertise in epidemiological and metabolomics analysis, modelling and interpretation of results for identification of metabolic biomarkers associated with cognitive function and later life health outcomes.
Collaborator Contribution Providing data from the FINGER clinical trial and expertise in dementias and ageing research.
Impact ongoing collaboration
Start Year 2019
 
Description Metabolic markers of cognitive change in the FINGER trial 
Organisation National Institute for Health and Welfare
Country Finland 
Sector Public 
PI Contribution Skills and expertise in epidemiological and metabolomics analysis, modelling and interpretation of results for identification of metabolic biomarkers associated with cognitive function and later life health outcomes.
Collaborator Contribution Providing data from the FINGER clinical trial and expertise in dementias and ageing research.
Impact ongoing collaboration
Start Year 2019
 
Description Metabolomic and epigenetic ageing project 
Organisation University of Oulu
Department Biocenter Oulu
Country Finland 
Sector Academic/University 
PI Contribution Study concept and design, data curation and analysis, AIRWAVE data acquisition, drafted paper
Collaborator Contribution Data and metabolomic analysis of NFBC cohort
Impact Published paper Robinson O et al. Ageing Cell doi: 10.1111/acel.13149
Start Year 2020
 
Description Methods development - identification of correspondence between metabolomics features in similar LC-MS datasets 
Organisation Erasmus MC
Country Netherlands 
Sector Hospitals 
PI Contribution Analysis and integration of datasets from study partners and data interpretation of annotated metabolomics features. Aim to develop freely available software for dissemination.
Collaborator Contribution Contributing individual datasets for analysis and comparison e.g. from Rotterdam Study.
Impact Paper under revision with scientific journal
Start Year 2020
 
Description Methods development - identification of correspondence between metabolomics features in similar LC-MS datasets 
Organisation Great Ormond Street Hospital (GOSH)
Country United Kingdom 
Sector Hospitals 
PI Contribution Analysis and integration of datasets from study partners and data interpretation of annotated metabolomics features. Aim to develop freely available software for dissemination.
Collaborator Contribution Contributing individual datasets for analysis and comparison e.g. from Rotterdam Study.
Impact Paper under revision with scientific journal
Start Year 2020
 
Description Methods development - identification of correspondence between metabolomics features in similar LC-MS datasets 
Organisation Wake Forest University
Country United States 
Sector Academic/University 
PI Contribution Analysis and integration of datasets from study partners and data interpretation of annotated metabolomics features. Aim to develop freely available software for dissemination.
Collaborator Contribution Contributing individual datasets for analysis and comparison e.g. from Rotterdam Study.
Impact Paper under revision with scientific journal
Start Year 2020
 
Description Multi-omic blood pressure GWAS study 
Organisation VA Boston Healthcare System
Department Massachusetts Veterans Epidemiology Research and Information Center
Country United States 
Sector Public 
PI Contribution Expertise in blood pressure GWAS analysis and UK Biobank data; epidemiological interpretation of data analysis results
Collaborator Contribution Project coordination, GWAS analysis
Impact Published paper Giri et al Nature Genetics 2019
Start Year 2019
 
Description Multi-omic blood pressure GWAS study 
Organisation Vanderbilt University
Department Vanderbilt Medical Center
Country United States 
Sector Academic/University 
PI Contribution Expertise in blood pressure GWAS analysis and UK Biobank data; epidemiological interpretation of data analysis results
Collaborator Contribution Project coordination, GWAS analysis
Impact Published paper Giri et al Nature Genetics 2019
Start Year 2019
 
Description Multi-omics pathway analysis 
Organisation University of Cambridge
Department Cambridge Systems Biology Centre (CSBC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Analysis of multi-omic datasets and multivariate statistical analysis.
Collaborator Contribution Expertise in metaboloimics and lipidomics and use of animal models
Impact Publication by Marcia-Segura M et al MedRxiv 2021 doi: https://doi.org/10.1101/2021.05.10.21255052
Start Year 2020
 
Description Novel method for proteomics and metabolomics analysis of biological samples 
Organisation Virginia Polytechnique Institute and State University
Country United States 
Sector Academic/University 
PI Contribution Metabolomics statistical analysis, development of data processing methodology
Collaborator Contribution Access to MESA cohort dataset; project concept and supervision
Impact Publication Wu et al Bioinformatics 2020
Start Year 2019
 
Description Novel method for proteomics and metabolomics analysis of biological samples 
Organisation Wake Forest University
Department Wake Forest School of Medicine
Country United States 
Sector Academic/University 
PI Contribution Metabolomics statistical analysis, development of data processing methodology
Collaborator Contribution Access to MESA cohort dataset; project concept and supervision
Impact Publication Wu et al Bioinformatics 2020
Start Year 2019
 
Description REACT-Genomics England project 
Organisation Genomics England
Country United Kingdom 
Sector Public 
PI Contribution Data and resources from the REACT COVID-19 project and epidemiological expertise
Collaborator Contribution Data and resources and expertise from the GenoMICC Consortium
Impact Grant recently active and project recruiting
Start Year 2020
 
Description Serum metabolic signatures of coronary and carotid atherosclerosis 
Organisation Paul Sabatier University (University of Toulouse III)
Country France 
Sector Academic/University 
PI Contribution Study supervision; expertise in interpretation of metabolomic data
Collaborator Contribution Project data from cohort studies and advice on clinical aspects of atherosclerosis and cardiovascular disease
Impact Published paper Tzoulaki et al European Heart Journal 2019
Start Year 2018
 
Description Serum metabolic signatures of coronary and carotid atherosclerosis 
Organisation University of Ioannina
Department Department of Hygiene and Epidemiology
Country Greece 
Sector Academic/University 
PI Contribution Study supervision; expertise in interpretation of metabolomic data
Collaborator Contribution Project data from cohort studies and advice on clinical aspects of atherosclerosis and cardiovascular disease
Impact Published paper Tzoulaki et al European Heart Journal 2019
Start Year 2018
 
Description Serum metabolic signatures of coronary and carotid atherosclerosis 
Organisation Wake Forest University
Department Wake Forest School of Medicine
Country United States 
Sector Academic/University 
PI Contribution Study supervision; expertise in interpretation of metabolomic data
Collaborator Contribution Project data from cohort studies and advice on clinical aspects of atherosclerosis and cardiovascular disease
Impact Published paper Tzoulaki et al European Heart Journal 2019
Start Year 2018
 
Description Stanford - collaboration 
Organisation Stanford University
Country United States 
Sector Academic/University 
PI Contribution Working on examination of drugs for treatment of ADHD and risk of neurodegenerative diseases, bringing skills in genetic epidemiology, genome-wide association data analysis and interpretation
Collaborator Contribution Expertise in developing statistical methods and computational tools for analysis of large human genetic data
Impact ongoing
Start Year 2019
 
Description Stroke and dementias project 
Organisation Ludwig-Maximilians-University Hospital
Country Germany 
Sector Hospitals 
PI Contribution Data acquisition and analysis and interpretation
Collaborator Contribution Expertise in stroke cerebral small vessel disease, cardiovascular genetics, Mendelian randomization & epidemiology
Impact Published paper Georgakis et al Neurology doi: 10.1212/WNL.0000000000009814
Start Year 2020
 
Description UK DRI Wisconsin collaboration 
Organisation University of Wisconsin-Madison
Country United States 
Sector Academic/University 
PI Contribution Expertise in metabolomics analysis and cardio-metabolic health risk factors
Collaborator Contribution Potential contribution of data from the Wisconsin Registry for Alzheimer's Prevention cohort study and expertise in analysis of clinical patient data and geriatric research.
Impact ongoing collaboration
Start Year 2019
 
Description UK DRI and CHARIOT patient register collaboration 
Organisation Imperial College Healthcare NHS Trust
Country United Kingdom 
Sector Hospitals 
PI Contribution Expertise in epidemiology of patient cohorts and metabolomics and genome wide association studies
Collaborator Contribution Data collection in the CHARIOT patient register and expertise in elderly/geriatric clinical epidemiology and diseases of later life including dementias.
Impact new ongoing collaboration
Start Year 2020
 
Description UKB 18545 - Health effects of high blood pressure on brain function and microstructure 
Organisation Imperial College London
Department MRC London Institute of Medical Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Epidemiological expertise for data analysis and knowledge of UK Biobank cohort
Collaborator Contribution Expertise in cardiac imaging and neuroscience
Impact previous output of this collaboration was Suzuki H et al. PLoS One 2017. Nov 16;12(11):e0187600. doi: 10.1371/journal.pone.0187600 next paper in preparation
Start Year 2019
 
Description Alzheimer's Society Round Table discussion on Air pollution and Dementia - invited participation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invitation to contribute to round table discussion which aimed to debate the current scientific evidence with a view to informing the Society's position on the topic.
Year(s) Of Engagement Activity 2019
 
Description Conference poster presentation - Metabolomics Society Conference June 2021 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster presentation on Integration and Visualisation of Multiple Metabolomics Datasets with UMAP. Development of UMAP technique to integrate and harmonize metabolomics features identified by multiple different platforms and sources- stimulated discussion and interest in new methods for data visualisation.
Year(s) Of Engagement Activity 2021
 
Description Conference presentation to 2021 Alzheimer's Society International Conference (virtual) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on Metabolomics analysis of the Finnish Geriatric Intervention Study to prevent cognitive impairment and disability (FINGER) part of our UK DRI collaboration.
Year(s) Of Engagement Activity 2021
URL https://alz.confex.com/alz/2021/meetingapp.cgi/Paper/56390
 
Description Invited oral presentation at British Cardiac Society Annual Conference 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on "Exploiting the metabolome in cardiovascular disease" talking about how using metabolic profiling on epidemiology and clinical data offers new opportunities to discover causes and mechanisms of disease and identify new biomarkers for diseases. Audience was attending the British Heart Foundation Bench-to-Bedside: Towards New Treatments and Biomarkers session and included clinicians, academics, patient group organisations and students, and there was a moderated questions session at the end.
Year(s) Of Engagement Activity 2019
 
Description Neurofilaments as a biomarker - Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact On Friday 16 November 2018, over 50 speakers and delegates attended a workshop convened by Professor Paul Matthews (Imperial College London) and Professor Henrik Zetterberg (UCL) at 58 Prince's Gate, South Kensington, London.

The workshop, sponsored by Biogen, was a huge success with excellent engagement and discussion throughout the day.
Year(s) Of Engagement Activity 2018
URL https://www.imperial.ac.uk/dementia-research-institute/seminars--events/past-events/neurofilaments-a...
 
Description Neurology press release on Huang et al - media reporting 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Huang et al publication in Neurology 2020 was selected for an accompanying press release. The paper reported work on the relationship of sleeping patterns with an increased risk of dementia in people with a higher genetic risk of the condition. This led to international media interest e.g. reported by various outlets including Alzheimers Research UK and Evening Standard.
Year(s) Of Engagement Activity 2020
URL https://www.alzheimersresearchuk.org/morning-people-linked-higher-alzheimers-risk/
 
Description Oral presentation to national UKDRI Connectome Conference 2020 - Dr Rui Pinto - team member 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation on "The role of ceramide metabolism in cognitive decline and Alzheimer's disease: A metabolome-wide association analysis on ABCA7", major focus of our team research. Received comments and critiques of the work which will help with further data analysis and research direction. Reslt of collaboration with Airwave, Rotterdam and FINGER Trial research groups.
Year(s) Of Engagement Activity 2020
 
Description Presentation to 15th Annual Conference of The Metabolomics Society, June 23-27 2019, The Hague, NL 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presented methods and results of work on a new cross-cohort matching in untargeted metabolomics to generate accurate within-dataset feature matching across multiple cohorts. The new approach addresses a key problem in metabolomics studies and promises to make analysis of large untargeted multi-cohort data sets a viable option.
Year(s) Of Engagement Activity 2019
URL http://metabolomics2019.org/images/2019-Metabolomics_Abstract_9.pdf
 
Description Seminar - Does innate immunity contribute to Alzheimer's disease? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Professor Michael T Heneka Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn Gave a talk titled 'Does innate immunity contribute to Alzheimer's disease?' 13.30 - 14.30 Thursday 4 October 2018 Seminar Room 1, Wolfson Education Centre, Hammersmith Campus
Accumulation of neurotoxic amyloid-ß peptides along with neurofibrillary tangle formation represent key pathological hallmarks in Alzheimer's disease (AD). Despite the brain being viewed as an immune privileged organ, increasing evidence from translational, genetic and pathological studies suggests that activation of distinct innate immune pathways represents a third important component, which, once initiated, actively contributes to disease progression and chronicity. Microglia play a pivotal role in this immune response and are activated by binding of aggregated proteins or aberrant nucleic acids to pattern recognition receptors. This immune activation leads to the release of inflammatory mediators but also distracts microglia cells from their physiological functions and tasks. NLRP3 inflammasome activation and release of ASC specks contribute to spreading of pathology and impairs microglia clearance mechanisms together contributing to neuronal degeneration and spatial memory deficits. In keeping with this, inhibition of this immune pathways shows protection in cellular and murine models of AD. Modulation of the microglia driven innate immune response at key signalling steps may therefore provide protection and may alter progression of disease. Therefore, anti-inflammatory treatment strategies should be considered. Data on microglial activation in AD along with suggestions to modify and alter the pro- into an anti-inflammatory phenotype will be reviewed and discussed.
Year(s) Of Engagement Activity 2018
URL https://www.imperial.ac.uk/dementia-research-institute/seminars--events/past-events/
 
Description Seminar - Signalling pathways to degeneration 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Professor Giles Hardingham Associate Director, UK Dementia Research Institute at The University of Edinburgh gave a presentation titled Signalling pathways to degeneration and
resilience in the CNS at 12.30 - 13.30 Wednesday 14 November 2018 Seminar Rooms 4/5, Wolfson Education Centre,Hammersmith Campus.
Professor Hardingham's research group focuses on signalling events within and between neurons and glia, and how these interactions shape brain development and homeostasis as well as drive pathological cascades.
Year(s) Of Engagement Activity 2018
URL https://www.imperial.ac.uk/media/imperial-college/research-centres-and-groups/uk-dri/Seminar-poster-...
 
Description UK DRI 'Big Data & Dementia Research' Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Brainstorming and networking event with participants from many fields with aim of fostering cross-disciplinary collaboration
Year(s) Of Engagement Activity 2020
 
Description UK DRI Connectome Annual Conference (Virtual) 2020 - post-doc presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation on behalf of the Elliott Imperial DRI research group on ceramide metabolism and role in onset AD - raised interesting discussion with fellow delegates
Year(s) Of Engagement Activity 2020
 
Description UK Dementia Research Institute at Imperial College London Special Seminars 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Dr Katie Lunnon Associate Professor in Epigenetics, University of Exeter Medical School Gave a presentation Titled Epigenetics Mechanisms in Alzheimer's Disease from 12.30 - 13.30
Wednesday 30 January 2019 at Seminar room 10B, sub-basement, Commonwealth Building Hammersmith Campus
Year(s) Of Engagement Activity 2018
URL https://www.imperial.ac.uk/dementia-research-institute/seminars--events/past-events/