EFFICIENT HIGH HARMONIC GENERATION SOURCES FOR APPLICATIONS IN X-RAY IMAGING

Lead Research Organisation: University of Southampton
Department Name: Optoelectronics Research Centre

Abstract

High Harmonic Generation (HHG) has moved from being an experiment in itself to acting as a light source for new experimental techniques. In the time domain this is well documented, but HHG sources for applications which make use of the spatial coherence of the HHG as well as its other properties are much less well developed. The work in this thesis aims to develop efficient and spatially coherent sources of XUV and soft X-ray radiation for use in experiments such as coherent imaging, which rely heavily on the coherence properties of the HHG. the efficiency of generation will be explored via study of wavelength dependence and phase matching, with the emphasis on concurrent high spatial coherence. The development of high-resolution X-ray microscopy of a range of samples, which requires both high flux and high coherence, will be used as a test case to refine the HHG source properties.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/N509747/1 01/10/2016 30/09/2021
1921431 Studentship EP/N509747/1 29/09/2016 30/09/2020 Charles Pooley
 
Description Established ptychography with a high harmonic source as a viable method for imaging biological samples, specifically neuron cells. Improved the resolution of images to 50nm and compared with other optical imaging techniques and super-resolution imaging methods with image correlation.
Exploitation Route The imaging method developed during this project may be useful for identifying structural defects in neural microtubules as a result of tau protein misfolding, which is a cause for many degenerative illnesses.
Sectors Pharmaceuticals and Medical Biotechnology,Other