Cognition and Behaviour

Lead Research Organisation: Imperial College London

Abstract

Using radical new approaches to assess the effects of dementia and improve the lives of people living with the condition. They are creating smart sensors that can collect data about a person’s behavioural patterns in the home and using artificial intelligence to make predictions about what that person might do. They will use this information to develop ways to support them as their dementia progresses – for instance, through the use of intelligent cues that can help prompt them to do things.

The researchers have also previously developed software – called CogniTrack – that enables regular computerised home-based testing of a person’s cognitive abilities e.g. thinking, learning, memory and understanding. They will investigate whether this can provide a more sensitive measurement of a person’s brain function over the long-term, compared with standard face-to-face assessments. Combining CogniTrack data with a individual’s behavioural information will enable them to study the relationship between real-life behaviours and cognitive function in unprecedented detail.

The team will also explore exciting opportunities to improve the cognitive abilities of people with dementia – such as their memory function. They will use mobile electroencephalography (EEG) sensors to detect unusual electrical brain activity and then investigate ways to correct this, such as through the use of intelligent cues or non-invasive electrical brain stimulation.

Technical Summary

The UK Dementia Research Institute (UK DRI) is an initiative funded by the Medical Research Council, Alzheimer's Society and Alzheimer's Research UK. Funding details for UK DRI programmes will be added from 2020.

The programme will develop ways to describe behavioural patterns in the home, providing a radical new approach to the assessment of the effects of dementia. A rich 3D description of real-world tasks can be produced using wearable sensors that can measure movement and quantify how behaviour changes during disease. The team will use these to describe how activities of daily living (ADLs) change in dementia at different stages, initially using whole-body sensor suits. These data will enable the identification of the smallest subset of wearable sensors that can derive accurate behavioural descriptions. Ultimately, this will enable artificial intelligence (AI) to be trained to produce similar descriptions from passively acquired data.
Mobile EEG will provide opportunities to improve cognitive function. The research will explore whether closed-loop neuromodulation, either using environmental cueing or brain stimulation can improve cognitive function. Using this home EEG system and machine learning approaches to personalised analysis, they will investigate whether perceptual alerts targeted to EEG fluctuations can improve memory function by increasing attentional engagement.
Main objectives and research goals:
1. To develop direct measures of real-world behavioural impairment.
2. To develop artificial intelligence that learns patterns of behaviour and provides support through intelligent cueing.
3. To validate CogniTrack as a platform for the longitudinal tracking of cognitive function in dementia. To enhance cognitive function through real-time monitoring of brain activity (EEG) linked to neuromodulation produced by perceptual cueing and non-invasive brain stimulation.

Publications

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Tenovuo O (2021) Assessing the Severity of Traumatic Brain Injury-Time for a Change? in Journal of clinical medicine

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Zetterberg H (2019) Head trauma in sports - clinical characteristics, epidemiology and biomarkers. in Journal of internal medicine

 
Description  4th Frontiers in Traumatic Brain Injury Conference, 2020 (Organising Committee and Chair)
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact Improved educational and skill level of workforce
URL http://frontiersintbi.org/
 
Description COVID testing in nursing homes
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
Impact We conducted COVID testing in four West London Nursing Homes at the peak of the pandemic in April 2020. Rates of infection were high and death rates were 25%. The work was used to inform the public health response to the evolving pandemic and contributed to the government recommendations for increased COVID testing in UK Nursing homes that was issued in May 2020. The work has been published in a series of publications, starting with Graham et al, J Infection, 2020.
 
Description Main Organiser of Brain: The Conference
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact Improved educational and skill level of workforce
URL https://thebrainconference.co.uk/
 
Description National TBI/PTSD Summit, 2019, London, UK.
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Improved educational and skill level of workforce
 
Description Organised 3rd Annual Frontiers in Traumatic Brain injury meeting
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact Improved educational and skill level of workforce
URL http://frontiersintbi.org/
 
Description Rugby Football Union (RFU) Independent Expert Concussion Panel
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact Improved educational and skill level of workforce
 
Description Session Chair, Association of British Neurology Autumn meeting, 2019. London, UK.
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact Improved educational and skill level of workforce
URL https://www.theabn.org/events/EventDetails.aspx?id=1251947
 
Description TBI Session Chair, World Congress of Neurology, Dubai, October 2019.
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact Improved educational and skill level of workforce
URL https://wfneurology.org/world-congress-of-neurology-2019
 
Description 3 Artificial Intelligence for Healthcare PhD studentships
Amount £150,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 10/2019 
End 09/2023
 
Description Arrested development after paediatric traumatic brain injury: a longitudinal study of neuroimaging and clinical outcomes
Amount £200,000 (GBP)
Organisation Action Medical Research 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2020 
End 03/2022
 
Description NIHR Brain Injury MedTech Co-operative Seedcorn funding
Amount £10,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 06/2019 
End 06/2022
 
Description St Mary's Development Trust Clinical Research Fellowship
Amount £50,000 (GBP)
Organisation St. Mary's Development Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2020 
End 08/2021
 
Description Investigation of blood biomarkers of injury after traumatic brain injury. 
Organisation University of Gothenburg
Country Sweden 
Sector Academic/University 
PI Contribution Investigation of clinical and radiological effects of traumatic brain injury.
Collaborator Contribution Analysis of blood samples to identify blood biomarkers of injury.
Impact None yet
Start Year 2014
 
Description Network Dysfunction following Paediatric Traumatic Brain Injury 
Organisation University College London
Department Institute of Child Health
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuroimaging investigation of the causes of cognitive impairment after traumatic brain injury in children.
Collaborator Contribution Neuropsychological assessment of cognitive impairment and recruitment of research participants.
Impact Nothing yet.
Start Year 2014
 
Description Paediatric research network 
Organisation Addenbrooke's Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution We have set up a paediatric research network to facilitate patient recruitment into paediatric TBI studies.
Collaborator Contribution They are partners in the research project and assist with recruitment of patients.
Impact On the 23rd of February 2018, we hosted our first paediatric TBI clinical research network meeting. This was very well attended by more than 25 professionals from 10 different hospitals, neurorehabilitation centres and charities. Action Medical Research also attended. We provided an update on recruitment so far and presented some of our preliminary data.
Start Year 2017
 
Description Paediatric research network 
Organisation Child Brain Injury Trust
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution We have set up a paediatric research network to facilitate patient recruitment into paediatric TBI studies.
Collaborator Contribution They are partners in the research project and assist with recruitment of patients.
Impact On the 23rd of February 2018, we hosted our first paediatric TBI clinical research network meeting. This was very well attended by more than 25 professionals from 10 different hospitals, neurorehabilitation centres and charities. Action Medical Research also attended. We provided an update on recruitment so far and presented some of our preliminary data.
Start Year 2017
 
Description Paediatric research network 
Organisation Kings BRC
Country United Kingdom 
Sector Academic/University 
PI Contribution We have set up a paediatric research network to facilitate patient recruitment into paediatric TBI studies.
Collaborator Contribution They are partners in the research project and assist with recruitment of patients.
Impact On the 23rd of February 2018, we hosted our first paediatric TBI clinical research network meeting. This was very well attended by more than 25 professionals from 10 different hospitals, neurorehabilitation centres and charities. Action Medical Research also attended. We provided an update on recruitment so far and presented some of our preliminary data.
Start Year 2017
 
Description Paediatric research network 
Organisation St Georges Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution We have set up a paediatric research network to facilitate patient recruitment into paediatric TBI studies.
Collaborator Contribution They are partners in the research project and assist with recruitment of patients.
Impact On the 23rd of February 2018, we hosted our first paediatric TBI clinical research network meeting. This was very well attended by more than 25 professionals from 10 different hospitals, neurorehabilitation centres and charities. Action Medical Research also attended. We provided an update on recruitment so far and presented some of our preliminary data.
Start Year 2017
 
Description Saracen's rugby study 
Organisation University College London
Department Institute of Neurology
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuroimaging of potential brain injuries following Rugby related head injuries
Collaborator Contribution Clinical and blood biomarker testing of rugby related brain injuries
Impact Nothing yet.
Start Year 2016
 
Description Tau after traumatic brain injury 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution We are conducting a study of tau pathology after traumatic brain injury. We have partnered with the University of Glasgow who will be providing access to their patient cohorts, as well as expertise in TBI research.
Collaborator Contribution Access to patient cohorts, neuropsychological and neuropathological expertise.
Impact None yet
Start Year 2014
 
Description Alzheimers Research UK Annual Lecture, 2020, London, UK. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Lecture
Year(s) Of Engagement Activity 2020
 
Description British Heart Foundation Symposium, UK. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Lecture
Year(s) Of Engagement Activity 2020
 
Description Frontiers in Traumatic Brain Injury, September 2019, London, UK. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lecture
Year(s) Of Engagement Activity 2019
 
Description Keynote Lecture at 2nd Nordic Neurotrauma Conference, Lund, Sweden. 'Recent Advances and Future Trends in TBI diagnostics'. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Lecture
Year(s) Of Engagement Activity 2019
 
Description Keynote Lecture at Connectome 2019, Birmingham, UK. 'UK DRI Care Research & Technology Centre'. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Lecture
Year(s) Of Engagement Activity 2019
 
Description Keynote Lecture, Dementia 2020, London, UK. 'UK DRI Care Research & Technology Centre'. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Lecture
Year(s) Of Engagement Activity 2020
 
Description Keynote lecture at Connectome, October 2019, Birmingham, UK. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Lecture
Year(s) Of Engagement Activity 2019
 
Description Lecture at 1st UK Dementia Care Research Summit, Leeds, UK (organising committee) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Lecture
Year(s) Of Engagement Activity 2020
 
Description Lecture at 1st UK Dementia Care Research Summit, Leeds, UK (organising committee) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Lecture
Year(s) Of Engagement Activity 2020
 
Description Lecture at 2nd Nordic Neurotrauma Conference, Lund, Sweden. 'Future Perspectives: The role of molecular imaging in traumatic brain injury'. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lecture
Year(s) Of Engagement Activity 2019
 
Description Lecture at Alzheimers Society Annual Meeting. London, May 2019. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Lecture
Year(s) Of Engagement Activity 2019
 
Description Lecture at Imperial Neurotechnology Workshop. May 2019. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Lecture
Year(s) Of Engagement Activity 2019
 
Description Lecture at Neurosciences in Intensive Care International Symposium. Paris, June 2019. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lecture
Year(s) Of Engagement Activity 2019
 
Description Lecture at Royal Free Clinical Neurosciences Alumni Day, London, 2020. 'Post-traumatic Neurodegeneration & Dementia'. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Lecture
Year(s) Of Engagement Activity 2019
URL https://wfneurology.org/world-congress-of-neurology-2019
 
Description Lecture at World Congress of Neurology, Dubai, October 2019. 'How can we identify and manage progressive pathology after TBI?' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lecture
Year(s) Of Engagement Activity 2019
URL https://wfneurology.org/world-congress-of-neurology-2019
 
Description Teaching Lecture at World Congress of Neurology, Dubai, October 2019. 'Frontal cognitive dysfunction after traumatic brain injury.' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lecture
Year(s) Of Engagement Activity 2019
 
Description Alzheimers Research UK Annual Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Lecture
Year(s) Of Engagement Activity 2020
 
Description Alzheimers Research UK Annual Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Lecture
Year(s) Of Engagement Activity 2020
 
Description Association of British Neurology. October 2020, UK. 'Remote monitoring in neurology'. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Lecture
Year(s) Of Engagement Activity 2020
 
Description Human Brain Mapping 2020 Symposium lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lecture
Year(s) Of Engagement Activity 2020
 
Description Joint ECDC & WHO Europe meeting on sero-epidemiological studies, November, 2020 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lecture
Year(s) Of Engagement Activity 2020
 
Description Keynote Lecture at Connectome 2019, Birmingham, UK. 'UK DRI Care Research & Technology Centre'. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Lecture
Year(s) Of Engagement Activity 2019
 
Description Keynote Lecture, Dementia 2020, London, UK. 'UK DRI Care Research & Technology Centre'. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Lecture
Year(s) Of Engagement Activity 2020
 
Description Keynote lecture at Connectome, October 2019, Birmingham, UK. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Lecture
Year(s) Of Engagement Activity 2019
 
Description Lecture at Alzheimers Society Annual Meeting. London, May 2019. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Lecture
Year(s) Of Engagement Activity 2019
 
Description Royal Society of Medicine, 2020 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lecture
Year(s) Of Engagement Activity 2020