Deciphering glycan fingerprint of healthy microbiota

Lead Research Organisation: University of East Anglia
Department Name: Graduate Office

Abstract

Human mucosal surfaces such as gastrointestinal tract harbour numerous numbers of microbes, so called microbiota. Advances in microbiology suggest that microbiota have significant influence on human physiology (e.g. preserving healthy gut functions). In this project, the successful candidate will aim to address the key question in the field "what the healthy microbiota looks like?". The research outputs will provide us better understanding on the microbial community in the gut and pave the way to improve gut health by modulating microbiota.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/M011216/1 01/10/2015 30/09/2023
1786460 Studentship BB/M011216/1 01/10/2016 30/09/2020 Dimitra Lamprinaki
 
Description Discovered binding of a certain bacteria species (disease-associated) to a lectin expressed by myeloid cells. This binding maybe involves in the disease progression and currently we investigate this.
Exploitation Route A potential drug development based on blocking the certain lectin and bacteria interactions.
Sectors Pharmaceuticals and Medical Biotechnology

 
Description Engagement with the public in Norwich 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact In this public engagement activity, in the main square of Norwich general public stopped by to hear about gut microbiota and they completed some quizzes to test their knowledge in the topic. People were interested in the topic and seemed to learn a lot of facts that they weren't aware of before.
Year(s) Of Engagement Activity 2018
URL http://soapboxscience.org/soapbox-science-2018-norwich
 
Description Engagement with the university of Italy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Visit in the university of Italy, Parma and knowledge exchange through oral presentations from both students studied in Italy and students from Quadram Institute Bioscience in Norwich.
Year(s) Of Engagement Activity 2018