X-ray crystallography on sub milligram samples
Lead Research Organisation:
University College London
Department Name: Chemistry
Abstract
This project will investigate the applicability of the crystalline sponge method to cover trace level structural problems encountered in crop protection R&D. The project will involve the synthesis of crystalline metal organic frameworks (MOFs) as a porous matrix into which compounds in solution can be soaked allowing the molecular structure determination of non-crystalline complexes via X-ray diffraction.
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| EP/R512138/1 | 01/10/2017 | 30/09/2022 | |||
| 1922176 | Studentship | EP/R512138/1 | 01/10/2017 | 11/09/2021 | Richard Lunn |
| Description | Three different MOFs and a few different organic linker compounds have been successfully synthesized expanding the original method to encapsulate both hydrophobic and hydrophilic compounds. A range of compounds (guests) have been successfully encapsulated within all three MOFs resulting in approximately 13 novel inclusion complexes, the intermolecular interactions between the host framework and guest were also studied. Three of the compounds encapsulated are related to agrochemical active ingredients in an attempt to expand the method into the agrochemical industry. The effect of different temperatures on the encapsulation of a few of the target guests has also been investigated. One paper has been published with some of this work with a second in review. |
| Exploitation Route | The knowledge of what types of guest compounds that can be encapsulated can be used by others to inform their decisions for future experiments. |
| Sectors | Agriculture, Food and Drink,Chemicals,Healthcare,Pharmaceuticals and Medical Biotechnology |
| URL | https://pubs.acs.org/doi/10.1021/acs.cgd.0c00901 |