Synthesis of Stemona Alkaloids by Pd(II)-Catalysed C-H Activated Cascade Sequences

Lead Research Organisation: University of Bristol
Department Name: Chemistry

Abstract

This project is concerned with the development of new strategies towards the 7-membered polycyclic Stemona alkaloid family, many of which possess interesting biological activities e.g. cough suppressant and insecticidal. The work will initially concentrate on the formation of the perhydroazazulene (7,5) ring system by investigating Pd(II)-catalysed C-H activation-cyclisation reactions of pyrroles. This work will then be expanded to investigate similar cascade cyclisations to make tri- and tetracyclic systems. Once the methodology is proven we use it in a total synthesis of bisdehydro-tubostemonamidine.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/N509619/1 01/10/2016 30/09/2021
1793177 Studentship EP/N509619/1 01/10/2016 31/05/2020 Daniel Giernalczyk