DNA gyrase in plants and plasmodial parasites

Lead Research Organisation: University of East Anglia
Department Name: Graduate Office

Abstract

DNA topoisomerase VI is an enzyme that was originally discovered in archaea but has more recently been found in plants (Arabidopsis thaliana) and malaria parasites (Plasmodium falciparum). Rather little is known about this enzyme but it has key roles in plant growth and development and in the plasmodium life cycle. We will characterise this enzyme, initially from the archeon Methanosarcina mazei, and learn more about the reactions that it catalyses. We will then characterise topo VI enzymes from A. thaliana and P. falciparum and investigate their role in plants and plasmodia. We will go on to develop inhibitors of the enzyme, specifically we aim to screen libraries of compounds and investigate the mechanism of action of compounds that are found to inhibit the enzyme.

Publications

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Wallace MD (2018) Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action. in Chemical communications (Cambridge, England)

Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/M011216/1 01/10/2015 30/09/2023
1805532 Studentship BB/M011216/1 01/10/2016 30/09/2020 Nidda Waraich