Mechanisms of CD4+ regulatory T (Treg) cell stability in health and disease
Lead Research Organisation:
Babraham Institute
Department Name: Immunology
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
| Rahul Roychoudhuri (Primary Supervisor) |
Publications
Afzali B
(2017)
BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.
in Nature immunology
Alvisi G
(2020)
IRF4 instructs effector Treg differentiation and immune suppression in human cancer
in Journal of Clinical Investigation
Clever D
(2016)
Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.
in Cell
Eil R
(2016)
Ionic immune suppression within the tumour microenvironment limits T cell effector function.
in Nature
Gallimore A
(2019)
Regulatory T cells in cancer: where are we now?
in Immunology
Gautam S
(2019)
The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity.
in Nature immunology
Grant FM
(2020)
BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression.
in The Journal of experimental medicine
Henning AN
(2018)
Epigenetic control of CD8+ T cell differentiation.
in Nature reviews. Immunology
Igarashi K
(2017)
BACH transcription factors in innate and adaptive immunity.
in Nature reviews. Immunology
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/N503642/1 | 30/09/2015 | 29/09/2019 | |||
| 1642652 | Studentship | BB/N503642/1 | 30/09/2015 | 29/09/2019 |
| Description | Transcriptional and epigenetic programmes of lung inflammation |
| Organisation | GlaxoSmithKline (GSK) |
| Country | Global |
| Sector | Private |
| PI Contribution | A key commercial collaboration between Rahul Roychoudhuri (RR) and GlaxoSmithKline (GSK)/Epinova, which is now supported by two BBSRC CASE awards, aims to understand the transcriptional and epigenetic programmes that promote lung inflammation. We aim to define transcriptional and epigenetic mechanisms by which airway immune homeostasis is maintained by transcriptional and epigenetic regulators. |
| Collaborator Contribution | Support of CASE awards, co-supervision of PhD students, supply of pharmacological agents for use as tool compounds in assessment of epigenetic regulators |
| Impact | We have gained an understanding of how lung inflammation is restrained by suppression of ILC2 activation and promotion of Treg differentiation by the transcription factor BACH2 and are exploring mechanisms by which BACH2 may regulate epigenetic programmes in T cells |
| Start Year | 2016 |
| Description | Babraham Institute Schools Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | A group of six 6th form students were hosted at the laboratory and performed an experiment to resolve the cellular composition of secondary lymphoid tissues using flow cytometry. Students dissected mouse tissues, processed tissues into single cell suspensions, and used fluorescent labelling to distinguish a variety of immune cell populations |
| Year(s) Of Engagement Activity | 2017 |
| Description | School visit to the Roychoudhuri laboratory for hands-on experience in flow cytometry and cellular immunology |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Two groups of six school children were hosted in the laboratory and were provided hands-on experience processing tissues and using flow cytometry to distinguish populations of lymphoid cells in secondary lymphoid organs using multiparameter flow cytometry. Students were also taught basic scientific background relating to the adaptive immune system |
| Year(s) Of Engagement Activity | 2019 |
| Description | School visit to the Roychoudhuri laboratory for hands-on experience in flow cytometry and cellular immunology |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Two groups of six school children were hosted in the laboratory and were provided hands-on experience processing tissues and using flow cytometry to distinguish populations of lymphoid cells in secondary lymphoid organs using multiparameter flow cytometry. Students were also taught basic scientific background relating to the adaptive immune system |
| Year(s) Of Engagement Activity | 2017 |