Validation of clinical radionuclide therapy dose distribution by a novel system of 3d printed organs
Lead Research Organisation:
University of Manchester
Department Name: Physics and Astronomy
Abstract
The aim of the project is to show accurate in vivo dosimetry for clinical molecular radiotherapy using single photon emmission computed tomography. This will be done using Monte Carlo simulations and 3D printed patient organs. CT scans of the 3D printed organs, acquired on a hybrid SPECT/CT system, will be used as input for the Monte Carlo simulations allowing the use of voxelised phantom models.
People |
ORCID iD |
| David Matthew Cullen (Primary Supervisor) | |
| Emlyn Price (Student) |
| Description | Changed current practice for calibration Single Photon Emission Computed Tomography (SPECT) imaging. |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Influenced methods of personalised dosimetry for single photon emission computed tomography (spect). |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Positional dependence of activity determination in SPECT - submitted article to Nuclear Medicine Communications to demonstrate the importance of verifying attenuation correction in clinical software. |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | STFC Industrial CASE Studentship Panel (Dave Cullen) |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| URL | https://stfc.ukri.org/funding/studentships/industrial-case-studentships/ |
| Description | STFC Industrial Case Award - Validation of clinical radionuclide therapy dose distribution by a novel system of 3D printed anthropomorphic phantoms. |
| Amount | £80,000 (GBP) |
| Funding ID | ST/M003302/1 |
| Organisation | Science and Technologies Facilities Council (STFC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2015 |
| End | 10/2019 |
| Title | A custom made elliptical phantom (CATIE, the Christie Anatomical Tomographic Imaging Ellipse) |
| Description | A custom made elliptical phantom (CATIE, the Christie Anatomical Tomographic Imaging Ellipse) has been employed to scan a range of patient organ phantoms to investigate geometrical effects. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2013 |
| Provided To Others? | Yes |
| Impact | The phantom was used at The Christie to allow new data to be collected. These data were analysed and resulted in 3 publications so far. |
| Title | Anthropomorphic Dose Calculation Code |
| Description | A bespoke code was developed to calculate dose for a range of medical isotopes using the DICOM data input. Registration of the regions of interest were used to tag each voxel on the binary image, subsequently used in parallel with the Dose Actor class provided in OpenGATE. This enabled the individual voxelised dose to each organ to be summed respectively, then related to the residency time for the specific radioisotope. Particle filter types were utilised to enable separation of different decay modes impact to dose, namely beta and gamma absorption. |
| Type Of Material | Data analysis technique |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | These results were published in Physica Medica. |
| Description | Hermes Medical Solutions Limited |
| Organisation | Hermes Medical Solutions |
| Country | Sweden |
| Sector | Private |
| PI Contribution | Non-DIsclosure agreement in place. We have shared informaiton on Monte-Carlo modelling and dosimerty. |
| Collaborator Contribution | Hemes has shared information and have modified their commercial code to support our work. They have given us unique access to their code developers. |
| Impact | Additional grant proposal currently in submission through the STFC CLASP Scheme |
| Start Year | 2010 |
| Description | NPL |
| Organisation | National Physical Laboratory |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have shared information on SOECT cameras calibration and nuclear physics knowledge. |
| Collaborator Contribution | NPL has provided access to absolute calibration standards |
| Impact | A new PhD student has been sponsored through this collaboration |
| Start Year | 2016 |
| Description | The Christie NHS Foundation Trust, Nuclear Medicine Department. |
| Organisation | The Christie NHS Foundation Trust |
| Department | Christie Medical Physics and Engineering |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | We have provided the physics expertise needed to deliver improved dose calculations for Molecular Radiotherapy treatments at The Christie. This work has combined existing expertise in Monte-Carlo simulation, from basic nuclear physics research, and novel new 3D printing techniques. This collaboration has already delivered improved activity quantification for MRT at The Christie which provide the foundation of accurate and optimised patient dose calculations. |
| Collaborator Contribution | The Christie has provide access to anonymised patient data, clinical SPECT cameras, Molecular Radio Therapy (MRT) isotopes and current MRT dosimetry software which has allowed the techniques developed in this work to be translate to a clinical environment. The research output from this collaboration has provided improved activity quantification and validation of exiting MRT dosimetry software. |
| Impact | This collaboration has delivered improved activity quantification for Molecular Radio Therapy at The Christie which provide the foundation of accurate and optimised patient dose calculations. The research output from this collaboration has provided improved activity quantification and validation of exiting Molecular Radio Therapy dosimetry software. The collaboration has submitted two research papers on this work. |
| Start Year | 2009 |
| Description | NPL MEMPHYS Workshop on Applications of 3D printing for medical phantoms |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk title: An individual approach to Molecular radiotherapy dosimetry using 3D printed phantoms |
| Year(s) Of Engagement Activity | 2017 |
| Description | Talk at IOP Nuclear Physics Conference, 3-6 April, University of Birmingham, Birmingham, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Presented talk at the IOP Nuclear Physics Conference, 3-6 April, University of Birmingham, Birmingham, UK.Talk entitles: Patient specific Monte Carlo dose calculations for 3D printed phantom studies |
| Year(s) Of Engagement Activity | 2017 |
| Description | Talk at Radiotherapy Modelling Workshop at Luz Saint Sauveur |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented a talk at a workshop on radiotherapy modelling organised by the SFPM (Société Française de Physique Médicale). Dates: 21 - 24 September 2016. Talk title: 'Patient specific Monte Carlo dose calculations for 3D printed phantom studies in molecular radiotherapy' |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://luz2016.sfpm.fr/Luz/Welcome.html |
| Description | Workshop: Headstart Summer school |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Talk title: An introduction to Nuclear medicine. Presentation to teachers at the "teach the teachers" meeting. |
| Year(s) Of Engagement Activity | 2017 |