The role of CD8:B lymphocyte interactions in Type 1 Diabetes pathogenesis
Lead Research Organisation:
King's College London
Department Name: Immunology Infection and Inflam Diseases
Abstract
The aim of this study is to investigate the contribution of interactions between B cells and CD8+ T cells to Type 1 Diabetes
pathogenesis. The overall hypothesis is that cognate interactions between autoreactive B and CD8+ T cells, specifically B cell
cross presentation of islet autoantigen to CD8+ T cells, contributes to disease by promoting cytotoxic responses which mediate
the destruction of pancreatic B-cells.
pathogenesis. The overall hypothesis is that cognate interactions between autoreactive B and CD8+ T cells, specifically B cell
cross presentation of islet autoantigen to CD8+ T cells, contributes to disease by promoting cytotoxic responses which mediate
the destruction of pancreatic B-cells.
Organisations
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| MR/N013700/1 | 01/10/2016 | 30/09/2025 | |||
| 1847476 | Studentship | MR/N013700/1 | 26/09/2016 | 31/01/2021 | Emily Hanton |