Validation of clinical radionuclide therapy dose distribution by a novel system of 3d printed organs

Lead Research Organisation: University of Manchester
Department Name: Physics and Astronomy

Abstract

The aim of the project is to show accurate in vivo dosimetry for clinical molecular radiotherapy using single photon emmission computed tomography. This will be done using Monte Carlo simulations and 3D printed patient organs. CT scans of the 3D printed organs, acquired on a hybrid SPECT/CT system, will be used as input for the Monte Carlo simulations allowing the use of voxelised phantom models.

Publications

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Price E (2019) Improving molecular radiotherapy dosimetry using anthropomorphic calibration. in Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

 
Description Changed current practice for calibration Single Photon Emission Computed Tomography (SPECT) imaging.
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Influenced methods of personalised dosimetry for single photon emission computed tomography (spect).
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Positional dependence of activity determination in SPECT - submitted article to Nuclear Medicine Communications to demonstrate the importance of verifying attenuation correction in clinical software.
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description STFC Industrial CASE Studentship Panel (Dave Cullen)
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
URL https://stfc.ukri.org/funding/studentships/industrial-case-studentships/
 
Description STFC Industrial Case Award - Validation of clinical radionuclide therapy dose distribution by a novel system of 3D printed anthropomorphic phantoms.
Amount £80,000 (GBP)
Funding ID ST/M003302/1 
Organisation Science and Technologies Facilities Council (STFC) 
Sector Public
Country United Kingdom
Start 09/2015 
End 10/2019
 
Title A custom made elliptical phantom (CATIE, the Christie Anatomical Tomographic Imaging Ellipse) 
Description A custom made elliptical phantom (CATIE, the Christie Anatomical Tomographic Imaging Ellipse) has been employed to scan a range of patient organ phantoms to investigate geometrical effects. 
Type Of Material Improvements to research infrastructure 
Year Produced 2013 
Provided To Others? Yes  
Impact The phantom was used at The Christie to allow new data to be collected. These data were analysed and resulted in 3 publications so far. 
 
Title Anthropomorphic Dose Calculation Code 
Description A bespoke code was developed to calculate dose for a range of medical isotopes using the DICOM data input. Registration of the regions of interest were used to tag each voxel on the binary image, subsequently used in parallel with the Dose Actor class provided in OpenGATE. This enabled the individual voxelised dose to each organ to be summed respectively, then related to the residency time for the specific radioisotope. Particle filter types were utilised to enable separation of different decay modes impact to dose, namely beta and gamma absorption. 
Type Of Material Data analysis technique 
Year Produced 2017 
Provided To Others? No  
Impact These results were published in Physica Medica. 
 
Description Hermes Medical Solutions Limited 
Organisation Hermes Medical Solutions
Country Sweden 
Sector Private 
PI Contribution Non-DIsclosure agreement in place. We have shared informaiton on Monte-Carlo modelling and dosimerty.
Collaborator Contribution Hemes has shared information and have modified their commercial code to support our work. They have given us unique access to their code developers.
Impact Additional grant proposal currently in submission through the STFC CLASP Scheme
Start Year 2010
 
Description NPL 
Organisation National Physical Laboratory
Country United Kingdom 
Sector Academic/University 
PI Contribution We have shared information on SOECT cameras calibration and nuclear physics knowledge.
Collaborator Contribution NPL has provided access to absolute calibration standards
Impact A new PhD student has been sponsored through this collaboration
Start Year 2016
 
Description The Christie NHS Foundation Trust, Nuclear Medicine Department. 
Organisation The Christie NHS Foundation Trust
Department Christie Medical Physics and Engineering
Country United Kingdom 
Sector Hospitals 
PI Contribution We have provided the physics expertise needed to deliver improved dose calculations for Molecular Radiotherapy treatments at The Christie. This work has combined existing expertise in Monte-Carlo simulation, from basic nuclear physics research, and novel new 3D printing techniques. This collaboration has already delivered improved activity quantification for MRT at The Christie which provide the foundation of accurate and optimised patient dose calculations.
Collaborator Contribution The Christie has provide access to anonymised patient data, clinical SPECT cameras, Molecular Radio Therapy (MRT) isotopes and current MRT dosimetry software which has allowed the techniques developed in this work to be translate to a clinical environment. The research output from this collaboration has provided improved activity quantification and validation of exiting MRT dosimetry software.
Impact This collaboration has delivered improved activity quantification for Molecular Radio Therapy at The Christie which provide the foundation of accurate and optimised patient dose calculations. The research output from this collaboration has provided improved activity quantification and validation of exiting Molecular Radio Therapy dosimetry software. The collaboration has submitted two research papers on this work.
Start Year 2009
 
Description NPL MEMPHYS Workshop on Applications of 3D printing for medical phantoms 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk title: An individual approach to Molecular radiotherapy
dosimetry using 3D printed phantoms
Year(s) Of Engagement Activity 2017
 
Description Talk at IOP Nuclear Physics Conference, 3-6 April, University of Birmingham, Birmingham, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Presented talk at the IOP Nuclear Physics Conference, 3-6 April, University of Birmingham, Birmingham, UK.Talk entitles: Patient specific Monte Carlo dose calculations for 3D printed phantom studies
Year(s) Of Engagement Activity 2017
 
Description Talk at Radiotherapy Modelling Workshop at Luz Saint Sauveur 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presented a talk at a workshop on radiotherapy modelling organised by the SFPM (Société Française de Physique Médicale). Dates: 21 - 24 September 2016. Talk title: 'Patient specific Monte Carlo dose calculations for 3D printed phantom studies in molecular radiotherapy'
Year(s) Of Engagement Activity 2016
URL http://luz2016.sfpm.fr/Luz/Welcome.html
 
Description Workshop: Headstart Summer school 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Talk title: An introduction to Nuclear medicine. Presentation to teachers at the "teach the teachers" meeting.
Year(s) Of Engagement Activity 2017