A "top down" approach to diverse small molecule scaffolds

Lead Research Organisation: University of Leeds
Department Name: Sch of Chemistry


Historically, chemists' exploration of chemical space has been uneven and unsystematic. Most diversity-oriented approaches to expand the range of available molecular scaffolds have exploited a the "build-couple-pair" approach in which building blocks are linked and then cyclised to yield scaffolds. This iCASE project (with AstraZeneca) will develop a complementary "top down" approach in which complex, yet synthetically accessible, intermediates are simplified/developed to yield alternative molecular scaffolds. The biological relevance of the novel scaffolds will be investigated.


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Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/P510555/1 01/10/2016 30/09/2021
1799563 Studentship EP/P510555/1 01/10/2016 31/03/2020 Chloe Elizabeth Townley
Description AstraZeneca Collaboration 
Organisation AstraZeneca
Department Oncology
Country United Kingdom 
Sector Private 
PI Contribution Experimental research into the top down approach to Lead-Oriented Synthesis (LOS). I undertook a 2 month placement at AZ's Darwin site in Cambridge, during which time I undertook my own research and attended discussion groups and project meetings.
Collaborator Contribution During my placement my industrial supervisor offered support and training on new equipment as well as troubleshooting any technical problems I was encountering, as well as an interesting insight to industrial research and the company as a whole. Aside from placement they offer input on the direction of the project as well as financial support through out my PhD.
Impact None as of yet
Start Year 2016