Stereoretentive enantioconvergent synthesis

Lead Research Organisation: University of Edinburgh
Department Name: Sch of Chemistry


This project will experimentally establish a new concept in asymmetric synthesis: stereoretentive enantioconvergent catalysis. This project will establish a conceptually new stereoretentive-dimerisation approach that results in both enantiomers of the starting material being incorporated into the product with no deracemisation required. Several approaches will be pursued to demonstrate proof-of principle, and applications in the synthesis of complex natural and unnatural products will then be used to demonstrate the potential of stereoretentive-enantioconvergent catalysis in target-orientated synthesis.


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Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/N509644/1 01/10/2016 30/09/2021
1940582 Studentship EP/N509644/1 01/09/2017 31/08/2021 Helen Jones
Description I have focused a Diels-Alder dimersation as part of my project. Specifically I have been working towards the synthesis of the monomer, and trying to make to monomer in a large quantity so I can later scope different chiral reagents and catalysts to render the original Diels-Alder dimerisation enantioconvergent.
Exploitation Route The synthesis of the monomer
Sectors Chemicals,Pharmaceuticals and Medical Biotechnology