Exploiting the bacterial surface for new vaccines

Lead Research Organisation: University of Birmingham
Department Name: Institute of Immunology & Immunotherapy

Abstract

Vaccines prevent between 2 and 8 million deaths each year. In this joint project, between the University of Birmingham and GSK Vaccines Institute for Global Health, the student will develop a number of new approaches to maximise the benefit and cost-effectiveness of vaccination, the longevity of the response to the vaccine and the type of response induced. Ultimately, the study will contribute to the development of affordable multi-valent vaccines that can be used in high and low income countries.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/M01116X/1 01/10/2015 30/09/2023
1940269 Studentship BB/M01116X/1 02/10/2017 30/09/2021 Sian Jossi
 
Description Key findings so far include:
* identification of antibody isotypes involved in protection and longevity of the response to polysaccharide, conjugate and OMV based Salmonella vaccines
* validating a detoxified form of OMV vaccine
Exploitation Route This research so far will further vaccine development for all 3 platforms tested, as well as potentially informing global vaccine distribution/application policy (re: identifying vaccines with optimal immune response).
Sectors Healthcare,Pharmaceuticals and Medical Biotechnology

 
Description GVGH studentship 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution Research on vaccines. Will attend an intership in future.
Collaborator Contribution Provision of additional funding, vaccines and research materials.
Impact Nearly all data generated so far has bene on vaccines generated by the collaborators. In addition, I have attended and presented at a student symposium (2019) and will attend a 3 month internship in future.
Start Year 2017
 
Description After school club visit (Hillcrest School & Sixth Form Centre) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact WISE is an organisation designed to link women in STEM fields with young girls to encourage exploration of the sciences. Approx 30 students attended an after school club science lesson on polymers, with a practical session on making 'slime' and the chemistry behind it. The students were encouraged to ask questions one-on-one with instructors and at the end were informally quizzed on the science, with responses indicating sucessful leanring and enthusiasm to learn more chemistry.
Year(s) Of Engagement Activity 2018