Identification of novel routes to modulate GMSC function to promote repair of gingival tissue

Lead Research Organisation: King's College London
Department Name: Craniofacial Dev and Stem Cell Biology

Abstract

The aim of this work proposed here is to characterise gingival mesenchymal stem cells derived from healthy and inflamed gingival tissue. Cell 'stemness' will be confirmed by performing colony forming assays and by examining multi-differentiation potential, including the ability of the cells to differentiate into gingival tissue. Studies comparing gene and protein expression of stem cells derived from healthy and inflamed tissue will also be carried out, with the aim of identifying 'healthy' and 'inflamed' gingival stem cell markers and to identify pathways and networks involved. The responses of 'healthy' and 'diseased' GMSCs exposed to inflammatory triggers will also be examined and it will be determined if these responses can be modulated using inhibitors and/or activators of the key pathways identified.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/P504506/1 01/10/2016 30/09/2020
1820601 Studentship BB/P504506/1 01/10/2016 30/09/2020 Ana Sofia Justo Caetano
 
Description Arts in Dentistry workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact The Cultural Institute's Arts, Health and Wellbeing innovation programme explored how the arts can enhance health and wellbeing in clinical and care settings. The Arts in Dentistry strand offered opportunities for artists and arts organisations to develop new conversations and collaborations with Dental Institute researchers at King's College London. The aim was to conceive and develop experimental arts-based approaches to Understanding Disease, Enhancing Health and Restoring Function, with seed-funding being made available to the best ideas that emerge.
Year(s) Of Engagement Activity 2018