Revealing DNA's Secret Structures

Lead Research Organisation: University of East Anglia
Department Name: Pharmacy

Abstract

Think you know the structure of DNA? Think again. It is often assumed that DNA exists only as the iconic Watson-Crick "twisted ladder" double helix; but it can actually adopt many different types of structures. These "alternative" structures may play a role in gene expression (whether genes are switched on or off) and also in the development and progression of genetic diseases. Compared to the double helix, much less is known about these structures, how and when they may form in the genome. Potentially, targeting these alternative DNA structures could allow for specific interventions and therapeutics for genetic diseases.

This PhD project will involve developing fluorescent probes so we can learn more about these alternative DNA structures.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/M011216/1 01/10/2015 30/09/2023
1800176 Studentship BB/M011216/1 01/10/2016 30/09/2020 Philip Spence
 
Description Have submitted a paper that shows the development of a new class of DNA probes.
Exploitation Route The class of compounds that act as DNA probes can be taken on and derivatised to find new ones.
Sectors Pharmaceuticals and Medical Biotechnology

 
Description BIONIC 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Presented a poster of my work at this international conference. Gained insight into my work and managed to share it with others.
Year(s) Of Engagement Activity 2018
URL https://www.bionic2018.org/
 
Description G4thering 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Presented a poster at an international conference. Gained lots of ideas and insight into my research and was able to share my research with others.
Year(s) Of Engagement Activity 2017
URL http://www.rsc.org/events/detail/25441/g4thering-2017
 
Description Norwich Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Engaged with the general public at the Norwich Science Festival 2017, demonstrating the research that our group undertakes.
Year(s) Of Engagement Activity 2017
URL https://norwichsciencefestival.co.uk/