Promoting the remineralisation of subsurface caries lesions

Lead Research Organisation: University of Edinburgh
Department Name: Sch of Chemistry


Project Aim: To develop methods to promote the remineralisation of lesions in tooth enamel.

This collaborative project with Reminova will explore electro-chemical deposition methods to induce the remineralisation of lesions in the tooth enamel, aiming for the repair of the tooth. The project will focus on electron microscopy and spectroscopic techniques (SEM, TEM, XRD, FTIR, Raman) to investigate the mechanisms of electro-chemical precipitation of hydroxyapatite on enamel and methods to improve the remineralisation and repair of the tooth. This project is a collaboration between the School of Chemistry, the School of Dentistry and Reminova.


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Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/N509644/1 01/10/2016 30/09/2021
1941120 Studentship EP/N509644/1 01/09/2017 28/02/2021 Dahlia Eldosoky
Description Utilising electrochemical methods results in the enhancement of calcium phosphate crystallisation using. Applying a potential is capable of generating thin films of amorphous calcium phosphate, at early time points, such that these were imaged using electron microscopy and diffraction data provided the information regarding the type of material produced. Electrochemical Impedance Spectroscopy was able to give more insight on how to process is faster compared to not applying an electric field. This was also tested on real tooth but the results showed that further investigation was required.
Exploitation Route The outcomes of the research will provide the fundamentals of the process of using electrochemical methods for enhancing calcium phosphate crystallisation. This could be taken forward by other prospective researchers to further validate and optimise the process, focusing on biologically relevant materials for remineralisation, such as teeth and bone.
Sectors Healthcare,Pharmaceuticals and Medical Biotechnology

Description Collaborating with the Electrochemistry Group in the School of Chemistry 
Organisation University of Edinburgh
Department School of Chemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution The contributions made by me include providing crystallisation knowledge, electron microscopy/diffraction and basic intellectual chemistry input in order to attain the project goal.
Collaborator Contribution The electrochemistry group have provided immense electrochemistry knowledge and help, especially aiding in training with instruments such as potentiostats. Their expertise included aiding in data manipulation/analysis to intellectual contributions with the overall research goal.
Impact The collaboration is multi-disciplinary as it is bringing both the electrochemistry and crystallisation fields together. Through this collaboration, we have been able to utilise various techniques such as cyclic voltammetry, chronoamperometry/chronopotentiometry, electrochemical impedance spectroscopy, electron microscopy and electron diffraction to provide a comprehensive look into the extent of enhancing calcium phosphate crystallisation via an electric field. Through this, we are on route to providing a model of how the process happens. This is a platform for utilising such process for more biologically relevant materials such as bone and teeth.
Start Year 2018