Modification to decellularized Extracellular Matrix tissues to improve their vascular performance as a tissue engineered scaffold

Lead Research Organisation: University of Edinburgh
Department Name: Sch of Engineering

Abstract

My study will focus on how tissue can be decellularized in a manner which helps the attachment of new cells. The demand for full organ transplants is rising, increasing the need in technological developments in biomedical engineering. An appropriate method to decellularizing tissue (small intestine submucosa) will be found with a focus on modifying the structure to aide cell attachment. New cells will then be added to the scaffold with the aim to get good all round attachment and subsequent growth. Achieving this will be a step towards growing organs tailored to each patient and reducing the burden on transplanted organs

Publications

10 25 50
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Reid J (2019) Influence of aorta extracellular matrix in electrospun polycaprolactone scaffolds in Journal of Applied Polymer Science

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Reid JA (2020) Hybrid cardiovascular sourced extracellular matrix scaffolds as possible platforms for vascular tissue engineering. in Journal of biomedical materials research. Part B, Applied biomaterials

Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/N509644/1 01/10/2016 30/09/2021
1783121 Studentship EP/N509644/1 01/09/2016 29/02/2020 James Alexander Reid
 
Description British Heart Foundation Travel Award
Amount £150 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2018 
End 09/2018
 
Description TCES travel bursary
Amount £150 (GBP)
Organisation Tissue and Cell Engineering Society 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2018 
End 07/2018
 
Description Travel Grant
Amount £300 (GBP)
Organisation Institute of Physics and Engineering in Medicine (IPEM) 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2019 
End 09/2019
 
Description Travel Grant
Amount € 3,680 (EUR)
Organisation Boehringer Ingelheim 
Sector Private
Country Germany
Start 02/2020 
End 05/2020